Редактирование: LGR4

Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48) [GPR48]

==Publications==

{{medline-entry
|title=Conditional knockout of Lgr4 leads to impaired ductal elongation and branching morphogenesis in mouse mammary glands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21791950
|abstract=We have analyzed the function of [[LGR4]] in the development of various mouse epithelial tissues. Here we first report the retarded invasion of mammary ducts into the fat pad observed in Lgr4(K5 KO) mice at 4 weeks, compared with that of age-matched Lgr4(K5 ctrl). Furthermore, we demonstrate a significant decrease in mammary ductal branching in Lgr4(K5 KO) at several stages (4, 6 and 8 weeks). On the other hand, immunohistochemical analysis of the mammary gland of Lgr4(K5 KO) using anti-αSMA, anti-K18 and anti-laminin antibodies showed structures similar to those of Lgr4(K5 ctrl) mammary glands. In addition, we did not detect significant differences in the expression of ERα, which was suggested to be a downstream molecule of [[LGR4]], and Lgr4(K5 KO) showed no retarded invasion in the response to 17β-estradiol administration. Furthermore, the phosphorylated form of Smad1/5/8 was normally detected in the mammary gland of Lgr4(K5 KO).
|mesh-terms=* Aging
* Animals
* Epithelial Cells
* Estrogen Receptor alpha
* Female
* Mammary Glands, Animal
* Mice
* Mice, Knockout
* Morphogenesis
* Ovariectomy
* Receptors, G-Protein-Coupled
* Reverse Transcriptase Polymerase Chain Reaction

|full-text-url=https://sci-hub.do/10.1159/000329476
}}