Редактирование: SPG11

Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) [KIAA1840]

==Publications==

{{medline-entry
|title=[i]Malassezia[/i] and Parkinson's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396143
|abstract=Parkinson's disease (PD) is a common debilitating neurodegenerative disease caused by a loss of dopamine neurons in the substantia nigra within the central nervous system (CNS). The process leading to this neuronal loss is poorly understood. Seborrheic dermatitis (SD) is a common benign inflammatory condition of the skin which mainly affects lipid-rich regions of the head and trunk. SD is caused by over proliferation of the lipophilic fungus [i]Malassezia[/i]. PD and SD are strongly associated. The increased PD risk following an SD diagnosis (OR = 1.69, 95% CI 1.36, 2.1; [i]p[/i] < 0.001) reported by Tanner and colleagues remains unexplained. [i]Malassezia[/i] were historically considered commensals confined to the skin. However, many recent studies report finding [i]Malassezia[/i] in internal organs, including the CNS. This raises the possibility that [i]Malassezia[/i] might be directly contributing to PD. Several lines of evidence support this hypothesis. AIDS is causally associated with both parkinsonism and SD, suggesting that weak T cell-mediated control of commensal microbes such as [i]Malassezia[/i] might contribute to both. Genetic polymorphisms associated with PD ([i]LRRK2, [[GBA]], [[PINK1]], [[SPG11]], SNCA[/i]) increase availability of lipids within human cells, providing a suitable environment for [i]Malassezia[/i]. Four [i]LRRK2[/i] polymorphisms which increase PD risk also increase Crohn's disease risk; Crohn's disease is strongly associated with an immune response against fungi, particularly [i]Malassezia[/i]. Finally, [i]Malassezia[/i] hypha formation and melanin synthesis are stimulated by L-DOPA, which could promote [i]Malassezia[/i] invasiveness of dopamine neurons, and contribute to the accumulation of melanin in these neurons. Although [i]Malassezia[/i]'s presence in the substantia nigra remains to be confirmed, if [i]Malassezia[/i] play a role in PD etiology, antifungal drugs should be tested as a possible therapeutic intervention.

|keywords=* Malassezia
* Parkinson's disease
* immunodeficiency
* immunosenescence
* seborrheic dermatitis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667642
}}