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Dermatopontin precursor (Tyrosine-rich acidic matrix protein) (TRAMP)

Publications[править]

Does the DSW Practice Doctorate Provide Opportunities for Closing Gaps in Gerontology?

The 2019 annual conference of the Group for the Advancement of Doctoral Education in Social Work (GADE) highlighted the increasing role that the Doctor of Social Work (DSW) degree is playing in social work education. Over the past 15 years, social work has followed suit with a number of other health and helping professions (PsyD, DNP, DPT, etc.) by expanding access to practice doctorate programs for professionals who are interested in doctoral-level training, but primarily have interest to remain working in the field as practitioners, rather than become researchers. As more DSW programs have emerged, questions and concerns persist about the DSW, with most questions pertaining to the meaning of the degree for the overall field and the value of having an additional advanced practice degree in social work beyond the MSW degree. However, I urge readers of the [i]Journal of Gerontological Social Work[/i] to consider the opportunities that the DSW may present for advancing gerontological education, research, and practice.

MeSH Terms

  • Education, Professional
  • Geriatrics
  • Humans
  • Professional Practice Gaps
  • Social Work

Keywords

  • Social work education
  • education
  • health care workforce
  • learning
  • professional workforce issues


Influence of season, age and management on scrotal thermal profile in Murrah bulls using scrotal infrared digital thermography.

The aim of the present study was to examine the effects of non-genetic factors on scrotal thermographic profile viz., proximal pole temperature (PPT °C), mid pole temperature (MPT °C), distal pole temperature (DPT °C) and ocular temperature (OcT) of Murrah (Bubalus bubalis) breeding bulls. A total of 109 buffalo bulls, maintained at three semen stations (SS), were monitored for scrotal surface and ocular temperatures using infrared thermography twice daily during rainy, winter and summer seasons using an FLIR i5 infrared camera and temperatures were measured. Thermograms were analysed by FLIR QuickReport v.1.2 SP2 software. Statistical analysis revealed that semen station, season, temperature humidity index (THI), housing system and timing of observations had significant (P < 0.05) effect on scrotal surface temperature (SST) and OcT. In SS-I, the PPT and MPT were significantly (P < 0.05) higher as compared to SS-II and SS-III. THI had significant (P < 0.05) effect on SST and OcT, whereas PPT (°C), MPT (°C), DPT (°C) and OcT (°C) values during high THI (>80.88; <0.05) period were higher as compared to medium THI period (70.06-80.88) and during low THI period (<70.06). Temperature gradient (TG) of the testes was significantly (P < 0.05) higher during low THI period (4.50 ± 0.06 °C) as compared to medium THI (2.38 ± 0.03 °C) and high THI (1.61 ± 0.05 °C). Season of the year had a significant effect (P < 0.05) on the SST and OcT. During the rainy season, PPT (34.50 ± 0.09 °C), MPT (33.44 ± 0.12 °C) and DPT (32.11 ± 0.15 °C) were significantly (P < 0.05) higher as compared to winter and summer seasons. Age of the bulls had non-significant effect on SST and OcT but had a marked influence on thermal profile of scrotum. It could be concluded semen station, season, temperature humidity index, housing system and timing of observations had a significant influence on scrotal surface temperature. The monitoring of scrotal surface temperature by infrared thermography was found to be useful in evaluating the effects of thermal stress on physiology and health of buffalo bulls.

MeSH Terms

  • Aging
  • Animals
  • Body Temperature
  • Buffaloes
  • Heat Stress Disorders
  • Housing, Animal
  • Humidity
  • Male
  • Scrotum
  • Seasons
  • Temperature
  • Thermography

Keywords

  • Infrared thermography
  • Murrah bulls
  • Scrotal thermographic profile
  • Season
  • THI


Effects of an integrated geriatric group balance class within an entry-level Doctorate of Physical Therapy program on students' perceptions of geriatrics and geriatric education in the United States.

This study was aimed at determining the effect of an integrated group balance class for community-dwelling older adults within entry-level physical therapist coursework on student perceptions of geriatric physical therapy and geriatric physical therapy education. Twenty-nine Doctor of Physical Therapy (DPT) students, 21-33 years old, in their second year of coursework in 2012, participated in an integrated clinical experience with exposure to geriatric patients at an outpatient facility at the Louis Stokes Cleveland Department of Veterans Affairs Medical Center in Akron, Ohio, USA. Student perceptions were collected before and after participation in the 8-week balance class. The Wilcoxon sign-ranked test was used to identify differences in perceptions after participation in the group balance class. Cohen's d values were calculated to measure the size of the pre-participation to post-participation effect for each measure. At the conclusion of the group class, the DPT students demonstrated an increase in positive perceptions of geriatric physical therapy in 8 measures, with small effect sizes (d=0.15-0.30). Two perceptions of geriatric physical therapy demonstrated a significant positive increase (P<.05) with moderate effect sizes (d=0.47 and d=0.50). The students' perceptions of geriatric education in the curriculum demonstrated a large positive effect for quality (d=1.68) and enjoyment (d=1.96). Positive changes were found in most of the perceptions of geriatrics and geriatric education after participation, suggesting that integrated clinical experiences with geriatric patients are an effective way to positively influence perceptions of physical therapist practice with older adults.

MeSH Terms

  • Aged
  • Attitude
  • Curriculum
  • Female
  • Geriatrics
  • Health Education
  • Hospitals, Veterans
  • Humans
  • Male
  • Ohio
  • Perception
  • Physical Therapists
  • Physical Therapy Modalities
  • Postural Balance
  • Students, Health Occupations
  • United States
  • Young Adult

Keywords

  • Adult
  • Geriatrics
  • Independent living
  • Physical therapists
  • United States


Auditory Temporal Processing Deficits in Chronic Stroke: A Comparison of Brain Damage Lateralization Effect.

There have been a few reports about the effects of chronic stroke on auditory temporal processing abilities and no reports regarding the effects of brain damage lateralization on these abilities. Our study was performed on 2 groups of chronic stroke patients to compare the effects of hemispheric lateralization of brain damage and of age on auditory temporal processing. Seventy persons with normal hearing, including 25 normal controls, 25 stroke patients with damage to the right brain, and 20 stroke patients with damage to the left brain, without aphasia and with an age range of 31-71 years were studied. A gap-in-noise (GIN) test and a duration pattern test (DPT) were conducted for each participant. Significant differences were found between the 3 groups for GIN threshold, overall GIN percent score, and DPT percent score in both ears (P ≤ .001). For all stroke patients, performance in both GIN and DPT was poorer in the ear contralateral to the damaged hemisphere, which was significant in DPT and in 2 measures of GIN (P ≤ .046). Advanced age had a negative relationship with temporal processing abilities for all 3 groups. In cases of confirmed left- or right-side stroke involving auditory cerebrum damage, poorer auditory temporal processing is associated with the ear contralateral to the damaged cerebral hemisphere. Replication of our results and the use of GIN and DPT tests for the early diagnosis of auditory processing deficits and for monitoring the effects of aural rehabilitation interventions are recommended.

MeSH Terms

  • Acoustic Stimulation
  • Adult
  • Age Factors
  • Aged
  • Audiometry, Pure-Tone
  • Auditory Cortex
  • Auditory Pathways
  • Auditory Perception
  • Auditory Perceptual Disorders
  • Auditory Threshold
  • Case-Control Studies
  • Cerebrum
  • Chronic Disease
  • Female
  • Functional Laterality
  • Humans
  • Male
  • Middle Aged
  • Pattern Recognition, Physiological
  • Psychoacoustics
  • Signal Detection, Psychological
  • Stroke
  • Time Factors

Keywords

  • Stroke
  • aging
  • auditory cerebrum
  • brain damage
  • gap in noise
  • temporal processing


In vitro and in vivo efficacy of Acorus calamus extract against Rhipicephalus (Boophilus) microplus.

To develop a environment friendly control measure against cattle tick, Rhipicephalus (Boophilus) microplus, medicinally important plants were identified and extracts were prepared. Twelve 95% ethanolic, thirteen 50% hydroethanolic and nine hot water extracts were prepared and tested against laboratory reared homogenous colony of R. (B.) microplus. Amongst the 34 extracts, 26 extracts showed no mortality within 72 h of application while 12.0 ± 4.9% to 35.0 ± 9.6% mortality of treated ticks was recorded in other extracts. Of the effective extracts, the extract prepared from rhizome of Acorus calamus proved highly efficacious and 100% final mortality within 14 DPT was recorded. The LC85 value of the extract was determined as 11.26. In vivo experiments confirmed the efficacy of the extract up to 42%, and repeat application was required after 7 DPT. The extract was found safe and no reaction was observed when animals were treated with 50% of the concentration, which was five times of the concentration used for in vivo studies. The possibility of using the extract for the control of cattle tick is discussed.

MeSH Terms

  • Acaricides
  • Acorus
  • Animals
  • Cattle
  • Cattle Diseases
  • Chromatography, High Pressure Liquid
  • Female
  • Larva
  • Longevity
  • Male
  • Oviposition
  • Parasitic Sensitivity Tests
  • Plant Extracts
  • Rabbits
  • Rhipicephalus
  • Skin
  • Tick Infestations
  • Toxicity Tests


Vitamin A supplementation of women postpartum and of their infants at immunization alters breast milk retinol and infant vitamin A status.

Vitamin A supplementation of lactating mothers and of infants at the time of diphtheria-pertussis-tetanus (DPT) and oral polio vaccine (OPV) immunizations have both been suggested as measures to prevent deficiency among infants. This multicenter randomized, double-blind, placebo-controlled trial was conducted in Ghana, India and Peru to determine the effect of maternal vitamin A supplementation on breast milk retinol and of maternal and infant supplementation on infant vitamin A status. Mothers in the intervention group received 60 mg vitamin A (as retinol palmitate) at 18-42 d postpartum; their infants were given 7.5 mg three times, i.e., at 6, 10 and 14 wk of age with DPT and OPV immunizations. Mothers and infants in the comparison group received a placebo. Maternal supplementation resulted in higher breast milk retinol at 2 mo postpartum [difference in means 7.1, 95% confidence interval (CI), 3.4, 10.8 nmol/g fat] and lower proportion of mothers with breast milk retinol < or = 28 nmol/g fat (15.2 vs. 26.6%, 95% CI of difference -16.6, -4.1%). At 6 and 9 mo, maternal supplementation did not affect breast milk retinol or the proportion of mothers with low breast milk retinol. Vitamin A supplementation of the mothers and their infants reduced the proportion of infants with serum retinol < or = 0.7 micro mol/L (30.4 vs. 37%, 95% CI of difference -13.7, 0.6%) and that with low vitamin A stores as indicated by the modified relative dose response (MRDR) > 0.06 (44.2 vs. 52.9%, 95% CI of difference -16.6, -0.9%) at 6 mo. Supplementation had no effect at 9 mo. The beneficial effect of supplementation on breast milk retinol and infants' vitamin A status varied by site. It was greatest in India followed by Ghana and Peru. At the doses used, maternal supplementation improved breast milk retinol status at 2 mo (P < 0.001) and maternal and infant supplementation modestly increased (P = 0.03) infant vitamin A status at 6 mo of age. Additional strategies to improve vitamin A status of 6- to 9-mo-old infants must be considered.

MeSH Terms

  • Adult
  • Aging
  • Dietary Supplements
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Double-Blind Method
  • Female
  • Ghana
  • Humans
  • Immunization Programs
  • India
  • Infant
  • Infant, Newborn
  • Male
  • Milk, Human
  • Nutritional Status
  • Peru
  • Placebos
  • Poliovirus Vaccine, Oral
  • Postpartum Period
  • Vitamin A
  • Vitamin A Deficiency


[The immunogenicity of vaccines against diphtheria, tetanus, pertussis and polio administered orally on the vaccinal calendar at the age of 2, 4 and 6 months and their coadministration with a hepatitis B vaccine at 0, 2 and 6 months].

The immunogenicity of oral diphtheria, pertussis, tetanus, (DPT) and polio vaccines was examined. Six hundred seventy-seven children (Group I) were given hepatitis B vaccine at 0, 2, and 6 months of age and the oral DPT-polio vaccines were administered at 2, 4 and 6 months of age. A control group of 731 children (Group II) received only oral DPT-polio vaccines. In both groups the vaccine efficacy against poliomyelitis was 96% for serotype I and 100% for serotype II. For serotype III, the vaccine efficacy was 98% and 97% for groups I and II, respectively. In both groups 97% of the children had antibodies against B. pertussis and all children were positive for tetanus and diphtheria. No immune interference between the oral DPT and polio vaccines and the hepatitis B vaccine when they were given simultaneously could be demonstrated as the immune response to the DPT and polio vaccines were identical in both groups. It can be concluded that the simultaneous administration of the hepatitis B vaccine with the DPT and polio vaccines did not interfere with the immune response to the other antigens.

MeSH Terms

  • Administration, Oral
  • Aging
  • Antibodies, Bacterial
  • Antibodies, Viral
  • Bordetella pertussis
  • Clostridium tetani
  • Corynebacterium diphtheriae
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Humans
  • Immunization Schedule
  • Infant
  • Infant, Newborn
  • Poliovirus
  • Poliovirus Vaccine, Oral


Postural hypotension and dizziness in a general aged population: a four-year follow-up of the Helsinki Aging Study.

To evaluate the frequency, risk factors, and prognostic significances of postural hypotension (PH) and dizziness on postural testing (DPT). A prospective cohort study. General community, The Helsinki (Finland) Aging Study. Persons of three age cohorts (75, 80, and 85 years, n = 569) were chosen randomly and followed for 4 years. Postal questionnaires, structured interview, extensive clinical and laboratory examinations, blood pressure (BP) changes in a postural test using different definitions for PH, history of dizziness, dizziness on testing postural blood pressure reactions (DPT), and date of death during a 4-year follow-up. The frequency of a fall in systolic blood pressure greater than 20 mm Hg or a fall in diastolic pressure greater than 10 mm Hg (PH-I) was 30.3%. Both criteria occurred simultaneously (PH-II) in 7.5%, and if dizziness on postural testing (DPT) was an additional symptom (PH-III), the prevalence was 2.6%. The overall prevalence of DPT was 19.7%. PH-I, PH-II, and DPT were also frequent among the healthy aged (26.6%, 6.6%, and 17.3%, respectively). The postural change in BP correlated inversely with the initial supine BP levels (systolic r = -.149, P < .001 and diastolic r = -.218, P < .001), but in persons with isolated systolic hypertension PH was rather less frequent (21.9% and 2.3%). DPT was more common in the subjects with heart failure (26.3%, P < .05), impaired exercise tolerance (NYHA III-IV) (33.7%, P < .05), and PH-II (37.2%, P < .05) compared with the healthy controls (17.3%). The 1-year mortality was higher in subjects with than without DPT (7.1% vs 4.8%, P < .05), but the difference was not significant after controlling for age and gender. PH-I, PH-II, and PH-III were not significantly related to 4-year mortality. In this study of older people in Helsinki, Finland, asymptomatic hypotensive postural BP reactions and DPT were found frequently among healthy older people, and they tended to be increased in people with some diseases. Neither PH nor DPT were of prognostic significance for mortality in this population.

MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Blood Pressure
  • Cohort Studies
  • Dizziness
  • Female
  • Finland
  • Follow-Up Studies
  • Humans
  • Hypotension, Orthostatic
  • Male
  • Prevalence
  • Prognosis
  • Survival Analysis


Developmental changes in pain expression in premature, full-term, two- and four-month-old infants.

The purpose of this study was to examine the behavioural responses of infants to pain stimuli across different developmental ages. Eighty infants were included in this cross-sectional design. Four subsamples of 20 infants each included: (1) premature infants between 32 and 34 weeks gestational age undergoing heel-stick procedure; (2) full-term infants receiving intramuscular vitamin K injection; (3) 2-month-old infants receiving subcutaneous injection for immunisation against DPT; and (4) 4-month-old infants receiving subcutaneous injection for immunisation against DPT. Audio and video recordings were made for 15 sec from stimulus. Cry analysis was conducted on the first full expiratory cry by FFT with time and frequency measures. Facial action was coded using the Neonatal Facial Action Coding System (NFCS). Results from multivariate analysis showed that premature infants were different from older infants, that full-term newborns were different from others, but that 2- and 4-month-olds were similar. The specific variables contributing to the significance were higher pitched cries and more horizontal mouth stretch in the premature group and more taut tongue in the full-term newborns. The results imply that the premature infant has the basis for communicating pain via facial actions but that these are not well developed. The full-term newborn is better equipped to interact with his caretakers and express his distress through specific facial actions. The cries of the premature infant, however, have more of the characteristics that are arousing to the listener which serve to alert the caregiver of the state of distress from pain.

MeSH Terms

  • Aging
  • Analysis of Variance
  • Crying
  • Facial Expression
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Injections
  • Pain


Comparative effects of age and sedation on sinus node automaticity and atrioventricular conduction.

Corrected sinus node recovery time (CSNRT) and atrioventricular node effective refractory period are longer in nonsedated adults than in sedated children at cardiac catheterization. We attempted to ascertain the relative contributions of age and catheterization sedation on these differences by studying adult beagles and beagle puppies previously instrumented with atrial pacing wires. We found that CSNRT was similar in adults and puppies prior to drug administration. CSNRT shortened significantly after meperidine, promethazine, and chlorpromazine (DPT) administration in both adult dogs and puppies. Atrioventricular node effective refractory period (AVERP) was shorter in puppies than adults prior to DPT, and did not shorten in in either group after DPT. These findings suggest that the difference between CSNRTs in children and adults can be at least partly explained by the sedation used in children. This is an important consideration when premedicating children for electrophysiologic studies, particularly in children with suspected sinus node dysfunction.

MeSH Terms

  • Aging
  • Animals
  • Dogs
  • Heart Conduction System
  • Heart Rate
  • Hypnotics and Sedatives
  • Sinoatrial Node