Редактирование: THY1

Thy-1 membrane glycoprotein precursor (CDw90) (Thy-1 antigen) (CD90 antigen)

==Publications==

{{medline-entry
|title=The roles of [[THY1]] and integrin beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on [[THY1]] and integrin beta3 localization in mouse ovarian follicles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21228213
|abstract=The mechanism of theca cell layer formation in mammalian ovaries has not been elucidated. In the present study, we examined the roles of [[THY1]] and integrin beta3 in theca cell layer formation during mouse folliculogenesis. The localization pattern of [[THY1]] and integrin beta3 in adult mouse ovary was investigated immunohistochemically. The strongest [[THY1]] signal was observed in theca cell layers from secondary to preantral follicles, at which time theca cells have begun to participate in follicle formation. Integrin beta3 also localized to the theca cell layer of secondary to preantral follicles and showed a localization pattern similar to that of [[THY1]]. Moreover, the role of [[THY1]] in theca cell layer formation was examined using a follicle culture system. When anti-[[THY1]] antibody was added to this culture, no theca cell layers were formed, and the granulosa cells were distanced from each other. Because a [[THY1]] signal was not observed in ovaries at stages earlier than prepuberty, [[THY1]] localization also appeared to be affected by mouse development. This possibility was examined by determining the effect of administering follicle-stimulating hormone, luteinizing hormone, and 17beta-estradiol to 7-day-old mice on [[THY1]] localization in the ovary 3 days later. Only follicle-stimulating hormone induced a [[THY1]] signal in 10-day-old mouse ovaries. No [[THY1]] signal was observed in untreated 10-day-old ovaries. In conclusion, [[THY1]] might play a role in cell adhesion via binding to integrin beta3 in mouse ovaries. The present results suggest that [[THY1]] localization may be affected by follicle-stimulating hormone in mouse ovaries.
|mesh-terms=* Aging
* Animals
* Cell Adhesion
* Estradiol
* Female
* Follicle Stimulating Hormone
* Immunohistochemistry
* Integrin beta3
* Luteinizing Hormone
* Mice
* Mice, Inbred ICR
* Organ Culture Techniques
* Organ Specificity
* Ovarian Follicle
* Theca Cells
* Thy-1 Antigens
* Up-Regulation

|full-text-url=https://sci-hub.do/10.1095/biolreprod.110.087429
}}