Редактирование: VRK3

serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3)

==Publications==

{{medline-entry
|title=[[VRK3]]-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18035061
|abstract=Vaccinia-related kinase 3 ([[VRK3]]), previously characterized as a direct activator of vaccinia H1-related (VHR) phosphatase, inactivates extracellular signal-regulated kinase (ERK) in the nucleus of neuronal cells. Here we show that [[VRK3]] is expressed in various other rodent tissues and in embryos, and regulates VHR phosphatase activity in these tissues. We observed colocalization of [[VRK3]] and VHR in the testis tissue and could detect protein complex containing [[VRK3]], VHR and ERK in immunoprecipitation analysis. Notably, the addition of recombinant [[VRK3]] protein to total protein lysates, obtained either from adult tissues or embryos, enhanced the phosphatase activity of VHR, but not the activity of MKP3. The results further indicate that the VHR-[[VRK3]] complex is a phosphatase-active form. In addition, we found that [[VRK3]] can regulate [[EGF]]-induced cellular growth signaling that is mediated by ERK activation. Our results suggest that in addition to neuronal cells, various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by [[VRK3]]-mediated VHR activity.
|mesh-terms=* Aging
* Animals
* Cell Line
* Dual Specificity Phosphatase 3
* Enzyme Activation
* Extracellular Signal-Regulated MAP Kinases
* Gene Expression Regulation, Developmental
* Gene Expression Regulation, Enzymologic
* MAP Kinase Signaling System
* Male
* Mice
* Organ Specificity
* Protein Binding
* Protein-Serine-Threonine Kinases
* RNA, Small Interfering
* Rats

|full-text-url=https://sci-hub.do/10.1016/j.bbamcr.2007.10.011
}}