Редактирование: FMO4

Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4) [FMO2]

==Publications==

{{medline-entry
|title=Quantitative analysis of FMO gene mRNA levels in human tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16183778
|abstract=The developmentally and tissue-specific expression of flavin-containing monooxygenase (FMO) enzymes has been previously characterized in a number of animal species, including humans, mice, rats, and rabbits. In this study, we used sensitive real-time reverse transcription-polymerase chain reaction methodology to systematically quantify the steady-state mRNA levels of [[FMO1]], 2, 3, 4, and 5 in human tissues. We examined the developmental regulation of these enzymes in brain tissue. [[FMO1]] was found to be down-regulated in human adult brain. The amount of other FMO mRNAs in human brains in different age groups was not significantly different. The study also provided a systematic quantitative comparison of the steady-state mRNA levels of [[FMO1]] to 5 in several major human organs (i.e., liver, lung, kidney, small intestine, and brain). The nature of the quantitative analysis allowed a comprehensive comparison of each FMO mRNA in different tissues as well as among FMO isoforms in the same tissue. A comparison between fetal liver and adult liver showed that [[FMO1]] was the only FMO that was down-regulated; all other FMOs had greater amounts of mRNA in adult liver. [[FMO5]] was the most prominent FMO form detected in fetal liver. The [[FMO5]] mRNA level was nearly as abundant as [[FMO3]] in adult liver. Whereas other FMOs displayed a significant, dominant tissue-specific mRNA profile (i.e., [[FMO1]] in kidney, [[FMO2]] in lung, [[FMO3]] and [[FMO5]] in adult liver), [[FMO4]] mRNA was observed more broadly at relatively comparable levels in liver, kidney, lung, and small intestine.
|mesh-terms=* Aging
* Brain
* Down-Regulation
* Female
* Humans
* Intestine, Small
* Isoenzymes
* Kidney
* Liver
* Lung
* Male
* Oxygenases
* RNA, Messenger
* Reverse Transcriptase Polymerase Chain Reaction

|full-text-url=https://sci-hub.do/10.1124/dmd.105.006171
}}