https://transhumanist.ru/index.php?title=CSNK1G2&feed=atom&action=historyCSNK1G2 - История изменений2024-03-29T12:35:57ZИстория изменений этой страницы в викиMediaWiki 1.40.1https://transhumanist.ru/index.php?title=CSNK1G2&diff=3917&oldid=prevOdysseusBot: Новая страница: «Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2) [CK1G2] ==Publications== {{medline-entry |title=Casein kinase 1G2 suppresses necroptosis-promoted te...»2021-04-29T18:51:28Z<p>Новая страница: «Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2) [CK1G2] ==Publications== {{medline-entry |title=Casein kinase 1G2 suppresses necroptosis-promoted te...»</p>
<p><b>Новая страница</b></p><div>Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2) [CK1G2]<br />
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==Publications==<br />
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{{medline-entry<br />
|title=Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.<br />
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33206046<br />
|abstract=Casein kinases are a large family of intracellular serine/threonine kinases that control a variety of cellular signaling functions. Here we report that a member of casein kinase 1 family, casein kinase 1G2, [[CSNK1G2]], binds and inhibits the activation of receptor-interacting kinase 3, [[RIPK3]], thereby attenuating [[RIPK3]]-mediated necroptosis. The binding of [[CSNK1G2]] to [[RIPK3]] is triggered by auto-phosphorylation at serine 211/threonine 215 sites in its C-terminal domain. [[CSNK1G2]]-knockout mice showed significantly enhanced necroptosis response and premature aging of their testis, a phenotype that was rescued by either double knockout of the [i]Ripk3[/i] gene or feeding the animal with a [[RIPK1]] kinase inhibitor-containing diet. Moreover, [[CSNK1G2]] is also co-expressed with [[RIPK3]] in human testis, and the necroptosis activation marker phospho-[[MLKL]] was observed in the testis of old (>80) but not young men, indicating that the testis-aging program carried out by the [[RIPK3]]-mediated and [[CSNK1G2]]-attenuated necroptosis is evolutionarily conserved between mice and men.<br />
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|keywords=* aging<br />
* cell biology<br />
* mouse<br />
* necroptosis<br />
* protein kinase<br />
* reproductivity<br />
* testis<br />
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673785<br />
}}</div>OdysseusBot