Редактирование: ADAM33

Disintegrin and metalloproteinase domain-containing protein 33 precursor (EC 3.4.24.-) (ADAM 33) [C20orf153] [UNQ873/PRO1891]

==Publications==

{{medline-entry
|title=Polymorphisms of the [[ADAM33]] gene are associated with accelerated lung function decline in asthma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15144468
|abstract=Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The [[ADAM33]] gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling. To investigate whether polymorphisms of the [[ADAM33]] gene are associated with accelerated lung function decline in patients with asthma. In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the [[ADAM33]] gene were analysed to estimate their effect on annual FEV(1) decline. The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV(1) (P<0.05). These findings suggest that a variant in [[ADAM33]] is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
|mesh-terms=* ADAM Proteins
* Adolescent
* Adult
* Aging
* Asthma
* Disease Progression
* Forced Expiratory Volume
* Genetic Predisposition to Disease
* Humans
* Longitudinal Studies
* Lung
* Metalloendopeptidases
* Polymorphism, Genetic
* Polymorphism, Single Nucleotide

|full-text-url=https://sci-hub.do/10.1111/j.1365-2222.2004.1938.x
}}