Редактирование: LRP8

Low-density lipoprotein receptor-related protein 8 precursor (LRP-8) (Apolipoprotein E receptor 2) [APOER2]

==Publications==

{{medline-entry
|title=SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating [[LRP8]] and ApoE.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31269452
|abstract=RNA binding proteins, the key regulators in gene expression at the posttranscriptional level, remain largely uncharacterized with respect to aging and relevant cognitive deterioration. Here, we report that the levels of SFRS11 are substantially decreased in the prefrontal cortex (PFC) of aged brains. Notably, mice with SFRS11 deficiency in the PFC show impaired learning and memory. We demonstrate that SFRS11 directly binds to the 3' UTR of [[LRP8]] mRNA, as well as to the third exon of apoE mRNA, resulting in stabilization of these mRNAs, eventually deactivating JNK signaling. Importantly, restoration of [[LRP8]] and apoE reduces JNK signaling that is significantly enhanced in SFRS11-deficient cells. In addition, [[LRP8]] and apoE rescue aging-like phenotypes induced by SFRS11 loss. Our findings demonstrate that age-dependent loss of SFRS11 in the PFC reduces levels of apoE and [[LRP8]], leading to activation of the JNK pathway, ultimately influencing cognitive deficits.
|mesh-terms=* 3' Untranslated Regions
* Aging
* Animals
* Apolipoproteins E
* Cell Line
* Cognitive Dysfunction
* Exons
* Gene Knockdown Techniques
* Gene Ontology
* Humans
* LDL-Receptor Related Proteins
* MAP Kinase Kinase 4
* MAP Kinase Signaling System
* Maze Learning
* Memory
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Neurons
* Prefrontal Cortex
* Serine-Arginine Splicing Factors
* Signal Transduction
|keywords=* ApoE
* LRP8
* PFC
* SFRS11
* aging
* cognitive decline
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.06.002
}}