Редактирование: AMBRA1

Activating molecule in BECN1-regulated autophagy protein 1 [KIAA1736]

==Publications==

{{medline-entry
|title=MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27191270
|abstract=Autophagy is a cellular catabolic mechanism that is activated in response to stress conditions, including ultraviolet (UV) irradiation, starvation, and misfolded protein accumulation. Abnormalities in autophagy are associated with several pathologies, including aging and cancer. Furthermore, recent studies have demonstrated that microRNAs (miRNAs) are potent modulators of the autophagy pathway. As a result, the current study aims to elucidate the role of the autophagy-related miRNA miR-23ain the process of photoaging. Experiments demonstrated that the antagomir-mediated inactivation of miR-23a resulted in the stimulation of PUVA- and UVB-depressed autophagy flux and protected human fibroblasts from premature senescence. Furthermore, [[AMBRA1]] was identified as a miR-23a target. [[AMBRA1]] cellular levels increased following the introduction of miR-23a antagomirs. And a bioinformatics analysis revealed that the [[AMBRA1]] 3' UTR contains functional miR-23a responsive sequences. Finally, it was also demonstrated that both [[AMBRA1]] overexpression and Rapamycin treatment were both able to rescue fibroblasts from PUVA and UVB irradiation-induced autophagy inhibition, but that these effects could also be mitigated by miR-23a overexpression. Therefore, this study concludes that miR-23a-regulated autophagy is a novel and important regulator of ultraviolet-induced premature senescence and [[AMBRA1]] is a rate-limiting miRNA target in this pathway.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Antagomirs
* Autophagy
* Cellular Senescence
* Fibroblasts
* Humans
* MicroRNAs
* Skin
* Skin Aging
* Skin Physiological Phenomena
* Transfection
|keywords=* AMBRA1
* Gerotarget
* autophagy
* miR-23a
* stress-induced premature senescence
* ultraviolet
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122322
}}