Редактирование: TBX2

T-box transcription factor TBX2 (T-box protein 2)

==Publications==

{{medline-entry
|title=The Highly Homologous T-Box Transcription Factors, [[TBX2]] and [[TBX3]], Have Distinct Roles in the Oncogenic Process.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21779450
|abstract=The T-box transcription factors [[TBX2]] and [[TBX3]] are overexpressed in several cancers and are able to bypass senescence by repressing ARF and p21(WAF1/CIP1/SDII). Although these studies suggest that they may both contribute to the oncogenic process by repressing common targets, whether they have redundant or distinct roles in cancers where they are both overexpressed remains to be elucidated. Importantly, when Tbx2 function is inhibited in melanoma cells lacking Tbx3, the cells senesce, but whether this is possible in melanoma cells overexpressing both proteins is not known. An understanding of this issue may have important implications for the design of an effective pro-senescence therapy. In this study, the authors used a sh-RNA approach to knock down [[TBX2]] and [[TBX3]] individually in 2 human melanoma cell lines that overexpress both these factors and then examined their specific involvement in the oncogenic process. They demonstrate, using in vitro and in vivo cell proliferation, as well as colony- and tumor-forming ability and cell motility assays, that [[TBX2]] and [[TBX3]] have distinct roles in melanoma progression. In the tested lines, although [[TBX2]] could promote proliferation and transformation and was required by primary melanoma cells for immortality, [[TBX3]] was required for tumor formation and cell migration. These findings were reproducible in a human breast cancer cell line, which confirms that [[TBX2]] and [[TBX3]], although highly homologous, do not have redundant roles in the transformation process of cancers where they are both overexpressed. These results have important implications for the development of new cancer treatments and in particular for melanoma, which is a highly aggressive and intractable cancer.

|keywords=* TBX2
* TBX3
* invasion
* melanoma
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092191
}}