Редактирование: ARAP1

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) [CENTD2] [KIAA0782]

==Publications==

{{medline-entry
|title=Development of hypertension and kidney hypertrophy in transgenic mice overexpressing [[ARAP1]] gene in the kidney.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16801480
|abstract=Angiotensin II regulates blood pressure via activation of the type 1 receptor. We previously identified a novel angiotensin II type 1 receptor-associated protein and demonstrated that it promotes receptor recycling to the plasma membrane. To delineate the pathophysiological function of the [[ARAP1]] in the kidneys, we generated transgenic mice that overexpress rat [[ARAP1]] cDNA specifically in proximal tubules and tested the hypothesis that proximal tubule-specific overexpression of [[ARAP1]] causes hypertension. Two lines of male transgenic mice, 650 and 670, displayed kidney-specific transgene expression. Systolic blood pressure was significantly elevated by