Редактирование: ADAM9

Disintegrin and metalloproteinase domain-containing protein 9 precursor (EC 3.4.24.-) (ADAM 9) (Cellular disintegrin-related protein) (Meltrin-gamma) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) [KIAA0021] [MCMP] [MDC9] [MLTNG]

==Publications==

{{medline-entry
|title=[The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer's disease].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23627094
|abstract=To explore the effects of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with Alzheimer's disease. SAMP8 mice were randomly divided into four groups: PNS high-dosage group, PNS low-dosage group, huperzine A group and control group. The high-dosage group and low-dosage group were treated with 200 and 100 mg/kg PNS respectively per day and the huperzine A group was treated with 0.3 mg/kg huperzine A per day, all by intragastric administration for 8 consecutive weeks. The same volume of double distilled water was given to the control group. The activity of a-secretase was assayed by direct immunofluorescent method(DIF). Western blot was used to detect the content of alpha-secretase including [[ADAM9]], [[ADAM10]] and [[ADAM17]] proteins. The Relative Fluorescence Units (RFU) of PNS high-dosage and low-dosage groups were higher than that of control group (P < 0.01). The results of western blot showed that the level of [[ADAM9]] protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly higher than that of control group (P < 0.05) while the levels of [[ADAM10]] protein expression in PNS high-dosage, low-dosage and huperzine A groups was significantly lower than that of control group (P < 0.05), while level of [[ADAM17]] of huperzine A group was higher than that of control group (P < 0.05). PNS can increase activity of alpha-secretase in the brain of SAMP8 mouse via increasing the level of [[ADAM9]] protein expression.
|mesh-terms=* ADAM Proteins
* ADAM10 Protein
* ADAM17 Protein
* Aging
* Alzheimer Disease
* Amyloid Precursor Protein Secretases
* Amyloid beta-Protein Precursor
* Animals
* Blotting, Western
* Brain
* Disease Models, Animal
* Female
* Gene Expression Regulation, Enzymologic
* Membrane Proteins
* Mice
* Panax notoginseng
* Random Allocation
* Saponins


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