Редактирование: CASR

Extracellular calcium-sensing receptor precursor (CaR) (CaSR) (hCasR) (Parathyroid cell calcium-sensing receptor 1) (PCaR1) [GPRC2A] [PCAR1]

==Publications==

{{medline-entry
|title=Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11248745
|abstract=Bone mineral density (BMD) in adolescence is under strong genetic control. The calcium sensing receptor ([[CASR]]) is involved in the regulation of calcium homeostasis and bone resorption. The A986S polymorphism of the [[CASR]] has recently been associated with serum calcium levels, in one hitherto unconfirmed report. We investigated whether this polymorphism was related to BMD, circulating calcium and parathyroid hormone ([[PTH]]) concentrations in girls. BMD, plasma calcium and serum [[PTH]] were measured in adolescent girls and compared with regard to [[CASR]] genotype. In 97 healthy Caucasian girls (mean age 16.9 /-1.2 years (mean /-s.d.)), the A and S alleles were determined using PCR with a mismatched primer and the restriction enzyme BsaHI. BMD (g/cm) of the total body, humerus, femoral neck and lumbar spine was measured using dual energy X-ray absorptiometry. The genotype frequencies were 71% AA, 26% AS and 3% SS. The genotypes were divided into presence (29%) or absence of S allele (71%). Subjects with the S allele had higher levels of plasma calcium, corrected for albumin (2.17 /-0.06>2.14 /-0.06; P < 0.05, using independent samples t-test), lower BMD at the lumbar spine (P=0.02) and total body (P=0.04), and were significantly less physically active (2.9 /-2.6 vs 4.3 /-2.6 h/week; P=0.01) than the subjects lacking the S allele. [[PTH]] levels were not significantly different between the two allelic groups. A multiple regression analysis, including age, height, weight and physical activity, revealed that the [[CASR]] allelic variants were not independent predictors of BMD at any site measured (beta=-0.03-0.09; P>0.05). Physical activity was an independent predictor of BMD, was significantly different between the [[CASR]] genotypes, and could therefore have a role in explaining the difference in BMD between the [[CASR]] genotypes. The [[CASR]] alleles are related to BMD, but it cannot be definitely concluded whether the [[CASR]] polymorphism has a direct influence on BMD, or whether the differences in BMD were mediated via an influence of the amount of physical activity.
|mesh-terms=* Absorptiometry, Photon
* Adolescent
* Aging
* Alleles
* Body Height
* Body Weight
* Bone Density
* Calcium
* European Continental Ancestry Group
* Female
* Femur Neck
* Gene Frequency
* Genotype
* Health
* Humans
* Humerus
* Lumbar Vertebrae
* Menarche
* Osteocalcin
* Parathyroid Hormone
* Physical Exertion
* Polymerase Chain Reaction
* Polymorphism, Genetic
* Receptors, Calcium-Sensing
* Receptors, Cell Surface

|full-text-url=https://sci-hub.do/10.1530/eje.0.1440257
}}