Редактирование: LILRB1

Leukocyte immunoglobulin-like receptor subfamily B member 1 precursor (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD85j antigen) [ILT2] [LIR1] [MIR7]

==Publications==

{{medline-entry
|title=Natural killer receptors distribution in multiple sclerosis: Relation to clinical course and interferon-beta therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20580616
|abstract=NK cell receptors (NKR) are expressed in subsets of NK and CD8  T cells, lymphocytes involved in multiple sclerosis (MS) pathogenesis. Clinical implications of NKR expression in MS are unknown. Here, we show that the proportions of CD8  T cells displaying [[LILRB1]], an inhibitory NKR expressed at late stages of T cell differentiation, were directly related with age and MS duration, and inversely with the immunomodulatory therapy-dependent increase of CD56(bright) NK cells. Similar associations were found for KIR  and CD56  CD8  T cells, whereas no age-related NKR distribution was perceived in controls. Moreover, active MS had lower [[LILRB1]]  NK cells, and IFN-β-treated patients exhibited a phenotypic profile related to shorter disease evolution. Progressive accumulation of terminally differentiated T lymphocytes and experienced NK cells in MS, presumably stimulated in response to a persistent challenge and modulated by IFN-β therapy, may support the analysis of NKR distribution as new biomarkers.
|mesh-terms=* Adult
* Aging
* Antibodies
* Antigens, CD
* Biomarkers
* CD56 Antigen
* CD8-Positive T-Lymphocytes
* Cell Count
* Cytomegalovirus Infections
* Female
* Humans
* Interferon-beta
* Killer Cells, Natural
* Leukocyte Immunoglobulin-like Receptor B1
* Leukocytes, Mononuclear
* Lymphocytes
* Male
* Middle Aged
* Multiple Sclerosis
* Multiple Sclerosis, Chronic Progressive
* Multiple Sclerosis, Relapsing-Remitting
* NK Cell Lectin-Like Receptor Subfamily C
* Receptors, Immunologic
* Receptors, KIR
* Receptors, Natural Killer Cell
* Recurrence
* Time Factors

|full-text-url=https://sci-hub.do/10.1016/j.clim.2010.06.002
}}