Редактирование: M6PR

Cation-dependent mannose-6-phosphate receptor precursor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) [MPR46] [MPRD]

==Publications==

{{medline-entry
|title=Developmental expression of the IGF-II/mannose 6-phosphate receptor.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/8398120
|abstract=The first indication that the insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/[[M6PR]]) is developmentally regulated came from studies of the serum form of the receptor in the rat. By immunoblotting, the circulating form of the receptor, which was 10 kDa smaller than the tissue receptor, was high in 19 day fetal and 3, 10, and 20 day postnatal sera and then declined sharply. We next used quantitative immunoblotting to measure the total tissue IGF-II/[[M6PR]] in the rat. The receptor levels were high in fetal tissues and in most tissues declined dramatically in late gestation and/or in the early postnatal period. The rank order of receptor expression was heart > placenta > lung = intestine > muscle = kidney > liver > brain. In heart, the receptor was 1.7% of total protein in the extract. More recently, we have examined the expression of IGF-II/[[M6PR]] mRNA using Northern blotting and a solution hybridization/RNase protection assay. The rank order of receptor mRNA concentration among fetal tissues agreed with the rank order of receptor protein. The concentration of receptor mRNA was significantly lower in postnatal tissue than in fetal tissue. Thus IGF-II/[[M6PR]] mRNA concentration is an important determinant of receptor protein in most tissues. What is the function of the IGF-II/[[M6PR]] in embryonic and fetal tissues? The [[M6PR]] in birds and frogs does not bind IGF-II. It is intriguing that the rat IGF-II/[[M6PR]] is prominent during the embryonic and fetal periods, times at which the differences between mammals, on the one hand, and frogs and birds, on the other, are most striking.(ABSTRACT TRUNCATED AT 250 WORDS)
|mesh-terms=* Aging
* Animals
* Embryonic and Fetal Development
* Gene Expression Regulation
* Organ Specificity
* RNA, Messenger
* Rats
* Receptor, IGF Type 2

|full-text-url=https://sci-hub.do/10.1002/mrd.1080350415
}}