Редактирование: CCL28

C-C motif chemokine 28 precursor (Mucosae-associated epithelial chemokine) (MEC) (Protein CCK1) (Small-inducible cytokine A28) [SCYA28]

==Publications==

{{medline-entry
|title=Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32277312
|abstract=The chemokines [[CCL25]] and [[CCL28]], which promote immune cell migration, are primarily expressed in the small and large intestines and play critical roles in sustaining gut immunity. In particular, these chemokines are closely related to intestinal IgA secretion. However, there is no research regarding the effects of aging on [[CCL25]] and [[CCL28]] expression and function. Therefore, in the present study, we investigated the effects of aging on production of [[CCL25]] and [[CCL28]], and on gut immunity, especially IgA secretion, using young and aged female mice. By aging, the levels of small intestinal mRNA and protein of [[CCL25]] lowered, while these levels of [[CCL28]] in colon became higher. Moreover, the number of IgA-antibody secreting cells (IgA-ASCs) and total IgA concentration decreased in the small intestine due to the age-associated reduction of [[CCL25]]. In contrast, colonic IgA production was increased due to up-regulation of [[CCL28]], while the number of colonic IgA-ASCs was unchanged with aging. These results clearly demonstrate that aging-associated decrease in small intestinal [[CCL25]] production and increase in colonic [[CCL28]] production c be involved in aging-associated deterioration of gut immunity.

|keywords=* Aging
* CCL25
* CCL28
* Gut immunity
* IgA
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09877-9
}}