Редактирование: ADD1

Alpha-adducin (Erythrocyte adducin subunit alpha) [ADDA]

==Publications==

{{medline-entry
|title=Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18475162
|abstract=We investigated the possible association between left ventricular diastolic function and the [[ADD1]] Gly460Trp and [[ADD3]] IVS11  386A>G polymorphisms alone and in combination. In a family-based population study (473 subjects; 50.5% women; mean age 50.5 years), we measured early (Ea) and late (Aa) diastolic peak velocities of the mitral annulus by tissue Doppler imaging. In multivariate-adjusted analyses, we investigated phenotype-genotype associations, while accounting for confounders and family structure. Lateral Ea/Aa ratio was higher in [[ADD1]] Trp allele carriers than in GlyGly homozygotes (1.51 vs. 1.40; P = 0.005) and was lower in [[ADD3]] A allele carriers than in GG homozygotes (1.42 vs. 1.55; P = 0.005). The effects of [[ADD1]] on the lateral Ea and Ea/Aa weakened with older age (P < 0.05). The best fitting model for lateral Ea and Ea/Aa included [[ADD1]], [[ADD3]], and the three-way interaction term of both genes with age. Below the age of 50 years, the lateral Ea/Aa ratio was higher in [[ADD1]] Trp allele carriers than in GlyGly homozygotes (1.91 vs. 1.73; P = 0.006), particularly in the presence of [[ADD3]] GG homozygosity (2.46 vs. 1.80; P = 0.0008). In older subjects, these phenotype-genotype associations were not significant (P > 0.20). Transmission of the [[ADD1]] Trp allele to offspring was associated with higher lateral Ea ( 0.91; P = 0.026) and Ea/Aa ratio ( 0.23; P = 0.0008). Our population-based study demonstrated that left ventricular diastolic relaxation is modulated by genetic variation in [[ADD1]] and [[ADD3]]. This association was more prominent in younger subjects in whom longstanding environmental factors and ageing are less likely to mask genetic effects.
|mesh-terms=* Adult
* Aged
* Aging
* Belgium
* Blood Flow Velocity
* Calmodulin-Binding Proteins
* Diastole
* Female
* Genotype
* Humans
* Laser-Doppler Flowmetry
* Male
* Middle Aged
* Mitral Valve
* Polymorphism, Genetic
* Ventricular Function, Left

|full-text-url=https://sci-hub.do/10.1097/HJH.0b013e3282f97dcd
}}