Редактирование: CRTAM

Cytotoxic and regulatory T-cell molecule precursor (Class-I MHC-restricted T-cell-associated molecule) (CD355 antigen)

==Publications==

{{medline-entry
|title=Role of [[CRTAM]] during mouse early T lymphocytes development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19799932
|abstract=[[CRTAM]] was reported as a novel receptor expressed in activated NKT and CD8 T lymphocytes. However, we have recently shown that it is also expressed in several non-immune tissues. In opposition to what has been stated for lymphoid cells, [[CRTAM]] expression is constitutive in epithelia, suggesting a role in cell-cell interactions. Given the importance of cell interactions during T lymphocyte development, we evaluated [[CRTAM]] during T lymphocyte ontogeny. Here we show that [[CRTAM]] has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development. [[CRTAM]] expression is restricted to CD8 and all DN subpopulations, with a consistent pattern from E13.5 stage to adult mice. Blocking [[CRTAM]] interaction with [[CADM1]] impairs thymus growth, uncovering a novel role in thymus development, with a consequent impact in thymocyte maturation. Thus, [[CRTAM]] interaction with [[CADM1]] is involved in structural maintenance of the thymic lobes.
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Immunoglobulins
* Mice
* Mice, Inbred C57BL
* Rats
* Rats, Sprague-Dawley
* T-Lymphocytes
* Thymus Gland
* Tissue Culture Techniques

|full-text-url=https://sci-hub.do/10.1016/j.dci.2009.09.009
}}