Редактирование: NALCN

Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) [VGCNL1]

==Publications==

{{medline-entry
|title=A sodium leak current regulates pacemaker activity of adult central pattern generator neurons in Lymnaea stagnalis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21526173
|abstract=The resting membrane potential of the pacemaker neurons is one of the essential mechanisms underlying rhythm generation. In this study, we described the biophysical properties of an uncharacterized channel (U-type channel) and investigated the role of the channel in the rhythmic activity of a respiratory pacemaker neuron and the respiratory behaviour in adult freshwater snail Lymnaea stagnalis. Our results show that the channel conducts an inward leak current carried by Na( ) (I(Leak-Na)). The I(Leak-Na) contributed to the resting membrane potential and was required for maintaining rhythmic action potential bursting activity of the identified pacemaker RPeD1 neurons. Partial knockdown of the U-type channel suppressed the aerial respiratory behaviour of the adult snail in vivo. These findings identified the Na( ) leak conductance via the U-type channel, likely a [[NALCN]]-like channel, as one of the fundamental mechanisms regulating rhythm activity of pacemaker neurons and respiratory behaviour in adult animals.
|mesh-terms=* Aging
* Amino Acid Sequence
* Animals
* Behavior, Animal
* Biological Clocks
* Calcium
* Cell Membrane
* Cell Separation
* Electricity
* Extracellular Space
* Gadolinium
* Gene Knockdown Techniques
* Ion Channel Gating
* Lymnaea
* Membrane Potentials
* Molecular Sequence Data
* Neurons
* RNA, Double-Stranded
* Sequence Alignment
* Sodium Channels

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079709
}}