Редактирование: HMGCS2

Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase)

==Publications==

{{medline-entry
|title=The aged testis. A good model to find proteins involved in age-related changes of testis by proteomic analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24597284
|abstract=To explore associated proteins involved in age-related changes of the testis and better understand the roles of these proteins in the human testis. We used two-dimensional polyacrylamide gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight mass spec trometry analysis to identify differentially expressed proteins between the aged and the normal control groups. The L-lactate dehydrogenase C chain ([[LDHC]]) protein, a previous testis-specific protein, was found to be downregulated in the aged testis and was further tested with western blot and immunohistochemical analysis to verify the result of the [[LDHC]] protein in 2-DE. Twelve differentially expressed proteins were identified. Among those proteins, 3 were upregulated and 9 were downregulated in the aged group. The results of western blot and immunohistochemical analysis confirmed the expression of [[LDHC]] downregulation in the aged testis. Some proteins identified had little well-known function in the human testis, as follows: [[AKR7A3]], [[FDXR]], [[PGAM1]], SEPT2 and [[HMGCS2]]. Our results imply that the aged testis can be a good model to find associated proteins involved in age-related changes of the testis. It can be useful to understand the roles of those proteins in the testis.
|mesh-terms=* Aged
* Aging
* Down-Regulation
* Electrophoresis, Gel, Two-Dimensional
* Humans
* Immunohistochemistry
* Isoenzymes
* L-Lactate Dehydrogenase
* Male
* Middle Aged
* Proteins
* Proteomics
* Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
* Testis
* Young Adult


}}