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Aging genes 30-39
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__NOTOC__ * [[Aging genes 300|Genes with 300 and more publications]] * [[Aging genes 200-299|Genes with 200-299 publications]] * [[Aging genes 100-199|Genes with 100-199 publications]] * [[Aging genes 90-99|Genes with 90-99 publications]] * [[Aging genes 80-89|Genes with 80-89 publications]] * [[Aging genes 70-79|Genes with 70-79 publications]] * [[Aging genes 60-69|Genes with 60-69 publications]] * [[Aging genes 50-59|Genes with 50-59 publications]] * [[Aging genes 40-49|Genes with 40-49 publications]] * [[Aging genes 30-39|Genes with 30-39 publications]] * [[Aging genes 20-29|Genes with 20-29 publications]] * [[Aging genes 10-19|Genes with 10-19 publications]] * [[Aging genes 5-9|Genes with 5-9 publications]] * [[Aging genes 3-4|Genes with 3-4 publications]] * [[Aging genes 1-2|Genes with 1-2 publications]] * [[Aging_genes_A-Z_table]] ==CCL2== * {{medline-title |title=Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: Sex differences and role of purinergic receptors. |date=07.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166661 |full-text-url=https://sci-hub.do/10.1016/j.bbi.2020.11.013 }} * {{medline-title |title=Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. |date=01.2021 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187870 |full-text-url=https://sci-hub.do/10.1016/j.jdiacomp.2020.107758 }} * {{medline-title |title=[[IL1B]] triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via [[CCL2]]. |date=25.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099841 |full-text-url=https://sci-hub.do/10.1111/aji.13365 }} * {{medline-title |title=Eosinophils and White Fat: Protection from Worms and Inflammaging. |date=08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32718231 |full-text-url=https://sci-hub.do/10.1089/rej.2020.2375 }} * {{medline-title |title=[[CXCL9]] and [[CXCL10]] display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil. |date=11.05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32393333 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216412 }} * {{medline-title |title=p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. |date=06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272174 |full-text-url=https://sci-hub.do/10.1016/j.antiviral.2020.104784 }} * {{medline-title |title=β1 Integrin regulates adult lung alveolar epithelial cell inflammation. |date=30.01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873073 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098727 }} * {{medline-title |title=Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. |date=01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31734849 |full-text-url=https://sci-hub.do/10.1007/s00204-019-02607-2 }} * {{medline-title |title=Klotho-mediated targeting of [[CCL2]] suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. |date=11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545552 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822285 }} * {{medline-title |title=Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. |date=07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30872008 |full-text-url=https://sci-hub.do/10.1016/j.neuint.2019.03.004 }} * {{medline-title |title=Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic [[PIK3CA]] accompanied with pro-tumorigenic secretome. |date=01.08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30671946 |full-text-url=https://sci-hub.do/10.1002/ijc.32153 }} * {{medline-title |title=Isoflurane anesthesia impairs the expression of immune neuromodulators in the hippocampus of aged mice. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30571762 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301699 }} * {{medline-title |title=Melatonin and inflammation-Story of a double-edged blade. |date=11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30242884 |full-text-url=https://sci-hub.do/10.1111/jpi.12525 }} * {{medline-title |title=Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30025494 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152523 }} * {{medline-title |title=Urine Cytokine and Chemokine Levels Predict Urinary Tract Infection Severity Independent of Uropathogen, Urine Bacterial Burden, Host Genetics, and Host Age. |date=09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29891542 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105902 }} * {{medline-title |title=Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice. |date=07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29758231 |full-text-url=https://sci-hub.do/10.1016/j.mad.2018.05.003 }} * {{medline-title |title=Time-Dependent Changes in Local and Serum Levels of Inflammatory Cytokines as Markers for Incised Wound Aging of Skeletal Muscles. |date=05.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29760352 |full-text-url=https://sci-hub.do/10.1620/tjem.245.29 }} * {{medline-title |title=Age-related pro-inflammatory and pro-angiogenic changes in human aqueous humor. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29487806 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824071 }} * {{medline-title |title=Immune senescence and biomarkers profile of Bambuí aged population-based cohort. |date=03.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29247791 |full-text-url=https://sci-hub.do/10.1016/j.exger.2017.12.006 }} * {{medline-title |title=Selected life-extending interventions reduce arterial [[CXCL10]] and macrophage colony-stimulating factor in aged mouse arteries. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28390264 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544385 }} * {{medline-title |title=Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats. |date=06.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28284714 |full-text-url=https://sci-hub.do/10.1016/j.mad.2017.03.001 }} * {{medline-title |title=Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension. |date=02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28017665 |full-text-url=https://sci-hub.do/10.1016/j.phrs.2016.12.032 }} * {{medline-title |title=An attenuated immune response by Schwann cells and macrophages inhibits nerve regeneration in aged rats. |date=09.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27459920 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2016.05.004 }} * {{medline-title |title=Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26973110 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2015.12.019 }} * {{medline-title |title=Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling. |date=02.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26924930 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766111 }} * {{medline-title |title=Alterations in Monocyte Phenotypes and Functions after a Hip Fracture in Elderly Individuals: A 6-Month Longitudinal Study. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26812523 |full-text-url=https://sci-hub.do/10.1159/000443142 }} * {{medline-title |title=Elevated Levels of Microbial Translocation Markers and [[CCL2]] Among Older HIV-1-Infected Men. |date=01.03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26494772 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747622 }} * {{medline-title |title=[[APOE]] Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. |date=07.10.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26446211 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605380 }} * {{medline-title |title=Colorectal cancer-promoting activity of the senescent peritoneal mesothelium. |date=06.10.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26284488 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745719 }} * {{medline-title |title=Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models. |date=24.09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26235435 |full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2015.07.070 }} * {{medline-title |title=Neuroimmune and Neuropathic Responses of Spinal Cord and Dorsal Root Ganglia in Middle Age. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26241743 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524632 }} * {{medline-title |title=Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26011191 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444306 }} * {{medline-title |title=[[CCL2]], [[CXCL8]], [[CXCL9]] and [[CXCL10]] serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees. |date=12.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25955863 |full-text-url=https://sci-hub.do/10.1111/1756-185X.12589 }} * {{medline-title |title=Senescent dermal fibroblasts enhance stem cell migration through [[CCL2]]/[[CCR2]] axis. |date=07.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25808810 |full-text-url=https://sci-hub.do/10.1111/exd.12701 }} * {{medline-title |title=Age-associated changes in basal NF-κB function in human CD4 T lymphocytes via dysregulation of PI3 kinase. |date=11.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25553802 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276789 }} * {{medline-title |title=IL-4 signaling drives a unique arginase /IL-1β microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Rα after traumatic spinal cord injury. |date=25.06.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24966389 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069360 }} * {{medline-title |title=Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24959140 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050637 }} * {{medline-title |title=Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization. |date=12.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24082075 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837976 }} * {{medline-title |title=Effects of ethanol on immune response in the brain: region-specific changes in adolescent versus adult mice. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24033454 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872252 }} ==CD14== * {{medline-title |title=Human innate immune cell crosstalk induces melanoma cell senescence. |date=30.08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32939325 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470184 }} * {{medline-title |title=Lipopolysaccharide binding protein is associated with CVD risk in older adults. |date=08.09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895891 |full-text-url=https://sci-hub.do/10.1007/s40520-020-01684-z }} * {{medline-title |title=Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. |date=02.09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887359 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504560 }} * {{medline-title |title=Changes in salivary microbial sensing proteins [[CD14]] and [[TLR2]] with aging. |date=07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529494 |full-text-url=https://sci-hub.do/10.1007/s00784-020-03274-9 }} * {{medline-title |title=Association of [[CD14]] with incident dementia and markers of brain aging and injury. |date=21.01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31818907 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108812 }} * {{medline-title |title=Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681320 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813416 }} * {{medline-title |title=Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31298565 |full-text-url=https://sci-hub.do/10.1089/cell.2019.0010 }} * {{medline-title |title=Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation. |date=09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31131542 |full-text-url=https://sci-hub.do/10.1111/hiv.12751 }} * {{medline-title |title=Wheat seed ageing viewed through the cellular redox environment and changes in pH. |date=06.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31092082 |full-text-url=https://sci-hub.do/10.1080/10715762.2019.1620226 }} * {{medline-title |title=Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals. |date=26.02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30586719 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957233 }} * {{medline-title |title=Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30408092 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224077 }} * {{medline-title |title=Innate and adaptive immune dysregulation in critically ill ICU patients. |date=05.07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29976949 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033948 }} * {{medline-title |title=Serum Zonulin and Endotoxin Levels in Exceptional Longevity versus Precocious Myocardial Infarction. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29896420 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963352 }} * {{medline-title |title=Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. |date=15.06.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29728510 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263173 }} * {{medline-title |title=Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age. |date=06.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29656328 |full-text-url=https://sci-hub.do/10.1007/s00436-018-5860-4 }} * {{medline-title |title=The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. |date=15.02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29449647 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833376 }} * {{medline-title |title=Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment. |date=01.02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29391069 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796498 }} * {{medline-title |title=Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™). |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29177909 |full-text-url=https://sci-hub.do/10.1007/s12015-017-9784-7 }} * {{medline-title |title=Acute Effects of Nitrate-Rich Beetroot Juice on Blood Pressure, Hemostasis and Vascular Inflammation Markers in Healthy Older Adults: A Randomized, Placebo-Controlled Crossover Study. |date=22.11.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29165355 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707742 }} * {{medline-title |title=Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. |date=02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29080277 |full-text-url=https://sci-hub.do/10.1111/rda.13091 }} * {{medline-title |title=Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28694811 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483450 }} * {{medline-title |title=HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble [[CD14]] or D-Dimer. |date=15.08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28696344 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513170 }} * {{medline-title |title=Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation. |date=09.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28707376 |full-text-url=https://sci-hub.do/10.1002/oby.21888 }} * {{medline-title |title=β -Microglobulin participates in development of lung emphysema by inducing lung epithelial cell senescence. |date=01.05.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28213472 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451601 }} * {{medline-title |title=Age-dependent cellular reactions of the human immune system of humanized NOD scid gamma mice on LPS stimulus. |date=04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28162006 |full-text-url=https://sci-hub.do/10.1177/1753425917690814 }} * {{medline-title |title=Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27907136 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132299 }} * {{medline-title |title=Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice. |date=01.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27866511 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319664 }} * {{medline-title |title=Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People? |date=01.06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27824677 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867134 }} * {{medline-title |title=Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging. |date=01.12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27756630 |full-text-url=https://sci-hub.do/10.1016/j.exger.2016.10.005 }} * {{medline-title |title=Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology. |date=02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27723233 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242297 }} * {{medline-title |title=Red Wine Prevents the Acute Negative Vascular Effects of Smoking. |date=01.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27633722 |full-text-url=https://sci-hub.do/10.1016/j.amjmed.2016.08.025 }} * {{medline-title |title=T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment. |date=15.07.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27073222 |full-text-url=https://sci-hub.do/10.1093/infdis/jiw146 }} * {{medline-title |title=Cytomegalovirus viral load within blood increases markedly in healthy people over the age of 70 years. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26734066 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700608 }} * {{medline-title |title=Elevated Levels of Microbial Translocation Markers and [[CCL2]] Among Older HIV-1-Infected Men. |date=01.03.2016 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|title=Age-related changes in the features of porcine adult stem cells isolated from adipose tissue and skeletal muscle. |date=01.10.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23864607 |full-text-url=https://sci-hub.do/10.1152/ajpcell.00151.2013 }} * {{medline-title |title=Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial. |date=12.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23682163 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814238 }} ==CORT== * {{medline-title |title=Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats. |date=10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33075214 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571994 }} * {{medline-title |title=Effects of age and social isolation on murine hippocampal 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|title=Reevaluation of immune activation in the era of cART and an aging HIV-infected population. |date=19.10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29046481 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846952 }} * {{medline-title |title=Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. |date=17.08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28817118 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596542 }} * {{medline-title |title=Age dependent differences in the kinetics of γδ T cells after influenza vaccination. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28700738 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507438 }} * {{medline-title |title=NAD and the aging process: Role in life, death and everything in between. |date=05.11.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27825999 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{{medline-title |title=Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31933915 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945175 }} * {{medline-title |title=Anti-cell growth and anti-cancer stem cell activity of the [[CDK4]]/6 inhibitor palbociclib in breast cancer cells. |date=05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31823286 |full-text-url=https://sci-hub.do/10.1007/s12282-019-01035-5 }} * {{medline-title |title=Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. |date=04.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692039 |full-text-url=https://sci-hub.do/10.1002/jcb.29493 }} * {{medline-title |title=Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. 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|title=Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. |date=15.08.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23707792 |full-text-url=https://sci-hub.do/10.1016/j.mce.2013.05.003 }} * {{medline-title |title=Oxidized low-density lipoprotein induces hematopoietic stem cell senescence. |date=09.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23620010 |full-text-url=https://sci-hub.do/10.1002/cbin.10121 }} ==EGFR== * {{medline-title |title=Type I Collagen Aging Increases Expression and Activation of [[EGFR]] and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33014812 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511549 }} * {{medline-title |title=Catalog of Lung Cancer Gene Mutations Among Chinese Patients. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850378 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417348 }} * {{medline-title |title=Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. |date=05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32323422 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253070 }} * {{medline-title |title=Comparative effectiveness and cost-effectiveness of three first-line [[EGFR]]-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267879 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141611 }} * {{medline-title |title=An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. |date=01.05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201167 |full-text-url=https://sci-hub.do/10.1016/j.jmb.2020.03.019 }} * {{medline-title |title=Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor 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to protect glioblastoma cells from DNA damage-induced senescence. |date=04.12.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30514230 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280426 }} * {{medline-title |title=An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis. |date=06.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30357574 |full-text-url=https://sci-hub.do/10.1007/s12035-018-1392-2 }} * {{medline-title |title=Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. |date=09.08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30096926 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121303 }} * {{medline-title |title=Novel drug-resistance mechanisms of pemetrexed-treated non-small cell lung cancer. |date=30.03.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29682186 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908287 }} * {{medline-title |title=Withanolide A extends 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{{medline-title |title=Thiamin concentration in geriatric hospitalized patients using frusemide. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24597996 |full-text-url=https://sci-hub.do/10.1080/21551197.2013.875501 }} * {{medline-title |title=4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts. |date=06.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24561579 |full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2014.02.015 }} * {{medline-title |title=Cellular senescence or [[EGF]]R signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). |date=01.11.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24047696 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895430 }} * {{medline-title |title=Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously 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{{medline-title |title=Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit. |date=01.02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31869241 |full-text-url=https://sci-hub.do/10.1152/ajpgi.00283.2019 }} * {{medline-title |title=Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654268 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925090 }} * {{medline-title |title=Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. |date=03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31615282 |full-text-url=https://sci-hub.do/10.1080/13506129.2019.1675623 }} * {{medline-title |title=Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the 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{{medline-title |title=Bioactive growth hormone in older men and women: It's relationship to immune markers and healthspan. |date=06.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28551577 |full-text-url=https://sci-hub.do/10.1016/j.ghir.2017.05.002 }} * {{medline-title |title=Retinal, [[NPY]]- and 5ht- inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus). |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28288865 |full-text-url=https://sci-hub.do/10.1016/j.neures.2017.03.005 }} * {{medline-title |title=Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. |date=01.03.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28138095 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374316 }} * {{medline-title |title=Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction. |date=04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28101970 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334538 }} * {{medline-title |title=Nerve growth factor-induced plasticity in medial prefrontal cortex interneurons of aged Wistar rats. |date=01.12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27664582 |full-text-url=https://sci-hub.do/10.1016/j.exger.2016.09.017 }} * {{medline-title |title=Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries. |date=31.03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27298812 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899900 }} * {{medline-title |title=Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet. |date=02.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26718202 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005876 }} * {{medline-title |title=Short photoperiod condition increases susceptibility to stress in adolescent male rats. |date=01.03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26655789 |full-text-url=https://sci-hub.do/10.1016/j.bbr.2015.12.002 }} * {{medline-title |title=Neuropeptide Y: An Anti-Aging Player? |date=11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26549884 |full-text-url=https://sci-hub.do/10.1016/j.tins.2015.08.012 }} * {{medline-title |title=Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26448274 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598162 }} * {{medline-title |title=Reduction in [[NPY]]-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment. |date=10.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26250996 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in mice by regulating meal frequency and portion size but not total food intake. |date=09.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24991043 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130825 }} * {{medline-title |title=Distribution of peptidergic populations in the human dentate gyrus (somatostatin [SOM-28, SOM-12] and neuropeptide Y [[[NPY]]]) during postnatal development. |date=10.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24965867 |full-text-url=https://sci-hub.do/10.1007/s00441-014-1929-2 }} * {{medline-title |title=Relative contribution of foetal and post-natal nutritional periods on feeding regulation in adult rats. |date=01.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24010762 |full-text-url=https://sci-hub.do/10.1111/apha.12163 }} * {{medline-title |title=Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats. |date=2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23614006 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629088 }} * {{medline-title |title=Nerve growth factor retrieves neuropeptide Y and cholinergic immunoreactivity in the nucleus accumbens of old rats. |date=08.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23540942 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2013.02.011 }} * {{medline-title |title=Aging and long-term caloric restriction regulate neuropeptide Y receptor subtype densities in the rat brain. |date=06.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23410741 |full-text-url=https://sci-hub.do/10.1016/j.npep.2013.01.001 }} ==WRN== * {{medline-title |title=The Impact of Vitamin C on Different System Models of Werner Syndrome. |date=17.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202145 |full-text-url=https://sci-hub.do/10.1089/ars.2020.8147 }} * {{medline-title |title=[[WRN]] modulates translation by influencing nuclear mRNA export in HeLa cancer cells. |date=14.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33054770 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557079 }} * {{medline-title |title=[[MIB1]]-mediated degradation of [[WRN]] promotes cellular senescence in response to camptothecin treatment. |date=09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652764 |full-text-url=https://sci-hub.do/10.1096/fj.202000268RRR }} * {{medline-title |title=A Case Report of Werner's Syndrome With a Novel Mutation From India. |date=08.05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32528764 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282380 }} * {{medline-title |title=Evidence for premature aging in a Drosophila model of Werner syndrome. |date=11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518666 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935377 }} * {{medline-title |title=Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31259468 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718529 }} * {{medline-title |title=Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. |date=06.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30666569 |full-text-url=https://sci-hub.do/10.1007/s10522-019-09798-2 }} * {{medline-title |title=Werner Syndrome Protein and DNA Replication. |date=02.11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30400178 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274846 }} * {{medline-title |title=A case report of Werner's syndrome with bilateral juvenile cataracts. |date=14.08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30107835 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092780 }} * {{medline-title |title=Genomic instability and DNA replication defects in progeroid syndromes. |date=31.12.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29936894 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000143 }} * {{medline-title |title=Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29908963 |full-text-url=https://sci-hub.do/10.1016/j.bbi.2018.06.007 }} * {{medline-title |title=Acidic domain of [[WRN]]p is critical for autophagy and up-regulates age associated proteins. |date=08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29800817 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338341 }} * {{medline-title |title=RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting. |date=07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29752965 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217841 }} * {{medline-title |title=Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29476423 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876188 }} * {{medline-title |title=Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant [[WRN]] protein. |date=07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29452565 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998970 }} * {{medline-title |title=Werner syndrome ([[WRN]]) gene variants and their association with altered function and age-associated diseases. |date=01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29146545 |full-text-url=https://sci-hub.do/10.1016/j.arr.2017.11.003 }} * {{medline-title |title=Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells. |date=28.01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29080750 |full-text-url=https://sci-hub.do/10.1016/j.canlet.2017.10.021 }} * {{medline-title |title=Recent Advances in Understanding Werner Syndrome. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29043077 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621106 }} * {{medline-title |title=Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. |date=19.09.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28934497 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766164 }} * {{medline-title |title=The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and [[FEN1]]-Mediated Flap Cleavage during Polymerase δ Elongation. |date=01.02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27849570 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247617 }} * {{medline-title |title=Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. |date=07.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27271327 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930768 }} * {{medline-title |title=Bloom's syndrome: Why not premature aging?: A comparison of the [[BLM]] and [[WRN]] helicases. |date=01.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27238185 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124422 }} * {{medline-title |title=Understanding Vascular Diseases: Lessons From Premature Aging Syndromes. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26948039 |full-text-url=https://sci-hub.do/10.1016/j.cjca.2015.12.003 }} * {{medline-title |title=Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging. |date=08.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26160351 |full-text-url=https://sci-hub.do/10.1089/rej.2015.1742 }} * {{medline-title |title=The Werner Protein Acts as a Coactivator of Nuclear Factor κB (NF-κB) on HIV-1 and Interleukin-8 (IL-8) Promoters. |date=24.07.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26037922 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513100 }} * {{medline-title |title=Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. |date=05.06.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25931448 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494668 }} * {{medline-title |title=Werner Syndrome-specific induced pluripotent stem cells: recovery of telomere function by reprogramming. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25688260 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310323 }} * {{medline-title |title=Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells. |date=12.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25257404 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582615 }} * {{medline-title |title=Senescence induced by [[RECQL4]] dysfunction contributes to Rothmund-Thomson syndrome features in mice. |date=15.05.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24832598 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047874 }} * {{medline-title |title=Search and insights into novel genetic alterations leading to classical and atypical Werner syndrome. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24401204 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997596 }} * {{medline-title |title=Hydrogen sulfide restores a normal morphological phenotype in Werner syndrome fibroblasts, attenuates oxidative damage and modulates mTOR pathway. |date=08.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23702336 |full-text-url=https://sci-hub.do/10.1016/j.phrs.2013.04.011 }} * {{medline-title |title=Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study. |date=01.02.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23329665 |full-text-url=https://sci-hub.do/10.1167/iovs.12-10948 }} * {{medline-title |title=The associations between single nucleotide polymorphisms of DNA repair genes, DNA damage, and age-related cataract: Jiangsu Eye Study. |date=01.02.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23322570 |full-text-url=https://sci-hub.do/10.1167/iovs.12-10940 }} * {{medline-title |title=Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome. |date=01.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23257959 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549877 }} ==KL== * {{medline-title |title=Alignment of Alzheimer's disease amyloid β-peptide and klotho. |date=11-12.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999998 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521834 }} * {{medline-title |title=PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. |date=07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32438247 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293549 }} * {{medline-title |title=Epigenetic Regulation of [[KL]] (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells. |date=05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223380 |full-text-url=https://sci-hub.do/10.1161/HYPERTENSIONAHA.120.14642 }} * {{medline-title |title=[[FGF23]] expression is stimulated in transgenic α-Klotho longevity mouse model. |date=05.12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801907 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962016 }} * {{medline-title |title=The goddess who spins the thread of life: Klotho, psychiatric stress, and accelerated aging. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30872092 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660403 }} * {{medline-title |title=[i][[KL]]OTHO[/i] heterozygosity attenuates [i]APOE4[/i]-related amyloid burden in preclinical AD. |date=16.04.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30867273 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550504 }} * {{medline-title |title=Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative. |date=03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30547410 |full-text-url=https://sci-hub.do/10.1007/s10439-018-02184-y }} * {{medline-title |title=Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. |date=01.02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30499713 |full-text-url=https://sci-hub.do/10.1152/ajpheart.00318.2018 }} * {{medline-title |title=Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis. |date=04.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30488497 |full-text-url=https://sci-hub.do/10.1002/em.22247 }} * {{medline-title |title=Klotho at the Edge of Alzheimer's Disease and Senile Depression. |date=03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29978424 |full-text-url=https://sci-hub.do/10.1007/s12035-018-1200-z }} * {{medline-title |title=Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29890178 |full-text-url=https://sci-hub.do/10.1016/j.mad.2018.06.002 }} * {{medline-title |title=G-395A polymorphism in the promoter region of the [[KL]]OTHO gene associates with frailty among the oldest-old. |date=30.04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29712948 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928057 }} * {{medline-title |title=Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of [[RIG]]-I/NF-κB Signaling. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29403373 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778393 }} * {{medline-title |title=Changes in expression of klotho affect physiological processes, diseases, and cancer. |date=01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29372030 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776433 }} * {{medline-title |title=Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29268200 |full-text-url=https://sci-hub.do/10.1016/j.jcrc.2017.11.023 }} * {{medline-title |title=Secreted αKlotho isoform protects against age-dependent memory deficits. |date=09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29086766 |full-text-url=https://sci-hub.do/10.1038/mp.2017.211 }} * {{medline-title |title=Induction of anti-aging gene klotho with a small chemical compound that demethylates CpG islands. |date=18.07.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28657902 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564520 }} * {{medline-title |title=Longevity 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of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16 inactivation. |date=26.02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29482580 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828408 }} * {{medline-title |title=Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study. |date=02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29143441 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771395 }} * {{medline-title |title=[[ARID1A]] suppresses malignant transformation of human pancreatic cells via mediating senescence-associated miR-503/[[[[CDKN2A]]]] regulatory axis. |date=18.11.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28942143 |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2017.09.099 }} * {{medline-title |title=Cellular Senescence in Mouse Hippocampus After Irradiation and the Role of p53 and p21. |date=01.04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28340115 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gene variants in a Czech Red Pied cattle population with reproductive traits. |date=02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901560 |full-text-url=https://sci-hub.do/10.1016/j.vetimm.2019.109997 }} * {{medline-title |title=Culture Model for Non-human Primate Choroid Plexus. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555096 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724611 }} * {{medline-title |title=Changes in fetal membrane histology with cervical insufficiency and transabdominal cerclage. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31004354 |full-text-url=https://sci-hub.do/10.1002/ijgo.12826 }} * {{medline-title |title=Aging leads to dysfunctional innate immune responses to [[TLR2]] and [[TLR4]] agonists. |date=09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30402800 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504629 }} * {{medline-title |title=The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30271656 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147589 }} * {{medline-title |title=Aging modulates microglia phenotypes in neuroinflammation of MPTP-PD mice. |date=01.10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30009921 |full-text-url=https://sci-hub.do/10.1016/j.exger.2018.07.010 }} * {{medline-title |title=Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice. |date=24.08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29929978 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109936 }} * {{medline-title |title=Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. |date=05.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29624852 |full-text-url=https://sci-hub.do/10.1002/cyto.a.23372 }} * {{medline-title |title=[[TLR4]] and [[TLR2]] activation is differentially associated with age during Parkinson's disease. |date=01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29077524 |full-text-url=https://sci-hub.do/10.1080/08820139.2017.1379024 }} * {{medline-title |title=Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. |date=01.11.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28801521 |full-text-url=https://sci-hub.do/10.1152/ajpheart.00106.2017 }} * {{medline-title |title=Ionizing radiation reduces [[ADAM10]] expression in brain microvascular endothelial cells undergoing stress-induced senescence. |date=04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28437250 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425125 }} * {{medline-title |title=Aging-related Atg5 defect impairs neutrophil extracellular traps formation. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28375544 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506403 }} * {{medline-title |title=Chronoinflammaging in Alzheimer; A systematic review on the roles of toll like receptor 2. |date=15.02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28087373 |full-text-url=https://sci-hub.do/10.1016/j.lfs.2017.01.003 }} * {{medline-title |title=Aged B cells alter immune regulation of allografts in mice. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27546296 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366259 }} * {{medline-title |title=Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26973103 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2016.01.002 }} * {{medline-title |title=Effects of aerobic training on markers of autophagy in the elderly. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26940016 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005904 }} * {{medline-title |title=Reduced levels of cytosolic DNA sensor [[AIM2]] are associated with impaired cytokine responses in healthy elderly. |date=06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26944367 |full-text-url=https://sci-hub.do/10.1016/j.exger.2016.02.016 }} * {{medline-title |title=Immune ageing and susceptibility to Streptococcus pneumoniae. |date=06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26472172 |full-text-url=https://sci-hub.do/10.1007/s10522-015-9614-8 }} * {{medline-title |title=Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26286603 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007736 }} * {{medline-title |title=Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice. |date=06.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25834936 |full-text-url=https://sci-hub.do/10.1016/j.patbio.2015.03.002 }} * {{medline-title |title=Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal [[TLR4]] activation in aged rats. |date=05.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25839444 |full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2015.02.008 }} * {{medline-title |title=Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. |date=05.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25797136 |full-text-url=https://sci-hub.do/10.1016/j.exger.2015.03.009 }} * {{medline-title |title=Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans. |date=12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25783173 |full-text-url=https://sci-hub.do/10.1007/s40520-015-0344-1 }} * {{medline-title |title=Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll-like receptor 2 and dietary flavonoid intake. |date=27.01.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25628407 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330067 }} * {{medline-title |title=Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis. |date=15.08.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24856731 |full-text-url=https://sci-hub.do/10.1016/j.vetimm.2014.04.004 }} * {{medline-title |title=Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24316110 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906490 }} * {{medline-title |title=Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride. |date=11.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23988651 |full-text-url=https://sci-hub.do/10.1016/j.exger.2013.08.006 }} * {{medline-title |title=Hypothalamic neuronal toll-like receptor 2 protects against age-induced obesity. |date=2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23409245 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570778 }} * {{medline-title |title=Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. |date=15.02.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23319733 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563860 }}
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