Beta-defensin 1 precursor (BD-1) (hBD-1) (Defensin, beta 1) [BD1] [HBD1]

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Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity.

The distribution of polymorphic variants of innate immunity genes TLR9 ( 2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(-20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(-52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases.

MeSH Terms

  • Adult
  • Aged, 80 and over
  • Aging
  • Alleles
  • DNA
  • Gene Frequency
  • Humans
  • Immunity, Innate
  • Longevity
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Signal Transduction
  • Toll-Like Receptor 9
  • Young Adult
  • beta-Defensins