LAMC2
Laminin subunit gamma-2 precursor (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma) [LAMB2T] [LAMNB2]
Publications[править]
Laminin 332 is an essential component of the dermal-epidermal junction, a highly specialized basement membrane zone that attaches the epidermis to the dermis and thereby provides skin integrity and resistance to external mechanical forces. Mutations in the LAMA3, LAMB3 and LAMC2 genes that encode the three constituent polypeptide chains, α3, β3 and γ2, abrogate or perturb the functions of laminin 332. The phenotypic consequences are diminished dermal-epidermal adhesion and, as clinical symptoms, skin fragility and mechanically induced blistering. The disorder is designated as junctional epidermolysis bullosa (JEB). This article delineates the signs and symptoms of the different forms of JEB, the mutational spectrum, genotype-phenotype correlations as well as perspectives for future molecular therapies.
MeSH Terms
- Aging
- Animals
- Autoantigens
- Basement Membrane
- Cell Adhesion
- Cell Adhesion Molecules
- Codon, Nonsense
- Epidermolysis Bullosa, Junctional
- Frameshift Mutation
- Genetic Association Studies
- Humans
- Laminin
- Mice
- Non-Fibrillar Collagens
- RNA Splice Sites
- Skin