Редактирование: ZNF804A

Zinc finger protein 804A [C2orf10]

==Publications==

{{medline-entry
|title=[[ZNF804A]] may be associated with executive control of attention.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21040459
|abstract=[[ZNF804A]], encoding the transcription factor zinc-finger protein 804A, is a genome-wide supported psychosis gene associated with schizophrenia and bipolar disorder. However, only little information is available on the role of [[ZNF804A]] regarding the cognitive phenotype of psychosis. In this study, we investigated the relationship between the single-nucleotide polymorphism rs1344706 (A/C, A = risk allele) in [[ZNF804A]] and attention in 200 healthy volunteers. We used the attention network test, which was designed to separate the three main components of attention (alerting, orienting and executive control). Results showed a significant association with the executive control network: the A/A genotype and the A-allele were associated with increased reaction time when conflicting information was present. In contrast, rs1344706 was not related to alerting and orienting. These results suggest that the genome-wide supported psychosis risk variant of [[ZNF804A]] is associated with altered executive control (larger conflict effect), which is a potential endophenotype of psychotic disorders.
|mesh-terms=* Adult
* Aging
* Alleles
* Attention
* DNA
* Data Interpretation, Statistical
* Executive Function
* Female
* Genotype
* Humans
* Kruppel-Like Transcription Factors
* Male
* Nerve Net
* Neuropsychological Tests
* Orientation
* Polymorphism, Genetic
* Psychotic Disorders
* Reaction Time
* Regression Analysis
* Reverse Transcriptase Polymerase Chain Reaction
* Schizophrenia
* Sex Characteristics

|full-text-url=https://sci-hub.do/10.1111/j.1601-183X.2010.00657.x
}}