Редактирование: NINL

Ninein-like protein [KIAA0980] [NLP]

==Publications==

{{medline-entry
|title=Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21234692
|abstract=Traditional tests used in the clinic to identify dementia, such as the mini-mental state examination (MMSE), are useful to identify severe cognitive impairments but might be less sensitive to detect more subtle age-related cognitive changes. Previously, the novel image-novel location ([[NINL]]) object recognition test was shown to be sensitive to detect effects of apolipoprotein E4, a risk factor for developing age-related cognitive decline and Alzheimer's disease, in nondemented elderly. In the present longitudinal study, performance on the MMSE and the [[NINL]] tests were compared over a 4-year period. Individual [[NINL]] scores over this period were highly correlated. In addition, while MMSE scores did not change over the 4-year period, [[NINL]] scores did. In a final testing session of a subset of the participants, [[NINL]] scores correlated with logical memory and word recall lists, cognitive tasks used to detect dementia in the clinic, as well as clinical dementia rating scales. These results support that the [[NINL]] might be a valuable tool to assess age-related cognitive decline.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Biomarkers
* Cognition Disorders
* Humans
* Longitudinal Studies
* Neuropsychological Tests
* Oregon
* Psychiatric Status Rating Scales
* Risk Factors

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260359
}}
{{medline-entry
|title=Effects of epsilon4 on object recognition in the non-demented elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20044903
|abstract=Previously we reported that apolipoprotein E (ApoE) epsilon4 negatively affects performance in the novel-image-novel-location ([[NINL]]) object recognition test in healthy non-demented elderly human study participants. In this study, the participants were invited to return for testing sessions 6 and 18 months after the baseline session. Using a longitudinal study design, effects of epsilon4 on [[NINL]] test performance were assessed in study "dropouts", participants that did not return for the second and/or third session(s), and "finishers", participants that returned for all sessions. There were effects of epsilon4 on dropout rates and [[NINL]] total scores as well as sub-scores in both dropouts and finishers. [[NINL]] total score was a predictor of epsilon4 participant dropout. Compared to non-epsilon4 dropouts, epsilon4 dropouts had lower [[NINL]] scores. In contrast, epsilon4 finishers had higher [[NINL]] scores than non-epsilon4 finishers. Thus, the [[NINL]] test could be a valuable tool in detecting pre-clinical signs of age-related cognitive impairments, particularly those associated with epsilon4 risk.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Chi-Square Distribution
* Cognition
* Cortisone
* Female
* Genotype
* Geriatric Assessment
* Humans
* Logistic Models
* Longitudinal Studies
* Male
* Memory
* Middle Aged
* Neuropsychological Tests
* Oregon
* Patient Dropouts
* Phenotype
* Recognition, Psychology
* Risk Assessment
* Risk Factors
* Saliva
* Testosterone
* Time Factors

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849126
}}