Редактирование: BAALC

Brain and acute leukemia cytoplasmic protein

==Publications==

{{medline-entry
|title=Relation of [[BAALC]] and [[ERG]] Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26625814
|abstract=The objectives of this study were to evaluate the expression of brain and acute leukemia, cytoplasmic ([[BAALC]]) gene and erythroblast transformation-specific related gene ([[ERG]]) in de novo cases of acute myeloid leukemia (AML) and identify roles in disease progression and outcome. This study included 50 newly diagnosed AML patients, along with 10 apparently healthy normal controls. [[BAALC]] and [[ERG]] expression was detected in the bone marrow of both patients and controls using real-time RT-PCR. [[BAALC]] and [[ERG]] expression was detected in 52% of cases but not in any controls. There was a statistically significant correlation between [[BAALC]] and [[ERG]] gene expression and age (p- value=0.004 and 0.019, respectively). No statistical significance was noted for sex, lymphadenopathy, hepatomegaly, splenomegaly, other hematological findings, immunophenotyping and FAB sub-classification except for [[ERG]] gene and FAB (p-value=0.058). A statistical significant correlation was found between response to treatment with [[ERG]] expression (p-value=0.028) and age (p-value=0.014). A statistically significant variation in overall survival was evident with patient age, BM blast cells, FAB subgroups, [[BAALC]] and [[ERG]] expression (p-value= <0.001, 0.045, 0.041, <0.008 and 0.025 respectively). Our results suggest that [[BAALC]] and [[ERG]] genes are specific significant molecular markers in AML disease progression, response to treatment and survival.
|mesh-terms=* Adult
* Aging
* Biomarkers, Tumor
* Bone Marrow
* Bone Marrow Cells
* Disease Progression
* Egypt
* Female
* Gene Expression Profiling
* Humans
* Leukemia, Myeloid, Acute
* Male
* Middle Aged
* Neoplasm Proteins
* Trans-Activators
* Transcriptional Regulator ERG
* Treatment Outcome

|full-text-url=https://sci-hub.do/10.7314/apjcp.2015.16.17.7875
}}