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Adapter molecule crk (Proto-oncogene c-Crk) (p38)


Crack-cocaine dependence and aging: effects on working memory.

To compare the working memory (WM) performance of young adult crack-cocaine dependent users, healthy older adults, and a control group of healthy young adults. A total of 77 female participants took part in this study: 26 young adult crack-cocaine dependent users (CRK), 19 healthy older adults (HO), and 32 healthy younger adults (HC). All participants completed the N-back verbal task. A multivariate analysis of covariance was performed. The model included education, income, and medication use as covariates. A group effect (F6,140 = 7.192, p < 0.001) was found. Post-hoc analyses showed that the performance of the CRK and HO groups was reduced compared to the HC group in two N-back conditions. No differences between the HO and CRK groups on WM performance were found. CRK participants perform similar to HO participants on a WM task, despite the well-known effects of age on WM and the young age of CRK. These data point to a possible parallel between cognitive declines associated with crack use and developmental aging.

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Case-Control Studies
  • Cocaine-Related Disorders
  • Crack Cocaine
  • Female
  • Humans
  • Memory, Short-Term
  • Neuropsychological Tests
  • Young Adult