Редактирование: S100A14

Protein S100-A14 (S100 calcium-binding protein A14) (S114) [S100A15]

==Publications==

{{medline-entry
|title=S100-mediated signal transduction in the nervous system and neurological diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16171556
|abstract=This article presents new information regarding the complement/level of S100 family members expressed in the brain and reviews the contribution of brain S100 family members to nervous system function and disease. A total of ten S100 family members are reported in the literature to be expressed in brain -[[S100A1]], [[S100A2]], [[S100A4]], [[S100A5]], [[S100A6]], [[[[S100A1]]0]], [[S100A1]]1, [[[[S100A1]]3]], [[S100B]], and [[S100Z]]. Quantitative Northern blot analysis detected no [[S100A3]], [[S100A8]], [[S100A9]] or [[S100A1]]4 mRNA in mouse brain suggesting that these family members are not expressed in the brain. In addition, there was a 100-fold range in the mRNA levels for the six family members that were detected in mouse brain: [[S100A1]]/[[S100B]] levels were 5-fold higher than [[S100A6]]/[[[[S100A1]]0]] levels and 100-fold higher than [[S100A4]]/[[[[S100A1]]3]] levels. Five of these six family members (S1100A1, [[S100A6]], [[[[S100A1]]0]], [[[[S100A1]]3]], and [[S100B]]) exhibited age-dependent increases in expression in adult mice that ranged from 5- to 20-fold. Although previous studies on S100 function in the nervous system have focused on [[S100B]], other family members ([[S100A1]], [[S100A3]], [[S100A4]], [[S100A5]]) have been implicated in neurological diseases. Like [[S100B]], intra- and inter-cellular forms of these family members have been linked to cell growth, cell differentiation, and apoptotic pathways. Studies presented here demonstrate that ablation of [[S100A1]] expression in PC12 cells results in increased resistance to Abeta peptide induced cell death, stabilization of intracellular [Ca2 ] homeostasis, and reduced amyloid precursor protein expression. Altogether, these results confirm that S100-mediated signal transduction pathways play an important role in nervous system function/disease and implicate [[S100A1]] in the neuronal cell dysfunction/death that occurs in Alzheimer's disease.
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Amyloid beta-Protein Precursor
* Animals
* Apoptosis
* Brain Chemistry
* Calcium
* Cell Differentiation
* Cell Line
* Cell Proliferation
* Gene Expression Regulation
* Homeostasis
* Mice
* Mice, Inbred C57BL
* Nervous System Diseases
* Nervous System Physiological Phenomena
* Neurons
* Peptide Fragments
* S100 Proteins
* Signal Transduction


}}