Aging genes 10-19

C6[править]

Age-related impairment of autophagy in cervical motor neurons. / 05.12.2020 / PubMed / Full text
Evolution of the Aroma of Treixadura Wines during Bottle Aging. / 08.10.2020 / PubMed / Full text
D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. / 29.09.2020 / PubMed / Full text
Alcohol Extracts From [i]Ganoderma lucidum[/i] Delay the Progress of Alzheimer's Disease by Regulating DNA Methylation in Rodents. / 2019 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Population-Stratified Analysis of Bone Mineral Density Distribution in Cervical and Lumbar Vertebrae of Chinese from Quantitative Computed Tomography. / 09-10.2016 / PubMed / Full text
Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
Neonatal Benzo[a]pyrene Exposure Induces Oxidative Stress and DNA Damage Causing Neurobehavioural Changes during the Early Adolescence Period in Rats. / 2016 / PubMed / Full text
Variations in Occipitocervical and Cervicothoracic Alignment Parameters Based on Age: A Prospective Study of Asymptomatic Volunteers Using Full-Body Radiographs. / 01.12.2016 / PubMed / Full text
Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses Glioma Cell Growth. / 08.2016 / PubMed / Full text
Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
Age-related morphologic changes of the vertebral artery in the transverse process. Analysis by multidetector computed tomography angiography. / 01.09.2015 / PubMed / Full text
Engineering temporal accumulation of a low recalcitrance polysaccharide leads to increased C6 sugar content in plant cell walls. / 09.2015 / PubMed / Full text
The effects of age on the morphometry of the cervical spinal cord and spinal column in adult rats: an MRI-based study. / 10.2014 / PubMed / Full text
Spontaneous age-related cervical disc degeneration in the sand rat. / 06.2014 / PubMed / Full text
The proform of glia cell line-derived neurotrophic factor: a potentially biologically active protein. / 02.2014 / PubMed / Full text
Developmental biomechanics of the human cervical spine. / 05.04.2013 / PubMed / Full text

CD19[править]

The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort. / 2020 / PubMed / Full text
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. / 2020 / PubMed / Full text
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice. / 19.07.2020 / PubMed / Full text
Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice. / 28.01.2020 / PubMed / Full text
Stress-Induced Premature Senescence Promotes Proliferation by Activating the [i]SENEX[/i] and p16 /Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell Lymphoma / 18.11.2019 / PubMed / Full text
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. / 2018 / PubMed / Full text
Innate and adaptive immune dysregulation in critically ill ICU patients. / 05.07.2018 / PubMed / Full text
Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases. / 16.05.2018 / PubMed / Full text
Normal variation of bone marrow B-cell precursors according to age - reference ranges for studies in myelodysplastic syndromes in Brazil. / 09.2018 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics. / 27.07.2017 / PubMed / Full text
Immune biomarkers in older adults: Role of physical activity. / 2017 / PubMed / Full text
A lifetime aging study of human CD19 transgenic mice. / 06.2017 / PubMed / Full text
Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. / 08.2018 / PubMed / Full text
Alterations in B-cell subsets in pediatric patients with early atopic dermatitis. / 07.2017 / PubMed / Full text
Perturbed hematopoiesis in mice lacking ATMIN. / 20.10.2016 / PubMed / Full text
Effects of Ageing on the Immune System: Infants to Elderly. / 04.2016 / PubMed / Full text
Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. / 11.2015 / PubMed / Full text
[Effects of soluble egg antigen and adult worm antigen of Schistosoma japonicum on differentiation of effector B cells of mice]. / 10.2013 / PubMed

ECD[править]

Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age. / 03.2020 / PubMed / Full text
Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats. / 01.12.2019 / PubMed / Full text
The occurrence and dynamics of polychlorinated hydrocarbons in roe deer ([i]Capreolus capreolus[/i]) in South-western Slovakia. / 2019 / PubMed / Full text
Corneal thickness, endothelial cell density, and morphological and morphometric features of corneal endothelial cells in goats. / 10.2018 / PubMed / Full text
Endothelial cell density and characterization of corneal endothelial cells in the Tawny Owl (Strix aluco) using specular microscopy. / 03.2019 / PubMed / Full text
An autopsy case report: Differences in radiological images correlate with histology in Erdheim-Chester disease. / 06.2018 / PubMed / Full text
Community-based trials of mobile solutions for the detection and management of cognitive decline. / 06.2017 / PubMed / Full text
Evaluating age-related change in lip somatosensation using somatosensory evoked magnetic fields. / 2017 / PubMed / Full text
A novel method for examining corneal endothelial cell morphology in infants. / 06.2017 / PubMed / Full text
Analyses of Factors Affecting Endothelial Cell Density in an Eye Bank Corneal Donor Database. / 09.2016 / PubMed / Full text
Morphological Abnormalities of Schlemm's Canal in Primary Open-Angle Glaucoma From the Aspect of Aging. / 02.2016 / PubMed / Full text
[TEMPORAL ORDER DETERIORATION AND CIRCADIAN DISRUPTION WITH AGE]. / 2015 / PubMed
Age-Dependent Changes of the Temporal Order--Causes and Treatment. / 2016 / PubMed / Full text
Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold. / 06.2015 / PubMed / Full text
Specular microscopy to determine corneal endothelial cell morphology and morphometry in chinchillas (Chinchilla lanigera) in vivo. / 01.2015 / PubMed / Full text
Oncogene-induced senescence as a new mechanism of disease: the paradigm of erdheim-chester disease. / 2014 / PubMed / Full text
Comparison of endothelial cell density of organ cultured corneas with cornea donor study. / 06.2014 / PubMed / Full text
Donor age and factors related to endothelial cell loss 10 years after penetrating keratoplasty: Specular Microscopy Ancillary Study. / 12.2013 / PubMed / Full text
Evaluation of grafted patients with donor corneas that today are more than 100 years old. / 08.2014 / PubMed / Full text

KLF4[править]

CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. / 15.07.2020 / PubMed / Full text
Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation. / 25.06.2020 / PubMed / Full text
Soluble klotho regulates the function of salivary glands by activating KLF4 pathways. / 02.10.2019 / PubMed / Full text
Centenarians Overexpress Pluripotency-Related Genes. / 16.08.2019 / PubMed / Full text
A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. / 12.2018 / PubMed / Full text
miR-10a rejuvenates aged human mesenchymal stem cells and improves heart function after myocardial infarction through KLF4. / 30.05.2018 / PubMed / Full text
MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition. / 10.04.2018 / PubMed / Full text
Kruppel-like factor 4 regulates keratinocyte senescence. / 05.05.2018 / PubMed / Full text
Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. / 15.10.2017 / PubMed / Full text
ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. / 09.2017 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells. / 08.2017 / PubMed / Full text
Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. / 13.09.2016 / PubMed / Full text
Adipose-derived stem cells from lean and obese humans show depot specific differences in their stem cell markers, exosome contents and senescence: role of protein kinase C delta (PKCδ) in adipose stem cell niche. / 2016 / PubMed / Full text
KLF4 deletion alters gastric cell lineage and induces MUC2 expression. / 09.06.2016 / PubMed / Full text
Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text
Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4. / 09.2015 / PubMed / Full text
The Ets transcription factor EHF as a regulator of cornea epithelial cell identity. / 29.11.2013 / PubMed / Full text

MTR[править]

The effect of age and training status on oxygen uptake kinetics in women. / 07.2020 / PubMed / Full text
Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. / 03.2020 / PubMed / Full text
One-carbon metabolism gene polymorphisms are associated with cognitive trajectory among African-American adults. / 12.2019 / PubMed / Full text
Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region- and aging-induced variations. / 2018 / PubMed / Full text
Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio. / 11.2016 / PubMed / Full text
Development and aging of superficial white matter myelin from young adulthood to old age: Mapping by vertex-based surface statistics (VBSS). / 05.2016 / PubMed / Full text
Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats. / 23.02.2016 / PubMed / Full text
Nutritional habits, lifestyle, and genetic predisposition in cardiovascular and metabolic traits in Turkish population. / 06.2016 / PubMed / Full text
Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence. / 05.2016 / PubMed / Full text
Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age. / 2015 / PubMed / Full text
An in vivo study on brain microstructure in biological and chronological ageing. / 2015 / PubMed / Full text
White matter hyperintensities and normal-appearing white matter integrity in the aging brain. / 02.2015 / PubMed / Full text
Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging. / 09.2014 / PubMed / Full text
Magnetization transfer ratio relates to cognitive impairment in normal elderly. / 2014 / PubMed / Full text
Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter. / 08.2014 / PubMed / Full text
Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis. / 2014 / PubMed / Full text
Magnetization transfer imaging for in vivo detection of microstructural tissue changes in aging and dementia: a short literature review. / 2014 / PubMed / Full text
Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects. / 04.2014 / PubMed / Full text
Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study. / 08.2013 / PubMed / Full text

UCP2[править]

Potential Role of Leptin in Cardiac Steatosis Induced by Highly Saturated Fat Intake during Adolescence. / 10.2019 / PubMed / Full text
Effect of Initial Aging and High-Fat/High-Fructose Diet on Mitochondrial Bioenergetics and Oxidative Status in Rat Brain. / 11.2019 / PubMed / Full text
Decreased uncoupling protein 2 expression in aging retinal pigment epithelial cells. / 2019 / PubMed / Full text
The Role of Genetic Profile in Functional Performance Adaptations to Exercise Training or Physical Activity: A Systematic Review of the Literature. / 01.08.2019 / PubMed / Full text
G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. / 01.02.2019 / PubMed / Full text
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. / 21.06.2018 / PubMed / Full text
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. / 02.2018 / PubMed / Full text
Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis. / 06.2017 / PubMed / Full text
Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism. / 01.02.2017 / PubMed / Full text
Uncoupling protein 2 deficiency results in higher neutrophil counts and lower B-cell counts during aging in mice. / 11.2016 / PubMed / Full text
Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. / 2016 / PubMed / Full text
Uncoupling protein 2 protects mice from aging. / 09.2016 / PubMed / Full text
Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians. / 08.2016 / PubMed / Full text
Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains. / 07.08.2015 / PubMed / Full text
[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group]. / 2014 / PubMed
Activation of PPAR-γ by pioglitazone attenuates oxidative stress in aging rat cerebral arteries through upregulating UCP2. / 12.2014 / PubMed / Full text
Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. / 06.2014 / PubMed / Full text
Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway. / 04.2014 / PubMed / Full text
Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway. / 2013 / PubMed / Full text

ALDH2[править]

Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link? / 2019 / PubMed / Full text
Appropriate dose of ethanol exerts anti-senescence and anti-atherosclerosis protective effects by activating ALDH2. / 30.04.2019 / PubMed / Full text
Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue. / 02.2019 / PubMed / Full text
Telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde. / 02.2019 / PubMed / Full text
Aldehyde dehydrogenase 2 deficiency promotes atherosclerotic plaque instability through accelerating mitochondrial ROS-mediated vascular smooth muscle cell senescence. / 01.07.2019 / PubMed / Full text
ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway. / 12.10.2018 / PubMed / Full text
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung. / 21.04.2017 / PubMed / Full text
Complex inhibition of autophagy by mitochondrial aldehyde dehydrogenase shortens lifespan and exacerbates cardiac aging. / 08.2017 / PubMed / Full text
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence. / 07.2016 / PubMed / Full text
Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2. / 04.2016 / PubMed / Full text
Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. / 05.2016 / PubMed / Full text
Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1. / 19.01.2016 / PubMed / Full text
Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease. / 25.04.2015 / PubMed / Full text
Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse. / 07.2014 / PubMed / Full text
Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. / 06.2014 / PubMed / Full text
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. / 01.2014 / PubMed / Full text
Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance. / 2013 / PubMed / Full text
Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism. / 03-04.2013 / PubMed / Full text

CCR7[править]

Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. / 07.2020 / PubMed / Full text
Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma. / 2020 / PubMed / Full text
Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis. / 02.2020 / PubMed / Full text
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. / 16.09.2019 / PubMed / Full text
Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults. / 26.03.2019 / PubMed / Full text
Low IL-2 Expressing T Cells in Thalassemia Major Patients: Is It Immune Aging. / 10.2018 / PubMed / Full text
Abnormalities of age-related T cell senescence in Parkinson's disease. / 28.05.2018 / PubMed / Full text
Effects of lifelong training on senescence and mobilization of T lymphocytes in response to acute exercise. / 2018 / PubMed
Alteration of T Cell Subtypes in Beta-Thalassaemia Major: Impact of Ferritin Level. / 02.2016 / PubMed / Full text
Sirt6 regulates dendritic cell differentiation, maturation, and function. / 01.2016 / PubMed / Full text
Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues. / 2015 / PubMed / Full text
Age-related profiling of DNA methylation in CD8 T cells reveals changes in immune response and transcriptional regulator genes. / 19.08.2015 / PubMed / Full text
CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. / 01.07.2015 / PubMed / Full text
Impact of HIV on CD8 T cell CD57 expression is distinct from that of CMV and aging. / 2014 / PubMed / Full text
Trafficking phenotype and production of granzyme B by double negative B cells (IgG( )IgD(-)CD27(-)) in the elderly. / 06.2014 / PubMed / Full text
Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease. / 2013 / PubMed / Full text
Probiotic modulation of dendritic cell function is influenced by ageing. / 02.2014 / PubMed / Full text

CD86[править]

Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline. / 2019 / PubMed / Full text
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. / 07.2019 / PubMed / Full text
One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects: Results From the United Kingdom Arm of the NU-AGE Trial. / 2018 / PubMed / Full text
C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral Tolerance. / 2018 / PubMed / Full text
Immunoglobulin therapy ameliorates the phenotype and increases lifespan in the severely affected dystrophin-utrophin double knockout mice. / 12.2017 / PubMed / Full text
Melatonin: Antioxidant and modulatory properties in age-related changes during Trypanosoma cruzi infection. / 08.2017 / PubMed / Full text
Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging. / 01.12.2016 / PubMed / Full text
Functional exhaustion of CD4 T cells induced by co-stimulatory signals from myeloid leukaemia cells. / 12.2016 / PubMed / Full text
Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes. / 02.2016 / PubMed / Full text
Aging Converts Innate B1a Cells into Potent CD8 T Cell Inducers. / 15.04.2016 / PubMed / Full text
Expression of HLA-DR, CD80, and CD86 in Healthy Aging and Alzheimer's Disease. / 2015 / PubMed / Full text
Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors. / 30.03.2015 / PubMed / Full text
Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. / 05.2015 / PubMed / Full text
Aging is associated with increased regulatory T-cell function. / 06.2014 / PubMed / Full text
Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice. / 18.09.2013 / PubMed / Full text
Aging affects AO rat splenic conventional dendritic cell subset composition, cytokine synthesis and T-helper polarizing capacity. / 08.2013 / PubMed / Full text
Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of "inflamm-aging". / 03.2014 / PubMed / Full text
An age-related numerical and functional deficit in CD19( ) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity. / 10.2013 / PubMed / Full text

CDK2[править]

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage. / 10.10.2020 / PubMed / Full text
Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway. / 11.2020 / PubMed / Full text
p57 is a master regulator of human adipose derived stem cell quiescence and senescence. / 04.2020 / PubMed / Full text
Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes. / 01.11.2019 / PubMed / Full text
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. / 22.05.2020 / PubMed / Full text
Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review. / 2019 / PubMed / Full text
Tenovin-1 Induces Senescence and Decreases Wound-Healing Activity in Cultured Rat Primary Astrocytes. / 01.05.2019 / PubMed / Full text
Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training. / 01.09.2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress. / 20.02.2018 / PubMed / Full text
Inhibition of CIP2A attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma. / 08.01.2018 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Pneumolysin induces cellular senescence by increasing ROS production and activation of MAPK/NF-κB signal pathway in glial cells. / 04.2017 / PubMed / Full text
The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging. / 12.2016 / PubMed / Full text
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. / 09.2016 / PubMed / Full text
Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine. / 22.01.2016 / PubMed / Full text
Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue. / 09.2015 / PubMed / Full text

CDK6[править]

D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. / 29.09.2020 / PubMed / Full text
Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. / 24.09.2020 / PubMed / Full text
Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. / 15.08.2020 / PubMed / Full text
Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. / 05.2020 / PubMed / Full text
Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. / 04.2020 / PubMed / Full text
Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells. / 11.2019 / PubMed / Full text
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth. / 01.05.2019 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
Preclinical characterization of abemaciclib in hormone receptor positive breast cancer. / 19.09.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma. / 03.2017 / PubMed / Full text
p16INK4a suppresses BRCA1-deficient mammary tumorigenesis. / 20.12.2016 / PubMed / Full text
A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. / 27.09.2016 / PubMed / Full text
CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response. / 02.10.2016 / PubMed / Full text
Sperm-associated antigen 9 (SPAG9) promotes the survival and tumor growth of triple-negative breast cancer cells. / 10.2016 / PubMed / Full text
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6. / 13.05.2016 / PubMed / Full text
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. / 07.2014 / PubMed / Full text
Sporadic colorectal cancer development shows rejuvenescence regarding epithelial proliferation and apoptosis. / 2013 / PubMed / Full text

CXCL12[править]

Identification of genes associated with endometrial cell aging. / 01.12.2020 / PubMed / Full text
Co-option of Neutrophil Fates by Tissue Environments. / 25.11.2020 / PubMed / Full text
Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels. / 15.12.2020 / PubMed / Full text
The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells. / 29.07.2020 / PubMed / Full text
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. / 05.02.2020 / PubMed / Full text
Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation. / 03.12.2019 / PubMed / Full text
Recent Advances in Mono- and Combined Stem Cell Therapies of Stroke in Animal Models and Humans. / 29.11.2019 / PubMed / Full text
Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation. / 12.2019 / PubMed / Full text
Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging. / 2018 / PubMed / Full text
Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy. / 28.06.2018 / PubMed / Full text
Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. / 07.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats. / 06.2017 / PubMed / Full text
Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by Omeprazole and Lansoprazole treatment. / 04.2017 / PubMed / Full text
The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. / 03.2017 / PubMed / Full text
Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. / 02.11.2015 / PubMed / Full text
[The expression of differential and matrix remodelling factors in human buccal epithelium in aging]. / 2013 / PubMed
Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo. / 04.02.2014 / PubMed / Full text

MPO[править]

Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis. / 15.10.2020 / PubMed / Full text
Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis. / 01.2020 / PubMed / Full text
Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk? / 08.07.2019 / PubMed / Full text
Local and systemic effects of aging on acute pancreatitis. / 07.2019 / PubMed / Full text
Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty "cytokinome" at its core. / 15.07.2019 / PubMed / Full text
Astaxanthin-Rich [i]Haematococcus pluvialis[/i] Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2. / 08.2018 / PubMed / Full text
Effect of β-D-Mannuronic Acid (M2000) on Oxidative Stress Enzymes' Gene Using Healthy Donor Peripheral Blood Mononuclear Cells for Evaluating the Anti-Aging Property. / 2019 / PubMed / Full text
Chlorinative stress in age-related diseases: a literature review. / 2017 / PubMed / Full text
Hippocampal-dependent memory deficit induced by perinatal exposure to polutted eels in middle-aged offspring mice: Sex differential effects. / 05.10.2017 / PubMed / Full text
Effect of g.9476869G>A myeloperoxidase (MPO) gene polymorphism on the antioxidant activity of milk from Polish Holstein-Friesian cows of the Black-and-White variety (HO). / 05.2017 / PubMed / Full text
An in vitro evaluation of anti-aging effect of guluronic acid (G2013) based on enzymatic oxidative stress gene expression using healthy individuals PBMCs. / 06.2017 / PubMed / Full text
Age-determined severity of anti-myeloperoxidase autoantibody-mediated glomerulonephritis in mice. / 01.02.2017 / PubMed / Full text
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type. / 04.2017 / PubMed / Full text
Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving β-catenin signaling in hyperlipidemia. / 27.11.2015 / PubMed / Full text
Genetic Deletion of Prostacyclin IP Receptor Exacerbates Transient Global Cerebral Ischemia in Aging Mice. / 22.07.2013 / PubMed / Full text
Redox regulation of protein damage in plasma. / 2014 / PubMed / Full text
Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population - the Hoorn Study. / 02.2014 / PubMed / Full text
Activation profile of CXCL8-stimulated neutrophils and aging. / 03.2013 / PubMed / Full text

RET[править]

The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. / 11.2020 / PubMed / Full text
Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis. / 09.2020 / PubMed / Full text
Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial. / 09.2020 / PubMed / Full text
Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. / 01.04.2020 / PubMed / Full text
Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. / 11.2019 / PubMed / Full text
Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease. / 2019 / PubMed / Full text
Physical, Chemical, Microstructural and Rheological Properties of Reactive Terpolymer-Modified Bitumen. / 20.03.2019 / PubMed / Full text
Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue. / 2015 / PubMed / Full text
Manganese-mediated acceleration of age-related hearing loss in mice. / 08.11.2016 / PubMed / Full text
Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans. / 15.12.2016 / PubMed / Full text
Resistance exercise training and in vitro skeletal muscle oxidative capacity in older adults. / 07.2016 / PubMed / Full text
Determination phase at transition of gonocytes to spermatogonial stem cells improves establishment efficiency of spermatogonial stem cells in domestic cats. / 2015 / PubMed / Full text
GDNF and GFRα co-receptor family in the developing feline gut. / 09.2014 / PubMed / Full text
Long-term prognosis of patients with pediatric pheochromocytoma. / 02.2014 / PubMed / Full text
Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. / 09.2013 / PubMed / Full text
Molecular networks of human muscle adaptation to exercise and age. / 03.2013 / PubMed / Full text
Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats. / 04.2013 / PubMed / Full text
Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium. / 03.2013 / PubMed / Full text

RUNX2[править]

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture. / 08.2020 / PubMed / Full text
Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. / 05.2020 / PubMed / Full text
Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis. / 02.2020 / PubMed / Full text
Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation. / 09.2019 / PubMed
Collaboration of MYC and RUNX2 in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity. / 10.2019 / PubMed / Full text
Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. / 09.2019 / PubMed / Full text
microRNA-31 inhibition partially ameliorates the deficiency of bone marrow stromal cells from cleidocranial dysplasia. / 06.2019 / PubMed / Full text
Betaine promotes cell differentiation of human osteoblasts in primary culture. / 07.06.2017 / PubMed / Full text
Effects of the donor age on proliferation, senescence and osteogenic capacity of human urine-derived stem cells. / 10.2017 / PubMed / Full text
Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells. / 23.02.2017 / PubMed / Full text
Influence of Donor Age and Stimulation Intensity on Osteogenic Differentiation of Rat Mesenchymal Stromal Cells in Response to Focused Low-Intensity Pulsed Ultrasound. / 12.2016 / PubMed / Full text
Aging impairs osteoblast differentiation of mesenchymal stem cells grown on titanium by favoring adipogenesis. / 07-08.2016 / PubMed / Full text
Deficiency in the anti-aging gene Klotho promotes aortic valve fibrosis through AMPKα-mediated activation of RUNX2. / 10.2016 / PubMed / Full text
The induction of cellular senescence in dental follicle cells inhibits the osteogenic differentiation. / 06.2016 / PubMed / Full text
The effects of strength training and raloxifene on bone health in aging ovariectomized rats. / 04.2016 / PubMed / Full text
Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes. / 12.2014 / PubMed / Full text
The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism. / 2014 / PubMed / Full text
Chronic low dose tumor necrosis factor-α (TNF) suppresses early bone accrual in young mice by inhibiting osteoblasts without affecting osteoclasts. / 09.2013 / PubMed / Full text

BRCA2[править]

BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. / 01.01.2020 / PubMed / Full text
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. / 25.11.2019 / PubMed / Full text
Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts. / 12.2019 / PubMed / Full text
Klotho gene polymorphisms are associated with healthy aging and longevity: Evidence from a meta-analysis. / 03.2019 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
Faulty BRCA1, BRCA2 genes: how poor is the prognosis? / 10.2017 / PubMed / Full text
Ovarian Aging in Women With BRCA Germline Mutations. / 01.10.2017 / PubMed / Full text
The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy. / 01.2018 / PubMed / Full text
A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer. / 04.2017 / PubMed / Full text
Serum AMH levels in healthy women from BRCA1/2 mutated families: are they reduced? / 11.2016 / PubMed / Full text
Paradoxical delay of senescence upon depletion of BRCA2 in telomerase-deficient worms. / 10.2016 / PubMed / Full text
Women's preferences for contralateral prophylactic mastectomy: An investigation using protection motivation theory. / 05.2016 / PubMed / Full text
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. / 19.10.2015 / PubMed / Full text
BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. / 09.2015 / PubMed / Full text
[Role of DNA repair genes in radiation-induced changes of lifespan of Drosophila melanogaster]. / 09-10.2014 / PubMed
Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients. / 09.2013 / PubMed / Full text
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. / 13.02.2013 / PubMed / Full text

CA4[править]

Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome. / 06.2020 / PubMed / Full text
One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging. / 2019 / PubMed / Full text
Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype. / 2019 / PubMed / Full text
Dissociable age and memory relationships with hippocampal subfield volumes in vivo:Data from the Irish Longitudinal Study on Ageing (TILDA). / 29.07.2019 / PubMed / Full text
Aerobic exercise increases hippocampal subfield volumes in younger adults and prevents volume decline in the elderly. / 10.2020 / PubMed / Full text
The Volume of Hippocampal Subfields in Relation to Decline of Memory Recall Across the Adult Lifespan. / 2018 / PubMed / Full text
Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. / 2018 / PubMed / Full text
Age-related changes in cortical and subcortical structures of healthy adult brains: A surface-based morphometry study. / 01.2019 / PubMed / Full text
Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population. / 07.2018 / PubMed / Full text
Protective effect of a phenolic extract containing indoline amides from Portulaca oleracea against cognitive impairment in senescent mice induced by large dose of D-galactose /NaNO . / 05.05.2017 / PubMed / Full text
Roles of hippocampal subfields in verbal and visual episodic memory. / 15.01.2017 / PubMed / Full text
Bayesian longitudinal segmentation of hippocampal substructures in brain MRI using subject-specific atlases. / 01.11.2016 / PubMed / Full text
Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects. / 09.2016 / PubMed / Full text
Pathological changes in hippocampal neuronal circuits underlie age-associated neurodegeneration and memory loss: positive clue toward SAD. / 20.08.2015 / PubMed / Full text
Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly. / 09.2015 / PubMed / Full text
Neuron volumes in hippocampal subfields in delayed poststroke and aging-related dementias. / 04.2014 / PubMed / Full text
Regional vulnerability of hippocampal subfields to aging measured by structural and diffusion MRI. / 04.2014 / PubMed / Full text

CCL11[править]

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders. / 02.09.2020 / PubMed / Full text
Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. / 11.2019 / PubMed / Full text
Young bone marrow transplantation preserves learning and memory in old mice. / 2019 / PubMed / Full text
[The role of «Youth and aging proteins» in essential hypertension pathogenesis.] / 2018 / PubMed
Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers. / 11.2018 / PubMed / Full text
Inflammaging impairs peripheral nerve maintenance and regeneration. / 12.2018 / PubMed / Full text
Stem Cell-Induced Pulp Regeneration Can Be Enhanced by Administration of CCL11-Neutralizing Antibody in the Ectopic Tooth Transplantation Model in the Aged Mice. / 02.2019 / PubMed / Full text
Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy. / 01.02.2018 / PubMed / Full text
["Protein of senility" CCL11, "protein of juvenility" GDF11 and their role in age-related pathology]. / 2016 / PubMed
Telomere Length and CCL11 Levels are Associated With Gray Matter Volume and Episodic Memory Performance in Schizophrenia: Evidence of Pathological Accelerated Aging. / 13.01.2018 / PubMed / Full text
An emerging role for eotaxins in neurodegenerative disease. / 04.2018 / PubMed / Full text
Blood-Borne Revitalization of the Aged Brain. / 10.2015 / PubMed / Full text
[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data]. / 2014 / PubMed
Rejuvenation: it's in our blood. / 01.07.2014 / PubMed / Full text
Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. / 11.2014 / PubMed / Full text
Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers. / 01.10.2013 / PubMed / Full text
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. / 05.02.2013 / PubMed / Full text

CFTR[править]

Exercise Physiology Across the Lifespan in Cystic Fibrosis. / 2019 / PubMed / Full text
Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice. / 02.09.2019 / PubMed / Full text
Is cellular senescence involved in cystic fibrosis? / 14.02.2019 / PubMed / Full text
Autophagy delays progression of the two most frequent human monogenetic lethal diseases: cystic fibrosis and Wilson disease. / 19.12.2018 / PubMed / Full text
The Clinical Biology of Cystic Fibrosis Transmembrane Regulator Protein: Its Role and Function in Extrapulmonary Disease. / 03.2019 / PubMed / Full text
[Ageing with cystic fibrosis: Classical and emerging comorbidities in adults with cystic fibrosis]. / 10.2018 / PubMed / Full text
A review of inflammatory mechanism in airway diseases. / 01.2019 / PubMed / Full text
Up-to-date and projected estimates of survival for people with cystic fibrosis using baseline characteristics: A longitudinal study using UK patient registry data. / 03.2018 / PubMed / Full text
New treatments targeting the basic defects in cystic fibrosis. / 06.2017 / PubMed / Full text
[Pancreatic infringement exocrine and endocrine in cystic fibrosis]. / 12.2016 / PubMed / Full text
Molecular modeling in the age of clinical genomics, the enterprise of the next generation. / 03.2017 / PubMed / Full text
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. / 04.08.2016 / PubMed / Full text
The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice. / 12.2015 / PubMed / Full text
Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. / 08.2015 / PubMed / Full text
Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. / 05.2014 / PubMed / Full text
Decreased expression of cystic fibrosis transmembrane conductance regulator impairs sperm quality in aged men. / 12.2013 / PubMed / Full text
Cystic fibrosis transmembrane conductance regulator is correlated closely with sperm progressive motility and normal morphology in healthy and fertile men with normal sperm parameters. / 10.2014 / PubMed / Full text

FH[править]

Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. / 2020 / PubMed / Full text
Genetic risk of dementia modifies obesity effects on white matter myelin in cognitively healthy adults. / 10.2020 / PubMed / Full text
Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. / 07.2020 / PubMed / Full text
Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. / 02.2020 / PubMed / Full text
LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. / 2020 / PubMed / Full text
Sex differences in cholesterol levels from birth to 19 years of age may lead to increased cholesterol burden in females with FH. / 05-06.2018 / PubMed / Full text
Association between lipoprotein (a) and proprotein convertase substilisin/kexin type 9 in patients with heterozygous familial hypercholesterolemia: A case-control study. / 02.2018 / PubMed / Full text
Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer's Disease. / 09.2017 / PubMed / Full text
Diffusion Tensor Imaging Predictors of Episodic Memory Decline in Healthy Elders at Genetic Risk for Alzheimer's Disease. / 11.2016 / PubMed / Full text
Familial hypercholesterolaemia reduces the quality of life of patients not reaching treatment targets. / 05.2016 / PubMed
Effect of fetal hypothyroidism on tolerance to ischemia-reperfusion injury in aged male rats: Role of nitric oxide. / 01.05.2016 / PubMed / Full text
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. / 21.09.2015 / PubMed / Full text
Impact of family history of alcoholism on glutamine/glutamate ratio in anterior cingulate cortex in substance-naïve adolescents. / 12.2015 / PubMed / Full text
Age-Based Differences in the Genetic Determinants of Glycemic Control: A Case of FOXO3 Variations. / 2015 / PubMed / Full text
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. / 04.2014 / PubMed / Full text
Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design - HOME Study report number 1. / 03.2014 / PubMed / Full text
Mild clinical presentation and prolonged survival of a patient with fumarase deficiency due to the combination of a known and a novel mutation in FH gene. / 25.07.2013 / PubMed / Full text

G6PD[править]

G6PD overexpression protects from oxidative stress and age-related hearing loss. / 22.11.2020 / PubMed / Full text
The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability. / 12.08.2020 / PubMed / Full text
FSHR ablation induces depression-like behaviors. / 08.2020 / PubMed / Full text
DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice. / 01.2020 / PubMed / Full text
JNK modifies neuronal metabolism to promote proteostasis and longevity. / 06.2019 / PubMed / Full text
Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats. / 12.2017 / PubMed / Full text
Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53. / 11.2018 / PubMed / Full text
Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial. / 28.03.2018 / PubMed / Full text
Effect of age, period and birth-cohort on the frequency of glucose-6-phosphate dehydrogenase deficiency in Sardinian adults. / 02.2018 / PubMed / Full text
Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling. / 2017 / PubMed / Full text
G6PD protects from oxidative damage and improves healthspan in mice. / 15.03.2016 / PubMed / Full text
Age-dependent detection of erythrocytes glucose-6-phosphate dehydrogenase and its correlation with oxidative stress. / 2016 / PubMed / Full text
Overexpression of hsp27 Rescued Neuronal Cell Death and Reduction in Life- and Health-Span in Drosophila melanogaster Against Prolonged Exposure to Dichlorvos. / 07.2016 / PubMed / Full text
Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion. / 01.2015 / PubMed / Full text
Short-term calorie restriction and refeeding differently affect lipogenic enzymes in major white adipose tissue depots of young and old rats. / 02.2014 / PubMed
Brain glucose-6-phosphate dehydrogenase protects against endogenous oxidative DNA damage and neurodegeneration in aged mice. / 17.07.2013 / PubMed / Full text
Involvement of redox state in the aging of Drosophila melanogaster. / 10.09.2013 / PubMed / Full text

GAL[править]

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis. / 02.2020 / PubMed / Full text
β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice. / 05.2020 / PubMed / Full text
Senescence-associated β-galactosidase activity in the developing avian retina. / 09.2019 / PubMed / Full text
Zeaxanthin Isolated from [i]Dunaliella salina[/i] Microalgae Ameliorates Age Associated Cardiac Dysfunction in Rats through Stimulation of Retinoid Receptors. / 14.05.2019 / PubMed / Full text
Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway. / 15.07.2019 / PubMed / Full text
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts. / 2018 / PubMed / Full text
Manipulation of molecular pathways and senescence hallmarks by natural compounds in fibroblast cells. / 04.2019 / PubMed / Full text
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study. / 12.2018 / PubMed / Full text
Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging. / 04.2018 / PubMed / Full text
Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production. / 12.2017 / PubMed / Full text
Carnosine Treatment Diminished Oxidative Stress and Glycation Products in Serum and Tissues of D-Galactose-Treated Rats. / 2018 / PubMed / Full text
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study. / 03.2016 / PubMed / Full text
Carnosine and taurine treatments diminished brain oxidative stress and apoptosis in D-galactose aging model. / 04.2016 / PubMed / Full text
Five years of interdisciplinary research on ageing and technology: Outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL)--an introduction to this Special Issue on Ageing and Technology. / 09-12.2014 / PubMed / Full text
Information and communication technologies for promoting and sustaining quality of life, health and self-sufficiency in ageing societies--outcomes of the Lower Saxony Research Network Design of Environments for Ageing (GAL). / 09-12.2014 / PubMed / Full text
Cyanidin-3-O-galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice. / 03.2014 / PubMed / Full text
Blueberry treatment attenuates D-galactose-induced oxidative stress and tissue damage in rat liver. / 04.2014 / PubMed / Full text

HDAC1[править]

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. / 18.05.2020 / PubMed / Full text
Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart. / 04.2019 / PubMed / Full text
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies. / 20.10.2018 / PubMed / Full text
Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. / 16.05.2019 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. / 06.2018 / PubMed / Full text
Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment. / 30.05.2017 / PubMed / Full text
Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. / 10.2017 / PubMed / Full text
Emerging roles for histone deacetylases in age-related muscle atrophy. / 27.10.2016 / PubMed / Full text
[i]Rpd3[/i] interacts with insulin signaling in [i]Drosophila[/i] longevity extension. / 14.11.2016 / PubMed / Full text
Expression of non-secreted IL-4 is associated with HDAC inhibitor-induced cell death, histone acetylation and c-Jun regulation in human gamma/delta T-cells. / 04.10.2016 / PubMed / Full text
The effects of Rpd3 on fly metabolism, health, and longevity. / 15.12.2016 / PubMed / Full text
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. / 23.02.2016 / PubMed / Full text
Scopoletin has a potential activity for anti-aging via autophagy in human lung fibroblasts. / 15.03.2015 / PubMed / Full text
De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins. / 2015 / PubMed / Full text
Lysine deacetylases regulate the heat shock response including the age-associated impairment of HSF1. / 10.04.2015 / PubMed / Full text
Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. / 02.2014 / PubMed / Full text

HSF1[править]

Cellular proteostasis decline in human senescence. / 30.11.2020 / PubMed / Full text
A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse. / 28.09.2020 / PubMed / Full text
Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. / 18.10.2019 / PubMed / Full text
Multifactorial Attenuation of the Murine Heat Shock Response With Age. / 25.09.2020 / PubMed / Full text
Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). / 04.2019 / PubMed / Full text
CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans. / 10.2018 / PubMed / Full text
Modulation of Heat Shock Factor 1 Activity through Silencing of Ser303/Ser307 Phosphorylation Supports a Metabolic Program Leading to Age-Related Obesity and Insulin Resistance. / 15.09.2018 / PubMed / Full text
The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer. / 20.06.2018 / PubMed / Full text
Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. / 08.05.2018 / PubMed / Full text
Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease. / 08.2018 / PubMed / Full text
Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging. / 12.2016 / PubMed / Full text
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. / 15.06.2016 / PubMed / Full text
Determinants of rodent longevity in the chaperone-protein degradation network. / 05.2016 / PubMed / Full text
SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. / 29.08.2014 / PubMed / Full text
Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders. / 15.07.2014 / PubMed / Full text
Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process. / 2014 / PubMed / Full text
Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast. / 12.2013 / PubMed / Full text

IGF1R[править]

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice. / 10.2020 / PubMed / Full text
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. / 2019 / PubMed / Full text
Integration of Biochemical, Cellular, and Genetic Indicators for Understanding the Aging Process in a Bivalve Mollusk Chlamys farreri. / 10.2019 / PubMed / Full text
In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated. / 13.04.2019 / PubMed / Full text
Insulin/IGF-1 signaling and aging. / 09.2016 / PubMed
Effect of young exosomes injected in aged mice. / 2018 / PubMed / Full text
The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions. / 06.2018 / PubMed / Full text
The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons. / 01.07.2017 / PubMed / Full text
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. / 04.04.2017 / PubMed / Full text
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Nongenomic effects via the mineralocorticoid receptor. / 07.2017 / PubMed / Full text
A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). / 07.11.2016 / PubMed / Full text
Differential Regulation of Hippocampal IGF-1-Associated Signaling Proteins by Dietary Restriction in Aging Mouse. / 08.2017 / PubMed / Full text
Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts. / 09.2016 / PubMed / Full text
Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. / 23.02.2016 / PubMed / Full text
Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. / 01.2016 / PubMed / Full text
The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets. / 05.05.2015 / PubMed / Full text
Clinical significance of proliferation, apoptosis and senescence of nasopharyngeal cells by the simultaneously blocking EGF, IGF-1 receptors and Bcl-xl genes. / 01.11.2013 / PubMed / Full text

IRS1[править]

17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines. / 15.07.2020 / PubMed / Full text
MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle. / 06.2020 / PubMed / Full text
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. / 2019 / PubMed / Full text
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. / 01.2020 / PubMed / Full text
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD. / 17.08.2019 / PubMed / Full text
Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. / 08.2019 / PubMed / Full text
The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells. / 06.2019 / PubMed / Full text
Fucoidan⁻Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3β/CREB Pathways and Metabolic Pathways in Senescent Mice. / 21.01.2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. / 20.05.2018 / PubMed / Full text
Small nucleoli are a cellular hallmark of longevity. / 30.08.2017 / PubMed / Full text
An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8. / 01.12.2017 / PubMed / Full text
Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction. / 06.09.2016 / PubMed / Full text
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. / 02.2016 / PubMed / Full text
Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle. / 12.2015 / PubMed / Full text
Effect of growth hormone receptor gene disruption and PMA treatment on the expression of genes involved in primordial follicle activation in mice ovaries. / 2014 / PubMed / Full text
Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice. / 02.2014 / PubMed / Full text

KLRG1[править]

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial. / 18.10.2020 / PubMed / Full text
T Lymphocytes in Patients With Nijmegen Breakage Syndrome Demonstrate Features of Exhaustion and Senescence in Flow Cytometric Evaluation of Maturation Pathway. / 2020 / PubMed / Full text
Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients. / 05.2020 / PubMed / Full text
Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis. / 04.2020 / PubMed / Full text
Are skin senescence and immunosenescence linked within individuals? / 08.2019 / PubMed / Full text
Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients. / 09.2018 / PubMed / Full text
Impact of Aging on the Frequency, Phenotype, and Function of CD161-Expressing T Cells. / 2018 / PubMed / Full text
Lifelong training improves anti-inflammatory environment and maintains the number of regulatory T cells in masters athletes. / 06.2017 / PubMed / Full text
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells. / 2016 / PubMed / Full text
KLRG1 restricts memory T cell antitumor immunity. / 20.09.2016 / PubMed / Full text
PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit. / 05.2016 / PubMed / Full text
Immunosenescence of the CD8( ) T cell compartment is associated with HIV-infection, but only weakly reflects age-related processes of adipose tissue, metabolism, and muscle in antiretroviral therapy-treated HIV-infected patients and controls. / 26.11.2015 / PubMed / Full text
The Effects of Age and Latent Cytomegalovirus Infection on NK-Cell Phenotype and Exercise Responsiveness in Man. / 2015 / PubMed / Full text
Control of CD8 T cell proliferation and terminal differentiation by active STAT5 and CDKN2A/CDKN2B. / 08.2015 / PubMed / Full text
KLRG1 impairs CD4 T cell responses via p16ink4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection. / 15.01.2014 / PubMed / Full text
The effects of age and latent cytomegalovirus infection on the redeployment of CD8 T cell subsets in response to acute exercise in humans. / 07.2014 / PubMed / Full text
Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. / 06.2013 / PubMed / Full text

MMP1[править]

Does Type II Diabetes Induce Early Senescence and Degeneration in Human Intervertebral Discs? A Tissue Biomarker Evaluation. / 06.2020 / PubMed / Full text
Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts. / 12.2020 / PubMed / Full text
Secretome of Senescent Adipose-Derived Mesenchymal Stem Cells Negatively Regulates Angiogenesis. / 05.03.2020 / PubMed / Full text
The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). / 01.05.2020 / PubMed / Full text
Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors. / 26.11.2019 / PubMed / Full text
A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes. / 06.2020 / PubMed / Full text
Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy. / 2019 / PubMed / Full text
Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease. / 05.2019 / PubMed / Full text
Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix-related gene expression partly via secretion of complement factor D. / 07.2019 / PubMed / Full text
Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A. / 12.03.2019 / PubMed / Full text
Retinoic acid promotes in vitro follicle activation in the cat ovary by regulating expression of matrix metalloproteinase 9. / 2018 / PubMed / Full text
[Changes of the expression for genes related with senescence and the telomerase activity during cellular replicative and premature senescence in human embryonic lung fibroblasts]. / 20.01.2017 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging. / 2015 / PubMed / Full text
Anti-photoaging potential of Botulinum Toxin Type A in UVB-induced premature senescence of human dermal fibroblasts in vitro through decreasing senescence-related proteins. / 05.04.2014 / PubMed / Full text
A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes. / 01.2015 / PubMed / Full text
Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats. / 02.2014 / PubMed / Full text

NANOG[править]

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture. / 08.2020 / PubMed / Full text
Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes. / 11.2019 / PubMed / Full text
Restoring extracellular matrix synthesis in senescent stem cells. / 10.2019 / PubMed / Full text
Maternal ageing impairs mitochondrial DNA kinetics during early embryogenesis in mice. / 08.07.2019 / PubMed / Full text
Amnion epithelial cell-derived exosomes induce inflammatory changes in uterine cells. / 11.2018 / PubMed / Full text
NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings. / 01.2018 / PubMed / Full text
Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features. / 02.01.2018 / PubMed / Full text
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. / 01.09.2017 / PubMed / Full text
Low Dose of Doxorubicin Potentiates the Effect of Temozolomide in Glioblastoma Cells. / 05.2018 / PubMed / Full text
NANOG Restores Contractility of Mesenchymal Stem Cell-Based Senescent Microtissues. / 06.2017 / PubMed / Full text
Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. / 07.02.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
NANOG Reverses the Myogenic Differentiation Potential of Senescent Stem Cells by Restoring ACTIN Filamentous Organization and SRF-Dependent Gene Expression. / 01.2017 / PubMed / Full text
Disentangling the aneuploidy and senescence paradoxes: a study of triploid breast cancers non-responsive to neoadjuvant therapy. / 04.2016 / PubMed / Full text
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. / 2015 / PubMed / Full text
Molecular differences between stromal cell populations from deciduous and permanent human teeth. / 18.04.2015 / PubMed / Full text
Critical role of the miR-200 family in regulating differentiation and proliferation of neurons. / 06.2015 / PubMed / Full text

OGG1[править]

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice. / 20.11.2020 / PubMed / Full text
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. / 18.05.2020 / PubMed / Full text
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle. / 27.11.2019 / PubMed / Full text
8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes. / 09.2019 / PubMed / Full text
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. / 01.05.2019 / PubMed / Full text
[Protective effect of Wuzi Yanzong recipe on testicular DNA oxidative damage in natural ageing rats]. / 07.2018 / PubMed / Full text
The replicative senescent mesenchymal stem / stromal cells defect in DNA damage response and anti-oxidative capacity. / 2018 / PubMed / Full text
DNA damage and telomere length shortening in the peripheral blood leukocytes of 20 years SM-exposed veterans. / 08.2018 / PubMed / Full text
"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content. / 01.12.2016 / PubMed / Full text
8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging. / 01.2017 / PubMed / Full text
Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus - an aging connection. / 04.2016 / PubMed / Full text
[The polymorphism of DNA repair genes XPD, XRCC1, OGG1, and ERCC6, life expectancy, and the inclination to smoke]. / 08.2014 / PubMed
Altered DNA Methylation and Expression Profiles of 8-Oxoguanine DNA Glycosylase 1 in Lens Tissue from Age-related Cataract Patients. / 2015 / PubMed / Full text
Polymorphisms of DNA repair genes OGG1 and XPD and the risk of age-related cataract in Egyptians. / 2014 / PubMed / Full text
Postprandial activation of p53-dependent DNA repair is modified by Mediterranean diet supplemented with coenzyme Q10 in elderly subjects. / 07.2014 / PubMed / Full text
The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line. / 09.2013 / PubMed / Full text
Age-dependent guanine oxidation in DNA of different brain regions of Wistar rats and prematurely aging OXYS rats. / 06.2013 / PubMed / Full text

OPA1[править]

[i]Sirt3[/i] Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by [i]Opa1[/i] Gene Transfer. / 12.2019 / PubMed / Full text
Novel role of the SIRT4-OPA1 axis in mitochondrial quality control. / 23.12.2017 / PubMed / Full text
Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles. / 15.06.2019 / PubMed / Full text
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice. / 2018 / PubMed / Full text
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. / 29.10.2017 / PubMed / Full text
Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria. / 11.2017 / PubMed / Full text
Dietary supplementation with acetyl-l-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats. / 11.2017 / PubMed / Full text
Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging. / 10.2017 / PubMed / Full text
Effects of β-hydroxy-β-methylbutyrate on skeletal muscle mitochondrial content and dynamics, and lipids after 10 days of bed rest in older adults. / 01.11.2017 / PubMed / Full text
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. / 06.06.2017 / PubMed / Full text
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. / 04.2017 / PubMed / Full text
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics. / 12.2016 / PubMed / Full text
Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity. / 03.2017 / PubMed / Full text
'Mitotherapy' for Heart Failure. / 04.2016 / PubMed / Full text
Genotype-phenotype heterogeneity of ganglion cell and inner plexiform layer deficit in autosomal-dominant optic atrophy. / 12.2015 / PubMed / Full text
Ontogeny of muscle bioenergetics in Adelie penguin chicks (Pygoscelis adeliae). / 01.11.2013 / PubMed / Full text
N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress. / 04.02.2013 / PubMed / Full text

SOX9[править]

Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation. / 06.2020 / PubMed / Full text
Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice. / 07.2020 / PubMed / Full text
Epigenetic Mechanisms Underlying the Aging of Articular Cartilage and Osteoarthritis. / 2019 / PubMed / Full text
Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence. / 26.06.2018 / PubMed / Full text
Role of CD133 Molecule in Wnt Response and Renal Repair. / 03.2018 / PubMed / Full text
Age-related modulation of angiogenesis-regulating factors in the swine meniscus. / 11.2017 / PubMed / Full text
SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. / 26.04.2017 / PubMed / Full text
Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes. / 15.03.2017 / PubMed / Full text
Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage. / 03.2017 / PubMed / Full text
RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration. / 09.2017 / PubMed / Full text
Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes. / 06.2016 / PubMed / Full text
mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance. / 2016 / PubMed / Full text
Dynamic epigenetic mechanisms regulate age-dependent SOX9 expression in mouse articular cartilage. / 03.2016 / PubMed / Full text
FOXA1 and SOX9 Expression in the Developing Urogenital Sinus of the Tammar Wallaby (Macropus eugenii). / 2015 / PubMed / Full text
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration. / 02.2016 / PubMed / Full text
Fractures in geriatric mice show decreased callus expansion and bone volume. / 11.2014 / PubMed / Full text
Age-dependent decrease in the chondrogenic potential of human bone marrow mesenchymal stromal cells expanded with fibroblast growth factor-2. / 09.2013 / PubMed / Full text

AKT1[править]

Autophagy drives fibroblast senescence through MTORC2 regulation. / 11.2020 / PubMed / Full text
Proteomics of Long-Lived Mammals. / 03.2020 / PubMed / Full text
MicroRNA-495 enhances chondrocyte apoptosis, senescence and promotes the progression of osteoarthritis by targeting AKT1. / 2019 / PubMed / Full text
Therapeutic and preventive effects of exercise on cardiometabolic parameters in aging and obese rats. / 02.2019 / PubMed / Full text
The biological age linked to oxidative stress modifies breast cancer aggressiveness. / 20.05.2018 / PubMed / Full text
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. / 05.01.2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
Cinnamaldehyde and eugenol change the expression folds of AKT1 and DKC1 genes and decrease the telomere length of human adipose-derived stem cells (hASCs): An experimental and in silico study. / 03.2017 / PubMed / Full text
Expression profile analysis of new candidate genes for the therapy of primary osteoporosis. / 2016 / PubMed
CBX8 antagonizes the effect of Sirtinol on premature senescence through the AKT-RB-E2F1 pathway in K562 leukemia cells. / 22.01.2016 / PubMed / Full text
Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population. / 05.01.2016 / PubMed / Full text
[SOME RESULTS OF MOLECULAR GENETIC RESEARCHES OF AGING AND LONGEVITY]. / 2015 / PubMed
Coordinated Expression of Phosphoinositide Metabolic Genes during Development and Aging of Human Dorsolateral Prefrontal Cortex. / 2015 / PubMed / Full text
Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy. / 27.10.2014 / PubMed / Full text
Age and space irradiation modulate tumor progression: implications for carcinogenesis risk. / 02.2013 / PubMed / Full text

ATG7[править]

Age-related impairment of autophagy in cervical motor neurons. / 05.12.2020 / PubMed / Full text
Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts. / 09.06.2020 / PubMed / Full text
Regulation of autophagy by DNA G-quadruplexes. / 18.05.2020 / PubMed / Full text
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. / 10.2020 / PubMed / Full text
Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts. / 2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy. / 2018 / PubMed / Full text
Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line. / 2018 / PubMed / Full text
SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. / 09.2017 / PubMed / Full text
Epigallocatechin-3-gallate increases autophagy signaling in resting and unloaded plantaris muscles but selectively suppresses autophagy protein abundance in reloaded muscles of aged rats. / 06.2017 / PubMed / Full text
Autophagic homeostasis is required for the pluripotency of cancer stem cells. / 02.2017 / PubMed / Full text
Characterization of an Autophagy-Related Gene MdATG8i from Apple. / 2016 / PubMed / Full text
Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress. / 05.04.2016 / PubMed / Full text
Measuring In Vivo Mitophagy. / 19.11.2015 / PubMed / Full text
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification. / 05.2014 / PubMed / Full text
Autophagic response to exercise training in skeletal muscle with age. / 12.2013 / PubMed / Full text

CD5[править]

Comparative proteomic analysis identifies biomarkers for renal aging. / 06.11.2020 / PubMed / Full text
Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy. / 2019 / PubMed / Full text
Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell Stages for B1a Cell Generation. / 2019 / PubMed / Full text
Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells. / 04.2019 / PubMed / Full text
Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice. / 15.07.2018 / PubMed / Full text
Age-related changes in mRNA expression of selected surface receptors in lymphocytes of dairy calves. / 03.2018 / PubMed / Full text
Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses. / 17.08.2017 / PubMed / Full text
Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response. / 08.2017 / PubMed / Full text
Alterations in the Thymic Selection Threshold Skew the Self-Reactivity of the TCR Repertoire in Neonates. / 01.08.2017 / PubMed / Full text
Developmental expression of B cell molecules in equine lymphoid tissues. / 01.2017 / PubMed / Full text
[Molecular Mechanisms of Functional Activity Decreasing of the Skin Cells With Its Aging]. / 04-06.2016 / PubMed
Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging. / 15.03.2016 / PubMed / Full text
Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8 T cells in aged mice. / 02.02.2016 / PubMed / Full text
[POLYPEPTIDES INFLUENCE ON TISSUE CELL CULTURES REGENERATION OF VARIOUS AGE RATS]. / 2015 / PubMed
Self-recognition drives the preferential accumulation of promiscuous CD4( ) T-cells in aged mice. / 14.07.2015 / PubMed / Full text
Chemotherapy-induced changes and immunosenescence of CD8 T-cells in patients with breast cancer. / 03.2015 / PubMed

CETP[править]

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study. / 2018 / PubMed / Full text
THE ENDOCRINOLOGY OF AGING: A KEY TO LONGEVITY "GREAT EXPECTATIONS". / 09.2017 / PubMed / Full text
Mathematically modelling the dynamics of cholesterol metabolism and ageing. / 07.2016 / PubMed / Full text
No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. / 06.2016 / PubMed / Full text
Anti-Aging and Tissue Regeneration Ability of Policosanol Along with Lipid-Lowering Effect in Hyperlipidemic Zebrafish via Enhancement of High-Density Lipoprotein Functionality. / 04.2016 / PubMed / Full text
Enhancement of High-Density Lipoprotein Cholesterol Functions by Encapsulation of Policosanol Exerts Anti-Senescence and Tissue Regeneration Effects Via Improvement of Anti-Glycation, Anti-Apoptosis, and Cholesteryl Ester Transfer Inhibition. / 02.2016 / PubMed / Full text
Reference values for high-density lipoprotein particle size and volume by dynamic light scattering in a Brazilian population sample and their relationships with metabolic parameters. / 10.03.2015 / PubMed / Full text
Serum amyloid A-related inflammation is lowered by increased fruit and vegetable intake, while high-sensitive C-reactive protein, IL-6 and E-selectin remain unresponsive. / 14.10.2014 / PubMed / Full text
Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure. / 11.2014 / PubMed / Full text
Genetic analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol. / 2014 / PubMed / Full text
Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women. / 07.2014 / PubMed / Full text
[Clinical and genetic characteristics of long-livers in Moscow region]. / 2013 / PubMed
Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy. / 06.2014 / PubMed / Full text
Association study of promoter polymorphisms in the CETP gene with longevity in the Han Chinese population. / 01.2014 / PubMed / Full text
Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis. / 2013 / PubMed / Full text
The frequency of 4 common gene polymorphisms in nonagenarians, centenarians, and average life span individuals. / 03.2014 / PubMed / Full text

CFH[править]

The expression of C1 inhibitor (C1INH) in macrophages is upregulated by retinal pigment epithelial cells - implication in subretinal immune privilege in the aging eye. / 13.06.2018 / PubMed / Full text
Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. / 05.2017 / PubMed / Full text
Benefits, Potential Harms, and Optimal Use of Nutritional Supplementation for Preventing Progression of Age-Related Macular Degeneration. / 03.2017 / PubMed / Full text
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging. / 14.07.2016 / PubMed / Full text
Mesopic Pelli-Robson contrast sensitivity and MP-1 microperimetry in healthy ageing and age-related macular degeneration. / 12.2016 / PubMed / Full text
[Age-related Macular Degeneration in the Japanese]. / 03.2016 / PubMed
Genetic factors associated with the development of age-related macular degeneration. / 2016 / PubMed / Full text
Prevalence and Genetic Characteristics of Geographic Atrophy among Elderly Japanese with Age-Related Macular Degeneration. / 2016 / PubMed / Full text
The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning. / 11.2014 / PubMed / Full text
Age-dependent changes in heparan sulfate in human Bruch's membrane: implications for age-related macular degeneration. / 29.07.2014 / PubMed / Full text
Death by color: differential cone loss in the aging mouse retina. / 11.2014 / PubMed / Full text
Complement factor H and related proteins in age-related macular degeneration. / 03.2014 / PubMed / Full text
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration. / 11.2013 / PubMed / Full text
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. / 11.2013 / PubMed / Full text
[The relationship between the polymorphism of immunity genes and both aging and age-related diseases]. / 07.2013 / PubMed / Full text
Retinal changes precede visual dysfunction in the complement factor H knockout mouse. / 2013 / PubMed / Full text

CLOCK[править]

Circadian rhythm disruption and Alzheimer's disease: The dynamics of a vicious cycle. / 28.04.2020 / PubMed / Full text
Investigating circadian clock gene expression in human tendon biopsies from acute exercise and immobilization studies. / 06.2019 / PubMed / Full text
CLOCK gene polymorphisms and quality of aging in a cohort of nonagenarians - The MUGELLO Study. / 06.02.2019 / PubMed / Full text
Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women. / 21.11.2018 / PubMed / Full text
Aging and chromatoid body assembly: Are these two physiological events linked? / 07.2018 / PubMed / Full text
CIRCADIAN CLOCK-ASSOCIATED 1 Inhibits Leaf Senescence in [i]Arabidopsis[/i]. / 2018 / PubMed / Full text
Circadian clocks: from stem cells to tissue homeostasis and regeneration. / 01.2018 / PubMed / Full text
Female ClockΔ19/Δ19 mice are protected from the development of age-dependent cardiomyopathy. / 01.02.2018 / PubMed / Full text
Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population. / 11.04.2017 / PubMed / Full text
Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease. / 04.2017 / PubMed / Full text
Circadian deep sequencing reveals stress-response genes that adopt robust rhythmic expression during aging. / 21.02.2017 / PubMed / Full text
The circadian rhythm controls telomeres and telomerase activity. / 29.08.2014 / PubMed / Full text
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. / 12.2013 / PubMed / Full text
SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging. / 20.06.2013 / PubMed / Full text
Long-lasting effect of perinatal exposure to L-tryptophan on circadian clock of primary cell lines established from male offspring born from mothers fed on dietary protein restriction. / 2013 / PubMed / Full text
Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly. / 01.03.2013 / PubMed / Full text

FGF2[править]

Myokines: The endocrine coupling of skeletal muscle and bone. / 2020 / PubMed / Full text
The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture. / 04.2020 / PubMed / Full text
Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing. / 15.10.2019 / PubMed / Full text
Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. / 08.2019 / PubMed / Full text
Evaluation of human mesenchymal stem cell senescence, differentiation and secretion behavior cultured on polycarbonate cell culture inserts. / 2018 / PubMed / Full text
Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2. / 12.2018 / PubMed / Full text
Skin-resident stem cells and wound healing. / 2017 / PubMed / Full text
Regulation of skeletal muscle stem cells by fibroblast growth factors. / 05.2017 / PubMed / Full text
Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life. / 07.2017 / PubMed / Full text
Decline in Proliferation and Immature Neuron Markers in the Human Subependymal Zone during Aging: Relationship to EGF- and FGF-Related Transcripts. / 2016 / PubMed / Full text
Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. / 05.2017 / PubMed / Full text
Novel Protein Arginine Methyltransferase 8 Isoform Is Essential for Cell Proliferation. / 09.2016 / PubMed / Full text
Apoptosis during embryonic tissue remodeling is accompanied by cell senescence. / 11.2015 / PubMed / Full text
Age-specific functional epigenetic changes in p21 and p16 in injury-activated satellite cells. / 03.2015 / PubMed / Full text
Female aging alters expression of human cumulus cells genes that are essential for oocyte quality. / 2014 / PubMed / Full text
Prostatic microenvironment in senescence: fibroblastic growth factors × hormonal imbalance. / 05.2014 / PubMed / Full text

FOXO4[править]

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. / 03.04.2020 / PubMed / Full text
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. / 20.01.2020 / PubMed / Full text
KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21. / 01.03.2020 / PubMed / Full text
Introduction to FOXO Biology. / 2019 / PubMed / Full text
Regulation of cellular senescence via the FOXO4-p53 axis. / 06.2018 / PubMed / Full text
Cellular senescence in the aging and diseased kidney. / 03.2018 / PubMed / Full text
[Molecular regulative mechanisms of aging and interventional effects of Chinese herbal medicine]. / 08.2017 / PubMed / Full text
FOXO Transcriptional Factors and Long-Term Living. / 2017 / PubMed / Full text
Reduction in podocyte SIRT1 accelerates kidney injury in aging mice. / 01.09.2017 / PubMed / Full text
Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration. / 12.2017 / PubMed / Full text
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. / 23.03.2017 / PubMed / Full text
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. / 01.02.2016 / PubMed / Full text
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. / 04.2016 / PubMed / Full text
Cleaved high molecular weight kininogen stimulates JNK/FOXO4/MnSOD pathway for induction of endothelial progenitor cell senescence. / 08.08.2014 / PubMed / Full text
Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. / 01.2014 / PubMed / Full text
FOXO4 is necessary for neural differentiation of human embryonic stem cells. / 06.2013 / PubMed / Full text

GRN[править]

Stressful development: Integrating endoderm development, stress, and longevity. / 08.12.2020 / PubMed / Full text
Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. / 05.08.2020 / PubMed / Full text
A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program. / 04.11.2019 / PubMed / Full text
Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice. / 2018 / PubMed / Full text
Combined Pathologies in FTLD-TDP Types A and C. / 01.05.2018 / PubMed / Full text
A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. / 04.2018 / PubMed / Full text
Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging Phenotypes. / 26.04.2017 / PubMed / Full text
CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. / 04.2017 / PubMed / Full text
Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. / 05.2017 / PubMed / Full text
Data file of a deep proteome analysis of the prefrontal cortex in aged mice with progranulin deficiency or neuronal overexpression of progranulin. / 12.2016 / PubMed / Full text
Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study. / 26.07.2016 / PubMed / Full text
Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test. / 07.2016 / PubMed / Full text
Hippocampal Sclerosis of Aging, a Common Alzheimer's Disease 'Mimic': Risk Genotypes are Associated with Brain Atrophy Outside the Temporal Lobe. / 2016 / PubMed / Full text
Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis. / 24.02.2016 / PubMed / Full text
Differential clinicopathologic and genetic features of late-onset amnestic dementias. / 09.2014 / PubMed / Full text
Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers. / 05.2013 / PubMed / Full text

HDAC3[править]

Histone deacetylase-3: Friend and foe of the brain. / 07.2020 / PubMed / Full text
Loss of HDAC3 contributes to meiotic defects in aged oocytes. / 12.2019 / PubMed / Full text
HDAC3-Mediated Repression of the [i]Nr4a[/i] Family Contributes to Age-Related Impairments in Long-Term Memory. / 19.06.2019 / PubMed / Full text
Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke. / 04.2019 / PubMed / Full text
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State. / 04.12.2018 / PubMed / Full text
Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway. / 12.2018 / PubMed / Full text
Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. / 20.08.2018 / PubMed / Full text
Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri. / 09.2018 / PubMed / Full text
Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. / 10.2017 / PubMed / Full text
Emerging roles for histone deacetylases in age-related muscle atrophy. / 27.10.2016 / PubMed / Full text
Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B. / 18.11.2015 / PubMed / Full text
Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells. / 01.2016 / PubMed / Full text
Non-sirtuin histone deacetylases in the control of cardiac aging. / 06.2015 / PubMed / Full text
HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels. / 16.09.2014 / PubMed / Full text
Deleted in Breast Cancer 1 regulates cellular senescence during obesity. / 10.2014 / PubMed / Full text
Prenatal ethanol exposure causes glucose intolerance with increased hepatic gluconeogenesis and histone deacetylases in adult rat offspring: reversal by tauroursodeoxycholic acid. / 2013 / PubMed / Full text

IGFBP3[править]

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients. / 05.2020 / PubMed / Full text
Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes. / 15.01.2020 / PubMed / Full text
Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. / 17.01.2020 / PubMed / Full text
Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? / 2019 / PubMed / Full text
Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age. / 10.2018 / PubMed / Full text
Systemic analysis of gene expression profiles in porcine granulosa cells during aging. / 14.11.2017 / PubMed / Full text
G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. / 15.11.2017 / PubMed / Full text
A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence. / 08.11.2016 / PubMed / Full text
Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity. / 12.2016 / PubMed / Full text
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. / 10.2016 / PubMed / Full text
Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses. / 07.2016 / PubMed / Full text
Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway. / 12.2015 / PubMed / Full text
Reference values of IGF1, IGFBP3 and IGF1/IGFBP3 ratio in adult population in the Czech Republic. / 15.04.2015 / PubMed / Full text
Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults. / 02.2014 / PubMed / Full text
Reduced expression level of the cyclic adenosine monophosphate response element-binding protein contributes to lung aging. / 01.2014 / PubMed / Full text
Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state. / 11.2013 / PubMed / Full text

MPI[править]

Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study. / 05.2020 / PubMed / Full text
Interest of the multidimensional prognostic index (MPI) as an assessment tool in hospitalized patients in geriatrics. / 01.12.2019 / PubMed / Full text
Reducing Potentially Inappropriate Medications in Older Adults: A Way Forward. / 12.2019 / PubMed / Full text
The prognostic significance of geriatric syndromes and resources. / 01.2020 / PubMed / Full text
[Polypharmacy and associated factors in elderly diabetic]. / 05-06.2018 / PubMed / Full text
An examination of the concordance between self-reported collisions, driver records, and insurance claims in older drivers. / 12.2018 / PubMed / Full text
Age Modifies the Association of Dietary Protein Intake with All-Cause Mortality in Patients with Chronic Kidney Disease. / 13.11.2018 / PubMed / Full text
New associations of the Multidimensional Prognostic Index. / 08.2019 / PubMed / Full text
Effects of oral amino acid supplementation on Multidimensional Prognostic Index in hospitalized older patients: a multicenter randomized, double-blind, placebo-controlled pilot study. / 2018 / PubMed / Full text
Degree of Peripheral Thyroxin Deiodination, Frailty, and Long-Term Survival in Hospitalized Older Patients. / 01.05.2018 / PubMed / Full text
Age-Related Difference in Functional Brain Connectivity of Mastication. / 2017 / PubMed / Full text
Warfarin Treatment and All-Cause Mortality in Community-Dwelling Older Adults with Atrial Fibrillation: A Retrospective Observational Study. / 07.2016 / PubMed / Full text
Change in the Multidimensional Prognostic Index Score During Hospitalization in Older Patients. / 06.2016 / PubMed / Full text
Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors. / 09.2016 / PubMed / Full text
Immune senescence and cancer in elderly patients: results from an exploratory study. / 12.2013 / PubMed / Full text
Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients. / 06.2013 / PubMed / Full text

S100B[править]

Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. / 12.2020 / PubMed / Full text
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. / 12.03.2020 / PubMed / Full text
The Role of S100B in Aerobic Training Efficacy in Older Adults with Mild Vascular Cognitive Impairment: Secondary Analysis of a Randomized Controlled Trial. / 01.07.2019 / PubMed / Full text
Changes in mechanoreceptors in rabbits' anterior cruciate ligaments with age. / 06.2019 / PubMed / Full text
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases. / 11.2018 / PubMed / Full text
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex. / 25.07.2018 / PubMed / Full text
Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat. / 01.10.2018 / PubMed / Full text
Improving the clinical management of traumatic brain injury through the pharmacokinetic modeling of peripheral blood biomarkers. / 30.11.2016 / PubMed / Full text
Sex-Specific Effects of Prenatal Stress on Memory and Markers of Neuronal Activity in Juvenile Rats. / 2016 / PubMed / Full text
Specific age-related molecular alterations in the cerebellum of Down syndrome mouse models. / 01.09.2016 / PubMed / Full text
Age-dependent increase of blood-brain barrier permeability and neuron-binding autoantibodies in S100B knockout mice. / 15.04.2016 / PubMed / Full text
Influence of Age on Cerebral Housekeeping Gene Expression for Normalization of Quantitative Polymerase Chain Reaction after Acute Brain Injury in Mice. / 15.11.2015 / PubMed / Full text
Amyloid-β immunotherapy reduces amyloid plaques and astroglial reaction in aged domestic dogs. / 2015 / PubMed / Full text
Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE. / 12.2013 / PubMed / Full text
Serum S100B represents a new biomarker for mood disorders. / 10.2013 / PubMed / Full text
Intraperitoneal treatment with S100B enhances hippocampal neurogenesis in juvenile mice and after experimental brain injury. / 07.2013 / PubMed / Full text

TRPV1[править]

Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. / 02.2020 / PubMed / Full text
Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. / 01.11.2018 / PubMed / Full text
Expression of CGRP neurotransmitter and vascular genesis marker mRNA is age-dependent in superior cervical ganglia of senescence-accelerated prone mice. / 18.01.2018 / PubMed / Full text
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases. / 02.2018 / PubMed / Full text
Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. / 01.07.2017 / PubMed / Full text
Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin. / 2017 / PubMed / Full text
Differential Adulthood Onset mGlu5 Signaling Saves Prefrontal Function in the Fragile X Mouse. / 01.12.2017 / PubMed / Full text
TRPV1 deletion exacerbates hyperthermic seizures in an age-dependent manner in mice. / 12.2016 / PubMed / Full text
TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration. / 08.2016 / PubMed / Full text
The Protective Role of Selenium on Scopolamine-Induced Memory Impairment, Oxidative Stress, and Apoptosis in Aged Rats: The Involvement of TRPM2 and TRPV1 Channels. / 05.2017 / PubMed / Full text
Ageing and gastrointestinal sensory function: altered colonic mechanosensory and chemosensory function in the aged mouse. / 15.08.2016 / PubMed / Full text
Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. / 08.2015 / PubMed / Full text
Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels. / 22.01.2015 / PubMed / Full text
Age-dependent sensitization of cutaneous nociceptors during developmental inflammation. / 07.06.2014 / PubMed / Full text
Die another day: a painless path to longevity. / 22.05.2014 / PubMed / Full text
TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. / 22.05.2014 / PubMed / Full text

TTR[править]

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration. / 04.2020 / PubMed / Full text
Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening. / 14.12.2018 / PubMed / Full text
Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis. / 02.2018 / PubMed / Full text
The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice. / 04.2018 / PubMed / Full text
Transthyretin deposition promotes progression of osteoarthritis. / 12.2017 / PubMed / Full text
Assessment of Oral Anticoagulant Use in Residents of Long-Term Care Homes: Evidence for Contemporary Suboptimal Use. / 12.2017 / PubMed / Full text
Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid. / 2016 / PubMed / Full text
Recipient aging accelerates acquired transthyretin amyloidosis after domino liver transplantation. / 05.2016 / PubMed / Full text
Plasma concentrations of transthyretin in older Sardinians including centenarians. / 02.2016 / PubMed / Full text
Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments. / 09.2015 / PubMed / Full text
Impact of short periods with worsened or improved INR control on life expectancy and QALYs in patients with atrial fibrillation. / 06.2014 / PubMed / Full text
Physiological IgM class catalytic antibodies selective for transthyretin amyloid. / 09.05.2014 / PubMed / Full text
HuR and other turnover- and translation-regulatory RNA-binding proteins: implications for the kidney. / 15.03.2014 / PubMed / Full text
Effect of age and sex differences on wild-type transthyretin amyloid formation in familial amyloidotic polyneuropathy: a proteomic approach. / 05.12.2013 / PubMed / Full text
Use of vitamin K antagonist therapy in geriatrics: a French national survey from the French Society of Geriatrics and Gerontology (SFGG). / 12.2013 / PubMed / Full text
Age-related oxidative modifications of transthyretin modulate its amyloidogenicity. / 19.03.2013 / PubMed / Full text

AHR[править]

Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging. / 01.09.2020 / PubMed / Full text
Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis. / 28.11.2019 / PubMed / Full text
Loss of Neurogenesis in Aging Hydra. / 05.2019 / PubMed / Full text
Environmental cues received during development shape dendritic cell responses later in life. / 2018 / PubMed / Full text
Nursing Home Use After Implantable Cardioverter-Defibrillator Implantation in Older Adults: Results from the National Cardiovascular Data Registry. / 02.2017 / PubMed / Full text
Genetic variants associated with skin aging in the Chinese Han population. / 04.2017 / PubMed / Full text
Smoking and Obesity Increase Airway Hyperesponsiveness Risk in the Elderly. / 2016 / PubMed / Full text
Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice. / 2015 / PubMed / Full text
Enhanced allergic airway disease in old mice is associated with a Th17 response. / 10.2014 / PubMed / Full text
Influenza A infection enhances antigen-induced airway inflammation and hyperresponsiveness in young but not aged mice. / 09.2014 / PubMed / Full text
A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. / 08.2014 / PubMed / Full text
Early postnatal, but not late, exposure to chemical ambient pollutant 1,2-naphthoquinone increases susceptibility to pulmonary allergic inflammation at adulthood. / 08.2014 / PubMed / Full text
Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. / 21.10.2013 / PubMed / Full text
Ventilation heterogeneity is associated with airway responsiveness in asthma but not COPD. / 01.10.2013 / PubMed / Full text
Relationship between airway pathophysiology and airway inflammation in older asthmatics. / 10.2013 / PubMed / Full text

C5[править]

The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care. / 23.06.2020 / PubMed / Full text
Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma? / 26.06.2020 / PubMed / Full text
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population. / 2018 / PubMed / Full text
Longevity of adenovirus vector immunity in mice and its implications for vaccine efficacy. / 29.10.2018 / PubMed / Full text
Generating Rasch-based activity of daily living measures from the Spinal Cord Injury Longitudinal Aging Study. / 01.2018 / PubMed / Full text
A Large Cohort Study of 18F Fluoro-Deoxy-Glucose Uptake in Normal Spinal Cord: Quantitative Assessment of the Contamination From Adjacent Vertebral Marrow Uptake and Validity of Normalizing the Cord Uptake Against the Lumbar Thecal Sac. / 01.2017 / PubMed / Full text
Demographic aspects in cervical vertebral bodies' size and shape (C3-C7): a skeletal study. / 01.2017 / PubMed / Full text
Tract-specific and age-related variations of the spinal cord microstructure: a multi-parametric MRI study using diffusion tensor imaging (DTI) and inhomogeneous magnetization transfer (ihMT). / 06.2016 / PubMed / Full text
Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease. / 03.2017 / PubMed / Full text
The incidence of cervical spondylosis decreases with aging in the elderly, and increases with aging in the young and adult population: a hospital-based clinical analysis. / 2016 / PubMed / Full text
Signal intensity loss of the intervertebral discs in the cervical spine of young patients on fluid sensitive sequences. / 03.2016 / PubMed / Full text
Are the standard parameters of cervical spine alignment and range of motion related to age, sex, and cervical disc degeneration? / 09.2015 / PubMed / Full text
DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease. / 2015 / PubMed / Full text
Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid. / 29.11.2013 / PubMed / Full text
Developmental biomechanics of the human cervical spine. / 05.04.2013 / PubMed / Full text

CCS[править]

Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study. / 01.12.2020 / PubMed / Full text
Premature Ocular Aging Features in Childhood Acute Lymphoblastic Leukemia Survivors. / 30.09.2020 / PubMed / Full text
Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study. / 2020 / PubMed / Full text
Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects. / 2019 / PubMed / Full text
Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging. / 2019 / PubMed / Full text
Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly. / 01.2020 / PubMed / Full text
Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. / 01.2020 / PubMed / Full text
Cardiovascular Risk Assessment and Follow-Up of Women After Hypertensive Disorders of Pregnancy:A Prospective Cohort Study. / 08.2019 / PubMed / Full text
T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors. / 06.11.2018 / PubMed / Full text
Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study. / 09.2018 / PubMed / Full text
High risk of hypogonadism in young male cancer survivors. / 03.2018 / PubMed / Full text
Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts. / 11-12.2015 / PubMed / Full text
[Changes in light sensitivity of the visual system with age and in patients with ischemic optic neuropathy]. / 2015 / PubMed / Full text
Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study. / 20.12.2013 / PubMed / Full text
Endocrine health conditions in adult survivors of childhood cancer: the need for specialized adult-focused follow-up clinics. / 03.2013 / PubMed / Full text

CD69[править]

CD8 HLADR Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function. / 2018 / PubMed / Full text
Differential Impact of Obesity on CD69 Expression in Individuals with Bipolar Disorder and Healthy Controls. / 05.2018 / PubMed / Full text
An immunological age index in bipolar disorder: A confirmatory factor analysis of putative immunosenescence markers and associations with clinical characteristics. / 12.2018 / PubMed / Full text
Differences Between Pediatric and Adult T Cell Responses to [i]In Vitro[/i] Staphylococcal Enterotoxin B Stimulation. / 2018 / PubMed / Full text
Associations between immunological function and memory recall in healthy adults. / 12.2017 / PubMed / Full text
Varicella-Zoster Virus-Specific Cellular Immune Responses to the Live Attenuated Zoster Vaccine in Young and Older Adults. / 15.07.2017 / PubMed / Full text
Natural killer cell recognition of [i]in vivo[/i] drug-induced senescent multiple myeloma cells. / 2016 / PubMed / Full text
IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. / 01.08.2015 / PubMed / Full text
Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation. / 01.08.2015 / PubMed / Full text
CD4⁺CD28null T lymphocytes resemble CD8⁺CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients. / 09.2015 / PubMed / Full text
Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B. / 06.2015 / PubMed / Full text
Dysfunction of dendritic cells in aged C57BL/6 mice leads to failure of natural killer cell activation and of tumor eradication. / 30.09.2014 / PubMed / Full text
The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 CXCR5 T follicular helper cells: comparison of aged and young subjects. / 2014 / PubMed / Full text
Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy. / 08.2013 / PubMed / Full text
Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses. / 06.2013 / PubMed / Full text

CD80[править]

The aging common marmoset's immune system: From junior to senior. / 06.2020 / PubMed / Full text
[i]Akkermansia muciniphila[/i] ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging [i]Ercc1[/i] mice. / 2019 / PubMed / Full text
The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy. / 2018 / PubMed / Full text
Age-related M1/M2 phenotype changes in circulating monocytes from healthy/unhealthy individuals. / 08.06.2018 / PubMed / Full text
Elderly dendritic cells respond to LPS/IFN-γ and CD40L stimulation despite incomplete maturation. / 2018 / PubMed / Full text
Immunosenescence Induced by Plasma from Individuals with Obesity Caused Cell Signaling Dysfunction and Inflammation. / 09.2017 / PubMed / Full text
Melatonin: Antioxidant and modulatory properties in age-related changes during Trypanosoma cruzi infection. / 08.2017 / PubMed / Full text
Aged B cells alter immune regulation of allografts in mice. / 11.2016 / PubMed / Full text
Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes. / 02.2016 / PubMed / Full text
Expression of HLA-DR, CD80, and CD86 in Healthy Aging and Alzheimer's Disease. / 2015 / PubMed / Full text
17β-Estradiol influences in vitro response of aged rat splenic conventional dendritic cells to TLR4 and TLR7/8 agonists in an agonist specific manner. / 01.2015 / PubMed / Full text
Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection. / 2014 / PubMed / Full text
Changes in the expression of the Toll-like receptor system in the aging rat kidneys. / 2014 / PubMed / Full text
Probiotic modulation of dendritic cell function is influenced by ageing. / 02.2014 / PubMed / Full text
An age-related numerical and functional deficit in CD19( ) CD24(hi) CD38(hi) B cells is associated with an increase in systemic autoimmunity. / 10.2013 / PubMed / Full text

ERCC1[править]

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis. / 2020 / PubMed / Full text
Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging. / 30.06.2020 / PubMed / Full text
Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. / 17.04.2020 / PubMed / Full text
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. / 03.2020 / PubMed / Full text
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. / 03.2020 / PubMed / Full text
Aerobic exercise promotes the expression of ERCC1 to prolong lifespan: A new possible mechanism. / 01.2019 / PubMed / Full text
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. / 09.2018 / PubMed / Full text
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. / 20.08.2018 / PubMed / Full text
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. / 07.2018 / PubMed / Full text
Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. / 09.07.2018 / PubMed / Full text
The age-related expression decline of ERCC1 and XPF for forensic age estimation: A preliminary study. / 07.2017 / PubMed / Full text
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging. / 07.2017 / PubMed / Full text
Phosphodiesterase 1 regulation is a key mechanism in vascular aging. / 12.2015 / PubMed / Full text
Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. / 10.2014 / PubMed / Full text
Polymorphisms in ERCC1 C8092A predict progression-free survival in metastatic/recurrent nasopharyngeal carcinoma treated with cisplatin-based chemotherapy. / 08.2013 / PubMed / Full text

FHL2[править]

Age prediction in living: Forensic epigenetic age estimation based on blood samples. / 11.2020 / PubMed / Full text
Age Estimation Based on DNA Methylation Using Blood Samples From Deceased Individuals. / 03.2020 / PubMed / Full text
Genetic associations with age of menopause in familial longevity. / 10.2019 / PubMed / Full text
DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples. / 01.2019 / PubMed / Full text
DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups. / 01.2018 / PubMed / Full text
Independent validation of DNA-based approaches for age prediction in blood. / 07.2017 / PubMed / Full text
Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. / 12.05.2017 / PubMed / Full text
Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process. / 01.08.2017 / PubMed / Full text
Donor age and C1orf132/MIR29B2C determine age-related methylation signature of blood after allogeneic hematopoietic stem cell transplantation. / 2016 / PubMed / Full text
Forensic age prediction for dead or living samples by use of methylation-sensitive high resolution melting. / 07.2016 / PubMed / Full text
Identification of common and differential mechanisms of glomerulus and tubule senescence in 24-month-old rats by quantitative LC-MS/MS. / 10.2016 / PubMed / Full text
Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system. / 09.2016 / PubMed / Full text
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. / 09.02.2016 / PubMed / Full text
Development of a forensically useful age prediction method based on DNA methylation analysis. / 07.2015 / PubMed / Full text
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. / 06.2014 / PubMed / Full text

GATA4[править]

Epigenetics and Vascular Senescence-Potential New Therapeutic Targets? / 2020 / PubMed / Full text
Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype. / 25.08.2020 / PubMed / Full text
ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. / 06.07.2020 / PubMed / Full text
Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. / 01.2020 / PubMed / Full text
NF-κB signaling in skin aging. / 12.2019 / PubMed / Full text
The zinc finger protein GATA4 induces mesenchymal-to-epithelial transition and cellular senescence through the nuclear factor-κB pathway in hepatocellular carcinoma. / 12.2019 / PubMed / Full text
Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart. / 07.01.2019 / PubMed / Full text
GATA Regulation and Function During the Ovarian Life Cycle. / 2018 / PubMed / Full text
Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. / 01.10.2017 / PubMed / Full text
Decline in cellular function of aged mouse c-kit cardiac progenitor cells. / 01.10.2017 / PubMed / Full text
DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age. / 08.2017 / PubMed / Full text
Epigallocatechin gallate reverses cTnI-low expression-induced age-related heart diastolic dysfunction through histone acetylation modification. / 10.2017 / PubMed / Full text
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. / 25.09.2015 / PubMed / Full text
Ageing is a risk factor in imatinib mesylate cardiotoxicity. / 04.2014 / PubMed / Full text
Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy. / 03.2013 / PubMed / Full text

HTT[править]

Biological Aging and the Cellular Pathogenesis of Huntington's Disease. / 2020 / PubMed / Full text
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. / 2018 / PubMed / Full text
Early Neurodegeneration in R6/2 Mice Carrying the Huntington's Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan. / 2018 / PubMed / Full text
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. / 03.2018 / PubMed / Full text
Cell-to-cell Transmission of Polyglutamine Aggregates in [i]C. elegans[/i]. / 12.2017 / PubMed / Full text
Proteostasis of Huntingtin in Health and Disease. / 19.07.2017 / PubMed / Full text
Bar-coding neurodegeneration: identifying subcellular effects of human neurodegenerative disease proteins using [i]Drosophila[/i] leg neurons. / 01.08.2017 / PubMed / Full text
Age-associated chromatin relaxation is enhanced in Huntington's disease mice. / 12.03.2017 / PubMed / Full text
Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. / 22.03.2016 / PubMed / Full text
Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. / 31.07.2015 / PubMed / Full text
Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life. / 05.2015 / PubMed / Full text
Epidemiology of Huntington disease: first post-HTT gene analysis of prevalence in Italy. / 03.2016 / PubMed / Full text
Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function. / 10.09.2014 / PubMed / Full text
Serotonin transporter polymorphism is associated with increased apnea-hypopnea index in older adults. / 03.2014 / PubMed / Full text
Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. / 07.2013 / PubMed / Full text

INS[править]

[Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence]. / 03.2020 / PubMed / Full text
Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. / 03.07.2020 / PubMed / Full text
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. / 08.2020 / PubMed / Full text
Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. / 05.2020 / PubMed / Full text
Insulin-like peptides and the mTOR-TFEB pathway protect [i]Caenorhabditis elegans[/i] hermaphrodites from mating-induced death. / 08.07.2019 / PubMed / Full text
The Maghreb demographic transition: Tunisia case study. / 10-11.2018 / PubMed
Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis. / 02.2019 / PubMed / Full text
A functional study of all 40 [i]Caenorhabditis elegans[/i] insulin-like peptides. / 26.10.2018 / PubMed / Full text
The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells. / 02.12.2017 / PubMed / Full text
Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice. / 2016 / PubMed / Full text
Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides. / 01.05.2016 / PubMed / Full text
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. / 2016 / PubMed
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Aging genes 10-19

C6[править]

CD19[править]

ECD[править]

KLF4[править]

MTR[править]

UCP2[править]

ALDH2[править]

CCR7[править]

CD86[править]

CDK2[править]

CDK6[править]

CXCL12[править]

MPO[править]

RET[править]

RUNX2[править]

BRCA2[править]

CA4[править]

CCL11[править]

CFTR[править]

FH[править]

G6PD[править]

GAL[править]

HDAC1[править]

HSF1[править]

IGF1R[править]

IRS1[править]

KLRG1[править]

MMP1[править]

NANOG[править]

OGG1[править]

OPA1[править]

SOX9[править]

AKT1[править]

ATG7[править]

CD5[править]

CETP[править]

CFH[править]

CLOCK[править]

FGF2[править]

FOXO4[править]

GRN[править]

HDAC3[править]

IGFBP3[править]

MPI[править]

S100B[править]

TRPV1[править]

TTR[править]

AHR[править]

C5[править]

CCS[править]

CD69[править]

CD80[править]

ERCC1[править]

FHL2[править]

GATA4[править]

HTT[править]

INS[править]

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