Публикации о генах и старении (titles): различия между версиями

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(не показано 13 промежуточных версий этого же участника)
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==Diet-derived fruit and vegetable metabolites show sex-specific inverse relationships to osteoporosis status.==
===Abstract===
The impact of nutrition on the metabolic profile of osteoporosis (OS) is unknown. Identify biochemical factors driving the association of fruit and vegetable (FV) intakes with OS prevalence using an untargeted metabolomics approach. Cross-sectional dietary, anthropometric and plasma metabolite data were examined from the Boston Puerto Rican Osteoporosis Study, n = 600 (46-79 yr). Bone mineral density was assessed by DXA. OS was defined by clinical standards. A culturally adapted FFQ assessed usual dietary intake. Principal components analysis (PCA) of 42 FV items created 6 factors. Metabolomic profiles derived from plasma samples were assessed on a commercial platform. Differences in levels of 525 plasma metabolites between disease groups (OS vs no-OS) were compared using logistic regression; and associations with FV intakes by multivariable linear regression, adjusted for covariates. Metabolites significantly associated with OS status or with total FV intake were analyzed for enrichment in various biological pathways using Mbrole 2.0, MetaboAnalyst, and Reactome, using FDR correction of P-values. Correlation coefficients were calculated as Spearman's rho rank correlations, followed by hierarchical clustering of the resulting correlation coefficients using PCA FV factors and sex-specific sets of OS-associated metabolites. High FV intake was inversely related to OS prevalence (Odds Ratio = 0.73; 95% CI = 0.57, 0.94; P = 0.01). Several biological processes affiliated with the FV-associating metabolites, including caffeine metabolism, carnitines and fatty acids, and glycerophospholipids. Important processes identified with OS-associated metabolites were steroid hormone biosynthesis in women and branched-chain amino acid metabolism in men. Factors derived from PCA were correlated with the OS-associated metabolites, with high intake of dark leafy greens and berries/melons appearing protective in both sexes. These data warrant investigation into whether increasing intakes of dark leafy greens, berries and melons causally affect bone turnover and BMD among middle-aged and older adults at risk for osteoporosis via sex-specific metabolic pathways, and how gene-diet interactions alter these sex-specific metabolomic-osteoporosis links.


===MeSH Terms===
==A2M==
-


===Keywords===
{{medline-entry
Aging; Metabolism; Metabolomics; Nutrition; Osteoporosis; Puerto Rican; Sex steroids
|title=Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31489526


==A case of comorbidities highlighting cerebral stroke, vision impairment, and dementia.==
|mesh-terms=* Adult
===Abstract===
* Aging
This case report is of a two-time stroke survivor with significant health comorbidities. This report highlights A.R.'s pre-existing, non-neurological vision impairments, stroke-related vision impairments, in addition to cognitive impairment and possible dementia. Information including her past medical history, current functional status, and battery of assessments that were used in the acute care hospital are detailed. Conclusions include the need for comprehensive, valid, and adapted assessments especially when comorbidities are present. We suggest that cognitive assessments that do not rely on vision may have improved the test accuracy in this case.
* Electrophoresis, Gel, Two-Dimensional
* Glycosylation
* Humans
* Infant, Newborn
* Polysaccharides
* Pregnancy-Associated alpha 2-Macroglobulins
* Protein Isoforms
* Umbilical Cord
|keywords=* Alpha-2-macroglobulin
* Glycosylation
* Newborn
* Plasma
|full-text-url=https://sci-hub.do/10.1007/s12013-019-00883-4
}}
==AACS==


===MeSH Terms===
{{medline-entry
-
|title=Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33170149


===Keywords===
Visual impairment; aging; comorbidities; dementia; neuro-ophthalmology; stroke


==Whole blood DNA methylation aging markers predict colorectal cancer survival: a prospective cohort study.==
|keywords=* aging
===Abstract===
* longitudinal studies
Blood DNA methylation-based aging algorithms predict mortality in the general population. We investigated the prognostic value of five established DNA methylation aging algorithms for patients with colorectal cancer (CRC). AgeAccelHorvath, AgeAccelHannum, DNAmMRscore, AgeAccelPheno and AgeAccelGrim were constructed using whole blood epi-genomic data from 2206 CRC patients. After a median follow-up of 6.2 years, 1079 deaths were documented, including 596 from CRC. Associations of the aging algorithms with survival outcomes were evaluated using the Cox regression and survival curves. Harrell's C-statistics were computed to investigate predictive performance. Adjusted hazard ratios (95% confidence intervals) of all-cause mortality for patients in the third compared to the first tertile were 1.66 (1.32, 2.09) for the DNAmMRscore, 1.35 (1.14, 1.59) for AgeAccelPheno and 1.65 (1.37, 2.00) for AgeAccelGrim, even after adjustment for age, sex and stage. AgeAccelHorvath and AgeAccelHannum were not associated with all-cause or CRC-specific mortality. In stage-specific analyses, associations were much stronger for patients with early or intermediate stage cancers (stages I, II and III) than for patients with metastatic (stage IV) cancers. Associations were weaker and less often statistically significant for CRC-specific mortality. Adding DNAmMRscore, AgeAccelPheno or AgeAccelGrim to models including age, sex and tumor stage improved predictive performance moderately. DNAmMRscore, AgeAccelPheno and AgeAccelGrim could serve as non-invasive CRC prognostic biomarkers independent of other commonly used markers. Further research should aim for tailoring and refining such algorithms for CRC patients and to explore their value for enhanced prediction of treatment success and treatment decisions.
* normative
* self-report
* sex characteristics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695390
}}
==ABCG2==


===MeSH Terms===
{{medline-entry
-
|title=Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285109


===Keywords===
Aging; Colorectal cancer; DNA methylation; Mortality; Prognosis; Whole blood


==Coordination in the unfolded protein response during aging in outbred deer mice.==
|keywords=* cellular senescence
===Abstract===
* embryo receptivity
Endoplasmic reticulum (ER) stress has been linked to various metabolic pathologies, neurodegeneration and aging. Although various mechanistic aspects of the resulting unfolded protein response (UPR) have been elucidated, its regulation in genetically diverse populations remains elusive. In the present study we evaluated the expression of chaperones BiP/GRP78, GRP94 and calnexin (CANX) in the lungs, liver and brain of 7 months old and 2-3 years old outbred deer mice P. maniculatus and P. leucopus. Chaperones' expression was highly variable between species, tissues and ages suggesting that levels of expression of individual chaperones do not change consistently during aging. Despite this variation, a high degree of coordination was maintained between chaperones' expression indicating the tight regulation of the UPR which is consistent with its adaptive activity to maintain homeostasis. In the brain though of older P. maniculatus, at which neurodegenerative changes were detected, loss of coordination was revealed, especially between BiP and either of GRP94 or calnexin which indicates that de-coordination rather than aberrant expression is linked to deregulation of the UPR in aging. These findings underscore the involvement of UPR in the onset of aging-related pathologies and suggest that beyond levels of expression, concerted activation may be of significance to attain homeostasis. These findings emphasize the value of genetically diverse models and suggest that beyond levels of expression of individual targets the coordination of transcriptional networks should be considered when links to pathology are explored.
* endometrial stem cell
* human endometrial stromal cell
* infertility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313258
}}
{{medline-entry
|title=[[ABCG2]] rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32183743


===MeSH Terms===
|mesh-terms=* ATP Binding Cassette Transporter, Subfamily G, Member 2
-
* Aged
* Aged, 80 and over
* Aging
* Cardiovascular Diseases
* China
* Cohort Studies
* Effect Modifier, Epidemiologic
* Epistasis, Genetic
* Female
* Genes, Modifier
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Glucose Transport Proteins, Facilitative
* Humans
* Hyperuricemia
* Independent Living
* Male
* Neoplasm Proteins
* Organic Anion Transporters
* Organic Cation Transport Proteins
* Polymorphism, Single Nucleotide
* Risk Factors
* Uric Acid
|keywords=* ABCG2
* Hypertension
* Polymorphisms
* Triglyceridemia
* Uric acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077001
}}
==ABL1==


===Keywords===
{{medline-entry
Aging; ER stress; Peromyscus
|title=European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32127639


==Assessing the Accessibility of Content for Geriatric Fellowship Programs.==
|mesh-terms=* Aniline Compounds
===Abstract===
* Antineoplastic Agents
The information available on program websites concerning geriatric fellowships in internal medicine and family medicine is a crucial factor in generating applicants' interest in individual programs. Our study aimed to quantify the accessibility and quality of information available on accredited geriatric (family medicine and internal medicine) fellowship program websites and further analyze the implications of the results obtained. A list of geriatric (family medicine and internal medicine) fellowship programs was analyzed through quantified measures after being verified for accreditation. Certain criteria were evaluated for each of these programs, such as website accessibility and whether critical information was available on online program websites. These criteria were centered on academic, administrative, and application-based factors. Hundred and fifty eight Family Medicine and Internal Medicine geriatric fellowship programs were identified in total, of which only 150 were accredited by the Accreditation Council for Graduate Medical Education and considered for analysis. Of these, 20 (13.33%) programs had website links that were nonfunctional and only 145 programs had websites at all. On programs' websites, information regarding aspects such as contact information-including phone number or email for the program-were lacking. Other information regarding past and current fellows, research, and curriculum were also generally lacking. Geriatric Fellowship websites in Family Medicine and Internal Medicine can gain better traction from those interested in applying for their programs by updating information more often and providing more and better information concerning critical aspects of the programs themselves online.
* Clinical Decision-Making
* Consensus Development Conferences as Topic
* Dasatinib
* Disease Management
* Fusion Proteins, bcr-abl
* Gene Expression
* Humans
* Imatinib Mesylate
* Leukemia, Myelogenous, Chronic, BCR-ABL Positive
* Life Expectancy
* Monitoring, Physiologic
* Nitriles
* Protein Kinase Inhibitors
* Pyrimidines
* Quality of Life
* Quinolines
* Survival Analysis


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214240
-
}}
==ABO==


===Keywords===
{{medline-entry
accessibility; fellowship content; geriatrics
|title=Allelic distribution of [i][[ABO]][/i] gene in Chinese centenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103040


==Where does cellular senescence belong in the pathophysiology of ovarian cancer?==
===Abstract===
Although ovarian cancer is the leading cause of death from gynecological malignancies, there are still some issues that hamper accurate interpretation of the complexity of cellular and molecular events underlying the pathophysiology of this disease. One of these is cellular senescence, which is the process whereby cells irreversibly lose their ability to divide and develop a phenotype that fuels a variety of age-related diseases, including cancer. In this review, various aspects of cellular senescence associated with intraperitoneal ovarian cancer metastasis are presented and discussed, including mechanisms of senescence in normal peritoneal mesothelial cells; the role of senescent mesothelium in ovarian cancer progression; the effect of drugs commonly used as first-line therapy in ovarian cancer patients on senescence of normal cells; mechanisms of spontaneous senescence in ovarian cancer cells; and, last but not least, other pharmacologic strategies to induce senescence in ovarian malignancies. Collectively, this study shows that cellular senescence is involved in several aspects of ovarian cancer pathobiology. Proper understanding of this phenomenon, particularly its clinical relevance, seems to be critical for oncology patients from both therapeutic and prognostic perspectives.


===MeSH Terms===
|keywords=* ABO gene
-
* centenarian
* longevity
* single nucleotide polymorphisms
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574633
}}
{{medline-entry
|title=Genetically Determined [[ABO]] Blood Group and its Associations With Health and Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31969017


===Keywords===
|mesh-terms=* ABO Blood-Group System
cancer metastasis; cellular senescence; ovarian cancer; peritoneal mesothelial cells; tumor microenvironment
* Adult
* Age Factors
* Aged
* Cardiovascular Diseases
* Female
* Gene Frequency
* Genetic Predisposition to Disease
* Health Status
* Healthy Aging
* Humans
* Incidence
* Male
* Middle Aged
* Phenotype
* Polymorphism, Single Nucleotide
* Prevalence
* Risk Assessment
* Risk Factors
* United Kingdom
|keywords=* ABO
* aging
* blood
* genetics
* hypertension
* phenotype
|full-text-url=https://sci-hub.do/10.1161/ATVBAHA.119.313658
}}
==ABR==


==[Metabolic syndrome as a gerontological problem (literature review).]==
{{medline-entry
===Abstract===
|title=[Hidden hearing loss and early identification].
Metabolic syndrome is a complex of interrelated disorders of carbohydrate and fat metabolism, as well as mechanisms for regulating blood pressure and endothelial function, which are based on a decrease in tissue sensitivity to insulin. Therefore, the leading component, pathophysiological basis and uniting factor of most of the symptoms described in metabolic syndrome is the resistance of peripheral tissues to the action of insulin, which is closely correlated with most metabolic disorders. It should be emphasized that almost all components of metabolic syndrome are established risk factors for developing cardiovascular diseases. The likelihood of developing metabolic syndrome increases with age. The article discusses the possibility of presenting the metabolic syndrome as a gerontological problem.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32791650


===MeSH Terms===
|mesh-terms=* Acoustic Stimulation
-
* Audiometry, Pure-Tone
 
* Auditory Threshold
===Keywords===
* Evoked Potentials, Auditory, Brain Stem
aging; gerontology; metabolic syndrome; pathogenesis
* Hearing Loss, Noise-Induced
 
==Visualization of Guideline-Based Decision Support for the Management of Pressure Ulcers in Nursing Homes.==
===Abstract===
Though a preventable risk, the management of pressure ulcers (PUs) in nursing homes is not satisfactory due to inadequate prevention and complex care plans. PUs early detection and wound assessment require to know the patient condition and risk factors and to have a good knowledge of best practices. We built a guideline-based clinical decision support system (CDSS) for the prevention, the assessment, and the management of PUs. Clinical practice guidelines have been modeled as decision trees and formalized as IF-THEN rules to be triggered by electronic health record (EHR) data. From PU assessment yielded by the CDSS, we propose a synthetic visualization of PU current and previous stages as a gauge that illustrates the different stages of PU continuous evolution. This allows to display PU current and previous stages to inform health care professionals of PU updated assessment and support their evaluation of previously delivered care efficiency. The CDSS will be integrated in NETSoins nursing homes EHR where gauges for several health problems constitute a patient dashboard.
 
===MeSH Terms===
Decision Support Systems, Clinical
* Electronic Health Records
* Health Personnel
* Humans
* Humans
* Nursing Homes
* Noise
* Pressure Ulcer
|keywords=* aging
* drug damage
* hidden hearing loss
* noise exposure
|full-text-url=https://sci-hub.do/10.13201/j.issn.2096-7993.2020.07.023
}}
{{medline-entry
|title=Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327469


===Keywords===
Clinical decision support system; clinical practice guidelines; geriatrics; information display; nursing homes; pressure ulcer


==Is ergothioneine a 'longevity vitamin' limited in the American diet?==
|keywords=* age-related hearing loss
===Abstract===
* aging
There is mounting evidence for the potential for the natural dietary antioxidant and anti-inflammatory amino acid l-Ergothioneine (ERGO) to prevent or mitigate chronic diseases of aging. This has led to the suggestion that it could be considered a 'longevity vitamin.' ERGO is produced in nature only by certain fungi and a few other microbes. Mushrooms are, by far, the leading dietary source of ERGO, but it is found in small amounts throughout the food chain, most likely due to soil-borne fungi passing it on to plants. Because some common agricultural practices can disrupt beneficial fungus-plant root relationships, ERGO levels in foods grown under those conditions could be compromised. Thus, research is needed to further analyse the role agricultural practices play in the availability of ERGO in the human diet and its potential to improve our long-term health.
* mouse primary auditoy cortex
* parvalbumin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210488
}}
{{medline-entry
|title=Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948760


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Apolipoproteins E
* Apoptosis
* Diet, Western
* Disease Models, Animal
* Hearing Loss
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Neurons
* Spiral Ganglion
|keywords=* Apoptosis
* Atherosclerosis
* Hearing loss
* Reactive oxygen specie
* Spiral ganglion neurons
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.12.100
}}
{{medline-entry
|title=Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771637


===Keywords===
|mesh-terms=* Aging
Antioxidant; ERGO, Ergothioneine; ETT, ERGO transporter; Ergothioneine; Fungi; Longevity vitamin; Regenerative agriculture
* Animals
* Body Weight
* Caenorhabditis elegans Proteins
* Cochlea
* Evoked Potentials, Auditory, Brain Stem
* Fatty Acid Desaturases
* Fatty Acids, Omega-3
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Neurons
* Presbycusis
* Spiral Ganglion
|keywords=* Age-related hearing loss
* C57BL/6 mouse
* Cochlea
* Omega-3 (n-3) fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878677
}}
{{medline-entry
|title=Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31601840


==Prevalence of Atrophic and Hypertrophic Skin Ageing Phenotypes: A UK-based Observational Study.==
|mesh-terms=* Aging
===Abstract===
* Animals
---
* Cochlea
* Evoked Potentials, Auditory, Brain Stem
* Genotype
* Hearing
* Hearing Loss
* Inflammation
* Male
* Mice
* Mice, Knockout
* Models, Animal
* Neovascularization, Pathologic
* Neurons
* Pituitary Adenylate Cyclase-Activating Polypeptide
* Proteome
* Proto-Oncogene Proteins c-fos


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787024
-
}}
{{medline-entry
|title=Global nurse/midwife workforce and reproductive health through social ecology lens.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31402489


===Keywords===
|mesh-terms=* Adolescent
skin aging;  skin neoplasms; prevalence
* Cross-Sectional Studies
* Employment
* Female
* Global Health
* Health Education
* Humans
* Income
* Life Expectancy
* Male
* Midwifery
* Pregnancy
* Reproductive Health
* Social Environment
* Socioeconomic Factors
* Workforce
|keywords=* global health
* nurse/midwife workforce
* reproductive health
* social ecology
|full-text-url=https://sci-hub.do/10.1111/phn.12648
}}
==ACD==


==Pathogen burden and leukocyte telomere length in the United States.==
{{medline-entry
===Abstract===
|title=Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.
Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimated cross-sectional associations between seropositivity to five persistent pathogens (Herpes Simplex Virus Type-1 (HSV-1), Herpes Simplex Virus Type-2 (HSV-2), cytomegalovirus (CMV), Helicobacter pylori (H.pylori), and Hepatitis B) as well as total pathogen burden and leukocyte telomere length. Data were derived from the National Health and Nutrition Examination Survey (1999-2000) for individuals 20-49 years of age, N = 1708. We analyzed the influence of each pathogen separately, a pathogen count score and a latent class model of pathogen burden on log telomere length using linear regression models, adjusted for covariates. Individuals in a latent pathogen burden class characterized by high probabilities of infection with HSV-1, CMV, and H. pylori, had significantly decreased log telomere length (- 0.30 [95% CI: - 0.36, - 0.24]) compared to those in a latent class characterized by low probabilities of all five infections. There were limited significant associations using other pathogen measures. These results suggest that infection with specific combinations of pathogens may be one mechanism contributing to accelerated cellular senescence with possible origins early in the life course.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792241


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Aged
* Aging
* Brazil
* Cognition
* Cognitive Dysfunction
* Cohort Studies
* Female
* Follow-Up Studies
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Humans
* Male
* Middle Aged
* Polymorphism, Single Nucleotide


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889148
Biological aging; Geroscience; Immunosenescence; Persistent infections; Telomere length
}}
==ACE==


==Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions.==
{{medline-entry
===Abstract===
|title=Elite swimmers possess shorter telomeres than recreationally active controls.
A complete picture of how subcortical nodes, such as the thalamus, exert directional influence on large-scale brain network interactions across age remains elusive. Using directed functional connectivity and weighted net causal outflow on resting-state fMRI data, we provide evidence of a comprehensive reorganization within and between neurocognitive networks (default mode: DMN, salience: SN, and central executive: CEN) associated with age and thalamocortical interactions. We hypothesize that thalamus subserves both modality-specific and integrative hub role in organizing causal weighted outflow among large-scale neurocognitive networks. To this end, we observe that within-network directed functional connectivity is driven by thalamus and progressively weakens with age. Secondly, we find that age-associated increase in between CEN- and DMN-directed functional connectivity is driven by both the SN and the thalamus. Furthermore, left and right thalami act as a causal integrative hub exhibiting substantial interactions with neurocognitive networks with aging and play a crucial role in reconfiguring network outflow. Notably, these results were largely replicated on an independent dataset of matched young and old individuals. Our findings strengthen the hypothesis that the thalamus is a key causal hub balancing both within- and between-network connectivity associated with age and maintenance of cognitive functioning with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068677


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
directed functional connectivity; healthy aging; multivariate Granger causality; salience network; thalamus; weighted net causal outflow
* Athlete
* Exercise
* Genetics
|full-text-url=https://sci-hub.do/10.1016/j.gene.2020.145242
}}
{{medline-entry
|title=Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850927


==Association between physical disability and incidence of depressive symptoms in older Mexican adults==
===Abstract===
Introduction: Functional limitations associated with the aging process can lead to the development of depressive symptoms and increase the vulnerability of older adults.
Objective: To estimate the association between physical disability and the incidence of clinically significant depressive symptoms in older Mexican adults.
Materials and methods: We conducted a retrospective cohort study with data from the Encuesta Nacional sobre Salud y Envejecimiento en México (ENASEM). The analytical sample (n=6,780) included adults over 50 years old with measurements for the main variables and no clinically significant depressive symptoms reported in the first round. These symptoms were evaluated with the CESD-9 scale and disability by means of the report of activities of daily living (ADL) or instrumental activities of daily living (IADL). Descriptive, bivariate, and multivariate analyses were performed using logistic regression models adjusted by sociodemographic variables, health conditions, childhood adversities, social participation, and stressful life events.
Results: The incidence of clinically significant depressive symptoms was 25.75% (95% CI: 24,70 - 26,80). Compared to those without IADL limitations, an increased risk of 68% for the development of clinically significant depressive symptoms was found (95% CI: 1.10-2.57; p= 0,015). With the ADL model, the OR for the development of clinically significant depressive symptoms was 1.36 (1.01 -1.81; p= 0.039). Both models were adjusted by confounding variables.
Conclusion: Presenting limitations in daily life is an important risk factor for the development of clinically significant depressive symptoms at two years of follow-up.


===MeSH Terms===
|keywords=* ACE2
-
* ACEIs
* ARBs
* COVID-19
* RAS
* SARS-CoV-2
* geriatrics
* neuropsychiatric disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431869
}}
{{medline-entry
|title=Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32755410


===Keywords===
Aged; disabled persons; depression; disability evaluation; incidence; aging; longitudinal studies; México


==Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.==
|keywords=* aging
===Abstract===
* endothelin
Human pluripotent stem cell (hPSC)-derived progenies are immature versions of cells, presenting a potential limitation to the accurate modelling of diseases associated with maturity or age. Hence, it is important to characterise how closely cells used in culture resemble their native counterparts. In order to select appropriate time points of retinal pigment epithelium (RPE) cultures that reflect native counterparts, we characterised the transcriptomic profiles of the hPSC-derived RPE cells from 1- and 12-month cultures. We differentiated the human embryonic stem cell line H9 into RPE cells, performed single-cell RNA-sequencing of a total of 16,576 cells to assess the molecular changes of the RPE cells across these two culture time points. Our results indicate the stability of the RPE transcriptomic signature, with no evidence of an epithelial-mesenchymal transition, and with the maturing populations of the RPE observed with time in culture. Assessment of Gene Ontology pathways revealed that as the cultures age, RPE cells upregulate expression of genes involved in metal binding and antioxidant functions. This might reflect an increased ability to handle oxidative stress as cells mature. Comparison with native human RPE data confirms a maturing transcriptional profile of RPE cells in culture. These results suggest that long-term in vitro culture of RPE cells allows the modelling of specific phenotypes observed in native mature tissues. Our work highlights the transcriptional landscape of hPSC-derived RPE cells as they age in culture, which provides a reference for native and patient samples to be benchmarked against.
* menopause
* nitric oxide
* renin-angiotensin system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429272
}}
{{medline-entry
|title=Heart failure is associated with accelerated age related metabolic bone disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32498656


===MeSH Terms===
-


===Keywords===
|keywords=* Heart failure
Aging; Human embryonic stem cell; Human pluripotent stem cell; Retinal pigment epithelium; Single-cell RNA sequencing
* comorbidities
* geriatrics
* metabolic bone disease
* osteoporosis
|full-text-url=https://sci-hub.do/10.1080/00015385.2020.1771885
}}
{{medline-entry
|title=Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32383033


==Season-of-birth phenomenon in health and longevity: epidemiologic evidence and mechanistic considerations.==
|mesh-terms=* Aged
===Abstract===
* Geriatrics
In many human populations, especially those living in regions with pronounced climatic differences between seasons, the most sensitive (prenatal and neonatal) developmental stages occur in contrasting conditions depending on the season of conception. The difference in prenatal and postnatal environments may be a factor significantly affecting human development and risk for later life chronic diseases. Factors potentially contributing to this kind of developmental programming include nutrition, outdoor temperature, infectious exposures, duration of sunlight, vitamin D synthesis, etc. Month of birth is commonly used as a proxy for exposures which vary seasonally around the perinatal period. Season-of-birth patterns have been identified for many chronic health outcomes. In this review, the research evidence for the seasonality of birth in adult-life disorders is provided and potential mechanisms underlying the phenomenon of early life seasonal programming of chronic disease and longevity are discussed.
* Heart Failure
* Humans
* Italy
* Specialization
* Stroke Volume
* Surveys and Questionnaires
|keywords=* Aged, 65 years or over
* Care survey
* Health
* Heart failure
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01577-1
}}
{{medline-entry
|title=Angiotensin-Converting Enzyme ([[ACE]]) genetic variation and longevity in Peruvian older people: a cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281429


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Cross-Sectional Studies
* Female
* Genetic Variation
* Humans
* Longevity
* Male
* Middle Aged
* Peptidyl-Dipeptidase A
* Peru
* Polymorphism, Genetic
|keywords=* ACE gene
* Longevity
* Perú
* ageing
|full-text-url=https://sci-hub.do/10.1080/03014460.2020.1748227
}}
{{medline-entry
|title=COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32229706


===Keywords===
|mesh-terms=* Age Factors
DOHaD; developmental programming; disease risk; longevity; seasonality of birth
* Aged
* Aged, 80 and over
* Aging
* Angiotensin-Converting Enzyme 2
* Antiviral Agents
* Azithromycin
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* Dipeptidyl Peptidase 4
* Humans
* Hydroxychloroquine
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Quercetin
* Receptors, Virus
* SARS-CoV-2
|keywords=* Azithromycin
* COVID-19
* Doxycycline
* Hydroxy-chloroquine
* Quercetin
* Rapamycin
* aging
* antibiotic
* corona virus
* drug repurposing
* prevention
* senescence
* senolytic drug therapy
* viral replication
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202514
}}
{{medline-entry
|title=[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The [[ACE]]S Trial): Study Protocol of a Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039215


==Effects of Caloric Restriction on the Antagonistic and Integrative Hallmarks of Aging.==
===Abstract===
Aging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes 'healthy brain aging' very important. Studies suggest that caloric restriction (CR) is a non-genetic intervention that reliably extends life- and healthspan. Here, we review the CR literature related to both the subject of aging and alterations in cell cycle machinery, especially surrounding the regulation of the E2F/DP1 complex, to elucidate the cellular protection mechanisms in the brain induced via dietary applications. The alterations extending lifespan via CR appear to exert their effects by promoting survival of individual cells, downregulating cell proliferation, and inducing stem cell quiescence, which results in keeping the stem cell reserve for extreme needs. This survival instinct of cells is believed to cause some molecular adaptations for their maintenance of the system. Avoiding energy waste of proliferation machinery promotes the long term survival of the individual cells and this is due to adaptations to the limited nutrient supply in the environment. Such a protective mechanism induced by diet could be promoted via the downregulation of crucial cell cycle-related transcription activators. This review article aims to bring attention to the importance of molecular adaptations induced by diet that promote healthy brain aging. It will provide insights into alternative targets for new treatments or neuroprotective approaches against neurodegenerative pathophysiologies.


===MeSH Terms===
|keywords=* aging
-
* antihypertensive
* exercise
* functional status
* hypertension
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988302
}}
{{medline-entry
|title=Vascular age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32013519


===Keywords===
|mesh-terms=* Adolescent
Aging; Brain; Calorie Restriction; Cell Cycle; Neuroinflammation
* Adult
* Aged
* Aging
* Angiotensin-Converting Enzyme Inhibitors
* Atherosclerosis
* Child
* Elasticity
* Humans
* Middle Aged
* Perindopril
* Pulse Wave Analysis
* Vascular Stiffness
* Young Adult
|keywords=* ACE inhibitors
* CT angiography
* atorvastatin
* dyslipidemia
* hypertension
* intima media thickness (IMT)
* perindopril
* pulse wave velocity (PWV)
* statins
* vascular age


==Alteration of the Intra- and Inter-Lobe Connectivity of the Brain Structural Network in Normal Aging.==
}}
===Abstract===
==ACE2==
The morphological changes in cortical parcellated regions during aging and whether these atrophies may cause brain structural network intra- and inter-lobe connectivity alterations are subjects that have been minimally explored. In this study, a novel fractal dimension-based structural network was proposed to measure atrophy of 68 parcellated cortical regions. Alterations of structural network parameters, including intra- and inter-lobe connectivity, were detected in a middle-aged group (30-45 years old) and an elderly group (50-65 years old). The elderly group exhibited significant lateralized atrophy in the left hemisphere, and most of these fractal dimension atrophied regions were included in the regions of the "last-in, first-out" model. Globally, the elderly group had lower modularity values, smaller component size modules, and fewer bilateral association fibers. They had lower intra-lobe connectivity in the frontal and parietal lobes, but higher intra-lobe connectivity in the temporal and occipital lobes. Both groups exhibited similar inter-lobe connecting pattern. The elderly group revealed separations, sparser long association fibers, commissural fibers, and lateral inter-lobe connectivity lost effect, mainly in the right hemisphere. New wiring and reconfiguring modules may have occurred within the brain structural network to compensate for connectivity, decreasing and preventing functional loss in cerebral intra- and inter-lobe connectivity.


===MeSH Terms===
{{medline-entry
-
|title=How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304284


===Keywords===
aging; brain structural network; inter-lobe connectivity; intra-lobe connectivity


==Racial Discrimination and Telomere Length in Midlife African American Women: Interactions of Educational Attainment and Employment Status.==
|keywords=* ACE2
===Abstract===
* Alzheimer disease
Over the life course, African American (AA) women have faster telomere attrition, a biological indicator of accelerated aging, than White women. Race, sex, age, and composite socioeconomic status (SES) modify associations of institutional racial discrimination and telomere length. However, interactions with everyday racial discrimination have not been detected in AA women, nor have interactions with individual socioeconomic predictors. We estimated statistical interaction of institutional and everyday racial discrimination with age, education, employment, poverty, and composite SES on telomere length among midlife AA women. Data are from a cross-section of 140 AA women aged 30-50 years residing in the San Francisco Bay Area. Participants completed questionnaires, computer-assisted self-interviews, physical examinations, and blood draws. Adjusted linear regression estimated bootstrapped racial discrimination-relative telomere length associations with interaction terms. Racial discrimination did not interact with age, poverty, or composite SES measures to modify associations with telomere length. Interactions between independent SES variables were nonsignificant for everyday discrimination whereas institutional discrimination interacted with educational attainment and employment status to modify telomere length. After adjusting for covariates, we found that higher institutional discrimination was associated with shorter telomeres among employed women with lower education (β = -0.020; 95% confidence interval = -0.036, -0.003). Among unemployed women with higher education, higher institutional discrimination was associated with longer telomeres (β = 0.017; 95% confidence interval = 0.003, 0.032). Factors related to having a post-high school education may be protective against the negative effects of institutional racism on cellular aging for AA women.
* Ang(1-7)/Mas
* COVID-19
* RAAS
* SARS-CoV
* brain aging
* neurodegenerative and psychiatric disorders abstract
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701095
}}
{{medline-entry
|title=Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33112891


===MeSH Terms===
|mesh-terms=* Aging
-
* Angiotensin-Converting Enzyme 2
* Betacoronavirus
* Binding Sites
* COVID-19
* Carrier Proteins
* Computational Biology
* Coronavirus Infections
* Female
* Gene Expression Regulation, Enzymologic
* Gene Ontology
* Humans
* Interferons
* Lung
* Male
* Metalloproteases
* Neovascularization, Physiologic
* Organ Specificity
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Promoter Regions, Genetic
* RNA, Messenger
* Receptors, Virus
* Renin-Angiotensin System
* SARS-CoV-2
* Sex Characteristics
* Single-Cell Analysis
* Transcription Factors
* Transcription Initiation Site
* Virus Attachment


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592753
African Americans; Aging; Educational status; Employment; Telomeres; Women’s Health
}}
{{medline-entry
|title=A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32854108


==Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation.==
|mesh-terms=* Aging
===Abstract===
* Angiotensin-Converting Enzyme 2
We have recently reported on an experimental model of mitochondrial mistranslation conferred by amino acid exchange V338Y in the mitochondrial ribosomal protein MrpS5. Here we used a combination of RNA-Seq and metabolic profiling of homozygous transgenic MrpS5V338Y/V338Y mice to analyze the changes associated with the V338Y mutation in post-mitotic skeletal muscle. Metabolic profiling demonstrated age-dependent metabolic changes in the mutant V338Y animals, which included enhanced levels of age-associated metabolites and which were accompanied by increased glycolysis, lipid desaturation and eicosanoid biosynthesis, and alterations of the pentose phosphate pathway. In addition, transcriptome signatures of aged V338Y mutant muscle pointed to elevated inflammation, likely reflecting the increased levels of bioactive lipids. Our findings indicate that mistranslation-mediated chronic impairment of mitochondrial function affects specific bioenergetic processes in muscle in an age-dependent manner.
* Animals
* Betacoronavirus
* COVID-19
* COVID-19 Vaccines
* Coronavirus Infections
* Disease Models, Animal
* Female
* Forkhead Transcription Factors
* Humans
* Interferon-alpha
* Interferons
* Interleukins
* Male
* Mice
* Mice, Inbred BALB C
* Mice, Transgenic
* Models, Molecular
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Receptors, Virus
* SARS-CoV-2
* Viral Vaccines


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2708-8
-
}}
{{medline-entry
|title=COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32765939


===Keywords===
Aging; Metabolome; Misreading; Mitochondria; Skeletal Muscle


==Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins.==
|keywords=* acetyl-carnosine
===Abstract===
* aging
Oxidative stress is currently considered to be the main cause of brain aging. Astaxanthin can improve oxidative stress under multiple pathological conditions. It is therefore hypothesized that astaxanthin might have therapeutic effects on brain aging. To validate this hypothesis and investigate the underlying mechanisms, a mouse model of brain aging was established by injecting amyloid beta (Aβ)25-35 (5 μM, 3 μL/injection, six injections given every other day) into the right lateral ventricle. After 3 days of Aβ  injections, the mouse models were intragastrically administered astaxanthin (0.1 mL/d, 10 mg/kg) for 30 successive days. Astaxanthin greatly reduced the latency to find the platform in the Morris water maze, increased the number of crossings of the target platform, and increased the expression of brain-derived neurotrophic factor, synaptophysin, sirtuin 1, and peroxisome proliferator-activated receptor-γ coactivator 1α. Intraperitoneal injection of the sirtuin 1 inhibitor nicotinamide (500 μM/d) for 7 successive days after astaxanthin intervention inhibited these phenomena. These findings suggest that astaxanthin can regulate the expression of synaptic proteins in mouse hippocampus through the sirtuin 1/peroxisome proliferator-activated receptor-γ coactivator 1α signaling pathway, which leads to improvements in the learning, cognitive, and memory abilities of mice. The study was approved by the Animal Ethics Committee, China Medical University, China (approval No. CMU2019294) on January 15, 2019.
* carnosine
* inflammation
* lungs
* olfaction
* virus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390525
}}
{{medline-entry
|title=The dual impact of [[ACE2]] in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32653522


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Aged
* Aged, 80 and over
* Angiotensin-Converting Enzyme 2
* Anti-Inflammatory Agents
* Betacoronavirus
* COVID-19
* Child
* Child, Preschool
* Coronavirus
* Coronavirus Infections
* Female
* Geriatrics
* Humans
* Infant
* Infant, Newborn
* Male
* Pandemics
* Pediatrics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Protein Binding
* Receptors, Virus
* Renin-Angiotensin System
* SARS-CoV-2
* Severe Acute Respiratory Syndrome
* Virus Internalization
|keywords=* ACE2
* Angiotensin 2
* Angiotensin-(1–7)
* Corona virus
* Glycoprotein spikes
* RAAS system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347488
}}
{{medline-entry
|title=The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529477


===Keywords===
|mesh-terms=* Adipocytes
brain aging; cognitive; factor; hippocampus; learning; memory; oxidative stress; pathways; synapse
* Age Factors
* Aged
* Aging
* Angiotensin II Type 2 Receptor Blockers
* Autophagy
* Betacoronavirus
* COVID-19
* Cellular Senescence
* Coronavirus Infections
* Cytokine Release Syndrome
* Cytokines
* Humans
* Immune System
* Inflammation
* Pandemics
* Pneumonia, Viral
* Reactive Oxygen Species
* Receptor, Angiotensin, Type 2
* SARS-CoV-2
* Vitamin D
* Vitamin D Deficiency
|keywords=* ACE2 receptor
* Autophagy
* COVID-19
* Cytokine storm
* Senescent cell
* Vitamin D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289226
}}
{{medline-entry
|title=Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32510973


==How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.==
|mesh-terms=* Adaptive Immunity
===Abstract===
* Angiotensin-Converting Enzyme 2
Interstitial pneumonia was the first manifestation to be recognized as caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, in just a few weeks, it became clear that the coronavirus disease-2019 (COVID-19) overrun tissues and more body organs than just the lungs, so much so that it could be considered a systemic pathology. Several studies reported the involvement of the conjunctiva, the gut, the heart and its pace, and vascular injuries such as thromboembolic complications and Kawasaki disease in children and toddlers were also described. More recently, it was reported that in a sample of 214 SARS-CoV-2 positive patients, 36.4% complained of neurological symptoms ranging from non-specific manifestations (dizziness, headache, and seizures), to more specific symptoms such hyposmia or hypogeusia, and stroke. Older individuals, especially males with comorbidities, appear to be at the highest risk of developing such severe complications related to the Central Nervous System (CNS) involvement. Neuropsychiatric manifestations in COVID-19 appear to develop in patients with and without pre-existing neurological disorders. Growing evidence suggests that SARS-CoV-2 binds to the human Angiotensin-Converting Enzyme 2 (ACE2) for the attachment and entrance inside host cells. By describing ACE2 and the whole Renin Angiotensin Aldosterone System (RAAS) we may better understand whether specific cell types may be affected by SARS-CoV-2 and whether their functioning can be disrupted in case of an infection. Since clear evidences of neurological interest have already been shown, by clarifying the topographical distribution and density of ACE2, we will be able to speculate how SARS-CoV-2 may affect the CNS and what is the pathogenetic mechanism by which it contributes to the specific clinical manifestations of the disease. Based on such evidences, we finally hypothesize the process of SARS-CoV-2 invasion of the CNS and provide a possible explanation for the onset or the exacerbation of some common neuropsychiatric disorders in the elderly including cognitive impairment and Alzheimer disease.
* Animals
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* DNA, Mitochondrial
* Gene Expression Regulation, Viral
* Host Microbial Interactions
* Humans
* Immunity, Innate
* Mitochondria
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* RNA, Viral
* SARS-CoV-2
* Virus Replication
|keywords=* COVID-19
* SARS-CoV
* aging
* coronavirus
* mitochondria
* mitochondrial DNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381712
}}
{{medline-entry
|title=A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32485164


===MeSH Terms===
|mesh-terms=* Aging
-
* Angiotensin-Converting Enzyme 2
* Animals
* Betacoronavirus
* Brain
* COVID-19
* CRISPR-Cas Systems
* Coronavirus Infections
* Cytokines
* Disease Models, Animal
* Gene Knock-In Techniques
* Lung
* Lung Diseases, Interstitial
* Mice, Inbred C57BL
* Nose
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* RNA, Viral
* SARS-CoV-2
* Stomach
* Trachea
* Viral Load
* Virus Replication
|keywords=* SARS-CoV-2
* angiotensin-converting enzyme II
* hACE2-KI/NIFDC
* mouse model
* pathogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250783
}}
{{medline-entry
|title=COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430627


===Keywords===
|mesh-terms=* Age Factors
ACE2; Alzheimer disease; Ang(1-7)/Mas; COVID-19; RAAS; SARS-CoV; brain aging; neurodegenerative and psychiatric disorders abstract
* Aged
* Betacoronavirus
* COVID-19
* Cardiovascular Diseases
* Coronavirus Infections
* Female
* Humans
* Italy
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* Risk Factors
* SARS-CoV-2
|keywords=* Acute myocardial injury
* Aging
* COVID-19
* Cardiovascular system
* Frailty
* SARS-CoV-2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237344
}}
{{medline-entry
|title=Gut microbiota and Covid-19- possible link and implications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430279


==Long-Term Stability of a RAFT-Modified Bulk-Fill Resin-Composite under Clinically Relevant Versus ISO-Curing Conditions.==
|mesh-terms=* Aging
===Abstract===
* Betacoronavirus
The addition of RAFT (reversible addition-fragmentation chain transfer) agents to the matrix formulation of a bulk-fill resin composite can significantly decrease the required curing time down to a minimum of 3 s. Evaluating the long term-stability of this resin composite in relation to varied curing conditions in an in-vitro environment was this study's goal. Specimens were produced according to either an ISO or one of two clinical curing protocols and underwent a maximum of three successive aging procedures. After each one of the aging procedures, 30 specimens for each curing condition were extracted for a three-point bending test. Fragments were then stereo-microscopically characterized according to their fracture mechanism. Weibull analysis was used to quantify the reliability of each aging and curing combination. Selected fragments ([i]n[/i] = 12) underwent further testing via depth-sensing indentation. Mechanical values for either standardized or clinical curing were mostly comparable. However, changes in fracture mechanism and Weibull modulus were observed after each aging procedure. The final procedure exposed significant differences in the mechanical values due to curing conditions. Curing conditions with increased radiant exposure seemingly result in a higher crosslink in the polymer-matrix, thus increasing resistance to aging. Yet, the clinical curing conditions still resulted in acceptable mechanical values, proving the effectiveness of RAFT-polymerization.
* COVID-19
* Coronavirus Infections
* Diet
* Dysbiosis
* Gastrointestinal Microbiome
* Gastrointestinal Tract
* Homeostasis
* Humans
* Immunity
* Lung
* Pandemics
* Pneumonia, Viral
* SARS-CoV-2
|keywords=* Covid-19
* Diet
* Dysbiosis
* Gut microbiome
* Immunity
* Lung microbiota
* SARS-CoV-2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217790
}}
{{medline-entry
|title=Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32389499


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Aging
* Angiotensin-Converting Enzyme 2
* Antibodies, Monoclonal, Humanized
* Betacoronavirus
* COVID-19
* Comorbidity
* Coronavirus Infections
* Female
* Humans
* Inflammation
* Interferon Type I
* Interleukin-6
* Male
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* SARS-CoV-2
* Severe Acute Respiratory Syndrome
|keywords=* COVID-19
* Cardiovascular diseases
* Host-directed therapies
* Inflamm-aging
* SARS-CoV-2
* interleukin-6
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252014
}}
{{medline-entry
|title=Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31571520


===Keywords===
RAFT-polymerization; Weibull analysis; accelerated aging; bulk-fill resin composite; curing conditions; depth-sensing indentation; fractography; long term-stability; three-point bending test


==Clinical and Neuropsychological Correlates of Prefrailty Syndrome.==
|keywords=* aging
===Abstract===
* cardiac hypertrophy index
Physical frailty is closely associated with cognitive impairment. We aim to investigate the neuropsychological profiles of prefrail and non-frail dementia-free community-dwelling older adults using a comprehensive neuropsychological evaluation, and to examine the association between specific frailty criteria and clinical and neuropsychological scores. Participants completed a comprehensive standardized neuropsychological evaluation (covering cognitive domains such as memory, executive functions, language and attention), and frailty assessment. Frailty was assessed according to biological criteria: unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. The sample comprised 60 dementia-free community-dwelling adults, aged 65 years or older (range 65-89 years; 60.0% women). Forty-two participants were classified as robust (no frailty criteria present), and 18 as prefrail (1 or 2 frailty criteria present). We explored neurocognitive differences between the groups and examined the association between specific criteria of frailty phenotype and clinical and neuropsychological outcomes with bivariate tests and multivariate models. Prefrail participants showed poorer cognitive performance than non-frail participants in both memory and non-memory cognitive domains. However, delayed episodic memory was the only cognitive subdomain that remained significant after controlling for age, gender, and educational level. Gait speed was significantly associated with general cognitive performance, immediate memory, and processing speed, while grip strength was associated with visual episodic memory and visuoconstructive abilities. Both gait speed and grip strength were negatively associated with depressive scores. Our results suggest that prefrailty is associated with cognitive dysfunction. The fact that specific cognitive domains may be susceptible to subclinical states of physical frailty may have important clinical implications. Indeed, early detection of specific cognitive dysfunctions may allow opportunities for reversibility.
* intermittent fasting
* renin–angiotensin system (RAS)
|full-text-url=https://sci-hub.do/10.1089/rej.2019.2254
}}
{{medline-entry
|title=Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in [[ACE2]]-knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31519791


===MeSH Terms===
|mesh-terms=* Adipose Tissue
-
* Aging
* Angiotensin I
* Angiotensin-Converting Enzyme 2
* Animals
* Body Weight
* Bone Resorption
* Cyclin-Dependent Kinase Inhibitor p16
* Forelimb
* Gene Deletion
* Hand Strength
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Muscle Weakness
* Muscles
* Organ Size
* PAX3 Transcription Factor
* Peptide Fragments
* Peptidyl-Dipeptidase A
* Proto-Oncogene Proteins
* Receptors, G-Protein-Coupled
* Renin-Angiotensin System
* Time Factors
|keywords=* Angiotensin 1-7
* Angiotensin Converting Enzyme 2
* Mas receptor
* Muscle weakness
* osteoporosis
|full-text-url=https://sci-hub.do/10.1042/CS20190573
}}
==ACLY==


===Keywords===
{{medline-entry
aging; gait speed; grip strength; neuropsychologial assessment; prefrailty
|title=In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666259


==[State of autonomic regulation of heart rhythm in young and aged rats before and after application of different regimens of rhythmic extreme cooling.]==
===Abstract===
The influence of various rhythmic extreme cold effects on the state of autonomic regulation of heart rate in young and aged rats was studied. According to the spectral analysis of heart rate variability, it has been found that in young rats, using rhythmic extreme cold exposures (RECE) temperature regimens of (-120 °С; -120 °С; -120 °С) and (-60 °С; -120 °С; -120 °С) significantly increased adaptive capabilities of the body due to the activation of its own homeostatic regulatory systems. At the same time, the combined regimen of RECE (-60 °С; 120 °С; -120 °С) occurred to be the most optimal for aged animals, since its use was not accompanied with an excessive activation of sympathoadrenal system at the early stages of experimental studies, in contrast to the regimen (120 °С; -120 °С; -120 °С). In addition, the use of this cooling mode contributed to a statistically significant increase in the total power of spectrum of neurohumoral regulation not so much due to a rise in activity of humoral-metabolic regulation link, the prevalence of which is characteristic of an old age, but due to an increase in the tone of vegetative centers, herewith the parasympathetic effects on the myocardium prevailed sympathetic ons.


===MeSH Terms===
|keywords=* Aging
-
* Apoptosis/necrosis
* Caloric restriction mimetics
* Hydroxycitric acid
* Oxidative stress
* Sch9 and Ras2 pathways
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527365
}}
==ACR==


===Keywords===
{{medline-entry
aging; autonomic nervous system; extreme rhythmic cold effects; heart rate variability
|title=Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32159757


==Personalized nutrition and healthy aging.==
===Abstract===
The human lifespan and quality of life depend on complex interactions among genetic, environmental, and lifestyle factors. Aging research has been remarkably advanced by the development of high-throughput "omics" technologies. Differences between chronological and biological ages, and identification of factors (eg, nutrition) that modulate the rate of aging can now be assessed at the individual level on the basis of telomere length, the epigenome, and the metabolome. Nevertheless, the understanding of the different responses of people to dietary factors, which is the focus of precision nutrition research, remains incomplete. The lack of reliable dietary assessment methods constitutes a significant challenge in nutrition research, especially in elderly populations. For practical and successful personalized diet advice, big data techniques are needed to analyze and integrate the relevant omics (ie, genomic, epigenomic, metabolomics) with an objective and longitudinal capture of individual nutritional and environmental information. Application of such techniques will provide the scientific evidence and knowledge needed to offer actionable, personalized health recommendations to transform the promise of personalized nutrition into reality.


===MeSH Terms===
|keywords=* p16
-
* primary Sjögren’s syndrome
* salivary gland
* salivary gland progenitor cells
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516109
}}
{{medline-entry
|title=Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655874


===Keywords===
aging; biological age; nutrition; omics; personalized nutrition; precision nutrition


==Biostimulant Effects of Glutacetine® and Its Derived Formulations Mixed With N Fertilizer on Post-heading N Uptake and Remobilization, Seed Yield, and Grain Quality in Winter Wheat.==
|keywords=* Aging
===Abstract===
* Jumping mechanography
Biostimulants could play an important role in agriculture particularly for increasing N fertilizer use efficiency that is essential for maintaining both yield and grain quality in bread wheat, which is a major global crop. In the present study, we examined the effects of mixing urea-ammonium-nitrate fertilizer (UAN) or urea with five new biostimulants containing Glutacetine® or its derivative formulations (VNT1, 2, 3, and 4) on the physiological responses, agronomic traits, and grain quality of winter wheat. A first experiment under greenhouse conditions showed that VNT1, VNT3, and VNT4 significantly increased the seed yield and grain numbers per ear. VNT4 also enhanced total plant nitrogen (N) and total grain N, which induced a higher N Harvest Index (NHI). The higher post-heading N uptake (for VNT1 and VNT4) and the acceleration of senescence speed with all formulations enabled better nutrient remobilization efficiency, especially in terms of N mobilization from roots and straw toward the grain with VNT4. The grain ionome was changed by the formulations with the bioavailability of iron improved with the addition of VNT4, and the phytate concentrations in flour were reduced by VNT1 and VNT4. A second experiment in three contrasting field trials confirmed that VNT4 increased seed yield and N use efficiency. Our investigation reveals the important role of these new formulations in achieving significant increases in seed yield and grain quality.
* Muscle
* Osteoarthritis
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994439
}}
==ACVR1==


===MeSH Terms===
{{medline-entry
-
|title=Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31998237


===Keywords===
Triticum aestivum; grain quality; iron bioavailability; nitrogen fertilizer; nitrogen remobilization; phytate; plant biostimulants; senescence


==Prevalence of lifetime nonmedical opioid use among U.S. Health Center Patients aged 45 years and older with psychiatric disorders.==
|keywords=* ACVR1
===Abstract===
* activin A
Despite recent concerns over the increase in opioid misuse among aging adults, little is known about the prevalence of lifetime nonmedical opioid use in underserved, vulnerable middle-aged and older patients with psychiatric disorders. This study aims to determine the lifetime prevalence of nonmedical opioid use among underserved, vulnerable U.S. adults aged ≥45 years with psychiatric disorders. A nationally representative sample ([i]n[/i] = 3,294) was obtained from the 2014 Health Center Patient Survey which collects data on psychiatric disorders, opioid use, and other health information from underserved, vulnerable U.S. primary care populations. Predictor variables included self-reported panic disorder, generalized anxiety disorder, schizophrenia, or bipolar disorder. The outcome variable was self-reported lifetime nonmedical opioid use. Frequencies, counts, and unadjusted and adjusted logistic regression models were conducted with the cross-sectional survey dataset. Patients with bipolar disorder had the highest lifetime nonmedical opioid use rate (20.8%), followed by schizophrenia (19.3%), panic disorder (16.5%), and generalized anxiety disorder (14.5%). Nonmedical opioid use was significantly associated with bipolar disorder (OR 3.46, 95% CI [1.33, 8.99]) and generalized anxiety disorder (OR 2.03 95% CI [1.08, 3.83]). Our findings demonstrate a high prevalence of lifetime nonmedical opioid use in underserved, vulnerable middle-aged and older health center patients with psychiatric disorders. Given the prevalence, health center professionals should monitor, prevent, and treat new or reoccurring signs and symptoms of nonmedical opioid use in this high-risk group of aging patients with psychiatric disorders.
* cell senescence
* fibrodysplasia ossificans progressiva
* progeroid syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966325
}}
==ADA==


===MeSH Terms===
{{medline-entry
-
|title=Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33023260


===Keywords===
Opioids; epidemiology; geriatric psychiatry; geriatrics; health centers; primary care


==Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.==
|keywords=* adenosine metabolism
===Abstract===
* aging
Naringenin is naturally isolated from citrus fruits possessing many pharmacological activities. However, little is known about the effect of naringenin on nonalcoholic steatohepatitis (NASH) in the model of metabolic syndrome. The present study is aimed to investigate the effect of naringenin on NASH in 12-mo-old male ApoE  mice and its possible underlying mechanism. In vivo, 12-mo-old male ApoE  mice were administrated with naringenin by intragastric gavage for 12 weeks. At the end of experiment, the blood samples and liver tissues were collected. Metabolic parameters in serum, levels of triglyceride, cholesterol and hydroxyproline, activities of antioxidant enzymes, and content of inflammatory cytokines (TNF-α and IL-6) in liver were examined by corresponding assay kits. Pathological changes in liver were observed by hematoxylin-eosin, oil red O, masson's trichrome, picro-sirius red and senescence β-galactosidase staining. Dihydroethidium was used for detection of reactive oxygen species (ROS). In vitro, AML-12 cells were treated with oleic acid in the presence or absence of naringenin for 24 h. Transfection of SIRT1 siRNA was also conducted in vitro. Lipid accumulation, cellular ROS generation, malondialdehyde content, antioxidant enzyme activities and secretion levels of TNF-α and IL-6 were examined. Both in vivo and in vitro, gene expressions were detected by real-time PCR or western blot. Naringenin administration improved metabolic parameters, suppressed hepatic steatosis, regulated expression of genes involved in lipid metabolism (FASN, SCD1, PPARα and CPT1α), reduced hepatic fibrosis and cell senescence, inhibited hepatic inflammation as evidenced by the decreased macrophage recruitment and content of TNF-α and IL-6, and reduced hepatic oxidative stress by suppressing ROS generation and normalizing activities of antioxidant enzymes. Notably, naringenin administration increased hepatic SIRT1 protein expression and activity along with the increased deacetylation of liver kinase B1 (LKB1), PGC1α and NF-κB. In vitro study, the benefits of naringenin on lipid accumulation, oxidative stress and inflammation were diminished by SIRT1 siRNA transfection. These results indicate that naringenin administration may be a potential curative therapy for NASH treatment and the activation of hepatic SIRT1-mediated signaling cascades is involved in its beneficial effects.
* animal models
* glutamate
* purinergic signaling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582336
}}
==ADAM10==


===MeSH Terms===
{{medline-entry
-
|title=NKG2D Ligand Shedding in Response to Stress: Role of [[ADAM10]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32269567


===Keywords===
AML-12 cells; Aging; ApoE(−/−) mice; Naringenin; Nonalcoholic steatohepatitis; SIRT1


==Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves.==
|keywords=* ADAM10
===Abstract===
* NKG2D
The role played by mitochondrial function in the aging process has been a subject of intense debate in the past few decades, as part of the efforts to understand the mechanistic basis of longevity. The mitochondrial oxidative stress theory of aging (MOSTA) suggests that a progressive decay of this organelle's function leads to an exacerbation of oxidative stress, with deleterious impact on mitochondrial structure and DNA, ultimately promoting aging. Among the traits suspected to be associated with longevity is the variation in regulation of oxidative phosphorylation, potentially impacting the management of oxidative stress. Longitudinal studies using the framework of metabolic control analysis have shown age-related differences in flux control of respiration, but this approach has seldom been taken on a comparative scale. Using four species of marine bivalves exhibiting a large range of maximum lifespans (from 28y to 507y), we report lifespan-related differences in flux control at different steps of the electron transfer system. Increased longevity was characterized by a lower control by NADH- (complex I-linked) and Succinate- (complex II- linked) pathways, while respiration was strongly controlled by complex IV when compared to shorter-lived species. Complex III exterted a strong control over respiration in all species. Furthermore, high longevity was associated with higher citrate synthase activity, and lower ATP synthase activity. Relieving the control exerted by the electron entry pathways could be advantageous for reaching a higher longevity, leading to an increased control by complex IV, the final electron acceptor in the electron transfer system.
* NKG2D ligands
* cancer
* chemotherapy
* senescence
* shedding
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109295
}}
{{medline-entry
|title=Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32050516


===MeSH Terms===
|mesh-terms=* ADAM10 Protein
-
* Aging
* Amyloid Precursor Protein Secretases
* Animals
* Cognition
* Epigenesis, Genetic
* Female
* Glial Fibrillary Acidic Protein
* Glycogen Synthase Kinase 3 beta
* Mechanistic Target of Rapamycin Complex 1
* Membrane Proteins
* Mice
* MicroRNAs
* NF-kappa B
* Reactive Oxygen Species
* Signal Transduction
* Stress, Psychological
|keywords=* Alzheimer’s disease
* SAMP8
* SAMR1
* age-related cognitive decline
* autophagy
* cognition
* epigenetics
* inflammation
* oxidative stress
* senescence
* stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037343
}}
==ADAM17==


===Keywords===
{{medline-entry
Invertebrate; Longevity; Metabolism; Mitochondria
|title=ACE2/[[ADAM17]]/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117379


==The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence.==
|mesh-terms=* ADAM17 Protein
===Abstract===
* Aged
Cellular senescence is a phenotypic state characterized by stable cell-cycle arrest, enhanced lysosomal activity, and the secretion of inflammatory molecules and matrix degrading enzymes. Senescence has been implicated in osteoarthritis (OA) pathophysiology; however, the mechanisms that drive senescence induction in cartilage and other joint tissues are unknown. While numerous physiological signals are capable of initiating senescence, one emerging theme is that damaged cells convert to senescence in response to sustained mitogenic stimulation. The goal of this study was to develop an in vitro articular cartilage explant model to investigate the mechanisms of senescence induction. This study utilized healthy cartilage derived from cadaveric equine stifles and human ankles. Explants were irradiated to initiate DNA damage, and mitogenic stimulation was provided through serum-containing medium and treatment with transforming growth factor β1 and basic fibroblastic growth factor. Readouts of senescence were a quantitative flow cytometry assay to detect senescence-associated β galactosidase activity (SA-β-gal), immunofluorescence for p16 and γH2AX, and qPCR for the expression of inflammatory genes. Human cartilage explants required both irradiation and mitogenic stimulation to induce senescence as compared to baseline control conditions (7.16% vs 2.34% SA-β-gal high, p = 0.0007). These conditions also resulted in chondrocyte clusters within explants, a persistent DNA damage response, increased p16, and gene expression changes. Treatment of cartilage explants with mitogenic stimuli in the context of cellular damage reliably induces high levels of SA-β-gal activity and other senescence markers, which provides a physiologically relevant model system to investigate the mechanisms of senescence induction.
* Aging
* Angiotensin-Converting Enzyme 2
* Betacoronavirus
* COVID-19
* Comorbidity
* Coronavirus Infections
* Female
* Humans
* Male
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Receptors, Interleukin-6
* Risk Factors
* SARS-CoV-2
* Serine Endopeptidases
* Tumor Necrosis Factor-alpha
|keywords=* ACE2
* ADAM17
* COVID-19 pathophysiology
* SARS-CoV-2
* TMPRSS2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575774
}}
==ADH5==


===MeSH Terms===
{{medline-entry
-
|title=Can Serum Nitrosoproteome Predict Longevity of Aged Women?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33260845


===Keywords===
Aging; DNA damage; Osteoarthritis; SA-β-gal; TGF- β1; bFGF


==The price of longevity.==
|keywords=* aging
===Abstract===
* cardiovascular disease
---
* muscle atrophy
* nitrosative stress
* proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731247
}}
==ADM==


===MeSH Terms===
{{medline-entry
-
|title=Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693193


===Keywords===
ataxin-3; autophagy; longevity; proteostasis; ubiquitin


==Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats.==
|keywords=* Aging
===Abstract===
* Decomposition-based quantitative electromyography (DQEMG)
Life expectancy has risen in the past decades, resulting in an increase in the number of aged individuals. Exercise remains one of the most cost-effective treatments against disease and the physical consequences of aging. The purpose of this research was to investigate the effects of aging, long-term and lifelong exercise on the rat urinary metabolome. Thirty-six male Wistar rats were divided into four equal groups: exercise from 3 to 12 months of age (A), lifelong exercise from 3 to 21 months of age (B), no exercise (C), and exercise from 12 to 21 months of age (D). Exercise consisted in swimming for 20 min/day, 5 days/week. Urine samples collection was performed at 3, 12 and 21 months of life and their analysis was conducted by liquid chromatography-mass spectrometry. Multivariate analysis of the metabolite data did not show any discrimination between groups at any of the three aforementioned ages. However, multivariate analysis discriminated the three ages clearly when the groups were treated as one. Univariate analysis showed that training increased the levels of urinary amino acids and possibly protected against sarcopenia, as evidenced by the higher levels of creatine in the exercising groups. Aging was accompanied by decreased levels of urinary amino acids and signs of increased glycolysis. Concluding, both aging and, to a lesser degree, exercise affected the rat urinary metabolome, including metabolites related to energy metabolism, with exercise showing a potential to mitigate the consequences of aging.
* Hand muscle
* Jiggle
* Motor unit potential (MUP)
* Multivariate
|full-text-url=https://sci-hub.do/10.1016/j.clinph.2020.06.017
}}
{{medline-entry
|title=Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31629715


===MeSH Terms===
-


===Keywords===
|keywords=* ADM system
aging; exercise; liquid chromatography-mass spectrometry (LC/MS); urinary metabolites
* Aging
* Biomarkers
* ET-1system
* LncRNA
* NP system
|full-text-url=https://sci-hub.do/10.1016/j.peptides.2019.170173
}}
==ADORA2B==


==Blood hormones and torque teno virus in peripheral blood mononuclear cells.==
{{medline-entry
===Abstract===
|title=Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.
Men and women respond differently to infectious diseases. Women show less morbidity and mortality, partially due to the differences in sex hormone levels which can influence the immune response. Torque teno virus (TTV) is non-pathogenic and ubiquitously present in serum from a large proportion (up to 90%) of adult humans with virus levels correlating with the status of the host immune response. The source of TTV replication is unknown, but T-lymphocytes have been proposed. In this study we investigated the presence and levels of TTV in peripheral blood mononuclear cells (PBMCs) in premenopausal (pre-MP) women, post-menopausal (post-MP) women, and men, and determined their serum sex hormone levels. Of the examined subjects ([i]n[/i] = 27), we found presence of TTV in PMBC from 17.6% pre-MP ([i]n[/i] = 17), 25.0% post-MP ([i]n[/i] = 4) and 50.0% men ([i]n[/i] = 6). The levels of TTV/μg DNA were lower among TTV-positive men and post-MP women compared to pre-MP women. All the positive pre-MP women were either anovulatory, hypothyroid, or both. In addition, the TTV-positive pre-MP women had significantly lower progesterone levels compared to TTV-negative pre-MP women. Although our study was performed on a limited number of subjects, the data suggests that TTV in PBMC is associated with an anovulatory menstrual cycle with low progesterone levels, and possibly with male sex.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33131093


===MeSH Terms===
-


===Keywords===
|keywords=* ADA-deficiency
Aging; Anovulatory; Commensal viruses; Estrogen; Hematology; Hypothyroidism; Immune response; Immunity; Immunodeficiency; Immunology; Infection; Infectious disease; Menstrual cycle; Microbiome; Reproductive hormone; Sex difference; Sex hormones; Steroid hormones; Viruses
* adenosine deaminase deficiency
* aging
* myelin protein zero
* myelination
|full-text-url=https://sci-hub.do/10.1096/fj.202000939R
}}
==ADRA2A==


==Warburg-like Metabolic Reprogramming in Aging Intestinal Stem Cells Contributes to Tissue Hyperplasia.==
{{medline-entry
===Abstract===
|title=α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.
In many tissues, stem cell (SC) proliferation is dynamically adjusted to regenerative needs. How SCs adapt their metabolism to meet the demands of proliferation and how changes in such adaptive mechanisms contribute to age-related dysfunction remain poorly understood. Here, we identify mitochondrial Ca  uptake as a central coordinator of SC metabolism. Live imaging of genetically encoded metabolite sensors in intestinal SCs (ISCs) of Drosophila reveals that mitochondrial Ca  uptake transiently adapts electron transport chain flux to match energetic demand upon proliferative activation. This tight metabolic adaptation is lost in ISCs of old flies, as declines in mitochondrial Ca  uptake promote a "Warburg-like" metabolic reprogramming toward aerobic glycolysis. This switch mimics metabolic reprogramming by the oncogene Ras  and enhances ISC hyperplasia. Our data identify a critical mechanism for metabolic adaptation of tissue SCs and reveal how its decline sets aging SCs on a metabolic trajectory reminiscent of that seen upon oncogenic transformation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33116632


===MeSH Terms===
-


===Keywords===
|keywords=* ADRA2A
Drosophila; Warburg; aging; calcium; cancer; intestine; metabolism; mitochondria; stem cell; tissue homeostasis
* PI3K/Akt/mTOR pathway
* cervical cancer
* metastasis
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574911
}}
==AFM==


==Entropic Approach to the Detection of Crucial Events.==
{{medline-entry
===Abstract===
|title=Photocatalytic aging process of Nano-TiO  coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy ([[AFM]]-IR) for nanoscale chemical characterization.
In this paper, we establish a clear distinction between two processes yielding anomalous diffusion and 1 / f noise. The first process is called Stationary Fractional Brownian Motion (SFBM) and is characterized by the use of stationary correlation functions. The second process rests on the action of crucial events generating ergodicity breakdown and aging effects. We refer to the latter as Aging Fractional Brownian Motion (AFBM). To settle the confusion between these different forms of Fractional Brownian Motion (FBM) we use an entropic approach properly updated to incorporate the recent advances of biology and psychology sciences on cognition. We show that although the joint action of crucial and non-crucial events may have the effect of making the crucial events virtually invisible, the entropic approach allows us to detect their action. The results of this paper lead us to the conclusion that the communication between the heart and the brain is accomplished by AFBM processes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080556


===MeSH Terms===
-


===Keywords===
|keywords=* AFM-IR
crucial events; ergodicity breakdown; heart-brain communication; renewal aging; renewal processes; stationary correlation function
* Aging process
* Microplastics
* Nanoscale characterization
* Polypropylene
|full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2020.124159
}}
{{medline-entry
|title=Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy ([[AFM]]-IR) technique.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32702545


==Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.==
===Abstract===
With the rising number of hip surgeries, simple and cost-effective tools for surgery risk assessment are warranted. The analysis of heart rate variability (HRV) may not only provide critical insights into the general frailty of patients with hip surgery, but also allow for better differentiation of health profiles in different hip surgery groups. Using HRV analysis, the present study compared cardiovascular as well as anthropometric parameters between patients with hip surgery, the hip fracture surgery group (HFS) and the total hip arthroplasty group (THA), and a control group. 71 participants (56.3% women), aged 60-85 years, took part, divided into three groups-patients after hip surgery (21 HFS and 30 THA patients) and a control group (20 participants). Electrocardiogram was recorded at baseline and after the application of a physical stressor (grip strength). A 3 (group) × 2 (time) repeated measures ANOVA, and a chi square test were carried out to test for group differences. Higher weight (p = .002), body mass index (p = .001), and systolic blood pressure (p = .034) were found in THA patients compared to HFS patients. Lower calf circumference (p = .009) and diastolic blood pressure (p = .048) were observed for the HFS group compared to the control group. For cardiovascular parameters, significant differences emerged between the HFS group and the control group in HR (p = .005), SDNN (p = .034) and SD2 (p = .012). No significant differences in cardiovascular parameters were observed between the two hip surgery groups: neither at baseline nor during stressor recovery. While HRV seems to differentiate well between HFS patients and controls, more research with larger samples is needed to scrutinize similaritites and differences in cardiovascular profiles between HFS and THA patients.


===MeSH Terms===
|keywords=* AFM-IR
-
* Aging process
* Mechanical properties
* Microplastics (MPs)
* Thermal analysis
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.140944
}}
{{medline-entry
|title=Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521351


===Keywords===
Aging; Cardiovascular reactivity; Heart rate variability; Hip fracture; Total hip arthroplasty


==The chronic effects of CuO and ZnO nanoparticles on Eisenia fetida in relation to the bioavailability in aged soils.==
|keywords=* AFM
===Abstract===
* Air plasma treatment
The bioavailability and bioaccumulation of metal-based engineered nanoparticles (ENPs) in soils need to be evaluated in environmentally relevant scenarios. The aim of this study was an analysis of potentially available metal-component ENPs (nano-ZnO and nano-CuO) in soils. Earthworms (Eisenia fetida) were used to examine the bioaccumulation potential of ENPs. Micro-particles (micro-ZnO and micro-CuO) and metal salts (ZnCl  and CuCl ) were used to evaluate the nano-effect and the activity of dissolved ions, respectively. Zn- and Cu-compounds were added to sandy loam and silt loam at a concentration of 10 mg kg . The bioavailable fractions of metals were extracted from soil using H O, MgCl  with CH COONa or EDTA. EDTA was the most effective extractant of Zn and Cu (10.06-11.65 mg Zn kg  and 2.69-3.52 mg Cu kg ), whereas the H O-extractable metal concentration was at the lowest level (1.98-2.12 mg Zn kg  and 0.54-0.82 Cu mg kg ). The bioavailable metal concentrations were significantly higher in silt loam than sandy loam soil, which was related to the higher pH value of silt. There were no significant differences between the Zn content in the earthworms incubated in the two soils, which may confirm the auto-regulation of the Zn content by earthworms. However, the bioaccumulation of Cu was strongly correlated with the extractable Cu concentrations. The juvenile earthworms accumulated Cu and Zn more than adults. Based on our results, aging neutralized the differences between the ionic and particulate effects of metal-compounds.
* Liquid aging
* PDMS
* Zeta potential
|full-text-url=https://sci-hub.do/10.1016/j.jcis.2020.05.061
}}
{{medline-entry
|title=Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429499


===MeSH Terms===
-


===Keywords===
|keywords=* AFM-IR
Aging; Bioaccumulation; Bioavailability; Eisenia fetida; Engineered nanoparticles; Extractability
* blends
* nanoscale characterization
* polymer aging
* polymer composites
* polymers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284686
}}
{{medline-entry
|title=Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32288071


==C1q/TNF-related protein-9 attenuates palmitic acid-induced endothelial cell senescence via increasing autophagy.==
===Abstract===
Autophagy is an important process in the pathogenesis of atherosclerosis. C1q/tumor necrosis factor-related protein 9 (CTRP9) is the closest adiponectin paralog. CTRP9 has anti-aging and anti-atherogenic effects, but its roles in autophagy and endothelial senescence are currently unknown. This study aimed to evaluate whether CTRP9 prevents palmitic acid (PA)-induced endothelial senescence by promoting autophagy. After no treatment or pre-treatment of human umbilical vein endothelial cells with CTRP9 prior to PA treatment, the level of senescence was measured by senescence associated acidic β-galactosidase staining and the level of hyperphosphorylated pRB protein. Autophagy was evaluated by LC3 conversion and the level of p62/SQSTM1, a protein degraded during autophagy. Autophagosome-lysosome fusion was detected by fluorescence microscopy. Pre-treatment with CTRP9 attenuated PA-induced endothelial senescence. CTRP9 increased the conversion of LC3-I to LC3-II and decreased p62 levels in a time- and dose-dependent manner. Although both CTRP9 and PA treatment increased LC3 conversion, treatment with PA increased the expression level of p62 and decreased the fusion of autophagosomes and lysosomes, which represented decreased autophagic flux. However, pre-treatment with CTRP9 recovered the autophagic flux inhibited by PA. AMP-activated kinase (AMPK) activation was involved in LC3 conversion and decreased p62 levels induced by CTRP9. CTRP9 inhibits PA-induced endothelial senescence by recovering autophagy and autophagic flux through AMPK activation.


===MeSH Terms===
|keywords=* AFM, active fraction of mannoproteins
-
* ALP, alkaline phosphatase
* ALT, alanine aminotransferase
* Ageing
* CBC, complete blood count
* CD21+, B lymphocyte
* CD4+, auxiliary T lymphocyte
* CD5+, total T lymphocyte
* CD8+, cytotoxic lymphocyte
* CO, cells only
* Canine
* DCHT, delayed cutaneous hypersensitivity test
* FOSs, fructooligosaccharides
* GALT, gut-associated lymphoid tissue
* IL-12, interleukin 12
* IgA, immunoglobulin A
* Immunosenescence
* LPS, bacterial lipopolysaccharide
* MOSs, mannanoligosaccharides
* NADPH, reduced nicotinamide adenine dinucleotide phosphate
* NO, nitrogen monoxide
* NOS, nitric oxide synthase
* OD, optical density
* PMA, phorbol myristate acetate
* Saccharomyces cerevisiae
* Senescence
* TNF-α, tumour necrosis factor alpha
* Th1, helper T lymphocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126846
}}
{{medline-entry
|title=The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32155867


===Keywords===
C1q/TNF-related protein-9; aging; atherosclerosis; autophagy; endothelial senescence


==Healthy aging interventions reduce repetitive element transcripts.==
|keywords=* Fourier transform infrared spectroscopy
===Abstract===
* atomic force microscopy
Transcripts from non-coding repetitive elements (RE) in the genome may be involved in aging. However, they are often ignored in transcriptome studies on healthspan and lifespan, and their role in healthy aging interventions has not been characterized. We analyze RE in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasing interventions including calorie restriction, rapamycin, acarbose, 17-⍺-estradiol, and Protandim. We also examine RE transcripts in long-lived transgenic mice, and in mice subjected to a high-fat diet, and we use RNA-seq to investigate the influence of aerobic exercise on RE transcripts with aging in humans. We find that: 1) healthy aging interventions/behaviors globally reduce RE transcripts, whereas aging and a high-fat diet increase RE expression; and 2) reduced RE expression with healthy aging interventions is associated with biological/physiological processes mechanistically linked with aging. RE transcript dysregulation and suppression are likely novel mechanisms underlying aging and healthy aging interventions, respectively.
* gel permeation chromatography
* ultraviolet aging
* waste engine oil
* waste polyethylene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182932
}}
{{medline-entry
|title=Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098962


===MeSH Terms===
|mesh-terms=* Aging
-
* Animal Feed
* Animals
* Bacillus subtilis
* Biomarkers
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Comamonas
* Escherichia coli
* Forkhead Transcription Factors
* Hot Temperature
* Insulin
* Microbiota
* Microscopy, Atomic Force
* Mutation
* Receptor, Insulin
* Signal Transduction
* Ultraviolet Rays


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042263
Non-coding RNA; RNA-seq; healthspan; lifespan; transposable elements
}}
{{medline-entry
|title=Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31513781


==Control of lifespan and survival by [i]Drosophila[/i] NF-κB signaling through neuroendocrine cells and neuroblasts.==
|mesh-terms=* Alzheimer Disease
===Abstract===
* Amyloid beta-Peptides
We report a comparative analysis of the effects of immune activation in the fly nervous system using genetic activation models to target [i]Drosophila[/i] NF-κB within Toll versus Imd pathways. Genetic gain-of-function models for either pathway pan-neuronally as well as in discrete subsets of neural cells including neuroendocrine insulin-producing cells (IPCs) or neuroblasts reduce fly lifespan, however, these phenotypes in IPCs and neuroblasts are stronger with Toll activation than Imd activation. Of note, while aging is influenced more by Toll/NF-κB activation in IPCs during adulthood, neuroblasts influence aging more substantially during development. The study then focused on Toll/NF-κB inhibition, revealing that IPCs or neuroblasts are important for the effects of lifespan and healthspan extension but in a life stage-dependent manner while some of these effects display sexual dimorphism. Importantly, co-inhibition of Toll/NF-κB pathway in IPCs and neuroblasts increased fly lifespan greater than either cell population, suggesting that independent mechanisms might exist. Toll/NF-κB inhibition in IPCs was also sufficient to enhance survival under various fatal stresses, supporting the additional benefits to fly healthspan. In conclusion, IPCs and neuroblasts are important for [i]Drosophila[/i] NF-κB for controlling lifespan.
* Biomechanical Phenomena
* Brain
* Cell Culture Techniques
* Cell Membrane
* Cellular Senescence
* Endothelial Cells
* Endothelium, Vascular
* Humans
* Microscopy, Atomic Force
* Vascular Endothelial Growth Factor A
|keywords=* Amyloid beta oligomer
* Atomic force microscopy
* Brain endothelial cells
* Nanoindentation
* Nanomechanical properties
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791778
}}
==AGER==


===MeSH Terms===
{{medline-entry
-
|title=Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575929


===Keywords===
|mesh-terms=* Aging
Drosophila; aging; brain; neuron
* Animals
* Antioxidants
* Apoptosis
* Cell Proliferation
* Cholecalciferol
* Down-Regulation
* Galactose
* Male
* Oxidative Stress
* Rats
* Spermatogenesis
* Testis


==Methionine transsulfuration pathway is upregulated in long-lived humans.==
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773724
===Abstract===
}}
Available evidences point to methionine metabolism as a key target to study the molecular adaptive mechanisms underlying differences in longevity. The plasma methionine metabolic profile was determined using a LC-MS/MS platform to systematically define specific phenotypic patterns associated with genotypes of human extreme longevity (centenarians). Our findings demonstrate the presence of a specific plasma profile associated with human longevity characterized by an enhanced transsulfuration pathway and tricarboxylic acid (TCA) cycle intermediates, as well as a reduced content of specific amino acids. Furthermore, our work reveals that centenarians maintain a strongly correlated methionine metabolism, suggesting an improved network integrity, homeostasis and more tightly regulated metabolism. We have discovered a particular methionine signature related to the condition of extreme longevity, allowing the identification of potential mechanisms and biomarkers of healthy aging.
==AGT==


===MeSH Terms===
{{medline-entry
-
|title=SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441382


===Keywords===
Amino acids; Centenarians; Longevity; Methionine cycle; Plasma; TCA Cycle metabolites; Transsulfuration pathway


==Mitochondrial Glutamine Metabolism Determines Senescence Induction After Chemotherapy.==
|keywords=* Aging
===Abstract===
* SQSTM1
Cellular senescence is an important tumor-suppressive mechanism that arrests the cell cycle of damaged cells after diverse stresses. This study aimed to elucidate the role of mitochondrial glutamine (Gln) metabolism in senescence cell-fate decision after DNA damage. β-galactosidase staining was used to determine senescence induction. The mechanistic target of rapamycin (mTOR) activity and p21 expression were examined by western blot. Cell proliferation and clonogenic growth were evaluated. Inhibition of mitochondrial Gln metabolism suppressed DNA damage-induced senescence, whereas increased Gln anaplerosis resulted in a profound induction of senescence. Mechanistically, Gln anaplerosis mediated senescence induction by activating mTOR signaling upon DNA damage. Importantly, enhancing Gln anaplerosis could reduce the emergence of proliferative subpopulations of cancer cells after exposure to non-lethal doses of chemotherapeutic agents. Mitochondrial Gln metabolism is an important regulator of DNA damage-induced senescence, which may be used for developing effective therapeutic approaches.
* autophagy
* oxidative stress
* senescence
* vascular biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469683
}}
==AHR==


===MeSH Terms===
{{medline-entry
-
|title=Indoles from the commensal microbiota act via the [[AHR]] and IL-10 to tune the cellular composition of the colonic epithelium during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817517


===Keywords===
|mesh-terms=* Aging
DNA damage; Senescence; glutamine metabolism; mTOR
* Animals
* Bacteria
* Cell Differentiation
* Epithelial Cells
* Female
* Goblet Cells
* Indoles
* Interleukin-10
* Interleukins
* Male
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Mice, Knockout
* Microbiota
* Mucus
* Receptors, Aryl Hydrocarbon
* Signal Transduction
|keywords=* aging
* goblet cell
* intestinal homeostasis
* mucus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474656
}}
{{medline-entry
|title=Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31795255


==Sleep medication use and incident dementia in a nationally representative sample of older adults in the US.==
|mesh-terms=* Animals
===Abstract===
* Environmental Exposure
Sleep difficulties are common among older adults, and clinical management of sleep difficulties commonly includes sleep medication (pharmacological and non-pharmacological). Our research examines sleep medication use and incident dementia over 8 years using nationally representative data from older adults ages 65 years and older in the United States. We used data collected from the National Health and Aging Trends Study (NHATS), a nationally-representative longitudinal study of Medicare beneficiaries. Routine sleep medication use (pharmacological and non-pharmacological) was defined as use "most nights" or "every night." Participants were screened for dementia with validated instruments that assessed memory, orientation, and executive function. We conduct prospective analyses to examine the relationship between routine sleep medication use and incident dementia using Cox proportional hazards modeling and estimated survival curves. Analyses controlled for age, sex, marital status, education, and chronic conditions. Among respondents at baseline (n = 6373), most participants (21%) were age 70-74 years of age. Participants were 59% female and the sample comprised non-Hispanic White (71%). At baseline, 15% of our study sample reported using sleep medication routinely, which is representative of 4.6 million older adults in the US. Covariate adjusted proportional hazard models revealed that routinely using sleep medication was associated with incident dementia (HR = 1.30, 95%CI: 1.10 to 1.53, p < 0.01). Our study observed, in a nationally representative study of older adults in the US across 8 years of data that 15% of older adults report routinely using sleep medication, yet routine use of sleeping medication was associated with incident dementia across the follow-up interval. Future research may examine behavioral approaches to improving sleep among older adults.
* Extracellular Matrix
* Humans
* Receptors, Aryl Hydrocarbon
* Skin Aging
* Skin Neoplasms
|keywords=* DNA damage
* UV radiation
* extracellular matrix
* extrinsic skin aging
* melanoma
* particulate matter
* pigmentation
* polycyclic aromatic hydrocarbons
* squamous cell carcinoma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928879
}}
==AIP==


===MeSH Terms===
{{medline-entry
-
|title=[Aryl hydrocarbon receptor interacting protein ([[AIP]]) in human dermis during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280328


===Keywords===
Dementia; Gerontology; Sleep medication; Sleep medicine


==Trends in inpatient discharges with drug or alcohol admission diagnoses to a skilled nursing facility among older adults, New York City 2008-2014.==
|keywords=* AIP
===Abstract===
* PCNA
Recent research shows an increase in drug and alcohol-related hospitalizations in the USA, especially among older adults. However, no study examines trends in discharges to a skilled nursing facility (SNF) after a drug or alcohol-related hospitalization. Older adults are more likely to need post-hospital care in a SNF after a hospitalization due to an increased presence of chronic diseases and functional limitations. Therefore, the objective of this study was to estimate trends in drug or alcohol-related hospitalizations with discharge to a SNF among adults age 55 and older. We analyzed data from New York State's Statewide Planning and Research Cooperative System to calculate the number of cannabis, cocaine, opioid, and alcohol-related hospitalizations in New York City that resulted in discharge to a SNF from 2008 to 2014 among adults age 55 and older. Using New York City population estimates modified from US Census Bureau, we calculated age-specific rates per 100,000 adults. Trend tests were estimated using joinpoint regressions to calculate annual percentage change (APC) with 95% confidence intervals (CI) and stratified by adults age 55-64 and adults age 65 and older. During the study period, among adults age 55-64, there were significant increases in cocaine, cannabis, and opioid-related hospitalizations that resulted in discharge to a SNF. For adults ≥ 65 years, there were sharp increases across all substances with larger increases in opioids (APC of 10.66%) compared to adults 55-64 (APC of 6.49%). For both age groups and among the four substances, alcohol-related hospitalizations were the leading cause of discharge to a SNF. We found an increase in hospital discharges to SNFs for patients age 55 and older admitted with alcohol or drug-related diagnoses. Post-acute and long-term care settings should prepare to care for an increase in older patients with substance use disorders by integrating a range of harm reduction interventions into their care settings.
* aging
* fibroblasts
* skin


===MeSH Terms===
}}
-
{{medline-entry
|title=Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32350171


===Keywords===
Geriatrics; Long-term care; Post-acute care; Substance use


==The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin.==
|keywords=* atherogenic index of plasma
===Abstract===
* dyslipidaemia
The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also contribute to skin cancer risk. This study aimed at exploring the role of photoaging, as well as other well-known epidemiological risk factors, in the accumulation of somatic mutations in cancer-free human epidermis. We deeply sequenced 46 genes in normal skin biopsies from 127 healthy donors, from which phenotypic data (including age, pigmentation-related genotype and phenotype) and sun exposure habits were collected. We determined the somatic mutational burden, mutational signatures, clonal selection and frequency of driver mutations in all samples. Our results reveal an exponential accumulation of UV-related somatic mutations with age, matching skin cancer incidence. The increase of mutational burden is in turn modified by an individual's skin phototype. Somatic mutations preferentially accumulated in cutaneous squamous cell carcinoma (cSCC) cancer genes and clonally expanded with age, with distinct mutational processes underpinning different age groups. Our results suggest loss of fidelity in transcription-coupled repair later in life. Our findings reveal that aging is not only associated with an exponential increase in the number of somatic mutations accumulated in normal epidermis, but also with selection and expansion of cancer-associated mutations. Aged, sun-exposed normal skin is thus an extended mosaic of multiple clones with driver mutations, poised for the acquisition of transforming events.
* gerontology
* sex difference
* vitamin D
|full-text-url=https://sci-hub.do/10.3177/jnsv.66.105
}}
{{medline-entry
|title=The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654648


===MeSH Terms===
|mesh-terms=* Aged
-
* Brain
* Cognition
* Connectome
* Diffusion Tensor Imaging
* Executive Function
* Female
* Humans
* Judgment
* Male
* Middle Aged
* Neuropsychological Tests
* Pattern Recognition, Visual
* Spatial Processing
|keywords=* Aging
* Executive function
* Oblique effect
* Perception
* Structural connectivity
* Visuospatial processing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887099
}}
==ALAS1==


===Keywords===
{{medline-entry
Aging; Next-generation sequencing; Skin Phototype; Somatic mutation; UV exposure; carcinogenesis; mutational spectrum; normal epidermis
|title=Heterozygous disruption of [[ALAS1]] in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307066


==Cyst Reduction by Melatonin in a Novel [i]Drosophila[/i] Model of Polycystic Kidney Disease.==
===Abstract===
Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the [i]Bicaudal C[/i] ([i]BicC[/i]) [i]Drosophila[/i] model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the [i]BicC[/i] fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment.


===MeSH Terms===
|keywords=* 5-Aminolevulinate synthase 1 (ALAS1)
-
* 5-Aminolevulinic acid (ALA)
* Aging
* Free heme
* Liver
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108721
}}
==ALB==


===Keywords===
{{medline-entry
Drosophila; longevity; melatonin; oxidative stress; polycystic kidney disease; renal cysts
|title=Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262938


==Ozone-induced changes in oxidative stress parameters in brain regions of adult, middle-age, and senescent Brown Norway rats.==
===Abstract===
A critical part of community based human health risk assessment following chemical exposure is identifying sources of susceptibility. Life stage is one such susceptibility. A prototypic air pollutant, ozone (O ) induces dysfunction of the pulmonary, cardiac, and nervous systems. Long-term exposure may cause oxidative stress (OS). The current study explored age-related and subchronic O -induced changes in OS in brain regions of rats. To build a comprehensive assessment of OS-related effects of O , a tripartite approach was implemented focusing on 1) the production of reactive oxygen species (ROS) [NADPH Quinone oxidoreductase 1, NADH Ubiquinone reductase] 2) antioxidant homeostasis [total antioxidant substances, superoxide dismutase, γ-glutamylcysteine synthetase] and 3) an assessment of oxidative damage [total aconitase and protein carbonyls]. Additionally, a neurobehavioral evaluation of motor activity was compared to these OS measures. Male Brown Norway rats (4, 12, and 24 months of age) were exposed to air or O  (0.25 or 1 ppm) via inhalation for 6 h/day, 2 days per week for 13 weeks. A significant decrease in horizontal motor activity was noted only in 4-month old rats. Results on OS measures in frontal cortex (FC), cerebellum (CB), striatum (STR), and hippocampus (HIP) indicated life stage-related increases in ROS production, small decreases in antioxidant homeostatic mechanisms, a decrease in aconitase activity, and an increase in protein carbonyls. The effects of O  exposure were brain area-specific, with the STR being more sensitive. Regarding life stage, the effects of O  were greater in 4-month-old rats, which correlated with horizontal motor activity. These results indicate that OS may be increased in specific brain regions after subchronic O  exposure, but the interactions between age and exposure along with their consequences on the brain require further investigation.


===MeSH Terms===
|keywords=* M/L ratio
-
* SAA
* aging
* domestic cats
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695597
}}
==ALK==


===Keywords===
{{medline-entry
Aging; Air pollution; Antioxidants; Neurotoxicity; Oxidative stress; Ozone; Protein carbonyls; Susceptibility
|title=Catalog of Lung Cancer Gene Mutations Among Chinese Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850378


==Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma.==
===Abstract===
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death and is the most common type of liver cancer. Due to the current paucity of drugs for HCC therapy there is a pressing need to develop new therapeutic concepts. In recent years, the role of Serum Response Factor (SRF) and its coactivators, Myocardin-Related Transcription Factors A and B (MRTF-A and -B), in HCC formation and progression has received considerable attention. Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. In this article, we describe the key features and the functional role of senescence in light of the development of novel drug targets for HCC therapy with a focus on MRTFs.


===MeSH Terms===
|keywords=* China
-
* aging
* gene mutation
* lung cancer
* pathology
* tobacco smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417348
}}
==ALKBH8==


===Keywords===
{{medline-entry
DLC1; HCC; MRTF; SRF; senescence; senolytics
|title=Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming .
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765888


==Triggering Postural Movements With Virtual Reality Technology in Healthy Young and Older Adults: A Cross-Sectional Validation Study for Early Dementia Screening.==
|mesh-terms=* AlkB Homolog 8, tRNA Methyltransferase
===Abstract===
* Animals
With the ultimate aim of early diagnosis of dementia, a new body balance assessment system with integrated head-mounted display-based virtual reality (VR) has been developed. We hypothesized that people would sway more in anterior-posterior (AP) direction when they were exposed to a VR environment where we intentionally provoked movements in forward and backward directions. A total of 14 healthy older adults (OA) (73.14±4.26 years) and 15 healthy young adults (YA) (24.93±1.49 years) were assessed for group differences in sway behavior. Body sway speed in 22 different conditions with and without VR environments was analyzed. Significant differences and large effect sizes were observed in AP sway under the VR environments (OA with [i]P[/i] < 0.02; effect size> 0.61, YA with [i]P[/i] < 0.003; effect size> 0.72) compared to the baseline condition without the VR environments. In addition, significant differences were found between the two groups in AP sway in all test conditions ([i]P[/i] < 0.01). Our study shows that a VR environment can trigger body sway in an expected direction, which may indicate that it is possible to enhance the sensitivity of balance assessment by integrating immersive VR environments. The result of this study warrants a cross-sectional study in which OA diagnosed with and without dementia are compared on their sway behavior.
* Cells, Cultured
* Cellular Senescence
* Epigenesis, Genetic
* Gene Deletion
* Gene Expression Profiling
* Humans
* Mice
* Mitochondria
* Oxygen Consumption
* Selenocysteine
* Uncoupling Protein 2
|keywords=* Epitranscriptome
* Mitochondria
* Selenium
* Senescence
* Uncoupling protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904832
}}
==ALOX12==


===MeSH Terms===
{{medline-entry
-
|title=Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32265301


===Keywords===
aging; balance assessment; dementia; early diagnosis; head-mounted display (HMD); postural sway; posture; virtual reality


==Reduced erythrocyte lifespan measured by chromium-51 in patients with type 2 diabetes undergoing long-term hemodialysis.==
|keywords=* aging
===Abstract===
* arachidonic acid (AA) (ARA)
A reduced erythrocyte lifespan potentially explains the low hemoglobin A1c values found in hemodialysis patients. However, data supporting this notion in patients with type 2 diabetes is unclear. We evaluated the erythrocyte lifespan in patients with type 2 diabetes undergoing long-term hemodialysis and investigated potential predictors of erythrocyte lifespan. Long-term hemodialysis patients with type 2 diabetes and type 2 diabetes patients without nephropathy (estimated glomerular filtration rate > 60 mL/min/1.73 m  ) were included. The erythrocyte lifespan was measured using chromium-51 ( Cr)-labeled erythrocytes. Blood radiotracer activity was measured six to nine times over a period of 3-5 weeks to determine the erythrocyte lifespan of each patient. Biochemical markers were obtained five times over 16 weeks and associated with the erythrocyte lifespan. Type 2 diabetes patients undergoing hemodialysis (N = 13) had a significantly shorter median erythrocyte lifespan of 49.7 (interquartile range [IQR] = 44.1-58.6) days compared with 64.2 (IQR = 62.6-83.5) days in the control group (N = 10) (P ˂ 0.001) with a difference between medians of 14.5 (95% confidence interval = 8.1-38.8) days. In the hemodialysis group, no association could be detected between the erythrocyte lifespan and markers of hemolysis, level of inflammation, or urea. A reduced erythrocyte lifespan was detected in type 2 diabetes patients undergoing long-term hemodialysis. This may contribute to the reduced hemoglobin A1c values observed in the type 2 diabetic hemodialysis population. An association could not be detected between the erythrocyte lifespan and biochemical markers of hemolysis or inflammation.
* cancer biology
* cell proliferation
* fibroblast
* pancreatic cancer
* stromal cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242692
}}
==ALOX5==


===MeSH Terms===
{{medline-entry
-
|title=Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642348


===Keywords===
|mesh-terms=* Aging
Hemodialysis; chromium-51; erythrocyte lifespan; type 2 diabetes
* Alanine
* Animals
* Arachidonate 5-Lipoxygenase
* Asparagine
* Body Weight
* Female
* Gene Knock-In Techniques
* Leukotrienes
* Linoleic Acid
* Male
* Mice
* Mutation
* PPAR gamma
* Phenylalanine
|keywords=* eicosanoids
* inflammation
* leukotrienes
* lipoxygenase
* resolvins
|full-text-url=https://sci-hub.do/10.1089/ars.2019.7751
}}
==AMH==


==Cell non-autonomous regulation of health and longevity.==
{{medline-entry
===Abstract===
|title=Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.
As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism's ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging from [i]C. elegans[/i] to mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141175


===MeSH Terms===
-


===Keywords===
|keywords=* STRAW
C. elegans; D. melanogaster; aging; genetics; genomics; healthspan; insulin signaling; neuroscience; sensory perception
* adolescent and young adult cancer
* menopausal transition
* premature ovarian insufficiency
* reproductive aging
|full-text-url=https://sci-hub.do/10.1210/clinem/dgaa797
}}
{{medline-entry
|title=Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645159


==Handgrip strength asymmetry is associated with future falls in older Americans.==
===Abstract===
Examining handgrip strength (HGS) asymmetry could extend the utility of handgrip dynamometers for screening future falls. We sought to determine the associations of HGS asymmetry on future falls in older Americans. The analytic sample included 10,446 adults aged at least 65 years from the 2006-2016 waves of the Health and Retirement Study. Falls were self-reported. A handgrip dynamometer measured HGS. The highest HGS on each hand was used for determining HGS asymmetry ratio: (non-dominant HGS/dominant HGS). Those with HGS asymmetry ratio < 1.0 had their ratio inverted to make all HGS asymmetry ratios ≥ 1.0. Participants were categorized into asymmetry groups based on their inverted HGS asymmetry ratio: (1) 0.0-10.0%, (2) 10.1-20.0%, (3) 20.1-30.0%, and (4) > 30.0%. Generalized estimating equations were used for the analyses. Every 0.10 increase in HGS asymmetry ratio was associated with 1.26 (95% confidence interval (CI) 1.07-1.48) greater odds for future falls. Relative to those with HGS asymmetry 0.0-10.0%, participants with HGS asymmetry > 30.0% had 1.15 (CI 1.01-1.33) greater odds for future falls; however, the associations were not significant for those with HGS asymmetry 10.1-20.0% (odds ratio: 1.06; CI 0.98-1.14) and 20.1-30.0% (odds ratio: 1.10; CI 0.99-1.22). Compared to those with HGS asymmetry 0.0-10.0%, participants with HGS asymmetry > 10.0% and > 20.0% had 1.07 (CI 1.01-1.16) and 1.12 (CI 1.02-1.22) greater odds for future falls, respectively. Asymmetric HGS, as a possible biomarker of impaired neuromuscular function, may help predict falls. We recommend that HGS asymmetry be considered in HGS protocols and fall risk assessments.


===MeSH Terms===
|keywords=* Cardiometabolic Risk
-
* HIV
* Menopause
* Reproductive Aging
* Sex
* Women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347076
}}
{{medline-entry
|title=Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285295


===Keywords===
Aging; Functional laterality; Geriatric assessment; Geriatrics; Muscle strength dynamometer


==Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis.==
|keywords=* Aging
===Abstract===
* DNA methylation
Phenotypic and functional plasticity of brain immune cells contribute to brain tissue homeostasis and disease. Immune cell plasticity is profoundly influenced by tissue microenvironment cues and systemic factors. Aging and gut microbiota dysbiosis that reshape brain immune cell plasticity and homeostasis has not been fully delineated. Using Cellular Indexing of Transcriptomes and Epitopes by sequencing (CITE-seq), we analyze compositional and transcriptional changes of the brain immune landscape in response to aging and gut dysbiosis. Discordance between canonical surface-marker-defined immune cell types and their transcriptomes suggest transcriptional plasticity among immune cells. Ly6C  monocytes predominate a pro-inflammatory signature in the aged brain, while innate lymphoid cells (ILCs) shift toward an ILC2-like profile. Aging increases ILC-like cells expressing a T memory stemness (T ) signature, which is reduced through antibiotics-induced gut dysbiosis. Systemic changes due to aging and gut dysbiosis increase propensity for neuroinflammation, providing insights into gut dysbiosis in age-related neurological diseases.
* Epigenetic clock
* Epigenetics
* Infertility
* Methylome
* Ovarian aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244694
}}
{{medline-entry
|title=Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using [[AMH]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270202


===MeSH Terms===
-


===Keywords===
|keywords=* AMH
CITE-seq; CNS; aging; brain; brain immunity; dysbiosis; gut microbiota; single-cell sequencing
* adolescent and young adult cancer
* functional principal components analysis
* ovarian reserve
* reproductive lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329316
}}
{{medline-entry
|title=Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109280


==Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.==
===Abstract===
Carbofuran is a carbamate pesticide, widely used in agricultural practices to increase crop productivity. In mammals, carbofuran is known to cause several untoward effects, such as apoptosis in the hippocampal neuron, oxidative stress, loss of memory and chromosomal anomalies. Most of these effects are implicated with cellular senescence. Therefore, the present study aimed to determine the effect of carbofuran on cellular senescence and biological ageing. Spinster homolog 1 (Spns1) is a transmembrane transporter, regulates autolysosomal biogenesis and plays a role in cellular senescence and survival. Using senescence-associated β-galactosidase staining, we found that carbofuran accelerates the cellular senescence in spns1 mutant zebrafish. The yolk opaqueness, a premature ageing phenotype in zebrafish embryos, was accelerated by carbofuran treatment. In the survival study, carbofuran shortened the life span of spns1 mutant zebrafish. Autophagy is the cellular lysosomal degradation, usually up-regulated in the senescent cells. To know the impact of carbofuran exposure on autophagy progress, we established a double-transgenic zebrafish line, harbouring EGFP-tagged LC3-II and mCherry-tagged Lamp1 on spns1 mutant background, whereas we found, carbofuran exposure synergistically accelerates autolysosome formation with insufficient lysosome-mediated degradation. Our data collectively suggest that carbofuran exposure synergistically accelerates the cellular senescence and affects biological ageing in spns1 defective animals.


===MeSH Terms===
|keywords=* Tehran Lipid and Glucose Study (TLGS)
-
* anti-müllerian hormone (AMH)
* menopause
* reproductive aging
|full-text-url=https://sci-hub.do/10.1210/clinem/dgaa083
}}
{{medline-entry
|title=Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31965189


===Keywords===
carbofuran; life span; senescence; spinster homolog 1; zebrafish


==Rationale and Methodology of The PopulatION HEalth and Eye Disease PRofile in Elderly Singaporeans Study [PIONEER].==
|keywords=* aging
===Abstract===
* female reproductive endocrinology
To describe the rationale, design and methodology of a geographically-representative and population-based study investigating the epidemiology, impact, personal and economic burden of age-related eye diseases, declining visual and other sensory systems in Asians aged >60 years in Singapore.PIONEER (The PopulatION HEalth and Eye Disease PRofilE in Elderly Singaporeans Study) is currently a cross-sectional study targeting 3152 Chinese, Malay and Indian adults who are Singapore citizens or permanent residents aged 60 years and older living across Singapore. The study is intended to be longitudinal, with several waves of data planned to be collected in the future. The sampling frame consisted of 7000 names derived from age, gender and ethnicity-stratified random sampling of individuals >60 years. Selected individuals were invited via letters, home visits, and telephone calls for a clinical assessment at the Singapore Eye Research Institute. Individuals with limited mobility were examined in a custom-designed mobile eye clinic. Questionnaires were subsequently administered at participants' homes by trained interviewers in their preferred language. A total of 3,299 participants (from East, West, North and South Singapore) were approached from December 2017 to November 2019. Of these, 953 (28.5%) were deemed ineligible. Out of 2,346 eligible participants, 904 (38.5%) refused, and 1,442 (61.5%) attended our clinical testing protocol, giving an initial response rate of 61.5%. Of these, 1,170 (81%) were cognitively able to complete the questionnaire assessment. The mean age±SD of our participants was 73.8±8.6 years; n=798 (55.3%) were female; and 828 (57.4%) were of Chinese ethnicity. The findings from this study will allow a deeper understanding of the risk factors and impact of aging in Asian populations, particularly in relation to the visual function and other functional system.
* gonadotropins
* inhibin/activin/follistatin/AMH
* menopause
* ovaries
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067546
}}
{{medline-entry
|title=Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900800


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Anti-Mullerian Hormone
* Antigens, Ly
* Cell Differentiation
* Cell Shape
* Female
* Lewis X Antigen
* Membrane Proteins
* Mice, Inbred C57BL
* Ovary
* Stem Cells
|keywords=* BMP-4
* Multipotent
* Ovary
* Retinoic acid
* Stem cells
|full-text-url=https://sci-hub.do/10.1007/s11626-019-00411-x
}}
{{medline-entry
|title=Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31782794


===Keywords===
|mesh-terms=* Adolescent
aging; epidemiology; eye disease; population-based study; visual function system; visual impairment
* Adult
* Aging
* Anti-Mullerian Hormone
* Child
* Child, Preschool
* Female
* Fertility Preservation
* Humans
* Ovarian Follicle
* Retrospective Studies
* Young Adult
|keywords=* anti-Müllerian hormone
* cancer
* fertility preservation
* ovarian reserve
* ovarian tissue
* primary follicle
* primordial follicle
|full-text-url=https://sci-hub.do/10.1093/humrep/dez215
}}
{{medline-entry
|title=Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31586179


==Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.==
|mesh-terms=* Adult
===Abstract===
* Anti-Mullerian Hormone
Aging impairs the IGF-I signaling of bone marrow mesenchymal stem cells (bmMSCs), but the mechanism is unclear. Here, we found that the ability to auto-phosphorylate IGF-I receptor (IGF-IR) in response to IGF-I was decreased in the bmMSCs of aged donors. Conversely, data showed that decorin (DCN) expression was prominently increased in aged bmMSCs, and that under IGF-I treatment, DCN knockdown in serum-starved aged bmMSCs potentiated their mitogenic activity and IGF-IR auto-phosphorylation, whereas DCN overexpression in serum-starved adult bmMSCs decreased both activities. Co-immunoprecipitation assays suggested that IGF-I and DCN bound to IGF-IR in a competitive manner. Online MethPrimer predicted 4 CpG islands (CGIs) in the introns of [i]DCN[/i] gene. RT-qPCR and bisulfite sequencing showed that dimethyloxalylglycine, an inhibitor of DNA demethylation, increased [i]DCN[/i] mRNA expression and CGI-I methylation in adult bmMSCs, whereas 5-aza-2'-deoxycytidine, a DNA methylation inhibitor, decreased [i]DCN[/i] mRNA expression and CGI-I methylation in aged bmMSCs, and ultimately enhanced the proliferation of serum-starved aged bmMSCs under IGF-I stimulation. Thus, IGF-IR could be the prime target of aging in down-regulating the IGF-I signaling of bmMSCs, where DCN could be a critical mediator.
* Biomarkers
* Body Mass Index
* Cardiovascular Diseases
* Case-Control Studies
* Cross-Sectional Studies
* Female
* Follow-Up Studies
* Humans
* Incidence
* Infertility, Female
* Polycystic Ovary Syndrome
* Prognosis
* United States
|keywords=* anti-mullerian hormone (AMH)
* cardiometabolic health
* cardiovascular risk
* ovarian aging
* ovarian reserve markers
* reproductive aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024739
}}
{{medline-entry
|title=Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31586925


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Anti-Mullerian Hormone
* Female
* Fertility
* Horses
* Ovarian Follicle
* Ovulation
|keywords=* AMH
* Anzahl Follikel
* Ovar
* Pferd
* Ultraschall
* compte folliculaire
* conta dei follicoli
* ecografia
* equine
* equini
* follicle count
* ovaia
* ovaire
* ovary
* reproductive status
* stato riproduttivo
* ultrasonography
* ­Reproduktionsstatus
* échographie
* équin
* état reproducteur
|full-text-url=https://sci-hub.do/10.17236/sat00225
}}
==AMT==


===Keywords===
{{medline-entry
IGF-I; aging; bone marrow mesenchymal stem cell; osteoporosis; small leucine-rich proteoglycan
|title=A multi-method comparison of autobiographical memory impairments amongst younger and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32162531


==[Potentials and limits of aging cohort studies for geriatric psychiatry].==
===Abstract===
The sizeable number of population-based cohort studies of aging in Germany have provided highly valuable contributions for the specification of risk factors and predictors for frequent mental disorders in old age, especially dementia and depression. The results from these cohort studies enable the specification of mechanisms for the development of and preventative interventions for common mental disorders in old age. On the other hand, there is a significant paucity of clinical cohort studies investigating disease trajectories and possible markers for specific individualized interventions of frequent mental disorders in old age. In this article, we report selected key findings from cohort studies of aging and discuss novel approaches for the integration and harmonization of population-based and clinical cohort studies.


===MeSH Terms===
|keywords=* Depression
-
* aging
* episodic memory
* overgeneral
* specificity
|full-text-url=https://sci-hub.do/10.1080/13607863.2020.1729338
}}
==ANGPTL2==


===Keywords===
{{medline-entry
Aging; Disease course; Mental diseases; Panel studies; Risk factors
|title=Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840173


==Divergent Nodes of Non-autonomous UPR  Signaling through Serotonergic and Dopaminergic Neurons.==
|mesh-terms=* Aged
===Abstract===
* Angiopoietin-like Proteins
In multicellular organisms, neurons integrate a diverse array of external cues to affect downstream changes in organismal health. Specifically, activation of the endoplasmic reticulum (ER) unfolded protein response (UPR ) in neurons increases lifespan by preventing age-onset loss of ER proteostasis and driving lipid depletion in a cell non-autonomous manner. The mechanism of this communication is dependent on the release of small clear vesicles from neurons. We find dopaminergic neurons are necessary and sufficient for activation of cell non-autonomous UPR  to drive lipid depletion in peripheral tissues, whereas serotonergic neurons are sufficient to drive protein homeostasis in peripheral tissues. These signaling modalities are unique and independent and together coordinate the beneficial effects of neuronal cell non-autonomous ER stress signaling upon health and longevity.
* Biomarkers
* C-Reactive Protein
* Disease Progression
* Female
* Humans
* Kidney Diseases
* Male
* Middle Aged
* Prognosis
* Prospective Studies
* Renal Dialysis
* Risk Factors
* Survival Rate
|keywords=* aging
* angiopoietin-like protein (ANGPTL) 2
* chronic inflammation
* hemodialysis
* mortality risk
|full-text-url=https://sci-hub.do/10.1093/ndt/gfz236
}}
==ANK3==


===MeSH Terms===
{{medline-entry
-
|title=Age-related atrophy of cortical thickness and genetic effect of [[ANK3]] gene in first episode MDD patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32911427


===Keywords===
UPRER; aging; non-autonomous signaling; stress response


==Risk factors for emergency department revisit in elderly patients with gastrointestinal bleeding secondary to anticoagulant therapy.==
|keywords=* ANK3
===Abstract===
* Aging
To evaluate the frequency of emergency department (ED) revisits among elderly patients with gastrointestinal bleeding secondary to anticoagulant treatment and identify factors associated with an increased risk of ED revisits. A 3-year retrospective observational study was designed, including elderly patients (≥65 years) with atrial fibrillation and undergoing oral anticoagulation therapy who visited the ED for gastrointestinal bleeding. To evaluate the risk factors for 30-day revisit, a multivariate analysis was designed including comorbidities, concomitant treatment, change in anticoagulant treatment and prescription of direct-acting oral anticoagulants. 80 patients were included. At discharge, anticoagulation therapy was modified in 21 (26.2%) patients; and changed from an oral anticoagulant to heparin in 17 (21.2%) patients and to another oral anticoagulant in 4 (5.0%) patients. Anticoagulant treatment was withdrawn in 5 (6.3%) patients at discharge. Eleven (13.7%) patients revisited the ED 30 days after hospital discharge for bleeding episodes. No differences in the frequency of revisit to the ED were observed in the patients who changed their anticoagulant treatment at discharge. In the multivariate analysis, chronic kidney disease was the only factor significantly associated with revisits at 30 days. Elderly patients who experience a first episode of gastrointestinal bleeding have a high risk of revisiting the ED for a bleeding episode, with no particular differences between the types of anticoagulant prescribed at discharge.
* Cortical thickness
* Major depressive disorder
* Neuroimage
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490581
}}
==AOX1==


===MeSH Terms===
{{medline-entry
-
|title=N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32711159


===Keywords===
anticoagulants; drug-related side effects and adverse reactions; emergency medicine; geriatrics; safety


==Effect of Ag on Properties, Microstructure, and Thermostability of Cu-Cr Alloy.==
|keywords=* AMPK
===Abstract===
* MNAM
Cu-Cr-based alloys exhibit excellent electrical conductivity and strength, but their poor thermal stability limits their application in industry. In this paper, Cu-0.2Cr (at. %) and Cu-0.2Cr-0.12Ag (at. %) alloys were prepared to study the effect of Ag on the properties, microstructure, and thermal stability of the Cu-Cr alloy. Microstructure and precipitation were observed by an optical microscope (OM) and a transmission-electron microscope (TEM). After cold-drawing by 99.9% and aging at 450 °C for 2 h, the peak hardness and electric conductivity of the Cu-Cr alloy were 120.3 HV and 99.5% IACS, respectively, and those of the Cu-Cr-Ag alloy were 135.8 HV and 98.3% IACS, respectively. The softening temperature of the Cu-Cr alloy was 500~525 °C, and that of the Cu-Cr-Ag alloy was about 550 °C. The creep strains of the Cu-Cr and Cu-Cr-Ag alloys at 40 MPa and 400 ℃ for 50 h were 0.18% and 0.05%, respectively. Ag elements improved the thermal stability of the Cu-Cr alloy. Recovery and recrystallization occurred before the coarsening of precipitates during the softening process. Ag atoms mainly improved the softening resistance of the alloy by delaying recrystallization, and mainly increased creep resistance by preventing the increase in mobile-dislocation density.
* Ovarian Aging
* ROS
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101131
}}
==AP2B1==


===MeSH Terms===
{{medline-entry
-
|title=Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31860870


===Keywords===
|mesh-terms=* Adaptor Protein Complex beta Subunits
Cu–Cr system alloy; aging process; microstructure; physical properties; thermal stability
* Aging
* Alzheimer Disease
* Animals
* Astrocytes
* Autophagy
* Cellular Senescence
* Dynamin I
* Genes, Neurofibromatosis 1
* Mice
* RNA, Circular
* Rats
* Rats, Sprague-Dawley
|keywords=* aging
* astrocyte
* autophagy
* biological function
* circular RNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949063
}}
==APC==


==Trends in comorbidities among HIV-infected hospital admissions in New York City from 2006-2016.==
{{medline-entry
===Abstract===
|title=Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014.
Due to the advent and success of antiretroviral therapy (ART), the number of people living and aging with HIV has grown substantially. Although PLHIV are experiencing longer life expectancies, this achievement may be undermined by increasing and disproportionate chronic disease burden among PLHIV. This study is a retrospective analysis of adult (≥18 years) inpatient hospital discharges from a large hospital system in the New York City, New York metropolitan area, between January 1st, 2006 and December 31st, 2016. We aimed to investigate 1) changes in the prevalence of Charlson-defined comorbidities among PLHIV hospitalized between 2006 and 2016, and 2) changes in the unadjusted prevalence ratio (PR) of comorbidities in HIV-positive versus HIV-negative admissions over time. Of 898,139 hospital admissions from 2006-2016, 19,039 (2.1%) were HIV-positive. Across all admissions during the study period, the greatest comorbidity disparities between HIV-positive and HIV-negative admissions were mild liver disease (PR=4.9, 95% CI: [4.8,5.1]), moderate or severe liver disease (PR=2.2 [2.0,2.4]), and chronic pulmonary disease (PR=1.8 [1.8,1.8]). The prevalence and relative burden of comorbidities among hospitalized PLHIV is changing over time. Careful monitoring and intensive discharge planning may be effective strategies for addressing the evolving health needs of PLHIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32925952


===MeSH Terms===
|mesh-terms=* Adult
-
* African Americans
* Aged
* Behavior
* Cohort Studies
* Emotions
* European Continental Ancestry Group
* Female
* Hispanic Americans
* Humans
* Longevity
* Male
* Middle Aged
* Socioeconomic Factors
* Survival Analysis
* United States


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489510
HIV; aging with HIV; comorbidities
}}
{{medline-entry
|title=Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32771388


==Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.==
===Abstract===
Frailty is a condition of elderly characterized by increased vulnerability to stressful events. Frail patients are more likely to have adverse events. The purposes of this study were to define frailty in patients aged ≥ 70 years with chronic coronary syndrome (CCS) and to evaluate mortality and prognostic significance of frailty in these patients. We included 99 patients, ≥ 70 years old (mean age 74±5.3 years), with diagnosis of CCS. They were followed-up for up to 12 months. The frailty score was evaluated according to the Canadian Study of Health and Aging (CSHA). All patients were divided as frail or non-frail. The groups were compared for their characteristics and clinical outcomes. Fifty patients were classified as frail, and 49 patients as non-frail. The 12-month Major Adverse Cardiac Events (MACE) rate was 69.4% in frail patients and 20% in non-frail patients. Frailty increases the risk for MACE as much as 3.48 times. Two patients died in the non-frail group and 11 patients died in the frail group. Frailty increases the risk for death as much as 6.05 times. When we compared the aforementioned risk factors by multivariate analysis, higher CSHA frailty score was associated with increased MACE and death (relative risk [RR] = 22.94, 95% confidence interval [CI] 3.33-158.19, P=0.001, for MACE; RR = 7.41, 95% CI 1.44-38.03, P=0.016, for death). Being a frail elderly CCS patient is associated with worse outcomes. Therefore, frailty score should be evaluated for elderly CCS patients as a prognostic marker.


===MeSH Terms===
|keywords=* Compliance
-
* Senescence
* Stem Cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672319
}}
{{medline-entry
|title=Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32651719


===Keywords===
|mesh-terms=* Female
Aging; Canada; Confidence Intervals; Death; Frail Elderly; Frailty; Heart; Multivariate Analysis; Prognosis; Risk Factors
* Global Burden of Disease
* Global Health
* Humans
* Iran
* Life Expectancy
* Male
* Musculoskeletal Diseases
* Quality-Adjusted Life Years
|keywords=* Burden
* DALY
* Decomposition
* Global burden of diseases
* Iran
* Musculoskeletal diseases
|full-text-url=https://sci-hub.do/10.1007/s11657-020-00767-8
}}
{{medline-entry
|title=Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831549


==Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders.==
|mesh-terms=* Accidental Falls
===Abstract===
* Aged
Mitochondria are the primary source of energy production in the brain thereby supporting most of its activity. However, mitochondria become inefficient and dysfunctional with age and to a greater extent in neurological disorders. Thus, mitochondria represent an emerging drug target for many age-associated neurological disorders. This review summarizes recent advances (covering from 2010 to May 2020) in the use of natural products from plant, animal, and microbial sources as potential neuroprotective agents to restore mitochondrial function. Natural products from diverse classes of chemical structures are discussed and organized according to their mechanism of action on mitochondria in terms of modulation of biogenesis, dynamics, bioenergetics, calcium homeostasis, and membrane potential, as well as inhibition of the oxytosis/ferroptosis pathway. This analysis emphasizes the significant value of natural products for mitochondrial pharmacology as well as the opportunities and challenges for the discovery and development of future neurotherapeutics.
* Aged, 80 and over
* Female
* Geriatrics
* Health Policy
* Health Services Needs and Demand
* Humans
* Japan
* Male
* Mortality
* Public Health
|keywords=* adult intensive & critical care
* epidemiology
* geriatric medicine
* health & safety
* health policy
* public health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924807
}}
{{medline-entry
|title=Stroke Mortality Rates and Trends in Romania, 1994-2017.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624036


===MeSH Terms===
|mesh-terms=* Adult
-
* Age Distribution
* Aged
* Aged, 80 and over
* Cause of Death
* Female
* Humans
* Life Expectancy
* Male
* Middle Aged
* Prognosis
* Registries
* Risk Assessment
* Risk Factors
* Romania
* Sex Distribution
* Stroke
* Time Factors
|keywords=* Mortality
* age-standardized mortality rates
* life expectancy
* stroke
|full-text-url=https://sci-hub.do/10.1016/j.jstrokecerebrovasdis.2019.104431
}}
{{medline-entry
|title=A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31449852


===Keywords===
|mesh-terms=* Accelerometry
Natural products; aging; drug discovery; mitochondrial dysfunction; neurological disorders; neuropharmacology; oxytosis/ferroptosis
* Adult
* Aged
* Aging
* Electroencephalography
* Evoked Potentials
* Exercise Test
* Female
* Gait
* Humans
* Male
* Middle Aged
* Multitasking Behavior
* Reaction Time
* Walking
|keywords=* Dual task
* EEG
* Gait cycle
* Gait related potentials (GRP)
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110709
}}
==APOC3==


==Forever young: the key to rejuvenation during gametogenesis.==
{{medline-entry
===Abstract===
|title=Positional Obstructive Sleep Apnea Syndrome in Elderly Patients.
Cell aging is the result of deteriorating competence in maintaining cellular homeostasis and quality control. Certain cell types are able to rejuvenate through asymmetric cell division by excluding aging factors, including damaged cellular compartments and extrachromosomal rDNA circles, from entering the daughter cell. Recent findings from the budding yeast S. cerevisiae have shown that gametogenesis represents another type of cellular rejuvenation. Gametes, whether produced by an old or a young mother cell, are granted a renewed replicative lifespan through the formation of a fifth nuclear compartment that sequesters the harmful senescence factors accumulated by the mother. Here, we describe the importance and mechanism of cellular remodeling at the nuclear envelope mediated by ESCRT-III and the LEM-domain proteins, with a focus on nuclear pore biogenesis and chromatin interaction during gamete rejuvenation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32050596


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Humans
* Middle Aged
* Polysomnography
* Posture
* Prospective Studies
* Sleep Apnea, Obstructive
* Supine Position
* Young Adult
|keywords=* aging effects
* obstructive sleep apnea
* polysomnography
* positional sleep apnea
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042812
}}
==APOE==


===Keywords===
{{medline-entry
ESCRT-III; LEM-domain; Meiosis; Nuclear pore complex; Replicative lifespan
|title=Polygenic risk score of longevity predicts longer survival across an age-continuum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216869


==Electronic Medication Management System Introduction and Deprescribing Practice in Post-Acute Care.==
===Abstract===
To determine the effect of introducing an electronic medication management system (EMMS) on deprescribing practice in a post-acute hospital setting. This study used a before-after study design. This study examined the admission and discharge medications prescribed to patients admitted to an Australian post-acute hospital before and after the introduction of an EMMS. Data were collected over a 1-month period before and after the introduction of an EMMS and included summary measures of drug burden including Potentially Inappropriate Medications and the Drug Burden Index. We calculated and compared admission and discharge medication prescription as well as change in medication use before and after the introduction of an EMMS. Medication prescription data were available for 121 people before and 107 people after EMMS introduction. In both phases, when compared with admission, those discharged were prescribed fewer medications (mean reduction pre-EMMS = 2.9, P < .001, post-EMMS = 2.6, P < .001), fewer Potentially Inappropriate Medications (mean reduction pre-EMMS = 0.4, P < .001, post-EMMS = 0.6, P < .001) and had lower Drug Burden Index (mean reduction pre-EMMS = 0.1, P < .001, post-EMMS = 0.2, P < .001). The degree of reduction in each measure was similar before and after EMMS introduction. The introduction of an EMMS did not affect deprescribing practice in a post-acute hospital setting. Future work is required to explore the potential for clinical decision support within an EMMS to further improve the safety and effectiveness of deprescribing within post-acute care.


===MeSH Terms===
|keywords=* centenarians
-
* cognitive health
* genetics
* healthy aging
* longevity
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa289
}}
{{medline-entry
|title=Association Between [[APOE]] Alleles and Change of Neuropsychological Tests in the Long Life Family Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216038


===Keywords===
Deprescribing; electronic prescribing; geriatrics; polypharmacy; potentially inappropriate medication


==Are Positive Childhood Experiences Linked to Better Cognitive Functioning in Later Life?: Examining the Role of Life Course Pathways.==
|keywords=* APOE
===Abstract===
* cognition
We examine whether childhood family well-being is associated with cognitive functioning and to what extent the association between the family context and cognitive functioning is explained by adulthood resources.  Data are drawn from the National Social Life, Health, and Aging Project Wave 3 (2015/2016; [i]N[/i] = 3361). We measured cognitive functioning using the Montreal Cognitive Assessment. Childhood family factors included family-life happiness, family structure, and family socioeconomic status. Education, social connectedness, self-mastery, and self-rated health were assessed as adulthood resources.  Respondents who grew up in a happy family had significantly higher levels of cognitive functioning. The formal mediation test suggests that a happy family life during childhood has a positive association with later cognition, in part, by enhancing self-mastery in adulthood.   Our findings provide evidence that positive childhood experiences are linked to later life cognition. The sense of control people have over their life circumstances is one potential pathway explaining this association.
* longevity
* longitudinal studies
|full-text-url=https://sci-hub.do/10.3233/JAD-201113
}}
{{medline-entry
|title=The [[APOE]] gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33215813


===MeSH Terms===
-


===Keywords===
|keywords=* Alzheimer's disease
National Social Life, Health and Aging Project; childhood happiness; cognitive function; cumulative advantage; self-mastery
* aging
* air pollution
* apolipoprotein E
* chromosome 19q13
|full-text-url=https://sci-hub.do/10.1002/alz.12230
}}
{{medline-entry
|title=Homozygosity in the [i][[APOE]][/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33178131


==Reduced pericyte and tight junction coverage in old diabetic rats are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction.==
===Abstract===
Diabetes mellitus (DM) is one of the primary pathological factors that contributes to aging-related cognitive impairments, but the underlying mechanisms remain unclear. We recently reported that old DM rats exhibited impaired myogenic responses of the cerebral arteries and arterioles, poor cerebral blood flow autoregulation, enhanced blood-brain barrier (BBB) leakage, and cognitive impairments. These changes were associated with diminished vascular smooth muscle cell contractile capability linked to elevated reactive oxygen species (ROS) and reduced ATP production. The present study, using a non-obese T2DN DM rat, isolated parenchymal arterioles (PAs), and cultured cerebral microvascular pericytes, examined whether cerebrovascular pericyte in DM is damaged and whether pericyte dysfunction may play a role in the regulation of cerebral hemodynamics and BBB integrity. We found that ROS and mitochondrial superoxide production were elevated in PAs isolated from old DM rats and in high glucose (HG)-treated alpha-smooth muscle actin positive pericytes. HG-treated pericytes displayed decreased contractile capability in association with diminished mitochondrial respiration and ATP production. Additionally, the expression of advanced glycation end products, transforming growth factor-beta, vascular endothelial growth factor, and fibronectin were enhanced, but claudin 5 and integrin β1 was reduced in the brain of old DM rats and HG-treated pericytes. Further, endothelial tight junction and pericyte coverage on microvessels were reduced in the cortex of old DM rats. These results demonstrate our previous findings that the impaired cerebral hemodynamics and BBB leakage and cognitive impairments in the same old DM model are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction.


===MeSH Terms===
|keywords=* APOE E3
-
* Chinese
* aging
* depressive symptom
* schizophrenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593819
}}
{{medline-entry
|title=Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088920


===Keywords===
Diabetes mellitus; aging; blood-brain barrier; cerebral vascular pericytes; oxidative stress


==Age range implications of rats over Strongyloides venezuelensis infection.==
|keywords=* Cognition
===Abstract===
* ageing
To evaluate the dynamics of S. venezuelensis infection in Wistar rats of different age ranges. Thirty-five (n = 35, 7 per group) male Wistar rats were distributed according to age into five groups: 2, 3, 6, 12 and 18 months old (mo). The rats were infected by S. venezuelensis and eggs per gram of feces (EPG) were measured at 3, 9, 15 and 21 days post-infection (dpi). All animals were killed at 21 dpi, thymus, lungs and small intestines were removed, and relative weight calculated. The adult worms recovered from the small intestines and blood cells were counted. Rats in advanced age presented higher parasite oviposition at 9 dpi and posterior reduction of EPG, while young rats still showed higher oviposition at 15 dpi and 21 dpi. At 12 and 18 mo, the rats had greater number of adult worms, which with low fecundity, eosinophilia and least concentration of monocytes. The fecundity of worms was more expressive in young rats. A strong correlation was observed between age and EPG at 9 dpi (R = 0.72, p < 0.0001), at 15 (R = -0.66, p < 0.0001) and at 21 dpi (R = -0.65, p < 0.0001), as well as age and numbers of worms at 21 dpi (R = 0.74, p < 0.0001). The relative weight of the thymus, lungs and small intestines were higher in rats at 2 and 3 mo in comparison to the older groups of rats. Aging process interfered on host-parasite relationship and changed the dynamics of infection of S. venezuelensis in Wistar rats.
* apolipoprotein E
* brain
* lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545750
}}
{{medline-entry
|title=Cardiovascular risk factors and [[APOE]]-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070365


===MeSH Terms===
-


===Keywords===
|keywords=* APOE
Aging; Parasitic disease; Strongyloidiasis
* BMI
* RRID:SCR_001398
* RRID:SCR_002403
* RRID:SCR_002823
* RRID:SCR_002865
* RRID:SCR_007037
* aging
* diffusion tensor imaging
* hypertension
* memory
* path modeling
|full-text-url=https://sci-hub.do/10.1002/jnr.24734
}}
{{medline-entry
|title=[[APOE]] [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999914


==Issues Associated With the Management and Governance of Sensor Data and Information to Assist Aging in Place: Focus Group Study With Health Care Professionals.==
===Abstract===
Smart home and telemonitoring technologies have often been suggested to assist health care workers in supporting older people to age in place. However, there is limited research examining diverse information needs of different groups of health care workers and their access to appropriate information technologies. The aim of this study was to investigate the issues associated with using technologies that connect older people to their health care providers to support aging in place and enhance older people's health and well-being. Seven focus group discussions were conducted comprising 44 health care professionals who provided clinic-based or in-home services to community-dwelling older people. Participants were asked about their information needs and how technology could help them support older people to age in place. The recordings of the sessions were transcribed and thematically analyzed. The perspectives varied between the respondents who worked in primary care clinics and those who worked in community-based services. Three overarching themes were identified. The first theme was "access to technology and systems," which examined the different levels of technology in use and the problems that various groups of health care professionals had in accessing information about their patients. Primary care professionals had access to good internal information systems but they experienced poor integration with other health care providers. The community-based teams had poor access to technology. The second theme was "collecting and sharing of information," which focused on how technology might be used to provide them with more information about their patients. Primary care teams were interested in telemonitoring for specific clinical indicators but they wanted the information to be preprocessed. Community-based teams were more concerned about gaining information on the patients' social environment. The third theme was that all respondents identified similar "barriers to uptake": cost and funding issues, usability of systems by older people, and information security and privacy concerns. The participants perceived the potential benefits of technologies, but they were concerned that the information they received should be preprocessed and integrated with current information systems and tailored to the older people's unique and changing situations. Several management and governance issues were identified, which needed to be resolved to enable the widespread integration of these technologies into the health care system. The disconnected nature of the current information architecture means that there is no clear way for sensor data from telemonitoring and smart home devices to be integrated with other patient information. Furthermore, cost, privacy, security, and usability barriers also need to be resolved. This study highlights the importance and the complexity of management and governance of systems to collect and disseminate such information. Further research into the requirements of all stakeholder groups and how the information can be processed and disseminated is required.


===MeSH Terms===
|keywords=* APOE ε4 differences
-
* brain aging
* dementia
* neuroimaging
* racial/ethnic differences
* resting‐state functional connectivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508460
}}
{{medline-entry
|title=Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32886741


===Keywords===
aging; aging in place; elderly health; home monitoring technology; information governance; information management; older people; smart home; support network


==IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging.==
|keywords=* Cognitive aging
===Abstract===
* Epidemiology
CD4 Foxp3 T  maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3  cells altered their function and resulted in increased fungal burden and immunopathology during oral [i]Candida albicans[/i] (CA) challenge. Excessive inflammation due to the absence of MyD88 in T  coincided with a reduction of the unique population of IL-17A expressing Foxp3  cells (T 17) and an increase in dysfunctional IFN-γ /Foxp3  cells (T IFN-γ) in infected mice. Failure of MyD88  T  to regulate effector CD4  T cell functions correlated with heightened levels of IFN-γ in CD4  T cells, as well as increased infiltration of inflammatory monocytes and neutrophils in oral mucosa [i]in vivo[/i]. Mechanistically, IL-1β/MyD88 signaling was required for the activation of IRAK-4, Akt, and mTOR, which led to the induction and proliferation of T 17 cells. In the absence of IL-1 receptor signaling, T 17 cells were reduced, but IL-6-driven expansion of T IFN-γ cells was increased. This mechanism was physiologically relevant during [i]Candida[/i] infection in aged mice, as they exhibited IL-1 receptor/MyD88 defect in Foxp3  cells, loss of p-mTOR T 17 cells and reduced levels of IL-1β in oral mucosa, which coincided with persistent tongue inflammation. Concurrent with T  dysfunction, aging was associated with increased CD4  T cell hyperactivation and heightened levels of IL-6 in mice and humans in oral mucosa [i]in vivo[/i]. Taken together, our data identify IL-1β/MyD88/T  axis as a new component that modulates inflammatory responses in oral mucosa. Also, dysregulation of this axis in an aging immune system may skew host defense towards an immunopathological response in mucosal compartments.
* Olfactory
* Olfactory impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662159
}}
{{medline-entry
|title=When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of [[APOE]] ε2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32835364


===MeSH Terms===
-


===Keywords===
|keywords=*
Candida; Foxp3; IL-1β; Treg; Treg17; aging; fungal infection; senescence
          APOE
       
* Age beliefs
* Cognition
* Gene
* Health and Retirement Study
* Self-perceptions of aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489069
}}
{{medline-entry
|title=Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817639


==High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging.==
|mesh-terms=* Adult
===Abstract===
* Aged
Adult neural stem cells (NSC) serve as a reservoir for brain plasticity and origin for certain gliomas. Lineage tracing and genomic approaches have portrayed complex underlying heterogeneity within the major anatomical location for NSC, the subventricular zone (SVZ). To gain a comprehensive profile of NSC heterogeneity, we utilized a well-validated stem/progenitor-specific reporter transgene in concert with single-cell RNA sequencing to achieve unbiased analysis of SVZ cells from infancy to advanced age. The magnitude and high specificity of the resulting transcriptional datasets allow precise identification of the varied cell types embedded in the SVZ including specialized parenchymal cells (neurons, glia, microglia) and noncentral nervous system cells (endothelial, immune). Initial mining of the data delineates four quiescent NSC and three progenitor-cell subpopulations formed in a linear progression. Further evidence indicates that distinct stem and progenitor populations reside in different regions of the SVZ. As stem/progenitor populations progress from neonatal to advanced age, they acquire a deficiency in transition from quiescence to proliferation. Further data mining identifies stage-specific biological processes, transcription factor networks, and cell-surface markers for investigation of cellular identities, lineage relationships, and key regulatory pathways in adult NSC maintenance and neurogenesis.
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Apolipoprotein E4
* Biomarkers
* Case-Control Studies
* Cohort Studies
* Female
* Genotype
* Humans
* Male
* Middle Aged


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446786
-
}}
{{medline-entry
|title=Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32767997


===Keywords===
aging; neural stem cell; single-cell RNA sequencing; subventricular zone; transcriptome


==MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.==
|keywords=* Aging
===Abstract===
* Alzheimer’s disease
Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that MYSM1 is a key suppressor of aging and aging-related pathologies. MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, MYSM1 deficiency facilitates the aging process and reduces lifespan, whereas MYSM1 over-expression attenuates the aging process and increases lifespan in mice. The functional role of MYSM1 is demonstrated in suppressing the aging process and prolonging lifespan. MYSM1 is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging-associated diseases.
* Dementia
* Dementia prevention
* Modifiable risk factors
* Population attributable fraction
* Public health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414752
}}
{{medline-entry
|title=Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32740887


===MeSH Terms===
-


===Keywords===
|keywords=* Biomarkers
DNA repair; Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1); aging; senescence; senescence‐associated secretory phenotype (SASP)
* Brain aging
* Cognitive aging
* Machine learning
|full-text-url=https://sci-hub.do/10.1007/s11682-020-00325-3
}}
{{medline-entry
|title=Effects of an [[APOE]] Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32694990


==A Single-Cell Transcriptomic Atlas of Human Skin Aging.==
===Abstract===
Skin undergoes constant self-renewal, and its functional decline is a visible consequence of aging. Understanding human skin aging requires in-depth knowledge of the molecular and functional properties of various skin cell types. We performed single-cell RNA sequencing of human eyelid skin from healthy individuals across different ages and identified eleven canonical cell types, as well as six subpopulations of basal cells. Further analysis revealed progressive accumulation of photoaging-related changes and increased chronic inflammation with age. Transcriptional factors involved in the developmental process underwent early-onset decline during aging. Furthermore, inhibition of key transcription factors HES1 in fibroblasts and KLF6 in keratinocytes not only compromised cell proliferation, but also increased inflammation and cellular senescence during aging. Lastly, we found that genetic activation of HES1 or pharmacological treatment with quercetin alleviated cellular senescence of dermal fibroblasts. These findings provide a single-cell molecular framework of human skin aging, providing a rich resource for developing therapeutic strategies against aging-related skin disorders.


===MeSH Terms===
|keywords=* APOE promoter
-
* aging
* brain connectome
* fronto-parietal network
* working memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338603
}}
{{medline-entry
|title=The relationship of parental longevity with the aging brain-results from UK Biobank.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671621


===Keywords===
HES1; KLF6; aging; fibroblast; keratinocyte; quercetin; senescence; single-cell RNA sequencing; skin


==Senescence in Pulmonary Fibrosis: Between Aging and Exposure.==
|keywords=* Aging
===Abstract===
* Brain structure
To date, chronic pulmonary pathologies represent the third leading cause of death in the elderly population. Evidence-based projections suggest that >65 (years old) individuals will account for approximately a quarter of the world population before the turn of the century. Genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication, are described as the nine "hallmarks" that govern cellular fitness. Any deviation from the normal pattern initiates a complex cascade of events culminating to a disease state. This blueprint, originally employed to describe aberrant changes in cancer cells, can be also used to describe aging and fibrosis. Pulmonary fibrosis (PF) is the result of a progressive decline in injury resolution processes stemming from endogenous (physiological decline or somatic mutations) or exogenous stress. Environmental, dietary or occupational exposure accelerates the pathogenesis of a senescent phenotype based on (1) window of exposure; (2) dose, duration, recurrence; and (3) cells type being targeted. As the lung ages, the threshold to generate an irreversibly senescent phenotype is lowered. However, we do not have sufficient knowledge to make accurate predictions. In this review, we provide an assessment of the literature that interrogates lung epithelial, mesenchymal, and immune senescence at the intersection of aging, environmental exposure and pulmonary fibrosis.
* DTI
* MRI
* Neuroimaging
* Parental longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525531
}}
{{medline-entry
|title=Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32610143


===MeSH Terms===
-


===Keywords===
|keywords=* Alzheimer’s disease
aging; epithelial cells; immune-senescence; inflamm-aging; lung fibrosis; mesenchymal senescence; senescence
* aging
* microglia
* neurodegenerative diseases
* neuroinflammation
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422733
}}
{{medline-entry
|title=Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32474467


==GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly.==
===Abstract===
With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause of death in the last 20 years. Cognitive complaint is considered a predictor for cognitive and functional decline, incident mild cognitive impairment, and incident dementia. The GERO cohort is the Chilean core clinical project of the Geroscience Center for Brain Health and Metabolism (GERO). The objective of the GERO cohort is to analyze the rate of functional decline and progression to clinical dementia and their associated risk factors in a community-dwelling elderly with subjective cognitive complaint, through a population-based study. We also aim to undertake clinical research on brain ageing and dementia disorders, to create data and biobanks with the appropriate infrastructure to conduct other studies and facilitate to the national and international scientific community access to the data and samples for research. The GERO cohort aims the recruitment of 300 elderly subjects (> 70 years) from Santiago (Chile), following them up for at least 3 years. Eligible people are adults not diagnosed with dementia with subjective cognitive complaint, which are reported either by the participant, a proxy or both. Participants are identified through a household census. The protocol for evaluation is based on a multidimensional approach including socio-demographic, biomedical, psychosocial, neuropsychological, neuropsychiatric and motor assessments. Neuroimaging, blood and stool samples are also obtained. This multidimensional evaluation is carried out in a baseline and 2 follow-ups assessments, at 18 and 36 months. In addition, in months 6, 12, 24, and 30, a telephone interview is performed in order to keep contact with the participants and to assess general well-being. Our work will allow us to determine multidimensional risks factors associated with functional decline and conversion to dementia in elderly with subjective cognitive complain. The aim of our GERO group is to establish the capacity to foster cutting edge and multidisciplinary research on aging in Chile including basic and clinical research. NCT04265482 in ClinicalTrials.gov. Registration Date: February 11, 2020. Retrospectively Registered.


===MeSH Terms===
|keywords=* APOEɛ4
-
* Aging
* Alzheimer’s disease
* gender
* lipid
species


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369125
Alzheimer; Cognitive aging; Dementia; Functional decline; Geroscience; Subjective cognitive complaint
}}
{{medline-entry
|title=Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416384


==Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination.==
|mesh-terms=* Age Factors
===Abstract===
* Aged
Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to vaccination. Among the several factors involved, in addition to increased frailty and high-risk conditions, the age-associated decrease in cellular and humoral immune responses plays a relevant role. This is in large part due to inflammaging, the chronic low-grade inflammatory status of the elderly, associated with intrinsic inflammation of the immune cells and decreased immune function. Aging is usually associated with reduced influenza virus-specific and influenza vaccine-specific antibody responses but some elderly individuals with higher pre-exposure antibody titers, due to a previous infection or vaccination, have less probability to get infected. Examples of this exception are the elderly individuals infected during the 2009 pandemic season who made antibodies with broader epitope recognition and higher avidity than those made by younger individuals. Several studies have allowed the identification of B cell intrinsic defects accounting for sub-optimal antibody responses of elderly individuals. These defects include 1) reduced class switch recombination, responsible for the generation of a secondary response of class switched antibodies, 2) reduced de novo somatic hypermutation of the antibody variable region, 3) reduced binding and neutralization capacity, as well as binding specificity, of the secreted antibodies, 4) increased epigenetic modifications that are associated with lower antibody responses, 5) increased frequencies of inflammatory B cell subsets, and 6) shorter telomeres. Although influenza vaccination represents the most effective way to prevent influenza infection, vaccines with greater immunogenicity are needed to improve the response of elderly individuals. Recent advances in technology have made possible a broad approach to better understand the age-associated changes in immune cells, needed to design tailored vaccines and effective therapeutic strategies that will be able to improve the immune response of vulnerable individuals.
* Aged, 80 and over
* Apolipoproteins E
* Biomarkers
* Cognition
* Databases, Factual
* Female
* Genotype
* Hippocampus
* Humans
* Linear Models
* Male
* Middle Aged
* Neuroimaging
* Organ Size
* Parenchymal Tissue
* Reference Values
* Sex Factors
|keywords=* Alzheimer’s disease
* Apolipoprotein E ϵ4
* Atrophy
* Brain
* Healthy aging
* Hippocampal parenchymal fraction
* Hippocampal volumetric integrity
* Hippocampus
* MRI
* Mild cognitive impairment
* Neurodegeneration
* Sex
|full-text-url=https://sci-hub.do/10.1016/j.pscychresns.2020.111107
}}
{{medline-entry
|title=Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32380778


===MeSH Terms===
-


===Keywords===
|keywords=* Cilento Region
Aging; Antibodies; B cells; Influenza infection; Influenza vaccination
* cognitive health
* lifestyle
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279440
}}
{{medline-entry
|title=Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32342099


==The regulatory framework of developmentally programmed cell death in floral organs: A review.==
===Abstract===
Developmentally programmed cell death (dPCD) is a tightly controlled biological process. In recent years, vital roles of dPCD on regulating floral organ growth and development have been reported. It is well known that flower is an essential organ for reproduction and a turning point of plants' life cycle. Hence, uncovering the complex molecular networks which regulates dPCD processes in floral organs is utmost important. So far, our understanding of dPCD on floral organ growth and development is just starting. Herein, we summarize the important factors that involved in the tapetal degeneration, pollen tube rupture, receptive synergid cell death, nucellar degradation, and antipodal cell degradation. Meanwhile, the known factors that involved in transmitting tract formation and self-incompatibility-induced PCD were also introduced. Furthermore, the genes that associated with anther dehiscence and petal senescence and abscission were reviewed as well. The functions of various types of factors involved in floral dPCD processes are highlighted principally. The regulatory panorama described here can provide us some insights about flower-specific dPCD process.


===MeSH Terms===
|keywords=* Aging
-
* Alzheimer’s disease
* Apolipoprotein E
* Cognition
* Cognitive frailty
* Frailty
* Male
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa105
}}
{{medline-entry
|title=CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32305782


===Keywords===
|mesh-terms=* Aged
Floral organ; Programmed cell death; Regulatory network; Senescence; Transcriptional factor
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Biomarkers
* Cerebrovascular Disorders
* Cognitive Dysfunction
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Peptide Fragments
* White Matter
* tau Proteins
|keywords=* Alzheimer's disease
* Amyloid
* Cerebrospinal fluid
* Tau
* Vascular disease
* White matter hyperintensities
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.008
}}
{{medline-entry
|title=Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310160


==Positivity in Younger and in Older Age: Associations With Future Time Perspective and Socioemotional Functioning.==
===Abstract===
Aging has been associated with a motivational shift to positive over negative information (i.e., positivity effect), which is often explained by a limited future time perspective (FTP) within the framework of socioemotional selectivity theory (SST). However, whether a limited FTP functions similarly in younger and older adults, and whether inter-individual differences in socioemotional functioning are similarly associated with preference for positive information (i.e., positivity) is still not clear. We investigated younger (20-35 years, [i]N[/i] = 73) and older (60-75 years, [i]N[/i] = 56) adults' gaze preferences on pairs of happy, angry, sad, and neutral faces using an eye-tracking system. We additionally assessed several parameters potentially underlying inter-individual differences in emotion processing such as FTP, stress, cognitive functioning, social support, emotion regulation, and well-being. While we found no age-related differences in positivity when the entire trial duration was considered, older adults showed longer fixations on the more positive face in later stages of processing (i.e., [i]positivity shifts[/i]). This allocation of resources toward more positive stimuli might serve an emotion regulatory purpose and seems consistent with the SST. However, our findings suggest that age moderates the relationship between FTP and positivity shifts, such that the relationship between FTP and positivity preferences was negative in older, and positive in younger adults, potentially stemming from an age-related differential meaning of the FTP construct across age. Furthermore, our exploratory analyses showed that along with the age and FTP interaction, lower levels of worry also played a significant role in positivity shifts. We conclude that positivity effects cannot be solely explained by aging, or the associated reduced FTP [i]per se[/i], but is rather determined by a complex interplay of psychosocial and emotional features.


===MeSH Terms===
|keywords=* Aging
-
* Alzheimer’s disease
* blood pressure
* cerebrovascular circulation
* neuroimaging
* obesity
|full-text-url=https://sci-hub.do/10.3233/JAD-190360
}}
{{medline-entry
|title=Alzheimer's Risk Factors Age, [[APOE]] Genotype, and Sex Drive Distinct Molecular Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32199103


===Keywords===
|mesh-terms=* Adaptor Proteins, Signal Transducing
aging; future time perspective; positivity bias; positivity effect; socioemotional functioning; socioemotional selectivity theory; well-being; worry
* Age Factors
* Aging
* Alzheimer Disease
* Animals
* Apolipoprotein E2
* Apolipoprotein E3
* Apolipoprotein E4
* Apolipoproteins E
* Brain
* Female
* Gene Expression
* Gene Expression Profiling
* Gene Regulatory Networks
* Genotype
* Humans
* Male
* Membrane Glycoproteins
* Membrane Proteins
* Metabolome
* Mice
* Mice, Transgenic
* Protective Factors
* Receptors, Immunologic
* Risk Factors
* Serpins
* Sex Factors
* Unfolded Protein Response
|keywords=* APOE
* Alzheimer’s disease
* Serpina3
* age
* extracellular vesicles
* inflammation
* lipid metabolism
* metabolomics
* sex
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388065
}}
{{medline-entry
|title=Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32169357


==Cancer Risk in the Heart Failure Population: Epidemiology, Mechanisms, and Clinical Implications.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
Along with population aging, the incidence of both heart failure (HF) and cancer is increasing. However, little is known about new-onset cancer in HF patients. This review aims at showing recent discoveries concerning this subset of patients. Not only cancer and HF share similar risk factors but also HF itself can stimulate cancer development. Some cytokines produced by the failing heart induce mild inflammation promoting carcinogenesis, as it has been recently suggested by an experimental model of HF in mice. The incidence of new-onset cancer is higher in HF patients compared to the general population, and it significantly worsens their prognosis. Moreover, the management of HF patients developing new-onset cancer is challenging, especially due to the limited therapeutic options for patients affected by both cancer and HF and the higher risk of cardiotoxicity from anticancer drugs.
* Amyloidogenic Proteins
* Apolipoproteins E
* Brain
* Cognition
* Cohort Studies
* Female
* Follow-Up Studies
* Humans
* Magnetic Resonance Imaging
* Male
* Neuroimaging
* Organ Size
* Personality
* Positron-Emission Tomography
|keywords=* Amyloid load
* Cognitive aging
* Cohort studies
* Personality
* Structural MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.004
}}
{{medline-entry
|title=Physical Activity as Moderator of the Association Between [[APOE]] and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32110803


===MeSH Terms===
-


===Keywords===
|keywords=* Gene–environment interaction
Aging; Cancer; Cardio-oncology; Heart failure; Pathophysiology; Risk factors
* InCHIANTI
* Longitudinal Aging Study Amsterdam
* Rotterdam Study
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518558
}}
{{medline-entry
|title=Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101309


==A Dynamic Anomaly Detection Approach Based on Permutation Entropy for Predicting Aging-Related Failures.==
|mesh-terms=* Aged, 80 and over
===Abstract===
* Aging
Software aging is a phenomenon referring to the performance degradation of a long-running software system. This phenomenon is an accumulative process during execution, which will gradually lead the system from a normal state to a failure-prone state. It is a crucial challenge for system reliability to predict the Aging-Related Failures (ARFs) accurately. In this paper, permutation entropy (PE) is modified to Multidimensional Multi-scale Permutation Entropy (MMPE) as a novel aging indicator to detect performance anomalies, since MMPE is sensitive to dynamic state changes. An experiment is set on the distributed database system Voldemort, and MMPE is calculated based on the collected performance metrics during execution. Finally, based on MMPE, a failure prediction model using the machine learning method to reveal the anomalies is presented, which can predict failures with high accuracy.
* Apolipoprotein E4
* Cognition
* Female
* Humans
* Longitudinal Studies
* Male
* Mental Status and Dementia Tests
* Prospective Studies


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137688
-
}}
{{medline-entry
|title=Interaction of [[APOE]], cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048144


===Keywords===
anomaly detection; failure prediction; machine learning; software aging


==Acoustic pre-stimulation modulates startle and postural reactions during sudden release of standing support surface in aging.==
|keywords=* APOE ε4
===Abstract===
* Aging
Falls contribute to injuries and reduced level of physical activity in older adults. During falls, the abrupt sensation of moving downward triggers a startle-like reaction that may interfere with protective response movements necessary to maintain balance. Startle reaction could be dampened by sensory pre-stimulation delivered immediately before a startling stimulus. This study investigated the neuromodulatory effects of pre-stimulation on postural/startle responses to drop perturbations of the standing support surface in relation to age. Ten younger and 10 older adults stood quietly on an elevated computer-controlled moveable platform. At an unpredictable time, participants were dropped vertically to elicit a startle-like response. Reactive drop perturbation trials without a pre-stimulus (control) were alternated with trials with acoustic pre-stimulus tone (PSI). A two-way mixed design analysis of variance comparing condition (control vs. PSI) X group (younger vs. older) was performed to analyze changes in muscle activation patterns, ground reaction force, and joint angular displacements. Compared to younger adults, older adults showed lower neck muscle electromyography amplitude reduction rate and incidence of response. Peak muscle activation in neck, upper arm, and hamstring muscles were reduced during PSI trials compared to control trials in both groups (p < 0.05). In addition, knee and hip joint flexion prior to ground contact was reduced in PSI trials compared to control (p < 0.05). During post-landing balance recovery, increased knee and hip flexion displacement and time to peak impact force were observed in PSI trials compared to control condition (p < 0.05). PSI reduced startle-induced muscle activation at proximal body segments and likely decreased joint flexion during abrupt downward vertical displacement perturbations of the body. Older adults retained the ability to modulate startle and postural responses but their neuromodulatory capacity was reduced compared with younger adults. Further research on the potential of applying PSI as a possible therapeutic tool to reduce the risk of fall-related injury is needed.
* Cerebral blood flow
* Cognitive decline
* Cortical thickness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165062
}}
{{medline-entry
|title=Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32057528


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Aging
* Alleles
* Amyloidogenic Proteins
* Apolipoprotein E4
* Cognitive Reserve
* Female
* Follow-Up Studies
* Genotype
* Humans
* Longitudinal Studies
* Male
* Neuropsychological Tests
* Organ Size
* Positron-Emission Tomography
* Sex Factors
* Temporal Lobe
|keywords=* APOE
* Amyloid load
* Cognitive changes
* Mesial temporal lobe
* Normal aging
* Structural MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.002
}}
{{medline-entry
|title=Long-term exposure to ambient air pollution, [[APOE]]-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31926436


===Keywords===
|mesh-terms=* Aged
Aging; Falls; Pre-stimulus inhibition; Startle
* Air Pollutants
* Air Pollution
* Apolipoprotein E4
* Apolipoproteins E
* Cognitive Dysfunction
* Female
* Genotype
* Humans
* Male
* Prospective Studies
* Washington
|keywords=* APOE-ε4 allele
* Aging
* Air pollution
* Cognitive decline
* Cognitive risk factors
* Epidemiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024003
}}
{{medline-entry
|title=Evidence in support of chromosomal sex influencing plasma based metabolome vs [[APOE]] genotype influencing brain metabolome profile in humanized [[APOE]] male and female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917799


==[Consensus and controversy on imaging of aging-related cerebral small vessel disease].==
|mesh-terms=* Age of Onset
===Abstract===
* Aging
---
* Alzheimer Disease
 
* Amyloid beta-Peptides
===MeSH Terms===
* Animals
Aging
* Apolipoprotein E4
* Apolipoproteins E
* Brain
* Brain
* Cerebral Small Vessel Diseases
* Disease Models, Animal
* Consensus
* Female
* Genotype
* Humans
* Humans
* Magnetic Resonance Imaging
* Magnetic Resonance Imaging
* Male
* Metabolome
* Mice
* Mice, Transgenic
* Sex Characteristics
* Sex Chromosomes


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952084
-
}}
{{medline-entry
|title=[[APOE]] region molecular signatures of Alzheimer's disease across races/ethnicities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31813627


==Human variation in response to food and nutrients.==
|mesh-terms=* Alleles
===Abstract===
* Alzheimer Disease
The application of science to human nutrition over the centuries has served societies well. One example is the identification of key nutrients to overcome nutritional deficiencies, which has enhanced life expectancy. Enhanced life expectancy, however, is associated with an increased prevalence of chronic disorders related to food and nutrition. Findings of studies indicating that individual responses to nutrients differ substantially between individuals make it necessary to re-examine the relationship between nutrition and human health. The emergence of new genomic-based technologies illustrates the complexity and scale of the interactions between nutrition and genetic factors. Epigenetic modifications resulting from interactions of the genetic profile, aging, and lifestyle can influence the time course of chronic disorders and contribute to human variability in response to nutritional interventions. Developing a better understanding of human variability as it applies to human nutrition will involve embracing the approaches and principles of complex science.
* Apolipoproteins E
* Continental Population Groups
* Haplotypes
* Heterozygote
* Homozygote
* Humans
* Linkage Disequilibrium
* Polymorphism, Single Nucleotide
* Risk Factors
|keywords=* APOE polymorphism
* Aging
* Alzheimer's disease
* Health span
* Life span
* Neurodegenerative disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064423
}}
{{medline-entry
|title=Varying Effects of [[APOE]] Alleles on Extreme Longevity in European Ethnicities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31724059


===MeSH Terms===
|mesh-terms=* Aged, 80 and over
-
* Alleles
* Apolipoproteins E
* Ethnic Groups
* Europe
* European Continental Ancestry Group
* Female
* Humans
* Longevity
* Male
|keywords=* APOE
* Bioinformatics
* Human genetics
* Longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330482
}}
{{medline-entry
|title=Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31686098


===Keywords===
|mesh-terms=* Aged
chronic diseases; complex science; epigenetics; genome; human variability; longevity; nutrition; personalized nutrition
* Aged, 80 and over
* Alzheimer Disease
* Anxiety
* Apolipoprotein E4
* Cognition
* Cognitive Dysfunction
* Cohort Studies
* Depression
* Efficiency
* Female
* Healthy Volunteers
* Humans
* Longitudinal Studies
* Male
* Mental Status and Dementia Tests
* Middle Aged
* Neuropsychological Tests
* Prospective Studies
* Risk Factors
* Sleep
* United Kingdom
* Work
|keywords=* Alzheimer Disease
* CHARIOT
* aging registry
* cognitive health
* pre-clinical
|full-text-url=https://sci-hub.do/10.14283/jpad.2019.31
}}
{{medline-entry
|title=Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658057


==Sustainability of residential environmental interventions and health outcomes in the elderly.==
|mesh-terms=* African Americans
===Abstract===
* Aged
Research has documented that housing conditions can negatively impact the health of residents. Asthma has many known indoor environmental triggers including dust, pests, smoke and mold, as evidenced by the 25 million people in the U.S. population who have asthma. The paper describes a follow-up study involving elder adults with asthma who participated in a multifaceted home educational and environmental intervention shown to produce significant health benefits. On average the time between the end of the prior intervention study and the follow-up was 2.3 years. The objective of this study was to evaluate whether improvements in environmental conditions and health outcomes resulting from the original Older Adult Study (OAS, multifaceted educational and environmental interventions) would be maintained or decline over time for these low income seniors with asthma. Health assessment included data on respiratory health outcomes included the Saint George's Respiratory Questionnaire (SGRQ) and Asthma Control Test from the original Older Adult Study (OAS) and this follow-up Older Adult Study (OAFS) along with health care utilization data. Environmental assessments included evaluation of asthma trigger activities (ATAs) and exposures before and after the original healthy homes intervention (questionnaire, home survey) and at this follow-up. Assessments were conducted in English, Khmer and Spanish. At assessment in the Older Adult Follow-up Study (OAFS), the older adults maintained some of the health improvements gained during the OAS when compared to the OAS pre-intervention baseline. However, health outcomes declined from the OAS final assessment to the OAFS (only the SGRQ Impact scores were significantly different). These findings suggest that further study with a larger population is needed to determine if the significant health outcome improvements from multifaceted home educational and environmental interventions (OAS) could be more strongly maintained by providing additional follow-up "booster" interventions to this older adult population with asthma.
* Alzheimer Disease
* Biomarkers
* Blood Flow Velocity
* Cardiovascular Diseases
* Cerebrovascular Circulation
* European Continental Ancestry Group
* Female
* Humans
* Male
* Middle Aged
* Risk Factors
|keywords=* African Americans
* Alzheimer’s disease
* Apolipoprotein E4
* aging
* cerebrovascular circulation
* glucose
* metabolic syndrome
* neuroimaging
* risk factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081660
}}
{{medline-entry
|title=Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31613323


===MeSH Terms===
-


===Keywords===
|keywords=* Alzheimers
Aging in place; Asthma; Environmental health; Healthy housing
* Cognitive aging
* Drug related
* Medication
|full-text-url=https://sci-hub.do/10.1093/gerona/glz244
}}
{{medline-entry
|title=Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630996


==Attendant's experience with the personalized citizen assistance for social participation (APIC).==
|mesh-terms=* Age Factors
===Abstract===
* Aged
To promote healthy aging, the social participation needs of older adults must be better met. Previous studies have shown the benefits of the Personalized citizen assistance for social participation (APIC), but few explored its influence on attendants. This study explored the assistance experience of attendants in providing the APIC to older adults with disabilities. A qualitative design inspired by a phenomenological approach was used with six female attendants who participated in individual interviews. The APIC attendants felt useful, developed meaningful relationships with their older adults, and improved their self-knowledge. Attendants had the opportunity to reflect on their lives and self-aging. They contributed to older adults' functional independence, motivation, and participation in social activities. Attendants encountered challenges related to withdrawn behavior in older adults, such as refusing to participate in activities. Considering the identified benefits of the APIC for attendants, further studies should explore personalized assistance to preserve older adults' health.
* Aged, 80 and over
* Alzheimer Disease
* Amyloid
* Biomarkers
* Cohort Studies
* Europe
* Female
* Humans
* Inflammation
* Male
* Middle Aged
* Parkinson Disease
* Sex Factors
* tau Proteins
|keywords=* Aging
* Alzheimer's disease
* Amyloid
* Biomarker
* Cerebrospinal fluid
* Inflammation
* Mild cognitive impairment
* Multicenter
* Parkinson's disease
* Tau
|full-text-url=https://sci-hub.do/10.1016/j.jalz.2019.07.018
}}
{{medline-entry
|title=Prospective Memory: Age related change is influenced by [[APOE]] genotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578124


===MeSH Terms===
-


===Keywords===
|keywords=*  APOE
Aging; Community integration; Community participation; Health promotion; Individualized assistance
* Alzheimer’s disease
* aging
* mid-adulthood
* prospective memory
|full-text-url=https://sci-hub.do/10.1080/13825585.2019.1671305
}}
{{medline-entry
|title=Education Moderates the Relation Between [[APOE]] ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594222


==Senescent cell accumulation mechanisms inferred from parabiosis.==
|mesh-terms=* Adult
===Abstract===
* African Americans
Senescent cells are growth-arrested cells that cause inflammation and play a causal role in aging. They accumulate with age, and preventing this accumulation delays age-related diseases. However, the mechanism for senescent cell accumulation is not fully understood. Accumulation can result from increasing production or decreasing removal of senescent cells with age, or both. To distinguish between these possibilities, we analyze data from parabiosis, the surgical conjoining of two mice so that they share circulation. Parabiosis between a young and old mouse, called heterochronic parabiosis, reduces senescent cell levels in the old mouse, while raising senescent cell levels in the young mouse. We show that parabiosis data can reject mechanisms for senescent cell accumulation in which only production rises with age or only removal decreases with age; both must vary with age. Since removal drops with age, senescent cell half-life rises with age. This matches a recent model for senescent cell accumulation developed from independent data on senescent cell dynamics, called the SR model, in which production rises linearly with age and senescent cells inhibit their own removal. The SR model further explains the timescales and mechanism of rejuvenation in parabiosis, based on transfer of spare removal capacity from the young mouse to the old. The present quantitative understanding can help design optimal treatments that remove senescent cells, by matching the time between treatments to the time it takes senescent cells to re-accumulate.
* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Apolipoprotein E4
* Cognitive Reserve
* Educational Status
* Executive Function
* Female
* Humans
* Male
* Memory
* Memory, Episodic
* Memory, Short-Term
* Middle Aged
* Neuropsychological Tests
* Sex Characteristics
|keywords=* APOE
* African American
* Alzheimer’s disease
* cognitive reserve
* educational attainment
* episodic memory
* genetic risk
* neuropsychological evaluation
|full-text-url=https://sci-hub.do/10.3233/JAD-190415
}}
{{medline-entry
|title=Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561966


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Aged
* Alleles
* Apolipoprotein E4
* Cognition Disorders
* European Continental Ancestry Group
* Executive Function
* Female
* Humans
* Longitudinal Studies
* Male
* Memory
* Neuropsychological Tests
* Sex Factors
|keywords=* Aging
* Alzheimer's disease
* Apolipoprotein E ε4
* Cognitive decline
* Sex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561018
}}
{{medline-entry
|title=Interactive effect of age and [[APOE]]-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520917


===Keywords===
|mesh-terms=* Age Factors
Aging; Mathematical modeling; Parabiosis; Senescent cells; Systems biology
* Aged
* Aging
* Apolipoprotein E4
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Myelin Sheath
* White Matter
|keywords=* Aging
* Alzheimer
* Apolipoprotein E
* Cognitively normal subjects
* Myelination
* T1w/T2w ratio
* White matter integrity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742967
}}
{{medline-entry
|title=[[APOE]] modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493534


==Epigenetic Clock Analysis in Children with Fetal Alcohol Spectrum Disorder.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
Fetal alcohol spectrum disorder (FASD) is characterized by severe clinical impairment, considerable social burden, and high mortality and morbidity, which are due to various malformations, sepsis, and cancer. As > 50% of deaths from FASD occur during the first year of life, we hypothesized that there is the acceleration of biological aging in FASD. Several recent studies have established genome-wide DNA methylation (DNAm) profiles as "epigenetic clocks" that can estimate biological aging, and FASD has been associated with differential DNAm patterns. Therefore, we tested this hypothesis using epigenetic clocks. We investigated five DNAm-based measures of epigenetic age (HorvathAge, HannumAge, SkinBloodAge, PhenoAge, and GrimAge) and telomere length (DNAmTL) using four independent publicly available DNAm datasets; two datasets were derived from buccal epithelium, and the other two datasets were derived from peripheral blood. Compared to controls, children with FASD exhibited an acceleration of GrimAge in one buccal and two blood datasets. No significant difference was found in other DNAm ages and DNAmTL. Meta-analyses showed a significant acceleration of GrimAge in the blood samples but not in the buccal samples. This study provides novel evidence regarding accelerated epigenetic aging in children with FASD.
* Apolipoproteins E
* Cerebral Cortex
* Cerebrovascular Circulation
* Entorhinal Cortex
* Female
* Genotype
* Humans
* Linear Models
* Male
* Memory
* Middle Aged
|keywords=* APOE ε4
* Aging
* Alzheimer’s disease
* Cerebral blood flow
* Cognitive decline
* Cortical thickness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819270
}}
{{medline-entry
|title=When time's arrow doesn't bend: [[APOE]]-ε4 influences episodic memory before old age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473197


===MeSH Terms===
|mesh-terms=* Adult
-
* Alleles
* Alzheimer Disease
* Apolipoprotein E4
* Cognition
* Cognitive Aging
* Female
* Genotype
* Humans
* Linear Models
* Male
* Memory
* Memory, Episodic
* Middle Aged
* Young Adult
|keywords=* Alzheimer's diseas
* Apolipoprotein E
* Cognition
* Episodic memory
* Semantic memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817416
}}
{{medline-entry
|title=Cognitive-Motor Integration Performance Is Affected by Sex, [[APOE]] Status, and Family History of Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424400


===Keywords===
|mesh-terms=* Aged
Biological Aging; DNA Methylation; Epigenetic Clock; Fetal Alcohol Spectrum Disorder; Prenatal Alcohol Use
* Apolipoproteins E
* Cognition
* Cognitive Dysfunction
* Cross-Sectional Studies
* Dementia
* Female
* Humans
* Male
* Medical History Taking
* Middle Aged
* Photic Stimulation
* Psychomotor Performance
* Sex Characteristics
* Surveys and Questionnaires
|keywords=* Aging
* alzheimer’s disease
* apolipoprotein E4
* dementia risk
* geriatric
assessment
* motor skills
* movement
* visuomotor integration
|full-text-url=https://sci-hub.do/10.3233/JAD-190403
}}
{{medline-entry
|title=Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31437719


==Microstructural differences in white matter tracts across middle to late adulthood: a diffusion MRI study on 7167 UK Biobank participants.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
White matter fiber tracts demonstrate heterogeneous vulnerabilities to aging effects. Here, we estimated age-related differences in tract properties using UK Biobank diffusion magnetic resonance imaging data of 7167 47- to 76-year-old neurologically healthy people (3368 men and 3799 women). Tract properties in terms of generalized fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity were sampled on 76 fiber tracts; for each tract, age-related differences were estimated by fitting these indices against age in a linear model. This cross-sectional study demonstrated 4 age-difference patterns. The dominant pattern was lower generalized fractional anisotropy and higher axial diffusivity, radial diffusivity, and mean diffusivity with age, constituting 45 of 76 tracts, mostly involving the association, projection, and commissure fibers connecting the prefrontal lobe. The other 3 patterns constituted only 14 tracts, with atypical age differences in diffusion indices, and mainly involved parietal, occipital, and temporal cortices. By analyzing the large volume of diffusion magnetic resonance imaging data available from the UK Biobank, the study has provided a detailed description of heterogeneous age-related differences in tract properties over the whole brain which generally supports the myelodegeneration hypothesis.
* Aging
* Amyloid beta-Peptides
* Atrophy
* Brain
* Cognition
* Cognitive Dysfunction
* Databases, Factual
* Female
* Humans
* Longitudinal Studies
* Male
* Middle Aged
|keywords=* Aging
* Alzheimer's disease
* Amyloid-β
* Brain atrophy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198229
}}
{{medline-entry
|title=Cognitive function and neuropathological outcomes: a forward-looking approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31435771


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Cognitive Dysfunction
* Female
* Humans
* Male
* Middle Aged
|keywords=* Alzheimer’s disease
* Cognition
* Multi-state model
* Neuropathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851487
}}
{{medline-entry
|title=[[APOE]] gene-dependent BOLD responses to a breath-hold across the adult lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408838


===Keywords===
|mesh-terms=* Adult
Brain aging; Diffusion MRI; Fiber degeneration; Magnetic resonance imaging; UK Biobank; White matter
* Aged
* Aging
* Apolipoprotein E3
* Apolipoprotein E4
* Apolipoproteins E
* Breath Holding
* Cerebrovascular Circulation
* Cross-Over Studies
* Double-Blind Method
* Female
* Genotype
* Hemodynamics
* Humans
* Longevity
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Nitrates
|keywords=* Ageing
* Alzheimer's disease
* Apolipoprotein E
* BOLD fMRI
* Breath-hold
* Cerebrovascular reactivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699560
}}
==APP==


==Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities.==
{{medline-entry
===Abstract===
|title=Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age-related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age-related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age-related disorders in the current era of precision medicine.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917871


===MeSH Terms===
|mesh-terms=* Aging
-
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Behavior, Animal
* Cognitive Dysfunction
* Cytokines
* Dipeptides
* Disease Models, Animal
* Encephalitis
* Female
* Humans
* Inflammation
* Male
* Memory Disorders
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Serpins
* Spatial Memory
* Viral Proteins
* para-Aminobenzoates


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486940
aging; clinical trials; healthspan; senescent cells; senolytics; senotherapy
}}
{{medline-entry
|title=Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660121


==HCAR Is a Limitation Factor for Chlorophyll Cycle and Chlorophyll [i]b[/i] Degradation in Chlorophyll-[i]b[/i]-Overproducing Plants.==
===Abstract===
The chlorophyll (Chl) cycle is the metabolic pathway for Chl [i]a[/i] and Chl [i]b[/i] inter-conversion. In this pathway, Chl [i]b[/i] is synthesized from Chl [i]a[/i] by the catalyzing action of chlorophyllide [i]a[/i] oxygenase (CAO). In contrast, Chl [i]b[/i] is firstly reduced to produce 7-hydroxymethyl Chl (HMChl) [i]a[/i], which is catalyzed by two isozymes of Chl [i]b[/i] reductase (CBR), non-yellow coloring 1 (NYC1) and NYC1-like (NOL). Subsequently, HMChl [i]a[/i] is reduced to Chl [i]a[/i] by HMChl [i]a[/i] reductase (HCAR). CAO plays a pivotal role in Chl [i]a[/i]/[i]b[/i] ratio regulation and plants over-accumulate Chl [i]b[/i] in CAO-overexpressing plants. NYC1 is more accumulated in Chl-[i]b[/i]-overproducing plants, while HCAR is not changed. To investigate the role of HCAR in Chl cycle regulation, the Chl metabolites of Chl-[i]b[/i]-overproducing plants were analyzed. The results showed that HMChl [i]a[/i] accumulated in these plants, and it decreased and the Chl [i]a[/i]/[i]b[/i] ratio increased by overexpressing HCAR, implying HCAR is insufficient for Chl cycle in Chl-[i]b[/i]-overproducing plants. Furthermore, during dark-induced senescence, the non-programmed cell death symptoms (leaves dehydrated with green color retained) of Chl-[i]b[/i]-overproducing plants were obviously alleviated, and the content of HM pheophorbide (HMPheide) [i]a[/i] and Pheide [i]b[/i] were sharply decreased by overexpressing HCAR. These results imply that HCAR is also insufficient for Chl degradation in Chl-[i]b[/i]-overproducing plants during senescence, thus causing the accumulation of Chl metabolites and non-programmed cell death of leaves. With these results taken together, we conclude that HCAR is not well regulated and it is a limiting factor for Chl cycle and Chl [i]b[/i] degradation in Chl-[i]b[/i]-overproducing plants.


===MeSH Terms===
|keywords=* aging
-
* amyloid beta
* dendritic spine
* neuroinflammation
* regorafenib
* tau
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408082
}}
{{medline-entry
|title=An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of [[APP]] homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32588983


===Keywords===
HCAR; cell death; chlorophyll cycle; chlorophyll degradation; leaf senescence


==Disease- and Treatment-related Complications in Older Patients With Inflammatory Bowel Diseases: Comparison of Adult-onset vs Elderly-onset Disease.==
|keywords=* aging
===Abstract===
* amyloid hypothesis
The incidence and prevalence of inflammatory bowel diseases (IBD) in older adults are rising. There is a limited comparative assessment of risk of disease- and treatment-related complications in older patients (older than 60 years) with adult-onset (age at disease onset, 18-59 years; AO-IBD) vs elderly-onset IBD (age at disease onset, older than 60 years; EO-IBD). We compared clinical outcomes in older patients with IBD with AO-IBD vs EO-IBD. We conducted a retrospective cohort study comparing risk of disease-related complications (IBD-related surgery, hospitalization, treatment escalation, clinical flare, or disease complication) and treatment-related complications (serious infection, malignancy, or death) in older patients with AO-IBD vs EO-IBD through Cox proportional hazard analysis, adjusting for age at cohort entry, disease phenotype, disease duration, prior surgery and/or hospitalization, medication use, disease activity at cohort entry, and comorbidities. We included 356 older patients with IBD (AO-IBD, 191 patients, 67 ± 5 y at cohort entry; EO-IBD, 165 patients, 72 ± 8 y at cohort entry). No significant differences were observed in the risk of disease-related complications in older patients with prevalent vs incident IBD (adjusted hazard ratio [aHR], 0.85; 95% CI, 0.58-1.25), although risk of IBD-related surgery was lower in older patients with prevalent IBD (aHR, 0.47; 95% CI, 0.25-0.89). Older patients with prevalent IBD were significantly less likely to experience treatment-related complications (aHR, 0.58; 95% CI, 0.39-0.87). Patients with AO-IBD have lower risk of treatment-related complications as they age compared with patients with EO-IBD, without a significant difference in risk of disease-related complications.
* amyloid precursor protein homeostasis
* late onset Alzheimer's disease
* young onset Alzheimer's disease
|full-text-url=https://sci-hub.do/10.1002/alz.12124
}}
{{medline-entry
|title=Transcriptomic profiling of microglia and astrocytes throughout aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238175


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Crohn’s disease; aging; biologics; colitis; infections
* Alzheimer’s disease (AD)
* Astrocyte
* Microglia
* RNA-seq
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115095
}}
{{medline-entry
|title=Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194368


==Alleviation of tributyltin-induced toxicity by diet and microplastics in the marine rotifer Brachionus koreanus.==
===Abstract===
To determine the effects of tributyltin (TBT) upon multiple exposures of diet and microplastic in rotifer, in vivo life parameters were measured. In 10 μg/L TBT-exposed rotifer, the 1 and 0.5 x diet groups resulted in reproduction reduction. However, 10 x diet treatment showed no significant changes in the total fecundity, despite a decrease in daily reproduction. Besides, differences in the lifespan were observed in response to different diet regimens. TBT and/or MP-exposed parental rotifer (F0) showed a significant delay in the pre-reproductive day under 0.5 x diet regimen. In all dietary regimens, exposure to TBT and MP induced an increase in reactive oxygen species, but antioxidant activities were perturbed. To further verify the carryover effect of TBT toxicity, progeny rotifer (F1) obtained from 24 h TBT and/or MP-exposed F0 was used. Interestingly, the faster hatching rate was observed only in F1 obtained from 1 x diet regimen-exposed F0. However, in the 0.5 x diet, the total fecundity was reduced and the pattern of the daily reproduction was collapsed. Thus, the toxicity of TBT can be alleviated by MP and nutrition status, but TBT-induced toxicity and its carryover effect are inevitable.


===MeSH Terms===
|keywords=* Alzheimer’s disease
-
* aging
* astrocytes
* platelets
* vascular pathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063083
}}
{{medline-entry
|title=CHIP modulates [[APP]]-induced autophagy-dependent pathological symptoms in Drosophila.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31777182


===Keywords===
|mesh-terms=* Alzheimer Disease
Acute toxicity; Chronic toxicity; Lifespan; Maternal effect; Reproduction
* Amyloid beta-Protein Precursor
* Animals
* Aspartic Acid Endopeptidases
* Autophagy
* Brain
* Cognitive Dysfunction
* Disease Models, Animal
* Dopaminergic Neurons
* Down-Regulation
* Drosophila
* Drosophila Proteins
* Eye
* Learning Disabilities
* Locomotion
* Longevity
* Nuclear Proteins
* Presenilins
* RNA Interference
* Wings, Animal
|keywords=*
CHIP


==On nitrogen fixation and "residual nitrogen content" in cellulosic pulps.==
* APP
===Abstract===
* Alzheimer’s disease
Cellulosic material is capable of permanently retaining nitrogen compounds (mostly having amino functions), which is reflected in a residual nitrogen content (in the low per mille range to the low percent range) of some pulps and certain lab samples. Merely adsorptively bound compounds can be removed by mild acidic washing, but part of the nitrogen seems to be resistant and very tightly bound, and thus not accessible for removal by washing. Tertiary and aromatic amines are not retained in this way, but only primary and secondary amines. There is only a weak correlation between the "firmly bound nitrogen" and the carbonyl content in cellulosics (because of oxidative damage), so that possible aminal, Schiff base and enamine structures can hardly be relevant as major nitrogen sources. However, there is a very good linear correlation between the ISO brightness (chromophore content) in aged pulps and the residual nitrogen content. In particular the concentration of the cellulosic key chromophore 2,5-dihydroxy-[1,4]-benzoquinone (DHBQ) determines the permanent N-binding capacity of the pulp. DHBQ reacts very readily with primary and secondary amines under ambient conditions to 2,5-diamino-substituted [1,4]-benzoquinones, which have very low solubility (because of zwitterionic resonance contributions) and thus remain on/in the pulp. Examples of nitrogen fixation in pulps are the binding of piperidine (a common amine catalyst in derivatization reactions), amine degradation products of the cellulose solvent NMMO, dimethylamine in materials processed from the cellulose solvent DMAc/LiCl, imidazole (a degradation product of 1-alkyl-3-methylimidazolium ionic liquids), and of amino groups in proteins after enzymatic treatment. The nature of the respective DHBQ-amine addition compound has been verified by complete structure determination.
* Aβ
* autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996943
}}
{{medline-entry
|title=Studies on [[APP]] metabolism related to age-associated mitochondrial dysfunction in [[APP]]/PS1 transgenic mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744937


===MeSH Terms===
|mesh-terms=* Adenosine Triphosphate
-
* Aging
* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Blood Platelets
* Disease Models, Animal
* Hippocampus
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Mitochondria
* Presenilin-1
|keywords=* APP/PS1 mice
* Amyloid-beta
* adenosine 5’-triphosphate
* mitochondria dysfunction
* platelets
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914425
}}
{{medline-entry
|title=Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31671598


===Keywords===
|mesh-terms=* Aged
Aging; Cellulose; Chromophores; Nitrogen fixation; Pulp; Residual nitrogen; Yellowing
* Alzheimer Disease
* Biomarkers
* Case-Control Studies
* Cognition
* Cognitive Dysfunction
* Female
* Humans
* Hyperoxia
* Hypoxia
* Male
* Middle Aged
* Pilot Projects
* Respiratory Therapy
* Treatment Outcome
|keywords=* Alzheimer’s disease
* adaptation
* aging
* amyloid beta
* biomarker
* cognitive function
* hyperoxia
* intermittent hypoxia
* platelets
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862463
}}
{{medline-entry
|title=The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677609


==Corrigendum: The Aging Slopes of Brain Structures Vary by Ethnicity and Sex: Evidence From a Large Magnetic Resonance Imaging Dataset From a Single Scanner of Cognitively Healthy Elderly People in Korea.==
|mesh-terms=* Adult
===Abstract===
* Aged
[This corrects the article DOI: 10.3389/fnagi.2020.00233.].
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid Precursor Protein Secretases
* Amyloid beta-Peptides
* Androgens
* Aspartic Acid Endopeptidases
* Cognition
* Cognitive Dysfunction
* Cyclic AMP Response Element-Binding Protein
* Female
* Hippocampus
* Humans
* Learning
* MAP Kinase Signaling System
* Male
* Middle Aged
* Neoplasm Proteins
* Phosphorylation
* Protein Kinase C
* Receptors for Activated C Kinase
* tau Proteins
|keywords=* Androgens
* Cognition
* Hippocampus
* Protein kinase C
* Spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984714
}}
{{medline-entry
|title=Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31596471


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
aging slope; ethnic difference; norm; normal aging; sex difference
* Alaska pollack protein
* Motor unit identification
* Multichannel surface electromyography
* Nutritional supplementation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164534
}}
{{medline-entry
|title=Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480982


==Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of type II fibers and infiltration by inflammatory cells. Muscle strength decreased in parallel. Pharmacological TNFα blockade by weekly subcutaneous injection of Etanercept from 16 to 28 months of age prevented atrophy and loss of type II fibers, with significant improvements in muscle function and mice lifespan. The effects on leukocyte recruitment were limited. These results provide a proof of principle that endogenous TNFα is sufficient to cause sarcopenia and to reduce animal survival, and open a novel perspective on novel potential pharmacological treatment strategies based on TNFα blockade to prevent the noxious events associated with aging.
* Aging
* Antipsychotic Agents
* Asian Continental Ancestry Group
* Female
* Humans
* Male
* Middle Aged
* Polypharmacy
* Schizophrenia
|keywords=* Asian
* antipsychotic polypharmacy
* older adult patients
* schizophrenia
|full-text-url=https://sci-hub.do/10.1177/0891988719862636
}}
{{medline-entry
|title=A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31479861


===MeSH Terms===
|mesh-terms=* Amyloid beta-Protein Precursor
-
* Brain
* Down Syndrome
* Exosomes
* Humans
|keywords=* APP
* APP-CTFs
* Aging
* Brain
* Down syndrome
* Exosomes
* Extracellular vesicles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960325
}}
==APPL1==


===Keywords===
{{medline-entry
TNF alpha; aging; inflammation; pharmacological intervention; sarcopenia
|title=Insulin and adipokine signaling and their cross-regulation in postmortem human brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31539648


==Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.==
|mesh-terms=* Adipokines
===Abstract===
* Aging
Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from young and older adults. The expression of key proteins of mitochondrial quality control (MQC) and the abundance of the mitochondrial DNA common deletion (mtDNA ) were also assessed. An inverse association was found between total Fe and the heavier Fe isotope ( Fe), indicating an increase in labile Fe abundance in cells with greater Fe content. The highest levels of labile Fe were detected in old participants with a Short Physical Performance Battery (SPPB) score ≤ 7 (low-functioning, LF). Protein levels of mitoferrin and frataxin were, respectively, higher and lower in the LF group relative to young participants and older adults with SPPB scores ≥ 11 (high-functioning, HF). The mtDNA  relative abundance was greater in old than in young participants, regardless of SPPB category. Higher protein levels of Pink1 were detected in LF participants compared with young and HF groups. Finally, the ratio between lipidated and non-lipidated microtubule-associated protein 1A/1B-light chain 3 (i.e., LC3B II/I), as well as p62 protein expression was lower in old participants regardless of SPPB scores. Our findings indicate that cellular and mitochondrial Fe homeostasis is perturbed in the aged muscle (especially in LF older adults), as reflected by altered levels of mitoferrin and frataxin, which, together with MQC derangements, might contribute to loss of mtDNA stability.
* Brain
* Humans
* Insulin
* Leptin
* Postmortem Changes
* Signal Transduction
|keywords=* Adipokine
* Adiponectin receptors
* Alzheimer's disease–related dementias
* Leptin receptors
* Postmortem brain
* Type 2 diabetes
* insulin signaling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960343
}}
==AQP3==


===MeSH Terms===
{{medline-entry
-
|title=Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592290


===Keywords===
autophagy; iron dyshomeostasis; iron isotopes; iron metabolism; mitochondria; mitochondrial quality control; mitophagy; muscle aging; oxidative stress; physical performance


==City government's adoption of housing adaptation policy innovation for older adults: Evidence from China.==
|keywords=* adipocytes
===Abstract===
* aging
Utilizing policy innovation and diffusion theory, this study aims to explain why city governments adopt housing adaptation policies that primarily benefit older people based on the case of China. The data are drawn from an event history dataset of a housing adaptation policy for older people collected from 283 Chinese cities from 2010 to 2018. Piecewise constant exponential models are utilized. The results indicate that cities facing greater internal pressure and a higher political status are more likely to adopt a housing adaptation policy for older people. Policy adoption by neighboring cities could further facilitate this process. Policy innovation and diffusion theory provides a useful framework for this study. That is, the Chinese city government's adoption of housing adaptation policy for older adults is initially driven by local needs and then accelerated by interactions among neighboring governments.
* cosmetics
* face
* fat pads
* integument
* subcutis
* wrinkles
|full-text-url=https://sci-hub.do/10.1002/term.3087
}}
==AR==


===MeSH Terms===
{{medline-entry
-
|title=Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32650419


===Keywords===
Aging in place; Housing accessibility; Piecewise constant exponential model; Policy innovation


==Higher Impact Physical Activity is Associated with Maintenance of Bone Mineral Density but Not Reduced Incident Falls or Fractures in Older Men: The Concord Health and Ageing in Men Project.==
|keywords=* PKB/Akt
===Abstract===
* Src
High-impact physical activities with bone strains of high magnitude and frequency may benefit bone health. This study aimed to investigate the longitudinal associations between changes in loading intensities and application rates, estimated from self-reported physical activity, with bone mineral density (BMD) changes over five years, and also with incident falls over two years and long-term incident fractures, in community-dwelling older men. 1,599 men (mean age 76.8±5.4 years) from the Concord Health and Ageing in Men Project (CHAMP) were assessed at baseline (2005-2007), 2-year and 5-year follow-up. At each time point, hip and lumbar spine BMD were measured by dual-energy x-ray absorptiometry, and physical activity energy expenditure over the past week was self-reported via the Physical Activity Scale for the Elderly (PASE) questionnaire. Sum effective load ratings (ELRs) and peak force were estimated from the PASE questionnaire, reflecting the total and highest loading intensity and application rate of physical activities, respectively. Participants were contacted every 4 months over two years to self-report falls, and over 6.0±2.2 years for fractures. Hip fractures were ascertained by data-linkage for 8.9±3.6 years. Compared to sum ELR and PASE scores, peak force demonstrated the greatest standardised effect size for BMD maintenance at the spine (β=9.77mg/cm  ), total hip (β=14.14mg/cm  ) and femoral neck (β=13.72mg/cm  ) after adjustment for covariates, including PASE components (all p<0.01). Only PASE scores were significantly associated with reduced falls risk (standardised incident rate ratio=0.90, 95% confidence interval=0.81-1.00, p=0.04). All physical activity measures were significantly associated with reduced incident fractures in univariate analyses but none remained significant after multivariable adjustments. Older men who engaged in physical activity of high and rapid impact maintained higher BMD, while higher energy expenditure was associated with reduced falls risk. Coupling traditional physical activity data with bone loading estimates may improve understanding of the relationships between physical activity and bone health. This article is protected by copyright. All rights reserved.
* androgen receptor antagonist
* antiandrogen
* bipolar androgen therapy
* cellular senescence
* prostate cancer
* supraphysiological androgen levels
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408918
}}
{{medline-entry
|title=Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32562083


===MeSH Terms===
-


===Keywords===
|keywords=* Androgen receptor antagonists
Exercise; aging; fracture prevention; general population studies; osteoporosis
* Cellular senescence
* Interleukin-23
* Prostate cancer spheroids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335377
}}
{{medline-entry
|title=A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460027


==Is impaired dopaminergic function associated with mobility capacity in older adults?==
===Abstract===
The capacity to move is essential for independence and declines with age. Slow movement speed, in particular, is strongly associated with negative health outcomes. Prior research on mobility (herein defined as movement slowness) and aging has largely focused on musculoskeletal mechanisms and processes. More recent work has provided growing evidence for a significant role of the nervous system in contributing to reduced mobility in older adults. In this article, we report four pieces of complementary evidence from behavioral, genetic, and neuroimaging experiments that, we believe, provide theoretical support for the assertion that the basal ganglia and its dopaminergic function are responsible, in part, for age-related reductions in mobility. We report four a posteriori findings from an existing dataset: (1) slower central activation of ballistic force development is associated with worse mobility among older adults; (2) older adults with the Val/Met intermediate catecholamine-O-methyl-transferase (COMT) genotype involved in dopamine degradation exhibit greater mobility than their homozygous counterparts; (3) there are moderate relationships between performance times from a series of lower and upper extremity tasks supporting the notion that movement speed in older adults is a trait-like attribute; and (4) there is a relationship of functional connectivity within the medial orbofrontal (mOFC) cortico-striatal network and measures of mobility, suggesting that a potential neural mechanism for impaired mobility with aging is the deterioration of the integrity of key regions within the mOFC cortico-striatal network. These findings align with recent basic and clinical science work suggesting that the basal ganglia and its dopaminergic function are mechanistically linked to age-related reductions in mobility capacity.


===MeSH Terms===
|keywords=* adipocyte
-
* adipose tissue
* aging
* lncRNA
* long non-coding RNA
* non-coding RNA
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603645
}}
{{medline-entry
|title=Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32351687


===Keywords===
Aging; Basal ganglia; Dopamine; Mobility; Neural control; Sarcopenia


==The Resistance of [i]Drosophila melanogaster[/i] to Oxidative, Genotoxic, Proteotoxic, Osmotic Stress, Infection, and Starvation Depends on Age According to the Stress Factor.==
|keywords=* Akt inhibitor
===Abstract===
* Antiandrogen
We studied how aging affects the ability of [i]Drosophila melanogaster[/i] to tolerate various types of stress factors. Data were obtained on the resistance of [i]D. melanogaster[/i] to oxidative and genotoxic (separately paraquat, Fe , Cu , and Zn  ions), proteotoxic (hyperthermia, Cd  ions), and osmotic (NaCl) stresses, starvation, and infection with the pathological [i]Beauveria bassiana[/i] fungus at different ages. In all cases, we observed a strong negative correlation between age and stress tolerance. The largest change in the age-dependent decline in survival occurred under oxidative and osmotic stress. In most experiments, we observed that young [i]Drosophila[/i] females have higher stress resistance than males. We checked whether it is possible to accurately assess the biological age of [i]D. melanogaster[/i] based on an assessment of stress tolerance. We have proposed a new approach for assessing a biological age of [i]D. melanogaster[/i] using a two-parameter survival curve model. For the model, we used an algorithm that evaluated the quality of age prediction for different age and gender groups. The best predictions were obtained for females who were exposed to CdCl  and ZnCl  with an average error of 0.32 days and 0.36 days, respectively. For males, the best results were observed for paraquat and NaCl with an average error of 0.61 and 0.68 days, respectively. The average accuracy for all stresses in our model was 1.73 days.
* Bcl-2 family inhibitor
* Bipolar androgen therapy
* Cellular senescence
* HSP90 inhibitor
* Prostate cancer
* Senolytic compounds
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183592
}}
{{medline-entry
|title=Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32017595


===MeSH Terms===
|mesh-terms=* Adipocytes
-
* Adipose Tissue
* Animals
* Anti-Bacterial Agents
* Diet
* Diet, High-Fat
* Feces
* Female
* Gastrointestinal Microbiome
* Lipid Metabolism
* Longevity
* Male
* Metabolic Diseases
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Obesity
* Receptors, Androgen
* Sex Characteristics
|keywords=* androgen-insensitive syndrome
* longevity
* metabolic syndrome
* testosterone
* type 2 diabetes
|full-text-url=https://sci-hub.do/10.1152/ajpendo.00461.2019
}}
{{medline-entry
|title=A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32003372


===Keywords===
|mesh-terms=* Aging
Drosophila melanogaster; aging; biomarkers of aging; modeling; stress resistance
* Animals
* Cell Proliferation
* Diet, High-Fat
* Male
* Mice
* Myrtaceae
* Plant Extracts
* Prostate


==Interaction Information Along Lifespan of the Resting Brain Dynamics Reveals a Major Redundant Role of the Default Mode Network.==
|full-text-url=https://sci-hub.do/10.1039/c9fo02621e
===Abstract===
}}
Interaction Information (II) generalizes the univariate Shannon entropy to triplets of variables, allowing the detection of redundant (R) or synergetic (S) interactions in dynamical networks. Here, we calculated II from functional magnetic resonance imaging data and asked whether R or S vary across brain regions and along lifespan. Preserved along lifespan, we found high overlapping between the pattern of high R and the default mode network, whereas high values of S were overlapping with different cognitive domains, such as spatial and temporal memory, emotion processing and motor skills. Moreover, we have found a robust balance between R and S among different age intervals, indicating informational compensatory mechanisms in brain networks.
{{medline-entry
|title=Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31546163


===MeSH Terms===
|mesh-terms=* Adolescent
-
* Adult
* Aged
* Aged, 80 and over
* Aging
* Child
* Child, Preschool
* Cohort Studies
* CpG Islands
* DNA Methylation
* Forensic Genetics
* Genetic Markers
* Humans
* Infant
* Infant, Newborn
* Linear Models
* Middle Aged
* Oligonucleotide Array Sequence Analysis
* Young Adult
|keywords=* Age
* CpG sites
* DNA methylation
* Forensic age estimation
* Forensic epigenetics
* Illumina MethylationEPIC
|full-text-url=https://sci-hub.do/10.1016/j.forsciint.2019.109944
}}
==ARC==


===Keywords===
{{medline-entry
default mode network; interaction information; lifespan; redundancy; resting state; synergy
|title=The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877255


==Development of normative data for the Five Point Test using the cognitive reliability and time to failure rate theory.==
|mesh-terms=* Aged
===Abstract===
* Aging
In this study, several theoretically based curve fitting nonlinear models for analyzing the Five Point Test (FPT), a nonverbal fluency test, were examined. One thousand two hundred and one participants from the general population of Germany and the USA completed the FPT. The test scores were analyzed using three process indexes; the number of unique designs, strategy, and repetitions. Participants were stratified by age and level of education, and the resulting data were examined using best-fit nonlinear distribution equations. The study shows that the Weibull Growth three-factor curve fitting model provides equivalent fit as four-factor quadratic or linear curve fitting models for estimates continue normative data the Reliability and Time to Failure Theory of Cognitive Functions. Namely, that neurocognitive abilities remain stable during young adulthood and after reaching a threshold, starts to linearly or exponentially decline. The study also shows that education differentially impacts the asymptote, threshold, and decline rate of the FPT indexes confirming the importance of isolating specific cognitive domains within neuropsychological tests as these indexes might be related to the activation of particular cell assemblies, which in turn are differentially impacted by aging.
* Alleles
* Cataract
* Female
* Gene Expression Regulation
* Genetic Association Studies
* Genetic Predisposition to Disease
* Genotype
* Haplotypes
* Humans
* Hydroxymethylglutaryl CoA Reductases
* Intramolecular Transferases
* Lens, Crystalline
* Male
* Middle Aged
* Polymorphism, Single Nucleotide
|keywords=* ARC
* HMGCR
* LSS
* SNPs
* lanosterol
|full-text-url=https://sci-hub.do/10.1089/dna.2020.5872
}}
{{medline-entry
|title=Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554955


===MeSH Terms===
-


===Keywords===
|keywords=* Müllerian inhibiting substance
Aging; nonverbal fluency; reliability theory
* female reproductive senescence
* gonadotropin-releasing hormone neuron
* preoptic area
* ruminant
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468072
}}
{{medline-entry
|title=Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746523


==Can Melatonin Be a Potential "Silver Bullet" in Treating COVID-19 Patients?==
|mesh-terms=* Animals
===Abstract===
* Cataract
The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential "silver bullet" in the COVID 19 pandemic.
* Dose-Response Relationship, Drug
* Male
* Naphthalenes
* Rats
* Rats, Sprague-Dawley
* Resveratrol
|keywords=* age-related cataracts
* aging
* oxidative stress
* resveratrol
|full-text-url=https://sci-hub.do/10.1002/jbt.22420
}}
==AREG==


===MeSH Terms===
{{medline-entry
-
|title=Targeting amphiregulin ([[AREG]]) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493351


===Keywords===
|mesh-terms=* Amphiregulin
COVID-19 pandemic; aging; anti-SARS-CoV-2 vaccination; chronotherapy; cognitive impairment; cytoprotection; diabetes; inflammation; melatonin; metabolic syndrome; neurodegeneration; oxidative stress; renin–angiotensin system
* Animals
* Antineoplastic Agents
* B7-H1 Antigen
* Cells, Cultured
* Cellular Senescence
* Drug Resistance, Neoplasm
* Humans
* Mice
* Mice, Inbred NOD
* Mice, SCID
* Stromal Cells
* Tumor Microenvironment
|keywords=* aging
* amphiregulin
* cancer resistance
* clinical biomarker
* combinational treatment
* programmed cell death 1 ligand
* senescence-associated secretory phenotype
* stroma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826133
}}
==ARNT==


==Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization.==
{{medline-entry
===Abstract===
|title=Loss of [[ARNT]] in skeletal muscle limits muscle regeneration in aging.
To evaluate whether the telomere length of white blood cells (WBC) and cumulus cells (CC) in an infertile population is associated with ovarian and embryonic performance. Prospective cohort study. Academic-affiliated private practice. A total of 175 infertile women undergoing in vitro fertilization (IVF) at a single center between July 2017 and December 2018. On the day of oocyte retrieval, genomic DNA was isolated from WBC and CC samples. Telomere length assessment was performed for both tissue types using quantitative real-time polymerase chain reaction. Telomere lengths were normalized using an AluYa5 sequence as an endogenous control, and linear regressions were applied. This study assessed the relationship between relative telomere length of WBC and CC samples and measures of ovarian and embryonic performance. Specifically, patient age, antimüllerian hormone (AMH) level, peak estradiol (E ) level, number of oocytes retrieved, number of mature (MII) oocytes retrieved, blastulation rate, and aneuploidy rate were assessed. There was a statistically significant relationship between WBC relative telomere length and patient age as well as rates of embryonic aneuploidy, with shorter WBC relative telomere length associated with increasing patient age (P<.01) and higher rates of aneuploidy (P=.01). No statistically significant relationships were observed between WBC relative telomere length and the other outcome measures. No significant associations were noted between CC relative telomere length and any outcomes assessed in this study. The relationship between WBC relative telomere length and aneuploidy warrants further investigation, particularly because significant overlap exists between increasing maternal age and rates of embryonic aneuploidy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33064329


===MeSH Terms===
-


===Keywords===
|keywords=* aging
Cumulus cells; female infertility; ovarian biology; reproductive aging; telomere length
* hypoxia signaling
* muscle regeneration
|full-text-url=https://sci-hub.do/10.1096/fj.202000761RR
}}
{{medline-entry
|title=[Arylhydrocarbon receptor nuclear translocator ([[ARNT]]) in human skin during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32593246


==Therapy-induced polyploidization and senescence: Coincidence or interconnection?==
|mesh-terms=* Adolescent
===Abstract===
* Adult
Polyploid somatic cells have 'programmed' roles in normal development and stress responses. Transient polyploidy states have been observed in several tumor types at early stages of tumorigenesis. They can give rise to the aneuploidy state which is a common feature of human cancer cells. Similarly, to cancer development, cancer treatment can lead to transient polyploidy. Polyploid giant cells (PGCCs) in cancer are often associated with poor prognosis and disease relapse. Cancer cell senescence- a proliferation arrest accompanied by a set of characteristic markers- induced by therapy is also associated with transient polyploidy formation and cancer relapse. The question is whether therapy-induced senescence (TIS) and therapy induced polyploidy (TIP) are mechanistically or coincidentally connected. This problem needs to be solved rather urgently, because TIS appears to be more common phenomena than originally believed. Another arising question concerns reversibility of cancer cell senescence as a consequence of atypical divisions of polyploid cells. In our review we will try to answer this fundamental question by referring to published literature and to our own studies.
* Aged
* Aged, 80 and over
* Aging
* Aryl Hydrocarbon Receptor Nuclear Translocator
* Child
* Child, Preschool
* Dermis
* Fetus
* Fibroblasts
* Humans
* Infant
* Infant, Newborn
* Skin
* Skin Aging
* Young Adult
|keywords=* ARNT
* PCNA
* aging
* fibroblasts
* skin


===MeSH Terms===
}}
-
{{medline-entry
|title=The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041778


===Keywords===
Amitotic divisions; PGCCs; Senescence escape; Therapy-induced senescence


==Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence.==
|keywords=* E3 ubiquitin ligase
===Abstract===
* STIP1 homology and U-box-containing protein 1 (STUB1)
Cancer treatment has been associated with accelerated aging that can lead to early-onset health complications typically experienced by older populations. In particular, cancer survivors have an increased risk of developing premature cardiovascular complications. In the last two decades, cellular senescence has been proposed as an important mechanism of premature cardiovascular diseases. Cancer treatments, specifically anthracyclines and radiation, have been shown to induce senescence in different types of cardiovascular cells. Additionally, clinical studies identified increased systemic markers of senescence in cancer survivors. Preclinical research has demonstrated the potential of several approaches to mitigate cancer therapy-induced senescence. However, strategies to prevent and/or treat therapy-induced cardiovascular senescence have not yet been translated to the clinic. In this review, we will discuss how therapy-induced senescence can contribute to cardiovascular complications. Thereafter, we will summarize the current in vitro, in vivo, and clinical evidence regarding cancer therapy-induced cardiovascular senescence. Then, we will discuss interventional strategies that have the potential to protect against therapy-induced cardiovascular senescence. To conclude, we will highlight challenges and future research directions to mitigate therapy-induced cardiovascular senescence in cancer survivors.
* brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3)
* cell cycle regulation
* circadian clock
* hydrogen peroxide
* proteasome
* protein degradation
* senescence
* ubiquitylation (ubiquitination)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135990
}}
==ASB7==


===MeSH Terms===
{{medline-entry
-
|title=[[ASB7]] Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251222


===Keywords===
Senescence; cancer therapy; cardio-oncology; cardiotoxicity; cardiovascular diseases; doxorubicin; radiation


=="Building the Threads of Connection that We Already Have": The Nature of Connections via Technology for Older People.==
|keywords=* ASBs
===Abstract===
* maternal aging
: The social connectedness of older people is of increasing concern. Technology has been suggested for enhancing social inclusion. This study aimed to explore the nature and quality of connections via technology.  : Qualitative exploration of experiences, stories, and needs was undertaken through semi-structured interviews with older (7) and middle-aged (3) adults with rich experience of connections via technology in Australia and England. Core aspects of connections through technology were constructed through interpretive description analysis. : Four key aspects were: 1. [i]The caliber of connections[/i]: descriptions of a range of subjective quality of connections and characteristics of good connections; 2. Experiences of poor connection ([i]mis- and dis-connection[/i]) including descriptions of experiences creating isolation; 3. [i]Reasons to connect[/i] described the purposes of technology-based connections including connecting with others, themselves and places important to them; 4. [i]Making connections work[/i] described active strategies to enhance connection.  : Using technology is part of the social engagement of many people. Considering the related feelings of connection and support strategies and needs could enhance future research and practice with older people.  : The different characteristics and potential positive and negative experiences of connection via technology need consideration in measuring social isolation and supporting older adults.
* meiosis
* oocyte
* reproduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674779
}}
==ASL==


===MeSH Terms===
{{medline-entry
-
|title=Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE [[ASL]] MRI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32910547


===Keywords===
Aging; isolation; loneliness; social; social technology


==Validation of the Dépistage Cognitif de Québec in the Oldest Old.==
|keywords=* aging
===Abstract===
* aquaporin-4
We aimed to validate the [i]Dépistage Cognitif de Québec[/i] (DCQ; www.dcqtest.org), a new cognitive screening tool for atypical degenerative syndromes, in the oldest old. The DCQ was developed by expert behavioural neurologists and clinical neuropsychologists based on updated criteria for Alzheimer's disease, primary progressive aphasia, and behavioural variant frontotemporal dementia. It targets five relevant cognitive domains: Memory, Visuospatial, Executive, Language, and Behaviour. Validation was performed using a prospective community-based sample consisting of 53 healthy French-speaking Canadian volunteers aged between 80 and 94 years old. Normative data were derived from participants with no history of cognitive difficulties and a Montreal Cognitive Assessment (MoCA) score ≥ 24. The mean DCQ total score (out of 100) was 84.65 (SD = 6.33). Pearson's correlation coefficient showed a moderate, but significant, correlation ([i]r[/i] = 0.36, [i]p[/i] < .01) with the MoCA. Normative data shown in percentiles were stratified by age and education for DCQ total score and for each of the five cognitive domains. This study suggests that the DCQ is a valid cognitive screening test in the oldest old. It is proposed that the DCQ can help early identification of atypical degenerative syndromes.
* arterial spin labeling
* blood-brain barrier
* blood-brain interface
* water permeability
|full-text-url=https://sci-hub.do/10.1002/mrm.28496
}}
{{medline-entry
|title=Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849217


===MeSH Terms===
-


===Keywords===
|keywords=* MRI
Alzheimer’s disease; aging; atypical dementia; dementia; frontotemporal dementia; normative data; oldest old; test construction; validation
* aging
* arterial spin labeling
* cerebrovascular reactivity
* phase-contrast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411174
}}
{{medline-entry
|title=Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32425745


==Comorbidity Patterns of Older Lung Cancer Patients in Northeast China: An Association Rules Analysis Based on Electronic Medical Records.==
===Abstract===
This study aims to identify the comorbidity patterns of older men with lung cancer in China. We analyzed the electronic medical records (EMRs) of lung cancer patients over age 65 in the Jilin Province of China. The data studied were obtained from 20 hospitals of Jilin Province in 2018. In total, 1510 patients were identified. We conducted a rank-frequency analysis and social network analysis to identify the predominant comorbidities and comorbidity networks. We applied the association rules to mine the comorbidity combination with the values of confidence and lift. A heatmap was utilized to visualize the rules. Our analyses discovered that (1) there were 31 additional medical conditions in older patients with lung cancer. The most frequent comorbidities were pneumonia, cerebral infarction, and hypertension. (2) The network-based analysis revealed seven subnetworks. (3) The association rules analysis provided 41 interesting rules. The results revealed that hypertension, ischemic cardiomyopathy, and pneumonia are the most frequent comorbid combinations. Heart failure may not have a strong implicating role in these comorbidity patterns. Cerebral infarction was rarely combined with other diseases. In addition, glycoprotein metabolism disorder comorbid with hyponatremia or hypokalemia increased the risk of anemia by more than eight times in older lung cancer patients. This study provides evidence on the comorbidity patterns of older men with lung cancer in China. Understanding the comorbidity patterns of older patients with lung cancer can assist clinicians in their diagnoses and contribute to developing healthcare policies, as well as allocating resources.


===MeSH Terms===
|keywords=* BOLD deactivation
-
* aging
* cerebral blood flow
* domain-general
* language fMRI
* semantic fluency
* sensitization
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205008
}}
==ASXL1==


===Keywords===
{{medline-entry
aging; association rules; chronic disease management; comorbidity; lung cancer
|title=[[ASXL1]] mutation in clonal hematopoiesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31945396


==Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells.==
|mesh-terms=* Aged
===Abstract===
* Aging
NADPH oxidases (NOX) are commonly expressed ROS-producing enzymes that participate in the regulation of many signaling pathways, which influence cell metabolism, survival, and proliferation. Due to their high expression in several different types of cancer it was postulated that NOX promote tumor progression, growth, and survival. Thus, the inhibition of NOX activity was considered to have therapeutic potential. One of the possible outcomes of anticancer therapy, which has recently gained much interest, is cancer cell senescence. The induction of senescence leads to prolonged inhibition of proliferation and contributes to tumor growth restriction. The aim of our studies was to investigate the influence of low, non-toxic doses of diphenyleneiodonium chloride (DPI), a potent inhibitor of flavoenzymes including NADPH oxidases, on p53-proficient and p53-deficient HCT116 human colon cancer cells and MCF-7 breast cancer cells. We demonstrated that the temporal treatment of HCT116 and MCF-7 cancer cells (both p53 wild-type) with DPI caused induction of senescence, that was correlated with decreased level of ROS and upregulation of p53/p21 proteins. On the contrary, in the case of p53-/- HCT116 cells, apoptosis was shown to be the prevailing effect of DPI treatment. Thus, our studies provided a proof that inhibiting ROS production, and by this means influencing ROS sensitive pathways, remains an alternative strategy to facilitate so called therapy-induced senescence in cancers.
* Animals
* Clonal Evolution
* Codon, Nonsense
* Hematologic Neoplasms
* Hematopoiesis
* Humans
* Myeloproliferative Disorders
* Neoplasm Proteins
* Repressor Proteins


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1016/j.exphem.2020.01.002
-
}}
==ATF4==


===Keywords===
{{medline-entry
DPI; NADPH oxidases; ROS; apoptosis; cancer; senescence
|title=Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33297752


==Advanced old age as a developmental dilemma: An in-depth comparison of established fourth age conceptualizations.==
===Abstract===
Distinguishing the Fourth Age (FoA) from the Third Age (ThA) has become a common practice in aging research. In this theoretical paper, we focus on four established conceptualizations of the ThA-FoA distinction, i.e., (1) Neugarten's work on the young-old vs. the old-old; (2) Laslett's concept of the innovative life period of the ThA; (3) Erikson's 9th life stage approach; and (4) Baltes' approach considering the FoA as the most radical incompleteness of the human condition. After a comparative descriptive analysis, we extract evaluative elements inherent in the four approaches according to six categories: (1) fundamental values; (2) positive evaluative elements; (3) negative evaluative elements; (4) the decline vs. growth view; (5) the continuity vs. discontinuity view; and (6) values related to practical issues. As an overarching result of our analysis, we conclude that all conceptions face - in different ways - dilemmas that seem difficult to solve. One option may be to give up all ambitions toward agency for the FoA and indeed qualify this phase as the "aging without agency" phase of life. Doing so, however, seems ethically questionable, because it would give up acknowledged values connected with a good human life such as human goal-directed autonomy and freedom. In conclusion, the ThA-FoA distinction, although arguably a needed and helpful roadmap for the recent decades of aging science, comes with enduring disadvantages and eventually even risks. Therefore, in future aging science, we recommend avoiding the ThA-FoA distinction or at least using it only in combination with a critical attitude.


===MeSH Terms===
|keywords=* aging
-
* arteries
* endoplasmic reticulum
* vascular calcification
* warfarin
|full-text-url=https://sci-hub.do/10.1161/ATVBAHA.120.315506
}}
==ATF6==


===Keywords===
{{medline-entry
Agency and aging; Ethics of aging; Fourth age; Third age; Young-old vs. old-old
|title=Cellular proteostasis decline in human senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257563


==Photoacclimation to high-light stress in Chlamydomonas reinhardtii during conditional senescence relies on generating pH-dependent, high-quenching centres.==
===Abstract===
Microalgae can respond to long-term increases in light intensity by altering the concentration of photosynthetic complexes. Under active growth, the ability of Chlamydomonas reinhardtii to acclimate to excess light is dependent on cell division to reduce the concentration of photosynthetic complexes. But, in batch culture, cells eventually reach stationary phase where their ability to divide is limited; this should impact their capacity to undergo photoacclimation. Our goal is to dissect excess-light responses as cells approach stationary phase and to determine how the strategies of photoacclimation differ compared to cells in the exponential-growth phase. In this study, cultures exited exponential growth and transitioned into a declining growth phase (DGP), where cells continued a slow rate of growth for the next seven days in both low (LL) and high-light (HL). During this period, both cultures experience a conditional senescence-related decline in chlorophyll levels. Under HL, however, the senescing cultures have a rapid decline in PSII reaction centres, maintain a stable concentration of LHCII antenna, rapidly increase LHCSR levels, and have a sustained increase in Fo/Fm. Collectively this implies that the remaining antenna act as pH-dependent, quenching centres, presumably to protect the senescing chloroplast against HL. We discovered that acclimating to HL post-exponential phase involves active degradation that is intertwined with the normal senescence process that allowed for a limited rate of cell division.


===MeSH Terms===
|keywords=* UPR
-
* chaperones
* heat shock response
* protein homeostasis
* senescence
|full-text-url=https://sci-hub.do/10.1073/pnas.2018138117
}}
{{medline-entry
|title=Impact of endoplasmic reticulum stress on oocyte aging mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32514562


===Keywords===
Autophagy; Chlamydomonas; Conditional senescence; LHCSR; NPQ; Photoacclimation


==Characterizing Experiences of Conversion Therapy Among Middle-Aged and Older Men Who Have Sex with Men from the Multicenter AIDS Cohort Study (MACS).==
|keywords=* ER stress
===Abstract===
* GRP78
Conversion therapies are practices that attempt to change an individuals' same-sex attractions through psychotherapeutic and aversive therapeutic techniques. Conversion therapies were developed based on homophobic beliefs that same-sex attractions are a mental illness. We sought to describe the prevalence and characteristics of conversion therapy experienced among middle-aged and older men who have sex with men in the United States. Given associations of homophobic stigma and HIV risk, we hypothesized that HIV-positive men would report higher odds of conversion therapy compared to HIV-negative men. We analyzed data from 1,237 middle-aged and older MSM enrolled in the Multicenter AIDS Cohort Study. Among participants, 17.7% reported lifetime conversion therapy, of which the average start of therapy age was 22.67 ([i]sd[/i] = 10.56) years, 25.8% reported therapy durations of 6+ months, 37.7% reported session frequencies 1+ session per week, and 35.9% indicated that undergoing therapy was either a little or not at all their decision. We observed no statistically significant association between reporting lifetime conversion therapy and HIV status. Future efforts should continue to assess the magnitude of harm conversion therapies impose on MSM's health across the life course as well as test potential, indirect associations that may link these practices to HIV.
* PERK
* eIF2α
* endoplasmic reticulum
* mouse oocyte
* oocyte aging
* salubrinal
|full-text-url=https://sci-hub.do/10.1093/molehr/gaaa040
}}
{{medline-entry
|title=ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279085


===MeSH Terms===
-


===Keywords===
|keywords=* Ageing
Aging; Conversion Therapy; Gay and Bisexual Men; HIV; Stigma
* Immunometabolism
* Immunosenescence
* Immunosuppression
* Inflammaging
* Neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220864
}}
{{medline-entry
|title=Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31972978


==The Process of Creating and Disseminating Exercise Programs by Physical Therapists for Older Adults With Chronic Back Pain.==
===Abstract===
The purpose of this study was to enhance the understanding of the process that physical therapists undertake when creating and disseminating exercise programs for older adults with chronic back pain. Constructivist grounded theory methodology was used as an accessible mode of researching pragmatic clinical practices. Physical therapists from outpatient, ambulatory care clinic settings participated in in-depth, individual interviews (n = 9) and in-clinic observations (n = 5). Data collection and analysis were iterative processes. Codes were generated based on recurrent themes, and constant comparative analysis was used to compare data. Analysis and data collection were concluded when theoretical sufficiency was reached. Physical therapist participants described the process of creating and implementing exercise plans as involving listening to the patient's story, determining function, physical therapy care, supported integration, and, ultimately, returning back to living and life with chronic back pain. Participants worked through the 5 phases at different rates, often recurrently, when treating older adults with chronic back pain. The phases are positioned within a shared alliance between physiotherapy provider and patient, with a transfer of responsibility occurring throughout treatment and follow-up sessions, progressing toward patient independence. This transfer of responsibility served as the core category for the process herein. This research highlights the importance of listening to patients' stories when engaging in physical therapy care. Focusing on function, providing education and exercise as components of care, and supporting integration of exercise into everyday life are considerations for providing care for older adults with chronic back pain in physical therapist practice, and, ultimately, for returning to life. With aging populations and with the increasing prevalence of chronic conditions, this research offers insight into a process for physical therapists to enact exercise engagement for improved health and quality of life for older adults with chronic back pain.


===MeSH Terms===
|keywords=* ER stress response
-
* Golgi apparatus/complex stress response
* SASP
* immunosenescence
* klotho
* monocytes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072557
}}
==ATG3==


===Keywords===
{{medline-entry
Aging; Back Pain; Chronic Pain; Exercise; Older Adults; Physical Activity
|title=Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32244623


==Aging and leukemic evolution of hematopoietic stem cells under various stress conditions.==
===Abstract===
Hematopoietic stem cells (HSCs) have self-renewal capacity and differentiation potential into all lineages of blood cells throughout the lifetime of an organism. The function of HSCs gradually changes during aging. To date, various stress factors influencing HSC aging have been identified. The increased production of reactive oxygen species and DNA damage responses are causatively attributed to HSC aging. The increased apolarity is a prominent feature of aged HSCs, whereas it is less obvious in young HSCs. The bone marrow (BM) microenvironment niche is a crucial factor for HSC aging. Mesenchymal stem cells show skewed differentiation during aging, which leads to decreased bone formation and increased adipogenesis. The accumulation of adipocytes confers negative effects on hematopoiesis. Loss of sympathetic nerve fibers or adrenoreceptor β3 signaling induces premature HSC and niche aging. Epigenetic regulators such as polycomb group proteins and the sirtuin family of proteins act to prevent premature aging. Targeting these factors, several rejuvenation strategies for aged HSCs have been employed in mice. However, we still do not know whether these strategies can be extrapolated to human HSCs. Aging is frequently accompanied by the development of clonal hematopoiesis, which is called age-related clonal hematopoiesis (ARCH) or clonal hematopoiesis of indeterminate potential (CHIP). Most ARCH/CHIP mutations occur in genes encoding epigenetic regulators including DNMT3A, TET2, and ASXL1, which suggests the relevance of epigenetic drift during the aging process. ARCH/CHIP is a strong risk factor for subsequent hematologic cancer. Notably, it also has an impact on the development of non-malignant disorders such as coronary heart disease. Further studies are warranted to decipher the complete picture of molecular crosstalk that regulates HSC aging.


===MeSH Terms===
|keywords=* Estrogen
-
* MCF-7
* MDA-MB-231
* autophagy
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235898
}}
==ATG5==


===Keywords===
{{medline-entry
Age-related clonal hematopoiesis; Aging; Clonal hematopoiesis of indeterminate potential; DNA damage; Epigenetics; Hematopoietic stem cell; Polarity; Reactive oxygen species; Senescence; Stem cell niche
|title=Autophagy and heat-shock response impair stress granule assembly during cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049246


==Modeling Retest Effects in a Longitudinal Measurement Burst Study of Memory.==
===Abstract===
Longitudinal designs must deal with the confound between increasing age and increasing task experience (i.e., retest effects). Most existing methods for disentangling these factors rely on large sample sizes and are impractical for smaller scale projects. Here, we show that a measurement burst design combined with a model of retest effects can be used to study age-related change with modest sample sizes. A combined model of age-related change and retest-related effects was developed. In a simulation experiment, we show that with sample sizes as small as [i]n[/i] = 8, the model can reliably detect age effects of the size reported in the longitudinal literature while avoiding false positives when there is no age effect. We applied the model to data from a measurement burst study in which eight subjects completed a burst of seven sessions of free recall every year for five years. Six additional subjects completed a burst only in years 1 and 5. They should, therefore, have smaller retest effects but equal age effects. The raw data suggested slight improvement in memory over five years. However, applying the model to the yearly-testing group revealed that a substantial positive retest effect was obscuring stability in memory performance. Supporting this finding, the control group showed a smaller retest effect but an equal age effect. Measurement burst designs combined with models of retest effects allow researchers to employ longitudinal designs in areas where previously only cross-sectional designs were feasible.


===MeSH Terms===
|keywords=* Ageing
-
* Cellular senescence
* Molecular biology
* Oxidative stress
* Stress granules
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111382
}}
==ATG7==


===Keywords===
{{medline-entry
aging; free recall; memory models; practice effects; stability
|title=Age-related impairment of autophagy in cervical motor neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33290859


==Reactive, Agentic, Apathetic, or Challenged? Aging, Emotion, and Coping During the COVID-19 Pandemic.==
===Abstract===
Advanced age is generally associated with improved emotional well-being, but the COVID-19 pandemic unleashed a global stressor that gravely threatened the physical well-being and ostensibly challenged the emotional well-being of older adults disproportionately. The current study investigated differences in emotional experiences and coping strategies between younger and older adults during the pandemic, and whether these differences were accounted for by age differences in appraisal of the pandemic. We asked younger (n = 181) and older adult (n = 176) participants to report their stress, appraisals the pandemic, emotions, and the ways in which they were coping with the pandemic. Results indicated that older adults experienced less stress and less negative affect and used greater problem-focused coping and less avoidant coping in response to the pandemic than younger adults. Further, age differences in affect and coping were partially accounted for by age differences in appraisals of the pandemic. Despite their objectively higher risk of illness and death due to the pandemic, older adults experienced less negative affect and used more agentic coping strategies than younger adults.


===MeSH Terms===
|keywords=* Aging
-
* Autophagy
* Motor neuron
* Neuromuscular dysfunction
* Spinal cord
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111193
}}
{{medline-entry
|title=Comprehensive Bioinformatics Identifies Key microRNA Players in [[ATG7]]-Deficient Lung Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32527064


===Keywords===
affect; aging; appraisal; chronic stress; emotion regulation


==Aligning social and health care services: The case of Community Care Connections.==
|keywords=* autophagy
===Abstract===
* bioinformatics
The Community Care Connections (CCC) program aims to align social and healthcare services to improve health outcomes in older adults with complex medical and social needs. This study assessed changes in healthcare utilization before and after CCC program participation. Between June 2016 and March 2019, 1214 adults with complete data who provided informed consent participated in the CCC program. CCC client data were linked with data on hospitalizations, emergency department (ED) visits, and observation stays 90 days before and after program start. Data analysis examined changes in health care utilization 90 days after program start, compared to 90 days before. Hospitalizations decreased by 30% (Change = -0.029, 95% Confidence Interval (CI) = -0.053, -0.005), ED visits decreased by 29% (Change = -0.114, 95% CI = -0.163, -0.066), and observation stays decreased by 23% (Change = -0.041, 95% CI = -0.073, -0.009) during the post period. ED visits decreased by 37% (Change = -0.140, 95% CI = -0.209, -0.070) for those with hypertension and by 30% (Change = -0.109, 95% CI = -0.199, -0.020) for those with high cholesterol, while observation stays decreased by 46% (Change = -0.118, 95% CI = -0.185, -0.052) for those with diabetes and by 44% (Change = -0.082, 95% CI = -0.150, -0.014) for those with high cholesterol during the post period. Connecting older adults with social services through the healthcare delivery system may lead to decreases in hospitalizations, ED visits, and observation stays. Implementation of cross-sector partnerships that address non-clinical factors that impact the health of older adults may reduce the use of costly healthcare services.
* functional network analysis
* lung fibrosis
* miR
* proteomics
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312768
}}
{{medline-entry
|title=Regulation of autophagy by DNA G-quadruplexes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32420812


===MeSH Terms===
-


===Keywords===
|keywords=* G-quadruplex
Aging services; Healthcare utilization; Population health; Program evaluation; Social determinants; Social services
* aging
* astrocytes
* autophagy
* neurodegeneration
* neurons
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1769991
}}
{{medline-entry
|title=[[ATG7]] is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31880208


==Analysis of Stored mRNA Degradation in Acceleratedly Aged Seeds of Wheat and Canola in Comparison to Arabidopsis.==
===Abstract===
Seed aging has become a topic of renewed interest but its mechanism remains poorly understood. Our recent analysis of stored mRNA degradation in aged Arabidopsis seeds found that the stored mRNA degradation rates (estimated as the frequency of breakdown per nucleotide per day or [i]β[/i] value) were constant over aging time under stable conditions. However, little is known about the generality of this finding to other plant species. We expanded the analysis to aged seeds of wheat ([i]Triticum aestivum[/i]) and canola ([i]Brassica napus[/i]). It was found that wheat and canola seeds required much longer periods than Arabidopsis seeds to lose seed germination ability completely under the same aging conditions. As what had been observed for Arabidopsis, stored mRNA degradation (∆Ct value in qPCR) in wheat and canola seeds correlated linearly and tightly with seed aging time or mRNA fragment size, while the quality of total RNA showed little change during seed aging. The generated [i]β[/i] values reflecting the rate of stored mRNA degradation in wheat or canola seeds were similar for different stored mRNAs assayed and constant over seed aging time. The overall [i]β[/i] values for aged seeds of wheat and canola showed non-significant differences from that of Arabidopsis when aged under the same conditions. These results are significant, allowing for better understanding of controlled seed aging for different species at the molecular level and for exploring the potential of stored mRNAs as seed aging biomarkers.


===MeSH Terms===
|keywords=* ATG7
-
* Aging
* ameloblast
* autophagy
* epithelium
* ferritin
* hyperplasia
* iron
* secretion
* tooth
|full-text-url=https://sci-hub.do/10.1080/15548627.2019.1709764
}}
{{medline-entry
|title=Enhancing Autophagy Diminishes Aberrant Ca  Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636573


===Keywords===
canola; real-time quantitative PCR (qPCR); seed aging; seed germination; seed longevity; stored mRNA degradation; wheat; β value


==[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]==
|keywords=* aging
===Abstract===
* autophagy
Night work provides biorhythms desynchronization, disorder of melatonin-producing function and accelerated pineal gland aging. One of the promising geroprotectors restoring the pineal melatonin synthesis is the AEDG (Ala-Glu-Asp-Gly) peptide. AEDG peptide increases in 1,7 times the 6-sulfatoxymelatonin (6-SOMT) excretion in the urine of middle-aged people. Moreover, AEDG peptide normalized circadian Clock and Csnk1e genes hyper expression in leukocytes in 1,9-2,1 times and increases the Cry2 gene hypo expression in peripheral blood lymphocytes in 2 times in people with reduced melatonin-producing epiphysis function. The geroprotective effect of the AEDG peptide is based on its ability to restore the epiphysis melatonin-producing function by means regulation of human circadian genes expression.
* calcium
* cardiac physiology
* ryanodine receptor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787934
}}
==ATM==


===MeSH Terms===
{{medline-entry
-
|title=S[[ATM]]F Suppresses the Premature Senescence Phenotype of the [[ATM]] Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143308


===Keywords===
AEDG peptide; accelerated aging; circadian genes; melatonin; pineal gland


==Dietary protein intake and circulating advanced glycation end product/receptor for advanced glycation end product concentrations in the Health, Aging, and Body Composition Study.==
|keywords=* ATM
===Abstract===
* DNA damage
Advanced glycation end products (AGEs) promote adverse health effects and may contribute to the multi-system functional decline observed in aging. Diet is a major source of AGEs, and foods high in protein may increase circulating AGE concentrations. However, epidemiological evidence that high-protein diets increase AGEs is lacking. We examined whether dietary protein intake was associated with serum concentrations of the major AGE carboxymethyl-lysine (CML) and the soluble receptor for AGEs (sRAGE) in 2439 participants from the Health, Aging, and Body Composition study (mean age, 73.6 ± 2.9 y; 52% female; 37% black). CML and sRAGE were measured by ELISA, and the CML/sRAGE ratio was calculated. Protein intake was estimated using an interviewer-administered FFQ and categorized based on current recommendations for older adults: <0.8 g/kg/d (n = 1077), 0.8 to <1.2 g/kg/d (n = 922), and ≥1.2 g/kg/d (n = 440). Associations between protein intake and AGE-RAGE biomarkers were examined using linear regression models adjusted for demographics, height, lifestyle behaviors, prevalent disease, cognitive function, inflammation, and other dietary factors. CML concentrations were higher in individuals with higher total protein intake (adjusted least squares mean ± SE: <0.8 g/kg/d, 829 ± 17 ng/ml; 0.8 to <1.2 g/kg/d, 860 ± 15 ng/ml; ≥1.2 g/kg/d, 919 ± 23 ng/ml; P for trend = 0.001), as were sRAGE concentrations (<0.8 g/kg/d, 1412 ± 34 pg/ml; 0.8 to <1.2 g/kg/d, 1479 ± 31 pg/ml; ≥1.2 g/kg/d, 1574 ± 47 pg/ml; P for trend < 0.0001). Every 0.1 g/kg/d increment in total protein intake was associated with a 13.3 ± 3.0 ng/ml increment in CML and a 22.1 ± 6.0 pg/ml increment in sRAGE (P < 0.0001 for both). Higher CML and sRAGE concentrations were also associated with higher intakes of both animal and vegetable protein (all P values ≤ 0.01). There were no significant associations with the CML/sRAGE ratio. Higher dietary protein intake was associated with higher CML and sRAGE concentrations in older adults; however, the CML/sRAGE ratio remained similar across groups.
* SATMF
* fertility
* leaf senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662627
}}
{{medline-entry
|title=[[ATM]] mediated-p53 signaling pathway forms a novel axis for senescence control.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949791


===MeSH Terms===
-


===Keywords===
|keywords=* ATM inhibition
advanced glycation end products; aging; chronic kidney disease; dietary protein; soluble receptor for advanced glycation end products; type 2 diabetes
* Metabolic reprogrammer
* Mitochondria
* P53
* Senescence alleviation
|full-text-url=https://sci-hub.do/10.1016/j.mito.2020.09.002
}}
{{medline-entry
|title=Non-canonical [[ATM]]/MRN activities temporally define the senescence secretory program.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785991


==Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.==
===Abstract===
Cellular senescence is a stable cell cycle arrest induced by diverse triggers, including replicative exhaustion, DNA damaging agents, oncogene activation, oxidative stress, and chromatin disruption. With important roles in aging and tumor suppression, cellular senescence has been implicated also in tumor promotion. Here we show that certain multiwalled carbon nanotubes (MWCNTs), as fiber-like nanomaterials, can trigger cellular senescence in primary human mesothelial cells. Using in vitro approaches, we found manifestation of several markers of cellular senescence, especially after exposure to a long and straight MWCNT. These included inhibition of cell division, senescence-associated heterochromatin foci, senescence-associated distension of satellites, LMNB1 depletion, γH2A.X nuclear panstaining, and enlarged cells exhibiting senescence-associated β-galactosidase activity. Furthermore, genome-wide transcriptome analysis revealed many differentially expressed genes, among which were genes encoding for a senescence-associated secretory phenotype. Our results clearly demonstrate the potential of long and straight MWCNTs to induce premature cellular senescence. This finding may find relevance in risk assessment of workplace safety, and in evaluating MWCNT's use in medicine such as drug carrier, due to exposure effects that might prompt onset of age-related diseases, or even carcinogenesis.


===MeSH Terms===
|keywords=* DNA damage response
-
* MRN complex
* NF-κB
* chromatin
* senescence secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534619
}}
{{medline-entry
|title=[[ATM]] is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201398


===Keywords===
alpha tubulin; cellular senescence; mesothelial cells; microarray analysis; multiwalled carbon nanotubes; γH2A.X


==Effect of cellular and ECM aging on human iPSC-derived cardiomyocyte performance, maturity and senescence.==
|keywords=* ATM
===Abstract===
* DNA damage response
Cardiovascular diseases are the leading cause of death worldwide and their occurrence is highly associated with age. However, lack of knowledge in cardiac tissue aging is a major roadblock in devising novel therapies. Here, we studied the effects of cell and cardiac extracellular matrix (ECM) aging on the induced pluripotent stem cell (iPSC)-derived cardiomyocyte cell state, function, as well as response to myocardial infarction (MI)-mimicking stress conditions in vitro. Within 3-weeks, young ECM promoted proliferation and drug responsiveness in young cells, and induced cell cycle re-entry, and protection against stress in the aged cells. Adult ECM improved cardiac function, while aged ECM accelerated the aging phenotype, and impaired cardiac function and stress defense machinery of the cells. In summary, we have gained a comprehensive understanding of cardiac aging and highlighted the importance of cell-ECM interactions. This study is the first to investigate the individual effects of cellular and environmental aging and identify the biochemical changes that occur upon cardiac aging.
* NF-κB
* aging
* cellular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138542
}}
{{medline-entry
|title=[[ATM]] suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163596


===MeSH Terms===
-


===Keywords===
|keywords=*
Cardiac aging; Cardiac tissue engineering; Decellularized extracellular matrix; Human induced pluripotent stem cell-derived cardiomyocyte; Hypoxia; Myocardial infarction
Arabidopsis thaliana


==Older People's Use and Nonuse of the Internet in Sweden.==
* ATM
===Abstract===
* DNA repair
The use of the internet has considerably increased over recent years, and the importance of internet use has also grown as services have gone online. Sweden is largely an information society like other countries with high reported use amongst European countries. In line with digitalization development, society is also changing, and many activities and services today take place on the internet. This development could potentially lead to those older persons who do not use the internet or do not follow the development of services on the internet finding it difficult to take part in information and activities that no longer occur in the physical world. This has led to a digital divide between groups, where the older generations (60+), in particular, have been affected. In a large study of Sweden's adult population in 2019, 95 percent of the overall population was said to be internet users, and the corresponding number for users over 66 years of age was 84%. This study shows that the numbers reported about older peoples' internet use, most likely, are vastly overestimated and that real use is significantly lower, especially among the oldest age groups. We report that 62.4% of the study subjects are internet users and that this number most likely also is an overestimation. When looking at nonresponders to the questionnaire, we find that they display characteristics generally attributed to non-use, such as lower education, lower household economy, and lower cognitive functioning.
* double-strand breaks
* histone methylation
* leaf senescence
|full-text-url=https://sci-hub.do/10.1111/nph.16535
}}
{{medline-entry
|title=Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098270


===MeSH Terms===
|mesh-terms=* Ataxia Telangiectasia Mutated Proteins
-
* Axitinib
* Cell Line, Tumor
* Cellular Senescence
* Coculture Techniques
* Gene Expression Profiling
* Glioblastoma
* Human Umbilical Vein Endothelial Cells
* Humans
* Phosphorylation
|keywords=* Axitinib
* endothelial cells
* glioblastoma
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073100
}}
{{medline-entry
|title=Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31916095


===Keywords===
aging; gerontechnology; internet; usage


==P53 induces senescence in the unstable progeny of aneuploid cells.==
|keywords=* Aging
===Abstract===
* DNA fragmentation
Aneuploidy is the condition of having an imbalanced karyotype, which is associated with tumor initiation, evolution, and acquisition of drug-resistant features, possibly by generating heterogeneous populations of cells with distinct genotypes and phenotypes. Multicellular eukaryotes have therefore evolved a range of extrinsic and cell-autonomous mechanisms for restraining proliferation of aneuploid cells, including activation of the tumor suppressor protein p53. However, accumulating evidence indicates that a subset of aneuploid cells can escape p53-mediated growth restriction and continue proliferating [i]in vitro[/i]. Here we show that such aneuploid cell lines display a robust modal karyotype and low frequency of chromosomal aberrations despite ongoing chromosome instability. Indeed, while these aneuploid cells are able to survive for extended periods [i]in vitro[/i], their chromosomally unstable progeny remain subject to p53-induced senescence and growth restriction, leading to subsequent elimination from the aneuploid pool. This mechanism helps maintain low levels of heterogeneity in aneuploid populations and may prevent detrimental evolutionary processes such as cancer progression and development of drug resistance.
* Gene expression
* Sperm
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065969
}}
{{medline-entry
|title=BRCA-related [[ATM]]-mediated DNA double-strand break repair and ovarian aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822904


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Ataxia Telangiectasia
* BRCA1 Protein
* BRCA2 Protein
* DNA Breaks, Double-Stranded
* DNA Repair
* Female
* Fertility
* Fertility Preservation
* Humans
* Mice
* Oocytes
* Ovarian Follicle
* Ovarian Reserve
* Ovary
|keywords=*
          BRCA
       
*
          BRCA1/2
       
* DNA repair
* anti-Mullerian hormone
* chemotherapy
* mutations
* oocyte
* ovarian aging
* ovarian reserve
* ovarian response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935693
}}
{{medline-entry
|title=[[ATM]] Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781094


===Keywords===
|mesh-terms=* Anti-Retroviral Agents
P53; aneuploidy; genome instability; senescence
* Ataxia Telangiectasia Mutated Proteins
* Cellular Senescence
* DNA Damage
* HIV Infections
* Humans
* T-Lymphocytes
* Telomere
|keywords=* ATM
* DNA damage repair
* HIV
* T cell homeostasis
* apoptosis
* immune aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856652
}}
{{medline-entry
|title=SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565865


==Asiatic acid protects oocytes against [i]in vitro[/i] aging-induced deterioration and improves subsequent embryonic development in pigs.==
|mesh-terms=* Animals
===Abstract===
* Ataxia Telangiectasia Mutated Proteins
As a pentacyclic triterpene in [i]Centella asiatica[/i], asiatic acid (AA) is a powerful antioxidant with many bioactivities. In the present research, we investigated whether AA has the potential to rescue the decrease in porcine oocyte quality that occurs during [i]in vitro[/i] aging (IVA). Mature porcine oocytes were collected and then continuously cultured for an additional 24 h or 48 h with or without AA in maturation medium as an IVA model. The results revealed that AA supplementation reduced the percentage of abnormal aged porcine oocytes during IVA. Furthermore, AA supplementation effectively maintained aged porcine oocyte developmental competence, both parthenogenetic activation and [i]in vitro[/i] fertilization. The number of sperm that bound to the zona pellucida on aged porcine oocytes was higher in the AA-supplemented group than in the non-supplemented group. Moreover, AA supplementation not only blocked IVA-induced oxidative stress but also maintained intracellular GSH levels and reduced the percentage of early apoptosis aged porcine oocytes. Mitochondrial functions were disordered during the IVA process. The intracellular ATP levels and mitochondrial membrane potential in aged porcine oocytes were dramatically increased by AA supplementation. Therefore, AA has beneficial effects on porcine oocyte quality and developmental potential maintenance during IVA.
* Carcinogenesis
* Cells, Cultured
* DNA Damage
* Embryo, Mammalian
* Fibroblasts
* Gamma Rays
* Hematologic Neoplasms
* Heterozygote
* Kaplan-Meier Estimate
* Longevity
* Lymphoma
* Mice, Inbred C57BL
* Mice, Knockout
* Oxidative Stress
* Protein-Serine-Threonine Kinases
|keywords=* DNA damage
* cancer
* inflammation
* lymphoma
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850945
}}
{{medline-entry
|title=LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444317


===MeSH Terms===
|mesh-terms=* Cell Proliferation
-
* Cellular Senescence
* Fibroblasts
* Heterogeneous-Nuclear Ribonucleoprotein Group F-H
* Humans
* MicroRNAs
* RNA, Long Noncoding
* Skin
* Skin Aging
* Ultraviolet Rays
|keywords=* cellular senescence
* dermal fibroblast
* lncRNA
* microRNA
* ultraviolet B
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738423
}}
{{medline-entry
|title=Tel1/[[ATM]] Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391264


===Keywords===
|mesh-terms=* Amino Acid Substitution
asiatic acid; early embryonic development; oocyte aging; oxidative stress; pig
* Ataxia Telangiectasia Mutated Proteins
* Cell Cycle Checkpoints
* Cell Division
* Cellular Senescence
* DNA Damage
* DNA Replication
* DNA, Single-Stranded
* DNA-Binding Proteins
* Intracellular Signaling Peptides and Proteins
* Mutant Proteins
* Protein-Serine-Threonine Kinases
* Saccharomyces cerevisiae
* Saccharomyces cerevisiae Proteins
* Telomerase
* Telomere
* Telomere Shortening
|keywords=* Tel1
* checkpoint
* replicative senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781906
}}
==ATP7A==


==Family care across diverse cultures: Re-envisioning using a transnational lens.==
{{medline-entry
===Abstract===
|title=Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.
In an increasingly globalized world, the importance of developing a more culturally complex understanding of family care has been clearly identified. This study explored family care across three different cultural groups - Chinese, South Asian, and Latin American - living in a metropolitan, Pacific-West, Canadian city. In-depth qualitative interviews were conducted with 29 family members from one of the three family groups exploring how they practiced 'care' for their aging, often frail, relatives. The importance of conceptualizing family care as a transnational, collective undertaking emerged from the outset as critical for understanding care practices in all three cultural communities. Three themes identified contributed to this conceptualization: the need to broaden the understanding of family care; the centrality of geographic mobility, and the need to rethink the location of aging and consider its relationship to mobility; and the use of technology by extended family networks to facilitate continuity and connection. An over-riding notion of 'flow' or fluid movement, rather than a fixed, static arrangement, emerged as critical for understanding family care. This perspective challenges the dominant approach to studying family care in gerontology that generally conceptualizes family care practice as one local primary caregiver, often female, with some support from other family members. Understanding family care from a transnational lens builds support for the importance of a feminist Ethics of Care lens and has important implications for policy and service delivery practices.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396659


===MeSH Terms===
|mesh-terms=* 3T3-L1 Cells
-
* Adipocytes
* Adipose Tissue, White
* Aging
* Animals
* Body Weight
* Copper
* Copper-Transporting ATPases
* Diet, High-Fat
* Energy Metabolism
* Insulin Resistance
* Lipid Metabolism
* Lipodystrophy
* Lipolysis
* Mice
* Mice, Knockout
|keywords=* ATP7A
* Adipose tissues
* Copper
* Insulin resistance
* Lipoatrophy
|full-text-url=https://sci-hub.do/10.1007/s00125-019-4966-2
}}
==ATR==


===Keywords===
{{medline-entry
Culture; Ethics of care; Family care; Flow of care; Technology; Transnational aging
|title=Bloodstain age estimation through infrared spectroscopy and Chemometric models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33077037


==Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.==
===Abstract===
Lung ultrasound (LUS) showed a promising role in the diagnosis and monitoring of patients hospitalized for novel coronavirus disease (COVID-19). However, no data are available on its role in elderly patients. The aim of this study was to evaluate the diagnostic and prognostic role of LUS in elderly patients hospitalized for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pneumonia. Consecutive elderly patients (age >65 years) hospitalized for COVID-19 were enrolled. Demographics, laboratory, comorbidity, and the clinical features of the patients were collected. All patients underwent LUS on admission to the ward. LUS characteristics have been analyzed. Uni- and multivariate analyses to evaluate predictors for in-hospital death were performed. Thirty-seven hospitalized elderly patients (19 men) with a diagnosis of SARS-CoV-2 infection were consecutively enrolled. The median age was 82 years (interquartile range 74.5-93.5). Ultrasound alterations were found in all patients enrolled; inhomogeneous interstitial syndrome with spared areas (91.9%) and pleural alterations (100%) were the most frequent findings. At univariate analysis, LUS score (hazard ratio [HR] 1.168, 95% CI 1.049-1.301) and pleural effusions (HR 3.995, 95% CI 1.056-15.110) were associated with in-hospital death. At multivariate analysis, only LUS score (HR 1.168, 95% CI 1.049-1.301) was independelty associated with in-hospital death. The LUS score's best cutoff for distinguishing patients experiencing in-hospital death was 17 (at multivariate analysis LUS score ≥17, HR 4.827, 95% CI 1.452-16.040). In-hospital death was significantly different according to the LUS score cutoff of 17 (p = 0.0046). LUS could play a role in the diagnosis and prognosis in elderly patients hospitalized for SARS-CoV-2 infection.


===MeSH Terms===
|keywords=* Aging
-
* Bloodstains
* Chemometric
* Forensic chemistry
* MLR
* PLSR
|full-text-url=https://sci-hub.do/10.1016/j.scijus.2020.07.004
}}
{{medline-entry
|title=Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887052


===Keywords===
Aging; Coronavirus disease; Elderly; Lung ultrasound; Severe acute respiratory syndrome-coronavirus-2


==Stressful development: Integrating endoderm development, stress, and longevity.==
|keywords=* ANN
===Abstract===
* Artificial neural networks
In addition to performing digestion and nutrient absorption, the intestine serves as one of the first barriers to the external environment, crucial for protecting the host from environmental toxins, pathogenic invaders, and other stress inducers. The gene regulatory network (GRN) governing embryonic development of the endoderm and subsequent differentiation and maintenance of the intestine has been well-documented in C. elegans. A key regulatory input that initiates activation of the embryonic GRN for endoderm and mesoderm in this animal is the maternally provided SKN-1 transcription factor, an ortholog of the vertebrate Nrf-1 and -2, which, like C. elegans SKN-1, perform conserved regulatory roles in mediating a variety of stress responses across metazoan phylogeny. Other key regulatory factors in early gut development also participate in stress response as well as in innate immunity and aging and longevity. In this review, we discuss the intersection between genetic nodes that mediate endoderm/intestine differentiation and regulation of stress and homeostasis. We also consider how direct signaling from the intestine to the germline, in some cases involving SKN-1, facilitates heritable epigenetic changes, allowing transmission of adaptive stress responses across multiple generations. These connections between regulation of endoderm/intestine development and stress response mechanisms suggest that varying selective pressure exerted on the stress response pathways may influence the architecture of the endoderm GRN, thereby leading to genetic and epigenetic variation in early embryonic GRN regulatory events.
* FTIR
* LDA
* Linear discriminant analysis
* Lubricant oil aging
|full-text-url=https://sci-hub.do/10.1016/j.talanta.2020.121312
}}
{{medline-entry
|title=Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32883016


===MeSH Terms===
-


===Keywords===
|keywords=* ATM
Caenorhabditis elegans; Embryonic development; Epigenetics inheritance; Innate immunity; Longevity; Pleiotropy; Stress
* ATR
* DNA damage response inhibitor
* DNAPK
* HNSCC
* homologous recombination
* ionizing radiation
* kinase inhibitor
* radiosensitivity
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563880
}}
{{medline-entry
|title=Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32775731


==Cause and effect in epigenetics - where lies the truth, and how can experiments reveal it? Epigenetic self-reinforcing loops obscure causation in cancer and aging.==
===Abstract===
Epigenetic changes are implicated in aging and cancer. Sometimes, it is clear whether the causing agent of the condition is a genetic factor or epigenetic. In other cases, the causative factor is unclear, and could be either genetic or epigenetic. Is there a general role for epigenetic changes in cancer and aging? Here, I present the paradigm of causative roles executed by epigenetic changes. I discuss cases with clear roles of the epigenome in cancer and aging, and other cases showing involvement of other factors. I also present the possibility that sometimes causality is difficult to assign because of the presence of self-reinforcing loops in epigenetic regulation. Such loops hinder the identification of the causative factor. I provide an experimental framework by which the role of the epigenome can be examined in a better setting and where the presence of such loops could be investigated in more detail.


===MeSH Terms===
|keywords=* Activation energy
-
* Aging
* Bioethanol fuel
* Kinetics analysis
* Lifetime prediction
* Materials chemistry
* Materials science
* Poly(vinylidene fluoride)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398943
}}
{{medline-entry
|title=Supraphysiological protection from replication stress does not extend mammalian lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253367


===Keywords===
aging; cancer; causality; epigenetics; histone modification; methylation; self reinforcing loops


==Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice.==
|keywords=* DNA damage
===Abstract===
* aging
TGR5, a G protein-coupled bile acid receptor, is expressed in various tissues and regulates several physiological processes. In the skeletal muscle, TGR5 activation is known to induce muscle hypertrophy; however, the effects on glucose and lipid metabolism are not well understood, despite the fact that the skeletal muscle plays a major role in energy metabolism. Here, we demonstrate that skeletal muscle-specific TGR5 transgenic (Tg) mice exhibit increased glucose utilization, without altering the expression of major genes related to glucose and lipid metabolism. Metabolite profiling analysis by CE-TOF MS showed that glycolytic flux was activated in the skeletal muscle of Tg mice, leading to an increase in glucose utilization. Upon long-term, high-fat diet (HFD) challenge, blood glucose clearance was improved in Tg mice without an accompanying increase in insulin sensitivity in skeletal muscle and a reduction of body weight. Moreover, Tg mice showed improved age-associated glucose intolerance. These results strongly suggest that TGR5 ameliorated glucose metabolism disorder that is caused by diet-induced obesity and aging by enhancing the glucose metabolic capacity of skeletal muscle. Our study demonstrates that TGR5 activation in the skeletal muscle is effective in improving glucose metabolism and may be beneficial in developing a novel strategy for the prevention or treatment of hyperglycemia.
* cancer
* mouse models
* replication stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185120
}}
{{medline-entry
|title=Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253926


===MeSH Terms===
-


===Keywords===
|keywords=* EEG
G protein-coupled receptor (GPCR); TGR5; aging; bile acid; diabetes; energy metabolism; muscle hypertrophy; obesity; skeletal muscle metabolism
* EEG slowing
* brain aging
* dominant frequency
* prefrontal
|full-text-url=https://sci-hub.do/10.1177/1550059420914832
}}
{{medline-entry
|title=Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31635217


==Metabolic Syndrome and Cognitive Function in Midlife.==
|mesh-terms=* Humic Substances
===Abstract===
* Hydrogen Peroxide
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors associated with cognitive decline. We investigated the relationship between MetS and cognition in middle-aged adults. We hypothesized that higher numbers of MetS components will relate to poorer performance on executive function (EF) tasks as frontal lobe regions critical to EF are particularly vulnerable to cardiovascular disease. 197 adults (ages 40-60) participated. MetS was evaluated using established criteria. Composite scores for cognitive domains were computed as follows: Global cognitive function (subtests from the Wechsler Abbreviated Scale of Intelligence, 2nd Edition), EF (Stroop Color Word, Digit Span Backward, and Trails A and B), and memory (California Verbal Learning Test, 2 Edition). Higher number of MetS components was related to weaker EF-F(4, 191) = 3.94, p = .004, MetS components ß = -.14, p = .044. A similar relationship was detected for tests of memory-F(4, 192) = 7.86, p < .001, MetS components ß = -.15, p = .032. Diagnosis of MetS was not significantly associated with EF domain score (ß = -.05, p = .506) but was significantly associated with memory scores-F(4, 189) = 8.81, p < .001, MetS diagnosis ß = -.19, p = .006. Our findings support prior research linking MetS components at midlife to executive dysfunction and demonstrate that MetS, and its components are also associated with poorer memory function. This suggests that cognitive vulnerability can be detected at midlife. Interventions for MetS at midlife could alter cognitive outcomes.
* Hydrophobic and Hydrophilic Interactions
* Membranes, Artificial
* Polymers
* Sodium Hypochlorite
* Sulfones
* Ultrafiltration
|keywords=* chemical cleaning
* hydrogen peroxide (H2O2)
* membrane aging
* polyethersulfone (PES) ultrafiltration (UF) membrane
* sodium hypochlorite (NaClO)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843545
}}
{{medline-entry
|title=NF-κB signaling in skin aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634486


===MeSH Terms===
|mesh-terms=* Animals
-
* Cellular Senescence
* Humans
* NF-kappa B
* Phenotype
* Signal Transduction
* Skin Aging
* Skin Neoplasms
|keywords=* NF-κB
* Senescence-associated secretory phenotype
* Skin aging
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111160
}}
{{medline-entry
|title=Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634554


===Keywords===
|mesh-terms=* Administration, Cutaneous
Aging; Brain; Cognitive impairment; Executive function; Metabolic syndrome; Neuropsychological assessment
* Animals
* Emulsions
* Hydroxyproline
* Ionic Liquids
* Male
* Rats, Wistar
* Skin
* Skin Absorption
* Skin Aging
* Thioctic Acid
* Ultraviolet Rays
|keywords=* Anti – aging efficacy
* Ionic liquids
* Skin retention
* Solubility
* Α – lipoic acid
|full-text-url=https://sci-hub.do/10.1016/j.ejps.2019.105042
}}
{{medline-entry
|title=Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658636


==Interfering Peptides Targeting Protein-Protein Interactions in the Ethylene Plant Hormone Signaling Pathway as Tools to Delay Plant Senescence.==
===Abstract===
Interfering peptides (iPs) have been recognized as valuable substances to specifically target protein-protein interactions (PPIs) in senescence and disease. Although the concept of iPs has been validated for several PPIs in medical and pharmaceutical research, little attention so far has been paid to the enormous potential iPs that may provide to target and control plant growth and developmental processes or plant environmental responses. However, recent research on PPIs in the ethylene signaling pathway has identified the synthetic peptide NOP-1 derived from the nuclear localization signal of ethylene regulator EIN2 as an efficient inhibitor of typical ethylene responses such as ripening, aging, and senescence. Biophysical and biochemical studies on purified recombinant proteins of the ethylene receptor family from various plant species demonstrate that the synthetic peptide binds in the nM-μM range at the plant target. Here, we describe methods to evaluate and quantify the effect of the NOP-1 peptide on flower senescence as a typical ethylene response in the intact plant system. This approach will help to systematically advance our technological capability to delay plant ethylene responses and to expand shelf-life or vase life of fruits and flowers.


===MeSH Terms===
|keywords=* aging resistance
-
* graphene oxide
* nitrile-butadiene rubber
* nitrogen-doped
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835680
}}
==AVP==


===Keywords===
{{medline-entry
Ethylene signaling; Interfering peptides; Plant senescence; Protein–protein interactions
|title=Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606581


==Serum zinc concentrations and characteristics of zinc deficiency/marginal deficiency among Japanese subjects.==
|mesh-terms=* Adolescent
===Abstract===
* Adult
Studies that have examined serum zinc deficiency/marginal deficiency in developed countries, including Japan, are still limited. The aim of this study was to assess serum zinc concentrations and associated characteristics among Japanese subjects. This cross-sectional study, conducted from September 2016 to December 2018, included 2056 eligible subjects who participated in a voluntary health checkup. Serum zinc concentration categories were defined as deficiency (<60 μg/dL), marginal deficiency (≥60 to <80 μg/dL), and normal (≥80 μg/dL). Serum zinc concentrations were compared between the first age category (<40 years) and other age categories with Dunnett's method. Trends in P-values were estimated using the Jonckheere-Terpstra test for continuous variables. The proportions of subjects with deficiency and marginal deficiency were 0.4% and 46.0% in men, and 0.6% and 38.4% in women, respectively. The deficiency/marginal deficiency group had significantly lower lipid profiles and nutritional status, and a significantly lower proportion were non-daily drinkers in both genders. Older age was significantly associated with lower serum zinc concentration only in men. Our findings clarified a high proportion of serum zinc deficiency/marginal deficiency, especially in men, and suggest a possible association between serum zinc levels and nutritional status and alcohol consumption. It may be necessary to manage nutritional status, including zinc intake.
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Anxiety
* Avoidance Learning
* Cognition
* Cohort Studies
* Female
* Humans
* Male
* Middle Aged
* Object Attachment
* Oxytocin
* Sex Factors
* Vasopressins
* Young Adult
|keywords=* Age
* Attachment anxiety
* Oxytocin
* Processing speed
* Sex
* Vasopressin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943921
}}
==B4GALT1==


===MeSH Terms===
{{medline-entry
-
|title=Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171474


===Keywords===
aging; deficiency; epidemiology; nutrition; prevention; zinc


==Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding.==
|keywords=* Biomarker
===Abstract===
* Glycosylation
Ingesting protein-containing supplements and foods provides essential amino acids (EAA) necessary to increase muscle and whole-body protein synthesis (WBPS). Large variations exist in the EAA composition of supplements and foods, ranging from free-form amino acids to whole protein foods. We sought to investigate how changes in peripheral EAA after ingesting various protein and free amino acid formats altered muscle and whole-body protein synthesis. Data were compiled from four previous studies that used primed, constant infusions of L-(ring- H )-phenylalanine and L-(3,3- H )-tyrosine to determine fractional synthetic rate of muscle protein (FSR), WBPS, and circulating EAA concentrations. Stepwise regression indicated that max EAA concentration (EAAC ; R  = 0.524, [i]p[/i] < 0.001), EAAC  (R  = 0.341, [i]p[/i] < 0.001), and change in EAA concentration (ΔEAA; R = 0.345, [i]p[/i] < 0.001) were the strongest predictors for postprandial FSR, Δ (change from post absorptive to postprandial) FSR, and ΔWBPS, respectively. Within our dataset, the stepwise regression equation indicated that a 100% increase in peripheral EAA concentrations increases FSR by ~34%. Further, we observed significant ([i]p[/i] < 0.05) positive (R = 0.420-0.724) correlations between the plasma EAA area under the curve above baseline, EAAC , ΔEAA, and rate to EAAC  to postprandial FSR, ΔFSR, and ΔWBPS. Taken together our results indicate that across a large variety of EAA/protein-containing formats and food, large increases in peripheral EAA concentrations are required to drive a robust increase in muscle and whole-body protein synthesis.
* Lifespan regulation
* bre-4
* sqv-3
|full-text-url=https://sci-hub.do/10.1159/000510722
}}
==BACE1==


===MeSH Terms===
{{medline-entry
-
|title=Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32742258


===Keywords===
aging; amino acid kinetics; anabolism; essential amino acids; muscle protein synthesis; nutrition; protein; protein quality; whole body protein synthesis


==Internal Microscopic Diagnosis of Accelerated Aging of Proton Exchange Membrane Water Electrolysis Cell Stack.==
|keywords=* aging
===Abstract===
* behavior
The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or causing failure in the water electrolysis cell stack. In addition, there are five important physical parameters (current, voltage, flow, pressure and temperature) inside the water electrolysis cell stack, which can change the performance and shorten the life of the cell stack. However, the present techniques obtain data only by external simulation or single measurement; they cannot collect the internal real data in operation instantly and accurately. This study discusses the causes for aging or failure, and develops an internal real-time microscopic diagnosis tool for accelerated aging of the PEM water electrolysis cell stack. A flexible integrated (current, voltage, flow, pressure and temperature) microsensor applicable to the inside (high voltage and electrochemical environment) of the PEM water electrolysis cell stack is developed by using micro-electro-mechanical systems (MEMS) technology; it is embedded in the PEM water electrolysis cell stack for microscopic diagnosis of accelerated aging, and 100-h durability and reliability tests are performed. The distribution of important physical parameters inside the PEM water electrolysis cell stack can be measured instantly and accurately, so as to adjust it to the optimal operating conditions, and the local aging and failure problems are discussed.
* electrical stimulation
* neurogenesis
* rats
* stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365235
}}
{{medline-entry
|title=Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058320


===MeSH Terms===
-


===Keywords===
|keywords=* Aging mice
PEM water electrolysis cell stack; accelerated aging; flexible integrated microsensor; microscopic diagnosis
* Brain-derived neurotrophic factor precursor
* Latent expression pattern
* Lead
* Pubertal exposure
* Synaptic deficits
* Tau phosphorylation
|full-text-url=https://sci-hub.do/10.1016/j.etap.2020.103350
}}
==BAD==


==Influence of aging on deterioration of patients with COVID-19.==
{{medline-entry
===Abstract===
|title=I  imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway.
Aging is an important factor affecting the deterioration of patients with coronavirus disease 2019 (COVID-19). The aging and degeneration of various tissues and organs in the elderly lead to impaired organ function. Underlying conditions such as chronic lung disease, cardiovascular disease, and diabetes in aged patients are associated with higher mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily interacts with the cell surface receptor angiotensin-converting enzyme (ACE) 2 and other accessory proteins such as 78 kDa glucose-regulated protein 78 (GRP78) and CD147. Thus, altered receptor signals in aging and chronic disease play a role in SARS-CoV-2 infection, and are associated with a higher risk of deterioration in different organs. In this review, after a brief introduction to the link between aging and receptors for SARS-CoV-2, we focus on the risk of deterioration in different organs of COVID-19 patients considering aging as the main factor. We further discuss the structural and/or physiological changes in the immune system and organs (lung, heart, kidney, vessels, nerve system), as well as those associated with diabetes, in aging patients, and speculate on the most likely mechanisms underlying the deterioration of COVID-19 patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33128688


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
ACE2; CD147; COVID-19; GRP78; aging
* Alzheimer’s disease
* Behavior
* I2 imidazoline receptors
* NFAT
* Neuroinflammation
* Neuroprotection
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00281-2
}}
==BAK1==


==Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.==
{{medline-entry
===Abstract===
|title=Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.
Cortical injury, such as stroke, causes neurotoxic cascades that lead to rapid death and/or damage to neurons and glia. Axonal and myelin damage in particular, are critical factors that lead to neuronal dysfunction and impair recovery of function after injury and can be exacerbated in the aged brain where white matter damage is prevalent. Therapies that can ameliorate myelin damage and promote repair by targeting oligodendroglia, the cells that produce and maintain myelin, may facilitate recovery after injury, especially in the aged brain where these processes are already compromised. We previously reported that a novel therapeutic, Mesenchymal Stem Cell derived extracellular vesicles (MSC-EVs), administered intravenously at both 24 h and 14 days after cortical injury reduced microgliosis (Go et al. 2019), reduced neuronal pathology (Medalla et al. 2020), and improved motor recovery (Moore et al. 2019) in aged female rhesus monkeys. Here, we evaluated the effect of treatment with MSC-EVs on changes in oligodendrocyte maturation and associated myelin markers in the sublesional white matter using immunohistochemistry, confocal microscopy, stereology, qRT-PCR, and ELISA. Compared to vehicle-treated control, EV-treated monkeys showed a reduction in the density of damaged oligodendrocytes. Further, EV-treatment was associated with enhanced myelin maintenance, evidenced by upregulation of myelin-related genes and increases in actively-myelinating oligodendrocytes in in sublesional white matter. These changes in myelination correlate with the rate of motor recovery, suggesting that improved myelin maintenance facilitates this recovery. Overall, our results suggest that EVs act on oligodendrocytes to support myelination and likely improve functional recovery after injury in the aged brain. SIGNIFICANCE: We previously reported that after cortical injury in the aged monkey brain, EVs reduce neuronal pathology (Medalla et al. 2020), microgliosis (Go et al. 2019), and facilitate recovery of function. However, the effect of injury on oligodendrocytes and myelination has not been characterized in the primate brain (Dewar et al. 1999; Sozmen et al. 2012; Zhang et al. 2013). In the present study, we assessed changes in myelination after cortical injury in these same aged monkeys. Our results show, for the first time, that MSC-EVs support recovery of function after cortical injury by enhancing myelin maintenance in the aged primate brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32710818


===MeSH Terms===
|mesh-terms=* Animals
-
* Apoptosis
* Brain
* Cell Line, Tumor
* Cells, Cultured
* Female
* Heterogeneous-Nuclear Ribonucleoproteins
* Male
* Mice
* Mice, Inbred C57BL
* Mutation
* Neural Stem Cells
* Neurogenesis
* Nonsense Mediated mRNA Decay
* Polypyrimidine Tract-Binding Protein
* RNA Splicing
* bcl-2 Homologous Antagonist-Killer Protein
|keywords=* AS-NMD
* BAK
* BCL2 family proteins
* NMD
* PTB
* PTBP
* PTBP2
* UPF2
* alternative splicing
* cell death
* neural development
* neurogenesis
* neuronal lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529960
}}
==BANF1==


===Keywords===
{{medline-entry
Aging; Cortical injury; Extracellular vesicles; Monkeys; Myelin; Non-human primates; Oligodendrocytes; Stroke; White matter
|title=An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32783369


==Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.==
===Abstract===
The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the course and severity of infection. We review the current literature pertaining to the mechanisms of cutaneous viral invasion for classical skin-tropic, oncogenic, and vector-borne skin viruses. We discuss the skin's evolved mechanisms for innate immune viral defense against these invading pathogens, as well as unique strategies utilized by the viruses to escape immune detection. We additionally explore the roles that demographic and environmental factors, such as age, biological sex, and the cutaneous microbiome, play in altering the host immune response to viral threats.


===MeSH Terms===
|keywords=* BANF1
-
* Néstor-Guillermo progeria syndrome
* premature aging
* progeria
* whole exome sequencing
|full-text-url=https://sci-hub.do/10.1002/ajmg.a.61777
}}
==BATF==


===Keywords===
{{medline-entry
antiviral proteins; cutaneous innate immunity; cutaneous microbiome; skin aging; skin antiviral response; skin viruses
|title=LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483833


==Sequenced application of glutathione as an antioxidant with an organic biostimulant improves physiological and metabolic adaptation to salinity in wheat.==
===Abstract===
Globally, salinity threatens the agricultural crops productivity by inhibiting plant growth and development through osmotic stress and ionic cytotoxicity. The polygenic nature of salinity offers several pragmatic shotgun approaches to improve salinity tolerance. The present study investigated the potential of glutathione (GSH; 1 mM) as an antioxidant and moringa leaf extract (MLE; 3%) as an organic biostimulant applied in sequence as seed priming and foliar spray on wheat growth, physiology and metabolic adaptation under saline conditions (9.16 dS m ). Plants without any treatment and water spray (H O) were considered controls. Salinity induced osmotic stress reduced the plant tissue water status and photosynthetic performance, and perturbed ionic (K /Na , Ca /Na , K +Ca /Na ) and hormonal (IAA, GA , zeatin, ABA) homeostasis, consequently affected growth and yield in wheat. Sequenced applied MLE and/or GSH improved osmotic stress tolerance by stabilizing membrane integrity and decreasing electrolyte leakage. These positive results were owed to enhanced endogenous GSH and ascorbate levels. Improved tissue water status was attributed to increased osmotic adjustment, better ionic and hormonal homeostasis contributed to improving photosynthetic efficiency and growth under salinity. Exogenously applied MLE and GSH sequences improved grain yield, which was attributed to the maintenance of green leaf area and delayed senescence associated with an increase in photosynthetic pigments and chlorophyll fluorescence traits. In crux, exogenous applied MLE and/or GSH can be the best physiological strategy to reduce the deleterious effects of salinity and improve physiological and metabolic adaptation in wheat under saline field conditions.


===MeSH Terms===
|keywords=* Bhlhe40
-
* VSMC calcification/senescence
* diabetes
* lncRNA-ES3
* microRNA
* vascular aging
|full-text-url=https://sci-hub.do/10.1111/nyas.14381
}}
==BAX==


===Keywords===
{{medline-entry
Antioxidants; Delayed senescence; Ionic homeostasis; Osmotic stress; Photosynthetic efficiency
|title=Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X  -[[BAX]] interaction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652830


==Carnitine promotes recovery from oxidative stress and extends lifespan in [i]C. elegans[/i].==
===Abstract===
Carnitine is required for transporting fatty acids into the mitochondria for β-oxidation. Carnitine has been used as an energy supplement but the roles in improving health and delaying aging remain unclear. Here we show in [i]C. elegans[/i] that L-carnitine improves recovery from oxidative stress and extends lifespan. L-carnitine promotes recovery from oxidative stress induced by paraquat or juglone and improves mobility and survival in response to H O  and human amyloid (Aβ) toxicity. L-carnitine also alleviates the oxidative stress during aging, resulting in moderate but significant lifespan extension, which was dependent on SKN-1 and DAF-16. Long-lived worms with germline loss ([i]glp-1[/i]) or reduced insulin receptor activity ([i]daf-2)[/i] recover from aging-associated oxidative stress faster than wild-type controls and their long lifespans were not further increased by L-carnitine. A new gene, T08B1.1, aligned to a known carnitine transporter OCTN1 in humans, is required for L-carnitine uptake in [i]C. elegans[/i]. T08B1.1 expression is elevated in [i]daf-2[/i] and [i]glp-1[/i] mutants and its knockdown prevents L-carnitine from improving oxidative stress recovery and prolonging lifespan. Together, our study suggests an important role of L-carnitine in oxidative stress recovery that might be important for healthy aging in humans.


===MeSH Terms===
|keywords=* ABT-263
-
* BCL-XL
* chemotherapy
* radiation
* senescence
* senolytic
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530780
}}
{{medline-entry
|title=CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31657930


===Keywords===
aging; amyloid; carnitine; oxidative stress; transporter


==Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.==
|keywords=* CREB signaling
===Abstract===
* aging
Matcha Green Tea Powder contains a variety of active ingredients beneficial to health, such as tea catechins, lutein and vitamin K. It is also known that these ingredients confer benefits upon cognitive functions of elderly people. Therefore, we aimed to investigate the relationship between a daily supplementation of Matcha and the change in cognitive functions of community-dwelling elderly people. A randomized, double-blind, placebo-controlled 12-week trial was performed. Sixty-one participants were recruited and randomly assigned to receive test drink containing 3g powder from fresh Matcha or placebo powder per day. Changes in cognitive function were assessed utilizing a psychometric test battery. Daily food intake was assessed by a Brief-type Self-administered Diet History Questionnaire (BDHQ). In the gender-specific analysis, a significant cognitive enhancement was observed in the Montreal Cognitive Assessment (MoCA) score in the active group of women. In dietary analysis, we found a significant inverse correlation between consumption of vitamin K in daily diet, excluding test drinks, and change in MoCA. The present study suggests that daily supplementation of Matcha Green Tea Powder has protective effects against cognitive decline in community-dwelling elderly women.
* brain
* hippocampus
* ionizing radiation
* label-free proteomics
|full-text-url=https://sci-hub.do/10.1021/acs.jproteome.9b00552
}}
==BAZ2B==


===MeSH Terms===
{{medline-entry
-
|title=Two conserved epigenetic regulators prevent healthy ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103178


===Keywords===
|mesh-terms=* Aging
aging; cognitive function; green tea; impulsivity; memory function; vitamin K
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Cognition
* Cognitive Dysfunction
* Epigenesis, Genetic
* Healthy Aging
* Histone-Lysine N-Methyltransferase
* Histones
* Humans
* Longevity
* Lysine
* Male
* Memory
* Methylation
* Mice
* Mitochondria
* Neurons
* Proteins
* RNA Interference
* Spatial Learning
* Transcription Factors, General


==Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.==
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2037-y
===Abstract===
}}
5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis in vertebrate species; a reaction catalyzed by the mitochondrial ALA synthase 1 (ALAS1) enzyme. Previously we reported that knockdown of the ubiquitously expressed ALAS1 gene in mice disrupts normal glucose metabolism, attenuates mitochondrial function and results in a prediabetic like phenotype when animals pass 20-weeks of age (Saitoh et al., 2018). Contrary to our expectations, the cytosolic and mitochondrial heme content of ALAS1 heterozygous (A1+/-) mice were similar to WT animals. Therefore, we speculated that regulatory "free heme" may be reduced in an age dependent manner in A1 ± mice, but not total heme. Here, we examine free and total heme from the skeletal muscle and liver of WT and A1 ± mice using a modified acetone extraction method and examine the effects of aging on free heme by comparing the amounts at 8-12 weeks and 30-36 weeks of age, in addition to the mRNA abundance of ALAS1. We found an age-dependent reduction in free heme in the skeletal muscle and liver of A1 ± mice, while WT mice showed only a slight decrease in the liver. Total heme levels showed no significant difference between young and aged WT and A1 ± mice. ALAS1 mRNA levels showed an age-dependent reduction similar to that of free heme levels, indicating that ALAS1 mRNA expression levels are a major determinant for free heme levels. The free heme pools in skeletal muscle tissue were almost 2-fold larger than that of liver tissue, suggesting that the heme pool varies across different tissue types. The expression of heme oxygenase 1 (HO-1) mRNA, which is expressed proportionally to the amount of free heme, were similar to those of free heme levels. Taken together, this study demonstrates that the free heme pool differs across tissues, and that an age-dependent reduction in free heme levels is accelerated in mice heterozygous for ALAS1, which could account for the prediabetic phenotype and mitochondrial abnormality observed in these animals.
==BCL6==


===MeSH Terms===
{{medline-entry
-
|title=Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452837


===Keywords===
5-Aminolevulinate synthase 1 (ALAS1); 5-Aminolevulinic acid (ALA); Aging; Free heme; Liver; Skeletal muscle


==Effects of exercise-heat stress on circulating stress hormones and interleukin-6 in young and older men.==
|keywords=* Adaptive immunity
===Abstract===
* Aging
Aging is associated with impairments in thermoregulatory function, which may augment the neuroendocrine and immune response in older relative to young adults during physical activity in the heat. This study was therefore aimed at examining changes in circulating endocrine hormones as cortisol (COR), prolactin (PRL), human growth hormone (hGH) and interleukin-6 (IL-6) in young and older men prior to and following an incremental, exercise-heat stress protocol (40°C and ~15% relative humidity). Accordingly, ten habitually active young (mean±SD; 21 ± 1 years) and ten older (65 ± 3 years) men performed three 30-min bouts of cycling at increasing metabolic heat productions (300, 400 and 500 W, equal to light, moderate and vigorous exercise), each separated by a 15-min recovery. Consistent with our hypothesis, we observed augmented IL-6 in older (3.55 ± 1.62 pg/mL) compared to young men (1.59 ± 0.88 pg/mL) following the protocol (p < 0.001). However, no significant between-group differences were observed for COR and hGH (all p > 0.050). We show that when assessed following incremental exercise in the heat, older men display augmented interleukin-6, but similar levels of stress hormones relative to young men.
* Cellular senescence
* T cells
* Vaccines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324201
}}
==BCR==


===MeSH Terms===
{{medline-entry
-
|title=The presence of CLL-associated stereotypic B cell receptors in the normal [[BCR]] repertoire from healthy individuals increases with age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31485252


===Keywords===
Heat stress; aging; core temperature; immune; stress; stress hormones


==Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium.==
|keywords=* Aging
===Abstract===
* B-lymphocyte
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18-92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. "PSQI # 1 Subjective sleep quality" and "PSQI #5 Sleep disturbances" were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with "PSQI #5 Sleep disturbances" emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.
* BCR repertoire
* CLL
* Stereotypic BCR
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714092
}}
==BDNF==


===MeSH Terms===
{{medline-entry
-
|title=Influence of [i][[BDNF]][/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269104


===Keywords===
aging; atrophy; cortex; sleep


==GATA6 regulates aging of human mesenchymal stem/stromal cells.==
|keywords=* Aging
===Abstract===
* BDNF gene
Cellular reprogramming forcing the expression of pluripotency markers can reverse aging of cells but how molecular mechanisms through which reprogrammed cells alter aging-related cellular activities still remain largely unclear. In this study, we reprogrammed human synovial fluid-derived mesenchymal stem cells (MSCs) into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation. Using the parental and reprogrammed MSCs as control nonrejuvenated and rejuvenated cells, respectively, for comparative analysis, we found that aging-related activities were greatly reduced in reprogrammed MSCs compared with those in their parental lines, indicating reversal of cell aging. Global transcriptome analysis revealed differences in activities of regulatory networks associated with inflammation and proliferation. Mechanistically, we demonstrated that, compared with control cells, the expression of GATA binding protein 6 (GATA6) in reprogrammed cells was attenuated, resulting in an increase in the activity of sonic hedgehog signaling and the expression level of downstream forkhead box P1 (FOXP1), in turn ameliorating cellular hallmarks of aging. Lower levels of GATA6 expression were also found in cells harvested from younger mice or lower passage cultures. Our findings suggest that GATA6 is a critical regulator increased in aged MSCs that controls the downstream sonic hedgehog signaling and FOXP1 pathway to modulate cellular senescence and aging-related activities.
* aging-related diseases
* polymorphism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673859
}}
{{medline-entry
|title=Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and [[BDNF]]: Insights from Subgroup Analysis and Meta-Regression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961777


===MeSH Terms===
-


===Keywords===
|keywords=* aging
aging; cell signaling; mesenchymal stem cells; reprogramming; transcription factors
* antioxidant
* brain functions
* brain plasticity
* cognition
* psychomotor functions
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551086
}}
{{medline-entry
|title=Astroglia-Derived [[BDNF]] and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708382


==The Aging Stress Response and Its Implication for AMD Pathogenesis.==
===Abstract===
Aging induces several stress response pathways to counterbalance detrimental changes associated with this process. These pathways include nutrient signaling, proteostasis, mitochondrial quality control and DNA damage response. At the cellular level, these pathways are controlled by evolutionarily conserved signaling molecules, such as 5'AMP-activated protein kinase (AMPK), mechanistic target of rapamycin (mTOR), insulin/insulin-like growth factor 1 (IGF-1) and sirtuins, including SIRT1. Peroxisome proliferation-activated receptor coactivator 1 alpha (PGC-1α), encoded by the [i]PPARGC1A[/i] gene, playing an important role in antioxidant defense and mitochondrial biogenesis, may interact with these molecules influencing lifespan and general fitness. Perturbation in the aging stress response may lead to aging-related disorders, including age-related macular degeneration (AMD), the main reason for vision loss in the elderly. This is supported by studies showing an important role of disturbances in mitochondrial metabolism, DDR and autophagy in AMD pathogenesis. In addition, disturbed expression of PGC-1α was shown to associate with AMD. Therefore, the aging stress response may be critical for AMD pathogenesis, and further studies are needed to precisely determine mechanisms underlying its role in AMD. These studies can include research on retinal cells produced from pluripotent stem cells obtained from AMD donors with the mutations, either native or engineered, in the critical genes for the aging stress response, including [i]AMPK[/i], [i]IGF1[/i], [i]MTOR[/i], [i]SIRT1[/i] and [i]PPARGC1A[/i].


===MeSH Terms===
|keywords=* AMPA receptors
-
* Arc/Arg3.1
* GABA receptors
* TrkB receptors
* aging
* calcium signalling
* dendritic spines
* diet
* enriched environment
* glia-neuron interactions
* ion conductance microscopy
* synaptic scaling
* synaptic strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407492
}}
{{medline-entry
|title=[[BDNF]] reverses aging-related microglial activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32664974


===Keywords===
AMD; DNA damage response; PGC-1α; SIRT1; age-related macular degeneration; aging; autophagy; insulin/IGF-1; mitochondrial quality control; the aging stress response


==The Impact of Age on the Association Between Physical Activity and White Matter Integrity in Cognitively Healthy Older Adults.==
|keywords=* Aging
===Abstract===
* BDNF
Cognition emerges from coordinated processing among distributed cortical brain regions, enabled through interconnected white matter networks. Cortical disconnection caused by age-related decline in white matter integrity (WMI) is likely to contribute to age-related cognitive decline. Physical activity (PA) has been suggested to have beneficial effects on white matter structure. However, its potential to counteract age-related decline in WMI is not yet well established. The present explorative study analyzed if PA was associated with WMI in cognitively healthy older adults and if this association was modulated by age. Forty-four cognitively healthy older individuals (aged 60-88 years) with diffusion-tensor imaging (DTI) and PA measurements were included from the AgeGain study. Voxelwise analysis using Tract-Based Spatial Statistics (TBSS) demonstrated that PA was associated with WMI in older adults. However, results emphasized that this association was restricted to high age. The association between PA and WMI was found in widespread white matter regions suggesting a global rather than a regional effect. Supplementary analyses demonstrated an association between the integrity of these regions and the performance in memory [verbal learning and memory test (VLMT)] and executive functioning (Tower of London).Results of the present explorative study support the assumption that PA is associated with WMI in older adults. However, results emphasize that this association is restricted to high age. Since cognitive decline in the elderly is typically most pronounced in later stages of aging, PA qualifies as a promising tool to foster resilience against age-related cognitive decline, [i]via[/i] the preservation of the integrity of the brains WM.
* CREB
* Microglial activation
* NF-кB
* TrkB
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362451
}}
{{medline-entry
|title=High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32509119


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
actigraphy; cognition; healthy aging; physical activity; white matter integrity
* exercise
* functional capacity
* muscle strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241618
}}
{{medline-entry
|title=Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32497590


==Childhood adversity and trajectories of multimorbidity in mid-late life: China health and longitudinal retirement study.==
===Abstract===
The association between childhood adversity and an individual's health in later life has been extensively studied in Western societies; however, little is known about this association for the development of multimorbidity in China. Three waves (2011-2012, 2013 and 2015) of the China Health and Retirement Longitudinal Study were used for adults aged 45-101 years. Multimorbidity was assessed by the summed scores of self-reported physician diagnoses of 14 chronic diseases. Childhood adversity was measured by the incidence of childhood abuse and neglect, negative caregiver's characteristics and low socioeconomic status. Latent growth curve modelling was used to investigate the trajectory of multimorbidity by childhood adversity. Parental physical abuse was associated with increased number of chronic diseases (intercept: 0.119; 95% CI: 0.033 to 0.205 for men and 0.268: 95% CI: 0.188 to 0.348 for women) and a higher rate of increase (slope: 0.013: 95% CI: 0.000 to 0.027 for men and 0.022: 95% CI: 0.008 to 0.036 for women) in multimorbidity. Adequacy of food was associated with a lower number chronic diseases at baseline (men: -0.171: 95% CI: -0.245 to -0.097; women: -0.223: 95% CI: -0.294 to -0.152) and a slower rate of change in multimorbidity (men: -0.015 per year: 95% CI: -0.027 to -0.003; women: -0.012 per year: 95% CI: -0.024 to -0.001). The results demonstrate that childhood adversity exerts long-lasting effects on multimorbidity among older adults in China. Prevention of childhood maltreatment may delay or even avert the emergence of multimorbidity in later life.


===MeSH Terms===
|keywords=* Aging
-
* Dorsal striatum
* Metformin
* Parkinson's disease
* Reactive astrocyte
|full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2020.108173
}}
{{medline-entry
|title=Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32489703


===Keywords===
gerontology; life course epidemiology; lifecourse / childhood circumstances; morbidity; social and life-course epidemiology


==Acute effects of inspiratory loading in older women: Where the breath meets the heart.==
|keywords=* BDNF
===Abstract===
* adipocyte progenitors
We tested the hypothesis that inspiratory resistive loading (IRL) increases vagal-mediated complexity of heart rate variability (HRV) in older women. We recorded heart rate continually during 30 breaths with Sham or IRL (30 % of maximal inspiratory pressure) in sitting position. The normalized spectral power in the low (LFn) and high (HFn) frequency bands and the symbolic dynamics measures for 0 V, 2UV and 2 L V were obtained. HFn was higher and LFn was lower during IRL than Sham (p < 0.05). During IRL, 2UV component increased more than Sham (p < 0.05) while 0 V index remained unchanged (p> 0.05). In conclusion, acute IRL improved vagal modulation index of both linear (spectral analysis) and non-linear analysis (symbolic dynamics) in older women.
* adipose tissue
* aging
* sympathetic innervation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220283
}}
{{medline-entry
|title=The Role of [[BDNF]] on Aging-Modulation Markers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32397504


===MeSH Terms===
-


===Keywords===
|keywords=* BBB
Aging; Heart rate variability; Maximal inspiratory pressure; Respiratory muscles
* astrocytes
* brain aging
* in vivo model
* low dose BDNF
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287884
}}
{{medline-entry
|title=Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268299


==[Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.]==
===Abstract===
The aim of this work was to examine the content of aryl hydrocarbon receptor interacting protein (AIP) in fibroblasts of human dermis from 20 weeks of pregnancy until 85 years old, and defining of a role of AIP in age-dependent changes in the number of fibroblasts in the dermis. AIP, proliferating cells nuclear antigen (PCNA) were detected with indirect immunohistochemical technique. Results showed that a portion of fibroblasts with positive staining for AIP in the dermis is gradually increased from 20 weeks of pregnancy until 85 years old. A total number and percent of PCNA positive fibroblasts in dermis decreased with progression of age. Most sufficient age-dependent reduction in a total and PCNA positive number of dermal fibroblast was observed from antenatal until 40 years of life. Correlation analysis showed that both age-dependent decrease in the number of fibroblasts and retardation of their proliferation are significantly associated with age-related increase in the number of AIP positive fibroblasts in dermis. Results allow to suggest that AIP is involved in age-dependent decrease in the number and proliferation of fibroblasts in human dermis.


===MeSH Terms===
|keywords=* aging
-
* autophagy
* mitochondrial dysfunction
* polyamine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185103
}}
{{medline-entry
|title=Microglia senescence occurs in both substantia nigra and ventral tegmental area.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32275335


===Keywords===
AIP; PCNA; aging; fibroblasts; skin


==Evaluation of latent fingermark color contrast as aging parameter under different environmental conditions: A preliminary study.==
|keywords=* Parkinson's disease
===Abstract===
* aging-dependent neurodegeneration
This research expands previous studies in which color contrast between ridges and furrows of powder-enhanced latent fingermarks was explored as a possible aging parameter. The main goal is to test the sensitivity of the technique across a predetermined set of factors. In this case, experiment factors have included two donors who deposited sebaceous- and eccrine-rich fingermarks onto ceramic tile and polystyrene plastic. These were developed with either black carbon or titanium dioxide powder (TiO  ) over eight time periods (0-72 days) and aged under three light conditions (direct light, shade, and darkness). The mean intensity (MI) and intensity amplitude (IA) metrics of color were collected from each image for statistical analyses. Results show that color contrast is affected significantly by substrate, secretion, and powder types, with an interaction effect between the substrate and powder type on both MI and IA metrics. The degree of light exposure did not have a noticeable impact on distinguishing aging patterns of fingermarks by neither powder methods. Different aging patterns were detected between sebaceous-rich and their eccrine-rich counterparts for all light conditions using regression analysis. All eccrine-rich fingermarks exhibited little (or minimal) change in IA over time, whereas sebaceous-rich samples showed varied patterns, from significant decreases to slight increases. These findings confirm and expand previous observations on the potential use of MI and IA as metrics to study latent fingermark degradation patterns that could eventually be used to estimate the age of a fingermark.
* dopamine neurons
* microglia complexity
* stereological analyses
* tyrosine hydroxylase; microglia senescence
|full-text-url=https://sci-hub.do/10.1002/glia.23834
}}
{{medline-entry
|title=Towards an understanding of the physical activity-[[BDNF]]-cognition triumvirate: A review of associations and dosage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171785


===MeSH Terms===
|mesh-terms=* Aging
-
* Brain-Derived Neurotrophic Factor
* Cognition
* Exercise
* Healthy Aging
* Humans
|keywords=* Ageing
* BDNF
* Brain
* Physical activity
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101044
}}
{{medline-entry
|title=Impact of [[BDNF]] and sex on maintaining intact memory function in early midlife.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948671


===Keywords===
|mesh-terms=* Brain
aging; carbon black; color contrast; degradation; environment; fingerprint; latent fingermark; powder; titanium dioxide
* Brain-Derived Neurotrophic Factor
* Cognition
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Memory
* Memory, Short-Term
* Menopause
* Middle Aged
* Neuroprotective Agents
* Neuropsychological Tests
* Reproduction
* Sex Characteristics
|keywords=* Aging
* BDNF
* Hormones
* Memory
* Menopause
* Sex differences
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.014
}}
{{medline-entry
|title=Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901624


==Altered heart rate variability during sleep in mild cognitive impairment.==
===Abstract===
Cardiovascular autonomic dysfunction, as measured by short-term diurnal heart rate variability (HRV), has been reported in older adults with mild cognitive impairment (MCI). However, it is unclear whether this impairment also exists during sleep in this group. We, therefore, compared overnight HRV during sleep in older adults with MCI and those with subjective cognitive impairment (SCI). Older adults (n = 210) underwent overnight polysomnography. Eligible participants were characterized as multi-domain MCI or SCI. The multi-domain MCI group was comprised of amnestic and non-amnestic subtypes. Power spectral analysis of HRV was conducted on the overnight electrocardiogram during non-rapid eye movement (NREM), rapid eye movement (REM), N1, N2, N3 sleep stages, and wake periods. High-frequency HRV (HF-HRV) was employed as the primary measure to estimate parasympathetic function. The MCI group showed reduced HF-HRV during NREM sleep (p = 0.018), but not during wake or REM sleep (p > 0.05) compared to the SCI group. Participants with aMCI compared to SCI had the most pronounced reduction in HF-HRV across all NREM sleep stages-N1, N2, and N3, but not during wake or REM sleep. The naMCI sub-group did not show any significant differences in HF-HRV during any sleep stage compared to SCI. Our study showed that amnestic MCI participants had greater reductions in HF-HRV during NREM sleep, relative to those with SCI, suggesting potential vulnerability to sleep-related parasympathetic dysfunction. HF-HRV, especially during NREM sleep, may be an early biomarker for dementia detection.


===MeSH Terms===
|keywords=* Aging
-
* BDNF
* Object location memory
* Radial arm maze
* Spatial memory
* Testosterone
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080566
}}
{{medline-entry
|title=The effects of aerobic exercise intensity on memory in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665610


===Keywords===
aging; dementia; heart rate variability; mild cognitive impairment; sleep


==Melatonin delays leaf senescence of postharvest Chinese flowering cabbage through ROS homeostasis.==
|keywords=* BDNF
===Abstract===
* activité physique
Reactive oxygen species (ROS) trigger and accelerate leaf senescence. Melatonin, a low molecular compound with several biological functions in plants, is known to delay leaf senescence in different species, including Chinese flowering cabbage. However, the mechanism(s) underpinning melatonin-delayed leaf senescence remains unclear. Here, we found that melatonin lowered the expression of chlorophyll catabolic genes (BrPAO and BrSGR1) and senescence-associated genes (BrSAG12 and BrSEN4), decreased chlorophyll loss, minimized the alteration in Fv/Fm ratio and remarkably delayed senescence of Chinese flowering cabbage after harvest. Moreover, the over-accumulation of O , hydrogen peroxide (H O ) and malondialdehyde contents and the expression of respiratory burst oxidase homologues (RBOH) genes (BrRbohB, BrRbohC, BrRbohD, BrRbohD2 and BrRbohE) were significantly inhibited by melatonin treatment. Melatonin-treated cabbages also showed higher O , OH  and DPPH radical scavenging capacity and enhanced activities of peroxidase (POD), superoxide dismutase (SOD) and their gene expressions. Up-regulation of key components of ascorbate-glutathione (AsA-GSH) cycle, the metabolic pathway that detoxify H O , was also observed in melatonin-treated cabbages. These findings suggest that melatonin-delayed postharvest leaf senescence of postharvest Chinese flowering cabbage may be mediated, at least in part, by maintaining ROS homeostasis through restraining RBOHs-catalyzed ROS production and enhancing the activity of ROS-scavenging system including major antioxidant enzymes and AsA-GSH cycle.
* aging
* cognition
* entraînement par intervalles de haute intensité
* executive functions
* exercice
* exercise
* fonctions exécutives
* high-intensity interval training
* memory
* mémoire
* physical activity
* vieillissement
|full-text-url=https://sci-hub.do/10.1139/apnm-2019-0495
}}
{{medline-entry
|title=Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor ([[BDNF]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524100


===MeSH Terms===
-


===Keywords===
|keywords=* BDNF
Chinese flowering cabbage; Leaf senescence; Melatonin; ROS homeostasis
* Brain aging
* neurophysiologic alterations
* neuroprotection
* vitamin D supplementation
|full-text-url=https://sci-hub.do/10.1080/1028415X.2019.1665854
}}
{{medline-entry
|title=Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum [[BDNF]] Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31498125


==Smart Nanofibers with Natural Extracts Prevent Senescence Patterning in a Dynamic Cell Culture Model of Human Skin.==
|mesh-terms=* Aged
===Abstract===
* Brain-Derived Neurotrophic Factor
Natural cosmetic products have recently re-emerged as a novel tool able to counteract skin aging and skin related damages. In addition, recently achieved progress in nanomedicine opens a novel approach yielding from combination of modern nanotechnology with traditional treatment for innovative pharmacotherapeutics. In the present study, we investigated the antiaging effect of a pretreatment with [i]Myrtus communis[/i] natural extract combined with a polycaprolactone nanofibrous scaffold (NanoPCL-M) on skin cell populations exposed to UV. We set up a novel model of skin on a bioreactor mimicking a crosstalk between keratinocytes, stem cells and fibroblasts, as in skin. Beta-galactosidase assay, indicating the amount of senescent cells, and viability assay, revealed that fibroblasts and stem cells pretreated with NanoPCL-M and then exposed to UV are superimposable to control cells, untreated and unexposed to UV damage. On the other hand, cells only exposed to UV stress, without NanoPCL-M pretreatment, exhibited a significantly higher yield of senescent elements. Keratinocyte-based 3D structures appeared disjointed after UV-stress, as compared to NanoPCL-M pretreated samples. Gene expression analysis performed on different senescence associated genes, revealed the activation of a molecular program of rejuvenation in stem cells pretreated with NanoPCL-M and then exposed to UV. Altogether, our results highlight a future translational application of NanoPCL-M to prevent skin aging.
* Cognition
* Correlation of Data
* Exercise
* Female
* Healthy Aging
* Healthy Lifestyle
* Humans
* Learning
* Male
* Mindfulness
* Neuropsychological Tests
* Outcome Assessment, Health Care
|keywords=* Aging
* brain-derived neurotrophic factor
* cognitive training
* mindfulness
* physical exercise
|full-text-url=https://sci-hub.do/10.3233/JAD-190756
}}
{{medline-entry
|title=Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398773


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Antidepressive Agents
* Autoimmunity
* Biomarkers
* Brain
* Brain-Derived Neurotrophic Factor
* Depression
* Dietary Supplements
* Docosahexaenoic Acids
* Fatty Acid Elongases
* Fatty Acids
* Fish Oils
* Inflammation
* Linoleic Acids, Conjugated
* Liver
* Male
* Mice, Inbred MRL lpr
* NF-E2-Related Factor 2
* Oxidative Stress
* Stearoyl-CoA Desaturase
* Tumor Necrosis Factor-alpha
|keywords=* brain derived neurotrophic factor
* brain fatty acid profile
* conjugated linoleic acid
* depression
* fish oil
* nuclear erythroid related factor-2
|full-text-url=https://sci-hub.do/10.1002/mnfr.201900243
}}
==BGN==


===Keywords===
{{medline-entry
4D dynamic model; biophysics; cell senescence; cellular mechanisms; nanofibers; natural extracts; precision medicine; skin aging; stem cells
|title=Alterations of local functional connectivity in lifespan: A resting-state fMRI study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32462815


==Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?==
===Abstract===
The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay detects DNA breakage by labeling the free 3'-hydroxyl termini. Given that genomic DNA breaks arise during early and late stages of apoptosis, TUNEL staining continues to be widely used as a measure of apoptotic cell death. The advantages of the assay include its relative ease of performance and the broad availability of TUNEL assay kits for various applications, such as single-cell analysis of apoptosis in cell cultures and tissue samples. However, as briefly discussed herein, aside from some concerns relating to the specificity of the TUNEL assay itself, it was demonstrated some twenty years ago that the early stages of apoptosis, detected by TUNEL, can be reversed. More recently, compelling evidence from different biological systems has revealed that cells can recover from even late stage apoptosis through a process called anastasis. Specifically, such recovery has been observed in cells exhibiting caspase activation, genomic DNA breakage, phosphatidylserine externalization, and formation of apoptotic bodies. Furthermore, there is solid evidence demonstrating that apoptotic cells can promote neighboring tumor cell repopulation (e.g., through caspase-3-mediated secretion of prostaglandin E ) and confer resistance to anticancer therapy. Accordingly, caution should be exercised in the interpretation of results obtained by the TUNEL and other apoptosis assays (e.g., caspase activation) in terms of apoptotic cell demise.


===MeSH Terms===
|keywords=* four-dimensional spatial-temporal consistency of local neural activity
-
* lifespan
* local functional connectivity
* local functional connectivity density
* resting-state fMRI
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375100
}}
==BHLHE40==


===Keywords===
{{medline-entry
DNA strand breakage; TUNEL; anastasis; apoptosis; cancer therapy; micronucleation; polyploid giant cancer cells; reversal; senescence
|title=Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32360904


==Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging.==
|mesh-terms=* Basic Helix-Loop-Helix Transcription Factors
===Abstract===
* Cell Line, Tumor
Continuous circulation and drainage of cerebrospinal fluid (CSF) are essential for the elimination of CSF-borne metabolic products and neuronal function. While multiple CSF drainage pathways have been identified, the significance of each to normal drainage and whether there are differential changes at CSF outflow regions in the aging brain are unclear. Dynamic in vivo imaging of near infrared fluorescently-labeled albumin was used to simultaneously visualize the flow of CSF at outflow regions on the dorsal side (transcranial and -spinal) of the central nervous system. This was followed by kinetic analysis, which included the elimination rate constants for these regions. In addition, tracer distribution in ex vivo tissues were assessed, including the nasal/cribriform region, dorsal and ventral surfaces of the brain, spinal cord, cranial dura, skull base, optic and trigeminal nerves and cervical lymph nodes. Based on the in vivo data, there was evidence of CSF elimination, as determined by the rate of clearance, from the nasal route across the cribriform plate and spinal subarachnoid space, but not from the dorsal dural regions. Using ex vivo tissue samples, the presence of tracer was confirmed in the cribriform area and olfactory regions, around pial blood vessels, spinal subarachnoid space, spinal cord and cervical lymph nodes but not for the dorsal dura, skull base or the other cranial nerves. Also, ex vivo tissues showed retention of tracer along brain fissures and regions associated with cisterns on the brain surfaces, but not in the brain parenchyma. Aging reduced CSF elimination across the cribriform plate but not that from the spinal SAS nor retention on the brain surfaces. Collectively, these data show that the main CSF outflow sites were the nasal region across the cribriform plate and from the spinal regions in mice. In young adult mice, the contribution of the nasal and cribriform route to outflow was much higher than from the spinal regions. In older mice, the contribution of the nasal route to CSF outflow was reduced significantly but not for the spinal routes. This kinetic approach may have significance in determining early changes in CSF drainage in neurological disorder, age-related cognitive decline and brain diseases.
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p15
* Homeodomain Proteins
* Humans
* Male
* Prostatic Neoplasms
* Thyroid Hormones
|keywords=* BHLHE40
* Cellular senescence
* DEC1
* Prostate cancer
* Thyroid hormone
|full-text-url=https://sci-hub.do/10.1016/j.jsbmb.2020.105689
}}
==BLM==


===MeSH Terms===
{{medline-entry
-
|title=[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895132


===Keywords===
|mesh-terms=* Cell Movement
Aging brain; CSF; CSF dynamics; CSF elimination rate constants; CSF outflow; Dural CSF drainage; Interstitial fluid (ISF); Nasal/across the cribriform plate CSF drainage; Spinal nerves CSF drainage
* Cell Proliferation
* Cells, Cultured
* Humans
* Imidazoles
* Matrix Metalloproteinase 2
* MicroRNAs
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* Tetrazoles
|keywords=* aging
* invasion
* microRNA
* migration
* olmesartan
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225100
}}
==BMI1==


==Motility in Frail Older Adults: Operationalization of a New Framework and First Insights into Its Relationship with Physical Activity and Life-Space Mobility: An Exploratory Study.==
{{medline-entry
===Abstract===
|title=Senescence Induced by [[BMI1]] Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.
In order to design effective interventions to prevent age-related mobility loss, it is important to identify influencing factors. The concept of "motility" by Kaufmann et al. subdivides such factors into three categories: "access", "skills", and "appropriation". The aim of this study was to assemble appropriate quantitative assessment tools for the assessment of these factors in frail older adults and to get first insights into their relative contribution for life-space and physical activity-related mobility. This is an exploratory cross-sectional study conducted with twenty-eight at least prefrail, retired participants aged 61-94. Life-space mobility was assessed using the "University of Alabama at Birmingham Life-space Assessment" (LSA) and physical activity using the "German Physical Activity Questionnaire" (PAQ50+). Factors from the category "appropriation", followed by factors from the category "skills" showed the strongest associations with the LSA. Factors from the category "access" best explained the variance for PAQ50+. This study's findings indicate the importance of accounting for and examining comprehensive models of mobility. The proposed assessment tools need to be explored in more depth in longitudinal studies with larger sample sizes in order to yield more conclusive results about the appropriateness of the motility concept for such purposes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33086074


===MeSH Terms===
-


===Keywords===
|keywords=* BH3 mimetics
aging; frailty; life-space assessment; mobility determinants
* BMI1
* DIPG
* H3K27M mutant
* H3WT
* PTC 028
* RNAi screen
* SASP
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574900
}}
==BMP2==


==Cognitive reserve relates to executive functioning in the old-old.==
{{medline-entry
===Abstract===
|title=Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.
Cognitive reserve (CR) is known to reduce or even protect against the negative effects of aging on cognitive functioning. Nonetheless, little is known about how CR influences the relationship between different cognitive abilities and age in the old-old. The goal of the present study was, therefore, to test the hypothesis whether, in the old-old, CR still modifies the relationship between age and cognitive functioning. Eighty-three adults (aged 71-94) without mild cognitive impairment or dementia residing in residential care facilities completed a detailed neuropsychological test battery. CR was estimated using a combination of educational attainment and an estimation of verbal intelligence. Moderation analyses revealed a significant effect for fluency and a trend for flexibility, showing that the negative relationship between age and cognitive performance is reduced as the level of CR increases. These results demonstrate that CR still influences the relationship between age and executive functions in adults of advanced age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32126555


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Aged, 80 and over
* Female
* Humans
* Interleukin-1beta
* Male
* Middle Aged
* Muscle, Smooth, Vascular
* Osteoblasts
|keywords=* Interleukin-1β
* Osteoblastic transition
* Senescence
* Vascular calcification
|full-text-url=https://sci-hub.do/10.1159/000504298
}}
==BMP4==


===Keywords===
{{medline-entry
Aging; Cognitive reserve; Episodic memory; Executive functions; Information processing speed
|title=Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32896271


==Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2  mice.==
===Abstract===
Mitochondrial dysfunction causes energy deficiency and nigrostriatal neurodegeneration which is integral to the pathogenesis of Parkinson disease (PD). Clearance of defective mitochondria involves fission and ubiquitin-dependent degradation via mitophagy to maintain energy homeostasis. We hypothesize that LRRK2 (leucine-rich repeat kinase 2) mutation disrupts mitochondrial turnover causing accumulation of defective mitochondria in aging brain. We found more ubiquitinated mitochondria with aberrant morphology associated with impaired function in aged (but not young) LRRK2  knockin mutant mouse striatum compared to wild-type (WT) controls. LRRK2  mutant mouse embryonic fibroblasts (MEFs) exhibited reduced MAP1LC3/LC3 activation indicating impaired macroautophagy/autophagy. Mutant MEFs under FCCP-induced (mitochondrial uncoupler) stress showed increased LC3-aggregates demonstrating impaired mitophagy. Using a novel flow cytometry assay to quantify mitophagic rates in MEFs expressing photoactivatable [i]mito[/i]-PAmCherry, we found significantly slower mitochondria clearance in mutant cells. Specific LRRK2 kinase inhibition using GNE-7915 did not alleviate impaired mitochondrial clearance suggesting a lack of direct relationship to increased kinase activity alone. DNM1L/Drp1 knockdown in MEFs slowed mitochondrial clearance indicating that DNM1L is a prerequisite for mitophagy. DNM1L knockdown in slowing mitochondrial clearance was less pronounced in mutant MEFs, indicating preexisting impaired DNM1L activation. DNM1L knockdown disrupted mitochondrial network which was more evident in mutant MEFs. DNM1L-Ser616 and MAPK/ERK phosphorylation which mediate mitochondrial fission and downstream mitophagic processes was apparent in WT using FCCP-induced stress but not mutant MEFs, despite similar total MAPK/ERK and DNM1L levels. In conclusion, aberrant mitochondria morphology and dysfunction associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in mutant LRRK2 MEFs and mouse brain.  ATP: adenosine triphosphate; BAX: BCL2-associated X protein; CDK1: cyclin-dependent kinase 1; CDK5: cyclin-dependent kinase 5; CQ: chloroquine; CSF: cerebrospinal fluid; DNM1L/DRP1: dynamin 1-like; ELISA: enzyme-linked immunosorbent assay; FACS: fluorescence-activated cell sorting; FCCP: carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; LAMP2A: lysosomal-associated membrane protein 2A; LRRK2: leucine-rich repeat kinase 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAPK1/ERK2: mitogen-activated protein kinase 1; MEF: mouse embryonic fibroblast; MFN1: mitofusin 1; MMP: mitochondrial membrane potential; PAmCherry: photoactivatable-mCherry; PD: Parkinson disease; PINK1: PTEN induced putative kinase 1; PRKN/PARKIN: parkin RBR E3 ubiquitin protein ligase; RAB10: RAB10, member RAS oncogene family; RAF: v-raf-leukemia oncogene; SNCA: synuclein, alpha; TEM: transmission electron microscopy; VDAC: voltage-dependent anion channel; WT: wild type; SQSTM1/p62: sequestosome 1.


===MeSH Terms===
|keywords=* aging
-
* direct reprogramming
* endothelial cell
* human
* hutchinson-gilford progeria syndrome
* medicine
* mouse
* smooth muscle cell
* vascular barrier
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478891
}}
==BMP7==


===Keywords===
{{medline-entry
Aging; Dnm1l/DRP1; SQSTM1/p62; knockin mice; macroautophagy; mitochondria dysfunction; mitochondrial fission; mitophagy; parkinson disease; ubiquitination
|title=Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting [[BMP7]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31829291


==An Updated Review: Androgens and Cognitive Impairment in Older Men.==
|mesh-terms=* Aging
===Abstract===
* Animals
Androgens are some of the most important sex hormones in men, and they maintain important physiological activities in the human body. Cognitive impairment is one of the most common manifestations of aging in the elderly population and an important factor affecting the quality of life of elderly individuals. The levels of sex hormones in elderly people decrease with age, and low levels of androgens in older male individuals have been closely linked to the development of cognitive impairment. Basic studies have shown that androgens have neuroprotective effects and that androgen deficiency impairs cognitive function by increasing oxidative stress and decreasing synaptic plasticity, among other effects. Additionally, clinical studies have also shown that androgen deficiency is closely related to cognitive impairment. This article reviews the relationship between low androgen levels and cognitive impairment, their potential mechanisms, and the effects of testosterone supplementation in improving cognition.
* Base Sequence
* Bone Morphogenetic Protein 7
* Down-Regulation
* Glycerophosphates
* MicroRNAs
* Models, Biological
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* Osteogenesis
* Rats
|keywords=* Aging
* Mir-542-3p
* Osteogenic differentiation
* Vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907335
}}
==BOC==


===MeSH Terms===
{{medline-entry
-
|title=Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32140711


===Keywords===
|mesh-terms=* Aged
aging; androgen; cognitive impairment; molecular mechanism; older men
* Aging
* Amino Acids
* Body Weight
* China
* Dietary Proteins
* Energy Intake
* Energy Metabolism
* Female
* Humans
* Male
* Nutritional Requirements
* Oxidation-Reduction
* Phenylalanine
* Recommended Dietary Allowances
* Tyrosine
|keywords=* indicator amino acid oxidation
* older adults
* phenylalanine oxidation
* protein requirement
* stable isotope
|full-text-url=https://sci-hub.do/10.1093/jn/nxaa031
}}
==BPI==


==The Prevalence of Sarcopenic Obesity in Postmenopausal Women with a History of Breast Cancer Depending on Adopted Methodology - A Case-Control Study.==
{{medline-entry
===Abstract===
|title=High TARC plasma levels confer protection to long living individuals by inducing M2 profile.
Sarcopenic obesity (SO) is characterized as the cooccurrence of sarcopenia and obesity. It is associated with many adverse health consequences, also in oncological patients. The study aimed to assess the prevalence of SO in postmenopausal women with a history of breast cancer depending on adopted methodology. The case-control study enrolled 103 women over the age of 50 with a history of breast cancer, including women who completed oncological treatment and had remained in remission for at least 5 years (group I, n=78) and women in whom the disease recurred (group II, n=25). The control group included women with no history of breast cancer (group III, n=73). In group II sarcopenia occurred significantly more commonly compared to both group I and the control group (for the skeletal muscle index (SMI) ≤29.20%: 13 (52%) in group II vs 16 (20.5%) in group I, p=0.004 and 3 (4.1%) in group III, p<0.001; for SMI ≤26.60%: 10 (40%) in group II vs 9 (11.5%) in group I, p=0.003 and 3 (4.1%) in group III, p<0.001; for SMI ≤33.87%: 17 (68%) in group II vs 21 (26.9%) in group I, p<0.001 and 5 (6.8%) in group III, p<0.001). Depending on the assessment criteria, SO was diagnosed in 0-11.5% of cases in group I, 0-40% of cases in group II and 0-4.1% in the control group. Intergroup differences were not statistically significant, irrespective of the adopted pair of diagnostic criteria. The highest detectability of SO was observed when SMI was combined with each of the diagnostic criteria for obesity used. SO diagnosis based on the percentage of fatty tissue mass in the body of >38% and SMI value were associated with a higher detection rate of SO in each study group, regardless of the adopted cut-off value. Similar results were obtained in each analyzed group when using the remaining diagnostic criteria for obesity and SMI value, regardless of the cut-off value.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002742


===MeSH Terms===
-


===Keywords===
|keywords=* FACS
aging; breast neoplasms; menopause; muscles; obesity; sarcopenia
* Longevity
* M2 macrophages
* Plasma profile
* TARC
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155305
}}
{{medline-entry
|title=Circulating [[BPI]]FB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32547549


==Association of [i]APOE[/i] E2 and low-density lipoprotein with depressive symptoms in Chinese senile schizophrenia inpatients: A cross-sectional study.==
===Abstract===
Schizophrenia is considered to occur due to both environmental and genetic factors. Depressive symptoms and apolipoprotein E ([i]APOE[/i]) gene polymorphisms are involved in the pathogenesis of schizophrenia. However, the effect of [i]APOE[/i] gene polymorphism on depressive symptoms has never been investigated among Chinese elderly schizophrenia patients. This cross-sectional study aimed to determine the effect of [i]APOE[/i] gene polymorphism on blood lipid metabolism and depressive symptoms among elderly schizophrenia patients. A total of 301 elderly schizophrenia patients (161 males, age ranges from 60 to 92 years, with an average age of 67.31 ± 6.667) were included in the study. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS). [i]APOE[/i] gene polymorphisms were determined by polymerase chain reaction (PCR). Correlations between GDS and serum low-density lipoprotein (LDL) levels with [i]APOE[/i] genotypes were assessed. The concentration of LDL in the [i]APOE[/i] E2 group was significantly lower than those in the [i]APOE[/i] E3 and [i]APOE[/i] E4 groups, and the GDS scores in the [i]APOE[/i] E2 and [i]APOE[/i] E3 groups were higher than those in the [i]APOE[/i] E4 group. Using partial correlation analysis and controlling the duration of disease and hyperlipidemia, we found that GDS scores were significantly correlated with LDL ([i]r[/i] = -0.179, [i]p[/i] = 0.025). [i]The APOE[/i] E2 genotype is associated with more depressive symptoms and lower serum LDL in elderly Chinese schizophrenia patients, and there is a negative correlation between depressive symptoms and LDL.


===MeSH Terms===
|keywords=* FACS
-
* M2 macrophages
* immunity
* longevity
* patrolling-monocytes
* plasma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272600
}}
==BPIFB4==


===Keywords===
{{medline-entry
APOE; Aging; Chinese; Depressive symptoms; Schizophrenia
|title=New Insights for [[BPIFB4]] in Cardiovascular Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32998388


==Interaction of Age and Self-reported Physical Sports Activity on White Matter Hyperintensity Volume in Healthy Older Adults.==
===Abstract===
Cerebral white matter (WM) lesion load, as measured by white matter hyperintensity (WMH) volume with magnetic resonance imaging (MRI), has been associated with increasing age and cardiovascular risk factors, like hypertension. Physical sports activity (PSA) may play an important role in maintaining WM in the context of healthy aging. In 196 healthy older adults, we investigated whether participants reporting high levels of PSA ([i]n[/i] = 36) had reduced total and regional WMH volumes compared to those reporting low levels of PSA ([i]n[/i] = 160). Age group [young-old (YO) = 50-69 years; old-old (OO) = 70-89 years], PSA group, and age by PSA group interaction effects were tested, with sex, hypertension, and body mass index (BMI) as covariates. We found significant main effects for age group and age by PSA group interactions for total, frontal, temporal, and parietal WMH volumes. There were no main effects of PSA group on WMH volumes. The OO group with low PSA had greater total, frontal, temporal, and parietal WMH volumes than the YO with low PSA and OO with high PSA groups. WMH volumes for the YO and OO groups with high PSA were comparable. These findings indicate an age group difference in those with low PSA, with greater WMH volumes in older adults, which was not observed in those with high PSA. The results suggest that engaging in high levels of PSA may be an important lifestyle factor that can help to diminish WMH lesion load in old age, potentially reducing the impact of brain aging.


===MeSH Terms===
|keywords=* BPIFB4
-
* aging
* cardiovascular disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583974
}}
{{medline-entry
|title=LAV-[[BPIFB4]] associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31461407


===Keywords===
|mesh-terms=* Aged
MRI; healthy aging; moderate to vigorous physical activity (MVPA); physical activity (exercise); regional white matter lesion load; white matter (WM); white matter hyperintensity volume
* Aged, 80 and over
* Aging
* Animals
* Female
* Frailty
* Gene Expression Regulation
* Genotype
* Humans
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Phosphoproteins
* Specific Pathogen-Free Organisms
|keywords=* BPIFB4
* aging
* frailty
* longevity-associated variant-lav
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738439
}}
==BRAF==


==Mapping and understanding the decision-making process for providing nutrition and hydration to people living with dementia: a systematic review.==
{{medline-entry
===Abstract===
|title=Conditional reprograming culture conditions facilitate growth of lower grade glioma models.
This systematic review aimed to explore the process of decision-making for nutrition and hydration for people living with dementia from the perspectives and experiences of all involved. We searched CINAHL, the Cochrane Library, EMBASE, MEDLINE and PsycINFO databases. Search terms were related to dementia, decision-making, nutrition and hydration. Qualitative, quantitative and case studies that focused on decision-making about nutrition and hydration for people living with dementia were included. The CASP and Murad tools were used to appraise the quality of included studies. Data extraction was guided by the Interprofessional Shared Decision Making (IP-SDM) model. We conducted a narrative synthesis using thematic analysis. PROSPERO registration number CRD42019131497. Forty-five studies were included (20 qualitative, 15 quantitative and 10 case studies), comprising data from 17 countries and 6020 patients, family caregivers and practitioners. The studies covered a range of decisions from managing oral feeding to the use of tube feeding. We found that decisions about nutrition and hydration for people living with dementia were generally too complex to be mapped onto the precise linear steps of the existing decision-making model. Decision-making processes around feeding for people living with dementia were largely influenced by medical evidence, personal values, cultures and organizational routine. Although the process involved multiple people, family caregivers and non-physician practitioners were often excluded in making a final decision. Upon disagreement, nutrition interventions were sometimes delivered with conflicting feelings concealed by family caregivers or practitioners. Most conflicts and negative feelings were resolved by good relationship, honest communication, multidisciplinary team meetings and renegotiation. The decision-making process regarding nutrition and hydration for people living with dementia does not follow a linear process. It needs an informed, value-sensitive, and collaborative process. However, it often characterized by unclear procedures and with a lack of support. Decisional support is needed and should be approached in a shared and stepwise manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258947


===MeSH Terms===
-


===Keywords===
|keywords=* BRAFV600E
Aging; Alzheimer’s disease; Decision making; Dehydration; Dementia; Feeding methods; Nutrition; Systematic review
* Conditional reprogramming
* NF1
* Senescence
* low grade glioma
|full-text-url=https://sci-hub.do/10.1093/neuonc/noaa263
}}
{{medline-entry
|title=Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202284


==Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.==
===Abstract===
The interrelation of the processes of immunity and senescence now receives an unprecedented emphasis during the COVID-19 pandemic, which brings to the fore the critical need to combat immunosenescence and improve the immune function and resilience of older persons. Here we review the historical origins and the current state of the science of innate and adaptive immunity in aging and longevity. From the modern point of view, innate and adaptive immunity are not only affected by aging but also are important parts of its underlying mechanisms. Excessive levels or activity of antimicrobial peptides, C-reactive protein, complement system, TLR/NF-κB, cGAS/STING/IFN 1,3 and AGEs/RAGE pathways, myeloid cells and NLRP3 inflammasome, declined levels of NK cells in innate immunity, thymus involution and decreased amount of naive T-cells in adaptive immunity, are biomarkers of aging and predisposition factors for cellular senescence and aging-related pathologies. Long-living species, human centenarians, and women are characterized by less inflamm-aging and decelerated immunosenescence. Despite recent progress in understanding, the harmonious theory of immunosenescence is still developing. Geroprotectors targeting these mechanisms are just emerging and are comprehensively discussed in this article.


===MeSH Terms===
|keywords=* Cobimetinib (PubChem CID: 16222096)
-
* MEK
* Nirogacestat (PubChem CID:46224413)
* Notch
* Senescence
* Uveal melanoma
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2020.111006
}}
{{medline-entry
|title=Mitochondrial metabolic reprograming via [[BRAF]] inhibition ameliorates senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31421186


===Keywords===
|mesh-terms=* Cell Proliferation
adaptive immunity; aging; innate immunity; longevity; resilience
* Cells, Cultured
* Cellular Reprogramming
* Cellular Senescence
* Drug Evaluation, Preclinical
* Humans
* Mitochondria
* Proto-Oncogene Proteins B-raf
|keywords=* BRAF
* Metabolic reprogramming
* Mitochondrial function
* SB590885
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110691
}}
==BRD2==


==The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters.==
{{medline-entry
===Abstract===
|title=Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.
One of the most important functions of skin is to act as a protective barrier. To fulfill this role, the structural integrity of the skin depends on the dermal-epidermal junction-a complex network of extracellular matrix macromolecules that connect the outer epidermal layer to the underlying dermis. This junction provides both a structural support to keratinocytes and a specific niche that mediates signals influencing their behavior. It displays a distinctive microarchitecture characterized by an undulating pattern, strengthening dermal-epidermal connectivity and crosstalk. The optimal stiffness arising from the overall molecular organization, together with characteristic anchoring complexes, keeps the dermis and epidermis layers extremely well connected and capable of proper epidermal renewal and regeneration. Due to intrinsic and extrinsic factors, a large number of structural and biological changes accompany skin aging. These changes progressively weaken the dermal-epidermal junction substructure and affect its functions, contributing to the gradual decline in overall skin physiology. Most changes involve reduced turnover or altered enzymatic or non-enzymatic post-translational modifications, compromising the mechanical properties of matrix components and cells. This review combines recent and older data on organization of the dermal-epidermal junction, its mechanical properties and role in mechanotransduction, its involvement in regeneration, and its fate during the aging process.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559200


===MeSH Terms===
|mesh-terms=* Animals
-
* Female
* Fertility
* Grooming
* Haploinsufficiency
* Kidney
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* Transcription Factors


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304595
aging; basement membrane; dermal papilla; dermal-epidermal junction; epidermal rete-ridge; extracellular matrix; mechanical properties; skin
}}
==BRD4==


==Cellular and molecular features of senescence in acute lung injury.==
{{medline-entry
===Abstract===
|title=Inhibition of [[BRD4]] triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.
A wide range of insults can trigger acute injury in the lungs, which eventually may lead to respiratory failure and death of patients. Current treatment relies mainly on supportive measures and mechanical ventilation. Even so, survivors frequently develop important sequels that compromise quality of life. In the search for new approaches to prevent and treat acute lung injury, many investigations have focused on molecular and cellular pathways which could exert a pathogenic role in this disease. Herein, we review recent findings in the literature suggesting that cellular senescence could be involved in lung injury and discuss the potential use of senotherapies to prevent disease progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32954665


===MeSH Terms===
-


===Keywords===
|keywords=* BRD4
Acute lung injury; Acute respiratory distress syndrome; Senescence
* aurora kinase
* cellular senescence
* oesophageal cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701500
}}
{{medline-entry
|title=[[BRD4]] contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32392533


==Dilated cardiomyopathy impairs mitochondrial biogenesis and promotes inflammation in an age- and sex-dependent manner.==
===Abstract===
Dilated cardiomyopathy (DCM) belongs to the myocardial diseases associated with a severe impairment of cardiac function, but the question of how sex and age affect this pathology has not been fully explored. Impaired energy homeostasis, mitochondrial dysfunction, and systemic inflammation are well-described phenomena associated with aging. In this study, we investigated if DCM affects these phenomena in a sex- and age-related manner. We analyzed the expression of mitochondrial and antioxidant proteins and the inflammatory state in DCM heart tissue from younger and older women and men. A significant downregulation of Sirt1 expression was detected in older DCM patients. Sex-related differences were observed in the phosphorylation of AMPK that only appeared in older males with DCM, possibly due to an alternative Sirt1 regulation mechanism. Furthermore, reduced expression of several mitochondrial proteins (TOM40, TIM23, Sirt3, and SOD2) and genes ([i]cox1[/i], [i]nd4[/i]) was only detected in old DCM patients, suggesting that age has a greater effect than DCM on these alterations. Finally, an increased expression of inflammatory markers in older, failing hearts, with a stronger pro-inflammatory response in men, was observed. Together, these findings indicate that age- and sex-related increased inflammation and disturbance of mitochondrial homeostasis occurs in male individuals with DCM.


===MeSH Terms===
|keywords=* BRD4
-
* gene expression
* inflammation
* macrophage
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288959
}}
{{medline-entry
|title=BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561444


===Keywords===
|mesh-terms=* Animals
aging; dilated cardiomyopathy; inflammation; mitochondrial proteins; sex differences
* Cell Cycle Proteins
* Cellular Senescence
* Diabetes Mellitus, Type 1
* Female
* Humans
* Insulin-Secreting Cells
* Islets of Langerhans
* Mice
* Mice, Inbred NOD
* Paracrine Communication
* Protein Binding
* Transcription Factors
* Transcriptional Activation
|keywords=* BET proteins
* beta cells
* senescence and SASP
* type 1 diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801956
}}
==BTK==


==Bioinformatics analysis of autophagy-lysosomal degradation in cardiac aging.==
{{medline-entry
===Abstract===
|title=Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.
Cardiac aging, which causes cardiac diastolic dysfunction, frequently occurs in older people. The role of autophagy in cardiac aging is the subject of intensive research. Autophagy comprises steps called the autophagosome formation and autophagosome-lysosome fusion. Caloric restriction (CR) is the gold standard used to induce autophagosome formation, and autophagosome-lysosome fusion is reduced by aging. However, few studies are available that survey and compare signaling during CR (autophagosome formation induced status) and old (potentially autophagosome-lysosome fusion-reduced status). Here we aimed to identify the rate-limiting step of autophagic disorders during cardiac aging. We employed bioinformatics to analyze publicly available DNA microarray datasets. The first dataset compared the hearts of young and old C57BL6 mice (OLD). The second dataset compared the hearts of young C57BL6 mice fed a normal diet with those of young C57BL6 mice subjected to CR. We analyzed OLD-upregulated genes that were significantly associated with the Gene Ontogeny term "Autophagy," indicating that autophagic genes were upregulated in OLD mice. The autophagy-related gene Atg5 and Atg5-related genes were upregulated in OLD and CR mice. The identified hub and bottleneck genes are autophagic autophagosome formation suppressors such as Sirt2, Ilk and Islr, as well as the autophagosome-lysosome fusion inducer Snapin. Autophagosome formation genes were upregulated in aging mice subjected to CR, indicating that an upregulated autophagosome formation is not a change specific to cardiac aging. However, autophagosome-lysosome fusion genes, particularly the lysosome transportation-related gene Snapin, were downregulated in aging, indicating that autophagosome-lysosome fusion may cause autophagic disorders in cardiac aging. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2020; ••: ••-••.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736210


===MeSH Terms===
-


===Keywords===
|keywords=* BTK
aging; autophagy; cardiology; computational biologyly; sosomes
* cellular senescence
* healthspan
* p53
* progeria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974713
}}
==C2==


==Bridging the gap between serum biomarkers and biomechanical tests in musculoskeletal ageing.==
{{medline-entry
===Abstract===
|title=[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats].
Musculoskeletal ageing is a major public health interesting and strain due to the significant demographic modifications in the population, and it is linked to high risk of falls, loss of autonomy in elderly individuals and institutionalization with small health outcomes. Thus, this pathological status is related to high morbidity and health care rates. Bone mass and muscle mass and strength increase during late adolescence and early adulthood but start to reduce noticeably from the fifth decade of life and are closely linked. Preclinical and clinical data strongly support the muscle-bone cross-talk showing the presence of many tissue-specific factors released by the muscle that modulate bone, such as insulin-like growth factor-1 (IGF- 1), IL-6, IL-15, myostatin and irisin. Bone and muscle tissues were increasingly recognized as endocrine target organs and endocrine organs themselves, interacting through paracrine and endocrine signals. It is then plausible that laboratory parameters could be involved in sarcopenia and osteoporosis diagnosis and treatment monitoring. This narrative review raises the possibility of whether this poor correlation between different muscle/lean mass assessment methods and muscle function tests could suggest that each parameter evaluates different aspects of "muscle status" or "muscle quality". If this is true, no one test can be used to assess muscle status but rather a battery of tests is necessary for a comprehensive assessment. More research is required to provide information for researchers to optimally design studies by using the muscle assessment method that is best associated with selected specific outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744013


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Male
* Membrane Potential, Mitochondrial
* Mitochondria, Muscle
* Muscle, Skeletal
* Physical Conditioning, Animal
* Rats
* Rats, Sprague-Dawley
* Resistance Training
|keywords=* fusion protein 2
* mitochondria
* quadriceps
* rats
* resistance training
|full-text-url=https://sci-hub.do/10.12047/j.cjap.5861.2020.037
}}
{{medline-entry
|title=Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase [[C2]] domain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31972387


===Keywords===
|mesh-terms=* Animals
aging; biomarker; frailty; gait; osteoporosis; sarcopenia; serum
* C2 Domains
* Lycopersicon esculentum
* Phosphatidylinositol 3-Kinase
* Plants, Genetically Modified
* Protein Binding
* Tobacco
|keywords=* C2 domain
* Membrane binding
* Phosphatidylinositol 3-kinase
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.plaphy.2020.01.014
}}
==C3==


==Postural Control While Walking Interferes With Spatial Learning in Older Adults Navigating in a Real Environment.==
{{medline-entry
===Abstract===
|title=Inverse association between periumbilical fat and longevity mediated by complement [[C3]] and cardiac structure.
Cognitive demands for postural control increase with aging and cognitive-motor interference (CMI) exists for a number of walking situations, especially with visuo-spatial cognitive tasks. Such interference also influences spatial learning abilities among older adults; however, this is rarely considered in research on aging in spatial navigation. We posited that visually and physically exploring an unknown environment may be subject to CMI for older adults. We investigated potential indicators of postural control interfering with spatial learning. Given known associations between age-related alterations in gait and brain structure, we also examined potential neuroanatomical correlates of this interference. Fourteen young and 14 older adults had to find an invisible goal in an unfamiliar, real, ecological environment. We measured walking speed, trajectory efficiency (direct route over taken route) and goal fixations (proportion of visual fixations toward the goal area). We calculated the change in walking speed between the first and last trials and adaptation indices for all three variables to quantify their modulation across learning trials. All participants were screened with a battery of visuo-cognitive tests. Eighteen of our participants (10 young, 8 older) also underwent a magnetic resonance imaging (MRI) examination. Older adults reduced their walking speed considerably on the first, compared to the last trial. The adaptation index of walking speed correlated positively with those of trajectory efficiency and goal fixations, indicating a reduction in resource sharing between walking and encoding the environment. The change in walking speed correlated negatively with gray matter volume in superior parietal and occipital regions and the precuneus. We interpret older adults' change in walking speed as indicative of CMI, similar to dual task costs. This is supported by the correlations between the adaptation indices and between the change in walking speed and gray matter volume in brain regions that are important for navigation, given that they are involved in visual attention, sensory integration and encoding of space. These findings under ecological conditions in a natural spatial learning task question what constitutes dual tasking in older adults and they can lead future research to reconsider the actual cognitive burden of postural control in aging navigation research.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221761


===MeSH Terms===
-


===Keywords===
|keywords=* abdominal obesity
aging; brain atrophy; cognitive-motor interference; navigation; parietal cortex; postural control; spatial learning; walking speed
* cardiac structure
* complement C3
* longevity
* periumbilical fat
|full-text-url=https://sci-hub.do/10.18632/aging.104113
}}
{{medline-entry
|title=Complement [[C3]] deficiency ameliorates aging related changes in the kidney.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882264


==Weather Woes? Exploring Potential Links between Precipitation and Age-Related Cognitive Decline.==
|mesh-terms=* Aging
===Abstract===
* Animals
Rain, snow, or ice may discourage older adults from leaving their homes with potential consequences for social isolation, decreased physical activity, and cognitive decline. This study is the first to examine potential links between annual precipitation exposure and cognitive function in a large population-based cohort of older Americans. We examined the association between precipitation (percent of days with snow or rain in the past year) and cognitive function in 25,320 individuals aged 45+ from the Reasons for Geographic and Racial Differences in Stroke Study. Linear mixed models assessed the relationship between precipitation and cognitive function, as well as rates of change in cognitive function with age. We found a non-linear relationship between precipitation and cognitive function. Compared to those exposed to infrequent precipitation (less than 20% of days with rain/snow in the past year), cognitive function was higher among older adults experiencing moderately frequent precipitation (20-40% of annual days with precipitation). However, beyond more than about 45% of days with precipitation in the past year, there was a negative association between precipitation and cognitive function, with faster rates of cognitive decline with age. These exploratory findings motivate further research to better understand the complex role of precipitation for late-life cognitive function.
* Complement C3
* Inflammation
* Kidney
* Kidney Diseases
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
|keywords=* Complement component 3
* Kidney disorder
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118370
}}
{{medline-entry
|title=Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32087947


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Brain
* Homeostasis
* Immunity, Innate
* Mice, Transgenic
* Neurons
* Racemases and Epimerases
* Sialic Acid Binding Immunoglobulin-like Lectins
* Sialic Acids
* Synapses
|keywords=* Aging
* GNE
* Glycocalyx
* Microglia
* Neurodegeneration
* Neuroinflammation
* Sialic acid
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.008
}}
{{medline-entry
|title=[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512417


===Keywords===
|mesh-terms=* Animals
aging; climate; cognitive function; environment; longitudinal
* Antioxidants
* Female
* Longevity
* Male
* Mice
* Mice, Inbred BALB C
* Polyphenols
* Survival Analysis
|keywords=* BP-C3
* Gompertz model
* SkQ1
* aging
* herbal extracts
* lifespan
* metformin
* polyphenols
* resveratrol
* tocopherol


==Review of How Genetic Research on Segmental Progeroid Syndromes Has Documented Genomic Instability as a Hallmark of Aging But Let Us Now Pursue Antigeroid Syndromes!==
}}
===Abstract===
==C5==
The purpose of this early contribution to the new Fellows Forum of this pioneering journal for what is now called Geroscience is to provide an example of how the author's interest in using the emerging tools of human genetics has led to strong support for one of the hallmarks of aging-Genomic Instability. We shall also briefly review our emerging interests in the genetic analysis of what we have called Antigeroid Syndromes. While there has been significant progress in that direction via genetic studies of centenarians, the search for genetic pathways that make individuals unusually resistant or resilient to the ravages of specific geriatric disorders has been comparatively neglected. We refer to these disorders as Unimodal Antigeroid Syndromes. It is our hope that our young colleagues will consider research efforts in that direction.


===MeSH Terms===
{{medline-entry
-
|title=The [[C5]]-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32638663


===Keywords===
Human aging; Human genetics; Longevity; Progeroid syndromes


==Medical Cannabis Use: Exploring the Perceptions and Experiences of Older Adults with Chronic Conditions.==
|keywords=* aging
===Abstract===
* case-finding
: Although the rate of cannabis use by older adults is increasing more quickly than all other age groups, little is known about the reasons older adults use cannabis and the outcomes they experience. With this research, we investigated older adults' perceptions and experiences of medical cannabis use to treat and/or manage chronic conditions, specifically as a substitute for prescription drugs. : Researchers relied on qualitative inquiry in the form of semi-structured, one-on-one interviewing to investigate the phenomenon of medical cannabis use for the management of chronic conditions.  : Our findings suggest that older adults are open to medical cannabis as an alternative to pharmaceutical drugs, hopeful with regard to the management of symptoms and pain, and aware of and astute at managing issues related to stigma both from their physicians and family and friends. Furthermore, older adults describe the frustrations with education, awareness, and lack of support with dosing.  : Participations found medical cannabis use to be beneficial in managing chronic conditions and alleviating symptoms such as chronic pain. Findings are presented as an interpretation of the participants' perceptions of their medical cannabis use. Implications for putting medical cannabis use into everyday practice as well as policy implications are considered. : This information will help clinicians better support older adults desiring to use medical cannabis. This research will help clinicians learn more about factors impacting medical cannabis use, and the types of information and assistance that may aid older adults in their health and well-being with the use of medical cannabis to treat chronic conditions.
* co-morbid conditions
* comorbidité
* dépistage
* fragilité
* frailty
* primary care
* recherche de cas
* screening
* soins de première ligne
* vieillissement
|full-text-url=https://sci-hub.do/10.1017/S0714980820000161
}}
{{medline-entry
|title=Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590805


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Cervical Vertebrae
* Female
* Geriatrics
* Humans
* Japan
* Magnetic Resonance Imaging
* Male
* Paralysis
* Severity of Illness Index
* Spinal Canal
* Spinal Cord
* Spinal Cord Injuries
* Tomography, X-Ray Computed
* Wounds and Injuries


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328921
Aging; health; medical cannabis; qualitative methods
}}
==C6==


==Vestibular function modulates the impact of nGVS on postural control in older adults.==
{{medline-entry
===Abstract===
|title=Evolution of the Aroma of Treixadura Wines during Bottle Aging.
Previous studies have reported an important relationship between increasing age, vestibular impairment and increased risk of falls. Recently, noisy galvanic vestibular stimulation (nGVS) has been shown to improve postural control in older adults. However, this effect of nGVS in older adults has not been examined in interaction with the integrity of the vestibular function. We aimed at determining the effect of nGVS on postural control in older adults with and without vestibular impairment and ii) at examining the sustained effect of nGVS as compared to a sham stimulation. 36 older adults were randomly assigned to the nGVS group [n=24] or the sham group [n=12]. In the nGVS group, 12 participants had normal vestibular function and 12 had vestibular impairment. Static postural control was assessed prior to stimulation, during stimulation and immediately following 30 minutes of nGVS. Results showed that nGVS induced a significant improvement in sway velocity (p<0.001) and path length (p<0.001) compared to sham stimulation. In the nGVS group, participants with vestibular impairment showed a significant decrease of sway velocity (p<0.05) and path length (p<0.05) as compared to those with normal vestibular function. Improvements in sway velocity (p<0.001) and path length (p<0.001) induced by nGVS were sustained immediately following stimulation. These findings suggest that nGVS improves postural control in older adults, and that the effect of nGVS varies depending on the integrity of the vestibular function. Results also show that nGVS effect on postural control, compared to a sham stimulation, can be sustained after the end of stimulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049919


===MeSH Terms===
-


===Keywords===
|keywords=* bottle aging
Aging; Noisy galvanic vestibular stimulation; Postural control; Vestibular function; Vestibular system
* flavor profile
* sensory evaluation
* volatile composition
* white wine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600726
}}
{{medline-entry
|title=D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32991321


==Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.==
===Abstract===
Fluid intelligence (FI) involves abstract problem-solving without prior knowledge. Greater age-related FI decline increases Alzheimer's disease (AD) risk, and recent studies suggest that certain dietary regimens may influence rates of decline. However, it is uncertain how long-term food consumption affects FI among adults with or without familial history of AD (FH) or APOE4 (ɛ4). Observe how the total diet is associated with long-term cognition among mid- to late-life populations at-risk and not-at-risk for AD. Among 1,787 mid-to-late-aged adult UK Biobank participants, 10-year FI trajectories were modeled and regressed onto the total diet based on self-reported intake of 49 whole foods from a Food Frequency Questionnaire (FFQ). Daily cheese intake strongly predicted better FIT scores over time (FH-: β= 0.207, p < 0.001; ɛ4-: β= 0.073, p = 0.008; ɛ4+: β= 0.162, p = 0.001). Alcohol of any type daily also appeared beneficial (ɛ4+: β= 0.101, p = 0.022) and red wine was sometimes additionally protective (FH+: β= 0.100, p = 0.014; ɛ4-: β= 0.59, p = 0.039). Consuming lamb weekly was associated with improved outcomes (FH-: β= 0.066, p = 0.008; ɛ4+: β= 0.097, p = 0.044). Among at risk groups, added salt correlated with decreased performance (FH+: β= -0.114, p = 0.004; ɛ4+: β= -0.121, p = 0.009). Modifying meal plans may help minimize cognitive decline. We observed that added salt may put at-risk individuals at greater risk, but did not observe similar interactions among FH- and AD- individuals. Observations further suggest in risk status-dependent manners that adding cheese and red wine to the diet daily, and lamb on a weekly basis, may also improve long-term cognitive outcomes.


===MeSH Terms===
|keywords=* CDK6
-
* D-galatose
* YAP
* cellular senescence
* glioblastoma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585072
}}
==C7==


===Keywords===
{{medline-entry
APOE4; Aging; Mediterranean diet; cognitive decline; functional food; lamb; nutrition policy; preventive medicine; red wine; salt
|title=The Vertebral Artery Convergence to the Cervical Spine in Elders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337923


==Silencing ATG6 and PI3K accelerates petal senescence and reduces flower number and shoot biomass in petunia.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
Petal senescence is a form of developmental programmed cell death (PCD) that is regulated by internal and environmental signals. Autophagy, a metabolic pathway that regulates intercellular nutrient recycling, is thought to play an important role in the regulation of petal senescence-associated PCD. To characterize the function of two central autophagy genes in petal senescence, we down-regulated Autophagy Gene 6 (PhATG6) and Phosphoinositide 3-Kinase (PhPI3K) using Virus-Induced Gene Silencing (VIGS) in Petunia × hybrida. The silencing of PhATG6 and PhPI3K accelerated petal senescence, thereby reducing flower longevity. Both PhATG6- and PhPI3K-silenced petunias had reduced flower numbers, flower biomass, and vegetative shoot biomass. These phenotypes were intensified when plants were grown under low nutrient conditions. Additionally, two important regulators of senescence, an ethylene biosynthesis gene (PhACS) and a type I metacaspase gene (PhMC1), were suppressed in senescing petals of PhATG6- and PhPI3K-silenced plants. In conclusion, our study identified PhATG6 and PhPI3K as negative regulators of flower senescence and demonstrated the influence of nutrient limitation on the function of autophagy during petal senescence. Our study also found that autophagy genes potentially influence the transcriptional regulation of metacaspases and ethylene biosynthetic genes during petal senescence. The results of this project will be fundamental for future studies of petal senescence and will provide genetic information for future crop improvement.
* Aging
* Cervical Vertebrae
* Computed Tomography Angiography
* Cross-Sectional Studies
* Female
* Humans
* Male
* Middle Aged
* Retrospective Studies
* Vertebral Artery
|keywords=*  angiography
*  computed tomography
*  osteoarthritis
*  spine
*  vertebral artery
* aging
|full-text-url=https://sci-hub.do/10.3897/folmed.61.e39418
}}
==C9==


===MeSH Terms===
{{medline-entry
-
|title=[[C9]]orf72 in myeloid cells suppresses STING-induced inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814898


===Keywords===
|mesh-terms=* Aging
Autophagy; Ethylene; Longevity; Metacaspase; Programmed cell death; VIGS
* Amyotrophic Lateral Sclerosis
* Animals
* C9orf72 Protein
* Dendritic Cells
* Encephalomyelitis, Autoimmune, Experimental
* Female
* Humans
* Inflammation
* Interferon Type I
* Membrane Proteins
* Mice
* Myeloid Cells
* Neoplasms
* T-Lymphocytes


==Higher relative effort of the knee relates to faster adaptation in older adults at risk for mobility disability.==
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484469
===Abstract===
}}
Gait adaptation is crucial for adults at risk for mobility disability, and executive function and physical function may be important for adaptation performance. Gait adaptation can be measured using a treadmill with two belts, known as a split-belt treadmill. Increasing evidence supports that gait adaptability, executive function, and physical function are interrelated in older adults. The purpose of this study was to determine if: a) executive function and measures of relative effort of the ankle and knee relate to split-belt treadmill adaptation; b) older adults classified as fast adapters display differences in relative effort, executive function, and propulsive impulse (push-off) compared to slow adapters; and c) spatial and temporal control differ between individuals with faster rate of adaptation compared to those with slower rates of adaptation. Greater effort of the knee on the slow belt was related to faster early adaptation (r = 0.650, p = 0.005) indicating its importance for adapting quickly to the perturbation. We did not observe a relationship between cognitive tests and adaptation performance. We did not detect any statistical differences in cognitive tests performance, push-off, spatial or temporal control between fast adapters compared to slow adapters. Our results suggest that in older adults at risk for mobility disability, higher effort at the knee is important for early split-belt adaptation.
{{medline-entry
|title=Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843021


===MeSH Terms===
|mesh-terms=* Aging
-
* Alanine
* Animals
* Animals, Genetically Modified
* Brain
* C9orf72 Protein
* DNA Repeat Expansion
* Dipeptides
* Drosophila
* Female
* Glycine
|keywords=* Ageing
* C9orf72
* Dipeptide repeat proteins
* Drosophila
* PolyGA
* Repeat size
* Spread
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916080
}}
{{medline-entry
|title=Human iPSC-derived astrocytes from ALS patients with mutated [[C9]]ORF72 show increased oxidative stress and neurotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31787569


===Keywords===
|mesh-terms=* Amyotrophic Lateral Sclerosis
Adaptation; Aging; Cognition; Relative effort; Split-belt; Walking
* Animals
* Astrocytes
* Biomarkers
* C9orf72 Protein
* Cells, Cultured
* Cellular Reprogramming
* Cellular Senescence
* Cerebral Cortex
* Disease Models, Animal
* Gene Expression Profiling
* Glutamic Acid
* Humans
* Induced Pluripotent Stem Cells
* Mice
* Motor Neurons
* Mutation
* Oxidative Stress
* Proteomics
* Reactive Oxygen Species
|keywords=* Amyotrophic lateral sclerosis
* Astrocytes
* Neurotoxicity
* Oxidative stress
* Senescence
* iPSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921360
}}
==C9orf72==


==The Gut-Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing.==
{{medline-entry
===Abstract===
|title=Carriership of two copies of [[C9orf72]] hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population.
The gut microbiota could influence the pathophysiology of age-related sarcopenia through multiple mechanisms implying modulation of chronic inflammation and anabolic resistance. The aim of this study was to compare the fecal microbiota composition and functionality, assessed by shotgun metagenomics sequencing, between two groups of elderly outpatients, differing only for the presence of primary sarcopenia. Five sarcopenic elderly subjects and twelve non-sarcopenic controls, classified according to lower limb function and bioimpedance-derived skeletal muscle index, provided a stool sample, which was analyzed with shotgun metagenomics approaches, to determine the overall microbiota composition, the representation of bacteria at the species level, and the prediction of bacterial genes involved in functional metabolic pathways. Sarcopenic subjects displayed different fecal microbiota compositions at the species level, with significant depletion of two species known for their metabolic capacity of producing short-chain fatty acids (SCFAs), [i]Faecalibacterium prausnitzii[/i] and [i]Roseburia inulinivorans[/i], and of [i]Alistipes shahii[/i]. Additionally, their fecal metagenome had different representation of genes belonging to 108 metabolic pathways, namely, depletion of genes involved in SCFA synthesis, carotenoid and isoflavone biotransformation, and amino acid interconversion. These results support the hypothesis of an association between microbiota and sarcopenia, indicating novel possible mediators, whose clinical relevance should be investigated in future studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168078


===MeSH Terms===
-


===Keywords===
|keywords=* ALS
frailty; geriatrics; gut microbiota; gut–muscle axis; physical function
* Aging
* C9orf72
* Case-control analysis
* Intermediate repeats
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654028
}}
==CA1==


==The Gut Microbiome, Aging, and Longevity: A Systematic Review.==
{{medline-entry
===Abstract===
|title=The relation between tau pathology and granulovacuolar degeneration of neurons.
Aging is determined by complex interactions among genetic and environmental factors. Increasing evidence suggests that the gut microbiome lies at the core of many age-associated changes, including immune system dysregulation and susceptibility to diseases. The gut microbiota undergoes extensive changes across the lifespan, and age-related processes may influence the gut microbiota and its related metabolic alterations. The aim of this systematic review was to summarize the current literature on aging-associated alterations in diversity, composition, and functional features of the gut microbiota. We identified 27 empirical human studies of normal and successful aging suitable for inclusion. Alpha diversity of microbial taxa, functional pathways, and metabolites was higher in older adults, particularly among the oldest-old adults, compared to younger individuals. Beta diversity distances significantly differed across various developmental stages and were different even between oldest-old and younger-old adults. Differences in taxonomic composition and functional potential varied across studies, but [i]Akkermansia[/i] was most consistently reported to be relatively more abundant with aging, whereas [i]Faecalibacterium[/i], [i]Bacteroidaceae[/i], and [i]Lachnospiraceae[/i] were relatively reduced. Older adults have reduced pathways related to carbohydrate metabolism and amino acid synthesis; however, oldest-old adults exhibited functional differences that distinguished their microbiota from that of young-old adults, such as greater potential for short-chain fatty acid production and increased butyrate derivatives. Although a definitive interpretation is limited by the cross-sectional design of published reports, we integrated findings of microbial composition and downstream functional pathways and metabolites, offering possible explanations regarding age-related processes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33069844


===MeSH Terms===
-


===Keywords===
|keywords=* AT8
centenarians; cognition; functional potential; healthy aging; immunosenescence; inflammation; metabolites; microbes
* Aging
* CA1
* Casein kinase 1δ
* Congo red
* Dorsal raphe nucleus
* Locus coeruleus
* Neurodegeneration
* Tau pathology
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2020.105138
}}
{{medline-entry
|title=Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32950615


==Protective effects of saponins from Panax japonicus on neurons of the colon myenteric plexus in aging rats through reduction of α-synuclein through endoplasmic reticulum stress.==
===Abstract===
The enteric nervous system degenerates gradually with age, and α-synuclein (α-syn) is a suitable marker of enteric nervous system degeneration, which is intimately related with endoplasmic reticulum stress and unfolded protein response (UPR  ). Saponins from Panax japonicus (SPJ) have obvious protective effects on neurons in several degenerative disease models. Here, the study was designed to investigate whether SPJ could reverse the neuron degeneration through regulating the UPR  in the colon myenteric plexus of aging rats. Aging rats had been treated with SPJ for 6 months since they were aged 18 months. Then, the colon samples were collected and neuron morphology in the myenteric plexus was observed. Immunohistochemistry staining was used to detect the expressions of NeuN, α-syn, GRP78 and three different UPR  branches. Double immunofluorescence was used to determine the co-localization of α-syn and NeuN, GRP78 and NeuN. Neurons degenerated in the colon myenteric plexus of aging rats, but co-localization of α-syn and NeuN increased. In addition, both the expressions of GRP78 and three UPR  branch signaling pathway proteins decreased in the colon myenteric plexus of aging rats. Treatment of SPJ almost alleviated the above effects in aging rats, except for ATF6. SPJ could reverse the neuron loss caused by accumulation of α-syn in the myenteric plexus of colon in aging rats, which is potentially associated with increased GRP78 and most URP  changes. Geriatr Gerontol Int 2020; ••: ••-••.


===MeSH Terms===
|keywords=* Aging
-
* Hippocampus
* Locomotor activity
* Memory and learning
* Prefrontal cortex
* Pyramidal neurons
* dendritic spines
|full-text-url=https://sci-hub.do/10.1016/j.jchemneu.2020.101858
}}
{{medline-entry
|title=Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887666


===Keywords===
aging; myenteric plexus; saponins from Panax japonicus; unfolded protein response of endoplasmic reticulum; α-synuclein


==Iron Status is Associated with Mood, Cognition, and Functional Ability in Older Adults: A Cross-Sectional Study.==
|keywords=* Amyotrophic lateral sclerosis (ALS)
===Abstract===
* C9ORF72
Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups.
* Dentate gyrus, adult neurogenesis
* Frontotemporal dementia (FTD)
* Klotho
* Long-term depression (LTD)
* Long-term potentiation (LTP)
* Longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473815
}}
{{medline-entry
|title=COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32754029


===MeSH Terms===
-


===Keywords===
|keywords=* BDNF
aging; cognition; iron deficiency; mood; physical functional ability
* COX5A
* ERK1/2
* brain senescence
* memory impairment
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365906
}}
{{medline-entry
|title=Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647628


==U-Shaped Association between Dietary Acid Load and Risk of Osteoporotic Fractures in 2 Populations at High Cardiovascular Risk.==
===Abstract===
Bone contributes to maintaining the acid-base balance as a buffering system for blood pH. Diet composition also affects acid-base balance. Several studies have linked an imbalance in the acid-base system to changes in the density and structure of bone mass, although some prospective studies and meta-analyses suggest that acid load has no deleterious effect on bone. The aim of this study was to examine the associations between potential renal acid load (PRAL) and net endogenous acid production (NEAP) and the risk of osteoporotic fractures and bone mineral density (BMD) in 2 middle-aged and elderly Mediterranean populations. We conducted a longitudinal analysis including 870 participants from the PREvención con DIeta MEDiterranea (PREDIMED) Study and a cross-sectional analysis including 1134 participants from the PREDIMED-Plus study. Participants were adults, aged 55-80 y, either at high cardiovascular risk (PREDIMED) or overweight/obese with metabolic syndrome (PREDIMED-Plus), as defined by the International Diabetes Federation, the American Heart Association, and the National Heart Association. PRAL and NEAP were calculated from validated food-frequency questionnaires. BMD was measured using DXA scans. Fracture information was obtained from medical records. The association between mean PRAL and NEAP and fracture risk was assessed using multivariable-adjusted Cox models. BMD differences between tertiles of baseline PRAL and NEAP were evaluated by means of ANCOVA. A total 114 new fracture events were documented in the PREDIMED study after a mean of 5.2 y of intervention and 8.9 y of total follow-up. Participants in the first and third PRAL and NEAP tertiles had a higher risk of osteoporotic fracture compared with the second tertile, showing a characteristically U-shaped association [HR (95% CI): 1.73 (1.03, 2.91) in tertile 1 and 1.91 (1.14, 3.19) in tertile 3 for PRAL, and 1.83 (1.08, 3.09) in tertile 1 and 1.87 (1.10, 3.17) in tertile 3 for NEAP]. Compared with the participants in tertile 1, the participants in the top PRAL and NEAP tertiles had lower BMD [PRAL: mean total femur BMD: 1.029 ± 0.007 and 1.007 ± 0.007 g/cm2; P = 0.006 (tertiles 1 and 3); NEAP: mean total femur BMD: 1.032 ± 0.007 and 1.009 ± 0.007 g/cm2; P = 0.017 (tertiles 1 and 3)]. The results of our study suggest that both high and low dietary acid are associated with a higher risk of osteoporotic fractures, although only high dietary acid was found to have a negative relation to BMD in senior adults with existing chronic health conditions. This trial was registered at http://www.isrctn.com/ as ISRCTN3573963 (PREDIMED) and ISRCTN89898870 (PREDIMED-Plus).


===MeSH Terms===
|keywords=* Aging
-
* Fto
* Hippocampus
* Mice
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336480
}}
{{medline-entry
|title=Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531811


===Keywords===
aging; bone; bone mineral density; dietary potential acid load; fracture


==Exploration on the effect of predeposit autotransfusion on bone marrow hematopoiesis after femoral shaft fracture.==
|keywords=* aging
===Abstract===
* dendrites
By observing the changes in the number and activity of CD34+ cells in bone marrow after predeposit autotransfusion (PAT) to patients with femoral shaft fracture (FSF), to evaluate the effects of PAT on hematopoietic function and hematopoietic stem cells in bone marrow. Selected FSF patients were randomly divided into 2 groups: the control group (patients did not receive blood transfusion after surgery) and PAT group (patients received PAT after surgery). The content of RBC and Plt in blood samples were counted by blood routine. The cell cycle and proportion of CD34+ myelinated cells in blood samples was analyzed by flow cytometry. The telomere DNA length of hematopoietic stem cells (HSCs) in the control groups and PAT group at postoperation 24 was analyzed by southern blot. The content of RBC and Plt in postoperation 6h and 24h in the control group was evidently higher compared to that in PAT group, while Hb content in control group was significantly lower compared to that in PAT group. The proportion of CD34+ myelinated cells in post-transfusion 6h and postoperation 24h in PAT group was evidently higher compared to that in the control group. In PAT group, S phase at postoperation 24h was significantly larger compared to that at post-transfusion 6h. The telomere DNA length of HSCs in PAT group was longer than that in the control group. PAT can increase the number of HSC, while does not cause the abnormal aging of HSCs. PAT is suitable for postoperative blood transfusion of patients with FSF.
* hippocampus
* memory and learning
* nucleus accumbens
* prefrontal cortex
* sodium phenylbutyrate
|full-text-url=https://sci-hub.do/10.1002/syn.22177
}}
{{medline-entry
|title=Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32501292


===MeSH Terms===
-


===Keywords===
|keywords=* Alzheimer’s disease
Aging; CD34+ myelinated cells; Fracture; HSCs; PAT
* aging
* brain ischemia
* glia
* neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343500
}}
{{medline-entry
|title=Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32376783


==Extracellular vesicles as potential tools for regenerative therapy.==
|mesh-terms=* Animals
===Abstract===
* Cognitive Aging
Small extracellular vesicles released by fibroblasts from young human donors diminish lipid peroxidation in senescent cells and in different old mice organs due to their enrichment in Glutathione-S-transferase Mu lipid antioxidant activity.
* Dentate Gyrus
* Hippocampus
* Maze Learning
* Rats
* Rats, Inbred F344
* Spatial Memory
* Transcriptome
|keywords=* aging
* hippocampus
* pattern separation
* reference memory
* spatial discrimination
* transcription
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326352
}}
{{medline-entry
|title=Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32371923


===MeSH Terms===
|mesh-terms=* Adult
-
* Age Factors
* Aged
* Brain Mapping
* Female
* Hippocampus
* Humans
* Longevity
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Young Adult


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200747
Small extracellular vesicles; aging; glutathione-S-transferase M; lipid peroxidation; senescence
}}
{{medline-entry
|title=Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326571


==Sarcopenia: Molecular Pathways and Potential Targets for Intervention.==
===Abstract===
Aging is associated with sarcopenia. The loss of strength results in decreased muscle mass and motor function. This process accelerates the progressive muscle deterioration observed in older adults, favoring the presence of debilitating pathologies. In addition, sarcopenia leads to a decrease in quality of life, significantly affecting self-sufficiency. Altogether, these results in an increase in economic resources from the National Health Systems devoted to mitigating this problem in the elderly, particularly in developed countries. Different etiological determinants are involved in the progression of the disease, including: neurological factors, endocrine alterations, as well as nutritional and lifestyle changes related to the adoption of more sedentary habits. Molecular and cellular mechanisms have not been clearly characterized, resulting in the absence of an effective treatment for sarcopenia. Nevertheless, physical activity seems to be the sole strategy to delay sarcopenia and its symptoms. The present review intends to bring together the data explaining how physical activity modulates at a molecular and cellular level all factors that predispose or favor the progression of this deteriorating pathology.


===MeSH Terms===
|keywords=* aging
-
* laminarin
* neuroinflammation
* neuroprotection
* oxidative stress
* transient cerebral ischemia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230782
}}
{{medline-entry
|title=Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32294520


===Keywords===
aging; inflammation; oxidative stress; physical activity; sarcopenia; satellite cells


==Periodic training of creeping solids.==
|keywords=* Aging
===Abstract===
* CB1 receptor
We consider disordered solids in which the microscopic elements can deform plastically in response to stresses on them. We show that by driving the system periodically, this plasticity can be exploited to train in desired elastic properties, both in the global moduli and in local "allosteric" interactions. Periodic driving can couple an applied "source" strain to a "target" strain over a path in the energy landscape. This coupling allows control of the system's response, even at large strains well into the nonlinear regime, where it can be difficult to achieve control simply by design.
* Hippocampus
* Mitochondria
* Mitophagy
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.03.014
}}
{{medline-entry
|title=Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via [[CA1]]-Frontal Circuit.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239141


===MeSH Terms===
-


===Keywords===
|keywords=* aging
Poisson’s ratio; aging; allostery; plasticity
* functional connectivity
* hippocampus
* spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325802
}}
{{medline-entry
|title=Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219760


==Family matters in unraveling human longevity.==
===Abstract===
---


===MeSH Terms===
|keywords=* Acetylcholine
-
* Aging
* Brain
* Immunohistochemistry
* m1AChR
* qRT-PCR
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_23
}}
{{medline-entry
|title=Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32186114


===Keywords===
|mesh-terms=* Aging
aging; familial longevity; family; genes; longevity; social
* Animals
* Behavior, Animal
* CA1 Region, Hippocampal
* Catalase
* Dopamine
* Eclipta
* Galactose
* Gene Expression Regulation, Enzymologic
* Glutathione Peroxidase
* Glutathione Reductase
* Male
* Memory Disorders
* Nitric Oxide
* Nitric Oxide Synthase Type II
* Norepinephrine
* Plant Extracts
* RNA, Messenger
* Rats
* Rats, Sprague-Dawley
* Serotonin
* Spatial Learning
* Superoxide Dismutase
|keywords=* Antioxidants
* Eclipta
* Galactose
* Memory disorders
* Spatial learning


==Preparedness and response activities of the US Department of Veterans Affairs (VA) home-based primary care program around the fall 2017 hurricane season.==
}}
===Abstract===
{{medline-entry
Large-scale natural disasters disproportionally affect both the medically complex and the older old, groups that are responsible for most medical surge after a disaster. To understand how to ameliorate this surge, we examined the activities of the nine US Department of Veterans Affairs (VA) Home Based Primary Care (HBPC) programs impacted during the 2017 Fall Hurricane Season. Convergent mixed methods design, incorporating independently conducted qualitative and quantitative analyses. Phase One: 34 clinical staff were interviewed from the nine VA HBPC programs impacted by Hurricanes Harvey, Irma, and Maria to examine the experiences of their HBPC programs in response to the Hurricanes. Phase Two: Secondary quantitative data analysis used the VA's Corporate Data Warehouse (CDW) to examine the electronic health records of patients for these same nine sites. The emergency management activities of the HBPC programs emerged as two distinct phases: preparedness, and response and recovery. The early implementation of preparedness procedures, and coordinated post-Hurricane patient tracking, limited disruption in care and prevented significant hospitalizations among this population. Individuals aged 75 or older, who often present with multiple comorbidities and decreased functional status, typically prefer to age in their homes. Additionally, as in-home medical equipment evolves, more medically vulnerable individuals are able to receive care at home. HBPC programs, and similar programs under Medicare, connect the homebound, medically complex, older old to the greater healthcare community. Engaging with these programs both pre- and post-disasters is central to bolstering community resilience for these at-risk populations.
|title=Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107063


===MeSH Terms===
|mesh-terms=* Aged
-
* Aging
* Alzheimer Disease
* Atrophy
* Cohort Studies
* Cross-Sectional Studies
* Dentate Gyrus
* Female
* Hippocampus
* Humans
* Magnetic Resonance Imaging
* Male
* Neuropsychological Tests
* Risk
|keywords=* Aging
* Alzheimer's disease
* Hippocampal subfields
* MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.011
}}
{{medline-entry
|title=Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1  stem cells from young donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32028989


===Keywords===
|mesh-terms=* Animals
Aging in place; Emergency preparedness; Home health agencies; Long-term care
* Behavior, Animal
* Cognitive Dysfunction
* Dendritic Spines
* Hematopoietic Stem Cell Transplantation
* Hippocampus
* Humans
* Long-Term Potentiation
* Maze Learning
* Memory
* Mice
* Neurons
* Radiotherapy
* Recovery of Function
* Spinocerebellar Ataxias
* Treatment Outcome
|keywords=* Aging
* Bone marrow stem cells
* Learning and memory
* Microglia
* Radiotherapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006105
}}
{{medline-entry
|title=Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31919362


==Decreased testosterone secretion index and free testosterone level with multiple symptoms for late-onset hypogonadism identification: a nationwide multicenter study with 5980 aging males in China.==
|mesh-terms=* Aging
===Abstract===
* Animals
Late-onset hypogonadism (LOH) is a syndrome in middle-aged and elderly men caused by age-related testosterone deficiency. Age-related change of total testosterone (TT) of Asian males is different from Caucasian population, suggesting difference for LOH identification in Asians. A nationwide cross-sectional study involving six centers in China was conducted. Totally 6296 men aged 40-79 were recruited. After exclusions 5980 men were left for analyses. The serum TT level, was neither decreased with aging nor correlated with most hypogonadal symptoms. Instead, ten hypogonadal symptoms were found to be significantly correlated with free testosterone and testosterone secretion index, thus were chosen to form a concise scale. Further analysis identified a level of free testosterone <210 pmol/L, testosterone secretion index <1.8, and the concise scale score ≧17 could be diagnosed as having significantly aggravated LOH. This study developed an evidence-based criteria for LOH identification in Chinese population and may be adopted in other Asians. It includes the impaired testosterone secretion ability and deficiency of bioavailable testosterone, which should be the main cause in LOH pathogenesis despite normal TT levels, as well as correlated multiple hypogonadal symptoms. Our results may guide the LOH treatment to increase testicular function of testosterone secretion and bioavailable testosterone.
* Cyclin D1
* Cyclin-Dependent Kinase 4
* Female
* Hippocampus
* Learning
* Memory
* Memory Consolidation
* Mice
* Mice, Inbred C57BL
* Neural Stem Cells
* Neurogenesis


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952376
-
}}
{{medline-entry
|title=Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849620


===Keywords===
aging; aging male; late-onset hypogonadism; testosterone; testosterone secretion index


==Polarization-resolved SHG imaging as a fast screening method for collagen alterations during aging: Comparison with light and electron microscopy.==
|keywords=* aging
===Abstract===
* hippocampus
Our previous study on rat skin showed that cumulative oxidative pressure induces profound structural and ultrastructural alterations in both rat skin epidermis and dermis during aging. Here, we aimed to investigate the biophotonic properties of collagen as a main dermal component in the function of chronological aging. We used second harmonic generation (SHG) and two-photon excited fluorescence (TPEF) on 5 μm thick skin paraffin sections from 15-day-, 1-month- and 21-month-old rats, respectively, to analyze collagen alterations, in comparison to conventional light and electron microscopy methods. Obtained results show that polarization-resolved SHG (PSHG) images can detect collagen fiber alterations in line with chronological aging and that this method is consistent with light and electron microscopy. Moreover, the β coefficient calculated from PSHG images points out that delicate alterations lead to a more ordered structure of collagen molecules due to oxidative damage. The results of this study also open the possibility of successfully applying this fast and label-free method to previously fixed samples.
* memory
* mild cognitive impairment
* neuroimaging
* subfields
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897308
}}
{{medline-entry
|title=Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873156


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* CA3 Region, Hippocampal
* Long-Term Potentiation
* Mice
* Mossy Fibers, Hippocampal
* Spermidine
* Synaptic Transmission
* Synaptic Vesicles


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927957
chronological aging; collagen; electron microscopy; light microscopy; polarization-resolved SHG imaging; second-harmonic generation microscopy; two-photon excited fluorescence microscopy
}}
{{medline-entry
|title=Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843022


==Rest-Activity Rhythms and White Matter Microstructure Across the Lifespan.==
|mesh-terms=* Aging
===Abstract===
* Animals
The purpose of this study was to examine how rest-activity (RA) rhythm stability may be associated with white matter microstructure across the lifespan in healthy adults free of significant cardiovascular risk. We analyzed multi-shell diffusion tensor images from 103 healthy young and older adults using tract-based spatial statistics (TBSS) to examine relationships between white matter microstructure and RA rhythm stability. RA measures were computed using both cosinor and non-parametric methods derived from seven days of actigraphy data. Fractional anisotropy (FA) and mean diffusivity (MD) were examined in this analysis. Because prior studies have suggested that the corpus callosum (CC) is sensitive to sleep physiology and RA rhythms, we also conducted a focused region of interest analysis on the CC. Greater rest-activity rhythm stability was associated with greater FA across both young and older adults, primarily in the corpus callosum and anterior corona radiata. This effect was not moderated by age group. While RA measures were associated with sleep metrics, RA rhythm measures uniquely accounted for the variance in white matter integrity. This study strengthens existing evidence for a relationship between brain white matter structure and RA rhythm stability in the absence of health risk factors. While there are differences in RA stability between age groups, the relationship with brain white matter was present across both young and older adults. RA rhythms may be a useful biomarker of brain health across both periods of adult development.
* Caspase 6
* Caspase Inhibitors
* Cognitive Dysfunction
* Female
* Humans
* Inflammation
* Male
* Methylene Blue
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
|keywords=* Alzheimer disease
* Axonal degeneration
* Caspase-6
* Caspase-6 inhibitor
* Hippocampal CA1
* Hippocampal fibres
* Methylene blue
* Synaptic plasticity
* White matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915996
}}
{{medline-entry
|title=Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800021


===MeSH Terms===
-


===Keywords===
|keywords=* CA1 area
actigraphy; aging; circadian rhythms; neuroimaging; sleep and the brain
* CaMKII
* IntelliCages
* aging
* dendritic spines
* memory
* postsynaptic density
|full-text-url=https://sci-hub.do/10.1093/cercor/bhz261
}}
{{medline-entry
|title=PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769222


==A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.==
===Abstract===
Caloric restriction (CR) improves healthspan and lifespan of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging associated diseases. In budding yeast, [i]Saccharomyces cerevisiae[/i], CR is commonly defined by reduced glucose in the growth medium, which extends both replicative and chronological lifespan (CLS). We found that conditioned media collected from stationary phase CR cultures extended CLS when supplemented into non-restricted (NR) cultures, suggesting a potential cell non-autonomous mechanism of CR-induced lifespan regulation. Chromatography and untargeted metabolomics of the conditioned media, as well as transcriptional responses associated with the longevity effect, pointed to specific amino acids enriched in the CR conditioned media (CRCM) as functional molecules, with L-serine being a particularly strong candidate. Indeed, supplementing L-serine into NR cultures extended CLS through a mechanism dependent on the one-carbon metabolism pathway, thus implicating this conserved and central metabolic hub in lifespan regulation.


===MeSH Terms===
|keywords=* CA1
-
* CA3
* Fluoro-Jade C
* aging
* microglia
* radial arm maze
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955932
}}
{{medline-entry
|title=Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746286


===Keywords===
|mesh-terms=* Aging
Saccharomyces cerevisiae; aging; amino acid; caloric restriction; cell non-autonomous; chronological lifespan; one-carbon metabolism; serine
* Animals
* Male
* Mice
* Neuronal Plasticity
* Oxidative Stress
* Random Allocation
* Receptors, N-Methyl-D-Aspartate
* Testosterone
|keywords=* Alzheimer’s disease
* N-methyl-D-aspartate receptor-1
* Senescence accelerated mouse
* Testosterone
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/15287394.2019.1683988
}}
{{medline-entry
|title=Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31470103


==Frequent co-reactivation of Epstein-Barr virus in patients with cytomegalovirus viremia under immunosuppressive therapy and/or chemotherapy.==
|mesh-terms=* Aging
===Abstract===
* Animals
Co-reactivation of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) occurs in iatrogenically immunosuppressed patients, but the clinical relevance of this is unknown. We aimed to determine the frequency of EBV reactivation in patients with CMV viremia and to explore its clinical significance. Serum or plasma CMV and EBV DNA was detected by quantitative real-time PCR in 82 patients who received immunosuppressive therapy and/or chemotherapy and underwent CMV antigenemia tests. CMV DNA was positive in 55 patients, with EBV reactivation being found in 29 of these (52.7%). EBV co-reactivation was significantly associated with aging (>64 years vs. ≤64 years, odds ratio 4.07, 95% confidence interval 1.06-15.6). When older patients were divided into two groups according to age, EBV co-reactivation occurred more frequently in early-old patients (aged 65-74 years) than in late-old patients (aged ≥75 years) (100.0% vs. 53.3%, respectively). Steroid pulse treatment was administered significantly more often in the early-old group than in those aged ≤64 years and ≥75 years (72.7% vs 27.6% vs 14.3%, respectively). Co-reactivation of EBV in patients with CMV viremia highlighted early-old patients and may reflect treatment intensity as well as immunosenescence.
* Cholinergic Neurons
* Hippocampus
* Mice
* Mice, Inbred C57BL
* Physical Conditioning, Animal
* Presynaptic Terminals
* Spatial Memory
* Synaptophysin
|keywords=* Aging
* Cholinergic cells
* Hippocampus
* Memory
* Physical training
* Presynaptic terminals
* Synaptophysin
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104586
}}
{{medline-entry
|title=Senescent neurophysiology: Ca  signaling from the membrane to the nucleus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31394200


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* CA1 Region, Hippocampal
* Calcium Signaling
* Cell Nucleus
* Epigenesis, Genetic
* Excitatory Postsynaptic Potentials
* Humans
* Membrane Potentials
* Neuronal Plasticity
* Pyramidal Cells
* Receptors, N-Methyl-D-Aspartate
|keywords=* Afterhyperpolarization
* Aging
* Epigenetics
* Hippocampus
* N-methyl-D-aspartate receptor
* Synaptic plasticity
* Transcription
|full-text-url=https://sci-hub.do/10.1016/j.nlm.2019.107064
}}
==CA2==


===Keywords===
{{medline-entry
Cytomegalovirus; Epstein–Barr virus; chemotherapy; co-reactivation; immunosenescence; immunosuppression; older patients
|title=Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526748


==Cellular metabolism and IL-6 concentrations during stimulated inflammation in small and large dog breeds' primary fibroblasts cells, as they age.==
===Abstract===
The immune system undergoes marked changes during aging characterized by a state of chronic, low-grade inflammation, so called inflammaging. Domestic dogs are the most morphological and physiological diverse group of mammals, with the widest range in body masses for a single species. Additionally, smaller dogs tend to live significantly longer than larger dogs across all breeds. Body mass is intricately linked to mass-specific metabolism and aging rates, thus, dogs are exemplary for studies in inflammaging. Dermal fibroblasts cells play an important role in skin inflammation, and as such, are a good cell type to determine inflammatory patterns in dogs. Here, we examine aerobic and glycolytic cellular metabolism, and IL-6 concentrations in primary fibroblast cells isolated from small and large, young and old dogs when treated with lipopolysaccharide (LPS) from [i]Escherichia coli[/i] to stimulate an inflammatory phenotype. We found no differences in cellular metabolism of any group when treated with LPS. Unlike mice and humans, there was a less drastic amplification of IL-6 concentration after LPS treatment in the geriatric population of dogs compared with puppies. We also found evidence that large breed puppies have significantly less background or control IL-6 concentrations compared with small breed puppies. This implies that the patterns of inflammaging in dogs may be distinct and different from other mammals commonly studied.


===MeSH Terms===
|keywords=* Aging
-
* Behavior analysis
* Hippocampus
* Shaking exercise
* Spatial cognition
|full-text-url=https://sci-hub.do/10.1159/000507884
}}
{{medline-entry
|title=One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32008518


===Keywords===
|mesh-terms=* Aged
Body mass; Inflammaging; Lifespan
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Atrophy
* Case-Control Studies
* Cognitive Dysfunction
* Disease Progression
* Female
* Follow-Up Studies
* Hippocampus
* Humans
* Magnetic Resonance Imaging
* Male
* Neuroimaging
|keywords=* Alzheimer's disease
* biomarker
* hippocampal
* mild cognitive impairment
* neurodegenerative diseases
* normal aging
* radial distance
* subfield atrophy
|full-text-url=https://sci-hub.do/10.2174/1573405615666190327102052
}}
{{medline-entry
|title=Maturation of PNN and ErbB4 Signaling in Area [[CA2]] during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665627


==A Longitudinal Epigenetic Aging and Leukocyte Analysis of Simulated Space Travel: The Mars-500 Mission.==
|mesh-terms=* Aging
===Abstract===
* Animals
Astronauts undertaking long-duration space missions may be vulnerable to unique stressors that can impact human aging. Nevertheless, few studies have examined the relationship of mission duration with DNA-methylation-based biomarkers of aging in astronauts. Using data from the six participants of the Mars-500 mission, a high-fidelity 520-day ground simulation experiment, we tested relationships of mission duration with five longitudinally measured blood DNA-methylation-based metrics: DNAmGrimAge, DNAmPhenoAge, DNA-methylation-based estimator of telomere length (DNAmTL), mitotic divisions (epigenetic mitotic clock [epiTOC2]), and pace of aging (PoA). We provide evidence that, relative to baseline, mission duration was associated with significant decreases in epigenetic aging. However, only decreases in DNAmPhenoAge remained significant 7 days post-mission. We also observed significant changes in estimated proportions of plasmablasts, CD4T, CD8 naive, and natural killer (NK) cells. Only decreases in NK cells remained significant post-mission. If confirmed more broadly, these findings contribute insights to improve the understanding of the biological aging implications for individuals experiencing long-duration space travel.
* Animals, Newborn
* CA2 Region, Hippocampal
* Interneurons
* Long-Term Synaptic Depression
* Male
* Memory
* Mice
* Mice, Inbred C57BL
* Neural Inhibition
* Neuregulin-1
* Neuronal Plasticity
* Parvalbumins
* Receptor, ErbB-4
* Receptors, Opioid, delta
* Signal Transduction
* Social Behavior
* Synapses
* gamma-Aminobutyric Acid
|keywords=* ErbB4
* adolescence
* area CA2
* delta opioid receptors
* hippocampus
* long-term depression
* neuregulin 1
* parvalbumin interneuron
* perineuronal net
* social memory
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.09.044
}}
==CA3==


===MeSH Terms===
{{medline-entry
-
|title=Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581685


===Keywords===
DNA methylation age; Mars-500; aging; astronaut; epiTOC2; leukocytes; mitotic divisions; pace of aging; stress; telomere


==Association between SIRT6 Methylation and Human Longevity in a Chinese Population.==
|keywords=* Alzheimer’s disease
===Abstract===
* OXYS rats
Sirtuin 6 gene (SIRT6) is a longevity gene that is involved in a variety of metabolic pathways, but the relationship between SIRT6 methylation and longevity has not been clarified. We conducted a case-control study on 129 residents with a family history of longevity (1 of parents, themselves, or siblings aged ≥90 years) and 86 individuals without a family history of exceptional longevity to identify the association. DNA pyrosequencing was performed to analyze the methylation status of SIRT6 promoter CpG sites. qRT-PCR and ELISA were used to estimate the SIRT6 messenger RNA (mRNA) levels and protein content. Six CpG sites (P1-P6) were identified as methylation variable positions in the SIRT6 promoter region. At the P2 and P5 CpG sites, the methylation rates of the longevity group were lower than those of the control group (p < 0.001 and p = 0.009), which might be independent determinants of longevity. The mRNA and protein levels of SIRT6 decreased in the control group (p < 0.0001 and p = 0.038). The mRNA level negatively correlated with the methylation rates at the P2 (rs = -0.173, p = 0.011) and P5 sites (rs = -0.207, p = 0.002). Furthermore, the protein content positively correlated with the methylation rate at the P5 site (rs = 0.136, p = 0.046) but showed no significant correlation with the methylation rate at the P2 site. The low level of SIRT6 methylation may be a potential protective factor of Chinese longevity.
* aging
* hippocampal mossy fibers
* hippocampus
* neurogenesis
* postnatal development
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289999
}}
{{medline-entry
|title=Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332082


===MeSH Terms===
-


===Keywords===
|keywords=* aging
DNA Methylation; Longevity; Messenger RNA; SIRT6
* conditional transgenic
* giant synapse
* stratum lucidum
* synaptogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240290
}}
{{medline-entry
|title=Metabotropic Glutamate Receptors at the Aged Mossy Fiber - [[CA3]] Synapse of the Hippocampus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917351


==Aging effects on fractionation and speciation of redox-sensitive metals in artificially contaminated soil.==
===Abstract===
Artificially contaminated soil is often used in laboratory experiments as a substitute for actual field contaminated soils. In the preparation and use of laboratory contaminated soils, questions remain as to how much and how long metals remain in labile form and in their oxidation state during the contamination process. Therefore, the objectives of this study were to determine if the speciation of added contaminants can be retained in the original form and to observe the change in lability of each element with aging time. In this study, natural soil was artificially polluted with five redox-sensitive toxic elements in their oxidized or reduced forms, i.e., As(III)/As(V), Sb(III)/Sb(V), Cr(III)/Cr(VI), Mo(VI), and W(V). Metal distribution was measured in progressive chemical fractionation using sequential extraction methods in contaminated soils after 3, 100, and 300 days of aging. The results indicated that the more strongly bound fraction of metals increased by day 100; whereas the fractions were not significantly different from those in the 300-day-aged soil. Among five metals, the ratio of weakly-bound fractions remained highest in As- and lowest in Cr-contaminated soils. The W(VI)-contaminated soil showed strong sorption without changes in speciation during aging. The oxidized or reduced metal species converged to occur as a single species under given soil conditions, regardless of the initial form of metal used to spike the soil. Both As and Sb existed as their oxidized form while Cr existed as its reduced form. The results of this study may provide a useful and practical guideline for artificial soil contamination.


===MeSH Terms===
|keywords=* aging
-
* hippocampal area CA3
* mGluRs
* mossy fibers
* synaptic transmission
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2019.12.016
}}
==CACNA1S==


===Keywords===
{{medline-entry
Redox-sensitive metals; Sequential extraction; Soil aging; Speciation; X-ray absorption spectroscopy
|title=Increased calcium channel in the lamina propria of aging rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31682233


==Twelve-Week Daily Consumption of [i]ad hoc[/i] Fortified Milk with ω-3, D, and Group B Vitamins Has a Positive Impact on Inflammaging Parameters: A Randomized Cross-Over Trial.==
|mesh-terms=* Aging
===Abstract===
* Animals
A state of chronic, subclinical inflammation known as inflammaging is present in elderly people and represents a risk factor for all age-related diseases. Dietary supplementation with [i]ad hoc[/i] fortified foods seems an appealing strategy to counteract inflammaging. The purpose of this study was to test the efficacy of elderly-tailored fortified milk on inflammaging and different health parameters. A double-blind randomized cross-over study was performed on forty-eight volunteers aged 63-80 years. The fortified milk was enriched with ω-3 polyunsaturated fatty acids (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA), vitamins (25-hydroxyvitamin D, E, C, B6, B9, B12), and trace elements (zinc, selenium). The two intervention periods lasted for 12 weeks, with a 16-week washout intermission. Compared to placebo, the consumption of fortified milk increased the circulating levels of different micronutrients, including vitamins and the ω-3 index of erythrocyte membranes. Conversely, it reduced the amount of arachidonic acid, homocysteine, and ω-6/ω-3 ratio. Twelve-week daily consumption of [i]ad[/i][i]hoc[/i] fortified milk has an overall positive impact on different health parameters related to inflammaging in the elderly.
* Calcium Channel Blockers
* Calcium Channels
* Cell Line
* Fibroblasts
* Gene Expression Regulation
* Humans
* Larynx
* Male
* Mucous Membrane
* Rats
* Rats, Sprague-Dawley
* Verapamil
|keywords=* aging
* calcium channel
* extracellular matrix
* vocal fold
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834399
}}
==CAD==


===MeSH Terms===
{{medline-entry
-
|title=Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33303310


===Keywords===
aging; fortified milk; homocysteine; ω-3 index; ω-6/ω-3 ratio


==ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.==
|keywords=* Aging
===Abstract===
* Coronary artery calcification
Aging increases risk for ischemic vascular diseases. Bone marrow-derived hematopoietic stem/progenitor cells (HSPCs) are known to stimulate vascular regeneration. Activation of either the Mas receptor (MasR) by angiotensin-(1-7) (Ang-(1-7)) or angiotensin-converting enzyme-2 (ACE2) stimulates vasoreparative functions in HSPCs. This study tested if aging is associated with decreased ACE2 expression in HSPCs and if Ang-(1-7) restores vasoreparative functions. Flow cytometric enumeration of Lin CD45 CD34  cells was carried out in peripheral blood of male or female individuals (22-83 years of age). Activity of ACE2 or the classical angiotensin-converting enzyme (ACE) was determined in lysates of HSPCs. Lin Sca-1 cKit  (LSK) cells were isolated from young (3-5 months) or old (20-22 months) mice, and migration and proliferation were evaluated. Old mice were treated with Ang-(1-7), and mobilization of HSPCs was determined following ischemia induced by femoral ligation. A laser Doppler blood flow meter was used to determine blood flow. Aging was associated with decreased number (Spearman r = - 0.598, P < 0.0001, n = 56), decreased ACE2 (r = - 0.677, P < 0.0004), and increased ACE activity (r = 0.872, P < 0.0001) (n = 23) in HSPCs. Migration or proliferation of LSK cells in basal or in response to stromal-derived factor-1α in old cells is attenuated compared to young, and these dysfunctions were reversed by Ang-(1-7). Ischemia increased the number of circulating LSK cells in young mice, and blood flow to ischemic areas was recovered. These responses were impaired in old mice but were restored by treatment with Ang-(1-7). These results suggest that activation of ACE2 or MasR would be a promising approach for enhancing ischemic vascular repair in aging.
* Intravascular ultrasound
* Klotho
|full-text-url=https://sci-hub.do/10.1016/j.jjcc.2020.11.014
}}
{{medline-entry
|title=Shear bond strengths of aged and non-aged [[CAD]]/CAM materials after different surface treatments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149848


===MeSH Terms===
-


===Keywords===
|keywords=* Bond strength
ACE2; Aging; Angiotensin-(1-7); Hematopoietic stem/progenitor cells; Ischemia
* Computer-aided design and computer-aided manufacturing (CAD/CAM)
* Laser
* Repair
* Surface treatment
* Thermal aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604239
}}
{{medline-entry
|title=Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546993


==Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.==
|mesh-terms=* Aged
===Abstract===
* Aortic Valve Stenosis
Cellular senescence is defined as a stable, persistent arrest of cell proliferation. Here, we examine whether senescent cells can lose senescence hallmarks and reenter a reversible state of cell-cycle arrest (quiescence). We constructed a molecular regulatory network of cellular senescence based on previous experimental evidence. To infer the regulatory logic of the network, we performed phosphoprotein array experiments with normal human dermal fibroblasts and used the data to optimize the regulatory relationships between molecules with an evolutionary algorithm. From ensemble analysis of network models, we identified 3-phosphoinositide-dependent protein kinase 1 (PDK1) as a promising target for inhibitors to convert the senescent state to the quiescent state. We showed that inhibition of PDK1 in senescent human dermal fibroblasts eradicates senescence hallmarks and restores entry into the cell cycle by suppressing both nuclear factor κB and mTOR signaling, resulting in restored skin regeneration capacity. Our findings provide insight into a potential therapeutic strategy to treat age-related diseases associated with the accumulation of senescent cells.
* Cardiovascular Diseases
* Comorbidity
* Echocardiography
* Female
* Fracture Fixation
* Hip Fractures
* Hospital Mortality
* Humans
* Male
* Postoperative Complications
* Prognosis
* Risk Factors
|keywords=* aging
* echocardiographic abnormality
* hip fracture surgery
* mortality
* postoperative cardiac complications
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266334
}}
{{medline-entry
|title=[Polymorbidity in elderly patients needing myocardial revascularization (a review article).]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800187


===MeSH Terms===
|mesh-terms=* Aged
-
* Cognitive Dysfunction
* Coronary Artery Disease
* Humans
* Myocardial Revascularization
* Quality of Life
* Risk
|keywords=* aging
* elderly
* ischemic heart disease
* myocardial revascularization
* polymorbidity


===Keywords===
}}
PDK1; cellular senescence; network modeling; skin aging; systems biology
{{medline-entry
|title=Fracture force of [[CAD]]/CAM resin composite crowns after in vitro aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712983


==Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle.==
|mesh-terms=* Ceramics
===Abstract===
* Composite Resins
Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for two weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI + nuclei in aged muscle in response to MTE. LM-111 reduced CD11b + immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.
* Computer-Aided Design
* Crowns
* Dental Porcelain
* Dental Restoration Failure
* Dental Stress Analysis
* Humans
* Materials Testing
|keywords=* Aging
* CAD/CAM
* CAD/CAM bloc
* Dental material
* Fit
* Preparation
* Resin composite
* Resin-based material
* Storage
* TCML
|full-text-url=https://sci-hub.do/10.1007/s00784-019-03099-1
}}
{{medline-entry
|title=Clinical performance of chairside monolithic lithium disilicate glass-ceramic [[CAD]]-CAM crowns.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565848


===MeSH Terms===
|mesh-terms=* Ceramics
-
* Computer-Aided Design
* Crowns
* Dental Porcelain
* Dental Prosthesis Design
* Humans
* Materials Testing
|keywords=* CAD-CAM
* chairside
* dental crowns
* lithium disilicate
* longevity
* survival
|full-text-url=https://sci-hub.do/10.1111/jerd.12531
}}
{{medline-entry
|title=Acute resveratrol supplementation in coronary artery disease: towards patient stratification.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31429599


===Keywords===
|mesh-terms=* Aged
aging; chronic mechanical loading; extracellular matrix; hypertrophy; integrin
* Biomarkers
* Brachial Artery
* Cardiac Rehabilitation
* Coronary Artery Bypass
* Coronary Artery Disease
* Cross-Over Studies
* Exercise Therapy
* Female
* Humans
* Kinetics
* Male
* Middle Aged
* Oxygen
* Oxygen Consumption
* Percutaneous Coronary Intervention
* Resveratrol
* Single-Blind Method
* Treatment Outcome
* Vasodilation
|keywords=* Antioxidant
* aging
* endothelial dysfunction
* oxygen uptake
|full-text-url=https://sci-hub.do/10.1080/14017431.2019.1657584
}}
==CARM1==


==Attitudes of Polish Seniors toward the Use of Public Space during the First Wave of the COVID-19 Pandemic.==
{{medline-entry
===Abstract===
|title=[[CARM1]] regulates senescence during airway epithelial cell injury in COPD pathogenesis.
The number of seniors rises worldwide. The lockdown of public institutions caused by COVID-19 influenced the lives of many of them. In the new reality, owners and managers of public spaces need to rethink the way they provide their services, and redesign public spaces to meet the needs of senior citizens. This requires the recognition of the needs of seniors concerning the use of public spaces in the times of the COVID-19 hazard. To investigate this issue, survey studies with 1000 respondents aged 65+ were conducted. The implementation of the obtained data in the process of redesigning public spaces may facilitate the opening up after the lockdown. Taking into account the requirements of a very large group of citizens being seniors is crucial, as it was found that 55% of respondents will also be afraid to use public spaces after the COVID-19 lockdown. The selected ideas that could minimize the feeling of fear when using public spaces after the lockdown were evaluated by seniors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31461302


===MeSH Terms===
|mesh-terms=* Aged
-
* Animals
* Apoptosis
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* Epithelial Cells
* Female
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Naphthalenes
* Protein-Arginine N-Methyltransferases
* Pulmonary Disease, Chronic Obstructive
* Respiratory Mucosa
* Wound Healing
|keywords=* CARM1
* COPD
* airway epithelium
* senescence
|full-text-url=https://sci-hub.do/10.1152/ajplung.00441.2018
}}
==CASP3==


===Keywords===
{{medline-entry
aging population; coronavirus; design; furniture; lockdown; public areas
|title=Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31502578


==Aging of Brain Related with Mitochondrial Dysfunctions.==
|mesh-terms=* Aging
===Abstract===
* Animals
Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity, regulates vital physiological events; however, the susceptibility of the brain to aging-related disturbances signal the onset of neurodegenerative diseases. Mitochondrial dysfunctions impair bioenergetic mechanism, synaptic plasticity, and calcium homeostasis in the brain, thus sufficiently implying mitochondria as a prime causal factor in accelerating aging-related neurodegeneration. We reviewed the fundamental functions of mitochondria in a healthy brain and aimed to address the key issues in aging-related diseases by asking: 1) What goes wrong with mitochondria in the aging brain? 2) What are the implications of mitochondrial damage on motor functions and psychiatric symptoms? 3) How environmental chemicals and metabolic morbidities affect mitochondrial functions? Further, we share insight on opportunities and pitfalls in drug discovery approaches targeting mitochondria to slow down the progression of aging and related neurodegenerative diseases.
* Bone Development
* Cartilage
* Chondrocytes
* Diclofenac
* Disease Models, Animal
* Estrogen Receptor alpha
* Flavonoids
* Gallic Acid
* Gene Expression Regulation
* Humans
* Iodoacetates
* Matrix Metalloproteinase 13
* Metabolism
* Osteoarthritis
* Ovariectomy
* Plant Extracts
* Primulaceae
* Rats


===MeSH Terms===
-


===Keywords===
}}
Aging; Mitochondria; Synaptic plasticity; biomarkers; membrane permeability; metabolic morbidity; neuropsychiatric symptoms
==CAT==


==Prediction of resting energy expenditure in healthy older adults: A systematic review.==
{{medline-entry
===Abstract===
|title=Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease.
Estimates of energy requirements, based on measured or predicted resting energy expenditure (REE), are needed to avoid undernutrition or overnutrition (and their clinical consequences) in elderly subjects. The aims of this systematic review were to evaluate the prediction accuracy of REE in healthy elderly subjects and to ascertain which equation is more reliable at group level and/or individual level. Studies assessing prediction of REE in general elderly population were systematically searched using PubMed, EMBASE, Web of Science and CINAHL until March 2020. Prediction accuracy of REE was assessed at both group (bias) and individual (precision) level for each equation. Fourteen studies met the inclusion criteria of this systematic review. Bias was reported in 8 papers and calculated in another 5 from absolute values. There was a prevalent tendency towards an overestimation of REE across the studies. The least bias was observed for the Mifflin (-0.3%) and Harris-Benedict (+2.6%) equations, with values above 5% for the FAO/WHO/UNU, Fredrix and Muller equations. Precision widely varied between studies for the same equation. The higher precision was observed using the Harris-Benedict equation (~70%), while the Henry and Mifflin equations provided estimates within 10% of measured values in 65% and 61% of elderly individuals, respectively. None of the prediction equations considered provides accurate and precise REE estimates in healthy older adults. However, the best prediction is given by the Mifflin equation at group level and by the Harris-Benedict equation at individual level. Further studies with strong quality design are needed to evaluate the variability and accuracy of REE in the elderly general population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33036566


===MeSH Terms===
-


===Keywords===
|keywords=* Chronic-obstructive pulmonary disease - Inhaler devices
Aging; Energy requirements; Indirect calorimetry; Resting metabolic rate
* Compliance
* Geriatrics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547456
}}
{{medline-entry
|title=7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32931926


==Glycation-mediated protein crosslinking and stiffening in mouse lenses are inhibited by carboxitin in vitro.==
===Abstract===
Proteins in the eye lens have negligible turnover and therefore progressively accumulate chemical modifications during aging. Carbonyls and oxidative stresses, which are intricately linked to one another, predominantly drive such modifications. Oxidative stress leads to the loss of glutathione (GSH) and ascorbate degradation; this in turn leads to the formation of highly reactive dicarbonyl compounds that react with proteins to form advanced glycation end products (AGEs). The formation of AGEs leads to the crosslinking and aggregation of proteins contributing to lens aging and cataract formation. To inhibit AGE formation, we developed a disulfide compound linking GSH diester and mercaptoethylguanidine, and we named it carboxitin. Bovine lens organ cultured with carboxitin showed higher levels of GSH and mercaptoethylguanidine in the lens nucleus. Carboxitin inhibited erythrulose-mediated mouse lens protein crosslinking, AGE formation and the formation of 3-deoxythreosone, a major ascorbate-derived AGE precursor in the human lens. Carboxitin inhibited the glycation-mediated increase in stiffness in organ-cultured mouse lenses measured using compressive mechanical strain. Delivery of carboxitin into the lens increases GSH levels, traps dicarbonyl compounds and inhibits AGE formation. These properties of carboxitin could be exploited to develop a therapy against the formation of AGEs and the increase in stiffness that causes presbyopia in aging lenses.


===MeSH Terms===
|keywords=* 4-PSQ
-
* 7-chloro-4-(phenylselanyl) quinolone
* Antioxidant effect
* Diabetic-like phenotype
* Hyperglycidic diet
* Longevity
* Oxidative stress
|full-text-url=https://sci-hub.do/10.1016/j.cbpc.2020.108892
}}
{{medline-entry
|title=Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32827711


===Keywords===
Aging; Carboxitin; Glycation; Lens; Mass spectrometry; Presbyopia; Protein crosslinking


==Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study.==
|keywords=* Aging
===Abstract===
* Blood-brain barrier
Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate-severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. Moderate-severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate-severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults.
* Brain
* Oxidative stress
* Sepsis
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111063
}}
{{medline-entry
|title=2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559563


===MeSH Terms===
-


===Keywords===
|keywords=* 2-Deoxy- d-glucose
Aging; Cardiovascular; Multimorbidity; Musculoskeletal; Neuropsychiatric; Sleep disturbances
* Aging
* Brain
* CRM
* Mitohormosis
* ROS
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104133
}}
{{medline-entry
|title=Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32440324


==Anterolateral entorhinal cortex volume is associated with memory retention in clinically unimpaired older adults.==
===Abstract===
The entorhinal cortex is subdivided into anterolateral entorhinal cortex (alERC) and posteromedial entorhinal cortex (pmERC) subregions, which are theorized to support distinct cognitive roles. This distinction is particularly important as the alERC is one of the earliest cortical regions affected by Alzheimer's pathology and related neurodegeneration. The relative associations of alERC/pmERC with neuropsychological test performance have not been examined. We examined how alERC/pmERC volumes differentially relate to performance on 1) the Modified Rey Auditory Learning Test (ModRey), a verbal memory test designed to assess normal/preclinical populations, 2) the Montreal Cognitive Assessment (MoCA), and 3) the National Alzheimer's Coordinating Center neuropsychological battery. We also examined whether alERC/pmERC volumes correlate with Alzheimer's disease cerebrospinal fluid (CSF) biomarkers. In 65 cognitively healthy (CDR = 0) older adults, alERC, but not pmERC, volume was associated with ModRey memory retention. Only alERC volume differentiated between participants who scored above and below the MoCA cutoff score for impairment. Evaluating the MoCA subdomains revealed that alERC was particularly associated with verbal recall. On the National Alzheimer's Coordinating Center battery, both alERC and pmERC volumes were associated with Craft story recall and Benson figure copy, but only alERC volume was associated with Craft story retention and semantic fluency. Neither alERC nor pmERC volume correlated with CSF levels of amyloid or tau, and regression analyses showed that alERC volume and CSF amyloid levels were independently associated with ModRey retention performance. Taken together, these results suggest that the alERC is important for memory performance and that alERC volume differences are related to a pattern of neuropsychological test performance (i.e., impairments in episodic memory and semantic fluency) typically seen in clinical Alzheimer's disease.


===MeSH Terms===
|keywords=* Aging
-
* Ceftriaxone
* D-galactose
* Mice
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229512
}}
{{medline-entry
|title=Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32437790


===Keywords===
|mesh-terms=* Animals
Aging; Amyloid; Entorhinal cortex; Memory; Neuropsychology
* Antioxidants
* Cellular Senescence
* Disease Models, Animal
* Fatty Liver
* Forkhead Box Protein O1
* Galactose
* Ginsenosides
* Lipid Peroxidation
* Male
* Medicine, Chinese Traditional
* Mice
* Mice, Inbred C57BL
* Oxidative Stress
* Protective Agents
* Transcription Factors
|keywords=* D-galactose
* FOXO1
* Non-alcoholic fatty liver disease
* Rg1
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117776
}}
{{medline-entry
|title=Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424629


==Adaptive response of resistant cancer cells to chemotherapy.==
|mesh-terms=* Aging
===Abstract===
* Animals
Despite advances in cancer therapeutics and the integration of personalized medicine, the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality. Upon treatment with chemotherapeutics, the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism. In this review, we summarize the mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy. We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms, with the goal of stimulating research that may facilitate the development of effective cancer therapy.
* Antioxidants
* Caloric Restriction
* Catalase
* Erythrocytes
* Female
* Glutathione
* Lipid Peroxidation
* Malondialdehyde
* Mammary Neoplasms, Experimental
* Mice, Inbred C57BL
* Oxidative Stress
* Superoxide Dismutase
|keywords=* MMTV-TGF-α mice
* breast cancer
* energy restriction
* intermittent calorie restriction
* mammary tumor
* oxidative stress
|full-text-url=https://sci-hub.do/10.1002/iub.2145
}}
{{medline-entry
|title=The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31403715


===MeSH Terms===
|mesh-terms=* Aquatic Organisms
-
* Chlorophyta
* Fresh Water
* Hydrodynamics
* Lipid Peroxidation
* Metal Nanoparticles
* Particle Size
* Reactive Oxygen Species
* Silver
* Static Electricity
* Toxicity Tests
|keywords=* Aquatic toxicology
* Ecotoxicology
* Environmental fate
* Heavy metals
* Nanoparticle aging
* Nanotoxicology
|full-text-url=https://sci-hub.do/10.1002/etc.4549
}}
==CBS==


===Keywords===
{{medline-entry
Cancer; ER stress signaling; adaptive response; autophagy; chemoresistance; chemotherapy; senescence
|title=Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32800520


==Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries.==
===Abstract===
Transglutaminase 2 (TG2) is an enzyme which in the open conformation exerts transamidase activity, leading to protein cross-linking and fibrosis. In the closed conformation, TG2 participates in transmembrane signaling as a G protein. The unspecific transglutaminase inhibitor cystamine causes vasorelaxation in rat resistance arteries. However, the role of TG2 conformation in vascular function is unknown. We investigated the vascular effects of selective TG2 inhibitors by myography in isolated rat mesenteric and human subcutaneous resistance arteries, patch-clamp studies on vascular smooth muscle cells, and blood pressure measurements in rats and mice. LDN 27219 promoted the closed TG2 conformation and inhibited transamidase activity in mesenteric arteries. In contrast to TG2 inhibitors promoting the open conformation (Z-DON, VA5), LDN 27219 concentration-dependently relaxed rat and resistance human arteries by a mechanism dependent on nitric oxide, large-conductance calcium-activated and voltage-gated potassium channels 7, lowering blood pressure. LDN 27219 also potentiated acetylcholine-induced relaxation by opening potassium channels in the smooth muscle; these effects were abolished by membrane-permeable TG2 inhibitors promoting the open conformation. In isolated arteries from 35- to 40-week-old rats, transamidase activity was increased, and LDN 27219 improved acetylcholine-induced relaxation more than in younger rats. Infusion of LDN 27219 decreased blood pressure more effectively in 35- to 40-week than 12- to 14-week-old anesthetized rats. In summary, pharmacological modulation of TG2 to the closed conformation age-dependently lowers blood pressure and, by opening potassium channels, potentiates endothelium-dependent vasorelaxation. Our findings suggest that promoting the closed conformation of TG2 is a potential strategy to treat age-related vascular dysfunction and lowers blood pressure.


===MeSH Terms===
|keywords=* Cellular senescence
-
* Cystathionine β-synthase
* Human adipose-derived mesenchymal stem cells
* Inflammation
* Oxidative stress and adipogenesis
|full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101668
}}
{{medline-entry
|title=Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32027885


===Keywords===
|mesh-terms=* Animals
aging; blood pressure; fibrosis; nitric oxide; potassium channels
* Antioxidants
* Cardiovascular System
* Cystathionine beta-Synthase
* Cystathionine gamma-Lyase
* Gene Expression Regulation, Enzymologic
* Hydrogen Sulfide
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Myocardial Reperfusion Injury
* Myocytes, Cardiac
* Nitric Oxide
* Phenotype
* Reactive Oxygen Species
* Sulfurtransferases
* Vasodilation
|keywords=* 3-mercaptopyruvate transferase (3-MST)
* Aging
* Blood pressure
* Myocardial infarction
* Nitric Oxide (NO)
* Reactive Oxygen Species (ROS)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657663
}}
==CBX3==


==Thymus involution sets the clock of declined immunity and repair with aging.==
{{medline-entry
===Abstract===
|title=Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.
Aging is generally characterized as a gradual increase in tissue damage, which is associated with senescence and chronic systemic inflammation and is evident in a variety of age-related diseases. The extent to which such tissue damage is a result of a gradual decline in immune regulation, which consequently compromises the capacity of the body to repair damages, has not been fully explored. Whereas CD4 T lymphocytes play a critical role in the orchestration of immunity, thymus involution initiates gradual changes in the CD4 T-cell landscape, which may significantly compromise tissue repair. In this review, we describe the lifespan accumulation of specific dysregulated CD4 T-cell subsets and their coevolution with systemic inflammation in the process of declined immunity and tissue repair capacity with age. Then, we discuss the process of thymus involution-which appears to be most pronounced around puberty-as a possible driver of the aging T-cell landscape. Finally, we identify individualized T cell-based early diagnostic biomarkers and therapeutic strategies for age-related diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979540


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Aging; Chronic systemic inflammation; Dysregulated CD4 T cells; Immune-mediated repair; Thymus
* Bone
* CBX1
* CBX2
* CBX3
* CBX4
* CBX5
* CBX6
* CBX7
* CBX8
* Cancer
* Chromatin
* Development
* Epigenetics
* H3K27me3
* H3K9me3
* Lineage-commitment
* Osteoblast
* Senescence
* Stem cell
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115659
}}
==CCK==


==A meta-analysis of heavy metal bioavailability response to biochar aging: Importance of soil and biochar properties.==
{{medline-entry
===Abstract===
|title=Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
Biochar has been widely applied to remediate the heavy metal-polluted soils, whereas biochar aging can induce the changes of the biochar physic-chemical properties. Afterwards, the bioavailability of heavy metals (BHM) will vary in soils which likely increase the unstable fractions of heavy metals and the following environmental risks. To explore the biochar aging effects on the BHM changes in responses to the variation of experimental conditions and biochar properties, a meta-analysis for the literatures published before May 2020 was conducted. A sum of 257 independent observations from 22 published papers was obtained. The results from the analysis of boosted regression tree showed that the soil pH was the most important factor influencing the BHM changes in biochar amended soil, followed by soil texture, aging time and biochar pyrolysis temperature. The results of this review showed that the BHM was decreased by 16.9%, 28.7% and 6.4% in weakly acid soil (pH 6.00-6.99), coarse- and medium-textured soils, respectively, but increased by 149% and 121% in the alkaline (pH > 8.00) and fine-textured soils. The BHM declined in the soils amended with biochar pyrolyzed at relative high temperature (> 500 °C), and increased during aging in soils amended with biochar pyrolyzed at relatively low temperature (401-500 °C). In terms of diverse immobilized heavy metals, only bioavailable Zn in soil decreased after aging. However, there was no significant changes in Cd, Cu and Pb's bioavalability. Besides, the BHM was decreased by 18.6% within the short-term (less than one year) biochar aging, while showed inverse trend during the longer aging processes. Besides, the application of lignin-enriched biochar may counteract the positive effects of the biochar aging on BHM. Our works may promote the interpretation of the interference factors on the BHM changes and filled the research gaps on biochar aging process in soils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33242601


===MeSH Terms===
-


===Keywords===
|keywords=* Intervertebral disc degeneration
Bioavailability; Biochar aging; Heavy metal; Immobilization; Meta-analysis
* NF-κB pathway
* Nrf2
* Quercetin
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.joca.2020.11.006
}}
{{medline-entry
|title=Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32355520


==Lower Cardiac Output Relates to Longitudinal Cognitive Decline in Aging Adults.==
===Abstract===
Subclinical reductions in cardiac output correspond to lower cerebral blood flow (CBF), placing the brain at risk for functional changes. This study aims to establish the consequences of reduced cardiac output on longitudinal cognitive outcomes in aging adults. Vanderbilt Memory and Aging Project participants free of clinical dementia and heart failure ([i]n[/i] = 306, 73 ± 7, 58% male) underwent baseline echocardiography to assess cardiac output (L/min) and longitudinal neuropsychological assessment at baseline, 18 months, 3 and 5 years. Linear mixed-effects regressions related cardiac output to trajectory for each longitudinal neuropsychological outcome, adjusting for age, sex, race/ethnicity, education, body surface area, Framingham Stroke Risk Profile score, apolipoprotein E ([i]APOE[/i]) ε4 status and follow-up time. Models were repeated, testing interactions with cognitive diagnosis and [i]APOE-[/i]ε4 status. Lower baseline cardiac output related to faster declines in language (β = 0.11, [i]p[/i] = 0.01), information processing speed (β = 0.31, [i]p[/i] = 0.006), visuospatial skills (β = 0.09, [i]p[/i] = 0.03), and episodic memory (β = 0.02, [i]p[/i] = 0.001). No [i]cardiac output x cognitive diagnosis[/i] interactions were observed ([i]p[/i] > 0.26). [i]APOE[/i]-ε4 status modified the association between cardiac output and longitudinal episodic memory (β = 0.03, [i]p[/i] = 0.047) and information processing speed outcomes (β = 0.55, [i]p[/i] = 0.02) with associations stronger in [i]APOE-[/i]ε4 carriers. The present study provides evidence that even subtle reductions in cardiac output may be associated with more adverse longitudinal cognitive health, including worse language, information processing speed, visuospatial skills, and episodic memory performances. Preservation of healthy cardiac functioning is important for maintaining optimal brain aging among older adults.


===MeSH Terms===
|keywords=* Astragalus
-
* BMSCs
* VD-FGF23-Klotho axis
* aging
* osteogenesis differentiation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191145
}}
{{medline-entry
|title=Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268554


===Keywords===
aging; apolipoprotein E ε4; cardiac function; cognitive decline; mild cognitive impairment


==Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions.==
|keywords=* aging
===Abstract===
* appetite
Shortened telomeres are associated with aging and age-related diseases. Oxidative stress is thought to be a major contributor to telomere shortening, and antioxidants may be able to mitigate these effects. Ergothioneine is a naturally occurring amino acid with potent antioxidant properties. In order to investigate ergothioneine's effects on telomere length, we cultured primary human fibroblasts under standard and oxidative (10 µM H O ) conditions and treated cells with 0.04, 0.1, 0.3, or 1.0 mg/ml ergothioneine for 8 weeks. Telomere length measurements were performed using high-throughput quantitative fluorescent in situ hybridization (HT Q-FISH). Treatment with ergothioneine transiently increased relative telomerase activity after 24 h ([i]p[/i] < 0.05 for all concentrations). Under oxidative conditions, ergothioneine treatment resulted in significantly longer median telomere length and 20  percentile telomere length, and significantly reduced the percentage of short telomeres (<3 kilobase pairs) for all treatment concentrations after 8 weeks. Telomere shortening rate was also reduced. Overall, ergothioneine demonstrated beneficial effects by decreasing the rate of telomere shortening and preserving telomere length under oxidative stress conditions. Our data support a potential role for ergothioneine in oxidative stress-related conditions and healthy aging.
* energy intake
* gastric emptying
* glucose
* gut hormones
* whey protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231005
}}
{{medline-entry
|title=Lactose induced redox-dependent senescence and activated Nrf2 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31934025


===MeSH Terms===
-


===Keywords===
|keywords=* Lactose
aging; antioxidants; ergothioneine; telomerase; telomeres
* Nrf2
* ROS
* cellular senescence
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949649
}}
{{medline-entry
|title=Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816893


==Discovery of 4H-chromeno[2,3-d]pyrimidin-4-one derivatives as senescence inducers and their senescence-associated antiproliferative activities on cancer cells using advanced phenotypic assay.==
|mesh-terms=* Adenine
===Abstract===
* Animals
Current research suggests therapy-induced senescence (TIS) of cancer cells characterized by distinct morphological and biochemical phenotypic changes represent a novel functional target that may enhance the effectiveness of cancer therapy. In order to identify novel small-molecule inducers of cellular senescence and determine the potential to be used for the treatment of melanoma, a new method of high-throughput screening (HTS) and high-contents screening (HCS) based on the detection of morphological changes was designed. This image-based and whole cell-based technology was applied to screen and select a novel class of antiproliferative agents on cancer cells, 4H-chromeno[2,3-d]pyrimidin-4-one derivatives, which induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. To evaluate structure-activity relationship (SAR) study of 4H-chromeno[2,3-d]pyrimidin-4-one scaffold starting from hit 3, a focused library containing diversely modified analogues was constructed and which led to the identification of 38, a novel compound to have remarkable anti-melanoma activity in vitro with good metabolic stability.
* Atherosclerosis
* Autophagy
* Cell Survival
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Cyclin-Dependent Kinase Inhibitor p21
* Disease Progression
* Foam Cells
* Hepatocyte Growth Factor
* Lipid Metabolism
* Lipoproteins, LDL
* Mice
* Proto-Oncogene Proteins
* Quercetin
* RAW 264.7 Cells
* Sirolimus
* Up-Regulation
|keywords=* RAW264.7
* atherosclerosis
* autophagy
* quercetin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928812
}}
{{medline-entry
|title=LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781342


===MeSH Terms===
|mesh-terms=* Adenosine Triphosphate
-
* Aging
* Animals
* Cell Survival
* DNA-Binding Proteins
* Gene Silencing
* Hair Cells, Auditory
* Hearing Loss
* Mice
* Mitochondria
* Organelle Biogenesis
* RNA, Long Noncoding
* Resveratrol
* Signal Transduction
* Transcription Factors


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855056
Antiproliferative agents; High-contents screening; High-throughput screening; Melanoma; Senescence; Structure-activity relationship
}}
{{medline-entry
|title=Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31705967


==Age and education as factors associated with medication literacy: a community pharmacy perspective.==
===Abstract===
Aging implies a higher prevalence of chronic pathologies and a corresponding increase in medication. The correct adherence and use of the medication are prerequisites for reducing risks of disease progression, comorbidity, and mortality. Medication literacy (ML) is the specific ability to safely access and understand the information available concerning medication, and to act accordingly. Currently, there are few specific instruments that ascertain the extent of ML in the general population. The aim of this work was to analyse ML in a large cohort of pharmacy customers. A total of 400 community pharmacy clients were analyzed to assess the level of ML (documental and numeracy) through the validated MedLitRxSE tool. The results showed that out of a total of 400 community pharmacy clients only 136 (34%) had an adequate degree of ML, while the rest of the clients (n = 264; 66%) were adjudged not to have this ability. Statistically significant differences were found between the different age groups in terms of ML (P < 0.001; OR = 0.312; 95% CI: 0.195-0.499), the 51-65 and >65-year age groups having a lower frequency of adequate ML (23.5 and 7.1%, respectively) than the rest of the age groups. A statistically significant increase in adequate ML was observed as the academic level of the clients increased (P < 0.001; OR = 15.403; 95% CI: 8.109-29.257). Multivariate logistic regression confirmed the influence of both variables on ML. An inadequate ML level was found in community pharmacy clients over the age of 51, and also in those with primary or non-formal studies. Our data add to our knowledge about ML, and should pharmacists and other health professionals to adopt new strategies to prevent, or at least reduce, errors in taking medicines, thus avoiding the undesirable effects of any misuse.


===MeSH Terms===
|keywords=* Aging
-
* Catecholaminergic neurons
* Feeding response
* Glucoprivation
* Rostral ventrolateral medulla
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110779
}}
{{medline-entry
|title=Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31685714


===Keywords===
|mesh-terms=* Aging
Aging; Community pharmacy; Education; Legal medicine; Patient safety
* Amino Acid Sequence
* Animals
* Antihypertensive Agents
* Blood Pressure
* Cholecystokinin
* Dipeptides
* Drug Evaluation, Preclinical
* Hypertension
* Male
* Mesenteric Arteries
* Nitric Oxide
* Peptide Library
* Proglumide
* Rats
* Rats, Inbred SHR
* Receptors, Cholecystokinin
* Vasodilation
* Vasodilator Agents
|keywords=* aging
* dipeptide library
* nitric oxide
* structure-activity relationship
* vasorelaxation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874431
}}
{{medline-entry
|title=Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655030


==Small molecule cognitive enhancer reverses age-related memory decline in mice.==
|mesh-terms=* Animals
===Abstract===
* Autoantigens
With increased life expectancy, age-associated cognitive decline becomes a growing concern, even in the absence of recognizable neurodegenerative disease. The integrated stress response (ISR) is activated during aging and contributes to age-related brain phenotypes. We demonstrate that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain, as indicated by decreased levels of activating transcription factor 4 (ATF4) and phosphorylated eukaryotic translation initiation factor eIF2. Furthermore, ISRIB treatment reverses spatial memory deficits and ameliorates working memory in old mice. At the cellular level in the hippocampus, ISR inhibition (i) rescues intrinsic neuronal electrophysiological properties, (ii) restores spine density and (iii) reduces immune profiles, specifically interferon and T cell-mediated responses. Thus, pharmacological interference with the ISR emerges as a promising intervention strategy for combating age-related cognitive decline in otherwise healthy individuals.
* Carrier Proteins
* Cellular Senescence
* Flavonoids
* Foam Cells
* Lipid Metabolism
* Lipoproteins, LDL
* Mice
* Proteasome Endopeptidase Complex
* RAW 264.7 Cells
* Signal Transduction
|keywords=* CKIP-1/REGγ signaling
* Fisetin
* Lipid accumulation
* RAW264.7
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.ejphar.2019.172748
}}
==CCL11==


===MeSH Terms===
{{medline-entry
-
|title=CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887304


===Keywords===
ISR; aging; immune dysfunction; memory; mouse; neuroscience


==Modal lifespan and disparity at older ages by leading causes of death: a Canada-U.S. comparison.==
|keywords=* Alzheimer’s disease
===Abstract===
* CCL-11
The U.S. elderly experience shorter lifespans and greater variability in age at death than their Canadian peers. In order to gain insight on the underlying factors responsible for the Canada-U.S. old-age mortality disparities, we propose a cause-of-death analysis. Accordingly, the objective of this paper is to compare levels and trends in cause-specific modal age at death ([i]M[/i]) and standard deviation above the mode ([i]SD[/i]([i]M[/i] +)) between Canada and the U.S. since the 1970s. We focus on six broad leading causes of death, namely cerebrovascular diseases, heart diseases, and four types of cancers. Country-specific [i]M[/i] and [i]SD[/i]([i]M[/i] +) estimates for each leading cause of death are calculated from [i]P[/i]-spline smooth age-at-death distributions obtained from detailed population and cause-specific mortality data. Our results reveal similar levels and trends in [i]M[/i] and [i]SD[/i]([i]M[/i] +) for most causes in the two countries, except for breast cancer (females) and lung cancer (males), where differences are the most noticeable. In both of these instances, modal lifespans are shorter in the U.S. than in Canada and U.S. old-age mortality inequalities are greater. These differences are explained in part by the higher stratification along socioeconomic lines in the U.S. than in Canada regarding the adoption of health risk behaviours and access to medical services.
* aging
* behaviour
* biomarkers
* brain
* cytokines
* eotaxin
* prevention
* schizophrenia
* stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558796
}}
==CCL17==


===MeSH Terms===
{{medline-entry
-
|title=Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33085906


===Keywords===
Canada; Causes of death; Lifespan inequalities; Modal age at death; Mortality at older ages; U.S.


==Stimulus transformation into motor action: Dynamic graph analysis reveals a posterior-to-anterior shift in brain network communication of older subjects.==
|keywords=* aging
===Abstract===
* heart
Cognitive performance slows down with increasing age. This includes cognitive processes that are essential for the performance of a motor act, such as the slowing down in response to an external stimulus. The objective of this study was to identify aging-associated functional changes in the brain networks that are involved in the transformation of external stimuli into motor action. To investigate this topic, we employed dynamic graphs based on phase-locking of Electroencephalography signals recorded from healthy younger and older subjects while performing a simple visually-cued finger-tapping task. The network analysis yielded specific age-related network structures varying in time in the low frequencies (2-7 Hz), which are closely connected to stimulus processing, movement initiation and execution in both age groups. The networks in older subjects, however, contained several additional, particularly interhemispheric, connections and showed an overall increased coupling density. Cluster analyses revealed reduced variability of the subnetworks in older subjects, particularly during movement preparation. In younger subjects, occipital, parietal, sensorimotor and central regions were-temporally arranged in this order-heavily involved in hub nodes. Whereas in older subjects, a hub in frontal regions preceded the noticeably delayed occurrence of sensorimotor hubs, indicating different neural information processing in older subjects. All observed changes in brain network organization, which are based on neural synchronization in the low frequencies, provide a possible neural mechanism underlying previous fMRI data, which report an overactivation, especially in the prefrontal and pre-motor areas, associated with a loss of hemispheric lateralization in older subjects.
* kidney
* metabolism
* obesity
|full-text-url=https://sci-hub.do/10.1152/ajpregu.00139.2020
}}
==CCL19==


===MeSH Terms===
{{medline-entry
-
|title=Age-Related Gliosis Promotes Central Nervous System Lymphoma through [[CCL19]]-Mediated Tumor Cell Retention.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31526758


===Keywords===
|mesh-terms=* Adolescent
hemispheric asymmetry reduction in older adults (HAROLD); information processing; low frequencies; motor execution; phase locking of EEG signals; posterior-anterior shift in aging (PASA)
* Adult
* Aged
* Aging
* Animals
* Astrocytes
* Blood-Brain Barrier
* Cell Line, Tumor
* Central Nervous System Neoplasms
* Chemokine CCL19
* Chemokine CXCL12
* Disease Models, Animal
* Female
* Gliosis
* Humans
* Intravital Microscopy
* Lymphoma
* Male
* Mice
* Mice, Transgenic
* Microscopy, Fluorescence, Multiphoton
* Middle Aged
* NF-kappa B
* Receptors, CCR7
* Time-Lapse Imaging
* Young Adult
|keywords=* CCL19
* CNSL
* CXCL12
* DLBCL
* PCNSL
* SCNSL
* gliosis
* lymphoma
* metastasis
* neuroinflammation
|full-text-url=https://sci-hub.do/10.1016/j.ccell.2019.08.001
}}
==CCL2==


==The Effect of MicroRNA-Mediated Exercise on Delaying Sarcopenia in Elderly Individuals.==
{{medline-entry
===Abstract===
|title=β1 Integrin regulates adult lung alveolar epithelial cell inflammation.
Sarcopenia is often regarded as an early sign of weakness and is the core element of muscle weakness in elderly individuals. Sarcopenia is closely related to the reduction of exercise, and elderly individuals often suffer from decreased muscle mass and function due to a lack of exercise. At present, studies have confirmed that resistance and aerobic exercise are related to muscle mass, strength and fiber type and to the activation and proliferation of muscle stem cells (MuSCs). Increasing evidence shows that microRNAs (miRNAs) play an important role in exercise-related changes in the quantity, composition and function of skeletal muscle. At the cellular level, miRNAs have been shown to regulate the proliferation and differentiation of muscle cells. In addition, miRNAs are related to the composition and transformation of muscle fibers and involved in the transition of MuSCs from the resting state to the activated state. Therefore, exercise may delay sarcopenia in elderly individuals by regulating miRNAs in skeletal muscle. In future miRNA-focused treatment strategies, these studies will provide valuable information for the formulation of exercise methods and will provide useful and targeted exercise programs for elderly individuals with sarcopenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873073


===MeSH Terms===
|mesh-terms=* Aging
-
* Alveolar Epithelial Cells
* Animals
* Cell Adhesion
* Chemokine CCL2
* Chemokines
* Disease Models, Animal
* Epithelium
* Integrin beta1
* Lung
* Macrophages
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Pneumonia
* Pulmonary Disease, Chronic Obstructive
* Receptors, CCR2
|keywords=* COPD
* Inflammation
* Integrins
* Macrophages
* Pulmonology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098727
}}
==CCL20==


===Keywords===
{{medline-entry
aerobic exercise; aging; microRNAs; resistance exercise; sarcopenia
|title=p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272174


==The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.==
===Abstract===
Late-onset asthma (LOA) is beginning to account for an increasing proportion of asthma patients, which is often underdiagnosed in the elderly. Studies on the possible relations between aging-related genes and LOA contribute to the diagnosis and treatment of LOA. Forkhead Box O3 (FOXO3) and TP53 are two classic aging-related genes. DNA methylation varies greatly with age which may play an important role in the pathogenesis of LOA. We supposed that the differentially methylated sites of FOXO3 and TP53 associated with clinical phenotypes of LOA may be useful biomarkers for the early screening of LOA. The mRNA expression and DNA methylation of FOXO3 and TP53 in peripheral blood of 43 LOA patients (15 mild LOA, 15 moderate LOA and 13 severe LOA) and 60 healthy controls (HCs) were determined. The association of methylated sites with age was assessed by Cox regression to control the potential confounders. Then, the correlation between differentially methylated sites (DMSs; p-value < 0.05) and clinical lung function in LOA patients was evaluated. Next, candidate DMSs combining with age were evaluated to predict LOA by receiver operating characteristic (ROC) analysis and principal components analysis (PCA). Finally, HDM-stressed asthma model was constructed, and DNA methylation inhibitor 5-Aza-2'-deoxycytidine (5-AZA) were used to determine the regulation of DNA methylation on the expression of FOXO3 and TP53. Compared with HCs, the mRNA expression and DNA methylation of FOXO3 and TP53 vary significantly in LOA patients. Besides, 8 DMSs from LOA patients were identified. Two of the DMSs, chr6:108882977 (FOXO3) and chr17:7591672 (TP53), were associated with the severity of LOA. The combination of the two DMSs and age could predict LOA with high accuracy (AUC values = 0.924). In HDM-stressed asthma model, DNA demethylation increased the expression of FOXO3 and P53. The mRNA expression of FOXO3 and TP53 varies significantly in peripheral blood of LOA patients, which may be due to the regulation of DNA methylation. FOXO3 and TP53 methylation is a suitable blood biomarker to predict LOA, which may be useful targets for the risk diagnosis and clinical management of LOA.


===MeSH Terms===
|keywords=* Aging
-
* Antiretroviral drugs
* HIV
* Inflammation
* NNRTI
* Senescence
* p53
|full-text-url=https://sci-hub.do/10.1016/j.antiviral.2020.104784
}}
==CCL28==


===Keywords===
{{medline-entry
Aging; DNA methylation; FOXO3; Late-onset asthma; TP53
|title=Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32277312


==Comparison of basal whole-body protein kinetics and muscle protein synthesis between young and older adults.==
===Abstract===
Significant research has been dedicated to counteracting age-related muscle loss, but underlying mechanisms have not been clearly established. Previous research examining differences in basal protein kinetics between young and older individuals has been limited by a lack of evaluation of protein breakdown and net balance. The aim of this study was to more comprehensively examine differences in basal protein kinetics between younger and older males and females. Basal whole-body protein kinetics and muscle fractional synthetic rate (FSR) from 91 younger (18-38 years; 52% female) and 66 older (51-81 years; 53% female) healthy adults were determined using stable isotope tracer techniques (L-[ring-  H  ]phenylalanine and L-[ring-  H  ]tyrosine). There were no group × sex interaction effects (p > .05). Older individuals had greater whole-body protein synthesis (mean difference old-young (Δ) ± SE: 28.54 ± 8.15 mg/kg LBM/hr; p = .001) and breakdown (Δ: 15.44 ± 7.33 mg/kgLBM/hr; p = .038), but a less negative net balance (Mean ± SD: Young: -31.22 ± 7.42 mg/kg LBM/hr; Old: -18.11 ± 21.60 mg/kg LBM/hr; p < .001) compared to young individuals. Basal FSR was not significantly different between young and older (Δ: 0.007 ± 0.003%/hr; p = .052). Across the age range, females had greater whole-body protein turnover (PSΔ: 19.10 ± 7.00 mg/kgLBM/hr; PBΔ: 19.22 ± 6.31 mg/kgLBM/hr; p < .01) compared to males. Results demonstrate a difference in basal whole-body protein kinetics between young and older adults, with older adults having a higher protein turnover rate and a less negative net balance. Across the age range, females were also found to have a higher turnover rate compared to males. Differences may represent a shift in older physiology toward mechanisms that increase the efficiency of amino acid reutilization, especially in women.


===MeSH Terms===
|keywords=* Aging
-
* CCL25
* CCL28
* Gut immunity
* IgA
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09877-9
}}
==CCN1==


===Keywords===
{{medline-entry
aging; anabolic resistance; protein metabolism; sarcopenia; stable isotopes
|title=Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32651107


==ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.==
===Abstract===
Ankyrin repeat and SOCS box (ASB) family members have a [i]C[/i]-terminal SOCS box and an [i]N[/i]-terminal ankyrin-related sequence of variable repeats. To date, the roles of ASB family members remain largely unknown. In the present study, by employing knockdown analysis, we investigated the effects of ASB7 on mouse oocyte meiosis. We show that specific depletion of ASB7 disrupts maturational progression and meiotic apparatus. In particular, abnormal spindle, misaligned chromosomes, and loss of cortical actin cap are frequently observed in ASB7-abated oocytes. Consistent with this observation, incidence of aneuploidy is increased in these oocytes. Meanwhile, confocal scanning reveals that loss of ASB7 impairs kinetochore-microtubule interaction and provokes the spindle assembly checkpoint during oocyte meiosis. Furthermore, we find a significant reduction of ASB7 protein in oocytes from aged mice. Importantly, increasing ASB7 expression is capable of partially rescuing the maternal age-induced meiotic defects in oocytes. Together, our data identify ASB7 as a novel player in regulating cytoskeletal organization and discover the potential effects of ASB7 on quality control of aging oocytes.


===MeSH Terms===
|keywords=* Deep endometriosis
-
* Fibrogenesis
* Mouse
* Senescence
* Sodium tanshinone IIA sulfonate
|full-text-url=https://sci-hub.do/10.1016/j.rbmo.2020.04.006
}}
{{medline-entry
|title=Inhibition of cellular communication network factor 1 ([[CCN1]])-driven senescence slows down cartilage inflammaging and osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32622876


===Keywords===
ASBs; maternal aging; meiosis; oocyte; reproduction


==Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging.==
|keywords=* CCN1
===Abstract===
* Cartilage inflammaging
Oxidative stress is a hallmark of metabolic disease, though the mechanisms that define this link are not fully understood. Irreversible modification of proteins by reactive lipid aldehydes (protein carbonylation) is a major consequence of oxidative stress in adipose tissue and the substrates and specificity of this modification are largely unexplored. Here we show that histones are avidly modified by 4-hydroxynonenal (4-HNE) in vitro and in vivo. Carbonylation of histones by 4-HNE increased with age in male flies and visceral fat depots of mice and was potentiated in genetic ([i]ob[/i]/[i]ob[/i]) and high-fat feeding models of obesity. Proteomic evaluation of in vitro 4-HNE- modified histones led to the identification of both Michael and Schiff base adducts. In contrast, mapping of sites in vivo from obese mice exclusively revealed Michael adducts. In total, we identified 11 sites of 4-hydroxy hexenal (4-HHE) and 10 sites of 4-HNE histone modification in visceral adipose tissue. In summary, these results characterize adipose histone carbonylation as a redox-linked epigenomic mark associated with metabolic disease and aging.
* Chondrocyte cluster
* Osteoarthritis
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115522
}}
{{medline-entry
|title=The senescence-associated matricellular protein [[CCN1]] in plasma of human subjects with idiopathic pulmonary fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765873


===MeSH Terms===
|mesh-terms=* Aged
-
* Cellular Senescence
* Cysteine-Rich Protein 61
* Disease Progression
* Enzyme-Linked Immunosorbent Assay
* Female
* Humans
* Idiopathic Pulmonary Fibrosis
* Male
* Middle Aged
* Outcome Assessment, Health Care
* Predictive Value of Tests
* Survival Rate
|keywords=* CCN1
* Cellular senescence
* Idiopathic pulmonary fibrosis
* Transplant-free survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023981
}}
==CCN3==


===Keywords===
{{medline-entry
4-HHE (4-hydroxy hexenal); 4-HNE (4-hydroxynonenal); adipose; aging; carbonylation; epigenomics; histone
|title=[[CCN3]] Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304321


==Comparison of morphometric, structural, mechanical, and physiologic characteristics of human superficial femoral and popliteal arteries.==
===Abstract===
Peripheral arterial disease differentially affects the superficial femoral (SFA) and the popliteal (PA) arteries, but their morphometric, structural, mechanical, and physiologic differences are poorly understood. SFAs and PAs from 125 human subjects (age 13-92, average 52±17 years) were compared in terms of radii, wall thickness, and opening angles. Structure and vascular disease were quantified using histology, mechanical properties were determined with planar biaxial extension, and constitutive modeling was used to calculate the physiologic stress-stretch state, elastic energy, and the circumferential physiologic stiffness. SFAs had larger radii than PAs, and both segments widened with age. Young SFAs were 5% thicker, but in old subjects the PAs were thicker. Circumferential (SFA: 96→193°, PA: 105→139°) and longitudinal (SFA: 139→306°, PA: 133→320°) opening angles increased with age in both segments. PAs were more diseased than SFAs and had 11% thicker intima. With age, intimal thickness increased 8.5-fold, but medial thickness remained unchanged (620μm) in both arteries. SFAs had 30% more elastin than the PAs, and its density decreased ~50% with age. SFAs were more compliant than PAs circumferentially, but there was no difference longitudinally. Physiologic circumferential stress and stiffness were 21% and 11% higher in the SFA than in the PA across all ages. The stored elastic energy decreased with age (SFA: 1.4→0.4kPa, PA: 2.5→0.3kPa). While the SFA and PA demonstrate appreciable differences, most of them are due to vascular disease. When pathology is the same, so are the mechanical properties, but not the physiologic characteristics that remain distinct due to geometrical differences.


===MeSH Terms===
|keywords=* CCN3
-
* abnormally invasive placenta
* invasion
* preeclampsia
* senescence
* trophoblast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701218
}}
{{medline-entry
|title=[[CCN3]] (NOV) Drives Degradative Changes in Aging Articular Cartilage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066270


===Keywords===
Aging; Constitutive modeling; Mechanical properties; Popliteal artery; Regional differences; superficial femoral artery


==Nutrient Signaling, Stress Response, and Inter-organelle Communication Are Non-canonical Determinants of Cell Fate.==
|keywords=* CCN3
===Abstract===
* NOV
Isogenic cells manifest distinct cellular fates for a single stress; however, the nongenetic mechanisms driving such fates remain poorly understood. Here, we implement a robust multi-channel live-cell imaging approach to uncover noncanonical factors governing cell fate. We show that in response to acute glucose removal (AGR), budding yeast undergoes distinct fates, becoming either quiescent or senescent. Senescent cells fail to resume mitotic cycles following glucose replenishment but remain responsive to nutrient stimuli. Whereas quiescent cells manifest starvation-induced adaptation, senescent cells display perturbed endomembrane trafficking and defective nucleus-vacuole junction (NVJ) expansion. Surprisingly, senescence occurs even in the absence of lipid droplets. Importantly, we identify the nutrient-sensing kinase Rim15 as a key biomarker predicting cell fates before AGR stress. We propose that isogenic yeast challenged with acute nutrient shortage contains determinants influencing post-stress fate and demonstrate that specific nutrient signaling, stress response, trafficking, and inter-organelle biomarkers are early indicators for long-term fate outcomes.
* SASP
* aging
* cellular communication network factor 3
* oxidative stress
* p21
* p53
* primary chondrocytes
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593953
}}
==CCND1==


===MeSH Terms===
{{medline-entry
-
|title=Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592933


===Keywords===
|mesh-terms=* Cells, Cultured
Bayesian analysis; LD; NVJ; cell cycle; cellular decision making; lipid droplet; nucleus-vacuole junction; quantitative imaging; quiescence; senescence; statistical evidence
* Cellular Senescence
* Dental Pulp
* Doxorubicin
* Humans
* Hydrogen Peroxide
* Stem Cells
* Ultraviolet Rays
|keywords=* Cell cycle
* ROS
* Stress induced senescence
* Ultraviolet irradiation
* p21
|full-text-url=https://sci-hub.do/10.1016/j.archoralbio.2020.104819
}}
==CCND3==


==Winter of our contentment: Examining risk, pleasure, and emplacement in later-life physical activity.==
{{medline-entry
===Abstract===
|title=The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.
In the West, many in the media and the health sector emphasize physical activity as important for the old, so that they can circumvent the impacts of aging and the associated costs. At the same time, neoliberal health discourse advises older people to avoid activities that may cause injuries, such as slips and falls, creating contradictions for older people who participate in sports on ice. In light of these mixed messages, this paper explores how older men understand their bodies through their participation in the seemingly risky sport of ice hockey. I conducted eighteen semi-structured interviews with older Canadian men who played hockey, identifying common themes related to aging, embodiment, risk and pleasure. Participants were aware that common-sense discourse produced hockey as risky for the old, but often downplayed this risk, privileging pleasure. Discourses associated with pleasure acted as an important way for older men to examine their bodies and contemplate the significance of hockey in their lives. Through the comradery players developed with each other, their interactions with the material objects of hockey, and their emplacement on hockey rinks and arenas, they found ways to celebrate their bodies as both aging and capable of experiencing pleasure - implicitly challenging neoliberal discourses of old age in the process.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32727592


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Aging; Embodiment; Emplacement; Hockey; Materialism; Men; Neoliberalism; Pleasure; Risk
* Immunosuppression
* Osteogenic differentiation
* Periodontal ligament stem cells
* Peripheral blood mononuclear cells
* Tissue engineering
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392710
}}
==CCR2==


==The Many Lives of Myc in the Pancreatic β-Cell.==
{{medline-entry
===Abstract===
|title=Hip Fracture Leads to Transitory Immune Imprint in Older Patients.
Diabetes results from insufficient numbers of functional pancreatic β-cells. Thus, increasing the number of available functional β-cells ex vivo for transplantation, or regenerating them in situ in diabetic patients, is a major focus of diabetes research. The transcription factor, Myc, discovered decades ago, lies at the nexus of most, if not all, known proliferative pathways. Based on this, many studies in the 1990's and early 2000's explored the potential of harnessing Myc expression to expand β-cells for diabetes treatment. Nearly all these studies in β-cells used pathophysiological or supraphysiological levels of Myc and reported enhanced β-cell death, de-differentiation or the formation of insulinomas if co-overexpressed with Bcl-xL, an inhibitor of apoptosis. This obviously reduced the enthusiasm for Myc as a therapeutic target for β-cell regeneration. However, recent studies indicate that "gentle" induction of Myc expression enhances β-cell replication without induction of cell death or loss of insulin secretion, suggesting that appropriate levels of Myc could have therapeutic potential for β-cell regeneration. Furthermore, although it has been known for decades that Myc is induced by glucose in β-cells very little is known about how this essential anabolic transcription factor perceives and responds to nutrients and increased insulin demand in vivo. Here we summarize the previous and recent knowledge of Myc in the β-cell, its potential for β-cell regeneration and its physiological importance for neonatal and adaptive β-cell expansion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33072114


===MeSH Terms===
-


===Keywords===
|keywords=* acute stress
Adaptation; DNA methylation; Myc (c-Myc); aging; beta cell (B-cell); cell proliferation; diabetes; glucose
* aging
* immune response
* inflammation
* regulation loop
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533556
}}
{{medline-entry
|title=The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32615332


==The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.==
===Abstract===
Further knowledge on modifiable aging risk factors is required to mitigate the increasing burden of age-related diseases in a rapidly growing global demographic of elderly individuals. We explored the effect of everyday exposure to polycyclic aromatic hydrocarbons (PAHs), which are fundamental constituents of air pollution, on cellular biological aging. This was determined via the analysis of leukocyte telomere length (LTL), mitochondrial DNA copy number (LmtDNAcn), and by the formation of anti-benzo[a]pyrene diolepoxide (B[a]PDE-DNA) adducts. The study population consisted of 585 individuals living in North-East Italy. PAH exposure (diet, indoor activities, outdoor activities, traffic, and residential exposure) and smoking behavior were assessed by questionnaire and anti-B[a]PDE-DNA by high-performance-liquid-chromatography. LTL, LmtDNAcn and genetic polymorphisms [glutathione S-transferase M1 and T1 (GSTM1; GSTT1)] were measured by polymerase chain reaction. Structural equation modelling analysis evaluated these complex relationships. Anti-B[a]PDE-DNA enhanced with PAH exposure (p = 0.005) and active smoking (p = 0.0001), whereas decreased with detoxifying GSTM1 (p = 0.021) and in females (p = 0.0001). Subsequently, LTL and LmtDNAcn reduced with anti-B[a]PDE-DNA (p = 0.028 and p = 0.018), particularly in males (p = 0.006 and p = 0.0001). Only LTL shortened with age (p = 0.001) while elongated with active smoking (p = 0.0001). Besides this, the most significant determinants of PAH exposure that raised anti-B[a]PDE-DNA were indoor and diet (p = 0.0001), the least was outdoor (p = 0.003). New findings stemming from our study suggest that certain preventable everyday life exposures to PAHs reduce LTL and LmtDNAcn. In particular, the clear association with indoor activities, diet, and gender opens new perspectives for tailored preventive measures in age-related diseases. Everyday life exposure to polycyclic aromatic hydrocarbons reduces leukocyte telomere length and mitochondrial DNA copy number through anti-B[a]PDE-DNA adduct formation.


===MeSH Terms===
|keywords=* Aging
-
* CCR2
* Fertility
* Follicle
* Ovary
|full-text-url=https://sci-hub.do/10.1016/j.jri.2020.103174
}}
{{medline-entry
|title=Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32543720


===Keywords===
Biological aging; DNA adduct; Mitochondrial DNA copy number; Polycyclic aromatic hydrocarbon; Structural equation modelling; Telomere length


==A Study on the Influence of Social Leisure Activities on the Progression to the Stage of Frailty in Korean Seniors.==
|keywords=* inflammatory macrophage
===Abstract===
* kidney function
In this study, we performed a logistic regression analysis according to the frequency of participation in social leisure activities (education, clubs, social groups, volunteer activities, religious activities, and senior citizens' welfare center use) by men and women aged ≥ 65 years. We investigated the frequency of participation in social leisure activities and their association with the level of frailty (health vs. pre-frailty, health vs. frailty, pre-frailty vs. frailty). This study included 10,297 older adults (men: 4128, women: 6169) who participated in the 2017 National Survey of Older Koreans, and were divided into three groups (healthy, pre-frailty, and frailty). Five frailty index components were used to measure the frailty level. There was a positive relationship between the elderly's religious activities, four times a week, from the healthy stage to the frailty stage, from the healthy stage to the pre-frailty stage, and from the pre-frailty stage to the frailty. In addition, positive associations emerged in leisure activities and club activities, respectively, from the healthy stage to the frailty stage (once a week, respectively). Positive association also emerged from the healthy stage to the pre-frailty and from the pre-frailty stage to the frailty stage (once a month to once in a two-week period).
* non-resolving inflammation
* obesogenic aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704037
}}
{{medline-entry
|title=Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154790


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Korean senior; aging; frailty; national survey; older adults; social leisure activities
* Bone marrow transplantation
* Cardiology
* Hematopoietic stem cells
* Macrophages
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213793
}}
{{medline-entry
|title=Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by [[CCR2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843499


==Caloric restriction: implications for sarcopenia and potential mechanisms.==
|mesh-terms=* Aging
===Abstract===
* Animals
Sarcopenia is a potential risk factor for weakness, disability and death in elderly individuals. Therefore, seeking effective methods to delay and treat sarcopenia and to improve the quality of life of elderly individuals is a trending topic in geriatrics. Caloric restriction (CR) is currently recognized as an effective means to extend the lifespan and delay the decline in organ function caused by aging. In this review, we describe the effects of CR on improving muscle protein synthesis, delaying muscle atrophy, regulating muscle mitochondrial function, maintaining muscle strength, promoting muscle stem cell (MuSC) regeneration and differentiation, and thus protecting against sarcopenia. We also summarize the possible cellular mechanisms by which CR delays sarcopenia. CR can delay sarcopenia by reducing the generation of oxygen free radicals, reducing oxidative stress damage, enhancing mitochondrial function, improving protein homeostasis, reducing iron overload, increasing autophagy and apoptosis, and reducing inflammation. However, the relationships between CR and genetics, sex, animal strain, regimen duration and energy intake level are complex. Therefore, further study of the proper timing and application method of CR to prevent sarcopenia is highly important for the aging population.
* Body Weight
* Chemokine CCL2
* Disease Models, Animal
* Female
* Gene Expression Profiling
* Inflammation
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* Non-alcoholic Fatty Liver Disease
* Organ Size
* Receptors, CCR2


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013280
-
}}
{{medline-entry
|title=Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545552


===Keywords===
|mesh-terms=* Aged
aging; calorie restriction; cellular mechanism; sarcopenia
* Cell Line, Tumor
* Cell Movement
* Cell Proliferation
* Cellular Microenvironment
* Cellular Senescence
* Chemokine CCL2
* Colorectal Neoplasms
* Disease Progression
* Down-Regulation
* Doxorubicin
* Female
* Glucuronidase
* Human Umbilical Vein Endothelial Cells
* Humans
* Male
* Middle Aged
* NF-kappa B
* Neoplasm Invasiveness
* Proportional Hazards Models
* Signal Transduction
* Stromal Cells
|keywords=* CCL2
* Klotho
* colorectal cancer
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822285
}}
==CCR3==


==Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.==
{{medline-entry
===Abstract===
|title=Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.
Food insecurity is associated with increased morbidity and mortality in people living with HIV on antiretroviral therapy, but its relationship with immune dysregulation, a hallmark of HIV infection and comorbidity, is unknown. In 241 women participating in the Women's Interagency HIV Study, peripheral blood mononuclear cells were characterized by flow cytometry to identify cell subsets, comprising surface markers of activation (%CD38+HLADR+), senescence (%CD57+CD28-), exhaustion (%PD-1+), and co-stimulation (%CD57- CD28+) on CD4+ and CD8+ T-cells. Mixed-effects linear regression models were used to assess the relationships of food insecurity with immune outcomes, accounting for repeated measures at up to three study visits and adjusting for sociodemographic and clinical factors. At the baseline study visit, 71% of participants identified as non-Hispanic Black, 75% were virally suppressed, and 43% experienced food insecurity. Food insecurity was associated with increased activation of CD4+ and CD8+ T-cells, increased senescence of CD8+ T-cells, and decreased co-stimulation of CD4+ and CD8+ T-cells (all p<0.05), adjusting for age, race/ethnicity, income, education, substance use, smoking, HIV viral load, and CD4 cell count. In stratified analyses, the association of food insecurity with CD4+ T-cell activation was more pronounced in women with uncontrolled HIV (viral load >40 copies/mL and CD4 <500 cells/mm 3), but remained statistically significant in those with controlled HIV. Food insecurity may contribute to the persistent immune activation and senescence in women living with HIV on antiretroviral therapy, independently of HIV control. Reducing food insecurity may be important for decreasing non-AIDS-related disease risk in this population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32033185


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Extracellular Matrix
* Female
* Germ Cells
* Granulosa Cells
* Hyaluronan Receptors
* Hyaluronic Acid
* Inflammation
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Molecular Weight
* Ovary
* Stromal Cells
|keywords=* hyaluronan fragments
* inflammation
* ovarian biology
* reproductive aging
* stroma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036885
}}
==CCR5==


===Keywords===
{{medline-entry
HIV; exhaustion; food insecurity; immune activation; senescence
|title=[Enhancement can do harm].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532388


==Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons.==
|mesh-terms=* Adult
===Abstract===
* Aged
Sensorimotor performance declines during advanced age, partially due to deficits in somatosensory acuity. Cortical receptive field expansion contributes to somatosensory deficits, suggesting increased excitability or decreased inhibition in primary somatosensory cortex (S1) pyramidal neurons. To ascertain changes in excitability and inhibition, we measured both properties in neurons from vibrissal S1 in brain slices from young and aged mice. Because adapting and non-adapting neurons-the principal pyramidal types in layer 5 (L5)-differ in intrinsic properties and inhibitory inputs, we determined age-dependent changes according to neuron type. We found an age-dependent increase in intrinsic excitability in adapting neurons, caused by a decrease in action potential threshold. Surprisingly, in non-adapting neurons we found both an increase in excitability caused by increased input resistance, and a decrease in synaptic inhibition. Spike frequency adaptation, already small in non-adapting neurons, was further reduced by aging, whereas sag, a manifestation of I , was increased. Therefore, aging caused both decreased inhibition and increased intrinsic excitability, but these effects were specific to pyramidal neuron type.
* CRISPR-Cas Systems
* China
* Embryo Research
* Gene Editing
* Gene Silencing
* Genetic Enhancement
* Genome-Wide Association Study
* HIV Infections
* HIV-1
* Humans
* Longevity
* Middle Aged
* Receptors, CCR5


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1051/medsci/2019136
-
}}
==CCS==


===Keywords===
{{medline-entry
Action potential threshold; Aging; Barrel cortex; Critical frequency; GABA; Hyperexcitability; Inhibition; Input resistance; Intrinsic excitability; Layer 5; Somatosensory cortex; Spike frequency adaptation; sag
|title=Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33306315


==Increased functional connectivity supports language performance in healthy aging despite gray matter loss.==
===Abstract===
Although language is quite preserved from aging, it remains unclear whether age-related differences lead to a deterioration or reorganization in language functional networks, or to different dynamics with other domains (e.g., the multiple-demand system). The present study is aimed at examining language networks, using resting-state functional magnetic resonance imaging in typical aging in relation to language performance. Twenty-three (23) younger adults and 24 healthy older adults were recruited. Volumetric gray matter differences between the 2 groups were assessed using voxel-based morphometry. Then, seed-based analyses, integrated local correlations in core regions of the language network, and within- and between-network connectivity were performed. We expected less extended connectivity maps, local coherence diminution, and higher connectivity with the multiple-demand system in older adults. On the contrary, analyses showed language network differences in healthy aging (i.e., increased connectivity with areas inside and outside language network), but no deterioration, despite widespread atrophy in older adults. Integrated local correlation revealed alterations that were unnoticeable with other analyses. Although gray matter loss was not correlated with language performance, connectivity differences were positively correlated with fluency performance in the older group. These results differ from the literature concerning other cognitive networks in aging in that they show extra internetwork connections without a decrease in intranetwork language connections. This reorganization could explain older adults' good language performance and could be interpreted in accordance with the scaffolding theory of aging and cognition.


===MeSH Terms===
|keywords=* Aging
-
* Canada
* Confidence Intervals
* Death
* Frail Elderly
* Frailty
* Heart
* Multivariate Analysis
* Prognosis
* Risk Factors
|full-text-url=https://sci-hub.do/10.21470/1678-9741-2019-0484
}}
{{medline-entry
|title=Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32925053


===Keywords===
Aging; Functional connectivity; Language; Resting-state; fMRI


==Development of Energy-Efficient Superhydrophobic Polypropylene Fabric by Oxygen Plasma Etching and Thermal Aging.==
|keywords=* Atrophy
===Abstract===
* cognition
This study developed a human-friendly energy-efficient superhydrophobic polypropylene (PP) fabric by oxygen plasma etching and short-term thermal aging without additional chemicals. The effect of the microroughness on the superhydrophobicity was examined by adjusting the weave density. After the PP fabric was treated with oxygen plasma etching for 15 min and thermal aging at 120 °C for 1 h (E15H120 1 h), the static contact and shedding angles were 162.7° ± 2.4° and 5.2° ± 0.7° and the energy consumption was 136.4 ± 7.0 Wh. Oxygen plasma etching for 15 min and thermal aging at 120 °C for 24 h (E15H120 24 h) resulted in a static contact and shedding angle of 180.0° ± 0.0° and 1.8° ± 0.2° and energy consumption of 3628.5 ± 82.6 Wh. E15H120 1 h showed a lower shedding angle but had a higher sliding angle of 90°. E15H120 24 h exhibited shedding and sliding angles of less than 10°. Regardless of the thermal aging time, superhydrophobicity was higher in high-density fabrics than in low-density fabrics. The superhydrophobic PP fabric had a similar water vapor transmission rate and air permeability with the untreated PP fabric, and it showed a self-heading property after washing followed by tumble drying and hot pressing.
* imaging markers
* medial temporal lobe
* microbleeds
* normal aging
|full-text-url=https://sci-hub.do/10.3233/JAD-200559
}}
{{medline-entry
|title=Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31846965


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Amyloid beta-Peptides
* Apolipoprotein E4
* Brain
* Cognitive Aging
* Female
* Hippocampus
* Humans
* Longitudinal Studies
* Magnetic Resonance Imaging
* Male
* Positron-Emission Tomography
|keywords=* APOE
* Aging
* Amyloid
* Hippocampus
|full-text-url=https://sci-hub.do/10.1159/000504302
}}
{{medline-entry
|title=Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31803008


===Keywords===
energy-efficient; plasma etching; polypropylene; self-cleaning; superhydrophobicity; thermal aging; weave density


==The Receptor for Advanced Glycation End Product (RAGE) Pathway in COVID-19.==
|keywords=* APOE genotyping
===Abstract===
* amyloid deposition
Coronavirus disease-2019 (COVID-19) with lung involvement frequently causes morbidity and mortality. Advanced age appears to be the most important risk factor. The receptor for advanced glycation end-product (RAGE) pathway is considered to play important roles in the physiological aging and pathogenesis of lung diseases. This study aims to investigate the possible relationship between COVID-19 and RAGE pathway. This study included 23 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum soluble-RAGE (sRAGE) levels were determined using enzyme-linked immunosorbent assay. The sRAGE levels were significantly higher in the asymptomatic group than in the control group. Age, fibrinogen, C-reactive protein, and ferritin levels were higher and the sRAGE level was lower in the patients with lung involvement than in the asymptomatic patients. In the present study, patients with high sRAGE levels were younger and had asymptomatic COVID-19. Patients with low sRAGE levels were elderly patients with lung involvement, which indicates that the RAGE pathway plays an important role in the aggravation of COVID-19.
* magnetic resonance imaging
* normal aging
* positron emission tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872975
}}
{{medline-entry
|title=Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783200


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Aging; COVID-19; Co-morbidity; Infection; Inflammation; The receptor for advanced glycation end product (RAGE)
* Endothelial dysfunction
* Osteoporosis
* Subclinical atherosclerosis
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2019.11.007
}}
==CD14==


==Impact of an 8-Year Intensive Lifestyle Intervention on an Index of Multimorbidity.==
{{medline-entry
===Abstract===
|title=Human innate immune cell crosstalk induces melanoma cell senescence.
Type 2 diabetes mellitus and obesity are sometimes described as conditions that accelerate aging. Multidomain lifestyle interventions have shown promise to slow the accumulation of age-related diseases, a hallmark of aging. However, they have not been assessed among at-risk individuals with these two conditions. We examined the relative impact of 8 years of a multidomain lifestyle intervention on an index of multimorbidity. Randomized controlled clinical trial comparing an intensive lifestyle intervention (ILI) that targeted weight loss through caloric restriction and increased physical activity with a control condition of diabetes support and education (DSE). Sixteen U.S. academic centers. A total of 5,145 volunteers, aged 45 to 76, with established type 2 diabetes mellitus and overweight or obesity who met eligibility criteria for a randomized controlled clinical trial. A multimorbidity index that included nine age-related chronic diseases and death was tracked over 8 years of intervention delivery. Among individuals assigned to DSE, the multimorbidity index scores increased by an average of .98 (95% confidence interval [CI] = .94-1.02) over 8 years, compared with .89 (95% CI = .85-.93) among those in the multidomain ILI, which was a 9% difference (P = .003). Relative intervention effects were similar among individuals grouped by baseline body mass index, age, and sex, and they were greater for those with lower levels of multimorbidity index scores at baseline. Increases in multimorbidity over time among adults with overweight or obesity and type 2 diabetes mellitus may be slowed by multidomain ILI. J Am Geriatr Soc 68:2249-2256, 2020.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32939325


===MeSH Terms===
-


===Keywords===
|keywords=* NK cell
aging; multidomain intervention; obesity; type 2 diabetes mellitus
* cytokines
* melanoma
* senescence
* slanMo
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470184
}}
{{medline-entry
|title=Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887359


==Longitudinal profiling of the blood transcriptome in an African green monkey aging model.==
===Abstract===
African green monkeys (AGMs, [i]Chlorocebus aethiops[/i]) are Old World monkeys which are used as experimental models in biomedical research. Recent technological advances in next generation sequencing are useful for unraveling the genetic mechanisms underlying senescence, aging, and age-related disease. To elucidate the normal aging mechanisms in older age, the blood transcriptomes of nine healthy, aged AGMs (15‒23 years old), were analyzed over two years. We identified 910‒1399 accumulated differentially expressed genes (DEGs) in each individual, which increased with age. Aging-related DEGs were sorted across the three time points. A major proportion of the aging-related DEGs belonged to gene ontology (GO) categories involved in translation and rRNA metabolic processes. Next, we sorted common aging-related DEGs across three time points over two years. Common aging-related DEGs belonged to GO categories involved in translation, cellular component biogenesis, rRNA metabolic processes, cellular component organization, biogenesis, and RNA metabolic processes. Furthermore, we identified 29 candidate aging genes that were upregulated across the time series analysis. These candidate aging genes were linked to protein synthesis. This study describes a changing gene expression pattern in AGMs during aging using longitudinal transcriptome sequencing. The candidate aging genes identified here may be potential targets for the treatment of aging.


===MeSH Terms===
|keywords=* CTX
-
* DC-STAMP
* DNA methylation
* aging
* cell fusion
* epigenetics
* menopause
* multinucleation
* osteoclast
* osteoclastogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504560
}}
{{medline-entry
|title=Association of [[CD14]] with incident dementia and markers of brain aging and injury.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31818907


===Keywords===
|mesh-terms=* Aged
African green monkey; aging; aging candidate gene; longitudinal transcriptome
* Aged, 80 and over
* Aging
* Atrophy
* Biomarkers
* Brain
* Cognitive Dysfunction
* Dementia
* Female
* Humans
* Incidence
* Lipopolysaccharide Receptors
* Longitudinal Studies
* Male
* Middle Aged


==Age-related gene expression changes in lumbar spinal cord: Implications for neuropathic pain.==
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108812
===Abstract===
}}
Clinically, pain has an uneven incidence throughout lifespan and impacts more on the elderly. In contrast, preclinical models of pathological pain have typically used juvenile or young adult animals to highlight the involvement of glial populations, proinflammatory cytokines, and chemokines in the onset and maintenance of pathological signalling in the spinal dorsal horn. The potential impact of this mismatch is also complicated by the growing appreciation that the aged central nervous system exists in a state of chronic inflammation because of enhanced proinflammatory cytokine/chemokine signalling and glial activation. To address this issue, we investigated the impact of aging on the expression of genes that have been associated with neuropathic pain, glial signalling, neurotransmission and neuroinflammation. We used qRT-PCR to quantify gene expression and focussed on the dorsal horn of the spinal cord as this is an important perturbation site in neuropathic pain. To control for global vs region-specific age-related changes in gene expression, the ventral half of the spinal cord was examined. Our results show that expression of proinflammatory chemokines, pattern recognition receptors, and neurotransmitter system components was significantly altered in aged (24-32 months) versus young mice (2-4 months). Notably, the magnitude and direction of these changes were spinal-cord region dependent. For example, expression of the chemokine, Cxcl13, increased 119-fold in dorsal spinal cord, but only 2-fold in the ventral spinal cord of old versus young mice. Therefore, we propose the dorsal spinal cord of old animals is subject to region-specific alterations that prime circuits for the development of pathological pain, potentially in the absence of the peripheral triggers normally associated with these conditions.
{{medline-entry
|title=Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681320


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Aging
* Animals
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Biomarkers
* Bone Regeneration
* Bone and Bones
* Female
* Fractures, Bone
* Gene Expression
* Lipopolysaccharide Receptors
* Macrophages
* Osteotomy
* Rats, Sprague-Dawley
* Wound Healing
|keywords=* CD14+ cells
* aging
* angiogenesis
* bone regeneration
* compromised healing
* macrophage
* monocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813416
}}
==CD19==


===Keywords===
{{medline-entry
Cxcl13; Dorsal horn; ageing; aging; astrocytes; chemokines; glia; inflammation; microglia
|title=Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634527


==Lignin-derived phenolic compounds in cachaça aged in new barrels made from two oak species.==
|mesh-terms=* Animals
===Abstract===
* Antigens, CD19
Aging cachaça in wooden barrels is essential to improve its quality. The level of maturation of distillates can be determined based on the contents of aging-marker phenolic compounds extracted from the lignin of the wooden barrel. This study aimed to characterize the aging process of cachaça by analyzing the mechanism of lignin degradation during its maturation in new barrels made from two oak species, European ([i]Quercus petraea[/i]) and American ([i]Quercus alba[/i]), for up to 60 months. Evaluation was based on the analyses of cinnamic aldehydes (sinapaldehyde and coniferaldehyde), benzoic aldehydes (syringaldehyde and vanillin), and benzoic acids (syringic and vanillic acids) using high-performance liquid chromatography. Oak species had a significant effect on all the studied phenolic compounds. Higher contents of all the identified phenolic compounds were found in cachaça aged in barrels made from American oak. The total contents of benzoic acids (vanillic and syringic acids) can be considered for predicting the level of maturation of cachaça aged in barrels made from both oak species. Based on the composition of maturation-related congeners, it is likely that for cachaça each year of aging in new oak barrels corresponds to approximately 5 years of aging for spirits in general commercialized worldwide.
* Cell Line, Tumor
* Combined Modality Therapy
* Disease-Free Survival
* HEK293 Cells
* Healthy Volunteers
* Humans
* Immunologic Memory
* Immunotherapy, Adoptive
* Longevity
* Lymphoma, B-Cell
* Mice
* Neoplasm Recurrence, Local
* Receptors, Chimeric Antigen
* Recombinant Proteins
* Remission Induction
* T-Lymphocytes
* Time Factors
* Transduction, Genetic
* Transplantation, Autologous
* Xenograft Model Antitumor Assays
|keywords=* Autologous CD19 T cells
* Chimeric antigen receptor
* Memory T cells
* Sequential therapy
|full-text-url=https://sci-hub.do/10.1016/j.canlet.2019.10.022
}}
==CD27==


===MeSH Terms===
{{medline-entry
-
|title=The Interplay between [[CD27]]  and [[CD27]]  B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32130900


===Keywords===
Aging; Food analysis; Food technology; Lignin; Oak species; Phenolic compounds; Sugarcane spirit


==Depresión en el adulto mayor intervenido quirúrgicamente.==
|keywords=* CD27
===Abstract===
* VH repertoire
To determine the degree of depression in elderly adults after surgery and its relation with the duration of anesthesia. We conducted an observational, comparative, prospective and longitudinal study. We included 73 elderly adults aged 60 scheduled for different surgical procedures. Their degree of depression was evaluated prior to and after the surgery with the short version of the Yasavage Geriatric Depression Scale. They were classified according to the score: no depression (0-5), mild depression (6-9) and established depression (10-15). The relation of depression with anesthesia duration was determined. The sample size was calculated for proportions. Descriptive statistics were used as well as χ  (p < 0.05). In the first evaluation 47 patients (64%) were not depressed, 21 (29%) had mild depression and 5 (7%) had established depression. In the second evaluation, we found that 44 patients (60%) were not depressed, 21 (29%) had mild depression and 8 (11%) had established depression. The relation between depression and anesthesia duration was χ  = 0.81. We did not establish a relation between depression and anesthesia duration in surgically intervened elderly adults.
* aging
* germinal center
* immunodeficiency
* immunological memory
* memory B cells
* pregnancy
* spleen
* vaccine
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2020.02.022
}}
{{medline-entry
|title=CMV-independent increase in [[CD27]]-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31993214


===MeSH Terms===
-


===Keywords===
|keywords=* Biomarkers
Adult; Adulto; Aging; Anestesia; Anesthesia; Depresión; Depression; Envejecimiento; Espinal; Spinal
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972903
}}
{{medline-entry
|title=Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8  T cells in human cutaneous leishmaniasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31925782


==A systematic review of psychosocial interventions for older adults living with HIV.==
|mesh-terms=* CD56 Antigen
===Abstract===
* CD57 Antigens
The rapidly growing segment of older adults living with HIV faces unique set of psychosocial challenges that may differ from their younger counterparts. The objective of this review is to systematically examine current published literature on interventions designed to improve the psychosocial wellbeing of older adults living with HIV. A pre-specified search strategy was applied to four databases: PubMed, CINAHL Plus with Text, PsycINFO, and Health Source. Authors reviewed published studies on psychosocial interventions for older adults with HIV and reported psychosocial variables as primary outcomes of the interventions. The final review included nine intervention studies. Psychosocial outcomes measured across multiple studies included depression, quality of life, social support, cognitive functioning, and coping skills. Some studies also measured physical activity, HIV-related discrimination, lack of affordable housing, and access to substance abuse treatment. Our study suggests a paucity of psychosocial intervention research on adults aging with HIV. This review suggests that most psychosocial interventions had small to moderate effects in improving the psychosocial wellbeing of older people living with HIV. Findings highlight the need for clinical, community, and home-based interventions to ensure that individuals can achieve a higher quality of life while aging with HIV.
* Case-Control Studies
* Cellular Senescence
* Cytotoxicity, Immunologic
* Female
* Gene Expression Regulation
* Host-Parasite Interactions
* Humans
* Interferon-gamma
* Killer Cells, Natural
* Lectins, C-Type
* Leishmania braziliensis
* Leishmaniasis, Cutaneous
* Male
* Oligosaccharides
* Receptors, Immunologic
* Severity of Illness Index
* Sialyl Lewis X Antigen
* Signal Transduction
* Skin
* T-Lymphocytes, Cytotoxic
|keywords=*
Leishmania braziliensis


===MeSH Terms===
* CD8+ T cells
-
* cellular senescence
* cutaneous leishmaniasis
* immunopathology
* natural killer cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078002
}}
{{medline-entry
|title=[[CD27]]- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31423147


===Keywords===
Aging; Depression; HIV; Older adults; Psychosocial intervention; Stress


==Comparison of the Effects of KE and AED Peptides on Functional Activity of Human Skin Fibroblasts during Their Replicative Aging.==
|keywords=* Aging
===Abstract===
* B cell
We studied the effect of KE and AED peptides on the expression of sirtuin-1, sirtuin-6, collagen I, cytokines (IL-1, TGF-β), and transcription factor NF-κB in human skin fibroblasts during their replicative aging. Immunocytochemical analysis and confocal microscopy showed that KE peptide reduces the synthesis of factors of the inflammatory response IL-1, NF-κB, and TGF-β and stimulates the synthesis of sirtuin-6. KE peptide normalizes the immunological function of human skin fibroblasts during their aging. AED peptide activates the synthesis of sirtuin-1, sirtuin-6, and collagen I in human skin fibroblasts during their replicative aging, which attests to its geroprotective effect.
* Frailty
* Immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693136
}}
==CD28==


===MeSH Terms===
{{medline-entry
-
|title=Premature CD4  T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269101


===Keywords===
collagen I; human skin fibroblasts; replicative aging; short peptides; sirtuins


==Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease.==
|keywords=* CD28null T cells
===Abstract===
* CD4+ T cells
Sphingolipids, which function as plasma membrane lipids and signaling molecules, are highly enriched in neuronal and myelin membranes in the nervous system. They are degraded in lysosomes by a defined sequence of enzymatic steps. In the related group of disorders, the sphingolipidoses, mutations in the genes that encode the individual degradative enzymes cause lysosomal accumulation of sphingolipids and often result in severe neurodegenerative disease. Here we review the information indicating that microglia, which actively clear sphingolipid-rich membranes in the brain during development and homeostasis, are directly affected by these mutations and promote neurodegeneration in the sphingolipidoses. We also identify parallels between the sphingolipidoses and more common forms of neurodegeneration, which both exhibit evidence of defective sphingolipid clearance in the nervous system.
* acute coronary syndrome
* immunosenescence
* infection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673853
}}
{{medline-entry
|title=The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193356


===MeSH Terms===
-


===Keywords===
|keywords=* angiogenic T cells
Aging; Alzheimer's disease; Microglia; Parkinson's disease; Sphingolipidoses; Sphingolipids
* cardiovascular risk
* endothelial progenitor cells
* immunosenescence
* systemic lupus erythematosus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658008
}}
{{medline-entry
|title=Emergence of T cell immunosenescence in diabetic chronic kidney disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088331


==Multifaceted role of extracellular vesicles in atherosclerosis.==
===Abstract===
Extracellular vesicles (EVs) are small vesicles released by the majority of cells in response to cell activation or death stimuli. They are grouped as small EVs or exosomes, large EVs such as microvesicles (MVs) and apoptotic bodies, resulting from distinct mechanisms of generation. EVs are released into the extracellular space, in most human biological fluids and tissues, including atherosclerotic plaques. They transport complex cargo of bioactive molecules, including proteins, lipids and genetic material and are therefore involved in pathophysiological pathways of cell-cell communication. Indeed, EVs are involved in several processes such as inflammation, coagulation, vascular dysfunction, angiogenesis and senescence, contributing to the initiation and progression of atherothrombotic diseases. Consequently, they behave as a determinant of atherosclerotic plaque vulnerability leading to major cardiovascular disorders. Over the last decade, the field of EVs research has grown, highlighting their involvement in atherosclerosis. However, limitations in both detection methodologies and standardisation have hindered implementation of EVs in the clinical settings. This review summarizes the effect of EVs in atherosclerosis development, progression and severity, with specific attention devoted to their ambivalent roles in senescence and hemostasis. This review will also highlight the role of MVs as multifaceted messengers, able to promote or to attenuate atherosclerosis progression. Finally, we will discuss the main technical challenges and prerequisites of standardization for driving EVs to the clinics and delineate their relevance as emergent biomarkers and innovative therapeutic approaches in atherosclerosis.


===MeSH Terms===
|keywords=* BMI
-
* CKD
* Diabetes
* Immunosenescence
* T cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574244
}}
{{medline-entry
|title=The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068732


===Keywords===
Atherosclerosis; Biomarkers; Extracellular vesicles; Hemostasis; Senescence


==The association between prenatal exposure to thallium and shortened telomere length of newborns.==
|keywords=* CD4/CD8 ratio
===Abstract===
* Chlamydia pneumoniae
Thallium is a widely known toxic heavy metal that has been reported have embryo toxicity. We aimed to investigate the relationship of prenatal thallium exposure with neonatal telomere length. A total of 746 mother-newborn pairs were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. Maternal thallium exposure levels were measured in spot urine samples collected during the three trimesters and during hospital delivery using inductively coupled plasma mass spectrometry. Neonatal relative telomere length (rTL) was measured by a real-time quantitative polymerase chain reaction assay in cord blood. Multiple informant models were used to evaluate the association of maternal thallium exposure with neonatal rTL. After adjustment for multiple potential confounders, each 25% incremental increase of maternal thallium exposure, measured in urine samples collected during hospital delivery, was associated with a 1.85% shortened neonatal rTL (95% CI: -3.62%, -0.05%; P = 0.044). Similarly, mothers in the highest quartile of urinary thallium exposure had a 11.74% (95% CI: -21.57%, -0.68%; P = 0.038) shorter cord blood leukocyte rTL than those in the lowest quartile. However, no significant association was found between neonatal rTL and maternal thallium exposure measured in urine samples collected during the three trimesters of pregnancy. This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.
* Immune profile
* Immunosenescence
* Lymphocyte subsets
|full-text-url=https://sci-hub.do/10.1016/j.micpath.2020.104541
}}
{{medline-entry
|title=Next steps in mechanisms of inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32960694


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Biological aging; Cord blood; Telomere length; Thallium
* autophagy
* glutathione
* membrane potential
* mitochondria
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1822089
}}
{{medline-entry
|title=A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32941476


==[i]FOXO3[/i] longevity genotype mitigates the increased mortality risk in men with a cardiometabolic disease.==
|mesh-terms=* Adult
===Abstract===
* Anti-HIV Agents
[i]FOXO3[/i] is a prominent longevity gene. To date, no-one has examined whether longevity-associated [i]FOXO3[/i] genetic variants protect against mortality in all individuals, or only in those with aging-related diseases. We therefore tested longevity-associated [i]FOXO3[/i] single nucleotide polymorphisms in a haplotype block for association with mortality in 3,584 elderly American men of Japanese ancestry, 2,512 with and 1,072 without a cardiometabolic disease (CMD). At baseline (1991-1993), 1,010 CMD subjects had diabetes, 1,919 had hypertension, and 738 had coronary heart disease (CHD). Follow-up until Dec 31, 2019 found that in CMD-affected individuals, longevity-associated alleles of [i]FOXO3[/i] were associated with significantly longer lifespan: haplotype hazard ratio 0.81 (95% CI 0.72-0.91; diabetes 0.77, hypertension 0.82, CHD 0.83). Overall, men with a CMD had higher mortality than men without a CMD ([i]P[/i]=6x10 ). However, those men with a CMD who had the [i]FOXO3[/i] longevity genotype had similar survival as men without a CMD. In men without a CMD there was no association of longevity-associated alleles of [i]FOXO3[/i] with lifespan. Our study provides novel insights into the basis for the long-established role of [i]FOXO3[/i] as a longevity gene. We suggest that the [i]FOXO3[/i] longevity genotype increases lifespan only in at-risk individuals by protection against cardiometabolic stress.
* Anticholesteremic Agents
* Atorvastatin
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Female
* HIV Infections
* HIV Protease Inhibitors
* Humans
* Immunosenescence
* Inflammation
* Lymphocyte Activation
* Male
* Middle Aged
* Pilot Projects
* Raltegravir Potassium


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498036
-
}}
{{medline-entry
|title=Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32663414


===Keywords===
FOXO3; genetics; longevity; mortality; resilience


==Identification of genes associated with endometrial cell aging.==
|keywords=* Periodontal ligament stem cells
===Abstract===
* T lymphocytes
Aging of the uterine endometrium is a critical factor that affects reproductive success, but the mechanisms associated with uterine aging are unclear. In this study, we conducted a qualitative examination of age-related changes in endometrial tissues and identified candidate genes as markers for uterine aging. Gene expression patterns were assessed by two RNA sequencing experiments using uterine tissues from wild type (WT) C57BL/6 mice. Gene expression data obtained by RNA-sequencing were validated by real-time PCR. Genes expressing the pro-inflammatory cytokines Il17rb and chemokines Cxcl12 and Cxcl14 showed differential expression between aged WT mice and a group of mice composed of 5 and 8 week-old WT (young) animals. Protein expression levels of the above-mentioned genes and of IL8, which functions downstream of IL17RB, were analysed by quantitative immunohistochemistry of unaffected human endometrium tissue samples from patients in their 20 s and 40 s (10 cases each). In the secretory phase samples, 3,3'- diaminobenzidine (DAB) staining intensities of IL17RB, CXCL12 and CXCL14 for patients in their 40 s were significantly higher than that for patients in their 20 s, as detected by a Mann Whitney U test. These results suggest that these genes are candidate markers for endometrial aging and for prediction of age-related infertility, although confirmation of these findings is needed in larger studies involving fertile and infertile women.
* age
* coculture
* cytokines
* immunophenotyping
* immunosenescence
* immunosuppression
* peripheral blood mononuclear cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364836
}}
{{medline-entry
|title=Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477103


===MeSH Terms===
-


===Keywords===
|keywords=* Liuwei Dihuang decoction
CXCL12; CXCL14; IL17RB; endometrial cell aging; infertility; quantitative
* aging
immunohistochemistry
* cognition
* immune response
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241684
}}
{{medline-entry
|title=Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32280463


==Cognitive decline negatively impacts physical function.==
===Abstract===
Many older adults report difficulty performing one or more activities of daily living. These difficulties may be attributed to cognitive decline and as a result, measuring cognitive status among aging adults may help provide an understanding of current functional status. The purpose of the present investigation was to determine the association between cognitive status and measures of physical functioning. Seventy-six older adults participated in this study; 41 were categorized as normal memory function (NM) and 35 were poor memory function (PM). NM participants had significantly higher physical function as measured by Short Physical Performance Battery (SPPB; 9.4 ± 2.2 vs. 8.4 ± 2.0; p = .03) and peak velocity (0.67 ± 0.16 vs. 0.56 ± 0.19; p = .04) during a quick sit-to-stand task. Dual-task walking velocities were 22% and 126% slower between cognitive groups for the fast and habitual trials, respectively when compared to the single-task walking condition. Significant correlations existed between measures of memory and physical function. The largest correlations with memory were for peak (r = 0.42) and average (r = 0.38) velocity. The results suggest a positive relationship between physical function and cognitive status. However, further research is needed to determine the mechanism of the underlying relationships between physical and cognitive function.


===MeSH Terms===
|keywords=* CD28− T cells
-
* HaploSCT
* immune monitoring
* immunosenescence
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142179
}}
{{medline-entry
|title=Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32209361


===Keywords===
Aging; Cognition, movement velocity, dual-task, memory; Physical function


==Changes in self-estimated step-over ability among older adults: A 3-year follow-up study.==
|keywords=* Biological aging
===Abstract===
* Cytomegalovirus
There is a growing body of literature examining age-related overestimation of one's own physical ability, which is a potential risk of falls in older adults, but it is unclear what leads them to overestimate. This study aimed to examine 3-year longitudinal changes in self-estimated step-over ability, along with one key risk factor: low frequency of going outdoors (FG), which is a measure of poor daily physical activity. This cohort study included 116 community-dwelling older adults who participated in baseline and 3-year follow-up assessments. The step-over test was used to measure both the self-estimated step-over bar height (EH) and the actual bar height (AH). Low FG was defined as going outdoors either every few days or less at baseline. The number of participants who overestimated their step-over ability (EH>AH) significantly increased from 10.3% to 22.4% over the study period. AH was significantly lower at follow-up than at baseline in both participants with low and high FGs. Conversely, among participants with low FG, EH was significantly higher at follow-up than at baseline, resulting in increased self-estimation error toward overestimation. Regression model showed that low FG was independently associated with increased error in estimation (i.e., tendency to overestimate) at follow-up. The present study indicated that self-overestimated physical ability in older adults is not only due to decreased physical ability but also due to increased self-estimation of one's ability as a function of low FG. Active lifestyle may be critical for maintaining accurate estimations of one's own physical ability.
* Depression
* Immunosenescence
* Major depressive disorder
* Sex differences
* T-cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594105
}}
{{medline-entry
|title=Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32190092


===MeSH Terms===
-


===Keywords===
|keywords=* Ageing
Aging; Inactive lifestyle; Judgment; Self-assessment; Step over
* Cell senescence
* Cognitive impairment
* Immune ageing
* Rheumatoid arthritis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068869
}}
{{medline-entry
|title=Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107852


==Improvements of Disability Outcomes in CAPABLE Older Adults Differ by Financial Strain Status.==
===Abstract===
The Community Aging in Place-Advancing Better Living for Elders (CAPABLE) program reduces disability in low-income older adults. In this study, we used CAPABLE baseline and 5-month data to examine whether its effects in reducing activities of daily living (ADLs) and instrumental ADLs (IADLs) difficulties differed by participants' financial strain status. At baseline, participants with financial strain were more likely to report higher scores on depression ([i]p[/i] < .001), have low energy ([i]p[/i] < .001), and usually feel tired ([i]p[/i] = .004) compared with participants without financial strain, but did not differ in ADL/IADL scores. Participants with financial strain benefited from the program in reducing ADL (relative risk [RR]: 0.61, 95% confidence interval [CI]: 0.43, 0.86) and IADL disabilities (RR: 0.69, 95% CI: 0.54, 0.87), compared with those with financial strain receiving attention control. Individuals with financial strain benefited more from a home-based intervention on measures of disability than those without financial strain. Interventions that improve disability may be beneficial for financially strained older adults.


===MeSH Terms===
|keywords=* immunosenescence
-
* lupus-associated brain fog
* systemic lupus erythematosus
|full-text-url=https://sci-hub.do/10.1111/1756-185X.13816
}}
{{medline-entry
|title=T cells, aging and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32092501


===Keywords===
aging; health disparity; intervention; physical function


==Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).==
|keywords=* Aging
===Abstract===
* Senescence
Chrysomya albiceps (Wiedemann 1819) is one of the most important insects in forensic entomology. Its larval developmental and survival rates are influenced by nutritional resources, temperature, humidity, and geographical regions. The present study investigated the possibility of relying on body size and cuticular hydrocarbon composition as indicators for age estimation of the different larval instars of C. albiceps. Larvae were maintained in standardized laboratory conditions at different experimental temperatures. All larval instars (first, second, and third) were randomly collected for measuring their body sizes and for estimating their cuticular hydrocarbons at different rearing temperatures (30, 35, 40, and 45°C) using gas chromatography-mass spectrometry (GC-MS). Results indicated that the duration of larval stage was temperature dependent as it gradually decreased on increasing the rearing temperature (30, 35, and 40°C) except 45°C at which larval development was ceased. In contrary, larval body size, in terms of length, width, and weight, was temperature dependent as it gradually increased with larval development on increasing rearing temperature except at 45°C at which larval development was ceased. The GC-MS showed a significant difference in the extracted components of cuticular hydrocarbons between different larval instars reared in the same temperature and between the same larval instar that reared at different temperatures. Furthermore, the highest and lowest amounts of cuticular hydrocarbons were detected at 35 and 40°C, respectively. Overall, larval body size and cuticular hydrocarbon components were temperature dependent within the range 30-40°C, which may suggest them as possible reliable age indicators for estimating the postmortem interval in the field of medicolegal entomology.
* T cells
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110887
}}
{{medline-entry
|title=Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31892306


===MeSH Terms===
|mesh-terms=* Adult
-
* Alcoholism
* CD28 Antigens
* CD4-Positive T-Lymphocytes
* CD57 Antigens
* CD8-Positive T-Lymphocytes
* Cross-Sectional Studies
* Female
* HIV Infections
* Hepatitis C
* Humans
* Immunologic Memory
* Immunosenescence
* Leukocyte Common Antigens
* Linear Models
* Liver Cirrhosis, Alcoholic
* Male
* Phenotype
* Randomized Controlled Trials as Topic
* Russia
* Zinc
|keywords=* Alcohol
* HIV
* Immune senescence
* Liver fibrosis
* Russia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938606
}}
{{medline-entry
|title=Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31895587


===Keywords===


          Chrysomya albiceps
|keywords=* aging
        ; body size; cuticular hydrocarbon; forensic; larval longevity
* cellular senescence
* memory T cells
* stem cell
|full-text-url=https://sci-hub.do/10.1089/cell.2019.0055
}}
{{medline-entry
|title=Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31462901


==Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal.==
===Abstract===
Changes in stem cell activity may underpin aging. However, these changes are not completely understood. Here, we combined single-cell profiling with machine learning and in vivo functional studies to explore how hematopoietic stem cell (HSC) divisions patterns evolve with age. We first trained an artificial neural network (ANN) to accurately identify cell types in the hematopoietic hierarchy and predict their age from single-cell gene-expression patterns. We then used this ANN to compare identities of daughter cells immediately after HSC divisions and found that the self-renewal ability of individual HSCs declines with age. Furthermore, while HSC cell divisions are deterministic and intrinsically regulated in young and old age, they are variable and niche sensitive in mid-life. These results indicate that the balance between intrinsic and extrinsic regulation of stem cell activity alters substantially with age and help explain why stem cell numbers increase through life, yet regenerative potency declines.


===MeSH Terms===
|keywords=* Aging
-
* Antibodies
* B cells
* Bone marrow
* Exhaustion
* Immunosenescence
* Inflammation
* Pro-inflammatory
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706884
}}
==CD33==


===Keywords===
{{medline-entry
aging; artificial neural network; hematopoietic stem cell; machine learning; self-renewal
|title=Maximum reproductive lifespan correlates with [[CD33]]rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907986


==Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.==
|mesh-terms=* Animals
===Abstract===
* Gene Dosage
The ability to distinguish resident microglia from infiltrating myeloid cells by flow cytometry-based surface phenotyping is an important technique for examining age-related neuroinflammation. The most commonly used surface markers for the identification of microglia include CD45 (low-intermediate expression), CD11b, Tmem119, and P2RY12. In this study, we examined changes in expression levels of these putative microglia markers in in vivo animal models of stroke, cerebral amyloid angiopathy (CAA), and aging as well as in an ex vivo LPS-induced inflammation model. We demonstrate that Tmem119 and P2RY12 expression is evident within both CD45  and CD45  myeloid populations in models of stroke, CAA, and aging. Interestingly, LPS stimulation of FACS-sorted adult microglia suggested that these brain-resident myeloid cells can upregulate CD45 and downregulate Tmem119 and P2RY12, making them indistinguishable from peripherally derived myeloid populations. Importantly, our findings show that these changes in the molecular signatures of microglia can occur without a contribution from the other brain-resident or peripherally sourced immune cells. We recommend future studies approach microglia identification by flow cytometry with caution, particularly in the absence of the use of a combination of markers validated for the specific neuroinflammation model of interest. The subpopulation of resident microglia residing within the "infiltrating myeloid" population, albeit small, may be functionally important in maintaining immune vigilance in the brain thus should not be overlooked in neuroimmunological studies.
* Humans
* Longevity
* NADPH Oxidases
* Neutrophils
* Reactive Oxygen Species
* Sialic Acid Binding Ig-like Lectin 3
* Whale, Killer
|keywords=*
CD33rSIGLEC


===MeSH Terms===
* NADPH-oxidase
-
* prolonged post-reproductive lifespan
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018541
}}
==CD34==


===Keywords===
{{medline-entry
Aging; Brain infiltrating myeloid cells; CD45; Cerebral amyloid angiopathy; Microglia; Neuroinflammation; P2RY12; Stroke; Tmem119
|title=Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271899


==Laying the foundation for an International Classification of Functioning, Disability and Health Core Set for community-dwelling elderly adults in primary care: the clinical perspective identified in a cross-sectional study.==
===Abstract===
Having more information about the biopsychosocial functioning of their geriatric patients might help physicians better balance medical interventions according to patients' needs. For this reason, we aimed to develop an easy-to-handle International Classification of Functioning, Disability and Health (ICF) Core Set for community-dwelling geriatric patients aged 75 and older in primary care. In this empirical study, we describe the functioning and health of community-dwelling patients aged 75 and older in primary care in Germany and identify the most common problems encountered by these individuals when using the ICF. In this exploratory, cross-sectional study, a health professional conducted semi-structured interviews. Community-dwelling older adults aged 75 and older in Germany. 65 participants (mean age=80.2, SD=3.6). Extended ICF Checklist V.2.1a, patients prioritised chapters of the 'activities and participation' component. The three most common impairments for 'body functions' were [i]visual system functions[/i] (ICF-code [i]b210[/i]; 89%), [i]blood pressure functions[/i] ([i]b420[/i]; 80%) and [i]sensations associated with hearing and vestibular functions[/i] ([i]b240; 59%[/i]). For 'body structures', they were [i]eyes, ears and related structures[/i] ([i]s2[/i]; 81%), [i]structure of mouth[/i] ([i]s320[/i]; 74%) and [i]structures related to the digestive, metabolic and endocrine systems[/i] ([i]s5[/i]; 49%). For the 'activities and participation' component, adequate aids compensated for activity limitations to a certain degree. Still, after having adequate aids, the category in which the participants had the most difficulty was [i]walking[/i] ([i]d450;[/i] 35%). Participants rated the 'mobility' chapter as the most important of all chapters. 'Environmental factors' were facilitators of participants' functioning. This empirical study provides a list of ICF categories relevant to older adults from the clinical perspective. Along with lists from the other three preparatory studies, it will form the basis for the development of an ICF Core Set for community-dwelling older adults in primary care. The trial is registered in ClinicalTrials.gov (NCT03384732).


===MeSH Terms===
|keywords=* SUSD2
-
* adipose tissue
* apoptosis
* bone marrow
* clonogenicity
* endometrium
* menstrual fluid
* perivascular mesenchymal stromal cells
* placenta
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712261
}}
{{medline-entry
|title=ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247425


===Keywords===
ICF; aging; community-dwelling older people; core set; functioning; general practice


==Histone Variant H2A.J Marks Persistent DNA Damage and Triggers the Secretory Phenotype in Radiation-Induced Senescence.==
|keywords=* ACE2
===Abstract===
* Aging
Irreparable double-strand breaks (DSBs) in response to ionizing radiation (IR) trigger prolonged DNA damage response (DDR) and induce premature senescence. Profound chromatin reorganization with formation of senescence-associated heterochromatin foci (SAHF) is an essential epigenetic mechanism for controlling the senescence-associated secretory phenotype (SASP). To decipher molecular mechanisms provoking continuous DDR leading to premature senescence, radiation-induced DSBs (53BP1-foci) and dynamics of histone variant H2A.J incorporation were analyzed together with chromatin re-modeling in human fibroblasts after IR exposure. High-resolution imaging by transmission electron microscopy revealed that persisting 53BP1-foci developed into DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS), consistently located at the periphery of SAHFs. Quantitative immunogold-analysis by electron microscopy revealed that H2A.J, steadily co-localizing with 53BP1, is increasingly incorporated into DNA-SCARS during senescence progression. Strikingly, shRNA-mediated H2A.J depletion in fibroblasts modified senescence-associated chromatin re-structuring and abolished SASP, thereby shutting down the production of inflammatory mediators. These findings provide mechanistic insights into biological phenomena of SASP and suggest that H2A.J inhibition could ablate SASP, without affecting the senescence-associated growth arrest.
* Angiotensin-(1-7)
* Hematopoietic stem/progenitor cells
* Ischemia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694587
}}
{{medline-entry
|title=Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood [[CD34]]  Cells in Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32841054


===MeSH Terms===
-


===Keywords===
|keywords=* CD34+ cells
DNA-SCARS; histone variant H2A.J; radiation-induced senescence; senescence-associated heterochromatin foci (SAHF); senescence-associated secretory phenotype (SASP); transmission electron microscopy (TEM)
* aging
* day easy exercise
* mind–body intervention
|full-text-url=https://sci-hub.do/10.1177/0963689720952352
}}
{{medline-entry
|title=Human Thymic Involution and Aging in Humanized Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32733465


==TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.==
===Abstract===
In the current study, we aimed to explore the correlation between TRIM27 and breast cancer prognosis, as well as the functions of TRIM27 in breast cancer and their underlying mechanisms. Bioinformatics analyses were used to examine the correlation between TRIM27 and breast cancer prognosis. Moreover, TRIM27 knockdown and overexpression in breast cancer cells were performed to investigate its functions in breast cancer. Tamoxifen (TAM) was applied to evaluate the influence of TRIM27 on chemoresistance of breast cancer cells, while co-immunoprecipitation (coIP) was performed to identify the E3 ubiquitin ligase capability of TRIM27. High expression of TRIM27 was found in non-triple-negative breast cancer (non-TNBC) tumor tissues and was positively correlated with the mortality of non-TNBC patients. Moreover, TRIM27 could suppress non-TNBC cell apoptosis and senescence, promote cell viability and tumor growth, counteract the anti-cancer effects of TAM, and mediate ubiquitination of p21. In addition, EP300 could enhance the expression of TRIM27 and its transcription promoter H3K27ac. TRIM27, through ubiquitination of p21, might serve as a prognostic biomarker for non-TNBC prognosis. TRIM27 functions as a novel oncogene in non-TNBC cellular processes, especially suppressing cell senescence and interfering with non-TNBC chemoresistance.


===MeSH Terms===
|keywords=* aging
-
* human
* humanized mouse
* recent thymic emigrants
* thymus involution
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358581
}}
{{medline-entry
|title=Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood [[CD34]]  cells via inhibition of senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32602209


===Keywords===
EP300; TRIM27; breast cancer; cell apoptosis; cell senescence; chemoresistance; p21; prognosis; transcription; ubiquitination


==The Effect of Chronic Diseases on the Use of Health Technology and Digital Services in the Elderly Population in Finland.==
|keywords=* HSC stemness maintenance
===Abstract===
* Stem Regenin 1
Digital services are growing in the health-care field. The population in Europe is aging, and digital services are on the rise. There are also plenty of new health-care devices on the market. The aim of this study was to survey how elderly people cope with digital services or devices, especially if they are chronically ill. This quantitative study focuses on the impact of chronic diseases on the use of health technology and digital services. The target group of this study is Finnish people aged 65 or over. Based on the results, a chronic disease or disability is not an obstacle to the use of digital services or health-care technology in the Finnish elderly population. The main obstacles to the use of health technology or digital services are complexity, obscure text, or small font size. According to this study, elderly people seem to trust the device or application. Devices, applications, and online services should be designed so that elderly people's diseases or ability to function are considered.
* cellular senescence
* ex vivo expansion
* human cord blood CD34+ cells
* mammalian target of rapamycin complex 1
* p38 mitogen-activated protein kinase α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695631
}}
{{medline-entry
|title=Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531351


===MeSH Terms===
|mesh-terms=* Age Factors
Aged
* Aged
* Aged, 80 and over
* Aging
* Aging
* Biomedical Technology
* Choroid
* Chronic Disease
* Endothelial Cells
* Europe
* Female
* Finland
* Gene Expression Regulation
* Humans
* Humans
* Infant
* Infant, Newborn
* Inflammation
* Inflammation Mediators
* Macular Degeneration
* Male
* Middle Aged
* Phenotype
* Sequence Analysis, RNA
* Single-Cell Analysis
|keywords=* Age-related macular degeneration
* Choriocapillaris
* Choroid
* Infant
* Pericytes
* Single-cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396301
}}
{{medline-entry
|title=Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32432372


===Keywords===
Digital services; Disease; Health care; Health technology


==Aging Narratives over 210 years (1810-2019).==
|keywords=* aging
===Abstract===
* autophagy
The World Health Organization launched a recent global campaign to combat ageism, citing its ubiquity and insidious threat to health. The historical context that promoted this pernicious threat is understudied, and such studies lay the critical foundation for designing societal-level campaigns to combat it. We analyzed the trend and content of aging narratives over 210 years across multiple genres-newspaper, magazines, fiction, non-fiction books; and modelled the predictors of the observed trend. A 600-million-word-dataset was created from the Corpus-of-Historical-American-English and the Corpus-of-Contemporary-American-English to form the largest structured historical corpus with over 150,000 texts from multiple genres. Computational linguistics and statistical techniques were applied to study the trend, content, and predictors of aging narratives. Aging narratives have become more negative, in a linear fashion (p=.003), over 210 years. There are distinct shifts: From uplifting narratives of heroism and kinship in the 1800s to darker tones of illness, death, and burden in the 1900s across newspapers, magazines, and non-fiction books. Fiction defied this trend by portraying older adults positively through romantic courtship and war heroism. Significant predictors of ageism over 210 years are the medicalization of aging, loss of status, warmth, competence, and social ostracism. Though it is unrealistic to reverse the course of ageism, its declining trajectory can be ameliorated. Our unprecedented study lay the groundwork for a societal level campaign to tackle ageism. The need to act is more pressing given the Covid-19 pandemic where older adults are constantly portrayed as vulnerable.
* bone marrow injury
* mesenchymal stem cells
* repair
|full-text-url=https://sci-hub.do/10.1002/cbf.3548
}}
{{medline-entry
|title=Immune cell extracellular vesicles and their mitochondrial content decline with ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31911808


===MeSH Terms===
-


===Keywords===
|keywords=* Ageing
Ageism; age discrimination; age stereotypes; historical analysis; media portrayals of aging; medicalization of aging; psychomics; social gerontology; social ostracism
* Apoptotic bodies
* Exosomes
* Extracellular vesicles
* Immune cells
* Immunosenescence
* Inflammageing
* Microvesicles
* Mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942666
}}
{{medline-entry
|title=Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497915


==Premature CD4  T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.==
|mesh-terms=* Adult
===Abstract===
* Aged
Acquired immune responses mediated by CD4  T cells contribute to the initiation and progression of acute coronary syndrome (ACS). ACS patients show acquired immune system abnormalities that resemble the characteristics of autoimmune dysfunction described in the elderly. This study aimed to investigate the role of premature CD4  T cells senescence in ACS and the underlying mechanism. We compared the immunological status of 25 ACS patients, 15 young healthy individuals (C1), and 20 elderly individuals with absence of ACS (C2). The percentages of CD4  T lymphocyte subsets (including naïve, regulatory, memory and effector T cells) in peripheral blood were analyzed. In ACS patients, a significant expansion of CD4 CD28  effector T cells and a decline of CD4 CD25 CD62L Treg cells were observed. In addition, patients with ACS showed an accelerated loss of CD4 CD45RA CD62L  naïve T cells and a compensatory increase in the number of CD4 CD45RO  memory T cells. ACS patients demonstrated no significant difference in frequency of T cell receptor excision circles (TRECs) compared to age-matched healthy volunteers. The expression of p16  was increased while CD62L was decreased in CD4 CD28  T cells of ACS patients. Compared to healthy donors, ACS patients demonstrated the lowest telomerase activity in both CD4 CD28 and CD4 CD28  T cells. The serum levels of C-reactive protein, Cytomegalovirus IgG, [i]Helicobactor pylori[/i] IgG and [i]Chlamydia pneumonia[/i] IgG were significantly higher in ACS patients. The results suggested that the percentage of CD4  T cell subpopulations correlated with chronic infection, which contributes to immunosenescence. In conclusion, chronic infection induced senescence of premature CD4 T cells, which may be responsible for the development of ACS.
* Aged, 80 and over
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Carcinoma, Squamous Cell
* Female
* Humans
* Immunohistochemistry
* Immunosenescence
* Macrophages
* Male
* Middle Aged
* Mouth Neoplasms
* Neovascularization, Pathologic
* Receptors, Cell Surface
* Tumor Microenvironment
|keywords=* M1 and M2 macrophages
* angiogenesis
* immunohistochemistry
* immunosenescence
* oral squamous cell carcinoma
|full-text-url=https://sci-hub.do/10.1002/hed.25954
}}
==CD36==


===MeSH Terms===
{{medline-entry
-
|title=Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32638492


===Keywords===
CD28null T cells; CD4+ T cells; acute coronary syndrome; immunosenescence; infection


==Autoantibodies specific for C1q, C3b, β2-glycoprotein 1 and annexins may amplify complement activity and reduce apoptosis-mediated immune suppression.==
|keywords=* Osteopontin
===Abstract===
* aging
Neoplastic cells hijack cell death pathways to evade the immune response. Phosphatidylserine, a marker of apoptotic cells, and its highly conserved bridging proteins, annexins and β2-glycoprotein I, facilitate the efficient removal of apoptotic and necrotic cells via tumor-associated phagocytes in a process called efferocytosis. Efferocytosis results in the clearance of dead and dying cells and local immune suppression. Neoplastic cells also have an increased capacity to activate complement. Complement may facilitate the silent removal of tumor cells and has a dual role in promoting and inhibiting tumor growth. Here I hypothesize that immune response-generating IgG autoantibodies that recognize opsonizing fragments C1q, C3b, and phosphatidylserine-binding proteins (annexins, β2-glycoprotein I) may reduce tumor growth. I propose that these autoantibodies induce a pro-inflammatory, cytotoxic tumor microenvironment. Further, I predict that autoantibodies can drive neoplastic cell phagocytosis in an Fc receptor-dependent manner and recruit additional complement, resulting in immune-stimulatory effects. Excessive complement activation and antibody-dependent cytotoxicity may stimulate anti-tumor responses, including damage to tumor vasculature. Here I provide insights that may aid the development of more effective therapeutic modalities to control cancer. Such therapeutic approaches should kill neoplastic cells and target their interaction with host immune cells. Thereby the pro-tumorigenic effect of dead cancer cells could be limited while inducing the anti-tumor potential of tumor-associated phagocytes.
* lipid metabolism
* nonalcoholic fatty liver disease
* p53
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431823
}}
{{medline-entry
|title=Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32479666


===MeSH Terms===
-


===Keywords===
|keywords=* CD36 scavenger receptor
Aging; Annexin(s); Apoptosis; Autoantibody (-bodies); C1q; C3b; Cancer(s); Complement; Cytotoxicity; Efferocytosis; Immune-suppression/immunosuppression; Lymphoma(s); Necrosis; Phagocytosis; Phosphatidylserine; Tumor(s); Vasculature; b2-glycoprotein 1; b2-glycoprotein I; β2-glycoprotein 1; β2-glycoprotein I
* alpha-tocopherol
* exosomes
* extracellular vesicles
* gene expression
* lysosome
* senescence
* signal transduction
* vitamin E
|full-text-url=https://sci-hub.do/10.1002/biof.1636
}}
{{medline-entry
|title=Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030468


==Comparison study of patient demographics and risk factors for surgical site infections following open reduction and internal fixation for lateral malleolar ankle fractures within the medicare population.==
===Abstract===
The purpose of this study was to analyze a comprehensive database to 1) compare patient demographic profiles; and 2) identify patient-related risk factors for surgical site infections (SSIs) following open reduction and internal fixation (ORIF) for lateral malleolar ankle fractures. Patients treated with ORIF for lateral malleolar ankle fractures that developed SSIs within 1-year following the procedure were identified. Study group demographics were compared to a control cohort and risks for developing SSI were calculated using multivariate logistic regression analysis. There were statistically significant differences between the control group and patients with SSIs. The study showed that morbidly obese patients, peripheral vascular disease, and electrolyte/fluid imbalance were the greatest risk factors for developing SSIs following ORIF for lateral malleolar fractures. The study is useful as it can allow orthopaedists to optimize these high-risk patients to potentially mitigate this adverse event.


===MeSH Terms===
|keywords=* Aging
-
* Macrophages
* Microglia
* Oligodendrocyte progenitor cells
* Phagocytosis
* Remyelination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181452
}}
==CD38==


===Keywords===
{{medline-entry
Geriatrics; Lateral malleolar ankle fracture; Medicare; Outcomes; Risk factors; Surgical site infections
|title=Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32935380


==Rapamycin Eyedrops Increased CD4 Foxp3  Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.==
===Abstract===
Dry eye disease (DED), one of the most prevalent conditions among the elderly, is a chronic inflammatory disorder that disrupts tear film stability and causes ocular surface damage. Aged C57BL/6J mice spontaneously develop DED. Rapamycin is a potent immunosuppressant that prolongs the lifespan of several species. Here, we compared the effects of daily instillation of eyedrops containing rapamycin or empty micelles for three months on the aged mice. Tear cytokine/chemokine profile showed a pronounced increase in vascular endothelial cell growth factor-A (VEGF-A) and a trend towards decreased concentration of Interferon gamma (IFN)-γ in rapamycin-treated groups. A significant decrease in inflammatory markers in the lacrimal gland was also evident ([i]IFN-γ[/i], [i]IL-12[/i], [i]CIITA[/i] and [i]Ctss[/i]); this was accompanied by slightly diminished [i]Unc-51 Like Autophagy Activating Kinase 1[/i] ([i]ULK1[/i]) transcripts. In the lacrimal gland and draining lymph nodes, we also observed a significant increase in the CD45 CD4 Foxp3  cells in the rapamycin-treated mice. More importantly, rapamycin eyedrops increased conjunctival goblet cell density and area compared to the empty micelles. Taken together, evidence from these studies indicates that topical rapamycin has therapeutic efficacy for age-associated ocular surface inflammation and goblet cell loss and opens the venue for new investigations on its role in the aging process of the eye.


===MeSH Terms===
|keywords=* CD38 NADase
-
* NAD metabolism
* mitochondrial impairment
* replicative senescence
* telomere biology disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604620
}}
{{medline-entry
|title=TNFRSF12A and [[CD38]] Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32537452


===Keywords===
aging; dry eye; goblet cell; inflammation; lacrimal gland; ocular surface; rapamycin


==A CTSA-based consultation service to advance research on special and underserved populations.==
|keywords=* aging
===Abstract===
* chronic inflammation
In this report, we describe the implementation and short-term outcomes of a Special Populations Consultation Service within the University of California, Los Angeles (UCLA) Clinical and Translational Science Institute (CTSI). With the goal of increasing the quality and quantity of special population (SP) research, the UCLA CTSI Integrating Special Populations program designed a consultation service to support faculty and trainees conducting research involving one of three CTSI "special populations:" children, older adults, and/or minority; underserved; or health disparity populations. The Special Populations Consultation Service offers three types of activities: grant proposal studios, career consultations, and project reviews. UCLA CTSI faculty with appropriate content expertise serve as consultants. We evaluated this consultation model using satisfaction surveys and by quantifying funded grants and reported changes in career goals in SP research. Between 2016 and 2019, the Special Populations Consultation Service provided 59 consultations including 42 grant studios and was used by researchers at all levels from all four UCLA CTSI institutions. Recipients rated the consultations very highly. Funding success rates were 57% following K-level grant studios and 28% following R-level grant studios. Users of project and career consultations commonly attributed career accomplishments in part to their consultation experiences. The SP Consultation Service is feasible and acceptable and appears to enhance careers of investigators studying special populations.
* lung
* network analysis
* senescence
* tissue remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268922
}}
{{medline-entry
|title=Aging alters acetylation status in skeletal and cardiac muscles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32300965


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
faculty development; geriatrics; grant review; grant studio; pediatrics; peer review; research consultation service; special populations; underrepresented minorities
* CD38
* Deacetylation
* NAD+
* PARP
* SIRT
* Skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286993
}}
{{medline-entry
|title=[[CD38]] in Neurodegeneration and Neuroinflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32085567


==Age relationships with telomere length, body weight and body length in wild dugong ([i]Dugong dugon[/i]).==
===Abstract===
The ability to estimate age and determine the growth status of free-ranging dugongs ([i]Dugong dugon[/i]) is vital to providing insight into the basic biology of this endangered species. Currently, age estimation in dugong carcasses relies on counting dentin growth layer groups (GLGs) in tusks, but a disadvantage is they need to be intact. We explored whether measures of telomere length could be used as an alternative approach to age estimation in dugongs given that in other species, telomere length and age are inversely related. In this study, relative telomere length (rTL) was measured by qPCR in skin samples from 24 dugongs of varying ages determined by counts of GLGs. In addition, relationships between age by GLG counts and body weight and length and were examined. Our findings indicate that age estimated by GLGs was negatively correlated with telomere length using the logistic formula with a rate of telomere attrition of approximately 0.036 rTL/year between the ages of 5-20 years. By comparison, both body weight and length were positively correlated with GLG-based age, with growth rates of ~8.8 kg/year for weight and ~3.58 cm/year for length, respectively. After that, growth rates slowed substantially and then plateaued. The results suggest that physical maturity in dugongs occurs at 20 years of age and that measures of rTL might serve as a tool for age estimation in dugongs, living and deceased.


===MeSH Terms===
|keywords=* ALS.
-
* Alzheimer’s disease
* CD38
* NAD
* Parkinson’s disease
* aging
* neurodegeneration
* neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072759
}}
{{medline-entry
|title=[[CD38]], a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783629


===Keywords===
|mesh-terms=* ADP-ribosyl Cyclase 1
Age; Growth; Senescence; Sirenia; Telomere; Tusk
* Aging
* Animals
* Antibodies, Monoclonal
* B-Lymphocytes, Regulatory
* Cell Line
* Extracellular Vesicles
* Humans
* Infections
* Membrane Glycoproteins
* Mice
* Neoplasms
* T-Lymphocytes, Regulatory
|keywords=* CD38
* adenosine
* immune-modulation
* regulatory cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953043
}}
{{medline-entry
|title=[[CD38]] Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31551807


==Palliative and end of life care for people with advanced dementia.==
===Abstract===
Despite growing understanding in recent years of the biological, psychological, social, environmental and spiritual aspects of dementia, people with advanced dementia continue to experience inequalities in accessing healthcare capable of improving their lives. The complexities of advanced dementia challenge professional competence and demand the highest level of skilled, compassionate care. This article, the last in a series on living with advanced dementia, considers the status and direction of palliative care as it applies to people with dementia and explores contemporary issues regarding advanced dementia and end of life, with a focus on guidance for practitioners and support for best practice. It identifies that open communication, clear information and a person-centred approach adopted as early as possible in the syndrome can make this period less distressing. Crucially, people at the end of life should be offered care in line with best practice in palliative and end of life approaches.


===MeSH Terms===
|keywords=* CD38
-
* D-galactose
* NAD+
* heart senescence
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735286
}}
==CD4==


===Keywords===
{{medline-entry
advanced dementia; clinical; dementia; end of life care; gerontology; neurology; older people; palliative care
|title=Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304387


==Statin Treatment in Specific Patient Groups: Role for Improved Cardiovascular Risk Markers.==
===Abstract===
Ample evidence supports the use of statin therapy for secondary prevention in patients with a history of atherosclerotic cardiovascular disease (ASCVD), but evidence is wanting in the case of primary prevention, low-risk individuals, and elderly adults 65+. Statins are effective in lowering low-density lipoprotein (LDL), which has long been a target for treatment decisions. We discuss the weakening dependence between cholesterol levels and mortality as a function of age and highlight recent findings on lipoprotein subfractions and other superior markers of ASCVD risk. The efficacy of statins is compared for distinct subsets of patients based on age, diabetes, ASCVD, and coronary artery calcium (CAC) status. Most cardiovascular risk calculators heavily weight age and overestimate one's absolute risk of ASCVD, particularly in very old adults. Improvements in risk assessment enable the identification of specific patient populations that benefit most from statin treatment. Derisking is particularly important for adults over 75, in whom treatment benefits are reduced and adverse musculoskeletal effects are amplified. The CAC score stratifies the benefit effect size obtainable with statins, and forms of coenzyme Q are discussed for improving patient outcomes. Robust risk estimator tools and personalized, evidence-based approaches are needed to optimally reduce cardiovascular events and mortality rates through administration of cholesterol-lowering medications.


===MeSH Terms===
|keywords=* GEO database
-
* bioinformatics
* biomarker
* immune cell infiltration
* ovarian aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701310
}}
{{medline-entry
|title=Distinct Age-Related Epigenetic Signatures in [[CD4]] and CD8 T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262764


===Keywords===
cardiovascular disease; cardiovascular risk calculators; coenzyme Q; coronary artery calcification; geriatrics; lipoprotein subfractions; low-density lipoprotein cholesterol; primary prevention; risk biomarkers; statins


==The hypothalamic-pituitary-gonadal axis controls muscle stem cell senescence through autophagosome clearance.==
|keywords=* T-cell
===Abstract===
* T-cell homeostasis
With organismal aging, the hypothalamic-pituitary-gonadal (HPG) activity gradually decreases, resulting in the systemic functional declines of the target tissues including skeletal muscles. Although the HPG axis plays an important role in health span, how the HPG axis systemically prevents functional aging is largely unknown. We generated muscle stem cell (MuSC)-specific androgen receptor (Ar) and oestrogen receptor 2 (Esr2) double knockout (dKO) mice and pharmacologically inhibited (Antide) the HPG axis to mimic decreased serum levels of sex steroid hormones in aged mice. After short-term and long-term sex hormone signalling ablation, the MuSCs were functionally analysed, and their aging phenotypes were compared with those of geriatric mice (30-month-old). To investigate pathways associated with sex hormone signalling disruption, RNA sequencing and bioinformatic analyses were performed. Disrupting the HPG axis results in impaired muscle regeneration [wild-type (WT) vs. dKO, P < 0.0001; Veh vs. Antide, P = 0.004]. The expression of DNA damage marker (in WT = 7.0 ± 1.6%, dKO = 32.5 ± 2.6%, P < 0.01; in Veh = 13.4 ± 4.5%, Antide = 29.7 ± 5.5%, P = 0.028) and senescence-associated β-galactosidase activity (in WT = 3.8 ± 1.2%, dKO = 10.3 ± 1.6%, P < 0.01; in Veh = 2.1 ± 0.4%, Antide = 9.6 ± 0.8%, P = 0.005), as well as the expression levels of senescence-associated genes, p16 and p21  , was significantly increased in the MuSCs, indicating that genetic and pharmacological inhibition of the HPG axis recapitulates the progressive aging process of MuSCs. Mechanistically, the ablation of sex hormone signalling reduced the expression of transcription factor EB (Tfeb) and Tfeb target gene in MuSCs, suggesting that sex hormones directly induce the expression of Tfeb, a master regulator of the autophagy-lysosome pathway, and consequently autophagosome clearance. Transduction of the Tfeb in naturally aged MuSCs increased muscle mass [control geriatric MuSC transplanted tibialis anterior (TA) muscle = 34.3 ± 2.9 mg, Tfeb-transducing geriatric MuSC transplanted TA muscle = 44.7 ± 6.7 mg, P = 0.015] and regenerating myofibre size [eMyHC  tdTomato  myofibre cross-section area (CSA) in control vs. Tfeb, P = 0.002] after muscle injury. Our data show that the HPG axis systemically controls autophagosome clearance in MuSCs through Tfeb and prevents MuSCs from senescence, suggesting that sustained HPG activity throughout life regulates autophagosome clearance to maintain the quiescence of MuSCs by preventing senescence until advanced age.
* aging
* chromatin accessibility
* epigenetics
* ribosomal proteins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686576
}}
{{medline-entry
|title=IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240286


===MeSH Terms===
-


===Keywords===
|keywords=* Candida
Aging; Autophagy; Cellular senescence; Muscle regeneration; Muscle stem cell; Sex steroid hormones
* Foxp3
* IL-1β
* Treg
* Treg17
* aging
* fungal infection
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677307
}}
{{medline-entry
|title=Thymus involution sets the clock of declined immunity and repair with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33248315


==Probing menstrual bloodstain aging with fluorescence spectroscopy.==
===Abstract===
Menstrual blood (MB) is a common and important type of forensic evidence, especially in sexual assault cases. MB is composed of peripheral blood (PB), vaginal fluid, and endometrial cells of the uterine wall. In forensic investigations, the differentiation of MB and PB can determine whether the blood present is a result of tissue damage from an assault or a natural cause and thus help to reconstruct the event. Understanding how menstrual blood changes is necessary to develop a method for bloodstain aging. Fluorescence spectroscopy, a promising spectroscopic method for bloodstain analysis, was used to probe the biochemical changes that occur over time in menstrual bloodstains. It was found that steady-state fluorescence spectra underwent significant changes over first nine hours post deposition. The underlying mechanism of fluorescence changes was proposed to involve the kinetic transformation of three fluorophores: tryptophan, nicotinamide adenine dinucleotide and flavins.


===MeSH Terms===
|keywords=* Aging
-
* Chronic systemic inflammation
* Dysregulated CD4 T cells
* Immune-mediated repair
* Thymus
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101231
}}
{{medline-entry
|title=Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247896


===Keywords===
Aging; Analytical methods; Blood; Fluorescence spectroscopy; Forensics


==Winter honeybee ([i]Apis mellifera[/i]) populations show greater potential to induce immune response than summer ones after immune stimuli.==
|keywords=* HIV
===Abstract===
* exhaustion
In the temperate climates of middle Europe and North America, two distinct honeybee ([i]Apis mellifera[/i]) populations are found in colonies: short-living summer bees emerge in spring and survive until summer, whereas long-living winter bees emerge in late August and overwinter. Besides the difference in their life spans, each of these populations fulfills a different role in the colonies and individual bees have distinct physiological and immunological adaptations depending on their roles. For instance, winter worker bees have higher vitellogenin levels and larger reserves of nutrients in the fat body than summer bees. The differences between the immune systems of both populations are well described at the constitutive level; however, our knowledge of its inducibility is still very limited. In this study, we focus on the response of 10-day-old honeybee workers to immune challenges triggered [i]in vivo[/i] by injecting heat-killed bacteria, with particular focus on honeybees that emerge and live under hive conditions. Responses to bacterial injections differed between summer and winter bees. The latter induced more intense response, including higher expression of antimicrobial genes and antimicrobial activity, as well as a significant decrease in vitellogenin gene expression and its concentration in the hemolymph. The intense immune response observed in winter honeybees may contribute to our understanding of the relationships between colony fitness and infection with pathogens, as well as its association with successful overwintering.
* food insecurity
* immune activation
* senescence
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa1771
}}
{{medline-entry
|title=Rapamycin Eyedrops Increased [[CD4]] Foxp3  Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33255287


===MeSH Terms===
-


===Keywords===
|keywords=* aging
Antimicrobial peptides; Honeybee; Humoral immunity; Immune system; Longevity
* dry eye
* goblet cell
* inflammation
* lacrimal gland
* ocular surface
* rapamycin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727717
}}
{{medline-entry
|title=Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33228213


==Home-based exercise can be beneficial for counteracting sedentary behavior and physical inactivity during the COVID-19 pandemic in older adults.==
===Abstract===
The novel pandemic called coronavirus disease 2019 (COVID-19), as a global public health emergency, seems to be having a major impact on physical activity (PA) behaviors. Older adults are at high risk of death from the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Health authorities around the world have been implementing preventive health measures, including quarantine and self-isolation, to mitigate the COVID-19 outbreak. This period is characterized by cessation of outdoor exercising. During this period of lockdown, PA has been one of the rare reasons for going out in some countries. To avoid the harmful effects of periods of exercise cessation, PA could be prescribed to older adults, which is of great importance for breaking their sedentary lifestyle and improving their immunity. The present review discusses the potential impacts of COVID-19 pandemic on sedentary behavior and physical inactivity in older adults. The importance of performing PA to reduce the harmful effects of COVID-19 pandemic is discussed, and useful recommendations on home-based exercise for the older adults to maintain their level of independence, physical and mental health as well as their wellbeing are provided.


===MeSH Terms===
|keywords=* NAC
-
* T cells
* aging
* antioxidants
* immunosenescence
* vaccination
* vitamin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699597
}}
{{medline-entry
|title=Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198667


===Keywords===
Coronavirus; aging; exercise; health; physical activity; sedentary


==Abnormalities of Cortical Sources of Resting State Alpha Electroencephalographic Rhythms are Related to Education Attainment in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment.==
|keywords=* Aging
===Abstract===
* Cardiovascular events
In normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu-) educational attainment subgroups, were available in an Italian-Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu- subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu- subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray-white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.
* Chronic kidney disease
* Comorbidities
* HIV
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670698
}}
{{medline-entry
|title=Impact of age on [[CD4]] recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33183355


===MeSH Terms===
-


===Keywords===
|keywords=* Elders on antiretroviral drugs
aging; education attainment; exact low-resolution brain electromagnetic source tomography (eLORETA); mild cognitive impairment due to Alzheimer’s disease (ADMCI); resting state electroencephalographic (rsEEG) rhythms
* HIV and aging
* HIV treatment outcomes
* Sub-saharan Africa
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664082
}}
{{medline-entry
|title=hPMSCs protects against D-galactose-induced oxidative damage of [[CD4]]  T cells through activating Akt-mediated Nrf2 antioxidant signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148324


==Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.==
===Abstract===
Age-associated decline of the immune system is referred to as immunosenescence. The E3 ligase RING finger 10 (RNF10) has long been associated with the innate immune response, but a potential role in immunosenescence has not previously been reported. In the present study, we identified that RNF10 expression is lower in aged mouse macrophages than in young cells. After lipopolysaccharide (LPS) stimulation, RNF10 expression remained at a basal low level in aged mouse cells, but declined sharply in young mouse cells. Knockdown of RNF10 enhanced both the nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) signaling pathways and thus enhanced proinflammatory cytokines and type I interferons (IFN-I) in macrophages, promoting clearance of L. monocytigenes. These findings indicate that dysregulated expression of RNF10 is associated with age-associated immune dysfunction, and RNF10 may thus be a potential target for the treatment of age-related inflammatory diseases.


===MeSH Terms===
|keywords=* Aging
-
* CD4+ T cells
* Nrf2
* Oxidative stress
* Senescence-associated secretoryphenotype
* hPMSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641865
}}
{{medline-entry
|title=Substantial gap in primary care: older adults with HIV presenting late to care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129258


===Keywords===
E3 ubiquitin ligase; RNF10; immunosenescence; inflammation; macrophages


==Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b Ly6G  myeloid cells.==
|keywords=* Aging population
===Abstract===
* HIV
Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system reduces CD11b myeloid cellularity including CD11b Ly6G  and CD11b Ly6G  populations in mouse bone marrow. Surprisingly, Atg7 deletion causes abnormally accumulated histone H3.1 to be overwhelmingly trapped in the cytoplasm in the CD11b Ly6G , but not the CD11b Ly6G  compartment. RNA profiling revealed extensively chaotic expression of the genes required in nucleosome assembly. Functional assays further indicated upregulated aging markers in the CD11b Ly6G  population. Therefore, our study suggests that Atg7 is essential for maintaining proper nucleosome assembly and limiting aging in the bone marrow CD11b Ly6G  population.
* Older adults
* Risk
* Stigma
* Testing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603686
}}
{{medline-entry
|title=Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132893


===MeSH Terms===
-


===Keywords===
|keywords=* HIV—human immunodeficiency virus
Atg7; aging; histone H3.1; nucleosome assembly
* Parkinson’s disease
* aging
* fine motor activities
* motor control
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575770
}}
{{medline-entry
|title=Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33123168


==Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.==
===Abstract===
Ectopic expression of FOREVER YOUNG FLOWER (FYF) delays floral senescence and abscission in transgenic Arabidopsis. To analyze the FYF function in Phalaenopsis orchids, two FYF-like genes (PaFYF1/2) were identified. PaFYF1/2 were highly expressed in young Phalaenopsis flowers, and their expression decreased significantly afterward until flower senescence. This pattern was strongly correlated with the process of flower senescence and revealed that PaFYF1/2 function to suppress senescence/abscission during early flower development. Interestingly, in flowers, PaFYF1 was consistently expressed less in petals than in lips/sepals, whereas PaFYF2 was expressed relatively evenly in all flower organs. This difference suggests a regulatory modification of the functions of PaFYF1 and PaFYF2 during Phalaenopsis flower evolution. Delayed flower senescence and abscission, which were unaffected by ethylene treatment, were observed in 35S::PaFYF1/2 and 35S::PaFYF1/2+SRDX transgenic Arabidopsis plants due to downregulation of the ethylene signaling and abscission-associated genes EDF1-4, IDA and BOP1/2. These results suggest a possible repressor role for Phalaenopsis PaFYF1/2 in controlling floral senescence/abscission by suppressing ethylene signaling and abscission-associated genes. To further validate the function of PaFYF1/2, PaFYF1/2-VIGS (virus-induced gene silencing) Phalaenopsis were generated and analyzed. Promotion of senescence and abscission was observed in PaFYF1/2-VIGS Phalaenopsis flowers by the upregulation of PeEDF1/2, PeSAG39 and PeBOP1/2 expression, early occurrence of greening according to their increased chlorophyll content and reduction of water content in flower organs. Our results support that PaFYF1/2 function as transcriptional repressors to prohibit flower senescence and abscission in Phalaenopsis.


===MeSH Terms===
|keywords=* HIV
-
* T cell
* aging
* immune activation
* immune dysfunction
* inflammation
* monocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573236
}}
{{medline-entry
|title=HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33096437


===Keywords===


          FOREVER YOUNG FLOWER
|keywords=* Affective
        ;
* Aging
          Phalaenopsis orchids; Abscission; Ethylene responses; MADS-box gene; Senescence
* Aids
* Compassion
* Reflective
|full-text-url=https://sci-hub.do/10.1016/j.psychres.2020.113510
}}
{{medline-entry
|title=CD8  T cells are present at low levels in the white matter with physiological and pathological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049712


==Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.==
===Abstract===
Old skeletal muscle exhibits decreased anabolic sensitivity, eventually contributing to muscle wasting. Besides anabolism, also muscle inflammation and catabolism are critical players in regulating the old skeletal muscle's sensitivity. Omega-3 fatty acids (ω-3) are an interesting candidate to reverse anabolic insensitivity via anabolic actions. Yet, it remains unknown whether ω-3 also attenuates muscle inflammation and catabolism. The present study investigates the effect of ω-3 supplementation on muscle inflammation and metabolism (anabolism/catabolism) upon resistance exercise (RE). Twenty-three older adults (OA) (65-84yr;8♀) were randomized to receive ω-3 (~3g·d -1) or corn oil (PLAC) and engaged in a 12-wk RE program (3x·wk -1). Before and after intervention, muscle volume, strength and systemic inflammation were assessed, and muscle biopsies were analysed for markers of anabolism, catabolism and inflammation. Isometric knee-extensor strength increased in ω-3 (+12.2%), but not in PLAC (-1.4%; pinteraction=0.015), whereas leg press strength improved in both conditions (+27.1%; ptime<0.001). RE, but not ω-3, decreased inflammatory (p65NF-κB) and catabolic (FOXO1, LC3b) markers, and improved muscle quality. Yet, muscle volume remained unaffected by RE and ω-3. Accordingly, muscle anabolism (mTORC1) and plasma CRP remained unchanged by RE and ω-3, whereas serum IL-6 tended to decrease in ω-3 (pinteraction=0.07). These results show that, despite no changes in muscle volume, RE-induced gains in isometric strength can be further enhanced by ω-3. However, ω-3 did not improve RE-induced beneficial catabolic or inflammatory adaptations. Irrespective of muscle volume, gains in strength (primary criterion for sarcopenia) might be explained by changes in muscle quality due to muscle inflammatory or catabolic signaling.


===MeSH Terms===
|keywords=* aging
-
* neuroscience
* pathology
|full-text-url=https://sci-hub.do/10.18632/aging.104043
}}
{{medline-entry
|title=Immunotherapy in older patients with cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041248


===Keywords===
Muscle wasting; aging; anabolic resistance; inflammation; resistance training; sarcopenia


==Anti-aging technoscience & the biologization of cumulative inequality: Affinities in the biopolitics of successful aging.==
|keywords=* Ageing
===Abstract===
* Cancer
This paper charts the emergence of under-remarked affinities between contemporary anti-aging technoscience and some social scientific work on biological aging. Both have recently sought to develop increasingly sophisticated operationalizations of age, aging and agedness as biological phenomena, in response to traditional notions of normal and chronological aging. Rather than being an interesting coincidence, these affinities indicate the influence of a biopolitics of successful aging on government, industry and social science. This biopolitics construes aging as a personal project that is mastered through specific forms of entrepreneurial individual action, especially consumption practices. Social scientists must remain alert to this biopolitics and its influence on their own work, because the individualization of cumulative inequalities provides intellectual and moral justifications for anti-aging interventions that exploit those inequalities.
* Elderly
* Immunosenescence
* Immunotherapy
* Old people
* Oncogeriatry
|full-text-url=https://sci-hub.do/10.1016/j.bj.2020.07.009
}}
{{medline-entry
|title=Multiple genetic programs contribute to [[CD4]] T cell memory differentiation and longevity by maintaining T cell quiescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32987276


===MeSH Terms===
-


===Keywords===
|keywords=* CD4 T cell
Active aging; Biological age; Biomarker; Cumulative advantage; Functional age
* Cell longevity
* Gene
* Genetic programs
* Memory T cell
* Memory cell markers
|full-text-url=https://sci-hub.do/10.1016/j.cellimm.2020.104210
}}
{{medline-entry
|title=Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013907


==Associations between Alzheimer's disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants.==
===Abstract===
Hippocampal volume is an important biomarker of Alzheimer's disease (AD), and genetic risk of AD is associated with hippocampal atrophy. However, the hippocampus is not a uniform structure and has a number of subfields, the associations of which with age, sex, and polygenic risk score for AD (PRS ) have been inadequately investigated. We examined these associations in 17,161 cognitively normal UK Biobank participants (44-80 years). Age was negatively associated with all the hippocampal subfield volumes and females had smaller volumes than men. Higher PRS  was associated with lower volumes in the bilateral whole hippocampus, hippocampal-amygdala-transition-area, and hippocampal tail; right subiculum; left cornu ammonis 1, cornu ammonis 4, molecular layer, and granule cell layer of dentate gyrus. Older individuals (median age 63 years, n = 8984) showed greater subfield vulnerability to high PRS  compared to the younger group (n = 8177), but the effect did not differ by sex. The pattern of subfield involvement in relation to the PRS  in community dwelling healthy individuals sheds additional light on the pathogenesis of AD.


===MeSH Terms===
|keywords=* T cell
-
* aging
* autologous stem cell transplant
* metabolism
* myeloma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758
}}
{{medline-entry
|title=Immunosenescence: the role of age in multiple sclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962809


===Keywords===
Aging; Alzheimer’s disease; Hippocampal subfields; Polygenic risk score


==Maybe Age Isn't Just a Number: Elderly-onset IBD Is a Demographic Deserving of Specific Considerations.==
|keywords=* Ageing
===Abstract===
* Envejecimiento
---
* Esclerosis múltiple
* Esclerosis múltiple de comienzo tardío
* Immunosenescence
* Inmunosenescencia
* Late-onset multiple sclerosis
* Multiple sclerosis
|full-text-url=https://sci-hub.do/10.1016/j.nrl.2020.05.016
}}
{{medline-entry
|title=Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32924972


===MeSH Terms===
-


===Keywords===
|keywords=* aged
Crohn’s disease; aging; biologics; colitis; infections
* senescence
* thymus
* transplantation
* umbilical cord mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521525
}}
{{medline-entry
|title=Impaired Cytotoxic CD8  T Cell Response in Elderly COVID-19 Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32948688


==Effect of air-abrasion at pre- and/or post-sintered stage and hydrothermal aging on surface roughness, phase transformation, and flexural strength of multilayered monolithic zirconia.==
|mesh-terms=* Aged, 80 and over
===Abstract===
* Antigens, CD
This study aimed to evaluate the effect of air-abrasion/sintering order and autoclave aging on the surface roughness (Ra), phase transformation, and biaxial flexural strength (BFS) of monolithic zirconia. A total of 104 monolithic zirconia specimens (Katana ML) were divided into eight groups according to airborne-particle abrasion protocols and hydrothermal aging: control (non-aged: C-, aged: C+), air-abrasion before sintering (BS-, BS+), air-abrasion after sintering (AS-, AS+), and air-abrasion before and after sintering (BAS-, BAS+). A steam autoclave was used for accelerated aging, and Ra values were measured with a surface profilometer. All specimens were analyzed by X-ray diffraction to determine any phase transformation on the zirconia surface. BFS was measured by using the piston-on-three-balls method. Scanning electron microscopy and atomic force microscopy were performed on one specimen per group. BS and BAS groups showed higher Ra values compared with groups C and AS. The aging process significantly increased the monoclinic phase content of all specimens. Lower monoclinic levels were found in AS+ and BAS+ compared with other aged groups. The AS groups exhibited higher flexural strength values relative to control groups, whereas BS groups exhibited significantly lower flexural strength values (p < .05). There was no reduction in flexural strength by using the BAS protocol. Air-abrasion of zirconia at the pre-sintered stage only is not recommended in clinical use because of the remarkable decrease in flexural strength.
* Betacoronavirus
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* COVID-19
* Coronavirus Infections
* Cytotoxins
* Female
* Humans
* Immunity, Cellular
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* SARS-CoV-2
* T-Lymphocyte Subsets
* T-Lymphocytes, Cytotoxic
|keywords=* CD4+


===MeSH Terms===
* CD8+
-


===Keywords===
* COVID-19
airborne-particle abrasion; flexural strength; hydrothermal aging; monolithic zirconia; phase transformation
* PD-1
* SARS-CoV-2
* aging
* cytotoxic T cells
* granzyme
* perforin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502863
}}
{{medline-entry
|title=What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32875286


==Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan.==
===Abstract===
Caloric restriction (CR), the reduction of caloric intake without inducing malnutrition, is the most reproducible method of extending health and lifespan across numerous organisms, including humans. However, with nearly one-third of the world's population overweight, it is obvious that caloric restriction approaches are difficult for individuals to achieve. Therefore, identifying compounds that mimic CR is desirable to promote longer, healthier lifespans without the rigors of restricting diet. Many compounds, such as rapamycin (and its derivatives), metformin, or other naturally occurring products in our diets (nutraceuticals), induce CR-like states in laboratory models. An alternative to CR is the removal of specific elements (such as individual amino acids) from the diet. Despite our increasing knowledge of the multitude of CR approaches and CR mimetics, the extent to which these strategies overlap mechanistically remains unclear. Here we provide an update of CR and CR mimetic research, summarizing mechanisms by which these strategies influence genome function required to treat age-related pathologies and identify the molecular fountain of youth.


===MeSH Terms===
|keywords=* Antibodies
-
* Antibody-dependent enhancement
* CD8 T-cells
* COVID-19
* Durable immunity
* Protective immunity
* SARS
* SARS-CoV-2
* T cell lifespan
* T-cell epitopes
* T-cells
* Vaccines
* Yellow Fever Vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452821
}}
{{medline-entry
|title=Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850472


===Keywords===
amino acid restriction; caloric restriction; caloric restriction mimetics; general control nonderepressible 2 (GCN2); healthspan; lifespan; mammalian target of rapamycin (mTOR)


==Heart and neural crest derivative 2-induced preservation of sympathetic neurons attenuates sarcopenia with aging.==
|keywords=* HIV
===Abstract===
* Sirtuin 1
Sarcopenia, or age-dependent decline in muscle force and power, impairs mobility, increasing the risk of falls, institutionalization, co-morbidity, and premature death. The discovery of adrenoceptors, which mediate the effects of the sympathetic nervous system (SNS) neurotransmitter norepinephrine on specific tissues, sparked the development of sympathomimetics that have profound influence on skeletal muscle mass. However, chronic administration has serious side effects that preclude their use for muscle-wasting conditions. Interventions that can adjust neurotransmitter release to changing physiological demands depend on understanding how the SNS affects neuromuscular transmission, muscle motor innervation, and muscle mass. We examined age-dependent expression of the heart and neural crest derivative 2 (Hand2), a critical transcription factor for SN maintenance, and we tested the possibility that inducing its expression exclusively in sympathetic neurons (SN) will prevent (i) motor denervation, (ii) impaired neuromuscular junction (NMJ) transmission, and (iii) loss of muscle mass and function in old mice. To test this hypothesis, we delivered a viral vector carrying Hand2 expression or an empty vector exclusively in SNs by vein injection in 16-month-old C57BL/6 mice that were sacrificed 6 months later. Techniques include RNA-sequencing, real-time PCR, genomic DNA methylation, viral vector construct, tissue immunohistochemistry, immunoblot, confocal microscopy, electrophysiology, and in vivo mouse physical performance. Hand2 expression declines throughout life, but inducing its expression increased (i) the number and size of SNs, (ii) muscle sympathetic innervation, (iii) muscle weight and force and whole-body strength, (iv) myofiber size but not muscle fibre-type composition, (v) NMJ transmission and nerve-evoked muscle force, and (vi) motor innervation in old mice. Additionally, the SN controls a set of genes to reduce inflammation and to promote transcription factor activity, cell signalling, and synapse in the skeletal muscle. Hand2 DNA methylation may contribute, at least partially, to gene silencing. Selective expression of Hand2 in the mouse SNs from middle age through old age increases muscle mass and force by (i) regulating skeletal muscle sympathetic and motor innervation; (ii) improving acetylcholine receptor stability and NMJ transmission; (iii) preventing inflammation and myofibrillar protein degradation; (iv) increasing autophagy; and (v) probably enhancing protein synthesis.
* hematopoietic progenitor cells
* period circadian clock 2
* senescence
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396677
}}
{{medline-entry
|title=COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32802142


===MeSH Terms===
-


===Keywords===
|keywords=* ACE2
Aging; Denervation; Neuromuscular junction; Sarcopenia; Skeletal muscle; Sympathetic nervous system
* C-reactive protein
* COVID-19
* Immunity
* Immunosenescence
* Interleukin-6
* Lymphocytes
* Renin-angiotensin system
* Severe acute respiratory syndrome coronavirus 2
* Spain
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426672
}}
{{medline-entry
|title=Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735896


==Contributions of Hippocampal Volume to Cognition in Healthy Older Adults.==
===Abstract===
: The association between hippocampal volume and memory is continuing to be characterized in healthy older adults. Prior research suggests smaller hippocampal volume in healthy older adults is associated with poorer episodic memory and processing speed, as well as working memory, verbal learning, and executive functioning as measured by the NIH Toolbox Fluid (Fluid Cognition Composite, FCC) and Crystalized Cognition Composites (CCC). This study aimed to replicate these findings and to evaluate the association between: (1) hippocampal asymmetry index and cognition; and (2) independent contributions of the left and right hippocampal volume and cognition in a large sample of healthy older adults.  : One-hundred and eighty-three healthy older adults (M age = 71.72, SD = 5.3) received a T1-weighted sequence on a 3T scanner. Hippocampal subfields were extracted using FreeSurfer 6.0 and combined to provide left, right, and total hippocampal volumes. FCC subtests include Dimensional Change Card Sort, Flanker Inhibitory Control and Attention, List Sorting, Picture Sequence Memory, and Pattern Comparison. CCC subtests include Picture Vocabulary and Oral Reading Recognition. Multiple linear regressions were performed predicting cognition composites from the total, left and right, and asymmetry of hippocampal volume, controlling for sex, education, scanner, and total intracranial volume. Multiple comparisons in primary analyses were corrected using a false discovery rate (FDR) of [i]p[/i] < 0.05.  : FCC scores were positively associated with total ([i]β[/i] = 0.226, FDR [i]q[/i] = 0.044) and left ([i]β[/i] = 0.257, FDR [i]q[/i] = 0.024) hippocampal volume. Within FCC, Picture Sequence Memory scores positively associated with total ([i]β[/i] = 0.284, [i]p[/i] = 0.001) and left ([i]β[/i] = 0.98, [i]p[/i] = 0.001) hippocampal volume. List Sorting scores were also positively associated with left hippocampal volume ([i]β[/i] = 0.189, [i]p[/i] = 0.029).  : These results confirm previous research suggesting that bilateral hippocampal volume is associated with FCC, namely episodic memory. The present study also suggests the left hippocampal volume may be more broadly associated with both episodic and working memory. Studies should continue to investigate lateralized hippocampal contributions to aging processes to better identify predictors of cognitive decline.


===MeSH Terms===
|keywords=* immunosenescence
-
* lymphocyte compartments
* physical performance
* sarcopenia
* very old adults
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111321
}}
{{medline-entry
|title=Homeostasis and the functional roles of [[CD4]]  Treg cells in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717201


===Keywords===
NIH toolbox; aging; brain volume; cognition; hippocampus; magnetic resonance imaging


==Addressing stereotypes of aging and interest in careers working with older adults through education.==
|keywords=* Aging
===Abstract===
* Autoimmunity
Negative stereotypes about older adults are increasing and contributing to a shortage of professionals in gerontology. Building on the PEACE model (Positive Education about Aging and Contact Experiences), two experiments used education to address stereotypes associated with older adults. Participants were randomly assigned to read brief articles that: challenged stereotypes about older adults (condition 1), challenged stereotypes about careers working with older adults (condition 2), challenged both stereotypes (condition 3), or described careers in general (control; condition 4). In Study 1, 399 undergraduates in all 3 experimental conditions (vs. control participants) reported lower levels of ageism, more positive age perceptions, and more aging knowledge in an immediate and delayed (1-2 weeks) post-test. In Study 2, 446 national community participants (ages 18- 25) in all experimental conditions (vs. control participants) reported greater positive age perceptions, aging knowledge, and interest in psychology and social work careers with older adults in an immediate post-test. These findings highlight the promise of using brief online methods to challenge stereotypes, provide more positive and accurate views of aging and older adults, and increase interest in careers working with older adults. Implications are discussed.
* Cancer
* FOXP3
* Immune senescence
* Immune suppression
* Inflammaging
* Regulatory T cells
* T helper 17
* Treg
|full-text-url=https://sci-hub.do/10.1016/j.imlet.2020.07.004
}}
{{medline-entry
|title=A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707687


===MeSH Terms===
-


===Keywords===
|keywords=* A2 beta-casein
Experiment; geriatrics; geropsychology; intervention; prejudice reduction
* SCFAs
* elderly
* gut inflammation
* gut microbiota
* gut morphology
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400800
}}
{{medline-entry
|title=Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660510


==Mutation in histone deacetylase HDA-3 leads to shortened locomotor healthspan in [i]Caenorhabditis elegans[/i].==
===Abstract===
Some genes are essential for survival, while other genes play modulatory roles on health and survival. Genes that play modulatory roles may promote an organism's survival and health by fine-tuning physiological processes. An unbiased search for genes that alter an organism's ability to maintain aspects of health may uncover modulators of lifespan and healthspan. From an unbiased screen for [i]Caenorhabditis elegans[/i] mutants that show a progressive decline in motility, we aimed to identify genes that play a modulatory role in maintenance of locomotor healthspan. Here we report the involvement of [i]hda-3,[/i] encoding a class I histone deacetylase, as a genetic factor that contributes in the maintenance of general health and locomotion in [i]C. elegans[/i]. We identified a missense mutation in HDA-3 as the causative mutation in one of the isolated strains that show a progressive decline in maximum velocity and travel distance. From transcriptome analysis, we found a cluster of genes on Chromosome II carrying BATH domains that were downregulated by [i]hda-3[/i]. Furthermore, downregulation of individual [i]bath[/i] genes leads to significant decline in motility. Our study identifies genetic factors that modulate the maintenance of locomotor healthspan and may reveal potential targets for delaying age-related locomotor decline.


===MeSH Terms===
|keywords=* Hemodialysis
-
* Inflammation
* Mortality
* T cell aging
* naïve T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359274
}}
{{medline-entry
|title=In-depth immune cellular profiling reveals sex-specific associations with frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582361


===Keywords===
BATH domain; age-related locomotor impairment; aging; hda-3; longevity


==CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.==
|keywords=* Frailty
===Abstract===
* Healthy aging
An adequate development of the placenta includes trophoblast differentiation with the processes of trophoblast migration, invasion, cellular senescence and apoptosis which are all crucial to establishing a successful pregnancy. Altered placental development and function lead to placental diseases such as preeclampsia (PE) which is mainly characterized by insufficient trophoblast invasion and abnormally invasive placenta (AIP) disorders ([i]Placenta accreta[/i], [i]increta[/i], or [i]percreta)[/i] which are characterized by excessive trophoblast invasion. Both of them will cause maternal and fetal morbidity/mortality. However, the etiology of these diseases is still unclear. Our previous study has shown that the matricellular protein [i]nephroblastoma overexpressed[/i] (NOV, CCN3) induces G0/G1 cell cycle arrest, drives trophoblast cells into senescence and activates FAK and Akt kinases resulting in reduced cell proliferation and enhanced migration capability of the human trophoblast cell line SGHPL-5. The present study focuses on whether CCN3 can alter cell cycle-regulated pathways associated with trophoblast senescence and invasion activity in pathological versus gestational age-matched control placentas. Cell cycle regulator proteins were investigated by immunoblotting and qPCR. For localization of CCN3, p16, p21, and Cyclin D1 proteins, co-immunohistochemistry was performed. In early-onset PE placentas, CCN3 was expressed at a significantly lower level compared to gestational age-matched controls. The decrease of CCN3 level is associated with an increase in p53, Cyclin E1 and pRb protein expression, whereas the level of cleaved Notch-1, p21, Cyclin D1, pFAK, pAKT, and pmTOR protein decreased. In term AIP placentas, the expression of CCN3 was significantly increased compared to matched term controls. This increase was correlated to an increase in p53, p16, p21, Cyclin D1, cleaved Notch-1, pFAK, pAkt, and pmTOR whereas pRb was significantly decreased. However, in late PE and early AIP placentas, no significant differences in CCN3, p16, p21, Cyclin D1, p53, and cleaved Notch-1 expression were found when matched to appropriate controls. CCN3 expression levels are correlated to markers of cell cycle arrest oppositely in PE and AIP by activating the FAK/AKT pathway in AIP or down-regulating in PE. This may be one mechanism to explain the different pathological features of placental diseases, PE and AIP.
* Immune cellular profiling
* Immune homeostasis
* Immunosenescence
* Sex-specific immune profile
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310472
}}
{{medline-entry
|title=CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559178


===MeSH Terms===
-


===Keywords===
|keywords=* CD70
CCN3; abnormally invasive placenta; invasion; preeclampsia; senescence; trophoblast
* T cell aging
* co-inhibitory molecules
* immunosenescence
* overwhelming inflammatory responses
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343466
}}
{{medline-entry
|title=Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539152


==Understanding the Clinical Features of Coronavirus Disease 2019 From the Perspective of Aging: A Systematic Review and Meta-Analysis.==
|mesh-terms=* Adult
===Abstract===
* Chronic Disease
An outbreak of novel coronavirus (2019-nCov) infection is now widespread in multiple countries. Compared with adult patients, elderly patients have not received enough attention. The aim of the meta-analysis was to assess the clinical characteristics of elder patients with COVID-19. A deep literature search was performed in the databases through August 21, 2020. Risk ratio (OR) and 95% confidence intervals (CIs) were pooled using analysis models. Three studies including 2046 infected patients were precisely evaluated, and the results show that the elderly group has a higher risk of hypertension, diabetes, and cardiovascular disease than the younger patients. Their total white blood cells are higher than that of the younger patients, and their lymphocytes are relatively reduced compared with the younger patients. We comprehensively assessed the clinical characteristics of patients of different ages with COVID-19 and found that elder patients had a high risk of chronic cardiovascular and metabolism comorbidities. The characteristic clinical manifestations and laboratory examinations of elderly patients support their excessive inflammation and weak immune defenses against 2019-nCoV. All these findings provide important information for understanding the general clinical characterization of the aging immune defense against the virus and enhancing the public awareness of the prevention and treatment of elder patients in the COVID-19 pandemic.
* Cohort Studies
* Comorbidity
* Female
* HIV Infections
* Humans
* Insurance, Health
* Life Expectancy
* Male
* Middle Aged


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296391
-
}}
{{medline-entry
|title=Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545199


===Keywords===
2019 coronavirus disease; 2019 novel coronavirus; aging patients; clinical characteristics; immune senescence; meta-analysis


==A systematic review of center of pressure measures to quantify gait changes in older adults.==
|keywords=* aging
===Abstract===
* dry eye
Measures of gait center of pressure (COP) can be recorded using simple available technologies in clinical settings and thus can be used to characterize gait quality in older adults and its relationship to falls. The aim of this systematic review was to investigate the association between measures of gait COP and aging and falls. A comprehensive search of electronic databases including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CINAHL (EBSCO), Ageline (EBSCO) and Scopus was performed. The initial search yielded 2809 papers. After removing duplicates and applying study inclusion/exclusion criteria, 34 papers were included in the review. Gait COP has been examined during three tasks: normal walking, gait initiation, and obstacle negotiation. The majority of studies examined mean COP position and velocity as outcome measures. Overall, gait in older adults was characterized by more medial COP trajectory in normal walking and lower average anterior-posterior and medio-lateral COP displacements and velocity in both gait initiation and obstacle crossing. Moreover, findings suggest that Tai chi training can enhance older adults' balance control during gait initiation as demonstrated by greater COP backward, medial and forward shift in all three phases of gait initiation. These findings should be interpreted cautiously due to inadequacy of evidence as well as methodological limitations of the studies such as small sample size, limited numbers of 'fallers', lack of a control group, and lack of interpretation of COP outcomes with respect to fall risk. COP measures can be adopted to assess fall-related gait changes in older adults but more complex measures of COP that reveal the dynamic nature of COP behavior in step-to-step variations are needed to adequately characterize gait changes in older adults.
* inflammation
* lacrimal glands
* meibomian glands
* oxidative stress
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313015
}}
{{medline-entry
|title=Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32506584


===MeSH Terms===
-


===Keywords===
|keywords=* senescence
Biomechanics; Geriatrics; Stability; Walking
* thymic epithelial cells
* thymocytes
|full-text-url=https://sci-hub.do/10.1002/dvdy.212
}}
{{medline-entry
|title=CD8  T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452087


==Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults.==
===Abstract===
Engaging patients-defined broadly as individuals with lived experience of a given condition, family members, caregivers, and the organisations that represent them-as partners in research is a priority for policymakers, funders, and the public. Nonetheless, formal efforts to engage patients are absent from most studies, and models to support meaningful patient engagement in clinical anaesthesia research have not been previously described. Here, we review our experience in developing and implementing a multifaceted patient engagement strategy within the Regional Versus General Anesthesia for Promoting Independence After Hip Fracture (REGAIN) surgery trial, an ongoing randomised trial comparing spinal vs general anaesthesia for hip fracture surgery in 1600 older adults across 45 hospitals in the USA and Canada. This strategy engaged patients and their representatives at both the level of overall trial oversight and at the level of individual recruiting sites. Activities spanned a continuum ranging from events designed to elicit patients' input on key decisions to longitudinal collaborations that empowered patients to actively participate in decision-making related to trial design and management. Engagement activities were highly acceptable to participants and led to concrete changes in the design and conduct of the REGAIN trial. The REGAIN experience offers a model for future efforts to engage patients as partners in clinical anaesthesia research, and highlights potential opportunities for investigators to increase the relevance of anaesthesia studies by incorporating patient voices and perspectives into the research process.


===MeSH Terms===
|keywords=*
-
DKC1


===Keywords===
*
anaesthesia; geriatrics; hip fracture; patient advocacy; patient engagement; research methods; shared decision-making
PARN


==Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.==
* Dyskeratosis Congenita
===Abstract===
* primary immunodeficiency
Mesenchymal stromal cell (MSC) transplantation is a form of the stem-cell therapy that has shown beneficial effects for many diseases. The use of stem-cell therapy, including MSC transplantation, however, has limitations such as the tumorigenic potential of stem cells and the lack of efficacy of aged autologous cells. An ideal therapeutic approach would keep the beneficial effects of MSC transplantation while circumventing the limitations associated with the use of intact stem cells. This study provides proof-of-concept evidence that MSC-derived extracellular vesicles represent a promising platform to develop an acellular therapeutic approach that would just do that. Extracellular vesicles are membranous vesicles secreted by MSCs and contain bioactive molecules to mediate communication between different cells. Extracellular vesicles can be taken up by recipient cells, and once inside the recipient cells, the bioactive molecules are released to exert the beneficial effects on the recipient cells. This study, for the first time to our knowledge, shows that extracellular vesicles secreted by MSCs recapitulate the beneficial effects of MSCs on vascular repair and promote blood vessel regeneration after ischemic events. Furthermore, MSCs from aged donors can be engineered to produce extracellular vesicles with improved regenerative potential, comparable to MSCs from young donors, thus eliminating the need for allogenic young donors for elderly patients.
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521304
}}
{{medline-entry
|title=Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32451728


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
BM, bone marrow; CVD, cardiovascular disease; EC, endothelial cell; EPC, endothelial progenitor cell; EV, extracellular vesicle; FBS, fetal bovine serum; MEM, minimum essential medium; MI, myocardial infarction; MSC, mesenchymal stromal cell; NTA, nanotracking analysis; PBS, phosphate-buffered saline; TEV, tailored extracellular vesicle; VEGF, vascular endothelial growth factor; acellular; angiogenesis; extracellular vesicles; lin− BMC, lineage negative bone marrow cell; miR, microRNA; qPCR, quantitative transcription polymerase chain reaction; regeneration; senescence
* Astrocytes
* Environmental enrichment
* Microglia
* Physical exercise
* T cells
|full-text-url=https://sci-hub.do/10.1007/s10571-020-00862-x
}}
{{medline-entry
|title=Viral and host factors related to the clinical outcome of COVID-19.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434211


==Inflammaging in Endemic Areas for Infectious Diseases.==
|mesh-terms=* Adolescent
===Abstract===
* Adult
Immunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory [i]versus[/i] remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts.
* Aged
* Aged, 80 and over
* Aging
* Animals
* Asymptomatic Infections
* Betacoronavirus
* COVID-19
* China
* Cohort Studies
* Coronavirus Infections
* Critical Illness
* Disease Progression
* Evolution, Molecular
* Female
* Genetic Variation
* Genome, Viral
* Hospitalization
* Host-Pathogen Interactions
* Humans
* Inflammation Mediators
* Interleukin-6
* Interleukin-8
* Lymphocyte Count
* Lymphopenia
* Male
* Middle Aged
* Pandemics
* Phylogeny
* Pneumonia, Viral
* Respiratory Distress Syndrome
* SARS-CoV-2
* T-Lymphocytes
* Time Factors
* Treatment Outcome
* Virulence
* Virus Shedding
* Young Adult
* Zoonoses


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2355-0
-
}}
{{medline-entry
|title=Use of comedications and potential drug-drug interactions in people living with HIV in China.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32354599


===Keywords===
aging; chronic infection; dietary components; genetics; inflammaging; inflammation; microbiota


==[Key Molecular Mechanisms of Aging, Biomarkers, and Potential Interventions].==
|keywords=* Aging
===Abstract===
* China
The mechanisms of aging are described at the molecular, cell, tissue, and systemic levels. Primary age-dependent molecular lesions activate the cell stress response to compensate for the resulting defects, but the mechanisms that recover and maintain homeostasis are gradually deteriorated. When the amount of errors reaches a critical threshold in regulatory networks, a phase transition from health to disease occurs at the systemic level. The review considers the approaches to quantitative assessment of the aging process (biomarkers of aging) and promising interventions to slow down the aging process and to reduce the risk of age-dependent diseases.
* Co-medication
* Drug-drug interaction
* HIV
|full-text-url=https://sci-hub.do/10.1016/j.jiac.2020.04.003
}}
{{medline-entry
|title=[[CD4]]  T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32356608


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* CD4-Positive T-Lymphocytes
* Cell Differentiation
* Cell Line, Tumor
* Cell Movement
* Humans
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Models, Animal
* NF-kappa B
* Neoplasm Invasiveness
* PC-3 Cells
* Prostatic Neoplasms
* Th17 Cells
|keywords=* CD4+ T cell-secreted factors
* PCa cells
* Th17 cytokines
* aging
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310589
}}
{{medline-entry
|title=The Rules of Human T Cell Fate [i]in vivo[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32322253


===Keywords===
age-dependent diseases; aging; biomarkers of aging; geroprotectors


==Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.==
|keywords=* decision
===Abstract===
* fate
Animals tend to increase in body weight and body condition score (BCS) with aging. Serum diagnostic markers related to energy metabolism may show changes even in healthy cats with aging. Seventy domestic cats were recruited for this study. Based upon the modified AAFP-AAHA Feline Life Stage Guidelines, animals were divided into six groups: Junior (7 months-2 years), Prime (3 -6 years), Mature (7-10 years), Senior (11-14 years), Geriatric-obese (15 years ≤) and Geriatric-thin (15 years ≤). Their body condition scores (BCS) ranged from 3/9 to 9/9. Changes in metabolites, inflammatory markers, hormone concentrations and enzyme activities related to energy metabolism were investigated in serum of 70 domestic cats of various ages. Serum glucose (GLU) concentrations in the Mature, Senior, and Geriatric-obese groups were significantly higher than those in the Junior group. Serum amyloid A (SAA) concentrations in the Geriatric-thin group were significantly increased compared with the Junior group. SAA concentrations in the Geriatric-obese group tended to increase although there were no statistically significant differences. In the Mature, Senior, Geriatric-obese and Geriatric-thin groups, malate dehydrogenase/lactate dehydrogenase (M/L) ratio, an energy metabolic indicator, tended to decrease compared with the Junior group. In the Senior group, triglyceride (TG) concentrations were significantly increased compared with the Junior group. In the Geriatric-obese and Geriatric-thin groups, blood urea nitrogen (BUN) concentrations were significantly increased compared with the Junior group. In the Geriatric-obese group, albumin (ALB) concentrations were decreased compared with the Junior group. Aged domestic cats tend to increase in body weight and BCS. In addition, serum GLU, TG, SAA, and BUN concentrations increased and serum ALB concentrations and M/L ratio decreased. These diagnostic markers may be useful to detect small changes related to energy metabolism with aging that may cause obesity with light inflammation in healthy cats.
* half-life
* labeling
* lifespan
* lymphocyte
* mathematical model
* proliferation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156550
}}
{{medline-entry
|title=[[CD4]]/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314818


===MeSH Terms===
-


===Keywords===
|keywords=* CD4/CD8 ratio
M/L ratio; SAA; aging; domestic cats; obesity
* HIV
* aging
* comorbidities
|full-text-url=https://sci-hub.do/10.1002/jmv.25911
}}
{{medline-entry
|title=The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279324


==Prevalence and prognostic value of the coexistence of anaemia and frailty in older patients with heart failure.==
|mesh-terms=* Adult
===Abstract===
* Aging
There have been no investigations of the prevalence and clinical implications of coexistence of anaemia and frailty in older patients hospitalized with heart failure (HF) despite their association with adverse health outcomes. The present study was performed to determine the prevalence and prognostic value of the coexistence of anaemia and frailty in hospitalized older patients with HF. We performed post hoc analysis of consecutive hospitalized HF patients ≥65 years old enrolled in the FRAGILE-HF, which was the prospective, multicentre, observational study. Anaemia was defined as haemoglobin < 13 g/dL in men and <12 g/dL in women, and frailty was evaluated according to the Fried phenotype model. The study endpoint was all-cause mortality. Of the total of 1332 patients, 1217 (median age, 81 years; 57.4% male) were included in the present study. The rates of anaemia and frailty in the study population were 65.7% and 57.0%, respectively. The patients were classified into the non-anaemia/non-frail group (16.6%), anaemia/non-frail group (26.4%), non-anaemia/frail group (17.7%), and anaemia/frail group (39.3%). A total of 144 patients died during 1 year of follow-up. In multivariate analyses, only the anaemia/frail group showed a significant association with elevated mortality rate (adjusted hazard ratio, 1.94; 95% confidence interval, 1.02-3.70; P = 0.043), compared with the non-anaemia/non-frail group after adjusting for other covariates. Coexistence of anaemia and frailty are prevalent in hospitalized older patients with HF, and it has a negative impact on mortality.
* Animals
* Female
* Humans
* Live Birth
* Mice
* Mice, Transgenic
* Placenta
* Pregnancy
* T-Lymphocyte Subsets
|keywords=* birth weight
* neonate
* offspring
* pregnancy
* preterm labor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290081
}}
{{medline-entry
|title=Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32248450


===MeSH Terms===
-


===Keywords===
|keywords=* age-related involution
Anaemia; Frailty; Geriatrics; Heart failure in elderly; Prognosis
* aging
* immune system
* immunomorphology
* mesenteric lymph nodes
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04782-0
}}
{{medline-entry
|title=Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090235


==[Age-related features of the relationship between the content of vascular endothelial growth factor and indicators of lipid metabolism and extracellular matrix metabolism in men in the European part of the Russian Arctic.]==
|mesh-terms=* Adult
===Abstract===
* Cognition
The content of vascular endothelial growth factor-A (VEGF-A) in blood plasma and its relationship with lipid and extracellular matrix metabolism in working-aged men (19-69 years), living and working in the European part of the Arctic zone of the Russian Federation (Russian Arctic), were studied. No age dependence of the plasma VEGF-A content was found. The correlation analysis, performed in different age groups, revealed significant associations of VEGF-A level with lipid parameters (CS, LDL-C, Apo B, atherogenicity coefficient, Apo B /Apo A1 ratio) and extracellular matrix metabolism (blood TIMP-4, MMP-2, MMP-3, MMP-9, hyaluronan, total and peptide-bound hydroxyproline, glycosaminoglycans). The established correlations indicate the formation of relationships between angiogenesis, atherogenesis and fibrosis at a specific period of life of northerners in the Russian Arctic.
* Cross-Sectional Studies
* HIV Infections
* Health Literacy
* Humans
* Neuropsychological Tests
* Self Report
|keywords=* Adherence
* Aging
* Cognitive impairment
* HIV/AIDS
* Health illiteracy
* Observational study
|full-text-url=https://sci-hub.do/10.1093/arclin/acaa005
}}
{{medline-entry
|title=Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064174


===MeSH Terms===
-


===Keywords===
|keywords=* Stat3
European part of the Arctic zone of the Russian Federation; aging; angiogenesis; hypoxia; vascular endothelial growth factor (VEGF)
* immune checkpoint blockade
* immunotherapy
* oncogene addiction
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996562
}}
{{medline-entry
|title=Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32082401


==Relationship between the disrupted topological efficiency of the structural brain connectome and glucose hypometabolism in normal aging.==
===Abstract===
Normal aging is accompanied by structural degeneration and glucose hypometabolism in the human brain. However, the relationship between structural network disconnections and hypometabolism in normal aging remains largely unknown. In the present study, by combining MRI and PET techniques, we investigated the metabolic mechanism of the structural brain connectome and its relationship with normal aging in a cross-sectional, community-based cohort of 42 cognitively normal elderly individuals aged 57-84 years. The structural connectome was constructed based on diffusion MRI tractography, and the network efficiency metrics were quantified using graph theory analyses. FDG-PET scanning was performed to evaluate the glucose metabolic level in the cortical regions of the individuals. The results of this study demonstrated that both network efficiency and cortical metabolism decrease with age (both p < 0.05). In the subregions of the bilateral thalamus, significant correlations between nodal efficiency and cortical metabolism could be observed across subjects. Individual-level analyses indicated that brain regions with higher nodal efficiency tend to exhibit higher metabolic levels, implying a tight coupling between nodal efficiency and glucose metabolism (r = 0.56, p = 1.15 × 10 ). Moreover, efficiency-metabolism coupling coefficient significantly increased with age (r = 0.44, p = 0.0046). Finally, the main findings were also reproducible in the ADNI dataset. Together, our results demonstrate a close coupling between structural brain connectivity and cortical metabolism in normal elderly individuals and provide new insight that improve the present understanding of the metabolic mechanisms of structural brain disconnections in normal aging.


===MeSH Terms===
|keywords=* Aging
-
* Head and neck cancer
* Immune escape
* Immunosenescence
* T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017629
}}
{{medline-entry
|title=Immunological history governs human stem cell memory [[CD4]] heterogeneity via the Wnt signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041953


===Keywords===
|mesh-terms=* Aging
Brain network; Diffusion MRI; FDG-PET; Glucose metabolism; Graph theory; MRI; Normal aging
* Animals
* Antigens, CD
* CD4-Positive T-Lymphocytes
* Gene Expression Profiling
* HIV Infections
* Humans
* Immunologic Memory
* Intercellular Signaling Peptides and Proteins
* Mice
* Precursor Cells, T-Lymphoid
* Thymus Gland
* Wnt Signaling Pathway
* beta Catenin


==A Prospective Double-blind, Placebo-controlled Clinical Trial Evaluating the Efficacy of a Novel Combination of Hyaluronic Acid Serum and Antioxidant Cream for Rejuvenation of the Aging Neck.==
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010798
===Abstract===
}}
The neck is one of the most common areas affected by the aging process. A novel two product combination system composed of a serum and cream with hyaluronic acid and multiple strong antioxidants were investigated to determine their efficacy and safety in neck rejuvenation.   The objective of this prospective, randomized, double-blind, placebo-controlled clinical trial was to assess the efficacy and safety of a novel serum containing fractionated hyaluronic acid, peptides, and antioxidants for photodamage of the neck.   This was an institutional review board (IRB)-approved, randomized, double blind, placebo-controlled clinical trial involving 31 healthy subjects with moderate-to-severe neck wrinkling corresponding to at least a Grade 2 in wrinkles and score of 4 in elastosis on the Fitzpatrick-Goldman Wrinkle Scale. Twenty subjects were randomized to receive the active cream and serum system, while 11 subjects were randomized to receive the vehicles alone in serum and cream format for a course of two months.   Both active and placebo cream and serum showed improvement of wrinkles, laxity, pigmentation, erythema, dryness, and texture of the skin, and high patient satisfaction scores. Histology of one of the active serums and cream samples revealed improvement in the quality of papillary dermal collagen and increase in the number of elastic fibers in the upper dermis after treatment.  Our prospective, randomized controlled trial showed that the novel serum and cream showed improvement in skin aging on the neck, was well-tolerated by patients, and had a high degree of patient satisfaction.
{{medline-entry
|title=Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011956


===MeSH Terms===
|mesh-terms=* Anti-HIV Agents
-
* CD4 Lymphocyte Count
* Comorbidity
* Cost-Benefit Analysis
* HIV Infections
* Health Care Costs
* Humans
* Life Expectancy
* United States


===Keywords===
|full-text-url=https://sci-hub.do/10.18553/jmcp.2020.26.2.104
Aging neck; antioxidant; hyaluronic acid cream; neck rejuvenation
}}
{{medline-entry
|title=Sex Differences in People Aging With HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032279


==Sex Differences in the Complexity of Healthy Older Adults' Magnetoencephalograms.==
|mesh-terms=* Aged
===Abstract===
* Aging
The analysis of resting-state brain activity recording in magnetoencephalograms (MEGs) with new algorithms of symbolic dynamics analysis could help obtain a deeper insight into the functioning of the brain and identify potential differences between males and females. Permutation Lempel-Ziv complexity (PLZC), a recently introduced non-linear signal processing algorithm based on symbolic dynamics, was used to evaluate the complexity of MEG signals in source space. PLZC was estimated in a broad band of frequencies (2-45 Hz), as well as in narrow bands (i.e., theta (4-8 Hz), alpha (8-12 Hz), low beta (12-20 Hz), high beta (20-30 Hz), and gamma (30-45 Hz)) in a sample of 98 healthy elderly subjects (49 males, 49 female) aged 65-80 (average age of 72.71 ± 4.22 for males and 72.67 ± 4.21 for females). PLZC was significantly higher for females than males in the high beta band at posterior brain regions including the precuneus, and the parietal and occipital cortices. Further statistical analyses showed that higher complexity values over highly overlapping regions than the ones mentioned above were associated with larger hippocampal volumes only in females. These results suggest that sex differences in healthy aging can be identified from the analysis of magnetoencephalograms with novel signal processing methods.
* Alcohol Drinking
* Body Composition
* CD4 Lymphocyte Count
* CD4-CD8 Ratio
* CD4-Positive T-Lymphocytes
* Cohort Studies
* Cross-Sectional Studies
* Female
* Frailty
* HIV Infections
* Humans
* Male
* Middle Aged
* Muscle Strength
* Prospective Studies


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002259
-
}}
{{medline-entry
|title=Identification of Differentially Expressed miRNAs in the Response of Spleen [[CD4]]  T Cells to Electroacupuncture in Senescence-Accelerated Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026263


===Keywords===
|mesh-terms=* Aging
healthy aging; magnetoencephalography; permutation Lempel-Ziv complexity; sex differences; source space
* Animals
* Antagomirs
* CD4-Positive T-Lymphocytes
* Cell Differentiation
* Cytokines
* Down-Regulation
* Electroacupuncture
* Female
* Gene Regulatory Networks
* High-Throughput Nucleotide Sequencing
* Male
* Mice
* Mice, Inbred C57BL
* MicroRNAs
* Sequence Analysis, RNA
* Spleen
* Up-Regulation
|keywords=* CD4+ T cell
* Deep sequencing
* Electroacupuncture
* Immunological aging
* miRNA
|full-text-url=https://sci-hub.do/10.1007/s12013-020-00900-x
}}
{{medline-entry
|title=Thymus Involution and Intravenous Drug Abuse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000220


==Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.==
|mesh-terms=* Adolescent
===Abstract===
* Adult
Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of HSC aging. In addition, we discuss the potential mechanisms by which HSC aging is regulated.
* Aging
* Atrophy
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Calcinosis
* Case-Control Studies
* Drug Users
* Female
* Forensic Pathology
* Hepatitis C, Chronic
* Humans
* Male
* Middle Aged
* Substance Abuse, Intravenous
* Thymus Gland
* Young Adult


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1097/PAF.0000000000000530
-
}}
{{medline-entry
|title=Depletion of [[CD4]] T cells provides therapeutic benefits in aged mice after ischemic stroke.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31954116


===Keywords===
|mesh-terms=* Aging
Aging; HSCs; Replication stress
* Animals
* Behavior, Animal
* Brain Chemistry
* Brain Ischemia
* CD4-Positive T-Lymphocytes
* Chemokines
* Cytokines
* Female
* Infarction, Middle Cerebral Artery
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Stroke
* Treatment Outcome
|keywords=* Age
* CD4 T cells
* CXCL10
* Inflammation
* Stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059209
}}
{{medline-entry
|title=Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31913990


==The association between subjective health perception and lifestyle factors in Shiga prefecture, Japan: a cross-sectional study.==
|mesh-terms=* Aged
===Abstract===
* Aging
The Ministry of Health has reported that in Japan, the Shiga prefecture has the highest life expectancy. Subjective health perception is a predictive indicator of mortality. For this study, we examined the association between subjective health perception and multiple lifestyle factors. Data were obtained from the 2015 Health and Nutrition Survey in Shiga prefecture. The analytic sample comprised 6057 adults aged 20 or older. Information on subjective health perception and lifestyle behaviors was obtained from a self-administered questionnaire. As for subjective health perception, participants were divided into 2 groups: (1) Excellent or Good and (2) Average, Poor, or Very Poor. A 1-day dietary survey was also administered. The health behaviors score (HBS) was calculated based on 5 factors: consuming a healthy diet, never smoking, low-risk alcohol drinking, regular exercise, and moderate sleep duration. HBS scores ranged from 0 to 5. Multiple logistic regression was used to calculate the sex-, age- BMI- and energy intake-adjusted odds ratios (ORs) of poor subjective health across HBS, with 0 points as the reference. Among all participants, 2397 (39.6%) individuals were classified into the good subjective health group. Participants with an HBS of 3 (OR 0.59, 95% CI 0.37-0.96), 4 (OR 0.40, 95% CI 0.24-0.65) or 5 (OR 0.33, 95% CI 0.19-0.59) had a lower OR of rating themselves as being average/poor health compared with those having zero. The association with a higher HBS was remarkable (p for trend: < 0.001). Additional analyses revealed that the combinations including regular exercise were particularly associated with a lower risk of subjective average/poor health. This study showed that the higher the number of healthy lifestyle factors, the lower risk of subjective average/poor health. Combinations of healthy lifestyle factors, especially those involving exercise, suggest good subjective health for individuals living in the Shiga prefecture.
* Anti-HIV Agents
* HIV Infections
* Humans
* Middle Aged


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002266
-
}}
{{medline-entry
|title=African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31927570


===Keywords===
Diet; Lifestyle behavior; Longevity; Subjective health


==The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system.==
|keywords=* HIV
===Abstract===
* aging
Understanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this aspect of vision, which is essential for survival in a dynamic world, still remain unclear. Using optomotor responses to drifting gratings, we investigated age-related changes in motion detection of adult zebrafish (wild-type/AB-strain and ache  mutants with decreased levels of acetylcholinesterase). Our results pointed out negative optomotor responses that significantly depend on the spatial frequency and contrast level of stimulation, providing supporting evidence for the visual motion-driven aspect of this behavior mainly exhibited by adult zebrafish. Although there were no significant main effects of age and genotype, we found a significant three-way interaction between contrast level, age, and genotype. In the contrast domain, the changes in optomotor responses and thus in the detection of motion direction were age- and genotype-specific. Accordingly, these behavioral findings suggest a strong but complicated relationship between visual motion characteristics and the cholinergic system during neural aging.
* diabetes mellitus
* mitochondrial genetics
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa026
}}
{{medline-entry
|title=DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31893939


===MeSH Terms===
|mesh-terms=* Aged
-
* Aging
* Animals
* Antihypertensive Agents
* CD4-Positive T-Lymphocytes
* Cyclic AMP-Dependent Protein Kinases
* Cytokines
* Humans
* Hypertension
* Mice
* Mice, Inbred C57BL
* Nedd4 Ubiquitin Protein Ligases
* Prostaglandin D2
* Receptors, Prostaglandin
* Signal Transduction
* Sp1 Transcription Factor
* Superoxides
* T-Box Domain Proteins
* Th1 Cells
* Ubiquitination
|keywords=* D-prostanoid receptor 1
* aging
* hypertension
* lymphocyte
* prostaglandin (PG) D2
|full-text-url=https://sci-hub.do/10.1161/CIRCULATIONAHA.119.042532
}}
{{medline-entry
|title=An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885759


===Keywords===
Acetylcholine; Aging; Direction; Motion detection; Zebrafish


==Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging.==
|keywords=* accelerated aging
===Abstract===
* anti-retroviral therapy
We characterize the whole-brain N-acetyl-aspartate (WBNAA) and brain tissue fractions across the adult lifespan and test the hypothesis that, despite age-related atrophy, neuronal integrity (reflected by WBNAA) is preserved in normal aging. Two-hundred-and-seven participants: 133 cognitively intact older adults (73.6 ± 7.4 mean ± standard deviation, range: 60-90 year old) and 84 young (37.9 ± 11, range: 21-59 year old) were scanned with proton magnetic resonance spectroscopy and T -weighted MRI. Their WBNAA, fractional brain parenchyma, and gray and white matter volumes (fBPV, fGM, and fWM) were compared and modeled as functions of age and sex. Compared with young, older-adults' WBNAA was lower by ~35%, and fBPV, fGM and fWM were lower by ~10%. Linear regressions found 0.5%/year WBNAA and 0.2%/year fBPV and fGM declines, whereas fWM rose to age ~40 years, and declined thereafter. fBPV and fGM were 1.8% and 4% higher in women, with no sex decline rates difference. We conclude that contrary to our hypothesis, atrophy was accompanied by WBNAA decline. Across the entire age range, women's brains showed less atrophy than men's. Formulas to estimate WBNAA and brain tissue fractions in healthy adults are provided to help differentiate normal from abnormal aging.
* frailty
* frailty index
* geriatric syndrome
* human immunodeficiency virus (HIV)
* multimorbidity
* vulnerability
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887139
}}
{{medline-entry
|title=Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904706


===MeSH Terms===
|mesh-terms=* Adolescent
-
* Adult
* Aging
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Drug Administration Schedule
* Female
* HIV Infections
* HIV-1
* Humans
* Male
* Medication Adherence
* Viral Load
* Young Adult


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055514
Aging; Atrophy; Brain; MR imaging; MR spectroscopy; N-Acetyl-aspartate
}}
{{medline-entry
|title=Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822125


==Understanding immunosenescence and its impact on vaccination of older adults.==
===Abstract===
Older adults are more susceptible to viral and bacterial infection, and experience higher incidence and severity of infectious diseases. Although vaccination is the most logical solution in preventing infectious diseases, primary vaccine responses in individuals aged ≥65 years-old fail to generate complete protection. This is presumably attributed to immunosenescence, a term that describes functional differences associated with the immune system and natural age advancement. Both the innate and adaptive immune systems experience age-related impairments that contribute to insufficient protection following vaccination. This review addresses current knowledge of age-related changes that affect vaccine responsiveness; including the deficits in innate cell functions, dampened humoral and cell-mediated immune responses, current vaccination schedules for older adults, and concludes with potential strategies for improving vaccine efficacy specifically for this age group. Due to an age-related decline in immunity and poor vaccine responses, infectious diseases remain a burden among the aged population.


===MeSH Terms===
|keywords=* HIV
-
* aging
* frailty
* haplotypes
* mitochondria
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133433
}}
{{medline-entry
|title=Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822433


===Keywords===
Immune; Older adults; Senescence; Vaccine


==Aging in Place With a Spouse in Need: Neighborhood Cohesion and Older Adult Spouses' Physical and Mental Health.==
|keywords=* Aging
===Abstract===
* FoxN1
This study examines the association of perceived neighborhood cohesion (NC) with older adults' health and the buffering effects of NC against the negative effects of spousal caregiving on health. Data of 3329 community-living older adults living with a spouse in need of care from the Health and Retirement Study were collected at two time-points. Multiple regression analyses were computed for each of the four health outcomes. For men, NC predicted fewer depressive symptoms and better cognition. NC buffered the negative effect of providing activities of daily living (ADL) help to the wife on cognition. For women, NC predicted fewer depressive symptoms and better cognition. NC buffered the negative effect of providing ADL help to the husband on ADL difficulties. The results accentuate the importance of residency location for older adults' physical and mental health. The health benefits of NC may have more implications for older adults providing spousal care.
* Gallic acid
* Thymus
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.imbio.2019.11.005
}}
{{medline-entry
|title=Mitochondrial mass governs the extent of human T cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31788930


===MeSH Terms===
|mesh-terms=* Adenosine Triphosphate
-
* Adult
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cell Movement
* Cell Proliferation
* Cellular Senescence
* Glucose
* Glycolysis
* Humans
* Immunosenescence
* Leukocyte Common Antigens
* Microscopy, Electron, Transmission
* Middle Aged
* Mitochondria
* Rotenone
|keywords=* T cell
* aging
* metabolism
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952
}}
{{medline-entry
|title=T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785146


===Keywords===
|mesh-terms=* Adult
aging in place; caregiving; neighborhood effects; spouse caregivers
* Aged
* Aged, 80 and over
* Extracellular Vesicles
* Female
* Humans
* Immunosenescence
* Lymphocyte Activation
* Male
* Middle Aged
* T-Lymphocytes
|keywords=* T cells
* aging
* centenarians
* extracellular vesicles (EVs)
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914389
}}
{{medline-entry
|title=Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747595


==Pelvic floor muscle strength is correlated with sexual function.==
|mesh-terms=* Aging
===Abstract===
* Animals
Sexual performance is related to proprioception and pelvic floor muscle strength (PFMS). The aim of this study was to correlate sexual activity and orgasm with PFMS. A total of 140 healthy continent female were prospectively distributed into 4 groups according to age: Group 1 (G1), 30-40; Group 2 (G2), 41-50; Group 3 (G3), 51-60; Group 4 (G4), over 60 years old. Evaluated parameters were: frequency of sexual activity and orgasm achievement; body mass index (BMI) and objective evaluation of PFMS using perineometer and surface electromyography. BMI was higher in G4 compared to G1 (p=0.042). Women who reported sexual activity was significantly higher in G1 compared to G3 and G4 (94.1% vs. 66.7% and 37.5%, respectively; p=0.001). Orgasm was more frequently in G1 compared to G3 and G4 (91.2% vs. 63.9% and 28.1%, respectively; p=0.001), demonstrating that sexual activity and orgasm decrease after age 51. The duration of PFM contraction was significantly higher in women who had sexual intercourse (p=0.033) and orgasm (p=0.018). Although the frequency of sexual intercourse and orgasm may decrease with aging, a relationship between sexual activity and PFMS remains apparent, once both sexually active women and those who have orgasms showed better PFM endurance than non-sexually active ones.
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Disease Models, Animal
* Lymphocytic Choriomeningitis
* Lymphocytic choriomeningitis virus
* Mice
* MicroRNAs
|keywords=* CD8 effector T cell
* T cell repertoire
* antiviral response
* immune aging
* immunosenescence
* microRNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957231
}}
{{medline-entry
|title=Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755936


===MeSH Terms===
-


===Keywords===
|keywords=* Frascati criteria
Aging; Muscle strength dynamometer; Muscular contraction; Sexual activities
* HAND
* HIV
* aging
* neurocognitive impairment
|full-text-url=https://sci-hub.do/10.1093/cid/ciz670
}}
{{medline-entry
|title=Age-associated changes in human [[CD4]]  T cells point to mitochondrial dysfunction consequent to impaired autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707363


==The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals.==
|mesh-terms=* Adult
===Abstract===
* Aged
Aquaporins constitute a group of water channel proteins located in numerous cell types. These are pore-forming transmembrane proteins, which mediate the specific passage of water molecules through membranes. It is well-known that water homeostasis plays a crucial role in different reproductive processes, e.g., oocyte transport, hormonal secretion, completion of successful fertilization, blastocyst formation, pregnancy, and birth. Further, aquaporins are involved in the process of spermatogenesis, and they have been reported to be involved during the storage of spermatozoa. It is noteworthy that aquaporins are relevant for the physiological function of specific parts in the female reproductive system, which will be presented in detail in the first section of this review. Moreover, they are relevant in different pathologies in the female reproductive system. The contribution of aquaporins in selected reproductive disorders and aging will be summarized in the second section of this review, followed by a section dedicated to aquaporin-related proteins. Since the relevance of aquaporins for the male reproductive system has been reviewed several times in the recent past, this review aims to provide an update on the distribution and impact of aquaporins only in the female reproductive system. Therefore, this paper seeks to determine the physiological and patho-physiological relevance of aquaporins on female reproduction, and female reproductive aging.
* CD4-Positive T-Lymphocytes
* Cell Respiration
* Humans
* Immunosenescence
* Longitudinal Studies
* Mitochondria
* Mitophagy
* Young Adult
|keywords=* CD4+ T cells
* aging
* autophagy
* mitochondria
* proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874450
}}
{{medline-entry
|title=Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722210


===MeSH Terms===
|mesh-terms=* Aging
-
* CD4-Positive T-Lymphocytes
* Female
* Humans
* Influenza, Human
* Male
* Monocytes
* Sex Characteristics
* Transcriptome
|keywords=* CD4(+) T cells
* aging
* immune system
* immunology
* influenza
* meta-analysis
* monocytes
* multi-cohort analysis
* sex differences
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856718
}}
{{medline-entry
|title=Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711310


===Keywords===
aging; aquaporin; connexin; female reproductive system; gap-junctions; mammals; ovary; physiology; placenta; uterus


==The Role of Nrf2 in D-Galactose-Induced Cardiac Aging in Mice: Involvement of Oxidative Stress.==
|keywords=* ART
===Abstract===
* PLWH
Cardiac aging is the major risk factor for advanced heart disease, which is the leading cause of death in developed countries, accounting for >30% of deaths worldwide. To discover the detailed mechanism of cardiac aging and develop an effective therapeutic candidate drug to treat or delay cardiac aging. We used D-galactose to induce cardiac aging in Nrf2+/+ and Nrf2-/- mice, and then treated these mice with vehicle or the Nrf2 activator, CDDO-imidazolide (CDDO-Im). D-galactose injection significantly induced cardiac aging, cell apoptosis, and oxidative stress in Nrf2+/+ mice, all of which were further exacerbated in Nrf2-/- mice. CDDO-Im treatment can effectively weaken oxidative stress and enhance the activities of antioxidant enzymes, but CDDO-Im lost its antioxidative effect in the Nrf2-/- mice. Nrf2 activator CDDO-Im could therefore effectively protect against D-galactose-induced cardiac aging by inhibiting oxidative stress, suggesting that CDDO-Im might be a potential and promising therapeutic candidate drug to treat cardiac aging.
* aging
* multimorbidity
* quality of life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071065
}}
{{medline-entry
|title=Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31683168


===MeSH Terms===
|mesh-terms=* Aged
-
* Animals
* Cell Line, Tumor
* Cell Proliferation
* Female
* Humans
* Immunotherapy
* Mice
|keywords=* Aging
* Immune check-point molecules
* Immunosenescence
* Immunotherapy
* Myeloid derived suppressor cells
* Oral cancer
* Regulatory T cells
|full-text-url=https://sci-hub.do/10.1016/j.oraloncology.2019.104462
}}
{{medline-entry
|title=LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31641151


===Keywords===
|mesh-terms=* Adjuvants, Immunologic
CDDO-imidazolide; Cardiac aging; D-galactose; Nrf2; Oxidative stress
* Administration, Intranasal
* Aging
* Animals
* Antibodies
* Antibody Formation
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* Dose-Response Relationship, Immunologic
* Enterotoxins
* Female
* Immunity, Mucosal
* Immunization
* Inflammation
* Influenza A Virus, H1N1 Subtype
* Lung
* Lymphocyte Activation
* Lymphocyte Depletion
* Mast Cells
* Mice, Inbred C57BL
* Orthomyxoviridae Infections


==A recipe for accurate estimation of lifespan brain trajectories, distinguishing longitudinal and cohort effects.==
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805908
===Abstract===
}}
We address the problem of estimating how different parts of the brain develop and change throughout the lifespan, and how these trajectories are affected by genetic and environmental factors. Estimation of these lifespan trajectories is statistically challenging, since their shapes are typically highly nonlinear, and although true change can only be quantified by longitudinal examinations, as follow-up intervals in neuroimaging studies typically cover less than 10 % of the lifespan, use of cross-sectional information is necessary. Linear mixed models (LMMs) and structural equation models (SEMs) commonly used in longitudinal analysis rely on assumptions which are typically not met with lifespan data, in particular when the data consist of observations combined from multiple studies. While LMMs require a priori specification of a polynomial functional form, SEMs do not easily handle data with unstructured time intervals between measurements. Generalized additive mixed models (GAMMs) offer an attractive alternative, and in this paper we propose various ways of formulating GAMMs for estimation of lifespan trajectories of 12 brain regions, using a large longitudinal dataset and realistic simulation experiments. We show that GAMMs are able to more accurately fit lifespan trajectories, distinguish longitudinal and cross-sectional effects, and estimate effects of genetic and environmental exposures. Finally, we discuss and contrast questions related to lifespan research which strictly require repeated measures data and questions which can be answered with a single measurement per participant, and in the latter case, which simplifying assumptions that need to be made. The examples are accompanied with R code, providing a tutorial for researchers interested in using GAMMs.
{{medline-entry
|title=Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660382


===MeSH Terms===
-


===Keywords===
|keywords=* HIV
Aging; Cohort effects; Generalized additive mixed models; Lifespan brain research; Longitudinal analysis; MRI; R
* aging
* frailty
* metabolic syndrome
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809752
}}
{{medline-entry
|title=Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624962


==Effects of Aging Process on the Damping Performance of ZK60 Magnesium Alloys Prepared by Large Strain Rolling.==
|mesh-terms=* Aged
===Abstract===
* Aging
In this study, the effects of an aging treatment (T5) and a solution + aging treatment (T6) on the microstructure and damping properties of a ZK60 magnesium alloy prepared by large strain rolling (LSR) were studied by an optical microscope (OM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and dynamic thermomechanical analysis (DMA). The results showed that both the T5 and T6 processes had a great impact on the microstructure and damping properties of the ZK60 magnesium alloy. With the increase in aging time, the grain size was basically unchanged, and the amount of the second phase increased, resulting in a gradual decrease in the damping performance. However, compared with the damping performance of the un-aged ZK60 magnesium alloy, the damping performance of the 4 h-aged ZK60 magnesium alloy was enhanced. At the same aging time, the increase in the aging temperature promoted the precipitation of the second phase, thereby reducing the damping performance of the ZK60 magnesium alloy. It was found that the T6-treated ZK60 magnesium alloy had a larger grain size, which led to a better damping performance; in addition, the T6-treated ZK60 magnesium alloy exhibited a damping plateau, which was determined by the distribution and amount of the second phase.
* B-Lymphocyte Subsets
* Case-Control Studies
* Female
* Humans
* Male
* Middle Aged
* Osteoarthritis, Knee
* T-Lymphocyte Subsets
|keywords=* B cell
* Lymphocyte
* Osteoarthritis
* T cell
|full-text-url=https://sci-hub.do/10.1007/s10067-019-04768-y
}}
{{medline-entry
|title=Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588776


===MeSH Terms===
|mesh-terms=* Aging
-
* Anti-Retroviral Agents
* Cardiovascular Diseases
* Carotid Intima-Media Thickness
* Cross-Sectional Studies
* Depression
* Female
* HIV Infections
* Humans
* Male
* Middle Aged
* Neurocognitive Disorders
* Quality of Life
* Risk Factors
* Thailand
|keywords=* HIV
* aging
* carotid intima-media thickness
* neurocognitive
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0139
}}
{{medline-entry
|title=Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578868


===Keywords===
|mesh-terms=* Adult
ZK60 magnesium alloy; aging treatment; damping performance; second phase
* Aged
* Aging
* Anti-HIV Agents
* Antiretroviral Therapy, Highly Active
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cytokines
* Female
* Flow Cytometry
* Gene Expression
* HIV Infections
* HIV-1
* Hepatitis A Virus Cellular Receptor 2
* Humans
* Leukocytes, Mononuclear
* Male
* Middle Aged
* Young Adult
* gag Gene Products, Human Immunodeficiency Virus
|keywords=* aging
* immune checkpoint molecules
* virus suppression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862963
}}
{{medline-entry
|title=Age-related alterations in human gut [[CD4]] T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573727


==Nurse Perspectives on Urinary Incontinence in the Home Hospice Setting.==
|mesh-terms=* Adolescent
===Abstract===
* Adult
To date, no studies have characterized the impacts of urinary incontinence (UI) at the end of life (EOL) in the home hospice (HH) setting. UI is highly prevalent at the EOL and adversely affects quality of life. To characterize HH nurses' perspectives on UI in HH patients. We conducted a qualitative descriptive study of interviews between HH nurses and the study investigator. Thirty-two interviews with HH nurses were transcribed and analyzed. Nurses were mostly female, college-educated, and had several years of experience in HH nursing. We identified findings in four major themes: 1) HH nurses' definition and identification of UI, 2) the absence of formal guidelines for diagnosing UI in HH patients, 3) UI's adverse effect on HH patients and their families, and 4) the lack of standardized guidelines for the management of UI in the HH setting. We found that there was a general lack of clarity on the subtypes of UI and no standardized guidelines for management of UI in the HH setting. Nurses reported that UI was bothersome to HH patients and their caregivers, citing patient discomfort, loss of dignity, and additional labor burden as reasons for this. Management strategies for UI lacked standardization. UI is a prevalent and debilitating condition in HH patients. There is a need for studies to further characterize the impacts of UI on HH patients and their caregivers. Formal training on UI subtypes and management is needed to facilitate proper documentation, research, and improve patient outcomes.
* Age Factors
* Aged
* Aged, 80 and over
* CD4-Positive T-Lymphocytes
* Female
* Gastrointestinal Microbiome
* Humans
* Interleukin-17
* Intestinal Mucosa
* Male
* Middle Aged
* Phenotype
* Th1 Cells
* Th17 Cells
* Young Adult
|keywords=* T helper cells
* aging
* gut
* human
|full-text-url=https://sci-hub.do/10.1002/JLB.5A0919-177RR
}}
{{medline-entry
|title=Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532902


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Anti-Retroviral Agents
* Cross-Sectional Studies
* Darunavir
* Emtricitabine
* Female
* HIV Infections
* Humans
* Logistic Models
* Male
* Middle Aged
* RNA, Viral
* Raltegravir Potassium
* Ritonavir
* Telomere
* Tenofovir
|keywords=* HIV infection
* aging
* immunosenescence
* telomere length
* viral load
|full-text-url=https://sci-hub.do/10.1111/hiv.12791
}}
{{medline-entry
|title=Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497023


===Keywords===
|mesh-terms=* Adult
Urinary incontinence; end of life; geriatrics; home hospice; nursing
* Cell Differentiation
* Cell Proliferation
* Cell Survival
* Humans
* T-Lymphocytes
* Telomerase
|keywords=* T cell subsets
* T lymphocytes
* aging
* alternative splicing
* differentiation
* hTERT
* proliferation
* telomerase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712505
}}
{{medline-entry
|title=Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452382


==Female-biased effects of aging on a chimeric hemagglutinin stalk-based universal influenza virus vaccine in mice.==
|mesh-terms=* Aged
===Abstract===
* Aging
To determine if biological sex and age intersect to affect universal influenza vaccine-induced immunity, adult and aged male and female C57BL/6 mice were sequentially immunized with a chimeric-hemagglutinin (cHA) stalk-based H1 vaccine. Adult mice developed greater quantity and quality of H1-stalk antibodies, that were more cross-reactive with other group 1, but not group 2, influenza viruses, than aged mice. The vaccine did not induce neutralizing or hemagglutination inhibition antibodies, but rather antibody-dependent cellular cytotoxicity, which was greater in adult than aged mice. Vaccinated adult mice were better protected than aged mice after challenge with 2009 H1N1 virus, experiencing less morbidity and having lower pulmonary virus titers. The age-associated decline in immunity and protection was consistently greater among females than males, with the reduction in immunity and protection for aged as compared with adult females often being the sole comparison driving the overall age-associated significant differences. The age-associated reduction in stalk-based immunity in females was not, however, associated with changes in estradiol. To determine if the better antibodies in adults could be utilized to protect aged mice, serum was passively transferred from vaccinated adult mice into naïve sex-matched aged mice. Even with transferred serum from young adult mice, aged females still suffered greater morbidity than aged males. These data suggest there are sex-dependent effects of aging on cHA-based universal influenza virus vaccine-induced immunity that cannot be reversed through transfer of serum from young animals. The lack of consideration of sex-specific effects of aging on immunity could hinder efforts toward universal vaccines.
* Brazil
* CD4 Lymphocyte Count
* Cardiovascular Diseases
* Comorbidity
* Diabetes Mellitus
* Female
* HIV Infections
* Humans
* Life Expectancy
* Male
* Middle Aged
* Neoplasms
* Polypharmacy
|keywords=* Brazil
* HIV
* aging
* noncommunicable diseases
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0069
}}
{{medline-entry
|title=Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468979


===MeSH Terms===
|mesh-terms=* Adult
-
* African Americans
* Aging
* CD4 Lymphocyte Count
* Cohort Studies
* Female
* Glycated Hemoglobin A
* HIV Infections
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Neurocognitive Disorders
* Odds Ratio
* RNA, Viral
* Risk Factors
* Walking Speed
|keywords=* aging
* gait speed
* hemoglobin A1C
* neurocognitive impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862955
}}
{{medline-entry
|title=Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468993


===Keywords===
|mesh-terms=* Adult
Aging; Estradiol; Flu vaccine; Influenza A virus; Sex difference; Testosterone
* Age Factors
* Aged
* Anti-HIV Agents
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Comorbidity
* Cost of Illness
* Cross-Sectional Studies
* Diabetes Mellitus
* Female
* HIV Infections
* Humans
* Hypertension
* Malawi
* Male
* Middle Aged
* Noncommunicable Diseases
* Odds Ratio
* Prevalence
* Retrospective Studies
* Risk Factors
|keywords=* HIV infection
* Malawi
* aging
* noncommunicable diseases
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0125
}}
{{medline-entry
|title=Aging promotes reorganization of the [[CD4]] T cell landscape toward extreme regulatory and effector phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457092


==Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.==
|mesh-terms=* Aging
===Abstract===
* Animals
Aging is characterized by reduced immune responses, a process known as immunosenescence. Shortly after their generation, antigen-experienced adaptive immune cells, such as CD8  and CD4  T cells, migrate into the bone marrow (BM), in which they can be maintained for long periods of time within survival niches. Interestingly, we recently observed how oxidative stress may negatively support the maintenance of immunological memory in the BM in old age. To assess whether the generation and maintenance of immunological memory could be improved by scavenging oxygen radicals, we vaccinated 18-months (old) and 3-weeks (young) mice with alum-OVA, in the presence/absence of antioxidants vitamin C (Vc) and/or N-acetylcysteine (NAC). To monitor the phenotype of the immune cell population, blood was withdrawn at several time-points, and BM and spleen were harvested 91 days after the first alum-OVA dose. Only in old mice, memory T cell commitment was boosted with some antioxidant treatments. In addition, oxidative stress and the expression of pro-inflammatory molecules decreased in old mice. Finally, changes in the phenotype of dendritic cells, important regulators of T cell activation, were additionally observed. Taken together, our data show that the generation and maintenance of memory T cells in old age may be improved by targeting oxidative stress.
* CD4-Positive T-Lymphocytes
* High-Throughput Nucleotide Sequencing
* Immunomodulation
* Mice
* Phenotype
* Sequence Analysis, RNA
* Single-Cell Analysis
* T-Lymphocyte Subsets


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703865
-
}}
{{medline-entry
|title=Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448551


===Keywords===
|mesh-terms=* Acquired Immunodeficiency Syndrome
NAC; T cells; aging; antioxidants; immunosenescence; vaccination; vitamin C
* Adult
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Cardiovascular Diseases
* Diabetes Mellitus
* Diagnostic Screening Programs
* Female
* HIV Infections
* HIV-1
* Haiti
* Humans
* Hypercholesterolemia
* Hypertension
* Male
* Middle Aged
* Obesity
* Prevalence
* Retrospective Studies
* Risk Factors
* Smoking
* Survivors
|keywords=* HIV
* aging
* cardiovascular disease
* hypertension
* risk assessment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896990
}}
==CD44==


==Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.==
{{medline-entry
===Abstract===
|title=Hyaluronan goes to great length.
Although the Klotho gene is recognized as an aging-suppressor gene, the clinical significance of its soluble product, soluble Klotho, in coronary artery disease (CAD) has not been completely determined. The relationship between soluble Klotho and coronary artery calcification (CAC) was investigated in patients with stable CAD. CAC in culprit lesions was analyzed in 75 non-dialysis patients with stable CAD who were scheduled for percutaneous coronary intervention (PCI) following intravascular ultrasound (IVUS). The main outcome measure was the calcium index (CalcIndex), a volumetric IVUS-derived measure of total calcification per culprit lesion. A low CalcIndex was defined as a first-quartile calcium index (<0.042). Patients were divided into two groups according to the median serum Klotho value: low Klotho (n = 37, ≤460 pg/mL) and high Klotho (n = 38, >460 pg/mL). The CalcIndex was significantly lower in patients with high than with low Klotho. Patients with high Klotho had a significantly higher prevalence of a low CalcIndex than those with low Klotho. The number of angiographic moderate-severe CACs in whole coronary arteries was significantly decreased in patients with high Klotho compared to low Klotho. Serum Klotho levels correlated significantly and inversely with the CalcIndex. This relationship was pronounced in patients with estimated glomerular filtration rate <60 mL/min/1.73 m . Logistic regression analysis showed that high Klotho was associated with a low CalcIndex independent of classical coronary risk factors and markers of mineral metabolism. High serum soluble Klotho levels are associated with a low degree of CAC in non-dialysis, stable CAD patients treated by PCI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32908962


===MeSH Terms===
-


===Keywords===
|keywords=* aging
Aging; Coronary artery calcification; Intravascular ultrasound; Klotho
* hyaluronan
* longevity
* naked mole rat
* very high molecular weight hyaluronan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453635
}}
{{medline-entry
|title=Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32398747


==Psychological Distress After Covid-19 Recovery: Reciprocal Effects With Temperament and Emotional Dysregulation. An Exploratory Study of Patients Over 60 Years of Age Assessed in a Post-acute Care Service.==
|mesh-terms=* Animals
===Abstract===
* Apoptosis
To study the long-term psychological effects of Covid-19 disease, we recruited 61 patients older than 60 years of age and administered the Kessler questionnaire K10 to assess psychological distress and classify them according to mental health risk groups. Patients' affective temperaments were assessed with the 39-item form of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS-A-39) and emotional dysregulation with the Difficulties in Emotion Regulation Scale (DERS). Patients were divided in two samples according to their scores on the K10, i.e., a high likelihood of psychological distress group ([i]N[/i] = 18) and a low likelihood of psychological distress group ([i]N[/i] = 43). The two groups differed on their gender composition, in that more women ([i]N[/i] = 11) were in the former and more men in the latter ([i]N[/i] = 29) (χ  = 4.28; [i]p[/i] = 0.039). The high likelihood of psychological distress group scored higher on the Cyclothymic (3.39 ± 3.45 vs. 0.93 ± 1.08, [i]p[/i] < 0.001) and the Depressive (2.28 ± 2.82 vs. 0.65 ± 1.09, [i]p[/i] = 0.01) affective temperaments of the TEMPS and on the lack of Impulse control (12.67 ± 4.04 vs. 9.63 ± 3.14, [i]p[/i] = 0.003) and lack of Clarity (15.00 ± 5.56 vs. 9.85 ± 4.67, [i]p[/i] = 0.004) scales of the DERS. Our results show that having had Covid-19 may be related with high likelihood for psychological distress in advanced-age people and this may in turn be associated with impaired emotional regulation and higher scores on depressive and cyclothymic temperaments.
* Cell Cycle Checkpoints
* Cell Line
* Cytoprotection
* Gene Expression Regulation
* Gene Knockout Techniques
* Humans
* Hyaluronan Receptors
* Hyaluronic Acid
* Longevity
* Mice
* Mole Rats
* Molecular Weight
* Primary Cell Culture
* Protein Interaction Maps
* RNA-Seq
* Signal Transduction
* Species Specificity
* Stress, Physiological
* Tumor Suppressor Protein p53


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217962
-
}}
{{medline-entry
|title=Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32321631


===Keywords===
COVID-19; affective temperaments; aging; emotional dysregulation; nasal swab; nasopharyngeal swab; psychological distress


==The cellular mechanobiology of aging: from biology to mechanics.==
|keywords=* Aging
===Abstract===
* Articular cartilage
Aging is a chronic, complicated process that leads to degenerative physical and biological changes in living organisms. Aging is associated with permanent, gradual physiological cellular decay that affects all aspects of cellular mechanobiological features, including cellular cytoskeleton structures, mechanosensitive signaling pathways, and forces in the cell, as well as the cell's ability to sense and adapt to extracellular biomechanical signals in the tissue environment through mechanotransduction. These mechanobiological changes in cells are directly or indirectly responsible for dysfunctions and diseases in various organ systems, including the cardiovascular, musculoskeletal, skin, and immune systems. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establishes mechanistic frameworks to understand the mechanobiological effects of aging on disease progression and to develop new strategies for halting and reversing the aging process. Our review also highlights the recent development of novel bioengineering approaches for studying the key mechanobiological mechanisms in aging.
* Osteoarthritis
* Plasticity
* Progenitor cells
|full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2020.103732
}}
{{medline-entry
|title=Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32289288


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Dry Eye Syndromes
* Female
* Immunologic Memory
* Mice
* Mice, Inbred C57BL
* Th17 Cells


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369573
aging; cytoskeleton; force; mechanobiology; mechanotransduction
}}
{{medline-entry
|title=Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054990


==Dysregulation of leukocyte trafficking in ageing: Causal factors and possible corrective therapies.==
|mesh-terms=* Animals
===Abstract===
* B-Lymphocytes
Ageing is a universal biological phenomenon that is accompanied by the development of chronic, low-grade inflammation and remodelling of the immune system resulting in compromised immune function. In this review, we explore how the trafficking of innate and adaptive immune cells under homeostatic and inflammatory conditions is dysregulated in ageing. We particularly highlight the age-related changes in the expression of adhesion molecules and chemokine receptor/ligands, and the accumulation of senescent cells that drive modulated leukocyte trafficking. These age-related changes to leukocyte trafficking are multifactorial and specific to leukocyte subsets, tissue, type of vascular beds, and inflammatory status. However, dysregulated leukocyte trafficking ultimately affects immune responses in older adults. We therefore go on to discuss approved drugs, including anti-integrins, anti-chemokines and statins, as well as novel therapeutics that may be used to target dysregulated leukocyte trafficking in ageing, improve immune responses and delay the onset of age-related diseases.
* Cellular Senescence
* Circadian Rhythm
* Disease Models, Animal
* Humans
* Hyaluronan Receptors
* Inflammation
* Jet Lag Syndrome
* Longevity
* Mice
* Programmed Cell Death 1 Receptor
* Sequence Analysis, RNA
* T-Lymphocytes


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018741
-
}}
{{medline-entry
|title=Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31621149


===Keywords===
|mesh-terms=* Animals
Leukocyte; ageing; inflammageing; senescence; therapies; trafficking
* CD4-Positive T-Lymphocytes
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Cytokines
* Hyaluronan Receptors
* Mice
* Mice, Inbred C57BL
* Phenotype
* Programmed Cell Death 1 Receptor
* Proteasome Endopeptidase Complex
* Receptors, Antigen, T-Cell
* Signal Transduction
|keywords=* T cell receptor signal
* T cell senescence
* aging
* proteasome
|full-text-url=https://sci-hub.do/10.1111/gtc.12728
}}
==CD47==


==Adaptation of the comprehensive geriatric assessment to a virtual delivery format.==
{{medline-entry
===Abstract===
|title=Aging-associated changes in [[CD47]] arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.
---
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866348


===MeSH Terms===
-


===Keywords===
|keywords=* CD47
geriatric assessment; geriatrics; telehealth; telemedicine
* aging
* dSTORM
* red blood cells
* thrombospondin-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576236
}}
{{medline-entry
|title=[[CD47]] Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679764


==Alkaline ceramidase family: The first two decades.==
===Abstract===
Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid. Ceramidases are classified into the acid, neutral, and alkaline ceramidase subtypes according to the pH optima for their catalytic activity. YPC1 and YDC1 were the first alkaline ceramidase genes to be identified and cloned from the yeast Saccharomyces cerevisiae two decades ago. Subsequently, alkaline ceramidase genes were identified from other species, including one Drosophila melanogaster ACER gene (Dacer), one Arabidopsis thaliana ACER gene (AtACER), three Mus musculus ACER genes (Acer1, Acer2, and Acer3), and three Homo sapiens ACER genes (ACER1, ACER2, and ACER3). The protein products of these genes constitute a large protein family, termed the alkaline ceramidase (ACER) family. All the biochemically characterized members of the ACER family are integral membrane proteins with seven transmembrane segments in the Golgi complex or endoplasmic reticulum, and they each have unique substrate specificity. An increasing number of studies suggest that the ACER family has diverse roles in regulating sphingolipid metabolism and biological processes. Here we discuss the discovery of the ACER family, the biochemical properties, structures, and catalytic mechanisms of its members, and its role in regulating sphingolipid metabolism and biological processes in yeast, insects, plants, and mammals.


===MeSH Terms===
|keywords=* CD47
-
* aging
* angiogenesis
* blood flow
* endothelial cells
* glucose homeostasis
* metabolism
* self-renewal
* thrombospondin-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407670
}}
{{medline-entry
|title=Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused [[CD47]]-SIRPα Expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645996


===Keywords===
Aging; Alkaline ceramidase; Cancer; Inflammation; Neurodegeneration; Placenta; Reproduction; Skin; Sphingolipids; Stress response


==Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.==
|keywords=* CD47
===Abstract===
* T cell exhaustion
Intervertebral disc degeneration (IDD) represents major cause of low back pain. Quercetin (QUE) is one of the approved senolytic agents. In this study, we evaluated the protective effects of QUE on IDD development and its underlying mechanism. Effects of senolytic agent QUE on the viability of nucleus pulposus cells (NPCs) were measured by CCK-8 assays and EdU staining. The senescence associated secreted phenotype (SASP) factors expressions were measured by qPCR, western blot, and ELISA; and NF-κB pathway was detected by immunofluorescence and western blot. Molecular docking was applied to predict the interacting protein of QUE; while Nrf2 was knocked down by siRNAs to confirm its role in QUE regulated senescence phenotype. X-ray, MRI, Hematoxylin-Eosin and Safranin O-Fast green staining were performed to evaluate the therapeutic effects of QUE on IDD in the puncture-induced rat model. In in vitro experiments, QUE inhibited SASP factors expression and senescence phenotype in IL-1β-treated NPCs. Mechanistically, QUE suppressed IL-1β induced activation of the NF-κB pathway cascades; it was also demonstrated in molecular docking and knock down studies that QUE might bind to Keap1-Nrf2 complex to suppress NF-κB pathway. In vivo, QUE ameliorated the IDD process in the puncture-induced rat model. Together the present work suggests that QUE inhibits SASP factors expression and senescence phenotype in NPCs and ameliorates the progression of IDD via the Nrf2/NF-κB axis, which supports senolytic agent QUE as a potential therapeutic agent for the treatment of IDD.
* T cell senescence
* draining lymph nodes
* macrophage checkpoint
* neoadjuvant chemotherapy
* pancreatic ductal adenocarcinoma
* signal regulatory protein alpha (SIRPα)
* spatial heterogeneity
* tumor microenvironment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408661
}}
==CD5==


===MeSH Terms===
{{medline-entry
-
|title=Comparative proteomic analysis identifies biomarkers for renal aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33159023


===Keywords===
Intervertebral disc degeneration; NF-κB pathway; Nrf2; Quercetin; Senescence


==[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.==
|keywords=* NMN
===Abstract===
* biomarkers
Aging processes affect the brain in many ways, ranging from cellular to functional levels which lead to cognitive decline and increased oxidative stress. The aim of this study was to investigate the potentials of [i]Lactobacillus plantarum[/i] DR7 on brain health including cognitive and memory functions during aging and the impacts of high fat diet during a 12-week period. Male Sprague-Dawley rats were separated into six groups: (1) young animals on normal diet (ND, (2) young animals on a high fat diet (HFD), (3) aged animals on ND, (4) aged animals on HFD, (5) aged animals on HFD and [i]L. plantarum[/i] DR7 (10  cfu/day) and (6) aged animals receiving HFD and lovastatin. To induce ageing, all rats in group 3 to 6 were injected sub-cutaneously at 600 mg/kg/day of D-galactose daily. The administration of DR7 has reduced anxiety accompanied by enhanced memory during behavioural assessments in aged-HFD rats ([i]P[/i]<0.05). Hippocampal concentration of all three pro-inflammatory cytokines were increased during aging but reduced upon administration of both statin and DR7. Expressions of hippocampal neurotransmitters and apoptosis genes showed reduced expressions of indoleamine dioxygenase and P53 accompanied by increased expression of TPH1 in aged- HFD rats administered with DR7, indicating potential effects of DR7 along the pathways of serotonin and oxidative senescence. This study provided an insight into potentials of [i]L. plantarum[/i] DR7 as a prospective dietary strategy to improve cognitive functions during aging. This study provided an insight into potentials of [i]L. plantarum[/i] DR7 as a prospective dietary strategy to improve cognitive functions during aging.
* glutathionylation
* proteomics
* renal aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695359
}}
==CD63==


===MeSH Terms===
{{medline-entry
-
|title=Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31960578


===Keywords===
Lactobacillus spp.; aging; brain


==Investigation on Microstructures and Mechanical Properties of Isotactic Polypropylene Parts Fabricated by Different Process Conditions with Different Aging Periods.==
|keywords=* aging
===Abstract===
* extracellular vesicles
Polymeric parts have been increasingly used in various engineering fields. The performance of polymeric parts is significantly affected by working-environment-induced aging. In this paper, an ultrasonic-vibration-assisted injection molding system was designed and utilized to fabricate polymeric parts from isotactic polypropylene (iPP) using different processing conditions. The natural aging experiments were performed to age the fabricated iPP parts for one year. The effects of key process parameters as well as ultrasound power on the microstructures and the mechanical properties of the iPP parts after aging were systematically investigated using X-ray diffraction analysis, Fourier transform infrared analysis, scanning electron microscope imaging, and tensile testing. It is found that both the microstructures and the tensile strength of the iPP parts deteriorate with the increasing aging time. In addition, the crystallinity and the tensile strength decrease with the increasing melt temperature but increase with the increasing mold temperature in a given range and holding pressure. The increase in ultrasound power leads to an increase in crystallinity. However, when the ultrasound power is over 200 W, the tensile strength of the aged iPP parts decreases, which indicates that high ultrasound power may not form optimal condensed microstructures with excellent anti-aging capacity.
* microRNA
* plasma
* senescence
* senolytic
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059145
}}
==CD68==


===MeSH Terms===
{{medline-entry
-
|title=Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32422127


===Keywords===
condensed microstructures; natural aging experiments; process parameters; tensile strength; ultrasound vibration


==The Epidemiological Characteristics of Late-Onset Hypogonadism in Chinese Middle-Aged and Elderly Men: Two Cross-Sectional Studies in the Same Community.==
|keywords=* Aging
===Abstract===
* Hippocampus
The purpose of this study was to investigate the prevalence and epidemiological characteristics of late-onset hypogonadism (LOH) in middle-aged and elderly Chinese men. Two cross-sectional studies were conducted at 5-year intervals in community-dwelling men living in the same area. A total of 1472 (Study 1, S1) and 944 (Study 2, S2) men aged 40-69 years old were recruited as subjects. Subjects were evaluated through combining serum reproductive hormone levels with the Androgen Deficiency in Aging Males (ADAM) questionnaire and the Aging Males' Symptoms (AMS) scale. A significant difference was found in mean testosterone deficiency (TD) prevalence between S1 and S2, using either serum total testosterone (TT; 14.02% vs. 6.36%) or serum calculated free testosterone (cFT; 43.69% vs. 16.53%) cutoff values. According to the S1 or S2 data, the mean prevalence of LOH was 37.85%/15.47% in the positive ADAM test and 15.42%/9.43% in the positive AMS test ([i]p[/i] < .01). According to classifications of TD based on gonadal status, the prevalence of secondary TD (27.34%) was higher than the primary (16.36%) and compensated (15.42%) TD in S1 ([i]p[/i] < .01). However, there were significant differences among the prevalence of primary (6.89%), secondary (9.64%), and compensated (27.65%) TD in S2 ([i]p[/i] < .05). Different types of testosterone levels, TD cutoff values, and questionnaires influenced the prevalence of TD and LOH. The serum FT cutoff value was an optimal threshold for evaluating and diagnosing TD and LOH, whose prevalence increased gradually with male aging.
* Insulin
* Memory
* Microglia
* Neuroinflammation
|full-text-url=https://sci-hub.do/10.1016/j.brainres.2020.146884
}}
{{medline-entry
|title=Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310825


===MeSH Terms===
-


===Keywords===
|keywords=* DNA methyltransferase 1 (DNMT1)
aging; epidemiology; hypogonadism; male; prevalence; testosterone
* aging
* lumbar disc degeneration (LDD)
* macrophage polarization
* transforming growth factor beta 1 (TGFβ1)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202517
}}
{{medline-entry
|title=Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200310


==Role of nutraceuticals in cognition during aging and related disorders.==
|mesh-terms=* Antigens, CD
===Abstract===
* Antigens, Differentiation, Myelomonocytic
Cognitive abilities are compromised with advancing age posing a great risk for the development of dementia and other related brain disorders. Genetic susceptibility as well as environmental exposures determine the fate of cognitive aging and its transition to pathological states. Emerging epidemiological and observational studies have revealed the importance of lifestyle factors including dietary patterns and nutritional intake in the maintenance of cognitive health and reducing the risk of neurodegenerative disorders. In this context, nutraceutical interventions have gained considerable attention in preventing age-related cognitive deficits and counteracting pathological processes. Nutraceuticals include dietary plants and derivatives, food supplements and processed foods with nutritional and pharmaceutical values. The present review highlights the importance of nutraceuticals in attenuating cognitive aging and its progression to dementia, with specific emphasis on chemical constituents, neurocognitive properties and mechanism of action.
* Cellular Senescence
* Child
* Germinal Center
* Humans
* Hypertrophy
* Macrophages
* Palatine Tonsil
* Recurrence
* Tonsillectomy
* Tonsillitis
|keywords=* Cellular senescence
* Recurrent tonsillitis
* Tonsillar hypertrophy
|full-text-url=https://sci-hub.do/10.1016/j.ijporl.2020.110004
}}
{{medline-entry
|title=Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31695564


===MeSH Terms===
-


===Keywords===
|keywords=* Cellular senescence
Aging; Cognition; Dementia; Dietary supplements; Nutrition; Phytochemicals
* Endurance
* Ergogenic aid
* Inflammation
* Macrophage
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823780
}}
{{medline-entry
|title=Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448552


==The proteasome: friend and foe of mitochondrial biogenesis.==
|mesh-terms=* Actins
===Abstract===
* Animals
Most mitochondrial proteins are synthesized in the cytosol and subsequently translocated as unfolded polypeptides into mitochondria. Cytosolic chaperones maintain precursor proteins in an import-competent state. This post-translational import reaction is under surveillance of the cytosolic ubiquitin-proteasome system, which carries out several distinguishable activities. On the one hand, the proteasome degrades nonproductive protein precursors from the cytosol and nucleus, import intermediates that are stuck in mitochondrial translocases, and misfolded or damaged proteins from the outer membrane and the intermembrane space. These surveillance activities of the proteasome are essential for mitochondrial functionality, as well as cellular fitness and survival. On the other hand, the proteasome competes with mitochondria for nonimported cytosolic precursor proteins, which can compromise mitochondrial biogenesis. In order to balance the positive and negative effects of the cytosolic protein quality control system on mitochondria, mitochondrial import efficiency directly regulates the capacity of the proteasome via transcription factor Rpn4 in yeast and nuclear respiratory factor (Nrf) 1 and 2 in animal cells. In this review, we provide a thorough overview of how the proteasome regulates mitochondrial biogenesis.
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Cell Movement
* Fibroblasts
* Granulation Tissue
* Immunohistochemistry
* Macrophages
* Models, Animal
* Neovascularization, Physiologic
* RNA, Messenger
* Rats, Wistar
* Re-Epithelialization
* Skin
* Time Factors
* Transforming Growth Factor beta1
* Vascular Endothelial Growth Factor A
* Wound Healing
* Wounds and Injuries
|keywords=* TGFb1
* VEGF
* gene expression
* immunohistochemistry
* wound aging
|full-text-url=https://sci-hub.do/10.1111/iwj.13206
}}
==CD80==


===MeSH Terms===
{{medline-entry
-
|title=The aging common marmoset's immune system: From junior to senior.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246726


===Keywords===
|mesh-terms=* Aging
Rpn4; aging; mitochondria; mitochondria-associated degradation; mitoprotein-induced stress response; proteasome; protein degradation; protein quality control; ubiquitin
* Animals
* CD4-CD8 Ratio
* Callithrix
* Female
* Flow Cytometry
* Immune System
* Longevity
* Male
* Models, Animal
* Sex Factors
|keywords=* aging
* common marmoset
* immune system
* immunosenescence
* innate and adaptive immunity
* sex
|full-text-url=https://sci-hub.do/10.1002/ajp.23128
}}
==CD81==


==Epidemiology of geriatric trauma patients in Norway: A nationwide analysis of Norwegian Trauma Registry data, 2015-2018. A retrospective cohort study.==
{{medline-entry
===Abstract===
|title=Ovarian aging increases small extracellular vesicle [[CD81]] release in human follicular fluid and influences miRNA profiles.
Geriatric patients have a high risk of poor outcomes after trauma and is a rapid-increasing group within the trauma population. Given the need to ensure that the trauma system is targeted, efficient, accessible, safe and responsive to all age groups the aim of the present study was to explore the epidemiology and characteristics of the Norwegian geriatric trauma population and assess differences between age groups within a national trauma system. This retrospective analysis is based on data from the Norwegian Trauma Registry (2015-2018). Injury severity was scaled using the Abbreviated Injury Scale (AIS), and the New Injury Severity Score (NISS). Trauma patients 16 years or older with NISS ≥9 were included, dichotomized into age groups 16-64 years (Group 1, G1) and ≥65 years (Group 2, G2). The groups were compared with respect to differences in demographics, injury characteristics, management and outcome. Descriptive statistics and relevant parametric and non-parametric tests were used. Geriatric patients proved to be at risk of sustaining severe injuries. Low-energy falls predominated in G2, and the AIS body regions 'Head' and 'Pelvis and lower extremities' were most frequently injured. Crude 30-day mortality was higher in G2 compared to G1 (G1: 2.9 vs. G2: 13.6%, P<0.01) and the trauma team activation (TTA) rate was lower (G1: 90 vs. G2: 73%, P<0.01). A lower proportion of geriatric patients were treated by a physician prehospitally (G1: 30 vs. G2: 18%, [NISS 15-24], P<0.01) and transported by air-ambulance (G1: 24 vs. G2: 14%, [NISS 15-24], P<0.01). Median time from alarm to hospital admission was longer for geriatric patients (G1: 71 vs. G2: 78 min [NISS 15-24], P<0.01), except for the most severely injured patients (NISS≥25). In this nationwide study comparing adult and geriatric trauma patients, geriatric patients were found to have a higher mortality, receive less frequently advanced prehospital treatment and transportation, and a lower TTA rate. This is surprising in the setting of a Nordic country with free access to publicly funded emergency services, a nationally implemented trauma system with requirements to pre- and in-hospital services and a national trauma registry with high individual level coverage from all trauma-receiving hospitals. Further exploration and a deeper understanding of these differences is warranted.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554857


===MeSH Terms===
-


===Keywords===
|keywords=* extracellular vesicles
Aging; Elderly; Epidemiology; Geriatric; Injury severity score; Major trauma; Multiple trauma; Older adults; Quality of health care; Trauma registries; Traumatic
* follicular fluid
* microRNAs
* reproductive aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343446
}}
{{medline-entry
|title=Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326435


==Cognitive decline in older adults with epilepsy: The Cardiovascular Health Study.==
===Abstract===
Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age-related cognitive change remain unclear. We sought to estimate and compare rates of cognitive decline in older adults with and without epilepsy. The Cardiovascular Health Study is a population-based longitudinal cohort study of 5888 US adults aged 65+. Cognitive function was assessed annually with Modified Mini-Mental State Exam (3MS) and Digit Symbol Substitution Test (DSST). We used linear mixed models to estimate average rates of decline in 3MS and DSST scores by epilepsy status (prevalent, incident, or no epilepsy), adjusted for risk factors associated with cognitive decline. The rate of decline in 3MS was significantly faster in prevalent epilepsy (P < .001) and after incident epilepsy (P = .002) compared with no epilepsy. Prevalent epilepsy and apolipoprotein E gene (APOE) ε4 (ApoE4) had a synergistic interaction, whereby prevalent epilepsy and ApoE4 together were associated with 1.51 points faster annual decline in 3MS than would be expected if prevalent epilepsy and ApoE4 did not interact (P < .001). Older adults with prevalent epilepsy had a significantly lower initial DSST score and faster rate of decline compared to those with no epilepsy (P < .001). Faster decline in global cognitive ability seen in this study validates concerns of patients. ApoE4 allele status was an effect modifier of the relationship between cognitive decline and prevalent epilepsy. Further research is warranted to explore biological mechanisms and possible interventions to mitigate cognitive decline.


===MeSH Terms===
|keywords=* aging
-
* biomarkers
* exosomes
* mitochondrial dynamics
* mitochondrial quality control
* mitochondrial-derived vesicles (MDVs)
* mitochondrial-lysosomal axis
* mitophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227017
}}
{{medline-entry
|title=Increased production of functional small extracellular vesicles in senescent endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101370


===Keywords===
all epilepsy/seizures; cognitive aging; cohort studies; natural history studies (prognosis)


==The role of cap-dependent translation in aged-related changes in neuroimmunity and affective behaviors.==
|keywords=* endothelium
===Abstract===
* exosomes
Translation regulation in the context of aged-associated inflammation and behavioral impairments is not well characterized. Aged individuals experience lower life quality due to behavioral impairments. In this study, we used young and aged transgenic mice that are unable to activate the cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E) to examine the role of protein translation control in aging, memory, depression, and anxiety. To determine how products of cap-dependent translation play a permissive role in aged-associated inflammation, we assessed levels of pro-inflammatory cytokines in various brain regions involved in the above-mentioned behaviors. We found that functional eIF4E is not necessary for age-related deficits in spatial and short-term memory but is important for depressive and anxiety-like behavior and this is correlated with pro-inflammatory cytokines in discrete brain regions. Thus, we have begun to elucidate a role for eIF4E phosphorylation in the context of aged-related behavioral impairments and chronic low-grade inflammation that may help identify novel immune modulators for therapeutic targets and decrease the burden of self-care among the geriatric population.
* extracellular vesicles
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176858
}}
==CDA==


===MeSH Terms===
{{medline-entry
-
|title=Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771483


===Keywords===
|mesh-terms=* Aged
Aging; Anxiety; Cognition; Depression; Inflammation; eIF4E
* Aged, 80 and over
* China
* Cross-Sectional Studies
* England
* Female
* Health Behavior
* Health Status Disparities
* Humans
* Longevity
* Male
* Mexico
* Middle Aged
* Regression Analysis
* Self Report
* Sex Factors
* Social Class
* Social Welfare
* United States
|keywords=* Cumulative dis/advantage
* cross-national study
* health retirement study
* welfare state theory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367435
}}
{{medline-entry
|title=Does numerical similarity alter age-related distractibility in working memory?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31483830


==Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells.==
|mesh-terms=* Adult
===Abstract===
* Aged
Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life, replenishment largely derives from homeostatic proliferation of existing naïve and memory T cell populations. However, while the subpopulation composition of CD4 T cells is relatively stable, the CD8 T cell compartment undergoes more drastic changes with loss of naïve CD8 T cells and accumulation of effector T cells, suggesting that CD4 T cells are more resilient to resist age-associated changes. To determine the epigenetic basis for these differences in behaviors, we compared chromatin accessibility maps of CD4 and CD8 T cell subsets from young and old individuals and related the results to the expressed transcriptome. The dominant age-associated signatures resembled hallmarks of differentiation, which were more pronounced for CD8 naïve and memory than the corresponding CD4 T cell subsets, indicating that CD8 T cells are less able to keep cellular quiescence upon homeostatic proliferation. In parallel, CD8 T cells from old adults, irrespective of their differentiation state, displayed greater reduced accessibility to genes of basic cell biological function, including genes encoding ribosomal proteins. One possible mechanism is the reduced expression of the transcription factors YY1 and NRF1. Our data suggest that chromatin accessibility signatures can be identified that distinguish CD4 and CD8 T cells from old adults and that may confer the higher resilience of CD4 T cells to aging.
* Aging
* Alpha Rhythm
* Attention
* Evoked Potentials
* Female
* Healthy Volunteers
* Humans
* Male
* Memory, Short-Term
* Young Adult


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726243
-
}}
==CDC20==


===Keywords===
{{medline-entry
T-cell; T-cell homeostasis; aging; chromatin accessibility; epigenetics; ribosomal proteins
|title=Premature aging syndrome showing random chromosome number instabilities with [[CDC20]] mutation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33094908


==Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK  CD8  T Cells as Conserved Hallmark of Inflammaging.==
===Abstract===
Systematic understanding of immune aging on a whole-body scale is currently lacking. We characterized age-associated alterations in immune cells across multiple mouse organs using single-cell RNA and antigen receptor sequencing and flow cytometry-based validation. We defined organ-specific and common immune alterations and identified a subpopulation of age-associated granzyme K (GZMK)-expressing CD8  T (Taa) cells that are distinct from T effector memory (Tem) cells. Taa cells were highly clonal, had specific epigenetic and transcriptional signatures, developed in response to an aged host environment, and expressed markers of exhaustion and tissue homing. Activated Taa cells were the primary source of GZMK, which enhanced inflammatory functions of non-immune cells. In humans, proportions of the circulating GZMK CD8  T cell population that shares transcriptional and epigenetic signatures with mouse Taa cells increased during healthy aging. These results identify GZMK  Taa cells as a potential target to address age-associated dysfunctions of the immune system.


===MeSH Terms===
|keywords=* Cdc20 proteins
-
* M phase cell cycle checkpoints
* aging
* chromosomal instability
* chromosome segregation
* genomic instability
* premature
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681047
}}
==CDC25A==


===Keywords===
{{medline-entry
Aging; CD8 T cells; CITE-seq; granzyme K; immune system; inflammaging; single-cell ATAC-sequencing; single-cell BCR-sequencing; single-cell RNA-sequencing; single-cell TCR-sequencing
|title=Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33050379


==Effects of Blood Pressure on Cognitive Performance in Aging: A Systematic Review.==
===Abstract===
Cognitive functions play a crucial role in daily functioning. Unfortunately, some cognitive abilities decline in the process of healthy aging. An increasing body of evidence has highlighted the role of lifestyle habits and cardiovascular diseases, such as high blood pressure, in increasing the risk of cognitive decline. Surprisingly, although hypertension is a modifiable risk factor for cerebrovascular damage, the role of hypertension on cognitive impairment development is not still clear. Several key questions remain unresolved, and there are many inconsistent results in studies considering this topic. This review is aimed to systematically analyze the results found by the studies that investigated whether high blood pressure, in both hypertensive and healthy people, is related to cognitive performance. Furthermore, it points to evaluate the role of age in this relationship. [i]Method:[/i] The review process was conducted according to the PRISMA statement. Restrictions were made, selecting the studies in English and published in peer-review journals, including at least one cognitive measure and blood pressure measurement. Studies that included participants with medical conditions, dementia, psychiatric disorders, strokes, and brain injury were excluded. Cross-sectional and longitudinal studies were analyzed separately. Finally, blood pressure measured at young life (18-39 years), midlife (age 40-64 years), elderly (65-74 years), and old age (≥75 years) were considered. [i]Results:[/i] The review allows 68 studies to be selected, which include 154,935 participants. The results provided evidence of an adverse effect of exposure to high blood pressure on cognitive performance. High blood pressure in midlife was linked with poorer cognitive functioning; this evidence was found in cross-sectional and longitudinal studies. However, this association declines with increasing age and tends to become inconsistent. In older people, the relationship between blood pressure and cognitive performance is non-linear, highlighting a beneficial effect of high blood pressure on cognition. [i]Conclusions:[/i] Despite some limitations, this review showed that cardiovascular and neuro-cognitive systems do not operate in isolation, but they are related. Blood pressure can be considered an early biomarker of cognitive impairment, and the necessity of early blood pressure measurement and control was underlined.


===MeSH Terms===
|keywords=* Babam2
-
* DNA damage
* cell cycle
* embryonic stem cells
* pluripotency
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600899
}}
==CDC42==


===Keywords===
{{medline-entry
aging; blood pressure; cognitive functions; cognitive impairment; hypertension; review
|title=Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31487690


==Psychosocial Factors Associated with Cognitive Function Among Middle-Aged and Older Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos and its Sociocultural Ancillary Study.==
|mesh-terms=* Adaptor Proteins, Signal Transducing
===Abstract===
* Adult
Evidence suggests that psychosocial factors are associated with cognitive health in older adults; however, associations of psychosocial factors with cognition remain largely unexamined in middle-aged and older Hispanics/Latinos. To examine the cross-sectional associations of psychosocial factors with cognitive function among middle-aged and older Hispanics/Latinos living in the US. Baseline (2008-2011) data from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study (n = 2,818; ages 45-74) were used to examine the associations of each psychosocial factor with global cognition (GC), verbal learning, verbal memory, verbal fluency, and processing speed independent of age, sex, education, Hispanic/Latino background, income, language, and depressive symptoms. Psychosocial variables included: intrapersonal factors (ethnic identity, optimism, and purpose in life), interpersonal factors (family cohesion, familism, social network embeddedness, and social support), and social stressors (perceived ethnic discrimination, loneliness, and subjective social status). In fully-adjusted models, purpose in life and social support were each positively associated with all five cognitive variables. Loneliness was negatively associated with GC, verbal learning, memory, and processing speed. Ethnic identity was positively and familism negatively associated with GC, verbal fluency, and processing speed. Family cohesion was positively associated with verbal learning. These findings extend previous evidence from older, largely non-Hispanic White cohorts to show that higher purpose in life and social support are also strongly associated with cognitive health among middle-aged and older Hispanics/Latinos. We also highlight that intrapersonal factors, interpersonal factors, and social stressors have differential relationships with individual cognitive tests.
* Aging
* Animals
* Cell Cycle Proteins
* Cell Size
* Endothelial Cells
* Female
* Humans
* Male
* Mice, Inbred C57BL
* Middle Aged
* Neovascularization, Physiologic
* Primary Cell Culture
* Transcription Factors
* cdc42 GTP-Binding Protein
|keywords=* aging
* angiogenesis
* cell proliferation
* cell size
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756888
}}
==CDH1==


===MeSH Terms===
{{medline-entry
-
|title=Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32010971


===Keywords===
Cognitive aging; Hispanics; Latinos; cognitive function; psychosocial factors


==The Geriatric Feelings of Burdensomeness Scale (GFBS).==
|keywords=* Cdc6
===Abstract===
* cytoplasmic Cdc6
: The present article describes the development and psychometric evaluation of the Geriatric Feelings of Burdensomeness Scale using two samples of older adults collected through Amazon Mechanical Turk. The scale is a 25-item measure of general subjective feeling of being a burden on or problem for others. The goal of the measure is to capture a broad conceptualization of burdensomeness that is relevant to a variety of important psychological variables.  : Two studies are described, including item development and selection, and the examination of reliability and validity evidence in a sample of 192 older adults. : The estimates of reliability (coefficient alpha and average interitem correlations) were strong. Preliminary examination of convergent validity evidence found significant moderate correlations between the Geriatric Feelings of Burdensomeness Scale and measures of conceptually related constructs (hopelessness, suicidality, perceived burdensomeness, thwarted belongingness). Small, non-significant correlations were found between three indices of religiosity, providing preliminary discriminant validity evidence.  : Our results provide initial psychometric support for a more general and inclusive assessment tool for measuring older adults' feelings of burdensomeness.  : With further research on clinical significance of feelings of burdensomeness and predictive validity, this measure may be used to identify concerns and beliefs about burdensomeness among distressed older adults.
* pancreatic cancer
* senescence
* subcellular localisation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496346
}}
==CDK1==


===MeSH Terms===
{{medline-entry
-
|title=MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31848878


===Keywords===
|mesh-terms=* CDC2-CDC28 Kinases
Older adults; aging; assessment; burden; measurement; mental health
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* Cyclin B
* Gene Expression Regulation, Developmental
* Humans
* Mesenchymal Stem Cells
* MicroRNAs
* Transcriptome
* Tumor Suppressor Protein p53
* Umbilical Cord
|keywords=* Cell proliferation
* Cell senescence
* Cellular ageing
* Human Mesenchymal stem / stromal cells
* miRNA-mRNA integration
|full-text-url=https://sci-hub.do/10.1007/s12015-019-09924-0
}}
==CDK2==


==Can Serum Nitrosoproteome Predict Longevity of Aged Women?==
{{medline-entry
===Abstract===
|title=p57  is a master regulator of human adipose derived stem cell quiescence and senescence.
Aging is characterized by increase in reactive oxygen (ROS) and nitrogen (RNS) species, key factors of cardiac failure and disuse-induced muscle atrophy. This study focused on serum nitroproteome as a trait of longevity by adopting two complementary gel-based techniques: two-dimensional differential in gel electrophoresis (2-D DIGE) and Nitro-DIGE coupled with mass spectrometry of albumin-depleted serum of aged (A, [i]n[/i] = 15) and centenarian (C, [i]n[/i] = 15) versus young females (Y, [i]n[/i] = 15). Results indicate spots differently expressed in A and C compared to Y and spots changed in A vs. C. Nitro-DIGE revealed nitrosated protein spots in A and C compared to Y and spots changed in A vs. C only ([i]p[/i]-value < 0.01). Nitro-proteoforms of alpha-1-antitripsin (SERPINA1), alpha-1-antichimotripsin (SERPINA3), ceruloplasmin (CP), 13 proteoforms of haptoglobin (HP), and inactive glycosyltransferase 25 family member 3 (CERCAM) increased in A vs. Y and C. Conversely, nitrosation levels decreased in C vs. Y and A, for immunoglobulin light chain 1 (IGLC1), serotransferrin (TF), transthyretin (TTR), and vitamin D-binding protein (VDBP). Immunoblottings of alcohol dehydrogenase 5/S-nitrosoglutathione reductase (ADH5/GSNOR) and thioredoxin reductase 1 (TRXR1) indicated lower levels of ADH5 in A vs. Y and C, whereas TRXR1 decreased in A and C in comparison to Y. In conclusion, the study identified putative markers in C of healthy aging and high levels of ADH5/GSNOR that can sustain the denitrosylase activity, promoting longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32224418


===MeSH Terms===
-


===Keywords===
|keywords=* Human adipose derived stem cells
aging; cardiovascular disease; muscle atrophy; nitrosative stress; proteomics
* Quiescence
* Senescence
* p57(Kip2)
|full-text-url=https://sci-hub.do/10.1016/j.scr.2020.101759
}}
==CDK4==


==[The age-related positivity effect: forgetting the negative and/or remembering the positive? An inter-task study].==
{{medline-entry
===Abstract===
|title=Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.
A growing number of studies have shown that, compared to young adults, older adults better remember positive information than negative information. However, it is not clear whether this age-related positivity effect relies on an increase in positive information memory and/or on a decrease in negative information memory. Thus, we aimed to study the specific mechanisms underlying the age-related positivity effect in different memory tasks. To do so, we used an emotional word memory paradigm including immediate free recall, recognition and delayed free recall tasks. Forty-five young adults (m = 20.0 years) and 45 older adults (m = 69.2 years) native French speakers participated. Thirty-six low French words, including 12 negative (e.g. égout), 12 positive (e.g. lagune) and 12 neutral (e.g. notion) words were selected from an emotional lexical database (Gobin et al. 2017). For the recognition task, 36 new words were selected. The results showed that the age-related positivity effect specifically depended on a decrease in negativity preference (i.e. the comparison between negative and neutral words) in older adults, in comparison with young adults, both in immediate and delayed free recall tasks. Indeed, in these tasks, young adults recalled more negative than neutral words whereas there was no difference in older adults. In recognition task, no age-related positivity effect has been observed. Moreover, the results showed that, in immediate recall, the higher the older adults memory abilities, the lower their negativity preference. This correlation was not significant in delayed recall. These results suggest that, when compared with young adults, older adults disengage from negative words processing through costly cognitive processes. A small magnitude of negativity preference would indicate good maintenance of memory abilities. Results are discussed in the framework of the socioemotional selectivity theory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32971832


===MeSH Terms===
-


===Keywords===
|keywords=* adipogenesis
aging; emotion; memory; positivity effect
* inflammation
* insulin sensitivity
* obesity
* oxidative activity
* senescence
* type 2 diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563355
}}
{{medline-entry
|title=Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32915425


==Association between brain volumes and patterns of physical activity in community-dwelling older adults.==
===Abstract===
Larger brain volumes are often associated with more free-living physical activity (PA) in cognitively normal older adults. Yet, whether greater brain volumes are associated with more favorable (less fragmented) PA patterns, and whether this association is stronger than with total PA, remains unknown. Brain magnetic resonance imaging and wrist-worn accelerometer data were collected in 301 participants (mean age=77[SD=7] years, 59% women) enrolled in the Baltimore Longitudinal Study of Aging. Linear regression models were fit to examine whether brain volumes (cc) were cross-sectionally associated with: 1) total daily PA minutes; and 2) activity fragmentation (mean number of PA bouts / total PA minutes x 100). Sensitivity analyses were conducted by adjusting for counterpart PA variables (e.g., fragmentation covariate included in the PA minutes model). Greater white matter volumes in the parietal and temporal lobes were associated with higher daily PA minutes (2.6(SE=1.0) and 3.8(0.9)min/day, respectively; p<0.009 for both) after adjusting for demographics, behavioral factors, medical conditions, gait speed, apolipoprotein E e4 status, and intracranial volume. Greater temporal white matter volume was associated with lower fragmentation (-0.16(0.05)%, p=0.003). In sensitivity analyses, observed associations between brain volumes and daily PA minutes remained significant while associations with fragmentation no longer remained significant. Our results suggest white matter brain structure in cognitively normal older adults is associated with the total amount of PA and, to a lesser extent, the PA accumulation patterns. More work is needed to elucidate the longitudinal relationship between brain structure and function and PA patterns with aging.


===MeSH Terms===
|keywords=* Chinese medicine
-
* Guilu Erxian Glue
* bone marrow suppression
* hematopoietic stem cell senescence
* p16INK4a
|full-text-url=https://sci-hub.do/10.1007/s11655-020-3098-3
}}
==CDK5==


===Keywords===
{{medline-entry
Aging; brain structure; fragmentation; total activity; white matter
|title=Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636448


==Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis.==
|mesh-terms=* Aging
===Abstract===
* Animals
Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age-dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age-related anxiety-like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.
* Cell Cycle
* Cell Death
* Cellular Senescence
* Cyclin-Dependent Kinase 5
* Excitatory Postsynaptic Potentials
* Gene Expression
* Glycolysis
* Hexokinase
* Hyperinsulinism
* Inhibitory Postsynaptic Potentials
* Insulin
* Insulin Resistance
* Liraglutide
* Male
* Maze Learning
* Metformin
* Mice
* Neurons
* Phosphotransferases
* Primary Cell Culture
* Protein-Serine-Threonine Kinases
* Ubiquitination
* beta Catenin


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1038/s41593-019-0505-1
-
}}
==CDK6==


===Keywords===
{{medline-entry
adult hippocampal neurogenesis; lamin B1; mood regulation; stem cell aging
|title=Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970940


==Retention Forces of Prosthetic Clasps over a Simulated Wearing Period of Six Years In-Vitro: Direct Metal Laser Melting Versus Dental Casting.==
===Abstract===
This study determinates the persistence of retention force in Akers-clasps for removable partial dentures made from Co-Cr alloy. Therefore, standardized computer-aided designed (CAD) clasp #1 specimens were made by direct metal laser melting (DMLM, n = 10) and by lost-wax dental casting (DC) of computer-aided manufactured (CAM) replicas (n = 10, DC) from two comparable Co-Cr alloys. The retention force was tested after manufacturing for 9000 cycles of setting and removal from a molar tooth crown analog made from zirconia; simulating in-vitro a duration of six years in service. The first and last 360 cycles (T0 and T1, 3 months each) of all specimens were selected for comparison of retention forces between the materials. A constant decrease of 6% from the initial retention force (T0 = 4.86 N, SD = 0.077; T1 = 4.57 N, SD = 0.037) was detected at the DC specimens, and an increase of 4% in DMLM specimens (T0 = 5.69 N, SD = 0.078; T1 = 5.92 N, SD = 0.077); all differences were statistically significant ([i]p[/i] < 0.0001). Even if these deviations are not of clinical relevance, further studies and applications should investigate the fatigue behavior of laser melted Co-Cr-alloys for dental application.


===MeSH Terms===
|keywords=* cyclin-dependent kinase 6 (CDK6)
-
* high-fat diet (HFD)
* miR-34a
* palmitate acid (PA)
* senescence
|full-text-url=https://sci-hub.do/10.1002/mnfr.202000383
}}
{{medline-entry
|title=Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32454116


===Keywords===
additive manufacturing; ageing; dental prosthesis; longevity; non-precious alloy


==Refined Multiscale Fuzzy Entropy to Analyse Post-Exercise Cardiovascular Response in Older Adults With Orthostatic Intolerance.==
|keywords=* D-galactose
===Abstract===
* Hydroxysafflor yellow A
Orthostatic intolerance syndrome occurs when the autonomic nervous system is incapacitated and fails to respond to the demands associated with the upright position. Assessing this syndrome among the elderly population is important in order to prevent falls. However, this problem is still challenging. The goal of this work was to determine the relationship between orthostatic intolerance (OI) and the cardiovascular response to exercise from the analysis of heart rate and blood pressure. More specifically, the behavior of these cardiovascular variables was evaluated in terms of refined composite multiscale fuzzy entropy (RCMFE), measured at different scales. The dataset was composed by 65 older subjects, 44.6% ([i]n[/i] = 29) were OI symptomatic and 55.4% ([i]n[/i] = 36) were not. Insignificant differences were found in age and gender between symptomatic and asymptomatic OI participants. When heart rate was evaluated, higher differences between groups were observed during the recovery period immediately after exercise. With respect to the blood pressure and other hemodynamic parameters, most significant results were obtained in the post-exercise stage. In any case, the symptomatic OI group exhibited higher irregularity in the measured parameters, as higher RCMFE levels in all time scales were obtained. This information could be very helpful for a better understanding of cardiovascular instability, as well as to recognize risk factors for falls and impairment of functional status.
* Oxidative stress
* Replicative senescence
* p16
|full-text-url=https://sci-hub.do/10.1016/j.ejphar.2020.173214
}}
{{medline-entry
|title=Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31823286


===MeSH Terms===
-


===Keywords===
|keywords=* Breast cancer
aging; blood pressure; exercise; hear rate; orthostatic intolerance; refined composite multiscale fuzzy entropy
* CDK4
* Cancer stem cells
* Palbociclib
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s12282-019-01035-5
}}
{{medline-entry
|title=Compromising the constitutive p16  expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692039


==Ultrasonography Shows Age-related Changes and Related Factors in the Tongue and Suprahyoid Muscles.==
===Abstract===
To investigate age and other factors related to the deterioration of the muscles used for swallowing, including the tongue and suprahyoid muscles. Cross-sectional study. This study included 146 participants: 47 younger adults (23 men and 24 women; age range 23-44 years) recruited from a dental hospital and 99 community-dwelling older adults (37 men and 62 women, age range 65-86 years). Age (<65 years or ≥65 years), body mass index (BMI), skeletal muscle mass index (SMI), and tooth loss (Eichner classification) were measured. The cross-sectional areas (CSAs) of the tongue, geniohyoid muscle, and anterior belly of the digastric muscle were measured using an ultrasonic diagnostic apparatus. The correlation between each muscle's CSA and strength was examined. Multiple regression analyses were performed separately for each sex using each muscle CSA as the dependent variable and age, BMI, SMI, and the Eichner classification as explanatory variables. Older men had a significant positive correlation between tongue pressure and CSA (r = 0.35, P = .031). Jaw opening force was positively correlated with geniohyoid muscle CSA (r = 0.41, P = .001) in older women. In the multiple regression analysis, age, BMI, and SMI were significantly associated with tongue CSA in men. Age was significantly and inversely associated with suprahyoid muscle CSA in both men and women. No explanatory variables were significantly associated with geniohyoid muscle CSA except age. The tongue increased in volume, and the suprahyoid muscles underwent atrophy with age. The study results suggest that interventions to prevent dysphagia associated with aging should be tailored toward specific muscles. Direct muscle training is required for the suprahyoid muscles, whereas the maintenance of tongue muscle mass and function, as well as training for the tongue, requires attention to ensure optimal nutritional status and whole-body skeletal muscle mass.


===MeSH Terms===
|keywords=* 17AAG
-
* Hsp90
* cancer
* p16INK4a
* senescence
* tumor suppressor
|full-text-url=https://sci-hub.do/10.1002/jcb.29493
}}
==CDKN1A==


===Keywords===
{{medline-entry
Aging; body mass index; cross-sectional area; digastric muscle; geniohyoid muscle; tongue
|title=Involvement of [[CDKN1A]] (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253738


==Development of a Geropathology Grading Platform for nonhuman primates.==
===Abstract===
A geropathology grading platform (GGP) for assessing age-related lesions has been established and validated for in inbred strain of mice. Because nonhuman primates (NHPs) share significant similarities in aging and spontaneous chronic diseases with humans, they provide excellent translational value for correlating histopathology with biological and pathological events associated with increasing age. Descriptive age-associated pathology has been described for rhesus macaques and marmosets, but a grading platform similar to the mouse GGP does not exist. The value of these NHP models is enhanced by considerable historical data from clinical, bio-behavioral, and social domains that align with health span in these animals. Successful adaptation of the mouse GGP for NHPs will include 1) expanding the range of organs examined; 2) standardizing necropsy collection, tissue trimming, and descriptive lesion terminology; 3) expanding beyond rhesus macaques and marmosets to include other commonly used NHPs in research; and 4) creating a national resource for age-related pathology to complement the extensive in-life datasets. Adaptation of the GGP to include translational models other than mice will be crucial to advance geropathology designed to enhance aging research.


===MeSH Terms===
|keywords=* Cdkn1a
-
* Heat stress
* Irradiation
* Preimplantation
* Senescence
* p21
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193008
}}
==CDKN2A==


===Keywords===
{{medline-entry
Aging; age-related diseases; geropathology; geroscience; marmosets; mice; nonhuman primates; rhesus macaques
|title=Association between Nrf2 and [[CDKN2A]] expression in patients with end-stage renal disease: a pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32661200


==Age-Related Frailty: A Clinical Model for Geroscience?==
===Abstract===
In their everyday practice, geriatricians are confronted with the fact that older age and multimorbidity are associated to frailty. Indeed, if we take the example of a very old person with no diseases that progressively becomes frail with no other explanation, there is a natural temptation to link frailty to aging. On the other hand, when an old person with a medical history of diabetes, arthritis and congestive heart failure becomes frail there appears an obvious relationship between frailty and comorbidity. The unsolved question is: Considering that frailty is multifactorial and in the majority of cases comorbidity and aging are acting synergistically, can we disentangle the main contributor to the origin of frailty: disease or aging? We believe that it is important to be able to differentiate age-related frailty from frailty related to comorbidity. In fact, with the emergence of geroscience, the physiopathology, diagnosis, prognosis and treatment will probably have to be different in the future.


===MeSH Terms===
|keywords=* CDKN2A
-
* Nrf2
* aging
* end-stage renal disease
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485736
}}
==CDKN2B==


===Keywords===
{{medline-entry
Frailty causes; age-related frailty; aging; frailty related to diseases; geroscience
|title=Molecular Genetics and Functional Analysis Implicate [i][[CDKN2B]]AS1-[[CDKN2B]][/i] Involvement in POAG Pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32825664


==Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice.==
===Abstract===
Synaptic aging has been associated with neuronal circuit dysfunction and cognitive decline. Reduced mitochondrial function may be an early event that compromises synaptic integrity and neurotransmission in vulnerable brain regions during physiological and pathological aging. Thus, we aimed to measure mitochondrial function in synapses from three brain regions at two different ages in the 3xTg-AD mouse model and in wild mice. We found that aging is the main factor associated with the decline in synaptic mitochondrial function, particularly in synapses isolated from the cerebellum. Accumulation of toxic compounds, such as tau and Aβ, that occurred in the 3xTg-AD mouse model seemed to participate in the worsening of this decline in the hippocampus. The changes in synaptic bioenergetics were also associated with increased activation of the mitochondrial fission protein Drp1. These results suggest the presence of altered mechanisms of synaptic mitochondrial dynamics and their quality control during aging and in the 3xTg-AD mouse model; they also point to bioenergetic restoration as a useful therapeutic strategy to preserve synaptic function during aging and at the early stages of Alzheimer's disease (AD).


===MeSH Terms===
|keywords=* African Americans
-
* CDKN2B-AS1
* Primary open-angle glaucoma (POAG)
* senescence
* trabecular meshwork cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564117
}}
==CFI==


===Keywords===
{{medline-entry
amyloid-β protein; brain aging; mitochondrial dynamics; synaptic mitochondria; synaptosomes; tau
|title=Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781590


==Serine and Metabolism Regulation: A Novel Mechanism in Antitumor Immunity and Senescence.==
|mesh-terms=* Adult
===Abstract===
* Aged
As one of the nonessential amino acids (NEAAs), serine is involved in the anabolism of multiple macromolecular substances by participating in one-carbon unit metabolism. Thus, rapidly proliferating cells such as tumor cells and activated immune cells are highly dependent on serine. Serine supports the proliferation of various immune cells through multiple pathways to enhance the antitumor immune response. Moreover, serine influences aging specificity in an epigenetic and metabolic manner. In this review, we focus on recent advances in the relationship between serine metabolism, antitumor immunity, and senescence. The metabolic regulation of serine seems to be a key point of intervention in antitumor immunity and aging-related disease, providing an opportunity for several novel therapeutics.
* Aged, 80 and over
* Aging
* Cross-Sectional Studies
* Female
* Happiness
* Health Status
* Humans
* Male
* Personal Satisfaction
* Quality of Life
|keywords=* happiness
* older adults
* path analysis
* psychosocial resources
* subjective well-being
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459462
}}
{{medline-entry
|title=Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546985


===MeSH Terms===
|mesh-terms=* Aged
-
* Aging
* Cross-Sectional Studies
* Female
* Geriatric Assessment
* Health Status Disparities
* Humans
* Iran
* Male
* Mental Health
* Psychometrics
* Reproducibility of Results
* Surveys and Questionnaires
|keywords=* aging
* factor analysis
* flourishing
* reliability
* validity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244746
}}
{{medline-entry
|title=The decision about retirement: A scale to describe representations and practices of medical doctors and nurses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32258559


===Keywords===
Serine; antitumor immunity and senescence; metabolism


==Receptor tyrosine kinases-instructed release of its inhibitor from hydrogel to delay ovarian aging.==
|keywords=* Aging
===Abstract===
* Job satisfaction
Premature ovarian failure (POF) is the most frequently occurred disease in ovary. Direct inhibition of mammalian target of rapamycin (mTOR) activity can treat woman POF but brings adverse effects to women. Herein, by rational design of a hydrogelator Nap-Phe-Phe-Asp-Arg-Leu-Tyr-OH (Y) and co-assembling Y with an inhibitor of receptor tyrosine kinase (RTK, an upstream kinase of mTOR), Ala-Glu-Ala-Ala-Leu-Tyr-Lys-Asn-Leu-Leu-His-Ser-OH (Inh), to form hydrogel Gel Y + Inh, we develop a "smart" strategy of RTK-responsive disassembly of the hydrogel to release Inh. Release of Inh moderately inhibits the activity of mTOR and therefore delays ovarian aging. Oocyte and zygote experiments show that Gel Y + Inh improves both meiotic maturation of the oocytes and early embryonic development of the zygotes. In vivo animal experiments indicate that Gel Y + Inh effectively delays ovarian aging in aged mice by down regulation of mTOR activity, stimulation of ovaries to secrete estrogen and progesterone, and development of more antral follicles for reproduction. We expect that our new hydrogel Gel Y + Inh could be applied to treat woman POF, as well as delay ovarian aging, in clinic in the near future.
* Retirement
* Scale
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806742
}}
{{medline-entry
|title=Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31697103


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Aging
* Emotions
* Family Relations
* Female
* Health Status
* Humans
* Interpersonal Relations
* Longitudinal Studies
* Male
* Middle Aged
* Sexual Partners
* United States


===Keywords===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012715
Hydrogel; Ovarian aging; Receptor tyrosine kinases; Responsive release
}}
{{medline-entry
|title=Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524131


==Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia.==
===Abstract===
Sarcopenia that occurs with advancing age is characterized by a gradual loss of muscle protein component due to the activation of catabolic pathways, increased level of inflammation, and mitochondrial dysfunction. Experimental evidence demonstrates that several physio-pathological processes involved in the onset of sarcopenia may be counteracted by the intake of specific amino acids or antioxidant molecules, suggesting that diet may represent an effective strategy for improving the anabolic response of muscle during aging. The non-essential amino acid taurine is highly expressed in several mammalian tissues, including skeletal muscle where it is involved in the ion channel regulation, in the modulation of intracellular calcium concentration, and where it plays an important role as an antioxidant and anti-inflammatory factor. Here, with the purpose to reproduce the chronic low-grade inflammation characteristics of senescent muscle in an in vitro system, we exploited the role of Tumor Necrosis Factor α (TNF) and we analyzed the effect of taurine in the modulation of different signaling pathways known to be dysregulated in sarcopenia. We demonstrated that the administration of high levels of taurine in myogenic L6 cells stimulates the differentiation process by downregulating the expression of molecules involved in inflammatory pathways and modulating processes such as autophagy and apoptosis. Although further studies are currently ongoing in our laboratory to better elucidate the molecular mechanisms responsible for the positive effect of taurine on myogenic differentiation, this study suggests that taurine supplementation may represent a strategy to delay the loss of mass and functionality characteristic of senescent muscles.


===MeSH Terms===
|keywords=* aging
-
* life span
* self-esteem
* structural equation model
* validity
|full-text-url=https://sci-hub.do/10.1017/S1041610219001170
}}
==CFTR==


===Keywords===
{{medline-entry
aging; antioxidants; autophagy; inflammation; nutrition; skeletal muscle
|title=Exercise Physiology Across the Lifespan in Cystic Fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31780953


==Late Passage Cultivation Induces Aged Astrocyte Phenotypes in Rat Primary Cultured Cells.==
===Abstract===
Astrocytes play various important roles such as maintaining brain homeostasis, supporting neurons, and secreting inflammatory mediators to protect the brain cells. In aged subjects, astrocytes show diversely changed phenotypes and dysfunctions. But, the study of aged astrocytes or astrocytes from aged subjects is not yet sufficient to provide a comprehensive understanding of their important processes in the regulation of brain function. In this study, we induced an [i]in vitro[/i] aged astrocyte model through late passage cultivation of rat primary cultured astrocytes. Astrocytes were cultured until passage 7 (P7) as late passage astrocytes and compared with passage 1 (P1) astrocytes as early passage astrocytes to confirm the differences in phenotypes and the effects of serial passage. In this study, we confirmed the morphological, molecular, and functional changes of late passage astrocytes showing aging phenotypes through SA-β-gal staining and measurement of nuclear size. We also observed a reduced expression of inflammatory mediators including IL-1β, IL-6, TNFα, iNOS, and COX2, as well as dysregulation of wound-healing, phagocytosis, and mitochondrial functions such as mitochondrial membrane potential and mitochondrial oxygen consumption rate. Cultureconditioned media obtained from P1 astrocytes promoted neurite outgrowth in immature primary cultures of rat cortices, which is significantly reduced when we treated the immature neurons with the culture media obtained from P7 astrocytes. These results suggest that late passage astrocytes show senescent astrocyte phenotypes with functional defects, which makes it a suitable model for the study of the role of astrocyte senescence on the modulation of normal and pathological brain aging.


===MeSH Terms===
|keywords=* aging
-
* cystic fibrosis
* exercise capacity
* exercise prescription
* pediatric
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856653
}}
{{medline-entry
|title=Reduced expression of the Ion channel [[CFTR]] contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31477092


===Keywords===
|mesh-terms=* Aging
Astrocytes; Cellular senescence; Late passage cultivation; Neuro-inflammatory response; Phagocytosis; Wound healing
* Animals
* Cystic Fibrosis Transmembrane Conductance Regulator
* Gene Expression
* Inhalation Exposure
* Mice
* Mice, Knockout
* Pulmonary Emphysema
* Tobacco Smoke Pollution
|keywords=* Aging
* CFTR
* Emphysema
* Smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720379
}}
==CGA==


==Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.==
{{medline-entry
===Abstract===
|title=Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial.
Endothelial dysfunction is one of the main age-related arterial phenotypes responsible for cardiovascular disease (CVD) in older adults. This endothelial dysfunction results from decreased bioavailability of nitric oxide (NO) arising downstream of endothelial oxidative stress. In this study, we investigated the protective effect of anthocyanins and the underlying mechanism in rat thoracic aorta and human vascular endothelial cells in aging models. In vitro, cyanidin-3-rutinoside (C-3-R) and cyanidin-3-glucoside (C-3-G) inhibited the d-galactose (d-gal)-induced senescence in human endothelial cells, as indicated by reduced senescence-associated-β-galactosidase activity, p21, and p16  . Anthocyanins blocked d-gal-induced reactive oxygen species (ROS) formation and NADPH oxidase activity. Anthocyanins reversed d-gal-mediated inhibition of endothelial nitric oxide synthase (eNOS) serine phosphorylation and SIRT1 expression, recovering NO level in endothelial cells. Also, SIRT1-mediated eNOS deacetylation was shown to be involved in anthocyanin-enhanced eNOS activity. In vivo, anthocyanin-rich mulberry extract was administered to aging rats for 8 weeks. In vivo, mulberry extract alleviated endothelial senescence and oxidative stress in the aorta of aging rats. Consistently, mulberry extract also raised serum NO levels, increased phosphorylation of eNOS, increased SIRT1 expression, and reduced nitrotyrosine in aortas. The eNOS acetylation was higher in the aging group and was restored by mulberry extract treatment. Similarly, SIRT1 level associated with eNOS decreased in the aging group and was restored in aging plus mulberry group. These findings indicate that anthocyanins protect against endothelial senescence through enhanced NO bioavailability by regulating ROS formation and reducing eNOS uncoupling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160954


===MeSH Terms===
-


===Keywords===
|keywords=* Comprehensive geriatric assessment
NO; SIRT1; anthocyanins; eNOS deacetylation; senescence
* Geriatrics
* Preoperative chemoradiotherapy
* Rectal cancer
|full-text-url=https://sci-hub.do/10.1016/j.jgo.2020.10.016
}}
{{medline-entry
|title=The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630570


==Eating Problems in Advanced Dementia: Navigating Difficult Conversations.==
===Abstract===
The majority of older adults with advanced dementia (AD) develop difficulties with eating and swallowing, often prompting concerns about nutrition and quality of life. Employing a palliative approach requires providers to attain skills in addressing symptoms and communicating with family caregivers about the trajectory of AD and associated dysphagia, as well as to elicit goals of care. Research suggests internal medicine (IM) residents often perceive minimal education during training addressing skills needed to care for patients with AD. We developed and piloted a small-group interactive seminar utilizing a trigger video depicting a family meeting addressing eating problems in a patient with AD. Case-based learning, small-group discussion, and learner reflection were employed. We assessed the impact on 82 of the 106 IM, medicine-pediatrics, and neurology residents who participated in the seminar. Participant evaluation indicated residents showed high satisfaction and perceived the educational content of the seminar to be robust and clinically relevant. We found statistically significant ([i]p[/i] < .001) improvements in self-reported confidence in dementia-specific skills postseminar. Effect size was large to very large (Cohen's [i]d[/i] = 1.3-1.7). An interactive, case-based seminar utilizing a video depicting a realistic family meeting improved residents' self-efficacy in skills needed to address nutritional issues, engage in goals-of-care discussions, and reflect on concerns among caregivers of patients with AD. The seminar teaches important geriatric and palliative concepts meant to improve residents' ability to care for older adults with AD in their future careers.


===MeSH Terms===
|keywords=* chlorogenic acid
-
* heme oxygenase-1
* nuclear factor erythroid 2-related factor 2
* vascular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350250
}}
{{medline-entry
|title=Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566923


===Keywords===
Advanced Dementia; Case-Based Learning; Dysphagia; Geriatrics; Geriatrics Education; Hospice & Palliative Medicine; Palliative Care Education; Resident Education


==Long-term intake of the illegal diet pill DNP reduces lifespan in a captive bird model.==
|keywords=* Comprehensive geriatric assessment
===Abstract===
* Geriatrics
2,4-Dinitrophenol (DNP), a molecule uncoupling mitochondrial oxidative phosphorylation from oxygen consumption, is illegally used by humans as a diet pill, but is nonetheless investigated as a potential human medicine against 'metabesity'. Due to its proven acute toxicity and the scarceness of long-term studies on DNP administration in vertebrates, we determined the impact of a long-term DNP treatment (~4 mg.kg .day , i.e. within the range taken illegally by humans) on body mass, metabolism, ageing and lifespan in a captive bird model, the zebra finch. The chronic absorption of DNP over life (>4 years) led to a mild increase in energy expenditure (ca. +11% compared to control group), without significantly altering the normal slight increase in body mass with age. DNP did not significantly influence the alteration of physical performance, the rise in oxidative damage, or the progressive shortening of telomeres with age. However, DNP-treated individuals had a significantly shorter lifespan (ca. -21% in median lifespan compared to control group), thereby raising potential concerns about DNP use as a diet pill or medicine.
* Japanese diagnosis procedure combination database
* Length of stay
* Mortality
* Stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298723
}}
{{medline-entry
|title=Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417101


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
2,4-Dinitrophenol; Longevity; Mitochondrial uncoupling; Oxidative stress; Survival; Toxicity
* comprehensive geriatric assessment
* delirium
* functional status
* outcomes
* surgery
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.03.023
}}
{{medline-entry
|title=A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-[[CGA]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32296673


==Nutrients and Pathways that Regulate Health Span and Life Span.==
===Abstract===
Both life span and health span are influenced by genetic, environmental and lifestyle factors. With the genetic influence on human life span estimated to be about 20-25%, epigenetic changes play an important role in modulating individual health status and aging. Thus, a main part of life expectance and healthy aging is determined by dietary habits and nutritional factors. Excessive or restricted food consumption have direct effects on health status. Moreover, some dietary interventions including a reduced intake of dietary calories without malnutrition, or a restriction of specific dietary component may promote health benefits and decrease the incidence of aging-related comorbidities, thus representing intriguing potential approaches to improve healthy aging. However, the relationship between nutrition, health and aging is still not fully understood as well as the mechanisms by which nutrients and nutritional status may affect health span and longevity in model organisms. The broad effect of different nutritional conditions on health span and longevity occurs through multiple mechanisms that involve evolutionary conserved nutrient-sensing pathways in tissues and organs. These pathways interacting each other include the evolutionary conserved key regulators mammalian target of rapamycin, AMP-activated protein kinase, insulin/insulin-like growth factor 1 pathway and sirtuins. In this review we provide a summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span.


===MeSH Terms===
|keywords=* aging
-
* comprehensive geriatric assessment (CGA)
* electronic assessment tools
* frailty
* frailty index
* healthcare
* older adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137764
}}
{{medline-entry
|title=Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942488


===Keywords===
aging; health span; life span; nutrient-sensing pathways; nutrients


==The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a "bright" new strategy for the prevention of age-related skin pathologies?==
|keywords=* clinical frailty scale
===Abstract===
* frail older adults
The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to find treatments that aim either to cleanse the skin tissues of senescent cells or to neutralize their effects (referred to as senolytics and senomorphics respectively) and thus prevent the consequences, particularly on the skin's appearance in advanced age. Through this review, we have tried to gather data on the role of senescent cells in the skin, in treatments aimed at removing them, and we are asking a reasonable question as to whether anti-senescence treatments may contribute to the protection against age-related skin pathologies, including skin cancer, such as non-melanoma skin cancer, in addition to their involvement in skin rejuvenation.
* geriatrics
* hospital medicine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880728
}}
{{medline-entry
|title=Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31894551


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Cardiac Surgical Procedures
* Frail Elderly
* Frailty
* Geriatric Assessment
* Humans
* Percutaneous Coronary Intervention
* Risk Assessment
* Transcatheter Aortic Valve Replacement
|keywords=* Cardiac surgery
* Comprehensive geriatric assessment
* Disability
* Elderly
* Frailty
* Geriatrics
* Surgical risk scores
* TAVI
|full-text-url=https://sci-hub.do/10.1007/978-3-030-33330-0_11
}}
{{medline-entry
|title=Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31745004


===Keywords===
|mesh-terms=* Aged
Cellular senescence; Senolytics; Skin aging
* Clinical Competence
* Education, Medical, Graduate
* Educational Measurement
* Female
* Geriatric Assessment
* Geriatrics
* Humans
* Male
* Pilot Projects
* United Kingdom
|keywords=* Comprehensive geriatric assessment
* development
* entrustable professional capabilities
* objective structured clinical examination
* summative assessment
|full-text-url=https://sci-hub.do/10.4103/efh.EfH_111_18
}}
{{medline-entry
|title=How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31728682


==Age-related altering temporal processing and binaural interaction functions in normal hearing individuals: Observational and cross-sectional study.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
This study aimed to investigate the temporal processing and binaural interaction functions of central auditory processing tests according to the anatomical localizations of young and elderly individuals. It also sought to evaluate the relationships between the same individuals' central auditory processing tests. This observational and cross-sectional study included individuals with normal hearing between 18 and 30 and 60-75 years of age, who were referred to as the young group and the elderly group, respectively. The evaluation of the central auditory processing tests was completed using the frequency pattern test, duration pattern test, masking level difference test, and random gap detection test. Furthermore, speech discrimination and speech in noise scores were analyzed for both groups. Statistically significant differences were identified between the groups' scores for the speech in noise test, masking level difference test, random gap detection test, frequency pattern test, and duration pattern test (p < 0.05). A statistically significant relationship was observed between the age and the results of the central auditory processing tests (p < 0.05). When compared to younger individuals, elderly individuals presented with declined temporal sequences, temporal resolutions, and binaural interaction skills.
* Comorbidity
* Female
* Genital Neoplasms, Female
* Geriatric Assessment
* Gynecology
* Humans
* Hysterectomy
* Japan
* Lymph Node Excision
* Oncologists
* Surveys and Questionnaires
|keywords=* Comprehensive geriatric assessment
* Elderly
* Geriatrics
* Gynecologic cancer
|full-text-url=https://sci-hub.do/10.1007/s10147-019-01574-z
}}
{{medline-entry
|title=Validation of the Pictorial Fit-Frail Scale in a memory clinic setting.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524122


===MeSH Terms===
-


===Keywords===
|keywords=* aging
Aging; Duration pattern; Elderly; Frequency pattern; Gap detection; Masking level difference
* dementia
* frail elderly
* frailty
* psychometrics
|full-text-url=https://sci-hub.do/10.1017/S1041610219000905
}}
{{medline-entry
|title=Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31467370


==Oxidative Stress at the Crossroads of Aging, Stroke and Depression.==
|mesh-terms=* Activities of Daily Living
===Abstract===
* Aged
Epidemiologic studies have shown that in the aging society, a person dies from stroke every 3 minutes and 42 seconds, and vast numbers of people experience depression around the globe. The high prevalence and disability rates of stroke and depression introduce enormous challenges to public health. Accumulating evidence reveals that stroke is tightly associated with depression, and both diseases are linked to oxidative stress (OS). This review summarizes the mechanisms of OS and OS-mediated pathological processes, such as inflammation, apoptosis, and the microbial-gut-brain axis in stroke and depression. Pathological changes can lead to neuronal cell death, neurological deficits, and brain injury through DNA damage and the oxidation of lipids and proteins, which exacerbate the development of these two disorders. Additionally, aging accelerates the progression of stroke and depression by overactive OS and reduced antioxidant defenses. This review also discusses the efficacy and safety of several antioxidants and antidepressants in stroke and depression. Herein, we propose a crosstalk between OS, aging, stroke, and depression, and provide potential therapeutic strategies for the treatment of stroke and depression.
* Aged, 80 and over
* Aging
* Cognition
* Female
* Geriatrics
* Humans
* Hyponatremia
* Male
* Mental Status and Dementia Tests
* Middle Aged
* Motor Activity
* Sodium


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715723
-
}}
{{medline-entry
|title=Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31412787


===Keywords===
|mesh-terms=* Accidental Falls
aging; antioxidant; depression; intracerebral hemorrhage; mitochondrial dysfunction; oxidative stress; stroke; subarachnoid hemorrhage
* Aged
* Aged, 80 and over
* Cohort Studies
* Emergency Service, Hospital
* Female
* Geriatric Assessment
* Health Status
* Hospitalization
* Humans
* Internal Medicine
* Length of Stay
* Male
* Mass Screening
* Patient Discharge
* Risk Assessment
|keywords=* CGA
* Cutoff
* Geriatrics
* ISAR
* Internal medicine
* Older in-patients
* Risk screening
* Sensitivity
* Specificity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694685
}}
==CHI3L1==


==Adherence to Beers Criteria in Geriatrics: A Retrospective Study in a Saudi Teaching Hospital.==
{{medline-entry
===Abstract===
|title=Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.
The aging process makes geriatric populations more prone to various chronic diseases. Such diseases require older patients to be on more medications than any other age group and make them more susceptible to adverse drug events related to potentially inappropriate medications (PIMs). To identify the prevalence of potentially inappropriate medications among older people and explore the most commonly prescribed PIMs in hospitalized patients. A retrospective study conducted in a large tertiary hospital among patients hospitalized in a 4 year period from January 2015 to December 2018. The 2019 Beers Criteria were used to assess PIMs in all inpatient prescribed medications focusing on the first class (i.e., drug/drug class to be avoided in older adults). The mean age was 75.17 ± 7.66 years. A total of 684 (80.6%) patients were prescribed at least one medication listed in the first-class category of the 2019 Beers Criteria. Top five drugs were proton pump inhibitors (40.3%), nonsteroidal anti-inflammatory drugs (10.2%), metoclopramide (9.3%), benzodiazepines (8.4%), and insulin (5.4%). The prevalence of PIMs is high among older patients admitted to the hospital. More efforts are needed to investigate the potential reasons and develop action plans to improve concordance to Beers Criteria among healthcare providers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949560


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Beers criteria; adherence; geriatrics; potential inappropriate medications
* Alzheimer’s disease
* Bioinformatics
* CHI3L1
* Chitinase
* NRGN
|full-text-url=https://sci-hub.do/10.1016/j.brainres.2020.147127
}}
==CHRNA7==


==Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPR  Activation and Behavior in C. elegans.==
{{medline-entry
===Abstract===
|title=Associations between genetic variations and global motion perception.
In C. elegans, expression of the UPR  transcription factor xbp-1s in neurons cell non-autonomously activates the UPR  in the intestine, leading to enhanced proteostasis and lifespan. To better understand this signaling pathway, we isolated neurons from animals expressing neuronal xbp-1s for transcriptomic analysis, revealing a striking remodeling of transcripts involved in neuronal signaling. We then identified signaling molecules required for cell non-autonomous intestinal UPR  activation, including the biogenic amine tyramine. Expression of xbp-1s in just two pairs of neurons that synthesize tyramine, the RIM and RIC interneurons, induced intestinal UPR  activation and extended longevity, and exposure to stress led to splicing and activation of xbp-1 in these neurons. In addition, we found that neuronal xbp-1s modulates feeding behavior and reproduction, dependent upon tyramine synthesis. XBP-1s therefore remodels neuronal signaling to coordinately modulate intestinal physiology and stress-responsive behavior, functioning as a global regulator of organismal responses to stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432227


===MeSH Terms===
|mesh-terms=* Adult
-
* Differential Threshold
* Female
* Genotype
* Humans
* Male
* Motion Perception
* Polymorphism, Single Nucleotide
* Receptors, Nicotinic
* Sensory Thresholds
* Young Adult
* alpha7 Nicotinic Acetylcholine Receptor
|keywords=* Aging
* CHRNA7
* Cholinergic system
* Coherent motion
* Genetic variations
|full-text-url=https://sci-hub.do/10.1007/s00221-019-05627-7
}}
==CHSY1==


===Keywords===
{{medline-entry
C. elegans; ER stress; aging; neurobiology; proteostasis; signaling; stress response
|title=Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754016


==Age- and gender-associated differences in the sleepy brain's electroencephalogram.==
|mesh-terms=* Age Factors
===Abstract===
* Animals
In eyes closed condition, an increase of sleepiness level is associated with a decrease of the spectral electroencephalographic (EEG) power in the fast frequency rage (i.e., alpha activity) and with an increase of the power in the slow frequency range (i.e., theta activity). It was suggested that the changes in the fast and slow frequency ranges might determine two - the earlier and later - drowsiness stages preceding sleep onset, respectively. We tested whether such spectral EEG signatures of sleepiness vary with age or gender. The EEG signal was recorded with two-h intervals in 48 volunteers (15-67 years, 27 females) deprived from sleep between Friday evening to Sunday evening. The EEG signatures of sleepiness were calculated by the expressing each EEG spectrum as a deviation from the initial (Friday evening) EEG spectrum. The age- and gender-specific variation in such signatures was found. Only the pattern of age-associated variation changed with an increase of sleepiness level. Two-stage response to the increase of sleepiness was confirmed, but only in younger study participants. Subjective sleepiness was associated with neither age nor gender. In sleep deprivation research, the accounting for the age- and gender-specific variation in the spectral EEG measures of drowsiness might be recommended. The results did not reveal any disturbance of motivational function of subjective sleepiness in older study participants.
* Apoptosis
* Chondroitin Sulfates
* Female
* Glucuronosyltransferase
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Multifunctional Enzymes
* Mutation
* N-Acetylgalactosaminyltransferases
* Neurodegenerative Diseases
* Neurons
* Protein Processing, Post-Translational
* Proteins
* Retinal Degeneration
|keywords=* aging
* chondroitin sulfate synthase
* hippocampus
* inflammation
* mouse
* myeloid cells
* neurodegeneration
* retina
* retinal pigment epithelium
* subretinal space
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944401
}}
==CISD2==


===MeSH Terms===
{{medline-entry
-
|title=[[CISD2]] Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33005144


===Keywords===
aging; alertness; alpha attenuation; alpha rhythm; drowsiness; gender; spectral EEG


==Circular RNAs: Promising Biomarkers for Age-related Diseases.==
|keywords=* CISD2
===Abstract===
* M1/M2 microglia polarization
Aging is a complex biological process closely linked with the occurrence and development of age-related diseases. Despite recent advances in lifestyle management and drug therapy, the late diagnosis of these diseases causes severe complications, usually resulting in death and consequently impacting social economies. Therefore, the identification of reliable biomarkers and the creation of effective treatment alternatives for age-related diseases are needed. Circular RNAs (circRNAs) are a novel class of RNA molecules that form covalently closed loops capable of regulating gene expression at multiple levels. Several studies have reported the emerging functional roles of circRNAs in various conditions, providing new perspectives regarding cellular physiology and disease pathology. Notably, accumulating evidence demonstrates the involvement of circRNAs in the regulation of age-related pathologies, including cardio-cerebrovascular disease, neurodegenerative disease, cancer, diabetes, rheumatoid arthritis, and osteoporosis. Therefore, the association of circRNAs with these age-related pathologies highlights their potential as diagnostic biomarkers and therapeutic targets for better disease management. Here, we review the biogenesis and function of circRNAs, with a special focus on their regulatory roles in aging-related pathologies, as well as discuss their potential as biological biomarkers and therapeutic targets for these diseases.
* aging
* anti-inflammatory effects
* neurodegenerative disease and dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479185
}}
==CIT==


===MeSH Terms===
{{medline-entry
-
|title=Effect of sex on aging-related decline of dopamine transporter in healthy subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33052524


===Keywords===
age-related diseases; aging; biomarker; circRNAs


==PsychoAge and SubjAge: development of deep markers of psychological and subjective age using artificial intelligence.==
|keywords=* 123I-FP-CIT
===Abstract===
* Aging
Aging clocks that accurately predict human age based on various biodata types are among the most important recent advances in biogerontology. Since 2016 multiple deep learning solutions have been created to interpret facial photos, omics data, and clinical blood parameters in the context of aging. Some of them have been patented to be used in commercial settings. However, psychological changes occurring throughout the human lifespan have been overlooked in the field of "deep aging clocks". In this paper, we present two deep learning predictors trained on social and behavioral data from Midlife in the United States (MIDUS) study: (a) PsychoAge, which predicts chronological age, and (b) SubjAge, which describes personal aging rate perception. Using 50 distinct features from the MIDUS dataset these models have achieved a mean absolute error of 6.7 years for chronological age and 7.3 years for subjective age. We also show that both PsychoAge and SubjAge are predictive of all-cause mortality risk, with SubjAge being a more significant risk factor. Both clocks contain actionable features that can be modified using social and behavioral interventions, which enables a variety of aging-related psychology experiment designs. The features used in these clocks are interpretable by human experts and may prove to be useful in shifting personal perception of aging towards a mindset that promotes productive and healthy behaviors.
* Dopamine plasma membrane transport proteins
* SPECT
* Sex
|full-text-url=https://sci-hub.do/10.1007/s12149-020-01538-8
}}
{{medline-entry
|title=The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32184717


===MeSH Terms===
-


===Keywords===
|keywords=* SPECT
aging clock; artificial intelligence; deep learning; psychology of aging; subjective age
* Wechsler Adult Intelligence Scale
* aging
* cognitive function
* dopamine transporter
* verbal function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058549
}}
==CLEC3B==


==Are Loneliness and Social Isolation Associated with Quality of Life in Older Adults? Insights from Northern and Southern Europe.==
{{medline-entry
===Abstract===
|title=[[CLEC3B]] p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.
Loneliness and social isolation have detrimental effects on health in old age; however, the prospective associations with quality of life (QoL) remain unclear. Furthermore, despite the existence of a European north-south gradient in the distribution of loneliness and social isolation, little is known whether the associations are context-specific. We investigated the relationships between loneliness, social isolation and QoL of older adults residing in the North (Sweden) and South (Spain) of Europe. Study sample consisted of 2995 Swedish and 4154 Spanish older adults who participated in waves six and seven of the Study on Health, Aging and Retirement in Europe (SHARE). Loneliness and social isolation were measured at the baseline, and QoL was measured at the baseline and follow-up using CASP-12. Prospective associations were assessed via multivariate linear regression. In Sweden, subjects with higher vs. lower loneliness had 1.01 (95% CI: -1.55, -0.40) units lower QoL, while every standard deviation increase in social isolation was associated with a 0.27 (95% CI: -0.42, -0.09)-unit decrease in QoL. In Spain, every standard deviation increase in social isolation was associated with a 0.66 (95% CI: -1.11, -0.22)-unit decrease in QoL. The association was stronger in subjects aged ≤65 years old and those with no chronic diseases. The association with loneliness was not statistically significant in Spain. Loneliness and social isolation are prospectively associated with decreased QoL among older adults, yet the associations are contextually bound. Future interventions should target both exposures, among others, in order to increase QoL in this group.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570938


===MeSH Terms===
-


===Keywords===
|keywords=*
SHARE; aging; loneliness; prospective studies; quality of life; social isolation
          APOE
       
*
          CLEC3B
       
* Aging
* Human genetics
* Human health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494029
}}
==COL1A1==


==Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3.==
{{medline-entry
===Abstract===
|title=Remodeling process in bone of aged rats in response to resistance training.
We have recently demonstrated that c-Jun N-terminal kinase 3 (JNK3) is a key modulator of the enhanced osteogenic potential of stem cells derived from children when compared to those derived from adults. In this study, we formulated a JNK3-activator nanoparticle (JNK3*) that recapitulates the immense osteogenic potential of juvenile cells in adult stem cells by facilitating JNK3 activation. Moreover, we aimed to functionalize a collagen-based scaffold by incorporating the JNK3* in order to develop an advanced platform capable of accelerating bone healing by recruitment of host stem cells. Our data, in vitro and in vivo, demonstrated that the immense osteogenic potential of juvenile cells could be recapitulated in adult stem cells by facilitating JNK3 activation. Moreover, our results revealed that the JNK3* functionalized 3D scaffold induced the fastest bone healing and greatest blood vessel infiltration when implanted in critical-size rat calvarial defects in vivo. JNK3*scaffold fastest bone healing in vivo was associated with its capacity to recruit host stem cells to the site of injury and promote angiogenic-osteogenic coupling (e.g. Vegfa, Tie1, Runx2, Alp and Igf2 upregulation). In summary, this study has demonstrated the potential of harnessing knowledge of age-altered stem cell mechanobiology in order to develop a materials-based functionalization approach for the repair of large tissue defects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32593709


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Aging
* Animals
* Bone Remodeling
* Gene Expression Regulation
* Male
* Physical Conditioning, Animal
* RNA, Messenger
* Random Allocation
* Rats
* Rats, Wistar
* Resistance Training
|keywords=* Aging
* Bone homeostasis
* Function
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118008
}}
==COL3A1==


===Keywords===
{{medline-entry
Aging; Bone healing; Mechanobiology; Scaffold; Therapeutic; jnk3
|title=Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31864349


==The Effects of Low-Intensity Multimodal Proprioceptive Exercise on Cognitive Function in Older Adults.==
|mesh-terms=* Aging
===Abstract===
* Animals
Physical activity provides a number of physical and psychological benefits. Multimodal proprioceptive exercise represents a useful balance-based exercise with the potential to reduce falls in older adults. Previous research has also indicated cognitive benefits following multimodal proprioceptive exercise in young and older adults. This study aimed to assess cognition and mood following 2 types of physical activity (multimodal proprioception vs yoga) compared with control (classroom-based) in healthy older adults. Nineteen older adults (Mage = 65, sex = 9 males) participated in this randomized controlled crossover trial. Participants completed a 20-minute multimodal proprioceptive exercise class, 20-minute yoga session, and 20-minute classroom-based control. Numeric working memory and mood were assessed before and immediately following each of the interventions. The multimodal proprioceptive intervention significantly reduced numeric working memory reaction time versus the yoga (P = .043) and control (P = .023) group. There were no differences found for accuracy or mood. These results indicate that multimodal proprioceptive exercise is worthy of further investigation as an alternative mode of exercise alongside the more traditional aerobic and strength-based exercise for healthy older adults.
* Breeding
* Defensins
* Endometrium
* Female
* Fibrosis
* Gene Expression
* Horses
* Inflammation
* Reverse Transcriptase Polymerase Chain Reaction
|keywords=* Defensin-β
* Endometrium
* Gene expression
* Immune-modulation
* Mare
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925900
}}
==COMT==


===MeSH Terms===
{{medline-entry
-
|title=The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32008855


===Keywords===
|mesh-terms=* Acetone
aging; cognition; mood; proprioception
* Aging
* Animals
* Behavior
* Biogenic Monoamines
* Capsaicin
* Chronic Pain
* Disease Models, Animal
* Male
* Mice, Inbred C57BL
* Peripheral Nerve Injuries
* Physical Stimulation
* Prefrontal Cortex
* Sensory Thresholds
|keywords=* Geriatric pain
* Healthy aging
* Mice
* Sensory thresholds
* Supraspinal plasticity
* Tonic and chronic pain response
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.018
}}
==COPE==


==Peripheral visual perception during natural overground dual-task walking in older and younger adults.==
{{medline-entry
===Abstract===
|title=Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the [[COPE]]-study.
Little is known about the neurophysiological processes underlying visual processing during active behavior and how these change over the life span. This study investigated early (P1) and later (P3) event-related potentials of the electroencephalogram associated with visual perception in older and younger adults while sitting, standing, and walking. While sitting and standing, accurate performance in both groups was not associated with event-related potential characteristics. During walking, in contrast, prolonged latencies and reduced amplitudes of the P1 were related to slower responses and increased misses, respectively. No covariations of behavior and P3 characteristics were observed. However, prolonged P3 latencies with increasing motor task complexity were present for both age groups, and reduced amplitudes while walking were replicated in younger participants. Older participants were more affected by walking in general as reflected in slower walking speeds as well as reduced accuracy and relative P1 amplitudes. These results provide further insights into cognitive-motor interference during natural walking in younger and older adults on early attentional-perceptual processing stages, even for simple additional visual tasks.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272897


===MeSH Terms===
-


===Keywords===
|keywords=* Cognitive function
Aging; Dual-task walking; EEG; MoBI; Peripheral visual perception
* End stage renal disease
* Geriatric assessment
* Geriatrics
* Older patients
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147053
}}
==CORT==


==Effects of [i]Cudrania tricuspidata[/i] on anti-senescence in high glucose-treated endothelial cells via the Akt/p53/p21 pathway.==
{{medline-entry
===Abstract===
|title=Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.
The roles of [i]Cudrania tricuspidata[/i] (CT) in the prevention of senescence and the underlying mechanisms have not been elucidated. In a high glucose (HG)-induced senescent endothelial cell (EC) culture, CT (20 µg/ml) reduced the number of senescence-associated β-galactosidase-positive cells by 8.3% compared with the control group and increased the expression of p-Sirt1 by more than twofold compared with the control group. Moreover, 20 μg/ml CT treatment doubled the activity of p-Akt, which was inhibited by HG, compared with the control group. In addition, CT treatment decreased the expression of p53, p21, and Rb, which was increased by HG. Overall, CT delays HG-induced senescence via the Akt/p53/p21 pathway, suggesting its potential as a functional agent for the protection of ECs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33075214


===MeSH Terms===
-


===Keywords===
|keywords=* aging
Akt/p53/p21; Cudrania tricuspidata; endothelial cell; senescence
* body composition
* energy metabolism
* metabolism-related hormone
* sex differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571994
}}
{{medline-entry
|title=Effects of age and social isolation on murine hippocampal biochemistry and behavior.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866520


==A case report of traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) in a 21-year-old.==
===Abstract===
We present an unusual case of a persistent solitary left palatoglossal ulcer with no history of trauma or associated risk factors. A TUGSE lesion, which mimics that of malignancy, must always be noted as a differential even in risk factor absence.


===MeSH Terms===
|keywords=* Aging
-
* Hippocampus
* Inflammation
* Memory
* Serotonin
* Social isolation
* Stress
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111337
}}
{{medline-entry
|title=Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32669383


===Keywords===
TUGSE; Ulceration; carcinoma; dentistry; geriatrics; maxillofacial


==Differential Brain Activity in Regions Linked to Visuospatial Processing During Landmark-Based Navigation in Young and Healthy Older Adults.==
|keywords=* Alzheimer’s disease
===Abstract===
* aging
Older adults have difficulties in navigating unfamiliar environments and updating their wayfinding behavior when faced with blocked routes. This decline in navigational capabilities has traditionally been ascribed to memory impairments and dysexecutive function, whereas the impact of visual aging has often been overlooked. The ability to perceive visuospatial information such as salient landmarks is essential to navigating efficiently. To date, the functional and neurobiological factors underpinning landmark processing in aging remain insufficiently characterized. To address this issue, functional magnetic resonance imaging (fMRI) was used to investigate the brain activity associated with landmark-based navigation in young and healthy older participants. The performances of 25 young adults (μ = 25.4 years, [i]σ[/i] = 2.7; seven females) and 17 older adults (μ = 73.0 years, [i]σ[/i] = 3.9; 10 females) were assessed in a virtual-navigation task in which they had to orient using salient landmarks. The underlying whole-brain patterns of activity as well as the functional roles of specific cerebral regions involved in landmark processing, namely the parahippocampal place area (PPA), the occipital place area (OPA), and the retrosplenial cortex (RSC), were analyzed. Older adults' navigational abilities were overall diminished compared to young adults. Also, the two age groups relied on distinct navigational strategies to solve the task. Better performances during landmark-based navigation were associated with increased neural activity in an extended neural network comprising several cortical and cerebellar regions. Direct comparisons between age groups revealed that young participants had greater anterior temporal activity. Also, only young adults showed significant activity in occipital areas corresponding to the cortical projection of the central visual field during landmark-based navigation. The region-of-interest analysis revealed an increased OPA activation in older adult participants during the landmark condition. There were no significant between-group differences in PPA and RSC activations. These preliminary results hint at the possibility that aging diminishes fine-grained information processing in occipital and temporal regions, thus hindering the capacity to use landmarks adequately for navigation. Keeping sight of its exploratory nature, this work helps towards a better comprehension of the neural dynamics subtending landmark-based navigation and it provides new insights on the impact of age-related visuospatial processing differences on navigation capabilities.
* cognitive function
* enzyme regulation
* inflammation
* neurosteroid
* progesterone
* steroid hormones
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529050
}}
{{medline-entry
|title=Sex- and age-dependent differences in the hormone and drinking responses to water deprivation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31967852


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Animals
* Arginine Vasopressin
* Behavior, Animal
* Dehydration
* Drinking
* Female
* Male
* Rats, Wistar
* Sex Factors
* Sodium Chloride
* Subfornical Organ
* Water Deprivation
|keywords=* aging
* hormonal response
* sex differences
* sodium appetite
* thirst
|full-text-url=https://sci-hub.do/10.1152/ajpregu.00303.2019
}}
{{medline-entry
|title=Ontogeny of the adrenocortical response in an extremely altricial bird.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545013


===Keywords===
|mesh-terms=* Adrenal Glands
fMRI; healthy aging; landmark; scene-selective regions; spatial navigation
* Aging
* Animals
* Corticosterone
* Female
* Hypothalamo-Hypophyseal System
* Male
* Parrots
* Restraint, Physical
* Stress, Physiological
|keywords=* Venezuela
* adrenocortical
* altricial
* birds
* corticosterone
* glucocorticoid
* hypothalamic-pituitary-adrenal axis
* ontogeny
* parrots
* stress
|full-text-url=https://sci-hub.do/10.1002/jez.2317
}}
==CP==


==Human Brain Ages With Hierarchy-Selective Attenuation of Prediction Errors.==
{{medline-entry
===Abstract===
|title=A Life Course Perspective on Growing Older With Cerebral Palsy.
From the perspective of predictive coding, our brain embodies a hierarchical generative model to realize perception, which proactively predicts the statistical structure of sensory inputs. How are these predictive processes modified as we age? Recent research suggested that aging leads to decreased weighting of sensory inputs and increased reliance on predictions. Here we investigated whether this age-related shift from sensorium to predictions occurs at all levels of hierarchical message passing. We recorded the electroencephalography responses with an auditory local-global paradigm in a cohort of 108 healthy participants from 3 groups: seniors, adults, and adolescents. The detection of local deviancy seems largely preserved in older individuals at earlier latency (including the mismatch negativity followed by the P3a but not the reorienting negativity). In contrast, the detection of global deviancy is clearly compromised in older individuals, as they showed worse task performance and attenuated P3b. Our findings demonstrate that older brains show little decline in sensory (i.e., first-order) prediction errors but significant diminution in contextual (i.e., second-order) prediction errors. Age-related deficient maintenance of auditory information in working memory might affect whether and how lower-level prediction errors propagate to the higher level.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33213304


===MeSH Terms===
-


===Keywords===
|keywords=* aging
aging; auditory perception; electroencephalography (EEG); prediction errors; predictive coding
* cerebral palsy
* midlife
* neurological disorders
* neurology
* qualitative descriptive
|full-text-url=https://sci-hub.do/10.1177/1049732320971247
}}
{{medline-entry
|title=The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32750317


==A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy.==
===Abstract===
Osteoarthritis (OA) is a common and debilitating joint disease which develops and progresses with age. Despite extensive research into the disease, potent disease-modifying drugs remain elusive. Changes to the character and function of chondrocytes of the articular cartilage underly the pathogenesis of OA. A recently emerging facet of chondrocyte biology that has been implicated in OA pathogenesis is the role of circadian rhythms, and the cellular clock which governs rhythmic gene transcription. Here, we review the role of the chondrocyte's cellular clock in governing normal homeostasis, and explore the wide range of consequences that contribute to OA development when the clock is dysregulated by aging and other factors. Finally, we explore how harnessing this understanding of clock mechanics in aging and OA can be translated into novel treatment strategies, or 'chronotherapies', for patients.


===MeSH Terms===
|keywords=* Aging
-
* Alzheimer's disease
* Choroid plexus
* Development
* Multiple sclerosis
* Neuroprotection
|full-text-url=https://sci-hub.do/10.1016/j.bbamem.2020.183430
}}
{{medline-entry
|title=The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717457


===Keywords===
Aging; Chondrocyte; Circadian rhythms; Osteoarthritis; Translation


==Age-related impairment of autophagy in cervical motor neurons.==
|keywords=* Collagen
===Abstract===
* D-galactose
Neuromuscular dysfunction is common in old age. Damaged cytoplasmic structures aggregate with aging, especially in post-mitotic cells like motor neurons. Autophagy is a ubiquitous cell process that aids in the clearance of damaged aggregates. Accordingly, we hypothesized that autophagy is impaired in old age, contributing to neuromuscular dysfunction via an effect in motor neurons. Autophagy flux may be impaired as a result of deficits in the initiation, elongation or degradation phases. Changes in the expression levels of core proteins necessary for each of the autophagy phases were evaluated by Western blotting in the cervical spinal cord (segments C2-C6 corresponding to the phrenic motor pool) of adult male and female mice at 6-, 18-, and 24-months of age (reflecting 100%, 90% and 75% survival, respectively). There was no evidence of an effect of age on the expression of the autophagy markers Beclin-1 (Becn-1; initiation), ATG7 and ATG5/12 complex (elongation) or LC3 (elongation/degradation). Reduced p62 expression (a marker of degradation) was evident in the cervical spinal cord of adult mice at 18-months compared to 24-months. Accordingly, expression of LC3 and p62 in motor neurons was analyzed using immunofluorescence and confocal microscopy in separate animals. LC3 and p62 immunoreactivity was evident in the gray matter with minimal expression in the white matter across all age groups. A mixed linear model with animal as a random effect was used to compare relative LC3 and p62 expression in motor neurons to gray matter across age groups. Expression of both LC3 and p62 was higher in choline acetyl transferase (ChAT)-positive motor neurons (~2-3 fold vs. gray matter). Across age groups, there were differences in the relative expression of LC3 (F  = 7.59, p < 0.01) and p62 (F  = 8.00, p < 0.01) in cervical motor neurons. LC3 expression in motor neurons increased ~20% by 24-months of age in both male and female mice. p62 expression in motor neurons increased ~70% by 18-months compared to 6-months with no further changes by 24-months of age in male mice. p62 expression did not change across age groups in female mice, and was ~20% higher than in males. Our findings highlight important changes in autophagy pathways that likely contribute to the development of aging-related neuromuscular dysfunction in mice. At 18-months of age, increased autophagosome clearance (reduced p62 expression) appears to be a global effect not restricted to motor neurons. By 24-months of age, increased expression of LC3 and p62 indicates impaired autophagy with autophagosome accumulation in cervical motor neurons.
* Elastin
* Skin aging
* Ultraviolet
|full-text-url=https://sci-hub.do/10.1016/j.jphotobiol.2020.111964
}}
{{medline-entry
|title=Model based strategies towards protein A resin lifetime optimization and supervision.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32709318


===MeSH Terms===
|mesh-terms=* Algorithms
-
* Chromatography
* Kinetics
* Least-Squares Analysis
* Ligands
* Models, Theoretical
* Principal Component Analysis
* Resins, Plant
* Staphylococcal Protein A
* Statistics as Topic
|keywords=* Cleaning procedures
* Hybrid modeling
* Multivariate data analysis
* Protein A chromatography
* Resin aging
* Resin lifetime
|full-text-url=https://sci-hub.do/10.1016/j.chroma.2020.461261
}}
{{medline-entry
|title=The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32658282


===Keywords===
|mesh-terms=* Aging
Aging; Autophagy; Motor neuron; Neuromuscular dysfunction; Spinal cord
* Animal Feed
* Animal Husbandry
* Animals
* Cattle
* Diet
* Dietary Supplements
* Ecosystem
* Female
* Poaceae
* Seasons
* Weather
|keywords=* beef cattle
* cow age
* environment
* supplement intake
* winter grazing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455287
}}
{{medline-entry
|title=Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536211


==A novel digital clock drawing test as a screening tool for perioperative neurocognitive disorders: A feasibility study.==
===Abstract===
We developed a digital clock drawing test (dCDT), an adaptation of the original pen and paper clock test, that may be advantageous over previous dCDTs in the perioperative environment. We trialled our dCDT on a tablet device in the preoperative period to determine the feasibility of administration in this setting. To assess the clinical utility of this test, we examined the relationship between the performance on the test and compared derived digital clock measures with the 4 A's Test (4AT), a delirium and cognition screening tool. We recruited a sample of 102 adults aged 65 years and over presenting for elective surgery in a single tertiary hospital. Participants completed the 4AT, followed by both command and copy clock conditions of the dCDT. We recorded time-based clock-drawing metrics, alongside clock replications scored using the Montreal Cognitive Assessment (MoCA) clock scoring criteria. The dCDT had an acceptance rate of 99%. After controlling for demographic variables and prior tablet use, regression analyses showed higher 4AT scores were associated with greater dCDT time (seconds) for both command (β=8.2, p=0.020) and copy clocks (β=12, p=0.005) and lower MoCA-based clock scores in both command (OR=0.19, p=0.001) and copy conditions (OR=0.14, p=0.012). The digital clock drawing test is feasible to administer and is highly acceptable to older adults in a preoperative setting. We demonstrated a significant association between both the dCDT time and clock score metrics, with the established 4AT. Our results provide convergent validity of the dCDT in the preoperative setting.


===MeSH Terms===
|keywords=* Cyclophosphamide
-
* Decalepis hamiltonii
* premature ovarian failure
* reproductive performance
* reproductive senescence
* uterus
|full-text-url=https://sci-hub.do/10.1080/01480545.2020.1774773
}}
{{medline-entry
|title=Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31928429


===Keywords===
|mesh-terms=* Aging
aging; cognition; cognitive screening; feasibility; perioperative neurocognitive disorder
* Animals
* Apoptosis
* Asymptomatic Infections
* Brain
* Brain Diseases
* Clostridium Infections
* Clostridium perfringens
* Disease Models, Animal
* Feces
* Food Microbiology
* Gene Expression
* Humans
* Inflammation
* Intestines
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Organ Size
* Oxidative Stress
* Risk Factors
* Spleen
|keywords=* Clostridium perfringens
* brain damage
* brain disorder
* gut microbiota
|full-text-url=https://sci-hub.do/10.1089/fpd.2019.2677
}}
{{medline-entry
|title=The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31834321


==Aging and the encoding of changes in events: The role of neural activity pattern reinstatement.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
When encountering unexpected event changes, memories of relevant past experiences must be updated to form new representations. Current models of memory updating propose that people must first generate memory-based predictions to detect and register that features of the environment have changed, then encode the new event features and integrate them with relevant memories of past experiences to form configural memory representations. Each of these steps may be impaired in older adults. Using functional MRI, we investigated these mechanisms in healthy young and older adults. In the scanner, participants first watched a movie depicting everyday activities in a day of an actor's life. They next watched a second nearly identical movie in which some scenes ended differently. Crucially, before watching the last part of each activity, the second movie stopped, and participants were asked to mentally replay how the activity previously ended. Three days later, participants were asked to recall the activities. Neural activity pattern reinstatement in medial temporal lobe (MTL) during the replay phase of the second movie was associated with detecting changes and with better memory for the original activity features. Reinstatements in posterior medial cortex (PMC) additionally predicted better memory for changed features. Compared to young adults, older adults showed a reduced ability to detect and remember changes and weaker associations between reinstatement and memory performance. These findings suggest that PMC and MTL contribute to change processing by reinstating previous event features, and that older adults are less able to use reinstatement to update memory for changed features.
* Anti-Retroviral Agents
* Disease Management
* Disease Transmission, Infectious
* Female
* HIV Infections
* Humans
* Male
* Medication Adherence
* Middle Aged
* Pharmacists
* Professional Role
* Treatment Outcome
|keywords=* Aging
* Antiretroviral therapy
* Clinical pharmacist
* Comorbidities
* HIV
|full-text-url=https://sci-hub.do/10.24875/AIDSRev.19000089
}}
{{medline-entry
|title=A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31787527


===MeSH Terms===
|mesh-terms=* Adult
-
* Aging
* Case-Control Studies
* Cross-Sectional Studies
* Humans
* Middle Aged
* Pain
* Pain Measurement
* Pancreatitis, Chronic
* Sex Factors
|keywords=* Central sensitization
* Chronic pancreatitis
* Nociception
* Pain
|full-text-url=https://sci-hub.do/10.1016/j.pan.2019.11.007
}}
{{medline-entry
|title=Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31812699


===Keywords===
change comprehension; cognitive aging; episodic memory; event cognition; representational similarity analysis


==Conditional reprograming culture conditions facilitate growth of lower grade glioma models.==
|keywords=* Aging
===Abstract===
* DXA
The conditional reprogramming cell culture method was developed to facilitate growth of senescence-prone normal and neoplastic epithelial cells, and involves co-culture with irradiated fibroblasts and the addition of a small molecule Rho kinase (ROCK) inhibitor. The aim of this study was to determine whether this approach would facilitate the culture of compact low grade gliomas. We attempted to culture 4 pilocytic astrocytomas, 2 gangliogliomas, 2 myxopapillary ependymomas, 2 anaplastic gliomas, 2 difficult-to-classify low grade neuroepithelial tumors, a desmoplastic infantile ganglioglioma, and an anaplastic pleomorphic xanthoastrocytoma using a modified conditional reprogramming cell culture approach. Conditional reprogramming resulted in robust increases in growth for a majority of these tumors, with fibroblast conditioned media and ROCK inhibition both required. Switching cultures to standard serum containing media, or serum free neurosphere conditions, with or without ROCK inhibition, resulted in decreased proliferation and induction of senescence markers. ROCK inhibition and conditioned media both promoted Akt and Erk1/2 activation. Several cultures, including one derived from a NF1-associated pilocytic astrocytoma (JHH-NF1-PA1) and one from a BRAF p.V600E mutant anaplastic pleomorphic xanthoastrocytoma (JHH-PXA1), exhibited growth sufficient for preclinical testing in vitro. In addition, JHH-NF1-PA1 cells survived and migrated in larval zebrafish orthotopic xenografts, while JHH-PXA1 formed orthotopic xenografts in mice histopathologically similar to the tumor from which it was derived. These studies highlight the potential for the conditional reprogramming cell culture method to promote the growth of glial and glioneuronal tumors in vitro, in some cases enabling the establishment of long-term culture and in vivo models.
* Fracture prevention
* Injury/fracture healing
* Osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037571
}}
{{medline-entry
|title=Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642397


===MeSH Terms===
-


===Keywords===
|keywords=* Clinical pharmacy
BRAFV600E; Conditional reprogramming; NF1; Senescence; low grade glioma
* geriatrics
* inpatients
* polypharmacy
* risk stratification
|full-text-url=https://sci-hub.do/10.1080/17843286.2019.1683128
}}
{{medline-entry
|title=Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31622731


==The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan.==
|mesh-terms=* Aging
===Abstract===
* Amino Acids
It has been suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. Here instead, we tested using task-fMRI (n = 540, age 6-82 years) whether the functional foundations of successful episodic memory encoding adhere to a principle of lifespan continuity, shaped by developmental, structural, and evolutionary influences. We clustered regions of the cerebral cortex according to the shape of the lifespan trajectory of memory activity in each region so that regions showing the same pattern were clustered together. The results revealed that lifespan trajectories of memory encoding function showed a continuity through life but no evidence of age-specific mechanisms such as compensatory patterns. Encoding activity was related to general cognitive abilities and variations of grey matter as captured by a multi-modal independent component analysis, variables reflecting core aspects of cognitive and structural change throughout the lifespan. Furthermore, memory encoding activity aligned to fundamental aspects of brain organization, such as large-scale connectivity and evolutionary cortical expansion gradients. Altogether, we provide novel support for a perspective on memory aging in which maintenance and decay of episodic memory in older age needs to be understood from a comprehensive life-long perspective rather than as a late-life phenomenon only.
* Animals
* Body Weight
* Collagen
* Drosophila
* Fatty Acids
* Feeding Behavior
* Hydrogen Peroxide
* Longevity
* Molecular Weight
* Oxidative Stress
* Paraquat
|keywords=* Anti-aging
* Antioxidant activity
* Collagen
* Drosophila
* Royal jelly
|full-text-url=https://sci-hub.do/10.1016/j.fct.2019.110881
}}
==CPM==


===MeSH Terms===
{{medline-entry
-
|title=Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083842


===Keywords===
aging; development; encoding; fMRI; neuroimaging


==SIRT1 - a new mammalian substrate of nuclear autophagy.==
|keywords=* Aging
===Abstract===
* Anxiety
Macroautophagic/autophagic degradation of nuclear components (or nuclear autophagy) is a poorly understood area in autophagy research. We previously reported the nuclear lamina protein LMNB1 (lamin B1) as a nuclear autophagy substrate in primary human cells, stimulating the investigation of nuclear autophagy in the mammalian system. We recently reported the sirtuin protein SIRT1 as a new selective substrate of nuclear autophagy in senescence and aging. Upon senescence of primary human cells, SIRT1 degradation is mediated by a direct nuclear SIRT1-LC3 interaction, followed by nucleus-to-cytoplasm shuttling of SIRT1 and autophagosome-lysosome degradation. In vivo, SIRT1 is downregulated by lysosomes in hematopoietic and immune organs upon natural aging in mice and in aged human T cells. Our study identified another substrate of nuclear autophagy and suggests a new strategy to promote SIRT1-mediated health benefits by suppressing its autophagic degradation.
* Conditioned Pain Modulation
* Pain Catastrophizing
* Reliability
* Temporal Summation of Pain
|full-text-url=https://sci-hub.do/10.1093/pm/pnaa288
}}
{{medline-entry
|title=Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32072094


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Aging; SIRT1; nuclear autophagy; senescence; sirtuin
* CPM duration
* Conditioned pain modulation
* Conditioning stimulus
* Sex differences
* Test stimulus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004505
}}
{{medline-entry
|title=The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562994


==Circulating cell-free DNA species affect the risk of hepatocellular carcinoma in treated chronic hepatitis B patients.==
===Abstract===
Hepatocellular carcinoma (HCC) may still develop in chronic hepatitis B (CHB) patients even under effective long-term oral antiviral therapy, but its pathogenesis in the setting of long-standing inhibition of viral replication has not been completely elucidated. We investigated whether species of circulating cell-free DNA (cfDNA) may be involved in the process of hepatocarcinogenesis in treated CHB patients. Serum samples were obtained from HBeAg-negative CHB patients with (HCC cases, n=37) or without HCC development during the first 5 years of oral antiviral therapy (controls, n=74). HCC cases and controls were matched 1:2 for age, sex and platelets. Determination of different circulating cfDNA species (before HCC diagnosis in HCC cases) including total cfDNA quantity, levels of Alu repeat DNA and RNAse P coding DNA, copies of mitochondrial DNA and levels of 5-methyl-2'-deoxycytidine as indicator of DNA methylation was performed. HCC cases compared to controls had higher median levels of Alu247 (123 vs 69 genomic equivalent, P=0.042) and RNAse P coding DNA (68 vs 15 genomic equivalent, P<0.001). In contrast, median cfDNA concentration, Alu115 levels, Alu247/Alu115 ratio as an index of DNA integrity and mitochondrial DNA copies did not differ significantly between HCC cases and controls. Receiver operating characteristic curve analysis showed that levels RNAse P coding DNA offered good prediction of subsequent HCC development (c-statistic: 0.80, P<0.001). In conclusion, serum levels of RNAse P coding DNA are increased years before HCC diagnosis and could be potentially helpful in the prediction of the HCC risk in treated HBeAg-negative CHB patients.


===MeSH Terms===
|keywords=* Aging
-
* conditioned pain modulation
* meta-analysis
* pain modulation
* temporal summation
|full-text-url=https://sci-hub.do/10.1016/j.jpain.2019.09.005
}}
==CPNE1==


===Keywords===
{{medline-entry
cirrhosis; hepatitis B; liver cancer; senescence; therapy
|title=Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274830


==Inhibition of PAR-1 delays aging via activating AMPK in C. elegans.==
===Abstract===
The antagonistic pleiotropy theory of aging suggests that genes essential for growth and development are likely to modulate aging later in life. Previous studies in [i]C. elegans[/i] demonstrate that inhibition of certain developmentally essential genes during adulthood leads to significant lifespan extension. PAR-1, a highly conserved serine/threonine kinase, functions as a key cellular polarity regulator during the embryonic development. However, the role of PAR-1 during adulthood remains unknown. Here we show that inhibition of [i]par-1[/i] either by a temperature-sensitive mutant or by RNAi knockdown only during adulthood is sufficient to extend lifespan in [i]C. elegans[/i]. Inhibition of [i]par-1[/i] also improves healthspan, as indicated by increased stress resistance, enhanced proteotoxicity resistance, as well as reduced muscular function decline over time. Additionally, tissue-enriched RNAi knockdown analysis reveals that PAR-1 mainly functions in the epidermis to regulate lifespan. Further genetic epistatic and molecular studies demonstrate that the effect of [i]par-1[/i] on lifespan requires the AMP-activated protein kinase (AMPK), and RNAi knockdown of [i]par-1[/i] results in age-dependent AMPK activation and reduced lipid accumulation in the metabolic tissue. Taken together, our findings reveal a previously undescribed function of PAR-1 in adulthood, which will help to understand the molecular links between development and aging.


===MeSH Terms===
|keywords=* CPNE1
-
* U2AF1
* intron retention
* senescence
* splicing factor
|full-text-url=https://sci-hub.do/10.1111/acel.13276
}}
==CPT1A==


===Keywords===
{{medline-entry
AMPK; Caenorhabditis elegans; PAR-1; healthspan; longevity
|title=Alteration of fatty acid oxidation by increased [[CPT1A]] on replicative senescence of placenta-derived mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900237


==Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.==
===Abstract===
Ovarian aging leads to reproductive and endocrine dysfunction, causing the disorder of multiple organs in the body and even declined quality of offspring's health. However, few studies have investigated the changes in gene expression profile in the ovarian aging process. Here, we applied integrated bioinformatics to screen, identify, and validate the critical pathogenic genes involved in ovarian aging and uncover potential molecular mechanisms. The expression profiles of GSE84078 were downloaded from the Gene Expression Omnibus (GEO) database, which included the data from ovarian samples of 10 normal C57BL/6 mice, including old (21-22 months old, ovarian failure period) and young (5-6 months old, reproductive bloom period) ovaries. First, we filtered 931 differentially expressed genes (DEGs), including 876 upregulated and 55 downregulated genes through comparison between ovarian expression data from old and young mice. Functional enrichment analysis showed that biological functions of DEGs were primarily immune response regulation, cell-cell adhesion, and phagosome pathway. The most closely related genes among DEGs ([i]Tyrobp[/i], [i]Rac2[/i], [i]Cd14[/i], [i]Zap70[/i], [i]Lcp2[/i], [i]Itgb2[/i], [i]H2-Ab1[/i], and [i]Fcer1g[/i]) were identified by constructing a protein-protein interaction (PPI) network and consequently verified using mRNA and protein quantitative detection. Finally, the immune cell infiltration in the ovarian aging process was also evaluated by applying CIBERSORT, and a correlation analysis between hub genes and immune cell type was also performed. The results suggested that plasma cells and naïve CD4  T cells may participate in ovarian aging. The hub genes were positively correlated with memory B cells, plasma cells, M1 macrophages, Th17 cells, and immature dendritic cells. In conclusion, this study indicates that screening for DEGs and pathways in ovarian aging using bioinformatic analysis could provide potential clues for researchers to unveil the molecular mechanism underlying ovarian aging. These results could be of clinical significance and provide effective molecular targets for the treatment of ovarian aging.


===MeSH Terms===
|keywords=* CPT1A
-
* Fatty acid
* Mitochondria
* Placenta-derived mesenchymal stem cell
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941254
}}
==CPT1C==


===Keywords===
{{medline-entry
GEO database; bioinformatics; biomarker; immune cell infiltration; ovarian aging
|title=Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32632982


==Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.==
===Abstract===
Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in protein folding and ER stress has been implicated in bone mineralization. The role of ER stress in VSMC-mediated calcification is less clear. Approach and Results: mRNA expression of the ER stress markers PERK (PKR (protein kinase RNA)-like ER kinase), ATF (activating transcription factor) 4, ATF6, and Grp78 was detectable in human vessels with levels of PERK decreased in calcified plaques compared to healthy vessels. Protein deposition of Grp78/Grp94 was increased in the matrix of calcified arteries. Induction of ER stress accelerated human primary VSMC-mediated calcification, elevated expression of some osteogenic markers (Runx2, Osterix, ALP, BSP, and OPG), and decreased expression of SMC markers. ER stress potentiated extracellular vesicle (EV) release via SMPD3. EVs from ER stress-treated VSMCs showed increased Grp78 levels and calcification. Electron microscopy confirmed the presence of Grp78/Grp94 in EVs. siRNA knock-down of Grp78 decreased calcification. Warfarin-induced Grp78 and ATF4 expression in rat aortas and VSMCs and increased calcification in an ER stress-dependent manner via increased EV release. ER stress induces vascular calcification by increasing release of Grp78-loaded EVs. Our results reveal a novel mechanism of action of warfarin, involving increased EV release via the PERK-ATF4 pathway, contributing to calcification. This study is the first to show that warfarin induces ER stress and to link ER stress to cargo loading of EVs.


===MeSH Terms===
|keywords=* MRC-5 fibroblasts
-
* carnitine palmitoyltransferase 1C (CPT1C)
* cellular senescence
* lipidomics
* mitochondrial function
|full-text-url=https://sci-hub.do/10.1002/jcp.29906
}}
{{medline-entry
|title=Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32289751


===Keywords===
aging; arteries; endoplasmic reticulum; vascular calcification; warfarin


==Integrating music-based interventions with Gamma-frequency stimulation: Implications for healthy aging.==
|keywords=* carnitine palmitoyltransferase 1C
===Abstract===
* metabolic reprogramming
In recent years, music-based interventions (MBIs) have risen in popularity as a non-invasive, sustainable form of care for treating dementia-related disorders, such as Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD). Despite their clinical potential, evidence regarding the efficacy of MBIs on patient outcomes is mixed. Recently, a line of related research has begun to investigate the clinical impact of non-invasive Gamma-frequency (e.g., 40 Hz) sensory stimulation on dementia. Current work, using non-human-animal models of AD, suggests that non-invasive Gamma-frequency stimulation can remediate multiple pathophysiologies of dementia at the molecular, cellular, and neural-systems scales, and, importantly, improve cognitive functioning. These findings suggest that the efficacy of MBIs could, in theory, be enhanced by incorporating Gamma-frequency stimulation into current MBI protocols. In the current review, we propose a novel clinical framework for non-invasively treating dementia-related disorders that combines previous MBIs with current approaches employing Gamma-frequency sensory stimulation. We theorize that combining MBIs with Gamma-frequency stimulation could increase the therapeutic power of MBIs by simultaneously targeting multiple biomarkers of dementia, restoring neural activity that underlies learning and memory (e.g., Gamma-frequency neural activity, Theta-Gamma coupling), and actively engaging auditory and reward networks in the brain to promote behavioral change.
* mitochondria
* senescence
* stable transfection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202531
}}
==CPT2==


===MeSH Terms===
{{medline-entry
-
|title=The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32729662


===Keywords===
Alzheimer’s disease; Gamma stimulation; aging; dementia; music-based interventions; neural oscillations


==Associations of Lifestyle Factors With Cognition in Community-Dwelling Adults Aged 50 and Older: A Longitudinal Cohort Study.==
|keywords=* EGCG
===Abstract===
* free fatty acid
In the absence of an effective treatment to alter the progressive course of cognitive decline and dementia, identification of modifiable risk factors that could promote healthy cognitive aging has become a public health research priority. This study seeks to comprehensively determine the contemporaneous associations of a broad spectrum of time-varying modifiable lifestyle factors with age-related cognitive decline in a large population-based cohort of older adults. A total of 5,711 subjects aged 50 and older from the WHO Study on global AGEing and adult health (SAGE) in Shanghai were studied. Repeated measures of lifestyle factors and cognitive performance were conducted in 2009-2010 and 2014-2015. Linear random slope models were used to evaluate the contemporaneous associations between time-varying lifestyle factors and cognitive performance. Person-mean centering method was used to disaggregate the between- and within-person effects in the time-varying lifestyle factors in the random slope models. We found that higher vegetable and fruit consumption, as well as higher level of physical activity were positively associated with all cognitive domains. Body mass index (BMI) was negatively associated with all cognitive domains, whereas waist-to-hip ratio (WHR) was negatively associated with verbal fluency score only. Sedentary time was negatively associated with digit span score but positively associated with verbal fluency score. The between-person effects seem to be more dominant than within-person effects. Overall, our findings suggest better management of multiple lifestyle factors may protect against cognitive decline in later life. Higher vegetable and fruit consumption and physical activity are protective, whereas obesity is detrimental to cognitive decline in older adults. This study underpins the development of multi-domain lifestyle recommendations to promote healthy cognitive aging.
* high-fat dietary
* lifespan
* proteomics
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511879
}}
==CR1==


===MeSH Terms===
{{medline-entry
-
|title=Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32986668


===Keywords===
aging; cognitive decline; fruit; lifestyle; obesity; physical activity; sedentary time; vegetable


==Cross-country differences in age trends in alcohol consumption among older adults: a cross-sectional study of individuals aged 50 years and older in 22 countries.==
|keywords=* Aging
===Abstract===
* Alzheimer’s disease
Age-related changes in physiological, metabolic and medication profiles make alcohol consumption likely to be more harmful among older than younger adults. This study aimed to estimate cross-national variation in the quantity and patterns of drinking throughout older age, and to investigate country-level variables explaining cross-national variation in consumption for individuals aged 50 years and older. Cross-sectional observational study using previously harmonized survey data. Twenty-two countries surveyed in 2010 or the closest available year. A total of 106 180 adults aged 50 years and over. Cross-national variation in age trends were estimated for two outcomes: weekly number of standard drink units (SDUs) and patterns of alcohol consumption (never, ever, occasional, moderate and heavy drinking). Human Development Index and average prices of vodka were used as country-level variables moderating age-related declines in drinking. Alcohol consumption was negatively associated with age (risk ratio = 0.98; 95% confidence interval = 0.97, 0.99; P-value < 0.001), but there was substantial cross-country variation in the age-related differences in alcohol consumption [likelihood ratio (LR) test P-value < 0.001], even after adjusting for the composition of populations. Countries' development level and alcohol prices explained 31% of cross-country variability in SDUs (LR test P-value < 0.001) but did not explain cross-country variability in the prevalence of heavy drinkers. Use and harmful use of alcohol among older adults appears to vary widely across age and countries. This variation can be partly explained both by the country-specific composition of populations and country-level contextual factors such as development level and alcohol prices.
* middle aged
* neuroimaging
* single nucleotide
polymorphism
|full-text-url=https://sci-hub.do/10.3233/JAD-200444
}}
{{medline-entry
|title=The whale shark genome reveals how genomic and physiological properties scale with body size.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32753383


===MeSH Terms===
|mesh-terms=* Adaptation, Physiological
-
* Animals
* Base Sequence
* Body Size
* Genome
* Genomics
* Longevity
* Sharks
* Temperature
|keywords=* body size
* lifespan
* metabolic rate
* neural genes
* whale shark
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456109
}}
==CRABP2==


===Keywords===
{{medline-entry
Aging; alcohol; cross-cultural; development; drink; global; mixed model; multi-level; old age; price
|title=Preconception resveratrol intake against infertility: Friend or foe?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32273814


==What doesn't kill you makes you feel older: lifespan adversity and its association with subjective age among former prisoners of war.==
===Abstract===
: Subjective age (SA) is an indicator of aging that has been empirically associated with health impediments and hindered longevity. Studies show that adverse life events may result in relatively older SA, but have not addressed the differential contribution of life events across the lifespan and the course of posttraumatic psychopathology on the SA of aging survivors of extreme trauma.  : Filling this gap, the current study explored the differential contribution of (1) adverse experiences in various life-stages and (2) trajectories of posttraumatic stress disorder (PTSD) to the prediction of SA in a sample of former prisoners-of-war as they enter old age.  : A cohort of Israeli former prisoners-of-war of the 1973 Yom Kippur War ([i]N[/i] = 103) was assessed at four points throughout four decades after the war. A linear hierarchical regression was utilized to assess the contribution of negative life events during childhood, participation in other wars, combat exposure, suffering in captivity, life events since the war and the trajectories of PTSD for predicting SA 42-years post-repatriation.  : Lifespan adversity explained 50% of the variance in SA, with trajectories of PTSD making the largest contribution, followed by life events since the war. Negative life events in childhood added to the explained variance only when PTSD trajectories were accounted for. Exposure to combat, participation in additional wars and the severity of specific experiences during captivity did not reach significance, though the latter marginally contributed to the explained variance ([i]p[/i] [i]= [/i].069).  : This study demonstrates the importance of considering the prolongation of posttraumatic psychopathology together with life adversities and their differential implications when addressing SA after extreme trauma. The findings suggest that early life adversity may be a latent factor that increases vulnerability to posttraumatic premature aging processes.


===MeSH Terms===
|keywords=* aging
-
* assisted reproductive technology
* infertility
* resveratrol
* sirtuin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138940
}}
==CRBN==


===Keywords===
{{medline-entry
War trauma; aging process; captivity; negative life events; premature senescence
|title=Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332723


==Mediators and Moderators of the Association Between Perceived Stress and Episodic Memory in Diverse Older Adults.==
|mesh-terms=* Adaptor Proteins, Signal Transducing
===Abstract===
* Aging
Stress is a risk factor for numerous negative health outcomes, including cognitive impairment in late-life. The negative association between stress and cognition may be mediated by depressive symptoms, which separate studies have identified as both a consequence of perceived stress and a risk factor for cognitive decline. Pathways linking perceived stress, depressive symptoms, and cognition may be moderated by sociodemographics and psychosocial resources. The goal of this cross-sectional study was to identify modifying factors and enhance understanding of the mechanisms underlying the stress-cognition association in a racially and ethnically diverse sample of older adults. A linear regression estimated the association between perceived stress and episodic memory in 578 older adults (Mage = 74.58) in the Washington Heights-Inwood Columbia Aging Project. Subsequent models tested whether depressive symptoms mediated the stress-memory relationship and whether sociodemographics (gender, race, and ethnicity) or perceived control moderated these pathways. Independent of sociodemographics and chronic diseases, greater perceived stress was associated with worse episodic memory. This relationship was mediated by more depressive symptoms. Higher perceived control buffered the association between stress and depressive symptoms. There was no significant moderation by gender, race, or ethnicity. Depressive symptoms may play a role in the negative association between perceived stress and cognition among older adults; however, longitudinal analyses and studies using experimental designs are needed. Perceived control is a modifiable psychological resource that may offset the negative impact of stress.
* Aniline Compounds
* Animals
* Blood Platelets
* Cell Line
* Cellular Senescence
* Female
* Humans
* Male
* Mice
* Mice, Transgenic
* Models, Animal
* Primary Cell Culture
* Proteolysis
* Sulfonamides
* Ubiquitin-Protein Ligases
* bcl-X Protein


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181703
-
}}
==CRP==


===Keywords===
{{medline-entry
Cognitive aging; Depressive symptoms; Psychological stress; Sense of control
|title=Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33284965


==Testing a Proactive Model of Successful Aging Among Older Adults in Costa Rica and Spain.==
===Abstract===
The purpose of this study is to examine successful aging among Spanish-speaking older adults in Costa Rica and in Spain using the proactive framework proposed by Kahana et al. (2014). More specifically, we hypothesized that older adults' life satisfaction would be positively associated with the frequency and perceived level of social support, spirituality/having purpose in life, and the use of proactive physical, cognitive, and social self-care behaviors. Our results confirmed these hypotheses, not only for the overall group of participants, but also separately for older adults in Costa Rica and in Spain. The present study contributes to the literature of successful aging among older adults, by examining the protective factors associated with life satisfaction among Spanish speaking older adults in Costa Rica and in Spain. It identifies specific protective factors (spirituality/purpose in life, social support, and self-care) associated with the values and preferences held by participants in the study.


===MeSH Terms===
|keywords=* Muscle wasting
-
* aging
* anabolic resistance
* inflammation
* resistance training
* sarcopenia
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa309
}}
{{medline-entry
|title=Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33197687


===Keywords===
behavioral adaptations; life satisfaction; successful aging


==Improving trainee engagement in science: Lessons from a virtual seminar series.==
|keywords=* Angiopoietin-like protein (ANGPTL) 2
===Abstract===
* Cardio-ankle vascular index (CAVI)
To be a successful researcher, you are expected to have important skills beyond the bench such as being able to ask questions, talk about science with your peers, and organize scientific events. However, there is frequently little to no training or emphasis on these skills at the student and postdoc level. The virtual Aging Science Talks seminar series and Slack group have benefitted the scientific community in many ways amidst the chaos of coronavirus quarantines and lab shutdowns, but as a 2  year PhD student, I was particularly excited about how this format was able to engage trainees. We should end the era of trainees sitting at the back of the room while PIs dominate discussions and Q&A sessions with speakers. Reflecting on the advantages of Aging Science Talks can show us how to make future scientific events more engaging and inclusive for everyone.
* Chronic inflammation
* Hemodialysis
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2020.10.890
}}
{{medline-entry
|title=Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117418


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Aging science talks; Remote work; Students; Trainees
* Cardiovascular prevention
* Exercise-based cardiac rehabilitation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568038
}}
{{medline-entry
|title=rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103060


==A guide for medical practitioners transitioning to an encore career or retirement.==
===Abstract===
---


===MeSH Terms===
|keywords=* COVID-19
-
* False negative reactions
* Geriatrics
* Mass screening
* Reverse transcriptase polymerase chain reaction
* SARS-CoV-2
* Tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567648
}}
{{medline-entry
|title=The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080140


===Keywords===
Aging; Clinical competence


==Structural complexity is negatively associated with brain activity: a novel multimodal test of compensation theories of aging.==
|keywords=* aging
===Abstract===
* growth differentiation factor 15
Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atrophy causes a compensatory neural response in the form of increased brain activity in the prefrontal cortex to maintain cognition. Brain structural and functional data were collected from 63 middle-aged and older adults and 18 young-adult controls. Two distinct patterns of FD were found that separated cortical from subcortical structures. Subcortical FD was more strongly negatively correlated with age than cortical FD, and cortical FD was negatively associated with brain activity during memory retrieval in medial and lateral parietal cortices uniquely in middle-aged and older adults. Multivariate analyses revealed that the lower FD/higher brain activity pattern was associated with poorer cognition-patterns not present in young adults, consistent with compensation. Bayesian analyses provide further evidence against the modal interpretation of the atrophy-compensation hypothesis in the prefrontal cortex-a key principle found in some neurocognitive theories of aging.
* idiopathic pulmonary fibrosis
* interstitial lung abnormalities
* mortality
|full-text-url=https://sci-hub.do/10.1164/rccm.202007-2993OC
}}
{{medline-entry
|title=A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067129


===MeSH Terms===
-


===Keywords===
|keywords=* Functional food
Aging; Compensation; Default mode network; Episodic memory; Fractal dimensionality; fMRI
* aging
* beta-hydroxy beta-methylbutyrate
* muscle strength
* sarcopenia
* vitamin D
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.08.035
}}
{{medline-entry
|title=Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33021628


==Assessing the Effect of Training on the Cognition and Brain of Older Adults: Protocol for a Three-Arm Randomized Double-Blind Controlled Trial (ACTOP).==
===Abstract===
To prevent age-related cognitive impairment, many intervention programs offer exercises targeting different central cognitive processes. However, the effects of different process-based training programs are rarely compared within equivalent experimental designs. Using a randomized double-blind controlled trial, this project aims to examine and compare the impact of 2 process-based interventions, inhibition and updating, on the cognition and brain of older adults. A total of 90 healthy older adults were randomly assigned to 1 of 3 training conditions: (1) inhibition (Stroop-like exercises), (2) updating (N-back-type exercises), and (3) control active (quiz game exercise). Training was provided in 12 half-hour sessions over 4 weeks. First, the performance gain observed will be measured on the trained tasks. We will then determine the extent of transfer of gain on (1) untrained tasks that rely on the same cognitive process, (2) complex working memory (WM) measurements hypothesized to involve 1 of the 2 trained processes, and (3) virtual reality tasks that were designed to mimic real-life situations that require WM. We will assess whether training increases cortical volume given that the volume of the cortex is determined by cortical area and thickness in regions known to be involved in WM or changes task-related brain activation patterns measured with functional magnetic resonance imaging. Dose effects will be examined by measuring outcomes at different time points during training. We will also determine whether individual characteristics moderate the effect of training on cognitive and cerebral outcomes. Finally, we will evaluate whether training reduces the age-related deficit on transfer and brain outcomes, by comparing study participants to a group of 30 younger adults. The project was funded in January 2017; enrollment began in October 2017 and data collection was completed in April 2019. Data analysis has begun in June 2020 and the first results should be published by the end of 2020 or early 2021. The results of this study will help understand the relative efficacy of 2 attentional control interventions on the cognition and the brain of older adults, as well as the moderating role of individual characteristics on training efficiency and transfer. ClinicalTrials.gov NCT03532113; https://clinicaltrials.gov/ct2/show/NCT03532113. DERR1-10.2196/20430.


===MeSH Terms===
|keywords=* Aging
-
* Microbial co-occurrences
* Mucosal microbiome
* Systemic inflammation
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa256
}}
{{medline-entry
|title=The relationship between frailty and serum alpha klotho levels in geriatric patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32905907


===Keywords===
aging; brain plasticity; cognitive reserve; cognitive training; working memory


==Interactions of iron-based nanoparticles with soil dissolved organic matter: adsorption, aging, and effects on hexavalent chromium removal.==
|keywords=* Aging
===Abstract===
* Biomarkers
The interactions and mechanisms between soil dissolved organic matter (DOM) and three types of iron-based nanoparticles (NPs), i.e., nanoscale zero-valent iron (nZVI) particles, Fe O  NPs, and Fe O  NPs, were investigated in short-term exposure experiments. The adsorption results showed that soil DOM was rapidly adsorbed on the surface of the iron-based NPs with the adsorption rate varying according to Fe O  > Fe O  > nZVI. Spectral analysis results revealed that aromatic DOM fractions with high-molecular-weights were preferentially adsorbed. The binding mechanism was determined as hydrogen bonding and ligand exchange via Fourier transform infrared spectroscopy (FT-IR) analysis. Scanning electron microscopy, FT-IR, X-ray photoelectron spectroscopy, and X-ray diffraction were used to identify the corrosion products of the three iron-based NPs at the adsorption equilibrium. The results suggest that Fe O  and/or γ-Fe O  and α-FeOOH were the main corrosion products of nZVIs and α-FeOOH was obtained as an aged product of Fe O  NPs. Results of Cr(VI) removal tests suggest that the aged nZVI achieved 79.87% of Cr(VI) removal and the Cr(VI) removal efficiency was significantly improved by coating DOM onto Fe O  NPs. The overall data indicate the fate and transformation of iron-based NPs and the enhancement for Cr(VI) removal after interactions between DOM and NPs.
* Frailty syndrome
* Geriatric syndrome
* Sarcopenia
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104225
}}
{{medline-entry
|title=ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32872320


===MeSH Terms===
-


===Keywords===
|keywords=* ZMPSTE24
Adsorption; Aging products; Binding mechanism; Iron-based NPs; Soil DOM
* aging
* inflammation
* lamin A/C
* progerin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563344
}}
{{medline-entry
|title=Cultural and life style practices associated with low inflammatory physiology in Japanese adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32805392


==Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.==
===Abstract===
Sestrin2 (Sesn2) is involved in the maintenance of metabolic homeostasis and aging via modulation of the 5' AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) pathway. Wild-type and Sesn2 knockout (KO) mice of the 129/SvJ background were maintained in a pathogen-free authorized facility under a 12-hour dark/light cycle at 20°C-22°C and 50%-60% humidity. Mouse embryonic fibroblasts (MEFs) were prepared from 13.5-day-old embryos derived from Sesn2-KO mice mated with each other. The MEFs from Sesn2-KO mice showed enlarged and flattened morphologies and senescence-associated β-galactosidase activity, accompanied by an elevated level of reactive oxygen species. These senescence phenotypes recovered following treatment with N-acetyl-cysteine. Notably, the mRNA levels of NADPH oxidase 4 (NOX4) and transforming growth factor (TGF)-β were markedly increased in Sesn2-KO MEFs. Treatment of Sesn2-KO MEFs with the NOX inhibitor diphenyleneiodonium and the TGF-β inhibitor SB431542 restored cell growth inhibited by Sesn2-KO. Sesn2 attenuates cellular senescence via suppression of TGF-β- and NOX4-induced reactive oxygen species generation and subsequent inhibition of AMPK.


===MeSH Terms===
|keywords=* Aging
-
* Bathing
* C-reactive protein
* Diet
* Inflammation
* Interleukin-6
* Japan
* Tea
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544652
}}
{{medline-entry
|title=Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32467712


===Keywords===
NOX4; Reactive oxygen species; Senescence; Sestrin2


==Geometrical model for calculating the effect of surface morphology on total x-ray output of medical x-ray tubes.==
|keywords=* Aging
===Abstract===
* Breg cells
Correlation of characteristic surface appearance and surface roughness with measured air kerma (kinetic energy released in air) reduction of WRe stationary anode surfaces. A stationary anode test system was developed and used to alter nine initially ground sample surfaces through thermal cycling at high temperatures. A geometrical model based on high resolution surface data was implemented to correlate the measured reduction of the air kerma rate with the changing surface appearance of the samples. In addition to the nine thermally cycled samples, three samples received synthetic surface structuring to prove the applicability of the model to non-conventional surface alterations. Representative surface data and surface roughness values were acquired by laser scanning confocal microscopy. After thermal cycling in the stationary anode test system, the samples showed surface features comparable to rotating anodes after long-time operation. The established model enables the appearance of characteristic surface features like crack networks, pitting and local melting to be linked to the local x-ray output at 100 kV tube voltage, 10° anode take off angle and 2 mm of added Al filtration. The results from the conducted air kerma measurements were compared to the predicted total x-ray output reduction from the geometrical model and show, on average, less than 10 % error within the 12 tested samples. In certain boundaries, the calculated surface roughness R  showed a linear correlation with the measured air kerma reduction when samples were having comparable damaging characteristics and similar operation parameters. The orientation of the surface features had a strong impact on the measured air kerma rate which was shown by testing synthetically structured surfaces. The geometrical model used herein considers and describes the effect of individual surface features on the x-ray output. In close boundaries arithmetic surface roughness R  was found to be a useful characteristic value on estimating the effect of surface damage on total x-ray output.
* Exercise
* IL-10
* Rheumatoid arthritis
* T cells
* Treg cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229606
}}
{{medline-entry
|title=PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32438247


===MeSH Terms===
-


===Keywords===
|keywords=* Accelerated aging
Surface damage; laser scanning confocal microscopy; rotating anode; surface roughening; tube aging; tungsten; x-ray tube
* Inflammation
* Klotho
* Methylation
* PTSD
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293549
}}
{{medline-entry
|title=Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32283288


==Hypoperfusion is a potential inducer of immunosuppressive network in Alzheimer's disease.==
===Abstract===
Alzheimer's disease (AD) is a progressive neurodegenerative disease which causes a non-reversible cognitive impairment and dementia. The primary cause of late-onset AD remains unknown although its pathology was discovered over a century ago. Recently, the vascular hypothesis of AD has received backing from evidence emerging from neuroimaging studies which have revealed the presence of a significant hypoperfusion in the brain regions vulnerable to AD pathology. In fact, hypoxia can explain many of the pathological changes evident in AD pathology, e.g. the deposition of β-amyloid plaques and chronic low-grade inflammation. Hypoxia-inducible factor-1α (HIF-1α) stimulates inflammatory responses and modulates both innate and adaptive immunity. It is known that hypoxia-induced inflammation evokes compensatory anti-inflammatory response involving tissue-resident microglia/macrophages and infiltrated immune cells. Hypoxia/HIF-1α induce immunosuppression by (i) increasing the expression of immunosuppressive genes, (ii) stimulating adenosinergic signaling, (iii) enhancing aerobic glycolysis, i.e. lactate production, and (iv) augmenting the secretion of immunosuppressive exosomes. Interestingly, it seems that these common mechanisms are also involved in the pathogenesis of AD. In AD pathology, an enhanced immunosuppression appears, e.g. as a shift in microglia/macrophage phenotypes towards the anti-inflammatory M2 phenotype and an increase in the numbers of regulatory T cells (Treg). The augmented anti-inflammatory capacity promotes the resolution of acute inflammation but persistent inflammation has crucial effects not only on immune cells but also harmful responses to the homeostasis of AD brain. I will examine in detail the mechanisms of the hypoperfusion/hypoxia-induced immunosuppressive state in general and especially, in its association with AD pathogenesis. These immunological observations support the vascular hypothesis of AD pathology.


===MeSH Terms===
|keywords=* Aging
-
* Bereavement
* C-reactive protein
* Health
* Inflammation
* Widowhood
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415735
}}
{{medline-entry
|title=The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249368


===Keywords===
Ageing; Cerebral blood flow; Immunometabolism; Immunosenescence; MDSC; Neurovascular unit


==Numeracy Skills, Cognitive Reserve, and Psychological Well-Being: What Relationship in Late Adult Lifespan?==
|keywords=* Aging
===Abstract===
* Bariatric surgery
The capacity of understanding and manipulating numerical stimuli (i.e., numeracy) can impact decision making. This investigation was conducted to examine whether number comprehension and mental calculation predict hedonic (i.e., Scale of Positive and Negative Experience, SPANE) and eudaimonic (i.e., Flourishing Scale) well-being in late adulthood, and whether cognitive reserve (i.e., education, time spent for gardening, and time spent for leisure activities) and non-verbal reasoning predict numeracy skills of old adults. Additionally, the effect of age on numeracy was examined, controlling for the effect of education and cognitive efficiency. One hundred and fifty-eight (i.e., 65-94 years old) community-dwellers completed a battery of tools assessing numeracy, cognitive and metacognitive efficiency, and psychological well-being. Number comprehension, metacognition, time spent for leisure, and perceived physical health accounted for 23% of the variance in the SPANE condition, whereas metacognition, perceived physical health, time for leisure, and education explained 15% of the variance in the Flourishing condition. Moreover, cognitive reserve assessed in terms of vocabulary and education predicted mental calculation. Finally, aging significantly impacted the mental calculation performance of older participants. These findings suggest that numeracy skills can selectively impact the mental health and daily life of older adults.
* Elderly
* Obesity
* Sarcopenia
|full-text-url=https://sci-hub.do/10.1007/s11695-019-04198-4
}}
{{medline-entry
|title=Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32148813


===MeSH Terms===
-


===Keywords===
|keywords=* CRP
aging; cognitive reserve; mental calculation; mental health; metacognition; number comprehension; numeracy; physical health; psychological well-being
* advanced glycationed end products
* aging
* dAGE
* immunity
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020308
}}
{{medline-entry
|title=Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132919


==Eczema in elderly people.==
===Abstract===
Eczema is one of the most common reasons for consultation in older people. Many differential diagnoses must be eliminated, including scabies, bullous pemphigoid, and mycosis fungoides. Contact dermatitis may also be considered and the chemical(s) in question may vary according to the comorbidities involved, in particular, depending on whether or not the patient has a leg ulcer. Drug-induced eczematous eruptions can occur in elderly people, mainly with antihypertensive drugs (calcium inhibitors, diuretics, etc.). Recently, de novo atopic dermatitis has been described in elderly subjects, and the role of pollution has been evoked for these eczemas. Management of eczema in the elderly is challenging, and emollients and dermocorticosteroids are helpful. However, local corticosteroids may have some adverse effects in this vulnerable population, such as skin atrophy, diabetes and hypertension. Phototherapy, when possible, and low-dose methotrexate in particular may be interesting treatment options.


===MeSH Terms===
|keywords=* Stroop task
-
* aging
* bimanual coordination
* inhibition
* mediation analysis
* switching
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041435
}}
{{medline-entry
|title=Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125944


===Keywords===
atopic dermatitis; drug hypersensitivity; eczema; elderly; skin aging


==Building and Sustaining a Community Advisory Board of African American Older Adults as the Foundation for Volunteer Research Recruitment and Retention in Health Sciences.==
|keywords=* aging
===Abstract===
* post-traumatic chronic osteomyelitis
Older African Americans' participation in health-related research is severely limited; they are not involved in sufficient numbers to ensure the applicability of advancements in medical and behavioral health. This research participation gap exacerbates older African Americans' vulnerability to poor health outcomes and disparities. The Michigan Center for Urban African American Aging Research employs a progressive community-based participatory model that utilizes a structured community advisory board (CAB) of African American older adults in metro Detroit, Michigan to oversee the research recruitment and retention of fellow minority older adult research participants. CAB members develop and support community health programming that provides free resources to older adults and also serves as fertile ground for recruiting participants in a volunteer research registry. CAB members are also provided ongoing training on social and behavioral health research and are supported in acting as a consultancy to outside researchers where they can be compensated for their expertise and engagement. This community-engaged model of sustaining a CAB of African American older adults offers key lessons learned on building relationships and trust, valuing and leveraging community members' expertise and time, sharing decision-making, and fostering genuine community all while promoting research recruitment and retention among underserved populations.
* telomere
|full-text-url=https://sci-hub.do/10.1089/sur.2019.326
}}
{{medline-entry
|title=Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31886815


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Aging
* Disease Progression
* Female
* Frail Elderly
* Frailty
* Geriatric Assessment
* Humans
* Independent Living
* Longitudinal Studies
* Male
* Nutrition Assessment
* Nutritional Status
* Physical Examination
* Risk Factors
* Singapore
* Socioeconomic Factors
|keywords=* Frailty
* longitudinal
* risk factors
* transition
|full-text-url=https://sci-hub.do/10.1007/s12603-019-1277-8
}}
{{medline-entry
|title=Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781724


===Keywords===
|mesh-terms=* Aged
African American; Aging; Community-based Participatory Approach; Research Recruitment
* Aging
* Cardiovascular Diseases
* Female
* Humans
* Inflammation
* Male
* Muscle Strength
* Obesity
* Physical Exertion
|keywords=* Inflammation
* cardiovascular disease risk factors
* obesity
* physical activity
* physical function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996491
}}
{{medline-entry
|title=Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31748308


==Low Self-Perception of Malnutrition in Older Hospitalized Patients.==
|mesh-terms=* Adult
===Abstract===
* Aged
Studies focusing on self-perception of nutritional status in older hospitalized patients are lacking. We aimed to examine the self-perception of body weight and nutritional status among older hospitalized patients compared to their actual body weight and nutritional status based on medical assessment. This observational cross-sectional study investigated 197 older participants (mean age 82.2±6.8 years, 61% women) who were consecutively admitted to the geriatric acute care ward. Body weight status and nutritional status were assessed using WHO-BMI classification and Mini Nutritional Assessment-Short Form (MNA-SF), respectively. Self-perceived body weight status and nutritional status were assessed with a standardized questionnaire. A follow-up was performed with a short telephone interview after three months. According to MNA-SF, 49% and 35% were at risk of malnutrition and malnourished, respectively. There was no agreement between self-perceived nutritional status and objective nutritional status according to MNA-SF (Kappa: 0.06). A slight agreement was found between subjective body weight status and objective body weight status according to WHO-BMI classification (Kappa: 0.19). A total of 184 patients completed the 3 months follow-up and additional 9 patients died during this time, of which 7 and 2 were malnourished and at risk of malnutrition according to MNA-SF, respectively. Of those who were malnourished and at risk of malnutrition based on MNA-SF and died during follow-up, 67.7% did not realize their malnutrition. Compared to the patients with normal nutritional status during hospitalization, malnourished patients based on MNA-SF had higher rates of unplanned hospital readmission and further weight loss and more often reported health deterioration and experienced death within three months after discharge. No agreement between self-perceived nutritional status and objective nutritional status among older hospitalized patients was found. Our study highlights the need to raise knowledge about the issue of malnutrition and increase awareness of health risks associated with malnutrition among older hospitalized patients.
* Aged, 80 and over
* Female
* Fever of Unknown Origin
* Humans
* Japan
* Male
* Middle Aged
* Prospective Studies
* Young Adult
|keywords=* Japan
* aging population
* elderly
* erythrocyte sedimentation rate
* fever of unknown origin
* prospective studies
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886908
}}
{{medline-entry
|title=Decrease in Serum Vitamin D Level of Older Patients with Fatigue.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31635199


===MeSH Terms===
|mesh-terms=* Aged
-
* Cohort Studies
* Fatigue
* Female
* Humans
* Male
* Middle Aged
* Vitamin D
* Vitamin D Deficiency
|keywords=* aging
* mental fatigue
* older
* physical fatigue
* sex differences
* vitamin D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836014
}}
{{medline-entry
|title=The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31533354


===Keywords===
|mesh-terms=* Aged
body weight; geriatrics; malnutrition; older patients; self-perception
* Aged, 80 and over
* Biomarkers
* C-Reactive Protein
* CD4-CD8 Ratio
* Cross-Sectional Studies
* Female
* Frail Elderly
* Frailty
* Humans
* Independent Living
* Interleukin-6
* Male
* Middle Aged
* Thailand
|keywords=* C-reactive protein
* Thailand
* aging
* cross-sectional study
* frailty
* frailty biomarkers
* fried’s phenotypes
* interleukin-6
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765843
}}
{{medline-entry
|title=Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493520


==Breed-related expression patterns of Ki67, γH2AX, and p21 during ageing in the canine liver.==
|mesh-terms=* Activities of Daily Living
===Abstract===
* Aged
Cellular senescence is a molecular hallmark of ageing that is associated with multiple pathologies, and DNA damage marker γH2AX, together with cell cycle inhibitor p21, have been used as senescence markers in multiple species including dogs. Idiopathic canine chronic hepatitis has recognised breed-related differences in predisposition and prognosis, but reasons behind this are poorly understood. This retrospective study using archived post mortem tissue aimed to provide insight into liver ageing in 51 microscopically normal canine livers across seven breed categories, including those with and without increased risk of chronic hepatitis. Immunohistochemistry was conducted for γH2AX, p21, and cell proliferation marker Ki67, and the mean number of positive hepatocytes per high power field was determined. All three markers were strongly correlated to each other, but no age-dependent expression was seen in the combined study population. Overall expression levels were low in most dogs, with median values representing less than 1.5% of hepatocytes, but this increased to 20-30% in individual dogs at the upper end of the range. Individual breed differences were noted in two breeds that have increased risk of chronic hepatitis, with English Springer Spaniels having lower expression of Ki67 than other dogs, and Labradors having higher expression of Ki67 and γH2AX than other dogs. These results warrant further investigation in these breeds and highlight a need to validate reliable markers of cellular senescence in dogs.
* Biomarkers
* Body Mass Index
* C-Reactive Protein
* Cognitive Dysfunction
* Depression
* Female
* Follow-Up Studies
* Geriatric Assessment
* Hand Strength
* Homocysteine
* Humans
* Independent Living
* Inflammation
* Male
* Mobility Limitation
* Neuropsychological Tests
* Prospective Studies
* Risk Factors
* Time Factors
|keywords=* Aging
* C-reactive protein
* Homocysteine
* Inflammation
* Intrinsic capacity
* Older adults
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110716
}}
{{medline-entry
|title=Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494341


===MeSH Terms===
|mesh-terms=* Age Factors
-
* Aged
* Aged, 80 and over
* Aging
* C-Reactive Protein
* England
* Female
* Ferritins
* Fibrinogen
* Humans
* Inflammation
* Loneliness
* Longitudinal Studies
* Male
* Middle Aged
|keywords=* C-reactive protein
* Ferritin
* Fibrinogen
* Inflammation
* Loneliness
|full-text-url=https://sci-hub.do/10.1016/j.psyneuen.2019.104421
}}
{{medline-entry
|title=The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31471891


===Keywords===
|mesh-terms=* Aged
Ageing; Canine; Ki67; Liver; Senescence
* Aged, 80 and over
* Echocardiography
* Female
* Humans
* Hydrocortisone
* Inflammation
* Male
* Metabolic Syndrome
|keywords=* Aging
* Cortisol
* Inflammation
* Metabolic syndrome
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01322-3
}}
{{medline-entry
|title=Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31426866


==Volunteer service and positive attitudes toward aging among Chinese older adults: The mediating role of health.==
|mesh-terms=* Adult
===Abstract===
* Biomarkers
Attitude toward aging is an important indicator for measuring the wellbeing of older people, and a vital part of active and healthy aging. We aimed to assess the relationship between volunteer service and attitudes toward aging held by older people and to determine the mediating role of health. We analyzed the data of 10,792 Chinese people over age 60 from the 2014 Chinese Longitudinal Aging Social Survey. We used multiple linear regression models and the two-stage least-squares model to explore the correlation between volunteer service and attitudes toward aging. Furthermore, we applied structural equation modeling to test for mediation effects of different aspects of health. We found that volunteer service was significantly associated with attitudes toward aging (β = 0.335, p < 0.001), while self-assessed health, physical health, and mental health played a mediating role between volunteer service and attitudes toward aging held by older adults. In exploring ways to cope with the challenges brought about by the aging of the population, we found that participating in volunteer services not only improves older people's self-assessed physical, and mental health, but also improves their positive attitudes toward aging. Therefore, under the framework of active and healthy aging, volunteer service and participation in social activities can enhance social vitality and welfare, reduce social burden, and improve quality of life.
* Blood Pressure
* C-Reactive Protein
* Cardiovascular Diseases
* Circadian Rhythm
* Diet
* Energy Intake
* Fasting
* Heart Rate
* Humans
* Inflammation
* Male
* Metabolic Diseases
* Middle Aged
* Nutritional Physiological Phenomena
* Regression Analysis
* Risk Factors
* Young Adult
|keywords=* Aging
* Health benefits
* Inflammation
* Recurrent fasting
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700786
}}
{{medline-entry
|title=Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31393198


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Antirheumatic Agents
* Arthritis, Rheumatoid
* Arthroplasty, Replacement
* Arthroplasty, Replacement, Knee
* Biological Products
* Drug Utilization
* Female
* Humans
* Japan
* Male
* Middle Aged
* Postoperative Complications
|keywords=* C-reactive protein
* Rheumatoid arthritis
* aging
* arthroplasty
* drug therapy
|full-text-url=https://sci-hub.do/10.1080/14397595.2019.1649111
}}
==CS==


===Keywords===
{{medline-entry
Attitude toward aging; Chinese; Mental health; Older people; Physical health; Self-assessed health; Volunteer service
|title=Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198514


==Functional Connectivity of Successful Picture-Naming: Age-Specific Organization and the Effect of Engaging in Stimulating Activities.==
===Abstract===
Aging is a lifelong process that starts at birth. Throughout the course of their life, individuals are exposed to various levels of stimulating activities. A higher level of engagement in such activities is suspected to protect against the normal course of cognitive aging or the cognitive manifestations of age-related brain diseases. However, the exact mechanism underlying such protective action remains unclear. The concept of the neurocognitive reserve was introduced to refer to the hypothesis that engagement in stimulating activities shapes brain structure and function, thus indirectly allowing for better preserved cognitive abilities. Although it is known that word production is among the best-preserved cognitive abilities in aging, the underlying neurofunctional mechanisms that allow this relative preservation are still unknown, and it is still unclear how engagement in stimulating activities affects these processes. The objective of this study is to describe the brain functional connectivity patterns associated with picture-naming abilities in younger and older adults with varying levels of engagement in stimulating activities, as a proxy for neurocognitive reserve. A mediation analysis was applied to determine whether the association between reserve proxies and naming accuracy is dependent on task FC. Results show that naming accuracy depends on the posterior cingulate cortex (PCC) functional decoupling in both younger and older adults but through different pathways. While high-performing older adults rely on the asynchronization of this area from motor speech regions' activity, the best-performing younger adults rely on the functional decoupling with language-related regions. Mediation analysis reveals that the PCC decoupling mediates the relationship between the level of engagement in stimulating activities and naming accuracy in younger adults, but not in older adults. These findings suggest that reserve-related mechanisms may be more critical for naming in early adult life, while older adults' neurofunctional organization may benefit more from a lifetime of acquired knowledge.


===MeSH Terms===
|keywords=* Exercise
-
* aging
* hypertension
* hypotension
* resistance training
|full-text-url=https://sci-hub.do/10.1080/10641963.2020.1847130
}}
{{medline-entry
|title=Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33207435


===Keywords===
aging; cognitive reserve; functional connectivity; mediation analysis; picture-naming


==Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.==
|keywords=* Condensation sink
===Abstract===
* Haze
Sirtuins are class III histone deacetylase (HDAC) enzymes that target both histone and non-histone substrates. They are linked to different brain functions and the regulation of different isoforms of these enzymes is touted to be an emerging therapy for the treatment of neurodegenerative diseases (NDs), including Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). The level of sirtuins affects brain health as many sirtuin-regulated pathways are responsible for the progression of NDs. Certain sirtuins are also implicated in aging, which is a risk factor for many NDs. In addition to SIRT1-3, it has been suggested that the less studied sirtuins (SIRT4-7) also play critical roles in brain health. This review delineates the role of each sirtuin isoform in NDs from a disease centric perspective and provides an up-to-date overview of sirtuin modulators and their potential use as therapeutics in these diseases. Furthermore, the future perspectives for sirtuin modulator development and their therapeutic application in neurodegeneration are outlined in detail, hence providing a research direction for future studies.
* New particle formation
* Photochemical aging
* Pollution evolution
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.142207
}}
{{medline-entry
|title=Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143976


===MeSH Terms===
-


===Keywords===
|keywords=* Accelerated aging
Aging; neurodegenerative diseases; neuroprotective; sirtuin; sirtuin activators; sirtuin inhibitors
* Biochar
* Cadmium
* Enzyme activity
* Heavy metal stabilization
* Soil remediation
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.115846
}}
{{medline-entry
|title=Cockayne syndrome proteins [[CS]]A and [[CS]]B maintain mitochondrial homeostasis through NAD  signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166073


==Short communication: Evidence for the 'rate-of-living' hypothesis between mammals and lizards not in birds, with field metabolic rate.==
===Abstract===
Longevity, an important life-history trait, is determined by extrinsic, intrinsic, or both factors causing mortality. Here, we used body mass (BM), field metabolic rate (FMR), longevity, and female maturity data reported from 300 amniote species to test whether 1) longevity was related to BM, FMR and female maturity, and 2) FMR, female maturity, or both, had a direct effect on longevity and whether an indirect effect of FMR on female maturity improved model fit. The results showed that BM was positively related to longevity and FMR, but negatively related to mass-specific FMR (mFMR) in amniotes. In the best model, phylogenetic path analysis showed that longevity had a direct negatively correlation with mFMR in lizards, and longevity had an indirect negatively correlation with mFMR through female maturity in mammals. However, longevity had a direct positively correlation with mFMR in birds. Furthermore, longevity had a positive correlation associating longevity with female maturity in endotherms (birds and mammals) but only a weak correlation with female maturity in ectotherms (lizards). Our results supported the life-history theory and the 'rate-of-living' hypothesis in lizards and mammals but did not support them in birds.


===MeSH Terms===
|keywords=* AMPK
-
* Cockayne syndrome
* NAD+
* accelerated ageing
* aging
* mitochondrial maintenance
* mitophagy
|full-text-url=https://sci-hub.do/10.1111/acel.13268
}}
{{medline-entry
|title=Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32710546


===Keywords===
Amniote; Field metabolic rate; Life history; Longevity


==Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.==
|keywords=* Cognition
===Abstract===
* Cognitive Aging
Frailty is a geriatric syndrome represented by susceptibility to precipitating health events and reduced functional reserve. Frailty can be difficult to measure in clinical practice and research. One approach to approximate frailty is based on a deficit accumulation approach, which assesses a larger number of less specific measures such as the presence of comorbidities, physical or cognitive assessments, and lab tests, and summarizes these as a frailty index. The objective of this study was to develop such an index using the Lifestyle Interventions and Independence for Elders (LIFE) Study and evaluate the validity of the frailty measure derived based on baseline information via its association with the primary outcomes of the trial, namely major mobility disability (MMD) and persistent MMD (pMMD). Further, this study aimed to evaluate the effectiveness of the physical activity intervention among participants based on their baseline frailty score. Subjects in the LIFE Study were evaluated at baseline for demographics, clinical history, and a battery of physical and cognitive functioning assessments. In total, 75 possible deficits were scored either as present (yes/no) or based on each score's quintiles for score-based assessments. The frailty index was measured as the total sum of deficits divided by the total number of possible deficits on a continuous scale between 0 and 100 (i.e., percent of deficits present). The frailty index was further divided into quintiles for comparison. A proportional hazards model was estimated for the MMD outcome controlling for other baseline information. A data driven approach was also used to determine relevant cut-offs in the frailty index where the trial intervention appeared to be modified. Among 1635 trial participants, the mean frailty index was 30.4 ± 6.6 and normally distributed. Over 2.5 years of average follow-up, 14.6%, 16.5%, 18.6%, 22.6%, and 27.6% of participants experienced MMD in quintiles 1-5, respectively. Each 1-unit increase in the frailty index increased the hazard of MMD by 4% (2-5%), and there was a nearly 2-fold increase in MMD between the highest and lowest frailty quintiles. Using log-rank criteria, a cut-point at the median was identified. Further, iterations tested for a frailty cut-off and indicated a subgroup beyond the 85th percentile wherein the physical activity intervention appeared to be no longer be effective. This internally derived deficit accumulation frailty index was uniquely able to identify individuals at higher risk of MMD and pMMD and showed that along the spectrum of frailty, the physical activity intervention remained effective for the majority of participants.
* Sensory
* Vision loss
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa184
}}
{{medline-entry
|title=Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32700098


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
LIFE Study; deficit accumulation; disability; frailty; healthy aging; mobility; older adults
* Functionality
* Instability resistance training
* Muscle hypertrophy
* TRX training
|full-text-url=https://sci-hub.do/10.1007/s00421-020-04446-x
}}
{{medline-entry
|title=Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693658


==Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.==
===Abstract===
Intron retention (IR) is the least well-understood alternative splicing type in animals, and its prevalence and function in physiological and pathological processes have long been underestimated. Cellular senescence contributes to individual aging and age-related diseases and can also serve as an important cancer prevention mechanism. Dynamic IR events have been observed in senescence models and aged tissues; however, whether and how IR impacts senescence remain unclear. Through analyzing polyA  RNA-seq data from human replicative senescence models, we found IR was prevalent and dynamically regulated during senescence and IR changes negatively correlated with expression alteration of corresponding genes. We discovered that knocking down (KD) splicing factor U2AF1, which showed higher binding density to retained introns and decreased expression during senescence, led to senescence-associated phenotypes and global IR changes. Intriguingly, U2AF1-KD-induced IR changes also negatively correlated with gene expression. Furthermore, we demonstrated that U2AF1-mediated IR of specific gene (CPNE1 as an example) contributed to cellular senescence. Decreased expression of U2AF1, higher IR of CPNE1, and reduced expression of CPNE1 were also discovered in dermal fibroblasts with age. We discovered prevalent IR could fine-tune gene expression and contribute to senescence-associated phenotypes, largely extending the biological significance of IR.


===MeSH Terms===
|keywords=* Aging
-
* Birth Cohort Effect
* Contrast Sensitivity
* Epidemiology
* Visual Function
|full-text-url=https://sci-hub.do/10.1080/09286586.2020.1791909
}}
{{medline-entry
|title=Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32578072


===Keywords===
CPNE1; U2AF1; intron retention; senescence; splicing factor


==Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.==
|keywords=* Aging
===Abstract===
* Cold-sensitive
Aging results in a chronic, pro-inflammatory state which can promote and exacerbate age-associated diseases. In contrast, physical activity in older adults improves whole body health, protects against disease, and reduces inflammation, but the elderly are less active making it difficult to disentangle the effects of aging from a sedentary lifestyle. To interrogate this interaction, we analyzed peripheral blood collected at rest and post-exercise from 68 healthy younger and older donors that were either physically active aerobic exercisers or chronically sedentary. Subjects were profiled for 44 low-abundance cytokines, chemokines and growth factors in peripheral blood. At rest, we found that regular physical activity had no impact on the age-related elevation in circulating IL-18, eotaxin, GRO, IL-8, IP-10, PDGF-AA or RANTES. Similarly, there was no impact of physical activity on the age-related reduction in VEGF, EGF or IL-12 (p70). However, older exercisers had lower resting plasma fractalkine, IL-3, IL-6 and TNF-α compared to sedentary older adults. In contrast to our resting characterization, blood responses following acute exercise produced more striking difference between groups. Physically active younger and older subjects increased over 50% of the analyzed factors in their blood which resulted in both unique and overlapping exercise signatures. However, sedentary individuals, particularly the elderly, had few detectable changes in response to exercise. Overall, we show that long term physical activity has a limited effect on age-associated changes in basal cytokines and chemokines in the healthy elderly, yet physically active individuals exhibit a broader induction of factors post-exercise irrespective of age.
* DNA repair
* Gametogenesis
* Hydra oligactis
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394996
}}
{{medline-entry
|title=Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32317388


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Aging
* Attention
* Brain Waves
* Cortical Synchronization
* Humans
* Male
* Norepinephrine
* Reflex, Pupillary
|keywords=* cognitive aging
* locus coeruleus
* noradrenaline
* norepinephrine
* rhythmic neural activity
* selective attention
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252473
}}
{{medline-entry
|title=Cellular senescence: from anti-cancer weapon to anti-aging target.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32060861


===Keywords===
|mesh-terms=* Aging
growth factors; human aging; inflammation; physical activity
* Animals
* Antineoplastic Agents
* Breast Neoplasms
* Cell Proliferation
* Cell Transformation, Neoplastic
* Cellular Senescence
* Cyclin-Dependent Kinases
* Drug Discovery
* Female
* Humans
* Piperazines
* Protein Kinase Inhibitors
* Pyridines
|keywords=* cancer
* cellular senescence
* healthy aging
* pro-senescence cancer therapy
* senolytic therapies
|full-text-url=https://sci-hub.do/10.1007/s11427-019-1629-6
}}
{{medline-entry
|title=Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31857692


==Middle age as a turning point in mouse cerebral cortex energy and redox metabolism: Modulation by every-other-day fasting.==
|mesh-terms=* Aging
===Abstract===
* Animals
Normal brain aging is accompanied by intensification of free radical processes and compromised bioenergetics. Caloric restriction is expected to counteract these changes but the underlying protective mechanisms remain poorly understood. The present work aimed to investigate the intensity of oxidative stress and energy metabolism in the cerebral cortex comparing mice of different ages as well as comparing mice given one of two regimens of food availability: ad libitum versus every-other-day fasting (EODF). Levels of oxidative stress markers, ketone bodies, glycolytic intermediates, mitochondrial respiration, and activities of antioxidant and glycolytic enzymes were assessed in cortex from 6-, 12- and 18-month old C57BL/6 J mice. The greatest increase in oxidative stress markers and the sharpest decline in key glycolytic enzyme activities was observed in mice upon the transition from young (6 months) to middle (12 months) age, with smaller changes occurring upon transition to old-age (18 months). Brain mitochondrial respiration showed no significant changes with age. A decrease in the activities of key glycolytic enzymes was accompanied by an increase in the activity of glucose-6-phosphate dehydrogenase suggesting that during normal brain aging glucose metabolism is altered to lower glycolytic activity and increase dependence on the pentose-phosphate pathway. Interestingly, levels of ketone bodies and antioxidant capacity showed a greater decrease in the brain cortex of females as compared with males. The EODF regimen further suppressed glycolytic enzyme activities in the cortex of old mice, and partially enhanced oxygen consumption and respiratory control in the cortex of middle aged and old males. Thus, in the mammalian cortex the major aging-induced metabolic changes are already seen in middle age and are slightly alleviated by an intermittent fasting mode of feeding.
* Calcium Signaling
* Citrate (si)-Synthase
* Citric Acid Cycle
* Female
* Infertility, Male
* Male
* Metabolome
* Mice
* Ovum
* Spermatozoa


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096335
-
}}
{{medline-entry
|title=Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737341


===Keywords===
Aging; Antioxidant enzymes; Cerebral cortex; Glycolytic enzymes; Mitochondrial respiration; Pentose phosphate pathway


==Early brainstem [18F]THK5351 uptake is linked to cortical hyper-excitability in healthy aging.==
|keywords=* Airway inflammation
===Abstract===
* autophagy
Neuronal hyper-excitability characterizes the early stages of Alzheimer's disease (AD). In animals, early misfolded tau and amyloid-beta (Aβ) protein accumulation, both central to AD neuropathology, promote cortical excitability and neuronal network dysfunction. In healthy humans, misfolded tau and Aβ aggregates are first detected, respectively, in the brainstem and frontomedial and temporobasal cortices, decades prior to the onset of AD cognitive symptoms. Whether cortical excitability is related to early brainstem tau, and its associated neuroinflammation, and cortical Aβ aggregations remains unknown. We probed frontal cortex excitability, using transcranial magnetic stimulation combined with electroencephalography, in a sample of 64 healthy late middle-aged individuals (50-69 y; 45 women). We assessed whole-brain [18F]THK5351 positron emission tomography (PET) uptake as a proxy measure of tau/neuroinflammation, and whole-brain Aβ burden with [18F]Flutemetamol or [18F]Florbetapir radiotracers. We find that higher [18F]THK5351 uptake in a brainstem monoaminergic compartment is associated with increased cortical excitability (r = .29, p = .02). By contrast, [18F]THK5351 PET signal in the hippocampal formation, although strongly correlated with brainstem signal in whole-brain voxel-based quantification analyses (pFWE-corrected < .001), was not significantly associated with cortical excitability (r = .14, p = .25). Importantly, no significant association was found between early Aβ cortical deposits and cortical excitability (r = -.20, p = .11). These findings reveal potential brain substrates for increased cortical excitability in preclinical AD and may constitute functional in vivo correlates of early brainstem tau accumulation and neuroinflammation in humans. EudraCT 2016-001436-35. F.R.S.-FNRS Belgium, Wallonie-Bruxelles International, ULiège, Fondation Simone et Pierre Clerdent, European Regional Development Fund.
* cellular senescence
* chronic obstructive pulmonary disease (COPD)
* necroptosis
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831915
}}
{{medline-entry
|title=Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524179


===MeSH Terms===
|mesh-terms=* Aging
-
* Amyloidogenic Proteins
* Animals
* Biological Evolution
* Brain
* Female
* Humans
* Inheritance Patterns
* Models, Neurological
* Neurodegenerative Diseases
* Pregnancy
* Stress, Physiological
|keywords=* Alzheimer’s disease
* Parkinson’s disease
* amyloid cascade hypothesis
* amyloidogenic proteins
* antimicrobial protection model
* cross-seeding
* evolvability hypothesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839461
}}
{{medline-entry
|title=Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428695


===Keywords===
|mesh-terms=* Alveolar Epithelial Cells
Aging; Alzheimer's disease; Neuroimaging; Neuroscience
* Animals
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Cytokines
* Emphysema
* Insulin-Like Growth Factor I
* Lung
* Mice, Inbred C57BL
* Models, Biological
* Promoter Regions, Genetic
* Proto-Oncogene Proteins c-akt
* Pulmonary Disease, Chronic Obstructive
* RNA, Messenger
* Signal Transduction
* Smoking
|keywords=* Molecular biology
* Senescence
* Stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689060
}}
==CSF1R==


==Suicide and Suicide Attempts in the Elderly Patients: An Epidemiological Analysis of Risk Factors and Prevention.==
{{medline-entry
===Abstract===
|title=[[CSF1R]] inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.
Some elderly commit suicide due to the interaction of various factors including, for example, feelings of loneliness, financial distress, alcohol abuse, chronic pain, progressive diseases, and personality disorders. The data from the EU countries with the highest rates of suicide and suicide attempts among people over 55 years of age warrant the consideration of new approaches to address this social problem. PubMed and other databases including Polish National data were used for the analyses. The average European suicide-attempt rate is 18 per 100 thousand inhabitants. More cases of suicides were reported among those over 55 years of age. Suicide attempts from 2012 to 2014 and deaths in 2012 have been reviewed. The risk factors involved in these events such as, depression, social situation including loneliness, health condition, etc., have been discussed to suggest a plausible preventative approach for this important elderly problem. The psychophysiology of elderly persons affected by retirement, socio-economic changes, limited personal autonomy, loneliness, lack of support by the family, and diseases ultimately may lead elderly persons to commit suicide. Thus, financial freedom, family support (respect, love, and care), proper medications, psychological, and psychiatric interventions may help the elderly avoid suicidal thoughts and prevent attempts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32007953


===MeSH Terms===
-


===Keywords===
|keywords=* CSF1R
chronic pain; elderly; geriatrics; gerontology; life quality.; personality disorder; psyhcology; suicide and suicide attempt
* adipose
* aging
* environmental enrichment
* microglia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041757
}}
{{medline-entry
|title=Modulation of Microglia by Voluntary Exercise or [[CSF1R]] Inhibition Prevents Age-Related Loss of Functional Motor Units.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31693894


==Clinical outcomes in patients admitted to hospital with cervical spine fractures or with hip fractures.==
|mesh-terms=* Aging
===Abstract===
* Animals
Patients admitted with a cervical fracture are twice as likely to die within 30 days of injury than those with a hip fracture. However, guidelines for the management of cervical fractures are less available than for hip fractures. We hypothesise that outcomes may differ between these types of fractures. We analysed 1359 patients (406 men, 953 women) with mean age of 83.8 years (standard deviation = 8.7) admitted to a National Health Service hospital in 2013-2019 with a cervical (7.5%) or hip fracture (92.5%) of similar age. The association of cervical fracture (hip fracture as reference), hospital length of stay (LOS), co-morbidities, age and sex with outcomes (acute delirium, new pressure ulcer, and discharge to residential/nursing care) was assessed by stepwise multivariate logistic regression. Acute delirium without history of dementia was increased with cervical fractures: odds ratio (OR) = 2.4, 95% confidence interval (CI) = 1.3-4.7, age ≥ 80 years: OR = 3.5 (95% CI = 1.9-6.4), history of stroke: OR = 1.8 (95% CI = 1.0-3.1) and ischaemic heart disease: OR = 1.9 (95% CI = 1.1-3.6); pressure ulcers was increased with cervical fractures: OR = 10.9 (95% CI = 5.3-22.7), LOS of 2-3 weeks: OR = 3.0 (95% CI = 1.2-7.5) and LOS of ≥ 3 weeks: OR = 4.9, 95% CI = 2.2-11.0; and discharge to residential/nursing care was increased with cervical fractures: OR = 3.2 (95% CI = 1.4-7.0), LOS of ≥ 3 weeks: OR = 4.4 (95% CI = 2.5-7.6), dementia: OR = 2.7 (95% CI = 1.6-4.7), Parkinson's disease: OR = 3.4 (95% CI = 1.3-8.8), and age ≥ 80 years: OR = 2.7 (95% CI = 1.3-5.6). In conclusion, compared with hip fracture, cervical fracture is more likely to associate with acute delirium and pressure ulcers, and for discharge to residency of high level of care, independent of established risk factors.
* Cell Line
* Databases, Genetic
* Humans
* Induced Pluripotent Stem Cells
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* Microglia
* Motor Neurons
* Muscle, Skeletal
* Neuromuscular Junction
* Neuronal Plasticity
* Physical Conditioning, Animal
* RNA-Seq
* Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
* Spinal Cord
|keywords=* CSF1R inhibition
* aging
* exercise
* innervation
* microglia
* motor unit
* neuroinflammation
* neuromuscular junction
* neuromuscular system
* spinal cord
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.10.003
}}
==CTCF==


===MeSH Terms===
{{medline-entry
-
|title=New targeted approaches for epigenetic age predictions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32580727


===Keywords===
Discharge destination; Geriatrics; Length of stay; Mortality; Pressure ulcers


==Longevity record of arctic skua ([i]Stercorarius parasiticus[/i]).==
|keywords=* Aging
===Abstract===
* Amplicon sequencing
The arctic skua ([i]Stercorarius parasiticus[/i]) is one of the most long-lived bird species. In 2010, we captured in Finland an adult, female arctic skua which had been ringed as a nestling in 1987. We tagged it also with a color ring. The bird has last been seen in July 2020 at the age of 33 years, making it most likely the oldest known arctic skua of the world. In 2010-2011 the bird carried a light-level measuring geolocator, the data of which revealed that the bird had spent the nonbreeding season in the Canary Current area on the west coast of Africa. Breeding populations of arctic skuas have declined recently especially in British Isles, thus it is useful to get longevity data of this species with a high breeding site fidelity.
* Blood
* Buccal swabs
* CTCF
* DNA methylation
* Droplet digital PCR
* Epigenetic
* Human
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315536
}}
==CTH==


===MeSH Terms===
{{medline-entry
-
|title=Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31743999


===Keywords===
arctic skua; breeding; geolocator; longevity; migration; seabird


==A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.==
|keywords=* APOE
===Abstract===
* Aging
The knowledge about the age effects in speech acoustics is still disperse and incomplete. This study extends the analyses of the effects of age and gender on acoustics of European Portuguese (EP) oral vowels, in order to complement initial studies with limited sets of acoustic parameters, and to further investigate unclear or inconsistent results. A database of EP vowels produced by a group of 113 adults, aged between 35 and 97, was used. Duration, fundamental frequency (f0), formant frequencies (F1 to F3), and a selection of vowel space metrics (F1 and F2 range ratios, vowel articulation index [VAI] and formant centralization ratio [FCR]) were analyzed. To avoid the arguable division into age groups, the analyses considered age as a continuous variable. The most relevant age-related results included: vowel duration increase in both genders; a general tendency to formant frequencies decrease for females; changes that were consistent with vowel centralization for males, confirmed by the vowel space acoustic indexes; and no evidence of F3 decrease with age, in both genders. This study has contributed to knowledge on aging speech, providing new information for an additional language. The results corroborated that acoustic characteristics of speech change with age and present different patterns between genders.
* Alzheimer’s disease
* cerebral blood flow
* cognition
* cognitive decline
* grey matter
* magnetic resonance imaging
* tau proteins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310575
}}
==CTLA4==


===MeSH Terms===
{{medline-entry
-
|title=Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070170


===Keywords===
Acoustic; Aging voice; European Portuguese; Oral vowel


==Senescence and the SASP: many therapeutic avenues.==
|keywords=* CTLA-4
===Abstract===
* Geroscience
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay aging and limit dysfunction, known as "senotherapy," is gaining momentum. While drugs that selectively kill senescent cells, termed "senolytics" are a major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarize the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary or an alternative to current senolytic approaches.
* IL-6
* Immunosenescence
* Inflammaging
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa271
}}
==CTRL==


===MeSH Terms===
{{medline-entry
-
|title=Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32966120


===Keywords===
SASP; aging; cancer; disease; inflammation; senescence; senolytics; senomorphics; therapeutics


==Exercise and the Cisd2 Prolongevity Gene: Two Promising Strategies to Delay the Aging of Skeletal Muscle.==
|keywords=* aging
===Abstract===
* critical torque
Aging is an evolutionally conserved process that limits life activity. Cellular aging is the result of accumulated genetic damage, epigenetic damage and molecular exhaustion, as well as altered inter-cellular communication; these lead to impaired organ function and increased vulnerability to death. Skeletal muscle constitutes ~40% of the human body's mass. In addition to maintaining skeletal structure and allowing locomotion, which enables essential daily activities to be completed, skeletal muscle also plays major roles in thermogenesis, metabolism and the functioning of the endocrine system. Unlike many other organs that have a defined size once adulthood is reached, skeletal muscle is able to alter its structural and functional properties in response to changes in environmental conditions. Muscle mass usually remains stable during early life; however, it begins to decline at a rate of ~1% year in men and ~0.5% in women after the age of 50 years. On the other hand, different exercise training regimens are able to restore muscle homeostasis at the molecular, cellular and organismal levels, thereby improving systemic health. Here we give an overview of the molecular factors that contribute to lifespan and healthspan, and discuss the effects of the longevity gene Cisd2 and middle-to-old age exercise on muscle metabolism and changes in the muscle transcriptome in mice during very old age.
* exercise performance
* group III/IV muscle afferents
* neuromuscular fatigue
|full-text-url=https://sci-hub.do/10.1152/ajpregu.00151.2020
}}
{{medline-entry
|title=miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32009940


===MeSH Terms===
-


===Keywords===
|keywords=* Alzheimer’s disease
Cisd2; aging; exercise; metabolism; skeletal muscle
* aging
* blood
* miR-146a
* microRNA
* plasma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978630
}}
{{medline-entry
|title=Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31397211


==Cellular proteostasis decline in human senescence.==
===Abstract===
Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been established as a hallmark of nematode aging. However, whether proteostasis collapse occurs in humans has remained unclear. Here, we demonstrate that proteostasis decline is intrinsic to human senescence. Using transcriptome-wide characterization of gene expression, splicing, and translation, we found a significant deterioration in the transcriptional activation of the heat shock response in stressed senescent cells. Furthermore, phosphorylated HSF1 nuclear localization and distribution were impaired in senescence. Interestingly, alternative splicing regulation was also dampened. Surprisingly, we found a decoupling between different unfolded protein response (UPR) branches in stressed senescent cells. While young cells initiated UPR-related translational and transcriptional regulatory responses, senescent cells showed enhanced translational regulation and endoplasmic reticulum (ER) stress sensing; however, they were unable to trigger UPR-related transcriptional responses. This was accompanied by diminished ATF6 nuclear localization in stressed senescent cells. Finally, we found that proteasome function was impaired following heat stress in senescent cells, and did not recover upon return to normal temperature. Together, our data unraveled a deterioration in the ability to mount dynamic stress transcriptional programs upon human senescence with broad implications on proteostasis control and connected proteostasis decline to human aging.


===MeSH Terms===
|keywords=* Aging
-
* critical torque
* group III/IV muscle afferents
|full-text-url=https://sci-hub.do/10.1080/17461391.2019.1655099
}}
==CTSA==


===Keywords===
{{medline-entry
UPR; chaperones; heat shock response; protein homeostasis; senescence
|title=A [[CTSA]]-based consultation service to advance research on special and underserved populations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33244406


==The Neural Correlates of Visual and Auditory Cross-Modal Selective Attention in Aging.==
===Abstract===
Age-related deficits in selective attention have been demonstrated to depend on the sensory modality through which targets and distractors are presented. Some of these investigations suggest a specific impairment of cross-modal auditory selective attention. For the first time, this study is taking on a whole brain approach while including a passive perception baseline, to investigate the neural underpinnings of selective attention across age groups, and taking the sensory modality of relevant and irrelevant (i.e., distracting) stimuli into account. Sixteen younger (mean age = 23.3 years) and 14 older (mean age = 65.3 years), healthy participants performed a series of delayed match-to-sample tasks, in which participants had to selectively attend to visual stimuli, selectively attend to auditory stimuli, or passively view and hear both types of stimuli, while undergoing 3T fMRI. The imaging analyses showed that areas recruited by cross-modal visual and auditory selective attention in both age groups included parts of the dorsal attention and frontoparietal control networks (i.e., intraparietal sulcus, insula, fusiform gyrus, anterior cingulate, and inferior frontal cortex). Most importantly, activation throughout the brain did not differ across age groups, suggesting intact brain function during cross-modal selective attention in older adults. Moreover, stronger brain activation during cross-modal visual vs. cross-modal auditory selective attention was found in both age groups, which is consistent with earlier accounts of visual dominance. In conclusion, these results do not support the hypothesized age-related deficit of cross-modal auditory selective attention. Instead, they suggest that the underlying neural correlates of cross-modal selective attention are similar in younger and older adults.


===MeSH Terms===
|keywords=* faculty development
-
* geriatrics
* grant review
* grant studio
* pediatrics
* peer review
* research consultation service
* special populations
* underrepresented minorities
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681147
}}
==CTSB==


===Keywords===
{{medline-entry
aging; selective attention; sensory modality; top-down modulation; whole-brain fMRI
|title=Myocardial cathepsin D is downregulated in sudden cardiac death.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32176724


==Audio-Visual Training in Older Adults: 2-Interval-Forced Choice Task Improves Performance.==
|mesh-terms=* Adult
===Abstract===
* Aged
A growing interest in ameliorating multisensory perception deficits in older adults arises from recent evidence showing that impaired multisensory processing, particularly in the temporal domain, may be associated with cognitive and functional impairments. Perceptual training has proved successful in improving multisensory temporal processing in young adults, but few studies have investigated this training approach in older adults. In the present study we used a simultaneity (or synchronicity) judgement task with feedback, to train the audio-visual abilities of community-dwelling, cognitively healthy older adults. We recruited 23 older adults ([i]M[/i] = 74.17, [i]SD[/i] = 6.23) and a group of 20 young adults ([i]M[/i] = 24.20, [i]SD[/i] = 4.23) who served as a comparison. Participants were tested before and after perceptual training using a 2-Interval Forced Choice Task (2-IFC); and the Sound-Induced Flash Illusion (SIFI). After 3 days of training, participants improved on the 2-IFC task, with a significant narrowing of the temporal window of integration (TWI) found for both groups. Generalization of training effects was not found, with no post-training differences in perceptual sensitivity to the SIFI for either group. These findings provide evidence perceptual narrowing can be achieved in older as well as younger adults after 3 days of perceptual training. These results provide useful information for future studies attempting to improve audio-visual temporal discrimination abilities in older people.
* Aged, 80 and over
* Aging
* Cathepsin D
* Death, Sudden, Cardiac
* Down-Regulation
* Female
* Humans
* Male
* Middle Aged
* Myocardium
* Substrate Specificity


===MeSH Terms===
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075574
-
}}
==CX3CL1==


===Keywords===
{{medline-entry
aging; audio-visual; multisensory; perceptual learning; sound-induced flash illusion; training
|title=Two forms of [[CX3CL1]] display differential activity and rescue cognitive deficits in [[CX3CL1]] knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32410624


==Thermal Aging Rheological Behavior of Magnetorheological Elastomers Based on Silicone Rubber.==
===Abstract===
Engineering rubber composites have been widely used as main components in many fields including vehicle engineering and biomedical applications. However, when a rubber composite surface area is exposed to heat or sunlight and over a long-term accelerated exposure and lifecycle of test, the rubber becomes hard, thus influencing the mechanical and rheological behavior of the materials. Therefore, in this study, the deterioration of rheological characteristics particularly the phase shift angle (δ) of silicone rubber (SR) based magnetorheological elastomer (MRE) is investigated under the effect of thermal aging. SR-MRE with 60 wt% of CIPs is fabricated and subjected to a continuous temperature of 100 °C for 72 h. The characterization of SR-MRE before and after thermal aging related to hardness, micrograph, and rheological properties are characterized using low vacuum scanning electron microscopy (LV-SEM) and a rheometer, respectively. The results demonstrated that the morphological analysis has a rough surface and more voids occurred after the thermal aging. The hardness and the weight of the SR-MRE before and after thermal aging were slightly different. Nonetheless, the thermo-rheological results showed that the stress-strain behavior have changed the phase-shift angle (δ) of SR-MRE particularly at a high strain. Moreover, the complex mechanism of SR-MRE before and after thermal aging can be observed through the changes of the 'in-rubber structure' under rheological properties. Finally, the relationship between the phase-shift angle (δ) and the in-rubber structure due to thermal aging are discussed thoroughly which led to a better understanding of the thermo-rheological behavior of SR-MRE.


===MeSH Terms===
|keywords=* Aging
-
* CX3CL1
* Cognition
* Fractalkine
* Long-term potentiation
* Microglia
* Neurodegeneration
* Neurogenesis
* Neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227354
}}
==CX3CR1==


===Keywords===
{{medline-entry
Payne effect; magnetorheological elastomer; phase shift angle; rheological properties; thermal aging; thermo-rheological
|title=Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107839


==Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.==
===Abstract===
For the first time in history, most of the population has a life expectancy equal or greater than 60 years. By the year 2050, it is expected that the world population in that age range will reach 2000 million, an increase of 900 million with respect to 2015, which poses new challenges for health systems. In this way, it is relevant to analyze the most common diseases associated with the aging process, namely Alzheimer´s disease, Parkinson Disease and Type II Diabetes, some of which may have a common genetic component that can be detected before manifesting, in order to delay their progress. Genetic inheritance and epigenetics are factors that could be linked in the development of these pathologies. Some researchers indicate that the [i]BDNF[/i] gene is a common factor of these diseases, and apparently some of its polymorphisms favor the progression of them. In this regard, alterations in the level of BDNF expression and secretion, due to polymorphisms, could be linked to the development and/or progression of neurodegenerative and metabolic disorders. In this review we will deepen on the different polymorphisms in the [i]BDNF[/i] gene and their possible association with age-related pathologies, to open the possibilities of potential therapeutic targets.


===MeSH Terms===
|keywords=* DNA methylation
-
* aging
* glucose metabolism
* monocytes
* phosphatidylcholines
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189998
}}
{{medline-entry
|title=Muscle Injury Induces Postoperative Cognitive Dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066806


===Keywords===
|mesh-terms=* Aging
Aging; BDNF gene; aging-related diseases; polymorphism
* Animals
* Brain
* Brain-Derived Neurotrophic Factor
* CX3C Chemokine Receptor 1
* Cytokines
* Disease Models, Animal
* Hippocampus
* Humans
* Male
* Mice
* Microglia
* Muscle, Skeletal
* Nerve Growth Factor
* Postoperative Cognitive Complications
* Postoperative Complications


==Physical and Behavioral Health Characteristics of Aging Homeless Women in the United States: An Integrative Review.==
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026159
===Abstract===
}}
The average age of the homeless population is and will continue to rise. Although women comprise a significant and growing percentage of this vulnerable population, their age- and sex-specific health characteristics are poorly understood.  This integrative review appraises published research addressing the physical and behavioral health characteristics of aging homeless women (≥50 years) in the United States (2000-2019). The authors searched six electronic databases to identify eligible studies. Studies were screened for methodological quality by using the Johns Hopkins Nursing Evidence-Based Practice model. The review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.  Ten primary studies met the review eligibility criteria. All were level III (non-experimental); nine appraised as "good" quality (level B), and one as "lower" quality (level C). Aging homeless women demonstrate elevated rates of physical health conditions, related to suboptimal nutrition, lower than expected preventive health screening uptake, and geriatric concerns. Disproportionate rates of mental health conditions are compounded by substance use and interpersonal trauma. Familial and social dynamics and socioeconomic disadvantage contribute to social health concerns. Spiritual health is a critically important yet underexplored protective factor.  Studies are limited, though collective findings suggest that aging homeless women endure a disproportionate physical, behavioral, and social health burden compared with aging non-homeless women and aging homeless men. Implications for research on early aging, preventative health strategies, and homelessness among women, and clinical practice in the context of geriatric and women's health are described.
==CXCL1==


===MeSH Terms===
{{medline-entry
-
|title=Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026570


===Keywords===
aging; health disparities; homelessness; older adult; women's health


==Reading the Mind in the Eyes: A Population-Based Study of Social Cognition in Older Adults.==
|keywords=* SASP
===Abstract===
* cytokines
Social cognition indicates the cognitive processes involved in perceiving, interpreting, and processing social information. Although it is one of the six core DSM-5 cognitive domains for diagnosing neurocognitive disorders, it is not routinely assessed in older adults. The Reading the Mind in the Eyes Test assesses Theory of Mind, the social cognition mechanism which forms the root of empathy. To describe the distribution of, and factors associated with, scores on a 10-item version of Reading the Mind in the Eyes Test (RMET-10) in older adults. Population-based cross-sectional study. Small-town communities in Pennsylvania. Adults aged 66-105 years (N = 902, mean age = 76.6). The assessment included RMET-10, demographics, cognitive screening, literacy, depression symptoms, anxiety symptoms, cognitive composites derived from a neuropsychological test battery, Social Norms Questionnaire, and Clinical Dementia Rating (CDR). RMET-10 score was normally distributed in our overall study sample. Normative RMET-10 scores among those rated as CDR = 0 were calculated by age, sex, and education. RMET-10 score was significantly higher with younger age, higher education, white race, higher cognitive screening scores, literacy, social norms scores, higher scores in all five domains in cognitive composites, and lower CDR. RMET-10 score was also significantly higher with fewer depression and anxiety symptoms after adjusting for demographics. The RMET is a potentially useful measure of social cognition for use in the research assessment of older adults. With appropriate calibration it should also have utility in the clinical setting.
* inflammation
* paralysis
* senescence
* spinal cord injury
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002538
}}
{{medline-entry
|title=Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31507593


===MeSH Terms===
|mesh-terms=* Adult
-
* Aging
* Anti-HIV Agents
* Antiretroviral Therapy, Highly Active
* Biomarkers
* CD4 Lymphocyte Count
* Computational Biology
* Cross-Sectional Studies
* Disease Susceptibility
* Duration of Therapy
* Female
* HIV Infections
* Humans
* Inflammation
* Male
* Metabolome
* Metabolomics
* Middle Aged
* Proteomics
* Telomere Homeostasis
* Viral Load
|keywords=* HIV
* India
* LMIC (lower middle income country)
* inflammation markers
* long term antiretroviral therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718454
}}
==CXCL10==


===Keywords===
{{medline-entry
Aging; Reading the Mind in the Eyes Test (RMET); cognitive empathy; community-based; epidemiology; theory of mind
|title=Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32725722


==Strategies to Prevent Serious Fall Injuries: A Commentary on Bhasin et al. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. [i]N Engl J Med[/i]. 2020;383(2):129-140.==
===Abstract===
Every second of every day, an older adult suffers a fall in the United States (>30 million older adults fall each year). More than 20% of these falls cause serious injury (e.g., broken bones, head injury) and result in 800,000 hospitalizations and 30,000 deaths annually. Bhasin and colleagues recently reported results from a pragmatic, cluster-randomized trial designed to evaluate the effectiveness of a multifactorial intervention to prevent fall injuries. The intervention did not result in a significantly lower rate of a first adjudicated serious fall injury among older adults at increased risk for fall injuries as compared with enhanced usual care. In this commentary we briefly review and highlight these recent findings. Additionally, we argue that the findings should not be discounted just because of the lack of statistical significance. The approximately 10% reduction compared to enhanced usual care is, arguably, meaningful at both the individual and public health level, especially when one considers that the control group had better outcomes than expected based on prior work. Moreover, we encourage future research as well as practitioners to give strong consideration to the nuances of the exercise interventions for reducing falls and fall-related injuries particularly as it relates to exercise programming specifics, namely intensity and volume, to enhance neuromuscular function and also to neurorehabilitation approaches to enhance motor function (e.g., balance, motor planning, and coordination).


===MeSH Terms===
|keywords=* Aging
-
* CXCL10
* IFN-γ
* Macrophage
* Muscle regeneration
* Single-cell RNA sequence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567146
}}
==CXCL11==


===Keywords===
{{medline-entry
aging; fractures; frailty; mobility
|title=Endothelial cells under therapy-induced senescence secrete [[CXCL11]], which increases aggressiveness of breast cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659248


==Does dance counteract age-related cognitive and brain declines in middle-aged and older adults? A systematic review.==
===Abstract===
Dance is a multidomain activity that combines aerobic, coordination and cognitive exercise. This music-associated physical and cognitive exercise is a leisure activity that motivates people, elicits emotions, and avoids boredom, promoting adherence to practice. Continuing physical activity is of paramount importance, since cognitive benefits tend to disappear or even reverse when training ceases. The question we addressed in this systematic review is what influence dance has on the brain and cognition of healthy middle-aged and older adults. We systematically reviewed the effects of dance on brain and cognition in older adults using MEDLINE, Psyc-Info, PubMed and Scopus databases. After screening 1,051 studies, thirty-five met the eligibility inclusion criteria. These studies showed that dance improves brain structure and function as well as physical and cognitive functions. The protective effect of dance training on cognition in older adults, together with the possibility of adapting intensity and style to suit possible physical limitations makes this activity very suitable for older adults.


===MeSH Terms===
|keywords=* CXCL11
-
* Endothelial cells
* Therapy-induced senescence
* Tumor microenvironment
|full-text-url=https://sci-hub.do/10.1016/j.canlet.2020.06.019
}}
==CXCL12==


===Keywords===
{{medline-entry
Aging; dance; music; neuroplasticity; physical exercise
|title=Co-option of Neutrophil Fates by Tissue Environments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33098771


==Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.==
===Abstract===
The Chinese herbal formula Heshouwu decoction (Heshouwuyin) has protective effects on testicular function in aging male rats, but the mechanism is unknown. This study investigated whether Heshouwuyin affects the testicular function of aging rats by regulating the insulin/IGF signalling pathway. Sixteen-month-old male Wistar rats in the Heshouwuyin group and the natural-aging group were orally administered Heshouwuyin granules (0.056 g/kg) or equivalent normal saline for 60 d. The testicular tissue of 12-month-old male Wistar rats was removed as a young control group ([i]n[/i] = 10). The testicular tissue and spermatogenic cells were studied. The immunofluorescence results revealed that the insulin receptor (INSR)- (0.056 ± 0.00548), insulin receptor substrate 1(IRS1)- (0.251 ± 0.031), IRS2 (0.230 ± 0.019)- and insulin-like growth factor 1 (IGF1)-positive cell rate (0.33 ± 0.04) in the aging group was higher than that in the young control group (0.116 ± 0.011, 0.401 ± 0.0256, 0.427 ± 0.031, 0.56 ± 0.031; [i]p[/i] < 0.01), and the IGF-binding protein 3 (IGFBP3)-positive cell rate (0.42 ± 0.024) was lower than that (0.06 ± 0.027) in the young group ([i]p[/i] < 0.01). The intervention of Heshouwuyin reversed the above phenomena. The qPCR and immunoblot results were consistent with those of the immunofluorescence. The same results were obtained in spermatogenic cells. Our research shows that Heshouwuyin can regulate the insulin/IGF signalling pathway to improve testicular function, and provides an experimental basis for further clinical use.


===MeSH Terms===
|keywords=* angiogenesis
-
* immune heterogeneity
* immune niche
* innate immunity
* neutrophil lifespan
* neutrophils
* single-cell analysis
* tissue-resident cells
|full-text-url=https://sci-hub.do/10.1016/j.cell.2020.10.003
}}
{{medline-entry
|title=Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885181


===Keywords===
IGF1; IGFBP3; INSR; IRS1; IRS2; Male reproduction; senescence


==SOD1, more than just an antioxidant.==
|keywords=* aging
===Abstract===
* bone marrow
During cellular respiration, radicals, such as superoxide, are produced, and in a large concentration, they may cause cell damage. To combat this threat, the cell employs the enzyme Cu/Zn Superoxide Dismutase (SOD1), which converts the radical superoxide into molecular oxygen and hydrogen peroxide, through redox reactions. Although this is its main function, recent studies have shown that the SOD1 has other functions that deviates from its original one including activation of nuclear gene transcription or as an RNA binding protein. This comprehensive review looks at the most important aspects of human SOD1 (hSOD1), including the structure, properties, and characteristics as well as transcriptional and post-translational modifications (PTM) that the enzyme can receive and their effects, and its many functions. We also discuss the strategies currently used to analyze it to better understand its participation in diseases linked to hSOD1 including Amyotrophic Lateral Sclerosis (ALS), cancer, and Parkinson.
* cxcl12-abudant reticular cells
* endothelial cells
* niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001511
}}
{{medline-entry
|title=Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801092


===MeSH Terms===
|mesh-terms=* Aging
-
* Animals
* Bone Marrow
* Bone Marrow Cells
* Cell Differentiation
* Cells, Cultured
* Cellular Microenvironment
* Chemokine CXCL12
* Embryonic Development
* Endothelial Cells
* Gene Expression Profiling
* Hematopoiesis
* Hematopoietic Stem Cells
* Inflammation
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred C57BL
* Stem Cell Niche
* Transcriptome
|keywords=* aging
* bone marrow microenvironment
* hematopoietic stem cells
* inflammation
* niches
* stromal cells
* transcriptomics
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.11.004
}}
==CXCL13==


===Keywords===
{{medline-entry
Aging; Cancer; Neurodegenerative diseases; Post-translational modifications; Superoxide dismutase 1
|title=RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32642521


==Caregiver Well-Being and Burden: Variations by Race/Ethnicity and Care Recipient Nativity Status.==
===Abstract===
Despite growing diversity among the aging population and extensive previous research on racial/ethnic minority caregivers, little research has been conducted on the potentially unique experiences and outcomes of informal caregivers of foreign-born care recipients. Using nationally representative data and the Stress Process Model, the current study examined the differences in caregiver outcomes (care burden, psychological well-being, and self-rated health) by care recipient nativity status (U.S.-born vs. foreign-born) and the extent to which caregiver outcomes vary by care recipient nativity status and caregiver race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic, and Others). The current study used Round 5 of the National Health and Aging Trends Study and the National Study of Caregiving ([i]N[/i] = 1,436). We conducted ordinary least squares regression to analyze the differences in caregiver's outcomes by care recipient nativity status and caregiver race/ethnicity and to investigate the impacts of the inclusion of caregiving factors (background factors, primary stressors, secondary stressors, and resources). Regression analyses showed that only care burden significantly varied by care recipient nativity status after controlling for covariates. Caregivers of foreign-born care recipients reported a higher burden. However, when interactions of care recipient nativity status × caregiver race/ethnicity were introduced, non-Hispanic black and Hispanic caregivers of foreign-born care recipients were more likely to report better psychological well-being and self-rated health compared to their counterparts. Across caregiver groups, better caregiver-care recipient relationship quality and less caregiver chronic conditions were associated with less burden and better caregiver psychological well-being and self-rated health. Care recipient nativity status and caregiver race/ethnicity may have complex effects on caregiving experiences. Given the observed significant interaction effects for caregiver psychological well-being and self-rated health, cultural factors may affect the extent to which these caregivers appraise their caregiving. Future research should delve into the appropriate ways to assess care stress as well as resilience among each caregiver group. Our results indicate the need for research, education, and practice that assess cultural and within-group differences among caregivers and inform needed changes to structural barriers.


===MeSH Terms===
|keywords=* CXCR5
-
* FastQC
* RNA-Seq
* aging
* choroid
* mice
* retina
* retinal degeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334305
}}
==CXCL14==


===Keywords===
{{medline-entry
Caregivers; National Health and Aging Trends Study (NHATS) and the National Study of Caregiving (NSOC); Nativity status; Race/ethnicity
|title=Identification of genes associated with endometrial cell aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258951


==Age-related alterations of default mode network in autobiographical memory: Recent versus remote events.==
===Abstract===
Previous studies have shown that the vividness of autobiographical memory decreases over time, and older adults often retrieve fewer details than young adults. However, the age-by-temporal distance (i.e., recent versus remote events) effect on autobiographical memory and underlying neural mechanisms are less understood. We recruited 25 young adults and 27 older adults to perform an fMRI-adapted autobiographical memory task with different temporal distances. The results showed that older adults' vividness ratings were generally higher than that of young adults, but were less sensitive to temporal distances. For neural imaging, an age-by-temporal distance effect was found in the left precuneus, manifested as young adults had more activation for recent events than for remote events, whereas no temporal distance effect was found in older adults. Interestingly, for older adults, the temporal distance effect was reflected by functional connectivity within the default mode network (DMN), with a stronger anterior DMN-posterior DMN coupling for remote events than for recent events, whereas no temporal distance difference on functional connectivity was found in young adults. The results suggest that older adults exhibit age-related neural differences in both activation and functional connectivity during the processing of autobiographical memory with different temporal distances, shedding new light for the understanding of the relationship between the DMN, autobiographical memory, and aging.


===MeSH Terms===
|keywords=* CXCL12
-
* CXCL14
* IL17RB
* endometrial cell aging
* infertility
* quantitative
immunohistochemistry
|full-text-url=https://sci-hub.do/10.1093/molehr/gaaa078
}}
==CXCL8==


===Keywords===
{{medline-entry
aging; autobiographical memory; default mode network; functional connectivity; temporal distance
|title=Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041998


==A Perspective on Roles Played by Immunosenescence in the Pathobiology of Alzheimer's Disease.==
===Abstract===
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. Aging is the most significant risk factor for late-onset AD. The age-associated changes in the immune system are termed immunosenescence. A close connection between immunosenescence and AD is increasingly recognized. This article provides an overview of immunosenescence and evidence for its role in the pathogenesis of AD and possible mechanisms as well as the outlook for drug development.


===MeSH Terms===
|keywords=* Alzheimer's disease
-
* endothelial senescence
* gene expression
* neurofibrillary tangles
* plasma biomarkers
* tau pathology
* vascular dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525127
}}
==CXCL9==


===Keywords===
{{medline-entry
Alzheimer’s disease; aging; immunosenescence; inflammation
|title=[[CXCL9]] and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32393333


==The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
Endogenous salicylic acid (SA) regulates leaf senescence, but the underlying mechanism remains largely unexplored. The exogenous application of SA to living plants is not efficient for inducing leaf senescence. By taking advantage of probenazole (PBZ)-induced biosynthesis of endogenous SA, we previously established a chemical inducible leaf senescence system that depends on SA biosynthesis and its core signaling receptor NPR1 in Arabidopsis thaliana. Here, using this system, we identified WRKY46 and WRKY6 as key components of the transcriptional machinery downstream of NPR1 signaling. Upon PBZ treatment, the wrky46 mutant exhibited significantly delayed leaf senescence. We demonstrate that NPR1 is essential for PBZ/SA-induced WRKY46 activation, whereas WRKY46 in turn enhances NPR1 expression. WRKY46 interacts with NPR1 in the nucleus, binding to the W-box of the WRKY6 promoter to induce its expression in response to SA signaling. Dysfunction of WRKY6 abolished PBZ-induced leaf senescence, while overexpression of WRKY6 was sufficient to accelerate leaf senescence even under normal growth conditions, suggesting that WRKY6 may serve as an integration node of multiple leaf senescence signaling pathways. Taken together, these findings reveal that the NPR1-WRKY46-WRKY6 signaling cascade plays a critical role in PBZ/SA-mediated leaf senescence in Arabidopsis. This article is protected by copyright. All rights reserved.
* Aging
* Biomarkers
* Brazil
* Chagas Disease
* Chemokine CXCL10
* Chemokine CXCL9
* Cohort Studies
* Electrocardiography
* Female
* Humans
* Male
* Middle Aged
* Trypanosoma cruzi
|keywords=* Chagas disease
* Chemokines
* Cohort
* Cytokines
* Immune biomarkers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216412
}}
==CXCR2==


===MeSH Terms===
{{medline-entry
-
|title=CXCL5-[[CXCR2]] signaling is a senescence-associated secretory phenotype in preimplantation embryos.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32959976


===Keywords===
Leaf senescence; NPR1; Probenazole; Salicylic acid; WRKY46; WRKY6


==The relationship of existential well - being to identity, religious coping, mental and general health among Norwegian aging women.==
|keywords=* CXCL5
===Abstract===
* CXCR2
The aim of this study was to explore the relationship of existential spirituality to identity processing, religious coping and mental and general health among younger and older aged women in Norway. Participant's included 120 women aged 31-91 who took part in a postal survey. Results showed that both accommodative and balancing identity processes were associated with existential well -being among both the younger and older aged. Among the younger - aged, mental health was also significantly associated with existential well-being, Moreover, among the older aged, religious coping in the form of discontent, was found to be associated with existential well-being.
* SASP
* aging
* infertility
* preimplantation embryo
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576282
}}
{{medline-entry
|title=Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850866


===MeSH Terms===
-


===Keywords===
|keywords=* ageing
Identity; aging; women
* diabetes
* senescence
* senolytics
* wound healing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431694
}}
==CXCR3==


==Cyclic Ion Mobility Spectrometry Coupled to High-Resolution Time-of-Flight Mass Spectrometry Equipped with Atmospheric Solid Analysis Probe for the Molecular Characterization of Combustion Particulate Matter.==
{{medline-entry
===Abstract===
|title=Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/[[CXCR3]] axis.
Anthropogenic air pollution has a severe impact on climate and human health. The immense molecular complexity and diversity of particulate matter (PM) is a result of primary organic aerosol (POA) as well as secondary organic aerosols (SOAs). In this study, a direct inlet probe (DIP), i.e., atmospheric solids analysis probe (ASAP), with ion mobility high-resolution mass spectrometric detection is applied. Primary particulate matter emissions from three sources were investigated. Furthermore, photochemically aged emissions were analyzed. DIP introduction allowed for a direct analysis with almost no sample preparation and resulted in a complex molecular pattern. This pattern shifted through oxidation processes toward heavier species. For diesel emissions, the fuel's chemical characteristic is partially transferred to the particulate matter by incomplete combustion and characteristic alkylated series were found. Polycyclic aromatic hydrocarbons (PAHs) were identified as major contributors. Ion mobility analysis results in drift time profiles used for structural analysis. The apex position was used to prove structural changes, whereas the full-width-at-half-maximum was used to address the isomeric diversity. With this concept, the dominance of one or a few isomers for certain PAHs could be shown. In contrast, a broad isomeric diversity was found for oxygenated species. For the in-depth specification of fresh and aged spruce emissions, the ion mobility resolving power was almost doubled by allowing for three passes in the circular traveling wave design. The results prove that ASAP coupled with ion mobility spectrometry-mass spectrometry (IMS-MS) serves as a promising analytical approach for tackling the vast molecular complexity of PM.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31616512


===MeSH Terms===
-


===Keywords===
|keywords=* chemokine
combustion emission; complex mixtures; cyclic ion mobility spectrometry; direct inlet probe; high-resolution mass spectrometry; particulate matter (PM); photochemical aerosol aging
* hepatocyte
* natural killer cell
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781833
}}
==CXCR4==


==Neuroimmunomodulation by estrogen in health and disease.==
{{medline-entry
===Abstract===
|title=Aging-Related Reduced Expression of [[CXCR4]] on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.
Systemic homeostasis is maintained by the robust bidirectional regulation of the neuroendocrine-immune network by the active involvement of neural, endocrine and immune mediators. Throughout female reproductive life, gonadal hormones undergo cyclic variations and mediate concomitant modulations of the neuroendocrine-immune network. Dysregulation of the neuroendocrine-immune network occurs during aging as a cumulative effect of declining neural, endocrine and immune functions and loss of compensatory mechanisms including antioxidant enzymes, growth factors and co-factors. This leads to disruption of homeostasis and sets the stage for the development of female-specific age-associated diseases such as autoimmunity, osteoporosis, cardiovascular diseases and hormone-dependent cancers. Ovarian hormones especially estrogen, play a key role in the maintenance of health and homeostasis by modulating the nervous, endocrine and immune functions and thereby altering neuroendocrine-immune homeostasis. Immunologically estrogen's role in the modulation of Th1/Th2 immune functions and contributing to pro-inflammatory conditions and autoimmunity has been widely studied. Centrally, hypothalamic and pituitary hormones influence gonadal hormone secretion in murine models during onset of estrous cycles and are implicated in reproductive aging-associated acyclicity. Loss of estrogen affects neuronal plasticity and the ensuing decline in cognitive functions during reproductive aging in females implicates estrogen in the incidence and progression of neurodegenerative diseases. Peripherally, sympathetic noradrenergic (NA) innervations of lymphoid organs and the presence of both adrenergic (AR) and estrogen receptors (ER) on lymphocytes poise estrogen as a potent neuroimmunomodulator during health and disease. Cyclic variations in estrogen levels throughout reproductive life, perimenopausal surge in estrogen levels followed by its precipitous decline, concomitant with decline in central hypothalamic catecholaminergic activity, peripheral sympathetic NA innervation and associated immunosuppression present an interesting study to explore female-specific age-associated diseases in a new light.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32418119


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
17 β-estradiol; autoimmunity; immunosenescence; neural-immune; neuroendocrine; norepinephrine; reproductive aging
* CXCR4 and ROS
* HSPC
* MSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395885
}}
{{medline-entry
|title=Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/[[CXCR4]] signalling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32384208


==Exploring rural older adult perspectives on the scope, reach and sustainability of age-friendly programs.==
===Abstract===
Research into the sustainability of age-friendly initiatives is important and timely, particularly from the rather neglected perspective of older adults living in non-metropolitan (rural) environments. This paper addresses this gap by reporting on a Canadian rural community case study to understand the perspectives of older adults on the implementation and sustainability of their local age-friendly program. Findings from exploratory interviews with 10 older adults suggest that rural age-friendly initiatives may be limited in their ability to achieve larger-scale outcomes aimed at addressing broad aging issues facing rural communities. Further, our findings demonstrate that those 'aging in place' may continue to do so with the support of age-friendly programing, while those 'stuck in place' are largely unaffected by age-friendly programs. We advocate for additional in-depth examinations of rural age-friendly sustainability, including a greater emphasis on the diversity of older adult perspectives.


===MeSH Terms===
|keywords=* BPIFB4
-
* Cardiomyopathy
* Diabetes
* Gene therapy
* Longevity
|full-text-url=https://sci-hub.do/10.1002/ejhf.1840
}}
{{medline-entry
|title=Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658727


===Keywords===
|mesh-terms=* Animals
Age-friendly communities; Implementation; Older adults; Rural aging; Sustainability
* Blood Vessels
* Brain
* Cell Line
* Cellular Senescence
* Chemokine CXCL12
* Cranial Irradiation
* Disease Models, Animal
* Down-Regulation
* Endothelial Cells
* Female
* Gene Expression Regulation
* Humans
* Lipopeptides
* Mice
* Receptors, CXCR4
* Signal Transduction
|keywords=* CXCR4
* SDF-1
* brain disorder
* endothelial dysfunction
* ionizing radiation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830118
}}
==CYP11B1==


==Long-term sustainable phosphorus (P) retention in a low-P stormwater wetland for Everglades restoration.==
{{medline-entry
===Abstract===
|title=Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.
The Stormwater Treatment Areas (STAs) are large wetlands constructed for phosphorus (P) retention for Everglades restoration in south Florida (USA), and include areas of submerged aquatic vegetation (SAV) at a globally unprecedented scale (~12,000 ha). The goal of this study was to elucidate the fate of P retained in large-scale SAV wetlands, and the associated temporal trends in P removal and retention. In a well-performing, 929-ha SAV-dominated STA surface water flow-through treatment wetland, measurements of accrued soil depth and soil P storage performed every ~4-6 years revealed a steady-state longitudinal soil P enrichment profile established within the first ~4 years of flow-through operation. Subsequently, the SAV soils accrued P at a relatively steady rate (1.13 g P m  yr  for the entire 17-year period) without indication of temporal P enrichment, spatial expansion of soil P enrichment in the inflow region, or impairment of water column P removal efficiency. Phosphorus sequestration occurred via accumulation of new sedimentary material (0.9-1.5 cm yr ), rather than enrichment of existing soil. These soil surveys were accompanied by measurements of porewater SRP concentrations, soil P release under anoxia, and soil P fractions, which demonstrated that soil P release potential and concentrations of highly labile soil P generally decreased over time. These findings demonstrate that the P retention mechanisms operating within this large SAV wetland can be sustainable under managed steady-state conditions. Susceptibility of SAV to extreme environmental perturbations in this and other wetlands, however, remains a research priority.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002589


===MeSH Terms===
-


===Keywords===
|keywords=* CYP11B1
Longevity; P saturation; SAV wetlands; Soil accretion; Steady state
* CYP17A
* Cellular senescence
* Compact and clear cells
* Cortisol-producing adenoma
* PRKACA
|full-text-url=https://sci-hub.do/10.1016/j.jsbmb.2020.105764
}}
==CYP1A1==


==Stimulation of epidermal hyperplasia and tumorigenesis by resident p16 -expressing cells.==
{{medline-entry
===Abstract===
|title=Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.
p16  (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16  in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16  in early epidermal lesions, which could potentially be targeted by senolytic therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31522824


===MeSH Terms===
|mesh-terms=* Adult
-
* Aged
* Aged, 80 and over
* Asian Continental Ancestry Group
* Cheek
* Cohort Studies
* Cytochrome P-450 CYP1A1
* European Continental Ancestry Group
* Female
* Genome-Wide Association Study
* Humans
* Middle Aged
* Polymorphism, Single Nucleotide
* Risk Factors
* Skin Aging
* Skin Pigmentation
|keywords=* Candidate SNPs
* Chinese Han females
* GWAS
* Skin aging
|full-text-url=https://sci-hub.do/10.1016/j.jdermsci.2019.08.010
}}
==CYP26B1==


===Keywords===
{{medline-entry
CDKN2A; P16ink4a; Wnt; aging; epidermis; senescence
|title=Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32385093


==Age Patterning in Wild Chimpanzee Gut Microbiota Diversity Reveals Differences from Humans in Early Life.==
|mesh-terms=* Aging
===Abstract===
* Animals
Survival in primates is facilitated by commensal gut microbes that ferment otherwise indigestible plant matter, resist colonization by pathogens, and train the developing immune system.  However, humans are unique among primates in that we consume highly digestible foods, wean early, mature slowly, and exhibit high lifelong investments in maintenance.  These adaptations suggest that lifetime trajectories of human-microbial relationships could differ from those of our closest living relatives. Here, we profile the gut microbiota of 166 wild chimpanzees aged 8 months to 67 years in the Kibale National Park, Uganda and compare the patterns of gut microbial maturation to those previously observed in humans. We found that chimpanzee gut microbial alpha-diversity, composition, density, interindividual variation, and within-individual change over time varied significantly with age. Notably, gut microbial signatures in infants <2 years old were distinct across all five metrics. Infant chimpanzee guts were enriched in some of the same taxa prevalent in infant humans (e.g., Bifidobacterium, Streptococcus, and Bacteroides), and chimpanzee gut microbial communities, like those of humans, exhibited higher interindividual variation in infancy versus later in life. However, in direct contrast to human infants, chimpanzee infants harbored surprisingly high-diversity rather than low-diversity gut bacterial communities compared with older conspecifics. These data indicate differential trajectories of gut microbiota development in humans and chimpanzees that are consistent with interspecific differences in lactation, diet, and immune function. Probing the phenotypic consequences of differential early-life gut microbial diversity in chimpanzees and other primates will illuminate the life history impacts of the hominid-microbiome partnership.
* Female
* Isotretinoin
* Male
* Metaplasia
* Mice
* Neural Stem Cells
* Neurogenesis
* Olfactory Mucosa
* Olfactory Receptor Neurons
* Retinoic Acid 4-Hydroxylase
|keywords=* aging
* inositol-1,4,5-triphosphate
* metaplasia
* olfactory epithelium
* retinoic acid
* stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244205
}}
==CYP2C19==


===MeSH Terms===
{{medline-entry
-
|title=Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31750550


===Keywords===
aging; chimpanzee; development; diversity; gut microbiota; infancy; maturation; microbiome; primate; weaning


==Sex differences in risk factors for white matter hyperintensities in non-demented older individuals.==
|keywords=* citalopram
===Abstract===
* genetic polymorphism
White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic resonance imaging brain scans from 2 Australian cohorts were analyzed to extract WMH volumes. The objective of this study is to examine the moderation effect by sex in the association between known risk factors and WMH. The burden of WMH was significantly higher in women compared to men, especially in the deep WMH (DWMH). In the generalized linear model that included the interaction between sex and body mass index (BMI), there was a differential association of BMI with DWMH in men and women in the exploratory sample, that is, the Sydney Memory and Aging Study, n = 432, aged between 70 and 90. The finding of a higher BMI associated with a higher DWMH in men compared to women was replicated in the Older Australian Twins Study sample, n = 179, aged between 65 and 90. The risk factors of WMH pathology are suggested to have a different impact on the aging brains of men and women.
* geriatrics
* physiologically based pharmacokinetic modeling
|full-text-url=https://sci-hub.do/10.1002/jcph.1541
}}
{{medline-entry
|title=Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31454087


===MeSH Terms===
|mesh-terms=* Aged
-
* Aged, 80 and over
* Aging
* Cytochrome P-450 CYP2C19
* Cytochrome P-450 CYP2D6
* Drug Prescriptions
* Female
* Humans
* Liver-Specific Organic Anion Transporter 1
* Longitudinal Studies
* Male
* Middle Aged
* Pharmaceutical Preparations
* Pharmacogenomic Testing
* Precision Medicine
* Primary Health Care
* United Kingdom
|keywords=* clinical pharmacology
* general practice
* pharmacogenomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955399
}}
==CYP2E1==


===Keywords===
{{medline-entry
Aging; Body mass index (BMI); Cerebral small vessel disease; Neuroimaging; Obesity; Sex differences; White matter hyperintensity (WMH)
|title=DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221779


==Prevention of Fine Dust-Induced Vascular Senescence by [i]Humulus lupulus[/i] Extract and Its Major Bioactive Compounds.==
===Abstract===
Both short- and long-term exposure to fine dust (FD) from air pollution has been linked to various cardiovascular diseases (CVDs). Endothelial cell (EC) senescence is an important risk factor for CVDs, and recent evidence suggests that FD-induced premature EC senescence increases oxidative stress levels. Hop plant ([i]Humulus lupulus[/i]) is a very rich source of polyphenols known to have nutritional and therapeutic properties, including antioxidant behavior. The aims of this study were to evaluate whether [i]Humulus lupulus[/i] extract prevents FD-induced vascular senescence and dysfunction and, if so, to characterize the underlying mechanisms and active components. Porcine coronary arteries and endothelial cells were treated with FD in the presence or absence of hop extract (HOP), and the senescence-associated-beta galactosidase (SA-β-gal) activity, cell-cycle progression, expression of senescence markers, oxidative stress level, and vascular function were evaluated. Results indicated that HOP inhibited FD-induced SA-β-gal activity, cell-cycle arrest, and oxidative stress, suggesting that HOP prevents premature induction of senescence by FD. HOP also ameliorated FD-induced vascular dysfunction. Additionally, xanthohumol (XN) and isoxanthohumol (IX) were found to produce the protective effects of HOP. Treatment with HOP and its primary active components XN and IX downregulated the expression of p22 , p53, and angiotensin type 1 receptor, which all are known FD-induced redox-sensitive EC senescence inducers. Taken together, HOP and its active components protect against FD-induced endothelial senescence most likely via antioxidant activity and may be a potential therapeutic agent for preventing and/or treating air-pollution-associated CVDs.


===MeSH Terms===
|keywords=* Aging
-
* Cyp2e1
* DNA methylation
* Drug metabolism
* Histone acetylation
* Pharmacokinetics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287002
}}
==CYP7A1==


===Keywords===
{{medline-entry
Humulus lupulus; air pollution; endothelial dysfunction; endothelial senescence; fine dust; isoxanthohumol; oxidative stress; xanthohumol
|title=Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396457


==An Information Theory Approach for the Analysis of Individual and Combined Evaluation Parameters of Multiple Age-Related Diseases.==
===Abstract===
In view of the frequent presence of several aging-related diseases in geriatric patients, there is a need to develop analytical methodologies that would be able to perform diagnostic evaluation of several diseases at once by individual or combined evaluation parameters and select the most informative parameters or parameter combinations. So far there have been no established formal methods to enable such capabilities. We develop a new formal method for the evaluation of multiple age-related diseases by calculating the informative values (normalized mutual information) of particular parameters or parameter combinations on particular diseases, and then combine the ranks of informative values to provide an overall estimation (or correlation) on several diseases at once. Using this methodology, we evaluate a geriatric cohort, with several common age-related diseases, including cognitive and physical impairments (dementia, chronic obstructive pulmonary disease-COPD and ischemic heart disease), utilizing a set of evaluation parameters (such as demographic data and blood biomarkers) routinely available in geriatric clinical practice. This method permitted us to establish the most informative parameters and parameter combinations for several diseases at once. Combinations of evaluation parameters were shown to be more informative than individual parameters. This method, with additional clinical data, may help establish the most informative parameters and parameter combinations for the diagnostic evaluation of multiple age-related diseases and enhance specific assessment for older multi-morbid patients and treatments against old-age multimorbidity.


===MeSH Terms===
|keywords=* Aging
-
* Cytochrome P450’s
* Nuclear receptors
* Ontogeny
* Rat liver
* mRNA/protein expression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681801
}}
==DBI==


===Keywords===
{{medline-entry
aging; aging-related diseases; information theory; multimorbidity; normalized mutual information
|title=Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33000867


==Case Series and Review of Hematological and Non-Hematological Malignancies in Aging Patients with Sickle Cell Disease in the Hydroxyurea Era.==
===Abstract===
Survival of adult patients with sickle cell disease has increased progressively since the 1970s. Aging patients with sickle cell disease are at risk of developing comorbidities that are not due to sickle cell disease itself, including malignancies. Many studies tried to assess the incidence of malignancy in patients with sickle cell disease. However, no studies have been done to evaluate cancer incidences in aging sickle cell patients, especially in the hydroxyurea (HU) era. In this review, we assessed the prevalence of malignancies in aging patients with sickle cell disease at our institution with or without HU therapy. Retrospective analysis of hospital records identified patients who had been diagnosed to carry sickle cell disease and malignancies before 2020 using the International Statistical Classification of Diseases and Related Health Problems (ICD-10) coding. Four hundred and eighty-three sickle cell disease patients were seen in our inpatients/outpatients offices. Among these, 12 sickle cell disease patients had a confirmed diagnosis of malignancy. The patients were classified into three categories based on age groups: four patients who were 60 years and older had multiple myeloma. Solid tumors were found in 5/6 patients, aged 40-60 who had the Hb S ([i]HBB[/i]: c.20A>T) (β /β ) genotype with signs of iron overload. Two patients, aged 25 and 35, had hematological malignancies. The number of patients on HU was too small to make any comment on relationship to malignancy or mortality. This study is only one institution's experience, further investigation on a larger scale is needed to look into cancer incidences in this population.


===MeSH Terms===
|keywords=* aging
-
* cholinergic antagonists
* drug burden index
* drug utilization
* hypnotics and sedatives
* inappropriate prescribing
* pharmacoepidemiology
|full-text-url=https://sci-hub.do/10.1002/pds.5144
}}
{{medline-entry
|title=Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736845


===Keywords===
Aging sickle cell patients; hydroxyurea (HU); malignancies


==Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.==
|keywords=* Cognitive function
===Abstract===
* anti-muscarinics
Perineuronal nets (PNNs) are insoluble aggregates of extracellular matrix molecules in the brain that consist of hyaluronan (HA) and chondroitin sulfate proteoglycans (CSPGs). PNNs promote the acquisition and storage of memories by stabilizing the formation of synapses in the adult brain. Although the deterioration of PNNs has been suggested to contribute to the age-dependent decline in brain function, the molecular mechanisms underlying age-related changes in PNNs remain unclear. The amount and solubility of PNN components were investigated by sequential extraction followed by a disaccharide analysis and immunoblotting. We examined the interaction between HA and aggrecan, a major HA-binding CSPG, by combining mass spectrometry and pull-down assays. The solubility and amount of HA increased in the brain with age. Among several CSPGs, the solubility of aggrecan was selectively elevated during aging. In contrast to alternations in biochemical properties, the expression of PNN components at the transcript level was not markedly changed by aging. The increased solubility of aggrecan was not due to the loss of HA-binding properties. Our results indicated that the degradation of high-molecular-mass HA induced the release of the HA-aggrecan complex from PNNs in the aged brain. The present study revealed a novel mechanism underlying the age-related deterioration of PNNs in the brain.
* benzodiazepines
* geriatrics
* longitudinal
* mobility impairment
* physical function
* polypharmacy
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.05.037
}}
{{medline-entry
|title=Using the Drug Burden Index to identify older adults at highest risk for medication-related falls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532276


===MeSH Terms===
-


===Keywords===
|keywords=* Accidental falls
Brain aging; Chondroitin sulfate proteoglycan; Extracellular matrix; Hyaluronan; Perineuronal net
* Aging
* Health services
* Medication
* Medication therapy management
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291506
}}
{{medline-entry
|title=Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32315461


==Increased Social Interactions Reduce the Association Between Constricted Life-Space and Lower Daily Happiness in Older Adults With and Without HIV: A GPS and Ecological Momentary Assessment Study.==
===Abstract===
Older persons with human immunodeficiency virus (HIV) (PWH) are particularly susceptible to life-space restrictions. The aims of this study included: 1) using global positioning system (GPS) derived indicators as an assessment of time spent at home among older adults with and without HIV; 2) using ecological momentary assessment (EMA) to examine real-time relationships between life-space, mood (happiness, sadness, anxious), fatigue, and pain; and 3) determining if number of daily social interactions moderated the effect of life-space on mood. Eighty-eight older adults (PWH n = 54, HIV-negative n = 34) completed smartphone-based EMA surveys assessing mood, fatigue, pain, and social interactions four times per day for two weeks. Participants' smartphones were GPS enabled throughout the study. Mixed-effects regression models analyzed concurrent and lagged associations among life-space and behavioral indicators of health. PWH spent more of their time at home (79% versus 70%, z = -2.08; p = 0.04) and reported lower mean happiness (3.2 versus 3.7; z = 2.63; p = 0.007) compared to HIV-negative participants. Controlling for covariates, more daily social interactions were associated with higher ratings of real-time happiness (b = 0.12; t = 5.61; df = 1087.9; p< 0.001). Similar findings were seen in lagged analyses: prior day social interactions (b = 0.15; t = 7.3; df = 1024.9; p < 0.0001) and HIV status (b = -0.48; t = -2.56; df = 1026.8; p = 0.01) attenuated the effect of prior day time spent at home on happiness. Accounting for engagement in social interactions reduced the significant effect of time spent at home and lower happiness. Interventions targeting social isolation within the context of constricted life-space may be beneficial for increasing positive mood in older adults, and especially relevant to older PWH.


===MeSH Terms===
|keywords=* aging
-
* community pharmacy
* falls
* health services
* medication
|full-text-url=https://sci-hub.do/10.1111/jgs.16459
}}
==DBP==


===Keywords===
{{medline-entry
Remote assessment; aging; isolation; mobile health; mood; well-being
|title=Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32795629


==Black-white disparities during an epidemic: Life expectancy and lifespan disparity in the US, 1980-2000.==
===Abstract===
Covid-19 has demonstrated again that epidemics can affect minorities more than the population in general. We consider one of the last major epidemics in the United States: HIV/AIDS from ca. 1980-2000. We calculate life expectancy and lifespan disparity (a measure of variance in age at death) for thirty US states, finding noticeable differences both between states and between the black and white communities. Lifespan disparity allows us to examine distributional effects, and, using decomposition methods, we find that for six states lifespan disparity for blacks increased between 1980 and 1990, while life expectancy increased less than for whites. We find that we can attribute most of this to the impact of HIV/AIDS.


===MeSH Terms===
|keywords=* Aged
-
* Aging
* Exercise
* Exercise therapy
* High blood pressure
* Hypertension
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111052
}}
{{medline-entry
|title=Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32502600


===Keywords===
AIDS; HIV; Life expectancy; Lifespan disparity


==Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.==
|keywords=* Aging
===Abstract===
* Diastolic pressure
Rare perivascular mesenchymal stromal cells (MSCs) with therapeutic properties have been identified in many tissues. Their rarity necessitates extensive in vitro expansion, resulting in spontaneous differentiation, cellular senescence and apoptosis, producing therapeutic products with variable quality and decreased potency. We previously demonstrated that A83-01, a transforming growth factor beta (TGF-β) receptor inhibitor, maintained clonogenicity and promoted the potency of culture-expanded premenopausal endometrial MSCs using functional assays and whole-transcriptome sequencing. Here, we compared the effects of A83-01 on MSCs derived from postmenopausal endometrium, menstrual blood, placenta decidua-basalis, bone marrow and adipose tissue. Sushi-domain-containing-2 (SUSD2 ) and CD34 CD31 CD45  MSCs were isolated. Expanded MSCs were cultured with or without A83-01 for 7 days and assessed for MSC properties. SUSD2 identified perivascular cells in the placental decidua-basalis, and their maternal origin was validated. A83-01 promoted MSC proliferation from all sources except bone marrow and only increased SUSD2 expression and prevented apoptosis in MSCs from endometrial-derived tissues. A83-01 only improved the cloning efficiency of postmenopausal endometrial MSCs (eMSCs), and expanded adipose tissue MSCs (adMSCs) underwent significant senescence, which was mitigated by A83-01. MSCs derived from bone marrow (bmMSCs) were highly apoptotic, but A83-01 was without effect. A83-01 maintained the function and phenotype in MSCs cultured from endometrial, but not other, tissues. Our results also demonstrated that cellular SUSD2 expression directly correlates with the functional phenotype.
* Handgrip strength
* Post-exercise muscle ischemia
* Walking performance
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110984
}}
{{medline-entry
|title=The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32373010


===MeSH Terms===
-


===Keywords===
|keywords=* aging
SUSD2; adipose tissue; apoptosis; bone marrow; clonogenicity; endometrium; menstrual fluid; perivascular mesenchymal stromal cells; placenta; senescence
* blood pressure
* cognitive performance
* dementia
* sex differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186429
}}
{{medline-entry
|title=Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31995969


==Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin.==
===Abstract===
Estrogen is a pivotal signaling molecule; its production is regulated by the expression of the aromatase (CYP19A1) gene from ovarian and peripheral tissue sites, and it is transmitted via estrogen receptors to influence many important biological functions. However, the narrative for this overview focuses on the decline of 17β-estradiol levels from ovarian sites after menopause. This estrogen-deficient condition is associated with a dramatic reduction in skin health and wellness by negatively impacting dermal cellular and homeostatic mechanisms, as well as other important biological functions. The changes include loss of collagen, elastin, fibroblast function, vascularity, and increased matrix metalloproteinase(s) enzymatic activities, resulting in cellular and extracellular degradation that leads to dryness, wrinkles, atrophy, impaired wound healing/barrier function, decreased antioxidant capacity [i.e., defense against reactive oxygen species (ROS) and oxidative stress], decreased attractiveness and psychological health, and increased perception of aging. While topical estrogen may reverse these changes, the effects of today's low-dose systemic hormone treatments are not well established, raising the need for more concentrated local administration of hormones or newer cosmeceutical agents such as selective estrogen receptor modulators (SERMs), including phytoestrogens that have become major active ingredients for skin care products, especially when addressing estrogen-deficient skin. Two example compounds are presented, an analog of resveratrol (i.e., 4'-acetoxy resveratrol) and the isoflavonoid equol, both of which are involved in a variety of biochemical/molecular actions and mechanisms, as demonstrated via in vitro and clinical studies that enhance human dermal health, especially in estrogen-deficient skin.


===MeSH Terms===
|keywords=* Cognition
-
* Diastolic blood pressure
* Senility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992855
}}
{{medline-entry
|title=Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31910743


===Keywords===
|mesh-terms=* Aged
4′-Acetoxy resveratrol; Aging; Cosmeceuticals; Equol; Estrogen; Estrogen deficient skin; Hormone therapy; Menopause; Polyphenols; Skin
* Arterial Pressure
* Blood Pressure
* Brain
* Cohort Studies
* Diastole
* Female
* Frontal Lobe
* Humans
* Hypertension
* Linear Models
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Organ Size
* Parietal Lobe
* Prospective Studies
* Systole
* Temporal Lobe
* White Matter
|keywords=* American Heart Association
* blood pressure
* cerebrovascular disease
* cognitive aging
* white matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219602
}}
{{medline-entry
|title=Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31821404


==A Blockchain-Based Consent Platform for Active Assisted Living: Modeling Study and Conceptual Framework.==
===Abstract===
Recent advancements in active assisted living (AAL) technologies allow older adults to age well in place. However, sensing technologies increase the complexity of data collection points, making it difficult for users to consent to data collection. One possible solution for improving transparency in the consent management process is the use of blockchain, an immutable and timestamped ledger. This study aims to provide a conceptual framework based on technology aimed at mitigating trust issues in the consent management process. The consent management process was modeled using established methodologies to obtain a mapping of trust issues. This mapping was then used to develop a conceptual framework based on previous monitoring and surveillance architectures for connected devices. In this paper, we present a model that maps trust issues in the informed consent process; a conceptual framework capable of providing all the necessary underlining technologies, components, and functionalities required to develop applications capable of managing the process of informed consent for AAL, powered by blockchain technology to ensure transparency; and a diagram showing an instantiation of the framework with entities comprising the participants in the blockchain network, suggesting possible technologies that can be used. Our conceptual framework provides all the components and technologies that are required to enhance the informed consent process. Blockchain technology can help overcome several privacy challenges and mitigate trust issues that are currently present in the consent management process of data collection involving AAL technologies.


===MeSH Terms===
|keywords=* Aging
-
* Blood pressure
* Cardiovascular
* Genetics
* Single-nucleotide polymorphism
|full-text-url=https://sci-hub.do/10.1093/gerona/glz286
}}
{{medline-entry
|title=Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500574


===Keywords===
|mesh-terms=* Aged, 80 and over
Internet of Things; aging; blockchain; computer security; computing methodologies; health care; informed consent; mobile phone
* Blood Pressure
* Blood Pressure Determination
* China
* Female
* Health Surveys
* Humans
* Hypertension
* Longevity
* Longitudinal Studies
* Male
* Prevalence
|keywords=* Blood pressure
* Epidemiology
* Hypertension
* Oldest-old
* Prevalence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734230
}}
{{medline-entry
|title=The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443986


==An outpatient Tai Chi program: Effects on veterans' functional outcomes.==
|mesh-terms=* Age Factors
===Abstract===
* Aged
To evaluate the effectiveness of an evidence-based 12-week Tai Chi course designed to improve balance and physical function in a population of older veterans. Community dwelling veterans of all ages with gait and balance problems were invited to participate in the Tai Chi program. Participants completed the Berg Balance Scale (BBS), the Timed Up and Go (TUG) test, and the Falls Efficacy Scale-International (FES-I) at baseline and again at the end of the program. Descriptive statistics were used to summarize study participants' characteristics. The change from baseline to the end of the 12-week program was calculated for each of the three primary outcome variables (BBS, TUG, FES-I). Twenty-two veterans, aged 58 years and above, with perceived gait and/or balance issues were enrolled in the program with completion by 11 veterans. Veterans who completed their final assessments showed the BBS, improved significantly (p = 0.004) from baseline to the 12-week assessment. The TUG scores improved by a median of 1.3 s (p = 0.022). There was not a significant change in the FES-I. Preliminary findings provide evidence of the effectiveness of a 12-week Tai Chi program to improve functional outcomes for older veterans with mild to moderate gait and balance problems.
* Aged, 80 and over
* Aging
* Blood Pressure
* Cohort Studies
* Female
* Humans
* Male
* Middle Aged
|keywords=* Antihypertensive therapy
* Birth cohort effect
* Blood pressure
* Cohort study
* Heart disease
* Survival
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2019.08.011
}}
==DCC==


===MeSH Terms===
{{medline-entry
-
|title=X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31495695


===Keywords===
|mesh-terms=* Adenosine Triphosphatases
Tai Chi; balance; exercise; gait; geriatrics
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* DNA-Binding Proteins
* Dosage Compensation, Genetic
* Gene Expression Regulation
* Longevity
* Multiprotein Complexes
* X Chromosome
|keywords=* X chromosome dosage compensation
* aging
* condensin
* gene expression
* higher-order chromosome structure
* lifespan
* proteotoxic stress
* topologically associating domains
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810858
}}
==DCN==


==Acting Before; A Combined Strategy to Counteract the Onset and Progression of Dementia.==
{{medline-entry
===Abstract===
|title=Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.
Brain aging and aging-related neurodegenerative disorders are posing a significant challenge for health systems worldwide. To date, most of the therapeutic efforts aimed at counteracting dementia-related behavioral and cognitive impairment have been focused on addressing putative determinants of the disease, such as b-amyloid or tau. In contrast, relatively little attention has been paid to pharmacological interventions aimed at restoring or promoting the synaptic plasticity of the aging brain. The review will explore and discuss the most recent molecular, structural/functional, and behavioral evidence that supports the use of non-pharmacological approaches as well as cognitive-enhancing drugs to counteract brain aging and early-stage dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257596


===MeSH Terms===
-


===Keywords===
|keywords=* IGF-I
Aging; cognitive-enhancing drugs; dementia; exercise.; fMRI; hyper-connectivity; neuronal reserve; tau.
* aging
excitotoxicity. glutamate. cognitive stimulation; β-amyloid
* bone marrow mesenchymal stem cell
* osteoporosis
* small leucine-rich proteoglycan
|full-text-url=https://sci-hub.do/10.18632/aging.202166
}}
==DCX==


==Cigarette Smoke Directly Promotes Pulmonary Arterial Remodeling and Kv7.4 Channel Dysfunction.==
{{medline-entry
===Abstract===
|title=GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.
Cigarette smoke is considered the chief leading cause of chronic obstructive pulmonary disease (COPD). Its impact on the progressive deterioration of the airways has been extensively studied, but its direct effects on pulmonary vasculature are less known. We aim to prove that pulmonary arterial remodeling in COPD patients is not just a consequence of alveolar hypoxia, but it is also due to direct effects of cigarette smoke on the pulmonary vascular bed. We have used different molecular and cell biology approaches, as well as traction force microscopy, wire myography and patch-clamp techniques in human cells and freshly isolated pulmonary arteries. Additionally, we relied on in vivo models and human samples to analyze the effects of cigarette smoke on pulmonary vascular tone alterations. Cigarette smoke extract (CSE) exposure directly promoted a hypertrophic, senescent phenotype that in turn contributed, through the secretion of inflammatory molecules, to increase the proliferative potential of non-exposed cells. Interestingly, these effects were significantly reversed by antioxidants. Furthermore, CSE affected cell contractility and dysregulated the expression and activity of the voltage-gated K+ channel Kv7.4. This contributed to impair vasoconstriction and vasodilation responses. Most importantly, the levels of this channel were diminished in the lungs of smoke-exposed mice, smokers and COPD patients. Cigarette smoke directly contributes to pulmonary arterial remodeling through increased cell senescence, as well as vascular tone alterations due to diminished levels and function of the Kv7.4 channel. Strategies targeting these pathways may lead to novel therapies for COPD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863953


===MeSH Terms===
-


===Keywords===
|keywords=* Adult hippocampal neurogenesis
COPD; cell senescence; cigarette smoke; vascular remodeling; voltage-gated potassium channels
* Glycogen synthase kinase-3β
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449917
}}
{{medline-entry
|title=Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32236698


==Trajectories of Body Composition during Advanced Aging in Consideration of Diet and Physical Activity: A 20-Year Longitudinal Study.==
===Abstract===
This prospective study investigates age-dependent changes in anthropometric data and body composition over a period of two decades in consideration of physical activity and diet in community-dwelling subjects ≥60 years. Overall, 401 subjects with median follow-up time of 12 years were examined. Fat-free mass (FFM) and fat mass (FM) were analyzed using bioelectrical impedance analysis. Physical activity was assessed via a self-administered questionnaire. Dietary intake was examined by 3-day dietary records. Linear mixed-effects models were used to analyze the influence of age, sex, physical activity and energy/protein intake on anthropometric data and body composition by considering year of entry, use of diuretics and diagnosis of selected diseases. At baseline, median values for daily energy and protein intakes were 8.5 megajoule and 81 g and physical activity index was 1.7. After adjusting for covariates, advancing age was associated with parabolic changes indicating overall changes from age 60 to 90 years in women and men in body mass: -4.7 kg, -5.0 kg; body mass index: +0.04 kg/m , -0.33 kg/m ; absolute FFM: -2.8 kg, -3.5 kg; absolute FM: -1.8 kg, -1.2 kg and waist circumference: +16 cm, +12 cm, respectively. No age-dependent changes were found for upper arm circumference and relative (%) FFM. Dietary and lifestyle factors were not associated with changes in anthropometric or body composition parameters. In summary, the results indicate non-linear age-dependent changes in anthropometric data and body composition, which are largely unaffected by the degree of habitual physical activity and dietary protein intake in well-nourished community-dwelling subjects.


===MeSH Terms===
|keywords=* Aging
-
* DNA methylation
* Doublecortin
* Hippocampus
* IGF-1R
* mGluR5
|full-text-url=https://sci-hub.do/10.1007/s00726-020-02834-3
}}
==DDB1==


===Keywords===
{{medline-entry
aging; anthropometric data; body composition; longitudinal changes; physical activity; protein intake
|title=DCAF1 regulates Treg senescence via the ROS axis during immunological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32730228


==Improving care for residents in long term care facilities experiencing an acute change in health status.==
===Abstract===
Long term care (LTC) facilities provide health services and assist residents with daily care. At times residents may require transfer to emergency departments (ED), depending on the severity of their change in health status, their goals of care, and the ability of the facility to care for medically unstable residents. However, many transfers from LTC to ED are unnecessary, and expose residents to discontinuity in care and iatrogenic harms. This knowledge translation project aims to implement a standardized LTC-ED care and referral pathway for LTC facilities seeking transfer to ED, which optimizes the use of resources both within the LTC facility and surrounding community. We will use a quasi-experimental randomized stepped-wedge design in the implementation and evaluation of the pathway within the Calgary zone of Alberta Health Services (AHS), Canada. Specifically, the intervention will be implemented in 38 LTC facilities. The intervention will involve a standardized LTC-ED care and referral pathway, along with targeted INTERACT® tools. The implementation strategies will be adapted to the local context of each facility and to address potential implementation barriers identified through a staff completed barriers assessment tool. The evaluation will use a mixed-methods approach. The primary outcome will be any change in the rate of transfers to ED from LTC facilities adjusted by resident-days. Secondary outcomes will include a post-implementation qualitative assessment of the pathway. Comparative cost-analysis will be undertaken from the perspective of publicly funded health care. This study will integrate current resources in the LTC-ED pathway in a manner that will better coordinate and optimize the care for LTC residents experiencing an acute change in health status.


===MeSH Terms===
|keywords=* Aging
-
* Cellular senescence
* Immunology
* Inflammatory bowel disease
* T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598062
}}
==DDC==


===Keywords===
{{medline-entry
Community Paramedicine; Emergency departments; Geriatrics; Long term care; Long-term care; Mixed methods; Quality of care
|title=N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31530262


==Mini-Review on Lipofuscin and Aging: Focusing on The Molecular Interface, The Biological Recycling Mechanism, Oxidative Stress, and The Gut-Brain Axis Functionality.==
|mesh-terms=* Acetylcysteine
===Abstract===
* Aging
Intra-lysosomal accumulation of the autofluorescent "residue" known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as it continually accumulates. The latest evidence highlighted that lipofuscin strongly correlates with the excessive production of reactive oxygen species; however, despite this, lipofuscin cannot be removed by the biological recycling mechanisms. The antagonistic effects exerted at the DNA level culminate in a dysregulation of the cell cycle, by inducing a loss of the entire internal environment and abnormal gene(s) expression. Additionally, it appears that a crucial role in the production of reactive oxygen species can be attributed to gut microbiota, due to their ability to shape our behavior and neurodevelopment through their maintenance of the central nervous system.
* Animals
* Apoptosis
* Disease Models, Animal
* End Stage Liver Disease
* Humans
* Mice
* Muscle Fibers, Skeletal
* Muscular Atrophy
* Oxidative Stress
* Pyridines
* Sarcopenia
|keywords=* Sarcopenia
* UPP oxidative stress
* apoptosis
* chronic liver disease
* hepatotoxin.
|full-text-url=https://sci-hub.do/10.2174/1566524019666190917124636
}}
==DDO==
 
{{medline-entry
|title=New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561430
 
 
|keywords=* Brain aging
* Cell death
* L-Glutamate
* NMDA receptors
* d-Aspartate
* d-Aspartate oxidase
|full-text-url=https://sci-hub.do/10.1016/j.bbapap.2020.140471
}}
==DDT==
 
{{medline-entry
|title=Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388503
 
 
|keywords=* Aging
* Alzheimer’s disease
* Auditory processing
* Cognition
* Dichotic Digits Test
|full-text-url=https://sci-hub.do/10.1159/000506621
}}
{{medline-entry
|title=Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061977
 
|mesh-terms=* Animals
* DDT
* Hexachlorocyclohexane
* Hydrophobic and Hydrophilic Interactions
* Kinetics
* Oligochaeta
* Polychlorinated Biphenyls
* Pyrenes
* Soil Pollutants
|keywords=* Aging
* BAFs
* Bioaccumulation
* HOCs
* Laboratory-contaminated soils
|full-text-url=https://sci-hub.do/10.1016/j.ecoenv.2020.110317
}}
{{medline-entry
|title=Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31911208
 
 
|keywords=* Aging
* Anxiety-related behavior
* DDT
* Neurobehavioral toxicology
* Zebrafish
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061078
}}
{{medline-entry
|title=Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31910892
 
|mesh-terms=* Animals
* Anopheles
* Drug Resistance
* Female
* Fertility
* Insecticides
* Larva
* Male
* Metals
* Reproduction
* Water Pollutants
|keywords=* Anopheles arabiensis
* Insecticide resistance
* Longevity
* Transgenerational effects
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947826
}}
{{medline-entry
|title=Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765701
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Chemical and Drug Induced Liver Injury
* Dichlorodiphenyl Dichloroethylene
* Down-Regulation
* Liver
* Male
* Mice
* Oxidative Stress
* Pesticides
* Plant Extracts
* Polyphenols
* Transcriptome
* Up-Regulation
* Vitis
|keywords=* Aging
* Hepatoprotection
* Mus spretus
* Organochlorine
* Oxidative damage
* Pedro-ximénez grape must
* Transcriptional analysis
* p,p'-DDE
|full-text-url=https://sci-hub.do/10.1016/j.fct.2019.110984
}}
{{medline-entry
|title=Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31589084
 
|mesh-terms=* Adult
* B-Lymphocytes
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Cytokines
* Dose-Response Relationship, Drug
* Endosulfan
* Female
* Healthy Volunteers
* Humans
* Inflammation Mediators
* Insecticides
* Killer Cells, Natural
* Male
* Primary Cell Culture
* T-Lymphocytes, Cytotoxic
* Young Adult
|keywords=* Endosulfan
* Immunosenescence
* NK cells
* PBMC
* cytotoxic cells
* interferon
* organochlorine pesticide
* senescence
|full-text-url=https://sci-hub.do/10.1080/1547691X.2019.1668513
}}
==DKC1==
 
{{medline-entry
|title=Successful liver transplantation in short telomere syndromes without bone marrow failure due to [[DKC1]] mutation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32166868
 
 
|keywords=* DKC1
* cell death: senescence
* cirrhosis
* hepatopulmonary syndrome
* liver transplantation
* short telomere syndromes
|full-text-url=https://sci-hub.do/10.1111/petr.13695
}}
==DLD==
 
{{medline-entry
|title=A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32996650
 
 
|keywords=* Alzheimer's disease
* Down syndrome
* aging
* cerebral blood flow
* neuroimaging
|full-text-url=https://sci-hub.do/10.1111/jir.12784
}}
==DLGAP2==
 
{{medline-entry
|title=Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877673
 
 
|keywords=* Alzheimer’s
* Diversity Outbred
* Dlgap2
* GWAS
* aging
* cognition
* genetic diversity
* resilience
* spines
* susceptibility
* translational
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502175
}}
==DLX5==
 
{{medline-entry
|title=Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent [[DLX5]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856377


===MeSH Terms===
-


===Keywords===
|keywords=* adipogenic differentiation
aging; autophagy; gut–brain axis; lipofuscin; molecular biology; oxidative stress
* cell senescence
* distal-less homeobox 5
* lysine demethylase 4B
* mesenchymal stem cells
* microRNA-27b-3p
* osteoarthritis pain
* osteogenic differentiation
|full-text-url=https://sci-hub.do/10.1002/biof.1670
}}
==DMD==


==Effects of Aging on Expression of [i]Mic60[/i] and [i]OPA1[/i] and Mitochondrial Morphology in Myocardium of Tibetan Sheep.==
{{medline-entry
===Abstract===
|title=Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients.
In order to investigate the effects of aging on the expression of [i]Mic60[/i] and [i]OPA1[/i] and mitochondrial morphology in plateau animals, the expression of [i]Mic60[/i] and [i]OPA1[/i] genes and proteins, and the morphology of mitochondria in the myocardium of adult and aged Tibetan sheep were investigated. The expression of [i]Mic60[/i] and [i]OPA1[/i] genes and [i]OPA1[/i] protein were higher ([i]p[/i] < 0.05) in the myocardium of adult Tibetan sheep than in those of the aged ones. The number of mitochondrial cristae in the myocardium of adult was higher than that in aged ([i]p[/i] < 0.05). The density of mitochondria in the myocardium of adult was higher than that in aged ([i]p[/i] < 0.01). Compared with the adult Tibetan sheep, the mitochondrial crista of aged were relatively sparse, the crista membrane was wide, and the mitochondria were not closely linked, showing fragmentation. These results suggest that the myocardial mitochondria of the adult have better energy supply ability, indicating that aging can lead to the weakening of oxygen supply in the myocardial mitochondria of Tibetan sheep.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32157826


===MeSH Terms===
-


===Keywords===
|keywords=* Aging
Mic60; OPA1; Tibetan sheep; aging; myocardial mitochondria
* Aldehyde dehydrogenase
* Dog model
* Duchenne muscular dystrophy
* Human
* Myogenic
* Non-human primate
* Skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432589
}}
{{medline-entry
|title=Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107739


==Examining the effects of training on young and older adult implementation of spaced retrieval strategies.==
|mesh-terms=* Female
===Abstract===
* Humans
Although the benefits of spaced retrieval are well established, research suggests that young and older adults often fail to optimally implement this strategy. The present study examined how task experience with feedback influenced participant-implemented spaced retrieval and its effect on short and long-term memory retention. Young and older adults were instructed to either equally space or expand their retrieval of face-name associations throughout an ongoing reading task. Participants were then provided feedback on the accuracy with which they implemented experimenter instructions. Results showed that feedback improved utilization of retrieval practice in both young and older adults. Moreover, both age groups successfully produced a pattern of expanded retrieval when instructed to do so, but failed to properly implement equal spacing. Consistent with extant research utilizing experimenter-determined spaced retrieval schedules, our study showed that the inclusion of a longer spacing interval immediately following acquisition resulted in reduced forgetting across the retention interval.
* Life Expectancy
* Male
* Muscular Dystrophy, Duchenne
* Parturition
* Pregnancy
* Prognosis
* Quality of Life
* Respiration, Artificial
* Survival
|keywords=* Mechanical ventilation
* Mortality
* Prognosis
* Survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387367
}}
{{medline-entry
|title=Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31725904


===MeSH Terms===
|mesh-terms=* Adolescent
-
* Adult
* Aging
* Child
* Child, Preschool
* Cystatin C
* Disease Progression
* Female
* Heart Diseases
* Heart Function Tests
* Humans
* Kidney Diseases
* Kidney Function Tests
* Male
* Muscular Dystrophy, Duchenne
* Risk Factors
* Young Adult
|keywords=* Duchenne muscular dystrophy
* advanced stage
* cystatin C
* ejection fraction
* fractional shortening
* renal dysfunction
|full-text-url=https://sci-hub.do/10.1002/mus.26757
}}
==DNAJB9==


===Keywords===
{{medline-entry
Memory; aging; metacognition; spaced retrieval; testing effect
|title=[[DNAJB9]] Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32264658


==Neighborhood social environment and changes in leukocyte telomere length: The Multi-Ethnic Study of Atherosclerosis (MESA).==
===Abstract===
Given limited research on the impact of neighborhood environments on accelerated biological aging, we examined whether changes in neighborhood socioeconomic and social conditions were associated with change in leukocyte telomere length using 10 years of longitudinal data from the Multi-Ethnic Study of Atherosclerosis (years 2000-2011; N = 1031; mean age = 61, SD = 9.4). Leukocyte telomere length change was corrected for regression to the mean and neighborhood was defined as census tract. Neighborhood socioeconomic indicators (factor-based score of income, education, occupation, and wealth of neighborhood) and neighborhood social environment indicators (aesthetic quality, social cohesion, safety) were obtained from the U.S Census/American Community Survey and via study questionnaire, respectively. Results of linear mixed-effects models showed that independent of individual sociodemographic characteristics, each unit of improvement in neighborhood socioeconomic status was associated with slower telomere length attrition over 10-years (β = 0.002; 95% Confidence Interval (CI): 0.0001, 0.004); whereas each unit of increase in safety (β = -0.043; 95% CI: -0.069, -0.016) and overall neighborhood social environment score (β = -0.005; 95% CI: -0.009, -0.0004) were associated with more pronounced telomere attrition, after additionally adjusting for neighborhood socioeconomic status. This study provides support for considerations of the broader social and socioeconomic contexts in relation to biological aging. Future research should explore potential psychosocial mechanisms underlying these associations using longitudinal study designs with repeated observations.


===MeSH Terms===
|keywords=* DNAJB9
-
* RAS
* p53
* senescence
* transformation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191047
}}
==DNMT1==


===Keywords===
{{medline-entry
Biological aging; Neighborhood social environment; Neighborhood socioeconomic disadvantage; Telomere length
|title=DNA Methyltransferase 1 ([[DNMT1]]) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793592


==Absorption properties and forcing efficiency of light-absorbing water-soluble organic aerosols: Seasonal and spatial variability.==
===Abstract===
Light-absorbing organic aerosols, also known as brown carbon (BrC), enhance the warming effect of the Earth's atmosphere. The seasonal and spatial variability of BrC absorption properties is poorly constrained and accounted for in the climate models resulting in a substantial underestimation of their radiative forcing estimates. This study reports seasonal and spatial variability of absorption properties and simple forcing efficiency of light-absorbing water-soluble organic carbon (WSOC, SFE ) by utilizing current and previous field-based measurements reported mostly from Asia along with a few observations from Europe, the USA, and the Amazon rainforest. The absorption coefficient of WSOC at 365 nm (b ) and the concentrations of carbonaceous species at Kanpur were about an order of magnitude higher during winter than in the monsoon season owing to differences in the boundary layer height, active sources and their strengths, and amount of seasonal wet precipitation. The WSOC aerosols during winter exhibited ∼1.6 times higher light absorption capacity than in the monsoon season at Kanpur site. The assessment of spatial variability of the imaginary component of the refractive index spectrum (k ) across South Asia has revealed that it varies from ∼1 to 2 orders of magnitude and light absorption capacity of WSOC ranges from 3 to 21 W/g. The light absorption capacity of WSOC aerosols exhibited less spatial variability across East Asia (5-13 W/g) when compared to that in the South Asia. The photochemical aging of WSOC aerosols, indicated by the enhancement in WSOC/OC ratio, was linked to degradation in their light absorption capacity, whereas the absorption Ångström exponent (AAE) remained unaffected. This study recommends the adoption of refined climate models where sampling regime specific absorption properties are calculated separately, such that these inputs can better constrain the model estimates of the global effects of BrC.


===MeSH Terms===
|keywords=* DNA methylation
-
* GABA
* aging
* cerebral cortex
* inhibitory interneurons
* proteostasis
* synapse
* transcriptional control
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387673
}}
==DNMT3A==


===Keywords===
{{medline-entry
Absorption ångström exponent; Asia; Light absorption capacity; Photochemical aging; Refractive index
|title=Epigenetic regulation of miR-29a/miR-30c/[[DNMT3A]] axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961441


==Genetic Inhibition of sFRP3 Prevents Glial Reactivity in a Mouse Model of Accelerated Aging.==
===Abstract===
Aging is the most significant risk factor for neurodegenerative disorders that are typified by cognitive deficits. Our recent work utilizing BubR1 hypomorphic (BubR1H/H) mice, an accelerated aging model, has revealed that genetic inhibition of the endogenous Wnt pathway inhibitor secreted frizzled related protein 3 (sFRP3) plays a neuroprotective role. Neuroinflammation has been suggested as a pathological hallmark of age-related neurodegeneration mediating cognitive impairment. However, whether sFRP3 inhibition has a neuroprotective effect on neuroinflammatory gliosis in BubR1H/H mice is unknown. To investigate neuroprotection from aging-related neuroinflammation by sFRP3 in vivo, we generated double Bub R1H/H;sfrp3 knockout mice and performed immunohistological analysis with cell type-specific markers for astrocytes (glial fibrillary acidic protein), and microglia (ionized calcium-binding adapter molecule 1). Given that the hippocampus is a brain structure critical for learning and memory, and is uniquely affected in aging-related neurodegeneration, we evaluated morphological changes on astrocytes and microglia via confocal imaging. We demonstrate that BubR1H/H mice exhibit significantly increased levels of astrogliosis and an increased trend of microglial activation in the hilus and molecular layer of the young adult hippocampus, thus suggesting that BubR1 insufficiency accelerates glial reactivity. Importantly, our results further show that genetic inhibition of sFRP3 significantly recovers the astrogliosis and microglial activation observed in BubR1H/H mice, suggesting a critical neuroprotective role for sFRP3 in age-related neuroinflammation. Our findings suggest that sFRP3 inhibition may represent a novel therapeutic strategy for neurodegeneration.


===MeSH Terms===
|keywords=* Cellular senescence
-
* DNMT3A
* Human mesenchymal stem cells
* Mitochondrial oxidative stress
* SOD2
* microRNAs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509080
}}
{{medline-entry
|title=Collagens and DNA methyltransferases in mare endometrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512314


===Keywords===
|mesh-terms=* Aging
Aging; BubR1H/H mice; Neuroinflammation; Neuroprotection; sFRP3
* Animals
* Collagen
* DNA (Cytosine-5-)-Methyltransferases
* DNA Methylation
* Endometritis
* Endometrium
* Female
* Fibrosis
* Horse Diseases
* Horses
* RNA, Messenger
|keywords=* DNA methylation
* collagen
* endometrium
* epigenetic
* fibrosis
* mare
|full-text-url=https://sci-hub.do/10.1111/rda.13515
}}
{{medline-entry
|title=Age-related clonal haemopoiesis is associated with increased epigenetic age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31430471


==Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19.==
|mesh-terms=* Aged
===Abstract===
* Aged, 80 and over
---
* Aging
* Epigenesis, Genetic
* Female
* Hematopoiesis
* Humans
* Longitudinal Studies
* Male
* Risk Factors
* Scotland


===MeSH Terms===
|full-text-url=https://sci-hub.do/10.1016/j.cub.2019.07.011
-
}}
==DNMT3L==


===Keywords===
{{medline-entry
Alzheimer’s disease; COVID-19; Cholinergic anti-inflammatory pathway (CAP); Immunosenescence
|title=Transient [[DNMT3L]] Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32195249
 
 
|keywords=* DNA methyltransferase 3-like (DNMT3L)
* chromatin surveillance
* epigenetics
* polycomb repressive complex 2 (PRC2)
* senescence
* transposable element (TE)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064442
}}
==DOCK11==
 
{{medline-entry
|title=[Immunosenescence: The Forefront of Infection and Trophic Control].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115558
 
|mesh-terms=* Aging
* Animals
* B-Lymphocytes
* Cytokinesis
* Gene Expression
* Guanine Nucleotide Exchange Factors
* Humans
* Immunoglobulin M
* Immunosenescence
* Mice
* Nutritional Status
* Streptococcus pneumoniae
|keywords=* B-1a B cell
* dedicator of cytokinesis 11
* immunosenescence
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-3
}}
==DPP4==
 
{{medline-entry
|title=Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-[[DPP4]] Axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013423
 
 
|keywords=* DNA damage
* aging
* cellular senescence
* chronic obstructive pulmonary diseases
* idiopathic pulmonary fibrosis
* mitochondria
* smokers
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510459
}}
{{medline-entry
|title=Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32251672
 
 
|keywords=* Aging
* Dipeptidyl peptidase-4
* Endothelium
* Oxidative stress
* Vascular
|full-text-url=https://sci-hub.do/10.1016/j.bcp.2020.113951
}}
{{medline-entry
|title=Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31999643
 
 
|keywords=* Aging
* Cancer
* Hepatology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190991
}}
==DPP6==
 
{{medline-entry
|title=A novel structure associated with aging is augmented in the [[DPP6]]-KO mouse brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33225987
 
 
|keywords=* Aging dementia
* Alzheimer’s disease
* DPP6
* Presynaptic terminals
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682109
}}
==DPYSL2==
 
{{medline-entry
|title=Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733664
 
|mesh-terms=* Alcohol Drinking
* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Behavior, Animal
* Brain
* Disease Models, Animal
* Mice, Transgenic
* tau Proteins
|keywords=* Aging
* Amyloid beta
* Ethanol
* GSK
* Immunohistochemistry
* Morris Water Maze
* Prepulse inhibition
* Self-administration
* Tau pathology
* Transgenic mouse model
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939615
}}
==DRD1==
 
{{medline-entry
|title=Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32448293
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Exercise
* Humans
* Receptors, Dopamine
* Sedentary Behavior
* Sweden
|keywords=* Accelerometery
* Aging
* Dopamine
* Genes
* Physical activity
* Sedentary behaviour
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245799
}}
==DRD2==
 
{{medline-entry
|title=Cortical thickness mediates the relationship between [[DRD2]] C957T polymorphism and executive function across the adult lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33179159
 
 
|keywords=* Aging
* Cortical thickness
* DRD2
* Dopamine
* Executive function
|full-text-url=https://sci-hub.do/10.1007/s00429-020-02169-5
}}
{{medline-entry
|title=The relationship of age and [[DRD2]] polymorphisms to frontostriatal brain activity and working memory performance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31629117
 
|mesh-terms=* Aging
* Brain
* Humans
* Memory, Short-Term
* Polymorphism, Genetic
* Receptors, Dopamine D2
|keywords=* Aging
* C957T
* DRD2
* Dopamine
* Working memory
* fMRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.08.022
}}
==DSPP==
 
{{medline-entry
|title=Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32967298
 
 
|keywords=* aged teeth
* apoptosis
* dental pulp stem cells
* differentiation
* pulp regeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555360
}}
==DST==
 
{{medline-entry
|title=Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268207
 
|mesh-terms=* Aging
* Animals
* Biological Evolution
* DNA Replication
* Humans
* Phylogeny
|keywords=* Aging
* Asymmetric cell division
* DNA replication
* Disposable Soma Theory
* Epigenetics
* Evolution
* Germen/Soma
* Prokaryotes
* Protists
* Rejuvenation
* Unicellular
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101064
}}
==DUSP1==
 
{{medline-entry
|title=miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32348937
 
 
|keywords=* aging
* cardiac fibrosis
* dual-specificity phosphatases
* extracellular matrix
* miR-1468-3p
* microRNA
* p38
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191129
}}
==DUSP8==
 
{{medline-entry
|title=MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400088
 
|mesh-terms=* Aging
* Animals
* Antagomirs
* Anti-Inflammatory Agents
* Cells, Cultured
* Cerebral Hemorrhage
* Dual-Specificity Phosphatases
* HEK293 Cells
* Heme Oxygenase-1
* Hemin
* Humans
* Male
* MicroRNAs
* Rats
* Rats, Sprague-Dawley
* Signal Transduction
|keywords=* aging
* dual-specificity phosphatase 8
* haem oxygenase-1
* intracerebral haemorrhage
* microRNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826124
}}
==DUT==
 
{{medline-entry
|title=Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis [[DUT]]1805.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388689
 
 
|keywords=* Aging paddy rice with hull (APRH)
* Corn steep liquor powder (CSLP)
* High-thermotolerance
* Lactic acid
* Saccharification and fermentation (SLSF)
* Simultaneous liquification
|full-text-url=https://sci-hub.do/10.1007/s00449-020-02364-y
}}
==DYRK1A==
 
{{medline-entry
|title=Altered age-linked regulation of plasma [[DYRK1A]] in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32642550
 
 
|keywords=* Alzheimer's disease
* aging
* blood marker
* immunometric test
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331462
}}
==E2F1==
 
{{medline-entry
|title=Regulation of [[E2F1]] activity via PKA-mediated phosphorylations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33110360
 
 
|keywords=* E2F1
* PKA
* cell cycle
* forskolin
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585165
}}
{{medline-entry
|title=Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32412100
 
 
|keywords=* cell signal pathway
* nerve cells
* radiation
* senescence
|full-text-url=https://sci-hub.do/10.1111/jphp.13284
}}
==ECD==
 
{{medline-entry
|title=Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837315
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Cell Count
* Cornea
* Descemet Stripping Endothelial Keratoplasty
* Donor Selection
* Endothelium, Corneal
* Female
* Fuchs' Endothelial Dystrophy
* Humans
* Male
* Middle Aged
* Retrospective Studies
* Tissue Donors
* Treatment Outcome
* Visual Acuity
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1016/j.ajo.2019.12.001
}}
==EDA==
 
{{medline-entry
|title=Interplay between aging, lung inflammation/remodeling, and fibronectin [[EDA]] in lung cancer progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33222614
 
 
|keywords=* Lung cancer
* aging
* fibronectin EDA
* fibrosis
* inflammation
* lewis lung carcinoma
* metastasis
|full-text-url=https://sci-hub.do/10.1080/15384047.2020.1831372
}}
{{medline-entry
|title=Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32854302
 
 
|keywords=* aging adults
* arousal
* electrodermal activity
* musical genres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506973
}}
{{medline-entry
|title=The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31761592
 
|mesh-terms=* Adsorption
* Agriculture
* Ecosystem
* Environmental Pollutants
* Hydrogen Peroxide
* Microplastics
* Models, Chemical
* Naphthalenes
* Organic Chemicals
* Phenanthrenes
* Plastics
* Polycyclic Aromatic Hydrocarbons
* Polyethylene
* Polypropylenes
* Polyurethanes
* Polyuria
* Pyrenes
* Salinity
|keywords=* Aging
* Microplastics
* Polycyclic aromatic hydrocarbons
* Salinity
* Sorption
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2019.113525
}}
==EDARADD==
 
{{medline-entry
|title=Age prediction in living: Forensic epigenetic age estimation based on blood samples.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721866
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Child
* Child, Preschool
* CpG Islands
* Cyclic Nucleotide Phosphodiesterases, Type 4
* DNA Methylation
* Edar-Associated Death Domain Protein
* Fatty Acid Elongases
* Female
* Forensic Genetics
* Humans
* Infant
* LIM-Homeodomain Proteins
* Male
* Middle Aged
* Muscle Proteins
* Polymerase Chain Reaction
* Transcription Factors
* Young Adult
|keywords=* Age the living
* CpGs
* DNA methylation age
* Forensic epigenetics
* Forensic sciences
|full-text-url=https://sci-hub.do/10.1016/j.legalmed.2020.101763
}}
==EDF1==
 
{{medline-entry
|title=Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33237274
 
 
|keywords=*
          FOREVER YOUNG FLOWER
       
*
          Phalaenopsis orchids
* Abscission
* Ethylene responses
* MADS-box gene
* Senescence
|full-text-url=https://sci-hub.do/10.1093/pcp/pcaa145
}}
==EFS==
 
{{medline-entry
|title=The aging bladder phenotype is not the direct consequence of bladder aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452236
 
|mesh-terms=* Adrenergic beta-Agonists
* Aging
* Animals
* Carbachol
* Cholinergic Agonists
* Electric Stimulation
* Female
* Isoproterenol
* Male
* Mice
* Mucous Membrane
* Muscle Contraction
* Myography
* Phenotype
* Receptor, Muscarinic M3
* Receptors, Adrenergic, beta-2
* Urinary Bladder
* Urination
|keywords=* aging
* control physiology
* resilience
* urinary dysfunction
|full-text-url=https://sci-hub.do/10.1002/nau.24149
}}
==EGF==
 
{{medline-entry
|title=Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33289019
 
 
|keywords=* growth factors
* human aging
* inflammation
* physical activity
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa310
}}
{{medline-entry
|title=Proinflammation, profibrosis, and arterial aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103036
 
 
|keywords=* aging
* artery
* collagen
* profibrosis
* proinflammation
* stiffening
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574637
}}
{{medline-entry
|title=Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917321
 
 
|keywords=* Autophagy
* Epidermal growth factor
* Hinokitiol
* Senescence
* c-Jun N-Terminal kinase
|full-text-url=https://sci-hub.do/10.1016/j.tjog.2020.07.013
}}
{{medline-entry
|title=Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32323422
 
 
|keywords=* EGFR
* HUVEC
* IMR90
* Ras signaling
* pro-inflammatory cytokine
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253070
}}
{{medline-entry
|title=Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32225024
 
 
|keywords=* ISC
* fruit fly
* insulin signaling pathway
* lifespan
* metabolism
* midgut
* progenitor cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226132
}}
{{medline-entry
|title=Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001323
 
|mesh-terms=* Animals
* ErbB Receptors
* Signal Transduction
* Swine
|keywords=* Aging
* Cell behaviour
* EGF
* EGFR
* Signalling pathway
|full-text-url=https://sci-hub.do/10.1016/j.ygcen.2020.113415
}}
==EGFR==
 
{{medline-entry
|title=Type I Collagen Aging Increases Expression and Activation of [[EGFR]] and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33014812
 
 
|keywords=* EGFR
* Erlotinib
* Type I collagen
* aging
* resistance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511549
}}
{{medline-entry
|title=Comparative effectiveness and cost-effectiveness of three first-line [[EGFR]]-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267879
 
|mesh-terms=* Afatinib
* Aged
* Carcinoma, Non-Small-Cell Lung
* Cost-Benefit Analysis
* Erlotinib Hydrochloride
* Female
* Gefitinib
* Humans
* Life Expectancy
* Lung Neoplasms
* Male
* Propensity Score
* Protein Kinase Inhibitors
* Quality of Life
* Survival Rate
* Taiwan
* Tertiary Care Centers
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141611
}}
{{medline-entry
|title=An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201167
 
|mesh-terms=* Animals
* Cell Communication
* Cell Proliferation
* Cells, Cultured
* Drosophila Proteins
* Drosophila melanogaster
* Gene Expression Regulation
* Gene Regulatory Networks
* Homeostasis
* Intestinal Mucosa
* Light
* Longevity
* Optogenetics
* Signal Transduction
* Stem Cells
|keywords=* Drosophila
* EGFR
* Toll
* optogenetics
* stem cells
|full-text-url=https://sci-hub.do/10.1016/j.jmb.2020.03.019
}}
{{medline-entry
|title=Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31935369
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Animals
* Apoptosis
* Cell Cycle Proteins
* Cell Line, Tumor
* Cell Proliferation
* Cell Survival
* Cellular Senescence
* Drug Resistance, Neoplasm
* ErbB Receptors
* Female
* Gene Deletion
* Gene Expression Regulation, Neoplastic
* Humans
* Lung Neoplasms
* MAP Kinase Kinase 1
* Male
* Mice
* Mice, Knockout
* Mutation
* Signal Transduction
* Transcription Factors
* Transcription, Genetic
|keywords=* YAP
* dormancy
* drug resistance
* drug tolerance
* epidermal growth factor receptor
* lung cancer
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146079
}}
{{medline-entry
|title=Association between [[EGFR]] mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634646
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Case-Control Studies
* ErbB Receptors
* Female
* Gastroesophageal Reflux
* Humans
* Lung Neoplasms
* Male
* Middle Aged
* Mutation
* Pneumonia
* Republic of Korea
* Retrospective Studies
* Risk Factors
* Young Adult
|keywords=* Ageing
* EGFR mutation
* GERD
* Lung cancer
* Pneumonia
* Risk factors
|full-text-url=https://sci-hub.do/10.1016/j.ejca.2019.09.010
}}
==EHF==
 
{{medline-entry
|title=Extended high frequency hearing and speech perception implications in adults and children.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32111404
 
 
|keywords=* Aging
* Development
* Extended high frequency audiometry
* Otitis media
* Ototoxicity
* Speech in noise
* Speech perception
* Tinnitus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431381
}}
==EIF4E==
 
{{medline-entry
|title=Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424344
 
|mesh-terms=* Aging
* Animals
* Insulin
* Isoptera
* Molecular Sequence Annotation
* Signal Transduction
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235038
}}
==ELF3==
 
{{medline-entry
|title=High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32732458
 
 
|keywords=* Arabidopsis
* PIF4
* phytochrome
* senescence
* temperature
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398796
}}
==ELOVL2==
 
{{medline-entry
|title=[[ELOVL2]]: Not just a biomarker of aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33043173
 
 
|keywords=* Aging
* Macular degeneration
* Membrane structure
* Polyunsaturated fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544151
}}
{{medline-entry
|title=The lipid elongation enzyme [[ELOVL2]] is a molecular regulator of aging in the retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31943697
 
|mesh-terms=* Aging
* Animals
* Cell Line
* DNA Methylation
* Decitabine
* Down-Regulation
* Fatty Acid Elongases
* Fatty Acids, Unsaturated
* Female
* Humans
* Macular Degeneration
* Male
* Mice
* Mice, Transgenic
* Point Mutation
* Promoter Regions, Genetic
* Retina
* Retinal Pigment Epithelium
|keywords=* DNA methylation
* ELOVL2
* PUFA
* age-related macular degeneration
* aging
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996962
}}
==EN1==
 
{{medline-entry
|title=Electrochemically detecting DNA methylation in the [[EN1]] gene promoter: implications for understanding ageing and disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135722
 
 
|keywords=* Aging
* biosensor
* electrochemistry
* methylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670582
}}
==ENO1==
 
{{medline-entry
|title=Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32355541
 
 
|keywords=* ENO1
* Enolase
* beta-Gal
* cisplatin resistance
* glucose
* ovarian cancer
* p21
* p53
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191177
}}
==ENTPD7==
 
{{medline-entry
|title=Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 ([[ENTPD7]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443651
 
|mesh-terms=* Adult
* Aged
* Animals
* Apoptosis
* Apyrase
* Biomarkers
* Cell Line, Tumor
* Cell Proliferation
* Cells, Cultured
* Female
* Gene Expression Regulation, Neoplastic
* Gene Silencing
* Humans
* Lung Neoplasms
* MAP Kinase Signaling System
* Male
* Mice
* Mice, Inbred BALB C
* Mice, Nude
* Middle Aged
* Mitogen-Activated Protein Kinases
* Plasmids
* Signal Transduction
* Survival Analysis
* raf Kinases
* ras Proteins
|keywords=* Ectonucleoside triphosphate phosphohydrolase-7
* Lung cancer
* Proliferation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708200
}}
==EPO==
 
{{medline-entry
|title=Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32029230
 
 
|keywords=* Aging
* Brain
* Erythropoietin
* Glucose tolerance
* Hypothalamus
* Metabolism
* Muscle
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938905
}}
{{medline-entry
|title=Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31550724
 
|mesh-terms=* Anemia
* Erythrocytes
* Female
* Humans
* Male
* Middle Aged
* Renal Insufficiency, Chronic
|keywords=* Chronic kidney disease
* Erythropoietin
* Levitt’s CO breath test
* Red blood cell lifespan
* Renal anemia
|full-text-url=https://sci-hub.do/10.1159/000502525
}}
==ERCC1==
 
{{medline-entry
|title=Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630010
 
 
|keywords=* aging
* cGMP
* guanylate cyclase
* hypertension
* nitric oxide
* phosphodiesterase
* sildenafil
* vascular dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369923
}}
{{medline-entry
|title=Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32202295
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Capillary Permeability
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* DNA Damage
* DNA Repair
* DNA-Binding Proteins
* Endonucleases
* Endothelial Cells
* Endothelium, Vascular
* Mice, Inbred C57BL
* Mice, Knockout
* Nitric Oxide
* Nitric Oxide Synthase Type III
* Superoxides
* Vascular Stiffness
* Vasodilation
|keywords=* DNA damage
* aging
* endothelial dysfunction
* endothelium-dependent dilation
* nitric oxide
|full-text-url=https://sci-hub.do/10.1042/CS20190124
}}
{{medline-entry
|title=Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31981461
 
 
|keywords=* DNA repair
* ERCC1-XPF
* aging
* cellular senescence
* endogenous DNA damage
* progeria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059165
}}
{{medline-entry
|title=Deficiency in the DNA repair protein [[ERCC1]] triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737985
 
 
|keywords=* DNA damage repair
* aging
* cell death
* senescence-associated secretory phenotype
* tumor necrosis factor α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059167
}}
==ERF==
 
{{medline-entry
|title=Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041838
 
 
|keywords=* ACE D/I gene polymorphism
* Chinese women
* aging
* endothelial function
* endothelial-released factors
* menopause
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526498
}}
{{medline-entry
|title=Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32542573
 
 
|keywords=* Air pollution
* Climate change
* Mortality
* Population aging
* Projection
* Temperature
|full-text-url=https://sci-hub.do/10.1007/s40572-020-00281-6
}}
{{medline-entry
|title=Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32425970
 
 
|keywords=* ATM
* RPL8
* aging
* meta-analysis
* telomere
* whole exome sequencing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204400
}}
==ERG==
 
{{medline-entry
|title=Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882213
 
 
|keywords=* Aging
* Electroretinography
* Neurodegeneration
* Neurodevelopment
* Optical coherence tomography
* Retina
* Sex
|full-text-url=https://sci-hub.do/10.1016/j.exer.2020.108208
}}
{{medline-entry
|title=Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31487745
 
|mesh-terms=* Aging
* Animals
* Biomarkers
* Electroretinography
* Enzyme-Linked Immunosorbent Assay
* Immunohistochemistry
* Malondialdehyde
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Microscopy, Electron, Transmission
* Mitochondria
* Oxidative Stress
* Protein Deglycase DJ-1
* Retina
* Retinal Degeneration
* Retinal Pigment Epithelium
* Superoxide Dismutase-1
* Tomography, Optical Coherence
* Ubiquitin-Protein Ligases
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733419
}}
==ESPL1==
 
{{medline-entry
|title=Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32574725
 
 
|keywords=* Genomics
* Longevity
* Pedigree
* Rare variant sharing
* Utah population database
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461696
}}
==ETS1==
 
{{medline-entry
|title=The transcription factor [[ETS1]] promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31659122
 
|mesh-terms=* ATP Binding Cassette Transporter, Subfamily B
* Animals
* Apoptosis
* Cellular Senescence
* Hepatocytes
* Humans
* Lipopolysaccharides
* Liver
* Mice
* Proto-Oncogene Protein c-ets-1
* Transcription Factors
* bcl-X Protein
|keywords=* BCL2 like 1 (BCL2L1)
* apoptosis
* cholangiocyte
* chromatin modification
* epigenetics
* gene expression
* primary sclerosing cholangitis (PSC)
* senescence
* transcription factor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901313
}}
==EVL==
 
{{medline-entry
|title=Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31952678
 
|mesh-terms=* Cost-Benefit Analysis
* Health Care Costs
* Health Status
* Health Status Indicators
* Humans
* Life Expectancy
* Quality of Life
* Quality-Adjusted Life Years
* Time Factors
|keywords=* cost-effectiveness
* equal value of life
* health years in total
* quality-adjusted life-year
* thresholds
|full-text-url=https://sci-hub.do/10.1016/j.jval.2019.10.014
}}
==EZH2==
 
{{medline-entry
|title=Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32729176
 
 
|keywords=* Cetacea
* aging
* bone
* hyperostosis
* osteoblasts
* whales
|full-text-url=https://sci-hub.do/10.1002/jez.b.22990
}}
{{medline-entry
|title=[[EZH2]] is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32553389
 
 
|keywords=* Aging
* CUMS
* Cytokines
* Depresion
* EZH2
* Microglia
|full-text-url=https://sci-hub.do/10.1016/j.jad.2020.03.154
}}
{{medline-entry
|title=A positive feedback loop between [[EZH2]] and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025238
 
 
|keywords=* Epigenetic histone modification
* Intervertebral disc degeneration
* Nucleus pulposus cell senescence
* Wnt/β-catenin signaling pathway
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995653
}}
{{medline-entry
|title=Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917966
 
|mesh-terms=* Actins
* Aging
* Animals
* Benzhydryl Compounds
* Cell Proliferation
* Collagen
* Enhancer of Zeste Homolog 2 Protein
* Female
* Gerbillinae
* Histones
* Mammary Glands, Animal
* Phenols
* Pregnancy
* Prenatal Exposure Delayed Effects
|keywords=* BPA
* EZH2
* Environment pollutant
* Estrogen
* Morphologic alterations
* Phospho-histone-h3
|full-text-url=https://sci-hub.do/10.1016/j.yexmp.2020.104374
}}
==F2==
 
{{medline-entry
|title=Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33189381
 
 
|keywords=* Glufosinate resistance
* Relative fitness
* Seed longevity
* Transgene flow
* Weed risk
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.143073
}}
{{medline-entry
|title=Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and [[F2]] offspring via different pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010264
 
 
|keywords=* Arsenic
* Liver
* Multigenerational Effect
* SASP
* Senescence
* Tumor
|full-text-url=https://sci-hub.do/10.1016/j.taap.2020.115259
}}
{{medline-entry
|title=Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32303766
 
 
|keywords=* Thyroid
* longevity
* recombinant human TSH
* responsivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239378
}}
{{medline-entry
|title=Conclusions from a behavioral aging study on male and female [[F2]] hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31509518
 
|mesh-terms=* Adiposity
* Aging
* Animals
* Exploratory Behavior
* Female
* Male
* Memory
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Swimming
|keywords=* F2 hybrid mice
* aging
* exploratory activity
* sex comparison
* water-based behavioral tests
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756906
}}
{{medline-entry
|title=In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428698
 
|mesh-terms=* Acetaminophen
* Aging
* Animals
* Animals, Newborn
* Cell Proliferation
* Female
* Fertility
* Forkhead Box Protein O3
* Germ Cells
* Ibuprofen
* Luteolysis
* Mice
* Ovary
* Pregnancy
* Prenatal Exposure Delayed Effects
* Proto-Oncogene Proteins c-akt
* Reproduction
* Signal Transduction
|keywords=* Infertility
* Oogenesis
* Risk factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692356
}}
==F3==
 
{{medline-entry
|title=A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33293174
 
 
|keywords=* Acoustic
* Aging voice
* European Portuguese
* Oral vowel
|full-text-url=https://sci-hub.do/10.1016/j.jvoice.2020.10.021
}}
{{medline-entry
|title=Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129917
 
 
|keywords=* cyclicity
* hormone
* mixture
* ovary
* phthalates
* reproductive aging
* transgenerational
|full-text-url=https://sci-hub.do/10.1016/j.reprotox.2020.10.009
}}
{{medline-entry
|title=Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32808403
 
 
|keywords=* Aging
* cognition
* rehabilitation
* transcranial direct current stimulation
* walking
|full-text-url=https://sci-hub.do/10.1111/ner.13250
}}
{{medline-entry
|title=Multigenerational exposure to TiO  nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203849
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Insulin
* Longevity
* Nanoparticles
* Oxidative Stress
* Soil
* Titanium
|keywords=* Insulin/IGF-like signaling
* Longevity
* Multigenerational toxicity
* Nanomaterial
* Soil nematode
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.114376
}}
{{medline-entry
|title=Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514170
 
|mesh-terms=* Aging
* Animals
* Fatty Acids, Nonesterified
* Gene Expression Profiling
* Gene Expression Regulation
* Gene Regulatory Networks
* Lipid Metabolism
* Mice
* Microarray Analysis
* Signal Transduction
* Triglycerides
* Vascular Diseases
|keywords=* aging
* co-expression network
* hub gene
* module
* mouse
* vascular dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781998
}}
==F5==
 
{{medline-entry
|title=Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039401
 
 
|keywords=* ALP, alkaline phosphatase
* ALT, alanine aminotransferase
* Aging
* BMI, body mass index
* DNAm, DNA methylation
* ELF, enhanced liver fibrosis
* FDR, false discovery rate
* GGT, gamma-glutamyltransferase
* IBD, inflammatory bowel disease
* IL, interleukin
* LOXL2, lysyl oxidase-like-2
* NASH, non-alcoholic steatohepatitis
* PSC, primary sclerosing cholangitis
* SMA, smooth muscle actin
* UDCA, ursodeoxycholic acid
* biomarker
* inflammatory bowel disease
* primary sclerosing cholangitis
* prognosis
* ursodeoxycholic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005566
}}
{{medline-entry
|title=Fermentation of Blackberry with [i]L. plantarum[/i] JBMI [[F5]] Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31614689
 
|mesh-terms=* Animals
* Cell Line
* Cell Survival
* Female
* Fermentation
* Fibroblasts
* Foreskin
* Fruit
* Lactobacillus plantarum
* Male
* Mice
* Mice, Hairless
* Plant Extracts
* Rubus
* Skin Aging
* Ultraviolet Rays
|keywords=* Lactobacillus plantarum
* MMPs
* fermented blackberry
* photoaging
* skin aging
* type I procollagen
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835613
}}
==F7==
 
{{medline-entry
|title=The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524160
 
|mesh-terms=* Aged
* Aging
* Cognitive Dysfunction
* Electroencephalography
* Emotions
* Female
* Frontal Lobe
* Humans
* Male
* Memory
* Neurophysiological Monitoring
* Neuropsychological Tests
* Task Performance and Analysis
* Temporal Lobe
|keywords=* Emotional destination memory
* Mu suppression
* fronto-temporal
* mild cognitive impairment
* mirror neurons
|full-text-url=https://sci-hub.do/10.3233/JAD-190311
}}
==FAAH==
 
{{medline-entry
|title=Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32095523
 
|mesh-terms=* Aging
* Amidohydrolases
* Animals
* Axons
* Choice Behavior
* Dronabinol
* Endocannabinoids
* Female
* Genetic Variation
* Male
* Mice, Inbred C57BL
* Nerve Net
* Nucleus Accumbens
* Polymorphism, Single Nucleotide
* Receptor, Cannabinoid, CB1
* Reward
* Tyrosine 3-Monooxygenase
* Ventral Tegmental Area
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015690
}}
==FABP3==
 
{{medline-entry
|title=[[FABP3]]-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168829
 
|mesh-terms=* Aging
* Animals
* Cell Line
* Endoplasmic Reticulum Stress
* Eukaryotic Initiation Factor-2
* Fatty Acid Binding Protein 3
* Female
* Gene Knockdown Techniques
* Lipidomics
* Membrane Fluidity
* Membrane Lipids
* Mice, Inbred C57BL
* Mice, Knockout
* Muscle, Skeletal
* Myoblasts
* Phospholipids
* Protein-Serine-Threonine Kinases
* Sarcopenia
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653047
}}
{{medline-entry
|title=Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing [[FABP3]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143524
 
 
|keywords=* Adipogenesis
* autophagy
* bone metabolism
* fabp3
* mesenchymal stem cell
* optineurin
* osteogenesis
* osteoporosis
* senescence
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1839286
}}
{{medline-entry
|title=Myokines as biomarkers of frailty and cardiovascular disease risk in females.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32017952
 
 
|keywords=* Aging
* Biomarkers
* Cardiovascular disease
* Females
* Frailty
* Myokines
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110859
}}
==FADS1==
 
{{medline-entry
|title=Aging and [[FADS1]] polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31492428
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Alleles
* Arachidonic Acid
* Area Under Curve
* Fatty Acid Desaturases
* Fatty Acids, Unsaturated
* Female
* Healthy Volunteers
* Humans
* Linoleic Acid
* Male
* Polymorphism, Single Nucleotide
|keywords=* Aging
* Arachidonic acid
* Fatty acid conversion
* Linoleic acid
* Lipid metabolism
* Long-chain polyunsaturated fatty acid
|full-text-url=https://sci-hub.do/10.1016/j.plefa.2019.07.003
}}
==FANCD2==
 
{{medline-entry
|title=TFG-maintaining stability of overlooked [[FANCD2]] confers early DNA-damage response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099537
 
 
|keywords=* DNA damage response
* FANCD2
* TFG
* aging and cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655164
}}
==FAP==
 
{{medline-entry
|title=Rapamycin Extends Life Span in Apc  Colon Cancer [[FAP]] Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132009
 
 
|keywords=* Aging
* Crypt stem cells
* eEF2K
* mTORC1
* rpS6
|full-text-url=https://sci-hub.do/10.1016/j.clcc.2020.08.006
}}
{{medline-entry
|title=Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32060352
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Exercise Therapy
* Female
* Humans
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Muscle, Skeletal
* Muscular Diseases
* Regeneration
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021787
}}
{{medline-entry
|title=Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31865646
 
|mesh-terms=* Adipogenesis
* Adolescent
* Adult
* Adult Stem Cells
* Aged
* Aging
* Cells, Cultured
* Child
* Child, Preschool
* Female
* Humans
* Infant
* Male
* Middle Aged
* Muscle Development
* Muscular Dystrophy, Duchenne
* Myoblasts
* Young Adult
|keywords=Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies
|full-text-url=https://sci-hub.do/10.33594/000000196
}}
==FAS==
 
{{medline-entry
|title=Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32952883
 
 
|keywords=* Aging
* Biological age
* Elderly
* Physical function
* Tongue pressure
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486543
}}
{{medline-entry
|title=Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064756
 
 
|keywords=* MDM2
* Senescence
* USP7
* apoptosis
* p53
* senolytics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059172
}}
==FES==
 
{{medline-entry
|title=An outpatient Tai Chi program: Effects on veterans' functional outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33241873
 
 
|keywords=* Tai Chi
* balance
* exercise
* gait
* geriatrics
|full-text-url=https://sci-hub.do/10.1111/nuf.12532
}}
{{medline-entry
|title=Gait Function in Adults Aged 50 Years and Older With Spina Bifida.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166524
 
 
|keywords=* Adult
* Aging
* Gait analysis
* Myelomeningocele
* Rehabilitation
|full-text-url=https://sci-hub.do/10.1016/j.apmr.2020.10.118
}}
{{medline-entry
|title=A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32165062
 
 
|keywords=* FES-I
* elderly
* fear of falling
* healthy aging
* older adults
|full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.01.101
}}
{{medline-entry
|title=Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31664911
 
|mesh-terms=* Accidental Falls
* Activities of Daily Living
* Aged
* Aging
* Female
* Geriatric Assessment
* Humans
* Independent Living
* Japan
* Longitudinal Studies
* Male
* Physical Functional Performance
* Postural Balance
* Risk Factors
* Walking Speed
|keywords=* Accidental falls
* Aged
* Fall-related efficacy
* Japanese
* Physical performance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820944
}}
{{medline-entry
|title=Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514583
 
|mesh-terms=* Accidental Falls
* Aged
* Aging
* Brain
* Electroencephalography
* Fear
* Female
* Humans
* Male
* Movement
* Postural Balance
* Posture
 
|full-text-url=https://sci-hub.do/10.1080/0361073X.2019.1664450
}}
==FEV==
 
{{medline-entry
|title=Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33182250
 
 
|keywords=* epigenetic aging
* feature selection
* hyperparameter tuning
* lung function
* machine learning
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712054
}}
{{medline-entry
|title=Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33031829
 
 
|keywords=* COPD
* aging
* exacerbations
* safety
* single-inhaler triple therapy
|full-text-url=https://sci-hub.do/10.1016/j.chest.2020.09.253
}}
{{medline-entry
|title=A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010732
 
 
|keywords=* Aging
* Determinants
* Lung function
* Sex
* Spirometry
|full-text-url=https://sci-hub.do/10.1016/j.rmed.2020.106157
}}
{{medline-entry
|title=Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517728
 
 
|keywords=* Aging
* COPD
* Klotho
* Pulmonary emphysema
* Risk factors
* Telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285611
}}
{{medline-entry
|title=Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32320797
 
 
|keywords=* Aging
* Asthma
* Long-acting muscarinic antagonist
* Long-acting β(2)-agonists
* Pharmacotherapy
|full-text-url=https://sci-hub.do/10.1016/j.jaip.2020.04.013
}}
{{medline-entry
|title=Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32071132
 
 
|keywords=* aging
* albuterol
* asthma
* bronchodilator effect
* lung diseases
* older adult
* spirometry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538007
}}
{{medline-entry
|title=Physical performances show conflicting associations in aged manual workers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32042126
 
|mesh-terms=* Aged
* Aging
* Body Composition
* Body Mass Index
* Cardiorespiratory Fitness
* Cross-Sectional Studies
* Hand Strength
* Humans
* Lung
* Male
* Middle Aged
* Physical Functional Performance
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010773
}}
{{medline-entry
|title=[[FEV]]  as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31662447
 
 
|keywords=* aging
* average attributable fraction
* death
* relative risk
* spirometry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055488
}}
{{medline-entry
|title=An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31542453
 
|mesh-terms=* Adult
* Age Factors
* Aging
* Alcohol Drinking
* Algorithms
* Alkaline Phosphatase
* Body Height
* Bronchodilator Agents
* Cigarette Smoking
* Cohort Studies
* Cough
* Dyspnea
* Electrocardiography
* Female
* Forced Expiratory Volume
* Hematocrit
* Humans
* Leukocyte Count
* Longitudinal Studies
* Lung
* Machine Learning
* Male
* Middle Aged
* Pulmonary Disease, Chronic Obstructive
* Risk Assessment
* Serum Albumin
* Serum Globulins
* Sex Factors
* Spirometry
* Triglycerides
* Vital Capacity
|keywords=* COPD
* FEV(1)
* FEV(1)/FVC
* airflow limitation
* lung function
* predictive modeling
|full-text-url=https://sci-hub.do/10.1016/j.chest.2019.09.003
}}
{{medline-entry
|title=Telomere length and lung function in a population-based cohort of children and mid-life adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31456360
 
|mesh-terms=* Aged
* Asthma
* Body Mass Index
* Child
* Cohort Studies
* Cross-Sectional Studies
* Exercise
* Female
* Forced Expiratory Volume
* Humans
* Lung
* Male
* Respiratory Function Tests
* Risk Factors
* Smoking
* Spirometry
* Telomere
* Vital Capacity
|keywords=* aging
* cell senescence
* life course
* national cohort
* spirometry
|full-text-url=https://sci-hub.do/10.1002/ppul.24489
}}
==FGA==
 
{{medline-entry
|title=Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31718416
 
|mesh-terms=* Adaptation, Psychological
* Aged
* Aging
* Depression
* Disabled Persons
* Female
* Goals
* Humans
* Male
* Middle Aged
* Multiple Sclerosis
* Muscular Dystrophies
* Pain
* Postpoliomyelitis Syndrome
* Spinal Cord Injuries
|keywords=* aging
* disability
* goal management
* pain
* psychological adaptation
|full-text-url=https://sci-hub.do/10.1177/0898264319827142
}}
{{medline-entry
|title=Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547780
 
 
|keywords=* flexible goal adjustment
* life satisfaction
* older couples
* self-perceptions of aging
* tenacious goal pursuit
|full-text-url=https://sci-hub.do/10.1177/0164027519876125
}}
==FGF19==
 
{{medline-entry
|title=Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32123836
 
 
|keywords=* FGF19
* FXR
* TGR5
* autoimmunity
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996327
}}
==FGF2==
 
{{medline-entry
|title=The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840944
 
 
|keywords=* cell proliferation
* cellular senescence
* fibroblast growth factor 2
* long-term culture
* mesenchymal stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103622
}}
==FGF21==
 
{{medline-entry
|title=Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33106871
 
 
|keywords=* Clostridales
* firmicutes
* lifespan
* methionine restriction
* sulfur metabolism
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa270
}}
{{medline-entry
|title=Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32911033
 
 
|keywords=* Accelerometer
* Activity intensity
* Aging
* FGF21
* Physical activity
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111081
}}
{{medline-entry
|title=Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863214
 
 
|keywords=* Aging
* Exercise
* FGF21
* Lipophagy
* Nonalcoholic fatty liver disease (NAFLD)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365984
}}
{{medline-entry
|title=Mitochondria, immunosenescence and inflammaging: a role for mitokines?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32757036
 
 
|keywords=* Human ageing
* Immunosenescence
* Inflammaging
* Mitochondrial metabolism
* Mitokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666292
}}
{{medline-entry
|title=Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573078
 
 
|keywords=* ER stress
* cysteine
* glutathione
* hormesis
* lifespan
* methionine
* trade-offs
* translational
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426777
}}
{{medline-entry
|title=Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32309367
 
 
|keywords=* Bombyx mori
* fibroblast growth factor 21 (FGF21)
* lifespan
* oxidation resistance
* stress tolerance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154471
}}
{{medline-entry
|title=Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31723038
 
|mesh-terms=* Animals
* Butyrates
* Fecal Microbiota Transplantation
* Fibroblast Growth Factors
* Gastrointestinal Microbiome
* Germ-Free Life
* Hippocampus
* Intestines
* Liver
* Longevity
* Male
* Metabolome
* Mice, Inbred C57BL
* Microtubule-Associated Proteins
* Neurogenesis
* Neurons
* Neuropeptides
* Phenotype
* Proton Magnetic Resonance Spectroscopy
 
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.aau4760
}}
{{medline-entry
|title=Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31490857
 
|mesh-terms=* Adiponectin
* Adult
* Aging
* Blood Glucose
* Blood Pressure
* Body Mass Index
* Diabetes Mellitus, Type 2
* Exercise
* Female
* Fibroblast Growth Factors
* Glucose Tolerance Test
* Humans
* Insulin
* Lipids
* Male
* Middle Aged
* Risk Factors
 
|full-text-url=https://sci-hub.do/10.1249/MSS.0000000000002150
}}
{{medline-entry
|title=Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31405194
 
|mesh-terms=* Adiposity
* Aging
* Animals
* Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
* Blood Glucose
* Diet, Fat-Restricted
* Dietary Fats
* Disease Models, Animal
* Dyslipidemias
* Glucagon
* Insulin
* Lipids
* Liver
* Metabolic Syndrome
* Postprandial Period
* Rats
* Rats, Wistar
* Triglycerides
|keywords=* ChREBP
* adipose tissue
* ageing
* oral lipid loading test
* postprandial hypertrigliceridemia
* postprandial thermogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723802
}}
==FGF23==
 
{{medline-entry
|title=Phosphate as a Pathogen of Arteriosclerosis and Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33028781
 
 
|keywords=* Aging
* Calciprotein particles (CPPs)
* Fibroblast growth factor-23 (FGF23)
* Inflammation
* Klotho
* Phosphate
* Vascular calcification
|full-text-url=https://sci-hub.do/10.5551/jat.RV17045
}}
{{medline-entry
|title=Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32405607
 
 
|keywords=* aging
* chronic kidney disease
* fibroblast growth factor 23
* mobility disability
* αKlotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209777
}}
{{medline-entry
|title=Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32042011
 
|mesh-terms=* Aging
* Animals
* Calcium
* Dietary Carbohydrates
* Fibroblast Growth Factors
* Galactose
* Glucuronidase
* Male
* Oxidative Stress
* Phosphorus
* Phytochemicals
* Polygonatum
* Polysaccharides
* Protective Agents
* Rats
* Rats, Sprague-Dawley
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010663
}}
{{medline-entry
|title=[[FGF23]] expression is stimulated in transgenic α-Klotho longevity mouse model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801907
 
|mesh-terms=* Aldosterone
* Animals
* Bone and Bones
* Cardiovascular Diseases
* Disease Models, Animal
* Female
* Fibroblast Growth Factors
* Gene Knockout Techniques
* Glucuronidase
* Kidney
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Osteoblasts
* Protein Isoforms
* Transcriptome
|keywords=* Bone Biology
* Cardiovascular disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962016
}}
{{medline-entry
|title=Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31568615
 
|mesh-terms=* Aging
* Animals
* Arginine
* Biomarkers
* Cats
* Cross-Sectional Studies
* Female
* Fibroblast Growth Factors
* Male
* Reference Values
* Retrospective Moral Judgment
|keywords=* azotemia
* feline
* phosphate
* renal
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872607
}}
==FGFR1==
 
{{medline-entry
|title=Alignment of Alzheimer's disease amyloid β-peptide and klotho.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999998
 
 
|keywords=* Alzheimer’s disease
* HSV-1
* aging
* alignment
* klotho
* neurodegeneration
* neuroinflammation
* protein
* ubiquitin
* β-amyloid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521834
}}
{{medline-entry
|title=Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103583
 
 
|keywords=* Cdon
* Cellular senescence
* FGFR
* Growth factor signalling
* Muscle regeneration
* Satellite cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432598
}}
==FGFR4==
 
{{medline-entry
|title=[[FGFR4]] Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066597
 
 
|keywords=* FGFR4
* FGFR4 inhibitor
* growth
* invasion
* pancreatic cancer
* senescence
* senolytic therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602396
}}
==FGR==
 
{{medline-entry
|title=Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452402
 
 
|keywords=* Aurora kinase
* Cellular senescence
* FGR
* Preeclampsia
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.04.012
}}
==FH==
 
{{medline-entry
|title=Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252089
 
 
|keywords=* APOE4
* Aging
* Mediterranean diet
* cognitive decline
* functional food
* lamb
* nutrition policy
* preventive medicine
* red wine
* salt
|full-text-url=https://sci-hub.do/10.3233/JAD-201058
}}
{{medline-entry
|title=Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311609
 
|mesh-terms=* Adult
* Aging
* Alzheimer Disease
* Apolipoproteins E
* Atrophy
* Dementia
* Diffusion Magnetic Resonance Imaging
* Educational Status
* Female
* Genotype
* Hippocampus
* Humans
* Male
* Middle Aged
* Organ Size
* Risk
|keywords=* Alzheimer's disease
* Dementia
* Hippocampal subfields
* Hippocampus
* Preclinical dementia
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.006
}}
{{medline-entry
|title=Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32118768
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cross-Sectional Studies
* Female
* Hematuria
* Hemophilia A
* Humans
* Hypertension
* Israel
* Logistic Models
* Male
* Middle Aged
* Risk Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478422
}}
{{medline-entry
|title=LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815695
 
|mesh-terms=* Aging
* Amyloid beta-Protein Precursor
* Animals
* Apoptosis
* Brain Chemistry
* Caspase 3
* Cholesterol
* Gene Expression
* Hippocampus
* Male
* Maze Learning
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Prefrontal Cortex
* Receptors, LDL
|keywords=* Familial hypercholesterolemia
* LDLr-/- mice
* amyloid-β
* apoptosis
* memory impairment
|full-text-url=https://sci-hub.do/10.3233/JAD-190742
}}
==FNDC5==
 
{{medline-entry
|title=Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33053231
 
 
|keywords=* BONE-MUSCLE INTERACTIONS
* IRISIN
* OSTEOPOROSIS
* SARCOPENIA
* SENESCENCE
|full-text-url=https://sci-hub.do/10.1002/jbmr.4192
}}
{{medline-entry
|title=[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512422
 
|mesh-terms=* Aged
* Aging
* Biomarkers
* Cytokines
* Humans
* Middle Aged
* Myocardial Infarction
* Saliva
* Tumor Necrosis Factor-alpha
|keywords=* aging
* diagnosis
* myocardial infarction
* saliva
* signaling molecules
 
}}
==FOS==
 
{{medline-entry
|title=Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233025
 
 
|keywords=* HIF-1α-AS2
* aging
* lncRNAs
* miR-29b-3p
* muscle atrophy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253071
}}
==FOSL2==
 
{{medline-entry
|title=LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32149459
 
 
|keywords=*
GUARDIN
 
* LRP130-PGC1α
* cellular senescence
* lncRNAs
* p21
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132339
}}
==FOXA1==
 
{{medline-entry
|title=Analyses of an epigenetic switch involved in the activation of pioneer factor [[FOXA1]] leading to the prognostic value of estrogen receptor and [[FOXA1]] co-expression in breast cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562808
 
|mesh-terms=* Breast Neoplasms
* Down-Regulation
* Epigenesis, Genetic
* Female
* Gene Expression Regulation, Neoplastic
* Hepatocyte Nuclear Factor 3-alpha
* Humans
* Middle Aged
* Prognosis
* RNA, Messenger
* Receptor, ErbB-2
* Receptors, Estrogen
* Receptors, Progesterone
* Transcriptome
* Up-Regulation
|keywords=* FOXA1
* age-related diseases
* aging
* breast cancer
* hormone receptor
* methylation
* prognosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782010
}}
==FOXM1==
 
{{medline-entry
|title=Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171439
 
 
|keywords=* FOXM1
* SIRT6
* cell cycle
* endothelial cell
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695388
}}
==FOXN1==
 
{{medline-entry
|title=Thymic rejuvenation via [[FOXN1]]-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32790650
 
 
|keywords=* Aging
* Immunology
* Immunotherapy
* T cell development
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526556
}}
==FOXO1==
 
{{medline-entry
|title=l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31899338
 
 
|keywords=* AGEs
* Inflammatory response
* Liver aging
* Oxidative stress
* l-Theanine
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110823
}}
==FOXO3==
 
{{medline-entry
|title=The DNA methylation of [[FOXO3]] and TP53 as a blood biomarker of late-onset asthma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33298101
 
 
|keywords=* Aging
* DNA methylation
* FOXO3
* Late-onset asthma
* TP53
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726856
}}
{{medline-entry
|title=[[FOXO3]] targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16  increase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33156570
 
 
|keywords=* neurodegenerative disease
* neuronal differentiation
* neuronal senescence
* response mechanisms
* temporal dynamics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681055
}}
{{medline-entry
|title=Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32635607
 
 
|keywords=* FOXO3
* NRF2
* SIRT1
* astaxanthin
* geroprotector
* longevity
* neuroprotection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401246
}}
{{medline-entry
|title=Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32340146
 
 
|keywords=* IL6
* IL6R
* aging
* cachexia
* miR-21
* microRNA
* muscle
* regeneration
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222422
}}
{{medline-entry
|title=Variable DNA methylation of aging-related genes is associated with male COPD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31684967
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Case-Control Studies
* CpG Islands
* DNA Methylation
* Databases, Genetic
* Female
* Forced Expiratory Volume
* Forkhead Transcription Factors
* Genetic Predisposition to Disease
* Humans
* Lung
* Male
* Middle Aged
* Pulmonary Disease, Chronic Obstructive
* Risk Assessment
* Risk Factors
* Severity of Illness Index
* Sex Factors
* Transcriptome
* Vital Capacity
* Young Adult
|keywords=* Aging
* Aging-related genes
* COPD
* DNA methylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829949
}}
{{medline-entry
|title=A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31415568
 
|mesh-terms=* Animals
* Animals, Genetically Modified
* Cohort Studies
* Disease Models, Animal
* Drosophila melanogaster
* Feeding Behavior
* Female
* Gene Knockdown Techniques
* Gout
* Humans
* Insulin
* Kidney Calculi
* Longevity
* Male
* Metabolic Networks and Pathways
* Middle Aged
* NADPH Oxidases
* Polymorphism, Single Nucleotide
* Purines
* Signal Transduction
* Urate Oxidase
* Uric Acid
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695094
}}
==FOXO4==
 
{{medline-entry
|title=[[FOXO4]]-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31959736
 
 
|keywords=* FOXO4-DRI
* Leydig cell
* male late-onset hypogonadism
* senescence
* senolytics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053614
}}
==FOXP1==
 
{{medline-entry
|title=GATA6 regulates aging of human mesenchymal stem/stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252174
 
 
|keywords=* aging
* cell signaling
* mesenchymal stem cells
* reprogramming
* transcription factors
|full-text-url=https://sci-hub.do/10.1002/stem.3297
}}
==FSHR==
 
{{medline-entry
|title=[[FSHR]] ablation induces depression-like behaviors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203083
 
 
|keywords=* FSH
* ROS
* aging
* antioxidants
* depression
* metabolism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468367
}}
{{medline-entry
|title=Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681968
 
|mesh-terms=* Aging
* Female
* Gonadotropin-Releasing Hormone
* Gonadotropins
* Humans
* Hypothalamo-Hypophyseal System
* Luteinizing Hormone
* Male
* Receptors, FSH
* Receptors, LH
|keywords=* aging
* folitropin
* lutropin
* neoplasia
|full-text-url=https://sci-hub.do/10.5603/EP.a2019.0034
}}
==FTO==
 
{{medline-entry
|title=Decreased expression of m A demethylase [[FTO]] in ovarian aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221958
 
 
|keywords=* Epigenetics
* FTO
* Ovarian aging
* Ovarian reserve
* m6A
|full-text-url=https://sci-hub.do/10.1007/s00404-020-05895-7
}}
==FYN==
 
{{medline-entry
|title=An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781064
 
|mesh-terms=* Animals
* Cardiomyopathies
* Cellular Senescence
* Echocardiography
* Gene Silencing
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Myocardial Infarction
* Myocardium
* Myocytes, Cardiac
* NF-E2-Related Factor 2
* RNA, Small Interfering
* Ventricular Remodeling
|keywords=* Cellular senescence
* Myocardial infarction
* Nrf2
* Oxidative stress
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118199
}}
==G6PD==
 
{{medline-entry
|title=[[G6PD]] overexpression protects from oxidative stress and age-related hearing loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33222382
 
 
|keywords=* ARHL
* NADPH
* TrxR
* aging
* glutathione
|full-text-url=https://sci-hub.do/10.1111/acel.13275
}}
{{medline-entry
|title=The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32923278
 
 
|keywords=* diabetes
* genetics
* glycosylated hemoglobin
* hba1c
* hbas
* race
* rbc lifespan
* sickle cell trait
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486097
}}
{{medline-entry
|title=DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581069
 
|mesh-terms=* Animals
* Brain
* DNA Breaks, Double-Stranded
* DNA Breaks, Single-Stranded
* DNA Damage
* Disease Models, Animal
* Enzyme Activation
* Female
* Glucosephosphate Dehydrogenase
* Glucosephosphate Dehydrogenase Deficiency
* Male
* Mental Disorders
* Mice
* Oxidation-Reduction
* Purkinje Cells
|keywords=* 8-Oxo-2′-deoxyguanine (8-oxodG)
* Aging
* Behavioural disorders
* Comet
* DNA damage
* Electrophysiology
* Gamma-H2AX (γH2AX)
* Glucose-6-phosphate dehydrogenase (G6PD)
* Lifespan
* Neurodegeneration
* Reactive oxygen species (ROS)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812046
}}
==GAA==
 
{{medline-entry
|title=Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32586831
 
 
|keywords=* Frataxin
* Friedreich's ataxia
* Mitochondria
* Oxidative stress
* Point mutation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406325
}}
{{medline-entry
|title=Age-Related Changes in Serum Guanidinoacetic Acid in Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647299
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Biomarkers
* Energy Metabolism
* Exercise
* Female
* Glycine
* Humans
* Independent Living
* Middle Aged
* Young Adult
 
|full-text-url=https://sci-hub.do/10.33549/physiolres.934189
}}
==GABARAP==
 
{{medline-entry
|title=Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32811819
 
|mesh-terms=* Adipocytes
* Adipogenesis
* Adipose Tissue
* Adiposity
* Aging
* Animals
* Apoptosis Regulatory Proteins
* Autophagy
* Fatty Liver
* Gene Knockout Techniques
* Glucose
* HEK293 Cells
* Humans
* Intracellular Signaling Peptides and Proteins
* Lipid Metabolism
* Metabolic Diseases
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Microtubule-Associated Proteins
* Nuclear Receptor Coactivator 1
* Nuclear Receptor Coactivator 2
* PPAR gamma
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434891
}}
==GAL==
 
{{medline-entry
|title=Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783149
 
 
|keywords=* Osteoarthritis
* Pitx1
* Senescence
* Sirt1
|full-text-url=https://sci-hub.do/10.1016/j.bone.2019.115177
}}
{{medline-entry
|title=β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31663807
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* DNA Damage
* Disease Models, Animal
* Galactose
* Glial Fibrillary Acidic Protein
* Hippocampus
* Male
* Mice
* Mice, Inbred BALB C
* Neuroprotection
* Oxidative Stress
* Polycyclic Sesquiterpenes
* Prefrontal Cortex
|keywords=* CB2 receptor agonist
* biological aging
* cognitive flexibility
* phytocannabinoid
* β-caryophyllene
|full-text-url=https://sci-hub.do/10.1089/jmf.2019.0111
}}
==GAP43==
 
{{medline-entry
|title=HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171589
 
|mesh-terms=* Aging
* Animals
* Axons
* GAP-43 Protein
* Gene Deletion
* Gene Expression
* Histone Deacetylase Inhibitors
* Histone Deacetylases
* Hydroxamic Acids
* Mice, Transgenic
* Motor Activity
* Nerve Regeneration
* PTEN Phosphohydrolase
* Recovery of Function
* Spinal Cord
* Spinal Cord Injuries
|keywords=* Aging
* Epigenetics
* Histone deacetylase
* Pten
* Regeneration
* Spinal cord injury
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.006
}}
==GATA4==
 
{{medline-entry
|title=Epigenetics and Vascular Senescence-Potential New Therapeutic Targets?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33101015
 
 
|keywords=* calcification
* cell senescence
* epigenetics
* inflammation
* oxidation stress
* vascular aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556287
}}
{{medline-entry
|title=Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32843583
 
 
|keywords=* IGFBP-5
* Rho kinase inhibitor
* Y-27632
* dermal fibroblast
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485707
}}
==GBA==
 
{{medline-entry
|title=Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703585
 
|mesh-terms=* Aged
* Aging
* Female
* Glucosylceramidase
* Humans
* Hydrolases
* Lysosomes
* Male
* Mutation
* Parkinson Disease
* Risk Factors
* Substantia Nigra
* alpha-Synuclein
|keywords=* Ageing
* Ganglioside
* Glucocerebrosidase
* Glycosphingolipid
* Lysosome
* Neurodegeneration
* Parkinson’s disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842240
}}
==GC==
 
{{medline-entry
|title=Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274739
 
 
|keywords=*
          Chrysomya albiceps
       
* body size
* cuticular hydrocarbon
* forensic
* larval longevity
|full-text-url=https://sci-hub.do/10.1093/jme/tjaa256
}}
{{medline-entry
|title=Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33092723
 
 
|keywords=* Caenorhabditis elegans
* Fatty acid
* Flavonoid identification and composition
* Lifespan extension
* Tree peony petal
|full-text-url=https://sci-hub.do/10.1016/j.plaphy.2020.06.029
}}
{{medline-entry
|title=Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33039831
 
 
|keywords=* Aging
* Antioxidant
* Food packaging materials
* Microplastics
* Polypropylene
* seawater
|full-text-url=https://sci-hub.do/10.1016/j.watres.2020.116456
}}
{{medline-entry
|title=Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32989051
 
 
|keywords=* AMP-activated kinase (AMPK)
* Cell senescence
* cell cycle
* cellular senescence
* galectin
* galectin-3
* glycoprotein
* liver injury
* proliferation
* protein interaction
* protein-protein interaction
* quiescence
* stem cells
* stemness exhaustion
|full-text-url=https://sci-hub.do/10.1074/jbc.RA120.012974
}}
{{medline-entry
|title=Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679756
 
 
|keywords=* aging
* cellulose insulation
* gas chromatography
* headspace sampling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407484
}}
{{medline-entry
|title=Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569964
 
|mesh-terms=* Fruit
* Gas Chromatography-Mass Spectrometry
* Hexanols
* Norisoprenoids
* Odorants
* Olfactometry
* Principal Component Analysis
* Sulfhydryl Compounds
* Vitis
* Volatile Organic Compounds
|keywords=* Aging
* Aroma precursors
* Glycosides
* Lipid-derived aroma
* Norisoprenoids
* Sensory properties
* Terpenols
* Volatile phenols
|full-text-url=https://sci-hub.do/10.1016/j.foodchem.2020.127207
}}
{{medline-entry
|title=Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529058
 
 
|keywords=* Accelerated cognitive ageing
* Ageing
* Aging
* Biomarkers
* Clinical research
* Cognition
* Cognitive decline
* Cognitive neuroscience
* Effective connectivity
* Epilepsy
* Fmri
* Granger causality
* Image processing
* Medical imaging
* Mental health
* Nervous system
* Neuroscience
* Psychiatry
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283153
}}
{{medline-entry
|title=Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry ([[GC]]-IMS).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417671
 
 
|keywords=* Aging
* Electronic-nose
* Gas chromatography-ion mobility spectrometry
* Jinhua ham
* Volatiles
|full-text-url=https://sci-hub.do/10.1016/j.meatsci.2020.108178
}}
{{medline-entry
|title=Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32410029
 
 
|keywords=* Aging
* C. elegans
* Fat
* Fatty acids
* Gas chromatography–mass spectrometry
* Lipids
* Phospholipids
* Solid-phase chromatography
* Triglycerides
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0592-9_10
}}
{{medline-entry
|title=Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172871
 
|mesh-terms=* Aging
* Agrocybe
* Antioxidants
* Carbohydrate Sequence
* Cell Line
* Chemical Phenomena
* G1 Phase Cell Cycle Checkpoints
* Humans
* Membrane Potential, Mitochondrial
* Mitochondria
* Polysaccharides
|keywords=* Agrocybe aegirita polysaccharide
* Anti-ageing
* Cell cycle
* Mitochondrial membrane potential
* Structure
|full-text-url=https://sci-hub.do/10.1016/j.carbpol.2020.116056
}}
{{medline-entry
|title=Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32070549
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Biphenyl Compounds
* Carbohydrate Conformation
* Galactans
* Male
* Mentha
* Mice
* Mice, Inbred Strains
* Particle Size
* Picrates
* Surface Properties
|keywords=* Anti-aging activity
* Antioxidant activity
* Mentha haplocalyx Briq
* Polysaccharides
|full-text-url=https://sci-hub.do/10.1016/j.carbpol.2020.115936
}}
{{medline-entry
|title=Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32052967
 
 
|keywords=* Cognac
* aging aroma
* lees
* monoterpenes
* perceptual synergic effects
|full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b06656
}}
{{medline-entry
|title=Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31912134
 
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Female
* Fetus
* Formates
* Liver
* Maternal-Fetal Exchange
* Mothers
* Placenta
* Pregnancy
* Rats
* Rats, Sprague-Dawley
|keywords=* fetus
* glycine
* methionine
* mitochondria
* one-carbon metabolism
* pregnancy
* serine
* tetrahydrofolate
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198295
}}
{{medline-entry
|title=Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31882095
 
 
|keywords=* Aging
* Glycosidic precursors
* Grape aroma
* Grape quality
* Hydrolysis
* Polyphenols
* Wine
|full-text-url=https://sci-hub.do/10.1016/j.foodres.2019.108728
}}
{{medline-entry
|title=Compromised steady-state germinal center activity with age in nonhuman primates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840398
 
|mesh-terms=* Aging
* Animals
* Antigens, CD
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Forkhead Transcription Factors
* Germinal Center
* Granulocytes
* Immunity, Humoral
* Inflammation
* Lymph Nodes
* Macaca mulatta
* Monocytes
|keywords=* B cells
* Tfh cells
* aging
* follicles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996951
}}
{{medline-entry
|title=Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749087
 
|mesh-terms=* Adipose Tissue
* Adiposity
* Animals
* Bone Marrow
* Energy Metabolism
* Glucocorticoids
* Homeostasis
* Humans
* Liver
* Muscle, Skeletal
* Receptor Cross-Talk
* Receptors, Glucocorticoid
* Signal Transduction
* Stress, Physiological
|keywords=* Adipocyte
* Aging
* Bone marrow
* Corticosterone
* Cortisol
* Cortisone
* Glucocorticoid
* Osteoblast
|full-text-url=https://sci-hub.do/10.1007/s11914-019-00554-6
}}
{{medline-entry
|title=4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31639393
 
|mesh-terms=* Animals
* Antineoplastic Agents
* Apoptosis
* Cell Cycle
* Cell Proliferation
* Cellular Senescence
* DNA Damage
* Humans
* Mice
* Mice, Inbred BALB C
* Mice, Nude
* Picolinic Acids
* Signal Transduction
* Stomach Neoplasms
* Tumor Cells, Cultured
* Xenograft Model Antitumor Assays
|keywords=* Cellular senescence
* DNA damage
* Gastric cancer
* N-heterocyclic compound
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.116973
}}
{{medline-entry
|title=Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573616
 
|mesh-terms=* Administration, Oral
* Aging
* Animals
* Body Temperature
* Cerebellum
* Cyclopropanes
* Dose-Response Relationship, Drug
* Hydrocarbons, Fluorinated
* Liver
* Male
* Pyrethrins
* Rats
* Rats, Wistar
* Tissue Distribution
* Toxicokinetics
|keywords=* acute effects
* bifenthrin
* body temperature
* disposition
* rat
* tefluthrin
|full-text-url=https://sci-hub.do/10.1093/toxsci/kfz204
}}
{{medline-entry
|title=Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547291
 
|mesh-terms=* Aged
* Beta vulgaris
* Breath Tests
* Dietary Supplements
* Double-Blind Method
* Exhalation
* Fatty Acids, Volatile
* Feces
* Female
* Gastrointestinal Microbiome
* Healthy Volunteers
* Humans
* Male
* Pectins
* Volatile Organic Compounds
* Young Adult
|keywords=* aging
* dietary fiber
* elderly
* exhaled air
* microbiota
* pectin
* young adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770243
}}
{{medline-entry
|title=Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520920
 
|mesh-terms=* Alkanes
* Diacetyl
* Ethanol
* Fruit and Vegetable Juices
* Gas Chromatography-Mass Spectrometry
* Humans
* Hydrogen-Ion Concentration
* Ketones
* Limit of Detection
* Solid Phase Microextraction
* Stereoisomerism
* Time Factors
* Wine
|keywords=* 3-methyl-2,4-nonanedione
* Aroma precursor
* Hydroxy ketones
* Oxidation
* Premature aging
* Wine
|full-text-url=https://sci-hub.do/10.1016/j.foodchem.2019.125486
}}
{{medline-entry
|title=Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31456798
 
|mesh-terms=* Adaptive Immunity
* Adjuvants, Immunologic
* Aging
* Animals
* Animals, Newborn
* Germinal Center
* Immunity, Innate
* Interleukin-13
* Lymphopoiesis
* Mice, Inbred C57BL
* T-Lymphocytes, Helper-Inducer
* Th2 Cells
* Transcriptome
|keywords=* T follicular helper cells
* adjuvant
* neonates
* transcriptional profile analysis
* vaccines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700230
}}
{{medline-entry
|title=Identification of Dialkylpyrazines Off-Flavors in Oak Wood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31423769
 
|mesh-terms=* Flavoring Agents
* Gas Chromatography-Mass Spectrometry
* Odorants
* Olfactometry
* Pyrazines
* Quercus
* Wood
|keywords=* aroma
* barrel aging
* dialkylpyrazine
* oak wood
* off-flavor
* wine
|full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b03185
}}
{{medline-entry
|title=Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440390
 
 
|keywords=* aging
* biomarker
* metabolomics
* sepsis
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675524
}}
==GCA==
 
{{medline-entry
|title=Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32683496
 
 
|keywords=* Giant cell arteritis
* Longevity
* Mortality
* Polymyalgia rheumatica
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591435
}}
{{medline-entry
|title=Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32662384
 
 
|keywords=* Aging
* Alcohol drinking
* Apolipoprotein E4 (ApoE)
* Cognitive abilities
* Male
* Middle aged
* Risk factors
|full-text-url=https://sci-hub.do/10.1017/S1355617720000570
}}
==GCK==
 
{{medline-entry
|title=The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31558549
 
|mesh-terms=* Biomarkers
* Child
* Cost-Benefit Analysis
* Diabetes Mellitus, Type 2
* Female
* Genetic Testing
* Health Care Costs
* Humans
* Life Expectancy
* Male
* Mass Screening
* Pedigree
* Precision Medicine
* Quality-Adjusted Life Years
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868460
}}
==GCLC==
 
{{medline-entry
|title=Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866619
 
 
|keywords=* Aging
* Exercise
* GCLC
* NQO1
* Nrf2 signaling
* Redox homeostasis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704731
}}
==GCLM==
 
{{medline-entry
|title=Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31422075
 
|mesh-terms=* Adult
* Aged
* Aging
* Basic-Leucine Zipper Transcription Factors
* Bronchi
* Epithelial Cells
* Gene Expression
* Gene Silencing
* Glutamate-Cysteine Ligase
* Heme Oxygenase-1
* Humans
* Isothiocyanates
* Middle Aged
* NAD(P)H Dehydrogenase (Quinone)
* NF-E2-Related Factor 2
* RNA, Messenger
* RNA, Small Interfering
* Signal Transduction
* Young Adult
|keywords=* Aging
* Bach1
* Glutamate cysteine ligase
* Heme oxygenase
* Nrf2
* Sulforaphane
|full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108074
}}
==GDF11==
 
{{medline-entry
|title=Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32365331
 
 
|keywords=* GDF11
* White matter integrity
* aging
* gliosis
* stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244081
}}
{{medline-entry
|title=Anti-Aging Effects of [[GDF11]] on Skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32283613
 
 
|keywords=* disease
* growth factors
* regeneration
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177281
}}
{{medline-entry
|title=Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and [[GDF11]] in Mouse Serum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104967
 
 
|keywords=* GDF11
* aging
* immunoprecipitation
* myostatin/GDF8
* serum
* targeted-quantitative proteomics
|full-text-url=https://sci-hub.do/10.1002/pmic.201900104
}}
{{medline-entry
|title=Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31983062
 
 
|keywords=* aging
* alveolar bone loss
* dental implants
* osseointegration
* transforming growth factors
|full-text-url=https://sci-hub.do/10.1002/JPER.19-0247
}}
{{medline-entry
|title=Systemic [[GDF11]] stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31637864
 
 
|keywords=* GDF11
* adiponectin
* aging
* calorie restriction
* heterochronic parabiosis
* rejuvenation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974718
}}
{{medline-entry
|title=Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400495
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Blood
* Bone Morphogenetic Proteins
* Chemokine CCL11
* Enzyme Therapy
* Enzymes
* Growth Differentiation Factors
* Mice
* Neurodegenerative Diseases
* Parabiosis
* Vascular Diseases
|keywords=* C-C motif chemokine 11
* Circulating factor
* Growth differentiation factor 11
* Neurodegenerative diseases
* Neurovascular diseases
* Young blood
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2019.08.004
}}
{{medline-entry
|title=Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417428
 
 
|keywords=* aging
* exercise
* growth and differentiation factor 11
* sarcopenia
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684741
}}
==GDF15==
 
{{medline-entry
|title=Disease-specific plasma levels of mitokines FGF21, [[GDF15]], and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33131010
 
 
|keywords=* AD
* Aging
* FGF21
* GDF15
* Humanin
* T2D
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00287-w
}}
{{medline-entry
|title=Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32691494
 
 
|keywords=* T cell
* aging
* inflammation
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431835
}}
{{medline-entry
|title=Analysis of Epigenetic Age Predictors in Pain-Related Conditions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582603
 
 
|keywords=* DNA methylation
* aging biomarker
* chronic pain
* epigenetic aging
* epigenetic clock
* fibromyalgia
* headache
* pain sensitivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296181
}}
{{medline-entry
|title=[[GDF15]] Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477368
 
 
|keywords=* GDF15
* healthy aging
* inflammation
* physical activity
* sedentarity
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235447
}}
{{medline-entry
|title=[[GDF15]] is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432710
 
|mesh-terms=* Aged
* Alveolar Epithelial Cells
* Animals
* Bleomycin
* Bronchoalveolar Lavage Fluid
* Case-Control Studies
* Disease Models, Animal
* Female
* Gene Expression Profiling
* Growth Differentiation Factor 15
* Humans
* Idiopathic Pulmonary Fibrosis
* Lung
* Male
* Mice
* Middle Aged
* Respiratory Function Tests
* Severity of Illness Index
* Survival Analysis
* Telomere
* Transcriptome
|keywords=* MIC-1
* NAG-1
* SASP
* aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842909
}}
{{medline-entry
|title=Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor [[GDF15]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389184
 
|mesh-terms=* Aging
* Cells, Cultured
* Cellular Senescence
* Colonic Neoplasms
* Fibroblasts
* Growth Differentiation Factor 15
* HEK293 Cells
* Humans
* Phenotype
* RNA, Messenger
* Tumor Microenvironment
|keywords=* GDF15
* colon organoids
* colorectal cancer
* microenvironment
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826139
}}
==GDF5==
 
{{medline-entry
|title=An embryonic CaVβ1 isoform promotes muscle mass maintenance via [[GDF5]] signaling in adult mouse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31694926
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Atrophy
* Calcium Channels, L-Type
* Denervation
* Embryo, Mammalian
* Exons
* Female
* Gene Expression Regulation, Developmental
* Growth Differentiation Factor 5
* Humans
* Male
* Mice
* Muscles
* Neuromuscular Junction
* Organ Size
* Physical Conditioning, Animal
* Protein Isoforms
* RNA Splicing
* Signal Transduction
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.aaw1131
}}
==GDNF==
 
{{medline-entry
|title=GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal [[GDNF]] in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31538765
 
|mesh-terms=* Aging
* Animals
* Dopamine
* Glial Cell Line-Derived Neurotrophic Factor
* Glial Cell Line-Derived Neurotrophic Factor Receptors
* Neurons
* Oxidopamine
* Phosphorylation
* Rats
* Substantia Nigra
* Tyrosine 3-Monooxygenase
|keywords=* 6-hydroxydopamine
* Parkinson’s disease
* Substantia nigra
* aging
* nigrostriatal
* tyrosine hydroxylase
|full-text-url=https://sci-hub.do/10.1021/acschemneuro.9b00291
}}
==GEM==
 
{{medline-entry
|title=The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904804
 
 
|keywords=* emergency department
* geriatric emergency management nurses
* geriatrics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458600
}}
==GFAP==
 
{{medline-entry
|title=Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32990851
 
 
|keywords=* aging
* dorsal root ganglion
* satellite cells
* systemic inflammation
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04950-2
}}
{{medline-entry
|title=Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32868457
 
 
|keywords=* Parkinson's disease
* aging
* locus ceruleus
* nonmotor
* norepinephrine
* α-synuclein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511194
}}
{{medline-entry
|title=ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630431
 
 
|keywords=* Alzheimer’s disease
* ApoE
* aging
* antioxidants
* cognition
* exercise
* motor
* oxidative stress
* vitamin C
* vitamin E
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346214
}}
{{medline-entry
|title=Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581775
 
 
|keywords=* Sholl analysis
* aging
* astrocyte
* cell morphology
* heterogeneity
* olfactory bulb
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296154
}}
{{medline-entry
|title=Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455600
 
 
|keywords=* CD45
* EA microdispersion (EAm)
* GFAP
* aging
* behavioral skills
* ellagic acid (EA)
* mice
* noradrenaline
* oral administration
* principal component analysis (PCA)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279224
}}
{{medline-entry
|title=Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285289
 
 
|keywords=* Autophagy
* Behavior
* Longevity
* Middle-aged rats
* Neuroinflammation
* Spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287009
}}
{{medline-entry
|title=Meta-analysis of human prefrontal cortex reveals activation of [[GFAP]] and decline of synaptic transmission in the aging brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32138778
 
 
|keywords=* Aging
* Meta-analysis
* Prefrontal cortex
* Sex-specific
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059712
}}
{{medline-entry
|title=Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030764
 
 
|keywords=* BCAA
* ER stress
* aging
* autophagy
* lipogenesis
* mTORC1
|full-text-url=https://sci-hub.do/10.1111/jnc.14979
}}
{{medline-entry
|title=Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32013718
 
 
|keywords=* Aging
* chaperone-mediated autophagy
* endocrine control of autophagy
* endocrine signaling
* growth hormone
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1725378
}}
{{medline-entry
|title=Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31997558
 
 
|keywords=* Alzheimer's disease
* aging
* lipopolysaccharide
* memory
* mice
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066339
}}
{{medline-entry
|title=Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907998
 
|mesh-terms=* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Astrocytes
* Gene Knock-In Techniques
* Longevity
* Mice
* Mice, Knockout
* Mice, Obese
* Microglia
* Peptide Fragments
|keywords=* Alzheimer's disease
* astrocytes
* diabetes
* lifespan
* microglia
* obesity
|full-text-url=https://sci-hub.do/10.1096/fj.201901028RR
}}
{{medline-entry
|title=Selective brain neuronal and glial losses without changes in [[GFAP]] immunoreactivity: Young versus mature adult Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31404554
 
|mesh-terms=* Aging
* Animals
* Brain
* Glial Fibrillary Acidic Protein
* Male
* Neuroglia
* Neurons
* Rats
* Rats, Wistar
|keywords=* Ageing
* Astrocytes
* GFAP
* Glia
* Neurons
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111128
}}
==GGCT==
 
{{medline-entry
|title=Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31519583
 
|mesh-terms=* Antineoplastic Agents
* Apoptosis
* Cell Line, Tumor
* Cell Proliferation
* Cellular Senescence
* Docetaxel
* Enzyme Inhibitors
* Gene Expression
* Humans
* Immunohistochemistry
* Male
* Prostatic Neoplasms
* RNA, Small Interfering
* gamma-Glutamylcyclotransferase
|keywords=* docetaxel
* pro-GA
* prostate cancer cells
* senescence
* γ-glutamylcyclotransferase
|full-text-url=https://sci-hub.do/10.21873/anticanres.13666
}}
==GHR==
 
{{medline-entry
|title=Tissue-Specific [[GHR]] Knockout Mice: An Updated Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33162937
 
 
|keywords=* aging
* growth hormone
* longevity
* metabolism
* mice
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581730
}}
==GHRH==
 
{{medline-entry
|title=Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32422607
 
 
|keywords=* CRISPR
* GHRH
* aging
* lifespan
* metabolism
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288930
}}
{{medline-entry
|title=Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32091406
 
 
|keywords=* aging
* growth hormone
* metabolite
* mouse
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066919
}}
==GIP==
 
{{medline-entry
|title=Absence of [[GIP]] secretion alleviates age-related obesity and insulin resistance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31977316
 
|mesh-terms=* Adiponectin
* Adipose Tissue
* Age Factors
* Animals
* Diet
* Diet, High-Fat
* Enteroendocrine Cells
* Gastric Inhibitory Polypeptide
* Gene Expression
* Glucose Tolerance Test
* Insulin
* Insulin Resistance
* Leptin
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
* Obesity
|keywords=* GIP
* aging
* incretin
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040458
}}
==GIT2==
 
{{medline-entry
|title=Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic [[GIT2]] in aging trajectories.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574270
 
|mesh-terms=* Aging
* Animals
* Cluster Analysis
* Computational Biology
* Female
* GTPase-Activating Proteins
* Hypothalamus
* Longevity
* Male
* Mice
* Mice, Inbred C57BL
* RNA
* Sex Characteristics
* Signal Transduction
* Transcriptome
|keywords=* Aging
* Female
* GIT2
* Hypothalamus
* Longevity
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111150
}}
==GJC2==
 
{{medline-entry
|title=Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32629311
 
 
|keywords=* Brain aging
* Cell adhesion molecules
* RNA sequencing
* Zebrafish
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.04.017
}}
==GK==
 
{{medline-entry
|title=Progression of diabetic kidney disease in T2DN rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566426
 
|mesh-terms=* Aging
* Albuminuria
* Animals
* Blood Glucose
* Diabetes Mellitus, Type 2
* Diabetic Nephropathies
* Disease Progression
* Hypertrophy
* Kidney Glomerulus
* Male
* Membrane Proteins
* Organ Size
* Polyuria
* Rats
* Rats, Wistar
* Renin-Angiotensin System
* Water-Electrolyte Imbalance
|keywords=* diabetic glomerular disease
* diabetic nephropathy
* podocyte pathology
* renin-angiotensin-aldosterone system
* scanning ion microscopy
* type 2 diabetic nephropathy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960784
}}
==GNAQ==
 
{{medline-entry
|title=[[GNAQ]]  expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31680437
 
|mesh-terms=* Aging
* Animals
* Central Nervous System Neoplasms
* Disease Models, Animal
* Disease Progression
* Embryonic Development
* Female
* GTP-Binding Protein alpha Subunits, Gq-G11
* Male
* Melanocytes
* Melanoma
* Meningeal Neoplasms
* Mice, Transgenic
* Multipotent Stem Cells
* Mutation
* Neoplasm Invasiveness
* Neural Crest
* Nevus
* Skin Neoplasms
* Uveal Neoplasms
|keywords=* GNAQ
* Plp1
* blue nevus
* leptomeningeal melanocytoma
* uveal melanoma
|full-text-url=https://sci-hub.do/10.1111/pcmr.12843
}}
==GNE==
 
{{medline-entry
|title=Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2  mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33300446
 
 
|keywords=* Aging
* Dnm1l/DRP1
* SQSTM1/p62
* knockin mice
* macroautophagy
* mitochondria dysfunction
* mitochondrial fission
* mitophagy
* parkinson disease
* ubiquitination
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1850008
}}
==GPC1==
 
{{medline-entry
|title=Decreased expression of [[GPC1]] in human skin keratinocytes and epidermis during ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31430521
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cell Proliferation
* Cells, Cultured
* Epidermis
* Female
* Fibroblast Growth Factor 2
* Gene Expression Regulation
* Glypicans
* Humans
* Keratinocytes
* Middle Aged
* RNA, Messenger
* Signal Transduction
* Skin
* Young Adult
|keywords=* Ageing
* Epidermis
* Glypican 1
* Human skin
* Keratinocytes
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110693
}}
==GPI==
 
{{medline-entry
|title=Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32646997
 
|mesh-terms=* Aging
* Animals
* Blood Circulation
* Brain
* Cognition
* Cognitive Dysfunction
* Glycosylphosphatidylinositols
* Liver
* Mice
* Neurogenesis
* Phospholipase D
* Physical Conditioning, Animal
* Regeneration
* Signal Transduction
 
|full-text-url=https://sci-hub.do/10.1126/science.aaw2622
}}
==GPR6==
 
{{medline-entry
|title=Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32959881
 
 
|keywords=* HIV
* aging
* epigenetics
* methylation
|full-text-url=https://sci-hub.do/10.1093/infdis/jiaa599
}}
==GPT==
 
{{medline-entry
|title=Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32631206
 
 
|keywords=* aging
* gray matter
* visuomotor function
* white matter
|full-text-url=https://sci-hub.do/10.1080/00222895.2020.1787320
}}
==GPX1==
 
{{medline-entry
|title=Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32400101
 
 
|keywords=* glutathione peroxidase-1
* kidney aging
* mitochondria
* proteomics
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294784
}}
==GPX3==
 
{{medline-entry
|title=Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814699
 
|mesh-terms=* Aging
* Anterior Capsule of the Lens
* Apoptosis
* Cataract
* Cell Line
* Cell Nucleus
* Epithelial Cells
* Glutathione Peroxidase
* Humans
* Hydrogen Peroxide
* Lens, Crystalline
* RNA, Long Noncoding
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857780
}}
==GPX4==
 
{{medline-entry
|title=l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837632
 
|mesh-terms=* Animals
* Carnitine
* Cattle
* Culture Media
* Embryo Culture Techniques
* Female
* Fertilization in Vitro
* In Vitro Oocyte Maturation Techniques
* Oocytes
* Oxidative Stress
|keywords=* Bovine
* Embryo development
* Oocyte aging
* l-carnitine
|full-text-url=https://sci-hub.do/10.1016/j.theriogenology.2019.11.036
}}
{{medline-entry
|title=Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31835711
 
 
|keywords=* GPX4
* Gpx1
* Gpx3
* Selenof
* apoptosis
* embryo
* follicle development
* ovarian aging
* selenium
* selenoprotein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969897
}}
==GREM1==
 
{{medline-entry
|title=[[GREM1]] inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151168
 
 
|keywords=* BMP
* GREM1
* adipose-derived stem cells (ADSCs)
* osteogenic differentiation
* senescence
|full-text-url=https://sci-hub.do/10.1080/03008207.2020.1736054
}}
==GREM2==
 
{{medline-entry
|title=Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31709279
 
 
|keywords=* Adipogenic differentiation
* Adipose-derived stromal/stem stem cells
* Aging
* DAPI, 4′,6-diamidino-2-phenylindole
* FGF, fibroblast growth factor
* GREM2
* GREM2 knockdown
* HE, hematoxylin eosin
* Individual differences
* PBS, phosphate buffered Solution
* PFA, paraformaldehyde
* TGF-β, transforming growth factor beta
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831850
}}
==GRID1==
 
{{medline-entry
|title=Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109663
 
 
|keywords=* GWAS
* HDL-C metabolism
* Healthy aging
* Longevity
* Longitudinal HDL-C change
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2020.02.005
}}
==GRIK2==
 
{{medline-entry
|title=Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099472
 
 
|keywords=* GluR6
* Grik2
* Senescence
* cancer
* glutamate receptor
* normal fibroblasts
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675648
}}
==GRK2==
 
{{medline-entry
|title=G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33064264
 
 
|keywords=* Aging
* Caenorhabditis elegans (C. elegans)
* G protein coupled receptor kinase (GRK)
* Oxidative stress
* Resistance
* Stress response
|full-text-url=https://sci-hub.do/10.1007/s12192-020-01168-z
}}
{{medline-entry
|title=G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768194
 
 
|keywords=* Aging
* Biological control
* Caenorhabditis elegans (C. elegans)
* G protein coupled receptor (GPCR)
* G protein coupled receptor kinase (GRK)
* Heat stress
* Resistance
* Stress response
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.07.121
}}
{{medline-entry
|title=Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32216616
 
|mesh-terms=* Aging
* Animals
* Female
* G Protein-Coupled Inwardly-Rectifying Potassium Channels
* Heart
* Heart Diseases
* Homeostasis
* Male
* Mice
* Mutation
* Myocardium
* Nitric Oxide
|keywords=* S-nitrosylation
* cardiac hypertrophy
* heart disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346533
}}
==GRM3==
 
{{medline-entry
|title=Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203495
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Bipolar Disorder
* Dentate Gyrus
* Depressive Disorder, Major
* Female
* Gene Expression Profiling
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Humans
* Male
* Middle Aged
* Neurons
* Quantitative Trait Loci
* Schizophrenia
* Transcriptome
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1038/s41593-020-0604-z
}}
==GRN==
 
{{medline-entry
|title=Stressful development: Integrating endoderm development, stress, and longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307045
 
 
|keywords=* Caenorhabditis elegans
* Embryonic development
* Epigenetics inheritance
* Innate immunity
* Longevity
* Pleiotropy
* Stress
|full-text-url=https://sci-hub.do/10.1016/j.ydbio.2020.12.002
}}
{{medline-entry
|title=A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681955
 
 
|keywords=* Aging
* Geriatric nursing
* Health care professionals
* Intervention
* Quality improvement
|full-text-url=https://sci-hub.do/10.1093/geront/gnz150
}}
==GSC==
 
{{medline-entry
|title=[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744422
 
|mesh-terms=* Aging
* Animals
* Cellular Senescence
* Drosophila Proteins
* Drosophila melanogaster
* Female
* Germ Cells
* Nuclear Proteins
* Ovary
* Receptors, Notch
* Signal Transduction
* Stem Cell Niche
* Transcriptome
|keywords=* DE-cadherin
* Drosophila oogenesis
* Hedgehog
* mastermind
* niche ageing
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893403
}}
==GSTM1==
 
{{medline-entry
|title=The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33272294
 
 
|keywords=* Biological aging
* DNA adduct
* Mitochondrial DNA copy number
* Polycyclic aromatic hydrocarbon
* Structural equation modelling
* Telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713168
}}
==GSTM2==
 
{{medline-entry
|title=Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32574561
 
 
|keywords=* 4-HNE
* EV
* GSH
* GST
* ROS
* SASP
* aging
* extracellular vesicles
* glutathione metabolism
* glutathione-S-transferase
* lipid peroxidation
* rejuvenation
* senescence
* senescence-associated secretory phenotype
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342013
}}
==GUK1==
 
{{medline-entry
|title=Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32232569
 
 
|keywords=* Aging
* GDP
* GMP
* Mycophenolic acid
* Proteasome
* Replicative lifespan
* Yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367712
}}
==GZMK==
 
{{medline-entry
|title=Comprehensive Profiling of an Aging Immune System Reveals Clonal [[GZMK]]  CD8  T Cells as Conserved Hallmark of Inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271118
 
 
|keywords=* Aging
* CD8 T cells
* CITE-seq
* granzyme K
* immune system
* inflammaging
* single-cell ATAC-sequencing
* single-cell BCR-sequencing
* single-cell RNA-sequencing
* single-cell TCR-sequencing
|full-text-url=https://sci-hub.do/10.1016/j.immuni.2020.11.005
}}
==H2AX==
 
{{medline-entry
|title=Evaluation of Gamma[[H2AX]] in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781776
 
 
|keywords=* Alzheimer’s disease
* DNA damage
* mild cognitive impairment
* senescence
* γH2AX
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459751
}}
{{medline-entry
|title=Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32597980
 
 
|keywords=* cisplatin
* neuropathy
* neurotoxicity
* p21
* senescence
|full-text-url=https://sci-hub.do/10.1093/neuonc/noaa151
}}
{{medline-entry
|title=Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32215662
 
 
|keywords=*  DNA damage
*  UV-induced keratinocyte senescence
*  guanine deaminase
*  reactive oxygen species
*  uric acid
* seborrhoeic keratosis
|full-text-url=https://sci-hub.do/10.2340/00015555-3473
}}
{{medline-entry
|title=Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772111
 
|mesh-terms=* Adolescent
* Adult
* Aging
* BRCA1 Protein
* BRCA2 Protein
* Female
* Germ-Line Mutation
* Heterozygote
* Humans
* Immunohistochemistry
* Middle Aged
* Observational Studies as Topic
* Ovarian Follicle
* Ovarian Reserve
* Prospective Studies
* Research Design
* Young Adult
|keywords=* BRCA
* DNA repair
* fertility
* follicle
* germline mutation
* oocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887091
}}
{{medline-entry
|title=Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730540
 
|mesh-terms=* Animals
* Birds
* Bottle-Nosed Dolphin
* Cross-Sectional Studies
* DNA Damage
* Goats
* Leukocytes
* Longevity
* Reindeer
* Turtles
* Vertebrates
|keywords=* DNA damage
* lifespan
* short telomeres
* species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874430
}}
{{medline-entry
|title=Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone [[H2AX]] phosphorylation in plant growth under genotoxic stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31410901
 
|mesh-terms=* ATP-Binding Cassette Transporters
* Aging
* Arabidopsis
* Arabidopsis Proteins
* Cells, Cultured
* DNA Damage
* DNA Repair
* Gene Expression Regulation, Plant
* Gene Ontology
* Germination
* Histones
* Mass Spectrometry
* Phosphorylation
* Proteome
* Seeds
* Serine
* Signal Transduction
* Stress, Physiological
* X-Rays
|keywords=* ATAXIA TELANGIECTASIA MUTATED (ATM)
* DNA damage response
* DNA repair
* phosphorylation
* seed
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900162
}}
==HBM==
 
{{medline-entry
|title=The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553309
 
|mesh-terms=* Adipose Tissue
* Adiposity
* Animals
* Bone Density
* Bone Marrow
* Dietary Fats
* Dietary Supplements
* Disease Models, Animal
* Fatty Acids, Omega-3
* Female
* Femur
* Mice
* Osteoporosis
* X-Ray Microtomography
|keywords=* SAMP8 mouse
* aging
* fish oil
* marrow adipose tissue
* osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781972
}}
==HBP1==
 
{{medline-entry
|title=Suppression of p38/[[HBP1]] pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32549582
 
|mesh-terms=* Cellular Senescence
* Chondrocytes
* Disease Progression
* High Mobility Group Proteins
* Humans
* Osteoarthritis
* Repressor Proteins
* Up-Regulation
* p38 Mitogen-Activated Protein Kinases
|keywords=* HBP1
* chondrocyte
* osmolality stress
* p38
* senescence
|full-text-url=https://sci-hub.do/10.23812/20-63-A-6
}}
==HCN1==
 
{{medline-entry
|title=Protein expression changes of [[HCN1]] and HCN2 in hippocampal subregions of gerbils during the normal aging process.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32128096
 
 
|keywords=* Aging
* Dentate gyrus
* Granule cells
* HCN channel
* Hippocampus proper
* Pyramidal cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038419
}}
==HDAC1==
 
{{medline-entry
|title=[[HDAC1]] modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424276
 
|mesh-terms=* Acetylation
* Aging
* Alzheimer Disease
* Animals
* Astrocytes
* Base Sequence
* Benzophenones
* Brain
* Cognition
* Cognition Disorders
* DNA Damage
* DNA Glycosylases
* Down-Regulation
* Gene Ontology
* Guanine
* Histone Deacetylase 1
* Memory
* Mice, Inbred C57BL
* Mice, Knockout
* Neurons
* Oxidative Stress
* Promoter Regions, Genetic
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235043
}}
==HDAC10==
 
{{medline-entry
|title=Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31434815
 
|mesh-terms=* Acetylation
* Age Factors
* Animals
* Estradiol
* Female
* Histones
* Hypothalamus, Anterior
* Luteinizing Hormone
* Rats
* Rats, Sprague-Dawley
|keywords=* Histone acetylation
* LH
* aging
* histone deacetylases
* hypothalamus
|full-text-url=https://sci-hub.do/10.5582/bst.2019.01162
}}
==HDAC2==
 
{{medline-entry
|title=EEF1A1 deacetylation enables transcriptional activation of remyelination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647127
 
|mesh-terms=* Acetylation
* Aging
* Animals
* Cell Dedifferentiation
* Cell Nucleus
* Histone Deacetylase 1
* Histone Deacetylase 2
* Lysine Acetyltransferase 5
* Mice
* Models, Biological
* Oligodendroglia
* Peptide Elongation Factor 1
* Peripheral Nervous System
* Recovery of Function
* Remyelination
* SOXE Transcription Factors
* STAT3 Transcription Factor
* Schwann Cells
* Theophylline
* Trans-Activators
* Transcriptional Activation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347577
}}
==HDAC3==
 
{{medline-entry
|title=Histone deacetylase-3: Friend and foe of the brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32486848
 
 
|keywords=* Histone deacetylases
* aging
* histone deacetylase-3
* learning and memory
* neurodegenerative diseases
* neurodevelopment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400723
}}
{{medline-entry
|title=Loss of [[HDAC3]] contributes to meiotic defects in aged oocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31498540
 
|mesh-terms=* Animals
* Cells, Cultured
* Cellular Senescence
* Female
* Histone Deacetylases
* Meiosis
* Mice
* Mice, Inbred ICR
* Oocytes
|keywords=* HDACs
* aneuploidy
* maternal aging
* oocyte quality
* reproduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826132
}}
==HDAC4==
 
{{medline-entry
|title=The posttranslational modification of [[HDAC4]] in cell biology: Mechanisms and potential targets.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588631
 
 
|keywords=* HDAC4
* cell senescence
* cellular apoptosis and autophagy
* glucose metabolism
* inflammation and pathology
* proliferation and differentiation
|full-text-url=https://sci-hub.do/10.1002/jcb.29365
}}
==HDAC6==
 
{{medline-entry
|title=Inhibition of [[HDAC6]] Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660051
 
 
|keywords=* HDAC6
* diabetic retinopathy
* oxidative stress
* retinal endothelial cell senescence
* retinal endothelial cells
* tubastatin A
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402090
}}
==HDC==
 
{{medline-entry
|title=Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115145
 
|mesh-terms=* Adult
* Aged, 80 and over
* Cell Differentiation
* Cell Line
* Cellular Reprogramming
* Cellular Senescence
* Child
* Clone Cells
* Gene Expression Regulation
* Humans
* Induced Pluripotent Stem Cells
* Mesenchymal Stem Cells
* Telomere Homeostasis
* Tissue Donors
* Transcriptome
|keywords=* Aging
* Longevity
* Reprogramming
* Supercentenarian
* Telomere
* iPSC
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.02.092
}}
==HES1==
 
{{medline-entry
|title=A Single-Cell Transcriptomic Atlas of Human Skin Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238152
 
 
|keywords=* HES1
* KLF6
* aging
* fibroblast
* keratinocyte
* quercetin
* senescence
* single-cell RNA sequencing
* skin
|full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.11.002
}}
==HFE==
 
{{medline-entry
|title=Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31739534
 
 
|keywords=* Himantoglossum robertianum
* antioxidants
* collagenase
* elastase
* flavonoids
* keratinocytes
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918203
}}
==HGD==
 
{{medline-entry
|title=High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31846489
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Diet
* Gene Expression Regulation
* Glucose
* Longevity
* Mitochondria
* Mitophagy
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917275
}}
==HGF==
 
{{medline-entry
|title=Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4  T cell subsets.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33223447
 
 
|keywords=* Aging
* CD4 T cell
* Dental pulp
* Immunomodulation
* Mesenchymal stem cell
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155367
}}
{{medline-entry
|title=Hepatocyte growth factor ([[HGF]]) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736659
 
 
|keywords=* Hepatocyte growth factor
* Mitochondrial function
* Osteogenic differentiation
* Senescence
* Stem cell factor
* Stem cells from human exfoliated deciduous teeth
* Stemness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393921
}}
{{medline-entry
|title=Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281104
 
 
|keywords=* aging
* autophagy
* gingival fibroblast
* phenytoin sodium
|full-text-url=https://sci-hub.do/10.1111/jre.12750
}}
{{medline-entry
|title=Impaired integrin α  /β  -mediated hepatocyte growth factor release by stellate cells of the aged liver.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32157808
 
 
|keywords=* aging
* hepatic stellate cells
* integrins
* laminins
* mechanobiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189994
}}
==HGS==
 
{{medline-entry
|title=Handgrip strength asymmetry is associated with future falls in older Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247424
 
 
|keywords=* Aging
* Functional laterality
* Geriatric assessment
* Geriatrics
* Muscle strength dynamometer
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01757-z
}}
{{medline-entry
|title=Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33142897
 
 
|keywords=* aging
* geriatric assessment
* muscle strength
* muscle weakness
* physical functional performance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709634
}}
{{medline-entry
|title=The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962093
 
 
|keywords=* aging
* depression
* disease comorbidities
* muscular strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558624
}}
{{medline-entry
|title=Handgrip Strength in the Korean Population: Normative Data and Cutoff Values.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32743310
 
 
|keywords=* Aging
* Hand strength
* Muscle strength
* Nutrition surveys
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370763
}}
{{medline-entry
|title=Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473060
 
 
|keywords=* aging
* functional laterality
* geriatric assessment
* geriatrics
* muscle strength dynamometer
|full-text-url=https://sci-hub.do/10.1111/jgs.16556
}}
{{medline-entry
|title=Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32384713
 
|mesh-terms=* Aged
* Aged, 80 and over
* Female
* Geriatric Assessment
* Hand Strength
* Humans
* Male
* Middle Aged
* Muscle Strength
* Muscle Strength Dynamometer
* Muscle Weakness
* Odds Ratio
* United States
|keywords=* aging
* geriatrics
* muscle strength
* muscle strength dynamometer
* nutrition surveys
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246814
}}
{{medline-entry
|title=Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31930203
 
 
|keywords=* aging
* epidemiology
* hand strength
* human development
* muscle weakness
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954001
}}
{{medline-entry
|title=Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931730
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Cross-Sectional Studies
* Entropy
* Female
* Hand Strength
* Heart Rate
* Humans
* Male
|keywords=* Aging
* Entropy
* Hand grip strength
* Nonlinear dynamics
* Poincaré plot
* Time series
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958685
}}
{{medline-entry
|title=Physical Activity and Fitness in White- and Blue-Collar Retired Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849269
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Body Mass Index
* Exercise
* Geriatric Assessment
* Humans
* Longitudinal Studies
* Male
* Men's Health
* Occupations
* Physical Fitness
* Poland
* Retirement
* Social Class
* Surveys and Questionnaires
* Task Performance and Analysis
|keywords=* Retirement
* occupation
* old men
* physical activity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920597
}}
{{medline-entry
|title=Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31842533
 
 
|keywords=* Hand Grip Strength
* Korean Longitudinal Study of Aging
* Self-Rated Health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987025
}}
{{medline-entry
|title=Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786197
 
 
|keywords=* Aging
* Epidemiology
* Geriatrics
* hand strength
* muscle strength
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186143
}}
{{medline-entry
|title=Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31743070
 
 
|keywords=* Dietary patterns
* Korea National Health and Nutrition Examination Survey
* aging
* diet
* handgrip strength
|full-text-url=https://sci-hub.do/10.1080/07315724.2019.1691955
}}
{{medline-entry
|title=Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574451
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cardiovascular Diseases
* Female
* Hand Strength
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Muscle Strength
* Muscle, Skeletal
* Republic of Korea
* Risk Factors
|keywords=* Cardiovascular disease
* KLoSA
* Relative handgrip strength
|full-text-url=https://sci-hub.do/10.1016/j.archger.2019.103937
}}
{{medline-entry
|title=Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520335
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aging
* Cognitive Dysfunction
* Geriatric Assessment
* Hand Strength
* Humans
* Middle Aged
|keywords=* Dementia
* Epidemiology
* Geriatrics
* Muscle strength
* Nervous system
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01351-y
}}
{{medline-entry
|title=Association of phase angle with sarcopenia and its components in physically active older women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31463928
 
|mesh-terms=* Aged
* Cross-Sectional Studies
* Electric Impedance
* Female
* Hand Strength
* Humans
* Muscle Strength
* Sarcopenia
* Walking Speed
|keywords=* Aging
* Bioimpedance
* Muscle function
* Muscle mass
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01325-0
}}
==HLA-DRB1==
 
{{medline-entry
|title=The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32942037
 
 
|keywords=* Aging
* B cell
* HLA-DR
* Interleukin-6
* Polymyalgia rheumatica
* T cell
|full-text-url=https://sci-hub.do/10.1016/j.autrev.2020.102670
}}
==HMGA1==
 
{{medline-entry
|title=Characterization of [i][[HMGA1]]P6[/i] transgenic mouse embryonic fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787507
 
 
|keywords=* CeRNA
* HMGA1
* HMGA1P6
* pseudogenes
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513866
}}
==HMGA2==
 
{{medline-entry
|title=4D Genome Rewiring during Oncogene-Induced and Replicative Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32220303
 
|mesh-terms=* Cells, Cultured
* Cellular Senescence
* Chromatin Assembly and Disassembly
* DNA (Cytosine-5-)-Methyltransferase 1
* DNA Methylation
* Fibroblasts
* Genome, Human
* Heterochromatin
* Humans
* In Situ Hybridization, Fluorescence
* Oncogenes
|keywords=* 3D genome architecture
* DNMT1
* Hi-C
* chromatin compartments
* gene regulation
* oncogene-induced senescence
* replicative senescence
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208559
}}
{{medline-entry
|title=The protective effects of [[HMGA2]] in the senescence process of bone marrow-derived mesenchymal stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068957
 
 
|keywords=* bone marrow derived mesenchymal stromal cells (MSCs)
* high-mobility group AT-hook 2 (HMGA2)
* regulator of G protein signaling 2 (Rgs2)
* senescence
|full-text-url=https://sci-hub.do/10.1002/term.3023
}}
==HMGB1==
 
{{medline-entry
|title=Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31633821
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Atrophy
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Epidermis
* Female
* Humans
* Male
* Melanocytes
* Middle Aged
* Paracrine Communication
* Reactive Oxygen Species
* Receptors, CXCR4
* Skin
* Telomere
* Young Adult
|keywords=*
SASP
 
* melanocytes
* senescence
* skin ageing
* telomeres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885734
}}
==HMGCR==
 
{{medline-entry
|title=Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33007859
 
 
|keywords=* aging
* cholesterol biosynthesis
* mathematical model
* reactive oxygen species
* systems biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599957
}}
{{medline-entry
|title=Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746143
 
 
|keywords=* artesunate
* distant seeding
* glioma
* mevalonate pathway
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933330
}}
==HOXD8==
 
{{medline-entry
|title=Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849838
 
 
|keywords=* Hoxd8
* cellular senescence
* mouse embryonic fibroblasts
* senescence-associated secretory phenotype
* single-cell RNA sequencing
* transcriptomic heterogeneity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431633
}}
==HP==
 
{{medline-entry
|title=A narrative review of highly processed food addiction across the lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33127423
 
 
|keywords=* Adolescence
* Adulthood
* Childhood
* Food addiction
* Infancy
* Lifespan
* Prenatal
|full-text-url=https://sci-hub.do/10.1016/j.pnpbp.2020.110152
}}
{{medline-entry
|title=Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238586
 
|mesh-terms=* Apoptosis
* Cell Cycle Proteins
* Cell Line, Tumor
* Cell Proliferation
* Cell Survival
* Cytochalasin B
* Cytokinesis
* DNA Repair
* E1A-Associated p300 Protein
* Gene Expression Regulation
* HCT116 Cells
* Host-Pathogen Interactions
* Humans
* Keratinocytes
* Oncogene Proteins, Viral
* Osteoblasts
* Papillomaviridae
* Phenotype
* Phosphorylation
* Primary Cell Culture
* Protein-Serine-Threonine Kinases
* Signal Transduction
* Transcription Factors
* Tumor Suppressor Protein p53
|keywords=* Hippo signaling pathway
* apoptosis
* cancer
* cytokinesis
* human papillomavirus
* senescence
* skin cancer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307087
}}
==HPSE==
 
{{medline-entry
|title=Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32159248
 
 
|keywords=* aging
* estrogen
* extracellular matrix
* heparan sulfate
* heparanase-1
* matrix metalloproteinase-9
|full-text-url=https://sci-hub.do/10.1002/cbin.11339
}}
==HR==
 
{{medline-entry
|title=Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33267795
 
 
|keywords=* Aging
* Cardiovascular reactivity
* Heart rate variability
* Hip fracture
* Total hip arthroplasty
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713041
}}
{{medline-entry
|title=Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271558
 
 
|keywords=* Aging
* Coronavirus disease
* Elderly
* Lung ultrasound
* Severe acute respiratory syndrome-coronavirus-2
|full-text-url=https://sci-hub.do/10.1159/000512209
}}
{{medline-entry
|title=The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33225345
 
 
|keywords=* Accelerometer
* Longevity
* Physical activity
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa227
}}
{{medline-entry
|title=Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33181317
 
 
|keywords=* Aging
* Exercise
* Mouse model
* Muscle morphology
* Skeletal muscle
* Training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111150
}}
{{medline-entry
|title=Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33121164
 
 
|keywords=* aging
* body composition
* gender
* heart disease
* lean mass
* obesity
* primary prevention
* women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693172
}}
{{medline-entry
|title=Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33095419
 
 
|keywords=* Aging
* Body mass index
* Bone mineral density
* Follow-up study
* General population
* Hip fracture
* Menopause
* Obesity
|full-text-url=https://sci-hub.do/10.1007/s00198-020-05665-w
}}
{{medline-entry
|title=ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33024871
 
 
|keywords=* Biochemistry
* Bioinformatics
* Cancer research
* Cell biology
* Cellular metabolism
* Cellular senescence
* Drug combinations
* Homologous recombination
* Metabolite
* Molecular biology
* PPARa
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527645
}}
{{medline-entry
|title=Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33015888
 
 
|keywords=* aging
* cancer
* chemotherapy
* comparative effectiveness research
* pharmacoepidemiology
|full-text-url=https://sci-hub.do/10.1002/pds.5148
}}
{{medline-entry
|title=Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32978065
 
|mesh-terms=* Age Factors
* Aged
* Aged, 80 and over
* Betacoronavirus
* COVID-19
* Comorbidity
* Coronavirus Infections
* Female
* Frail Elderly
* Geriatrics
* Humans
* Male
* Models, Statistical
* Outcome Assessment, Health Care
* Pandemics
* Pneumonia, Viral
* Prognosis
* SARS-CoV-2
* Survival Analysis
* Sweden
|keywords=* COVID-19
* aging
* comorbidity
* frailty
* geriatrics
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427570
}}
{{medline-entry
|title=Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32918697
 
 
|keywords=* Aging
* Cox regression
* Dementia
* Follow-up
* Mild cognitive impairment
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01697-8
}}
{{medline-entry
|title=Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785663
 
 
|keywords=* DHEA-S
* aging
* heart failure
* mortality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526732
}}
{{medline-entry
|title=High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721549
 
 
|keywords=* Aging
* Body composition
* Exercise
* Mobility
* Nutrition
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111036
}}
{{medline-entry
|title=Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738383
 
 
|keywords=* Aging
* Blood pressure
* Falls
* Injury
* Swedish National study on Aging and Care in Kungsholmen (SNAC-K)
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111038
}}
{{medline-entry
|title=Epigenetic age acceleration and clinical outcomes in gliomas.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32692766
 
|mesh-terms=* Adult
* Aging
* DNA Methylation
* Epigenesis, Genetic
* Female
* Glioma
* Humans
* Male
* Middle Aged
* Prognosis
* Survival Analysis
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373289
}}
{{medline-entry
|title=Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666833
 
 
|keywords=* active aging
* activity monitor
* homebound
* mobility
* walk-up buildings
|full-text-url=https://sci-hub.do/10.1177/1937586720936588
}}
{{medline-entry
|title=Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634245
 
 
|keywords=* arterial function
* arterial stiffness
* blood pressure
* early vascular aging
* pressure dependence
|full-text-url=https://sci-hub.do/10.1093/ajh/hpaa101
}}
{{medline-entry
|title=Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531126
 
|mesh-terms=* Aged
* Cardiac Surgical Procedures
* Elective Surgical Procedures
* Female
* Frailty
* Humans
* Male
* Patient Readmission
* Postoperative Complications
* Retrospective Studies
* Risk
|keywords=* adverse events
* aging
* cardiac surgery
* frailty
* rehospitalization
|full-text-url=https://sci-hub.do/10.1111/jocs.14550
}}
{{medline-entry
|title=Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546991
 
|mesh-terms=* Aged, 80 and over
* Creatinine
* Female
* Glomerular Filtration Rate
* Humans
* Kidney Function Tests
* Longevity
* Male
* Mortality
* Predictive Value of Tests
* Renal Insufficiency
* Reproducibility of Results
* Risk Factors
|keywords=* equation
* exceptional longevity
* glomerular filtration rate
* kidney function
* mortality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266309
}}
{{medline-entry
|title=Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32520344
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomass
* Body Composition
* Body Weight
* Dietary Proteins
* Female
* Humans
* Independent Living
* Male
* Muscle Development
* Muscle Strength
* Muscles
* Prospective Studies
* Sex Factors
|keywords=* appendicular lean body mass
* community-dwelling
* gait speed
* mobility limitation
* old age
* optimal intake
* physical performance
* spline functions
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326591
}}
{{medline-entry
|title=Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by [[HR]]-pQCT.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32519249
 
|mesh-terms=* Absorptiometry, Photon
* Adult
* Aged
* Aging
* Asian Continental Ancestry Group
* Bone Density
* Bone and Bones
* Cancellous Bone
* Cortical Bone
* Female
* Finite Element Analysis
* Humans
* Japan
* Linear Models
* Menopause
* Middle Aged
* Porosity
* Tomography, X-Ray Computed
|keywords=* Bone microstructure
* Estimated bone strength
* High resolution peripheral quantitative CT (HR-pQCT)
* Japanese women
* Non-metric trabecular parameter
|full-text-url=https://sci-hub.do/10.1007/s00774-020-01115-z
}}
{{medline-entry
|title=Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32492838
 
 
|keywords=* aging
* diabetes
* mortality
* nutritional support
* protein intake
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352318
}}
{{medline-entry
|title=CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32325305
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aging
* Cohort Studies
* Europe
* Humans
* Independent Living
* Male
* Middle Aged
* Mortality
* Proportional Hazards Models
* Prospective Studies
* Retirement
* Risk Factors
* Surveys and Questionnaires
|keywords=* Aging
* Comorbidity
* Depressive symptoms
* Diseases
* Mortality risk
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104035
}}
{{medline-entry
|title=Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32328003
 
 
|keywords=* arterial wave reflection
* cardiovascular biomarker
* optimum cardiovascular function
* vascular aging
* wave condition number
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161432
}}
{{medline-entry
|title=Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32333827
 
 
|keywords=*
BRCA1
 
* DNA repair
* cellular aging
* homologous recombination
* mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915
}}
{{medline-entry
|title=Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32307533
 
 
|keywords=* aging
* alertness
* balance
* blood pressure
* heart rate
* heart rate variability
* light
* sleep inertia
|full-text-url=https://sci-hub.do/10.1093/sleep/zsaa082
}}
{{medline-entry
|title=Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32300582
 
 
|keywords=* aging
* heart rate deflection
* intensity prescription
* maximal heart rate
* sex differences
* ß1-receptor sensitivity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144539
}}
{{medline-entry
|title=Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163233
 
 
|keywords=* Adverse outcomes
* Healthy aging
* Mortality
* Older adults
* Physical activity
* Trajectories
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432572
}}
{{medline-entry
|title=U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32155267
 
 
|keywords=* estradiol
* fracture
* male aging
* osteoporosis
* sex hormone-binding globulin
* testosterone
|full-text-url=https://sci-hub.do/10.1210/clinem/dgaa115
}}
{{medline-entry
|title=Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119748
 
 
|keywords=* AGING
* ANALYSIS/QUANTITATION OF BONE
* BONE QCT/μCT
* EPIDEMIOLOGY
* GENERAL POPULATION STUDIES
|full-text-url=https://sci-hub.do/10.1002/jbmr.3998
}}
{{medline-entry
|title=Analysis of the world record time for combined father and son marathon.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917623
 
 
|keywords=* V̇o2max
* aerobic exercise
* aging
* endurance
* oxygen consumption
* running
|full-text-url=https://sci-hub.do/10.1152/japplphysiol.00819.2019
}}
{{medline-entry
|title=Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31934605
 
 
|keywords=* Aging
* autonomic nervous system
* heat stress
* parasympathetic nervous system
* relative humidity
* sympathetic nervous system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949029
}}
{{medline-entry
|title=Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843945
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Benzhydryl Compounds
* Cardiovascular System
* Diabetes Mellitus, Type 2
* Diabetic Ketoacidosis
* Female
* Glucosides
* Humans
* Hypoglycemia
* Hypoglycemic Agents
* Incidence
* Kidney
* Male
* Middle Aged
* Sodium-Glucose Transporter 2 Inhibitors
* Survival Analysis
* Treatment Outcome
* Urinary Tract Infections
 
|full-text-url=https://sci-hub.do/10.2337/dc19-1476
}}
{{medline-entry
|title=Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31766291
 
|mesh-terms=* Adolescent
* Aging
* Body Mass Index
* Exercise
* Exercise Test
* Female
* Heart Rate
* Humans
|keywords=* cardiac rate
* exercise prescription
* exercise testing
* prediction equations
* training zones
* volleyball
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915545
}}
{{medline-entry
|title=Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31782607
 
|mesh-terms=* Adipose Tissue
* Adult
* Aging
* DNA Breaks, Double-Stranded
* DNA End-Joining Repair
* DNA Repair
* Humans
* Middle Aged
* Recombinational DNA Repair
* Stem Cells
* Up-Regulation
* X-ray Repair Cross Complementing Protein 1
* Young Adult
|keywords=* XRCC1
* adipose-derived stem cells
* base excision repair
* genome integrity
* human aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996963
}}
{{medline-entry
|title=Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31768493
 
 
|keywords=* AGING
* EPIDEMIOLOGY
* GENERAL POPULATION STUDIES
* OSTEOPOROSIS
* STATISTICAL METHODS
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874178
}}
{{medline-entry
|title=Malnutrition as a Strong Predictor of the Onset of Sarcopenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783482
 
|mesh-terms=* Aged
* Aging
* Cohort Studies
* Female
* Humans
* Independent Living
* Male
* Malnutrition
* Proportional Hazards Models
* Prospective Studies
* Risk Factors
* Sarcopenia
|keywords=* EWGSOP2
* GLIM
* SarcoPhAge
* malnutrition
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950107
}}
{{medline-entry
|title=Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31776883
 
 
|keywords=* Aging
* Cardiac autonomic modulation
* Heart rate
* Heart rate variability
* Thermoneutrality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031176
}}
{{medline-entry
|title=Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736136
 
|mesh-terms=* Aged
* Apolipoproteins E
* Cognitive Dysfunction
* Dementia
* Female
* Follow-Up Studies
* Genetic Predisposition to Disease
* Humans
* Life Style
* Male
* Protective Factors
* Risk Assessment
* Risk Factors
|keywords=* cognitive aging
* cohort study
* dementia
* epidemiology
* lifestyle
* prevention
* risk factors
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003764
}}
{{medline-entry
|title=Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754754
 
 
|keywords=* Aging
* Bone mineral density
* Chronic kidney disease
* Estimated glomerular filtration rate
* Fracture
* Women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946753
}}
{{medline-entry
|title=Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31653645
 
|mesh-terms=* Age of Onset
* Aged
* Aging
* Biomarkers
* Cohort Studies
* DNA
* DNA Damage
* Diabetes Mellitus, Type 2
* Dinoprost
* Female
* Follow-Up Studies
* Germany
* Humans
* Incidence
* Lipid Peroxidation
* Male
* Middle Aged
* Oxidation-Reduction
* Oxidative Stress
* RNA
 
|full-text-url=https://sci-hub.do/10.2337/dc19-1379
}}
{{medline-entry
|title=Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31548909
 
 
|keywords=* cardio-protection
* exercise
* longevity
* non-communicable diseases
* physical activity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733336
}}
{{medline-entry
|title=Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31557538
 
|mesh-terms=* Adult
* Aged
* Aging
* Blood Pressure
* Brain
* Cerebrovascular Circulation
* Female
* Heart Rate
* Humans
* Hypoxia
* Male
* Pulmonary Ventilation
* Ultrasonography, Doppler, Transcranial
* Young Adult
|keywords=* Aging
* Arterial oxygen saturation
* Cerebral blood flow
* Cerebral tissue oxygenation
* Heart rate
* Hypoxemia
* Ventilation
|full-text-url=https://sci-hub.do/10.1016/j.resp.2019.103306
}}
{{medline-entry
|title=Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31513442
 
|mesh-terms=* Aging
* Bilateral Vestibulopathy
* Female
* Humans
* Male
* Middle Aged
* Reflex, Abnormal
* Sympathetic Nervous System
|keywords=* bilateral vestibular loss
* compensation
* multisensory integration
* otolithic system
* vestibulo-sympathetic reflex
|full-text-url=https://sci-hub.do/10.1152/japplphysiol.00466.2019
}}
{{medline-entry
|title=Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31496136
 
|mesh-terms=* Animals
* Autonomic Nervous System
* Blood Pressure
* Circadian Rhythm
* Down Syndrome
* Heart Rate
* Male
* Mice
* Mice, Inbred C57BL
* Vascular Stiffness
|keywords=* Aging
* arterial stiffness
* autonomic nervous system
* circadian
* pulse wave velocity
* spectral analysis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732568
}}
{{medline-entry
|title=Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500653
 
|mesh-terms=* Adipose Tissue
* Animals
* Body Composition
* Body Weight
* Dogs
* Longevity
* Longitudinal Studies
* Survival Analysis
|keywords=* Cohort
* Cox
* DEXA
* Dogs
* Fat mass
* Healthspan
* Lean mass
* Lean to fat ratio
* Longevity
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734441
}}
{{medline-entry
|title=Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31464406
 
|mesh-terms=* Aged
* Aged, 80 and over
* Asian Continental Ancestry Group
* Diet
* Female
* Health Surveys
* Humans
* Indigenous Peoples
* Longevity
* Male
* Mortality
* Nutrition Surveys
* Nutritional Status
* Risk Factors
* Taiwan
 
|full-text-url=https://sci-hub.do/10.6133/apjcn.201909_28(3).0019
}}
{{medline-entry
|title=Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31455442
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Cognitive Dysfunction
* Dementia
* Exercise
* Female
* Heart Failure
* Heterozygote
* Humans
* Hypertension
* Male
* Pennsylvania
* Proportional Hazards Models
* Prospective Studies
* Risk Factors
* Stroke
|keywords=* Alzheimer‘s disease (AD)
* apolipoprotein E (APOE)
* cerebral vascular disease (CVD)
* dementia
* epidemiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948010
}}
{{medline-entry
|title=Work Ability and Job Survival: Four-Year Follow-Up.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31466415
 
|mesh-terms=* Adult
* Brazil
* Employment
* Female
* Follow-Up Studies
* Hospitals
* Humans
* Male
* Proportional Hazards Models
* Work Capacity Evaluation
|keywords=* aging
* healthcare worker
* life course
* longitudinal studies
* prolonged work career
* work ability
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747402
}}
{{medline-entry
|title=Predictivity of bioimpedance phase angle for incident disability in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31436391
 
 
|keywords=* Aging
* Body composition
* Cellular health
* Muscle mass
* Nutrition
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015240
}}
==HRAS==
 
{{medline-entry
|title=How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32245376
 
|mesh-terms=* Adult
* Alcohol Drinking
* Attitude to Health
* Cluster Analysis
* Diagnostic Self Evaluation
* Diet, Healthy
* Exercise
* Female
* Health Risk Behaviors
* Humans
* Life Expectancy
* Life Style
* Logistic Models
* Male
* Middle Aged
* Netherlands
* Prevalence
* Sedentary Behavior
* Smoking
* Surveys and Questionnaires
* Young Adult
|keywords=* Clustering risk attitude
* Health behaviours
* Subjective health
* Time orientation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126128
}}
{{medline-entry
|title=Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31940439
 
 
|keywords=* proteoform
* quantitative proteomics
* secretome
* senescence
* top-down proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032038
}}
==HS2ST1==
 
{{medline-entry
|title=Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31940721
 
|mesh-terms=* Animals
* Avian Proteins
* Birds
* Endangered Species
* Immunity
* Longevity
* Polymorphism, Genetic
* Species Specificity
* Transcriptome
* Whole Genome Sequencing
|keywords=* genome
* longevity
* red-crowned crane
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999708
}}
==HSF1==
 
{{medline-entry
|title=A Mitochondrial Stress-Specific Form of [[HSF1]] Protects against Age-Related Proteostasis Collapse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735771
 
 
|keywords=* HSF1
* PP2A
* aging
* mitochondria
* molecular chaperones
* protein aggregation
* proteostasis
* stress responses
|full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.06.038
}}
{{medline-entry
|title=Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31627188
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Heat Shock Transcription Factors
* High-Temperature Requirement A Serine Peptidase 2
* Male
* Mice
* Mice, Inbred C57BL
* Mitochondria, Heart
* Myocytes, Cardiac
* NIH 3T3 Cells
* Transcriptional Activation
* Up-Regulation
|keywords=* Omi/HtrA2
* age-related pathology
* cardiovascular
* mitochondria
* transcriptional regulation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834417
}}
{{medline-entry
|title=Multifactorial Attenuation of the Murine Heat Shock Response With Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612204
 
 
|keywords=* Aging
* HSF1
* Stress
|full-text-url=https://sci-hub.do/10.1093/gerona/glz204
}}
==HSPA1A==
 
{{medline-entry
|title=Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566824
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Apoptosis
* Cholecalciferol
* Epididymis
* Male
* Rats
* Rats, Wistar
* Spermatozoa
|keywords=* aging
* apoptosis
* oxidative stress
* sperm
|full-text-url=https://sci-hub.do/10.1002/mrd.23280
}}
==HSPA1L==
 
{{medline-entry
|title=Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the [[HSPA1L]]-mitophagy pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31965731
 
 
|keywords=* HSPA1L
* melatonin
* mesenchymal stem cells
* mitochondria
* mitophagy
* replicative senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059143
}}
==HTT==
 
{{medline-entry
|title=Biological Aging and the Cellular Pathogenesis of Huntington's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417788
 
 
|keywords=* Biological aging
* DNA damage
* Huntington’s disease
* cellular aging
* microsatellite instability
* neurodegeneration
* oxidative stress
* proteostasis
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369111
}}
==ICE1==
 
{{medline-entry
|title=ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783407
 
 
|keywords=* ATBS1-INTERACTING FACTOR 2 (AIF2)
* Arabidopsis
* C-REPEAT BINDING FACTOR (CBF)
* INDUCER OF CBF EXPRESSION 1 (ICE1)
* PHYTOCHROME-INTERACTING FACTORS (PIFs)
* basic helix–loop–helix (bHLH)
* brassinosteroid (BR)
* leaf senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031079
}}
==IDE==
 
{{medline-entry
|title=Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32538851
 
 
|keywords=* Aging
* Dendrobium nobile Lindl. alkaloid (DNLA)
* amyloid-β
* autophagy
* metformin
* senescence accelerated mouse prone 8 (SAMP8)
|full-text-url=https://sci-hub.do/10.3233/JAD-200308
}}
==IDH2==
 
{{medline-entry
|title=Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31503005
 
|mesh-terms=* Animals
* Cellular Senescence
* Cyclin-Dependent Kinase 2
* Cyclin-Dependent Kinase Inhibitor p21
* Embryo, Mammalian
* Fibroblasts
* Isocitrate Dehydrogenase
* Mice
* Mice, Knockout
* NIH 3T3 Cells
* Reactive Oxygen Species
|keywords=* cell cycle
* cyclin-dependent kinase 2 (Cdk2)
* isocitrate dehydrogenase 2 (IDH2)
* reactive oxygen species (ROS)
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756887
}}
==IDS==
 
{{medline-entry
|title=Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32957211
 
 
|keywords=* Aging
* Ceramic
* Fracture strength
* Immediate dentin sealing
* Inlay
* Overlay
|full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2020.103906
}}
==IFI27==
 
{{medline-entry
|title=Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33151171
 
 
|keywords=* epidermis
* keratinocytes
* reactive oxygen species
* senescence
* skin aging
* ultraviolet radiation
|full-text-url=https://sci-hub.do/10.2478/acph-2021-0011
}}
==IGF1==
 
{{medline-entry
|title=Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33105070
 
 
|keywords=* IGF1
* antagonistic gene
* female sexual maturation
* lifespan variation
* maximum lifespan
* sex difference in lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681063
}}
{{medline-entry
|title=17α-estradiol modulates [[IGF1]] and hepatic gene expression in a sex-specific manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32857104
 
 
|keywords=* 17α-estradiol
* aging
* growth hormone
* insulin
* insulin-like growth factor-1
* liver
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa215
}}
{{medline-entry
|title=Pan-mammalian analysis of molecular constraints underlying extended lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32043462
 
 
|keywords=* RERconverge
* computational biology
* evolution
* genetics
* genomics
* longevity
* mammals
* phylogenomics
* systems biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012612
}}
{{medline-entry
|title=17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698046
 
 
|keywords=* Follicles
* Ovarian aging
* Ovarian reserve
* Reproductive lifespan
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911620
}}
==IGF1R==
 
{{medline-entry
|title=Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707439
 
 
|keywords=* Aging mice
* Hair growth
* Mitochondrial transplantation
* Pep-1
* Platelet-rich plasma
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2020.110520
}}
==IGFBP1==
 
{{medline-entry
|title=Role of [[IGFBP1]] in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545483
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Atherosclerosis
* Cells, Cultured
* Cellular Senescence
* Coronary Artery Disease
* Coronary Vessels
* Down-Regulation
* Endothelial Cells
* Female
* Humans
* Insulin-Like Growth Factor Binding Protein 1
* Jagged-1 Protein
* Male
* Middle Aged
* Signal Transduction
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777673
}}
==IGFBP2==
 
{{medline-entry
|title=Intracellular Insulin-like growth factor binding protein 2 ([[IGFBP2]]) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32302288
 
 
|keywords=* insulin-like growth factor binding protein 2
* keratinocytes
* p21CIP1/WAF1
* psoriasis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202509
}}
==IGFBP3==
 
{{medline-entry
|title=Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32489700
 
 
|keywords=* CCL11
* GDF11
* IGF1
* IGFBP
* aging
* pseudoxanthoma elasticum
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220280
}}
{{medline-entry
|title=Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31951594
 
 
|keywords=* IGFBP3
* endocytosis
* endometrial stem cells
* paracrine senescence
* secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053595
}}
==IGFBP4==
 
{{medline-entry
|title=Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31601169
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Cognition
* Female
* Gene Expression Regulation
* Gene Regulatory Networks
* Haplorhini
* Humans
* Insulin-Like Growth Factor Binding Protein 4
* Male
* Mice
* Proteomics
|keywords=* Cognitive dysfunction
* IGFBP4
* Plasma
* Quantitative proteomics
* iTRAQ
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788010
}}
==IGFBP7==
 
{{medline-entry
|title=Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904196
 
 
|keywords=* IGFBP7
* IL-6
* human fibroblast
* osteoblast
* reprogramming
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031646
}}
==IHH==
 
{{medline-entry
|title=Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32235006
 
 
|keywords=* Indian hedgehog
* aging
* differentiation
* mammalian target of rapamycin
* mesenchymal stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185126
}}
==IL10==
 
{{medline-entry
|title=The beneficial effect of physical exercise on inflammatory makers in older individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504508
 
 
|keywords=* IL-6 expression
* Inflammatory markers
* aerobic exercise
* aging
* plasma IL-6 levels
* resistance training
|full-text-url=https://sci-hub.do/10.2174/1871530320666200606225357
}}
{{medline-entry
|title=Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654269
 
|mesh-terms=* Aged
* Alternative Splicing
* Astrocytes
* Cells, Cultured
* Cellular Senescence
* Cognitive Dysfunction
* Cytokines
* Gene Expression
* Glial Fibrillary Acidic Protein
* Humans
* Matrix Metalloproteinases
* Transcription, Genetic
* Tumor Suppressor Protein p14ARF
* tau Proteins
|keywords=* Alternative splicing
* Gene expression
* Neurodegenerative disease
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885035
}}
{{medline-entry
|title=Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562503
 
|mesh-terms=* Animals
* Cognition Disorders
* Encephalitis
* Male
* Mice
* Oxidative Stress
* Plasma
* Swine
|keywords=* aging
* cognitive decline
* dietary supplementation
* neuroinflammation
* spray-dried animal plasma
|full-text-url=https://sci-hub.do/10.1093/jn/nxz239
}}
==IL15==
 
{{medline-entry
|title=Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of [[IL15]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221610
 
 
|keywords=* T cells
* ageing
* immune senescence
* older people
* physical activity
|full-text-url=https://sci-hub.do/10.1093/ageing/afaa035
}}
==IL1A==
 
{{medline-entry
|title=IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099841
 
 
|keywords=* CCL2
* cellular senescence
* inflammaging
* senescence-associated secretory phenotype
|full-text-url=https://sci-hub.do/10.1111/aji.13365
}}
==IL2==
 
{{medline-entry
|title=Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193368
 
 
|keywords=* IL2
* aging
* invariant natural killer T cells
* thymus
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662090
}}
==IL6==
 
{{medline-entry
|title=Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645207
 
|mesh-terms=* Adaptive Immunity
* Aged
* Antirheumatic Agents
* COVID-19
* Comorbidity
* Coronavirus Infections
* Disease Outbreaks
* Female
* Humans
* Hydroxychloroquine
* Immunity, Innate
* Immunologic Factors
* Immunosuppressive Agents
* Italy
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* Rheumatic Diseases
* Risk Assessment
* Severe Acute Respiratory Syndrome
|keywords=* COVID-19
* SARS-CoV-2
* geriatrics
* pathophysiology
* pediatrics
* rheumatology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404583
}}
{{medline-entry
|title=ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32621937
 
 
|keywords=* ATM
* Ataxia-telangiectasia
* Autophagy
* Mitophagy
* Neural progenitors
* Oxidative stress
* Senescence
* hiPSCs
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111296
}}
{{medline-entry
|title=The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32585876
 
 
|keywords=* IL6
* SASP
* VSMCs
* inflammaging
* senescence
* vascular calcification
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352675
}}
{{medline-entry
|title=Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545261
 
 
|keywords=* Streptococcus pneumoniae
* aging
* influenza
* vaccine effectiveness
* viral immune imprinting
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349919
}}
{{medline-entry
|title=Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32514870
 
 
|keywords=* Aging
* Biomarker
* Cognition
* Neuropsychology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525612
}}
{{medline-entry
|title=Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31731674
 
|mesh-terms=* Biliary Tract
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Cholestenones
* Epithelial-Mesenchymal Transition
* Histone Deacetylase 6
* Humans
* Interleukin-6
* Signal Transduction
* Stem Cells
* Tissue Donors
|keywords=* BMP pathway
* SHH pathway
* biliary tree stem/progenitor cells (BTSCs)
* epithelial-to-mesenchymal transition (EMT)
* primary sclerosing cholangitis (PSC)
* senescence
* telomerase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912632
}}
{{medline-entry
|title=Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389140
 
|mesh-terms=* Adipose Tissue, Brown
* Animals
* Cellular Senescence
* Female
* Longevity
* Male
* Mice
* Ovarian Follicle
* Ovary
* Rats
* Rats, Sprague-Dawley
* Transplantation, Heterologous
|keywords=* aging
* brown adipose tissue (BAT)
* lifespan
* mice
* ovary
* rat
* xenotransplant
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826128
}}
==ILDR1==
 
{{medline-entry
|title=Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31645637
 
|mesh-terms=* Aging
* Animals
* Auditory Pathways
* Female
* Gene Expression Regulation
* Genetic Loci
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Hearing Loss
* Humans
* Male
* Mice
* Middle Aged
* Molecular Sequence Annotation
* Phenotype
* Reproducibility of Results
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811684
}}
==IMPACT==
 
{{medline-entry
|title=Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141460
 
 
|keywords=* EEG
* alpha oscillations
* cognitive aging
* working memory
|full-text-url=https://sci-hub.do/10.1111/psyp.13719
}}
{{medline-entry
|title=Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-[[IMPACT]] Pilot.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228299
 
 
|keywords=* Telehealth
* aging
* care coordination
* home care
* interdisciplinary
* medicine
* older adult
* video
|full-text-url=https://sci-hub.do/10.1080/07317115.2020.1738000
}}
{{medline-entry
|title=AGING, HEART RATE VARIABILITY AND METABOLIC [[IMPACT]] OF OBESITY.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31969754
 
|mesh-terms=* Aging
* Autonomic Nervous System
* Autonomic Nervous System Diseases
* Female
* Heart Rate
* Humans
* Male
* Metabolic Diseases
* Metabolism
* Middle Aged
* Obesity
|keywords=* Aging
* Autonomic nervous system
* Heart rate
* Obesity, metabolically benign
* Parasympathetic nervous system
* Sympathetic nervous system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971797
}}
==INS==
 
{{medline-entry
|title=Melatonin protects [[INS]]-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32673151
 
 
|keywords=* Melatonin
* Senescence
* glucolipotoxicity
* glucotoxicity
* pancreatic β-cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527021
}}
{{medline-entry
|title=Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473187
 
|mesh-terms=* Animals
* Blotting, Western
* Calcium
* Cellular Senescence
* Diabetes Mellitus, Type 2
* Disease Progression
* Dose-Response Relationship, Drug
* Enzyme-Linked Immunosorbent Assay
* Glucose
* Insulin-Secreting Cells
* Male
* Mice
* Mice, Inbred C57BL
* Nicotine
* Reactive Oxygen Species
* Real-Time Polymerase Chain Reaction
* beta-Galactosidase
|keywords=* ROS
* islet β cells
* nicotine
* senescence
* type 2 diabetes
|full-text-url=https://sci-hub.do/10.1016/j.tox.2020.152502
}}
==INSL3==
 
{{medline-entry
|title=Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083267
 
 
|keywords=* Androgen deficiency in aging male
* arizona sexual experience scale
* hypothyroidism
* inhibin B
* insulin-like factor 3
* semen analysis
* sperm motility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539029
}}
==IP6K1==
 
{{medline-entry
|title=The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552262
 
 
|keywords=* Akt
* IP6K1
* aging
* anabolic resistance
* mTOR
* protein
* resistance exercise
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746962
}}
==IQGAP1==
 
{{medline-entry
|title=[[IQGAP1]]-dysfunction leads to induction of senescence in human vascular smooth muscle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592713
 
 
|keywords=* Cellular bridges (CBs)
* IQGAP1
* Intercellular communication
* Senescence
* Tunneling nanotubes (TNTs)
* Vascular smooth muscle cells (VSMCs)
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111295
}}
{{medline-entry
|title=Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068317
 
 
|keywords=* F-HABP07
* HABP1
* IQGAP1
* senescence
|full-text-url=https://sci-hub.do/10.1002/cbin.11326
}}
==IRF8==
 
{{medline-entry
|title=[[IRF8]] induces senescence of lung cancer cells to exert its tumor suppressive function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594449
 
|mesh-terms=* A549 Cells
* Animals
* Carcinogenesis
* Carcinoma, Non-Small-Cell Lung
* Cell Movement
* Cell Proliferation
* Cellular Senescence
* Gene Expression Regulation, Neoplastic
* Heterografts
* Humans
* Interferon Regulatory Factors
* Mice
* Prognosis
* Signal Transduction
* Tumor Suppressor Proteins
|keywords=* IRF8
* NSCLC
* cell cycle arrest
* cell senescence
* tumor suppresser gene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927690
}}
==IRS1==
 
{{medline-entry
|title=MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056304
 
 
|keywords=* CERK
* aging muscle
* insulin signaling pathway
* miR-34a
|full-text-url=https://sci-hub.do/10.1002/jcb.29312
}}
{{medline-entry
|title=Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31721422
 
 
|keywords=* IGF
* aging
* autophagy
* insulin
* lifespan
* metabolism
* polyamine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974722
}}
{{medline-entry
|title=Serine Phosphorylation of [[IRS1]] Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31426549
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Amyloid beta-Protein Precursor
* Animals
* Brain
* Diabetes Mellitus, Type 2
* Humans
* Insulin
* Insulin Receptor Substrate Proteins
* Male
* Memory
* Memory Disorders
* Mice, Inbred C57BL
* Mice, Transgenic
* Phosphorylation
* Serine
* Signal Transduction
|keywords=* AMPK
* Alzheimer’s disease
* Aβ
* IRS1
* aging
* diabetes
* energy depletion
* hippocampus
* memory decline
* serine phosphorylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723493
}}
==IRS2==
 
{{medline-entry
|title=Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264567
 
 
|keywords=* IGF1
* IGFBP3
* INSR
* IRS1
* IRS2
* Male reproduction
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717869
}}
==ITGA3==
 
{{medline-entry
|title=A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32807231
 
 
|keywords=* AKT
* Culture-aged
* ECM-receptor protein
* Integrin α3
* Senescence
* Serial passaging
* Tonsil-derived mesenchymal stem cells
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430027
}}
==ITGA5==
 
{{medline-entry
|title=Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31486245
 
|mesh-terms=* Animals
* Blastocyst
* Cellular Senescence
* Embryo Culture Techniques
* Embryo, Mammalian
* Embryonic Development
* Female
* Integrins
* Kaempferols
* Mitochondria
* Nanog Homeobox Protein
* Octamer Transcription Factor-3
* Oocytes
* Oxidative Stress
* RNA, Messenger
* Reactive Oxygen Species
* Swine
|keywords=* embryonic development
* kaempferol
* oocyte aging
* porcine
|full-text-url=https://sci-hub.do/10.1111/asj.13280
}}
==ITGAM==
 
{{medline-entry
|title=Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31732940
 
|mesh-terms=* Aging
* Animals
* Disease Models, Animal
* Epithelial Cells
* Gingiva
* Macaca mulatta
* Oligonucleotide Array Sequence Analysis
* Transcriptome
 
|full-text-url=https://sci-hub.do/10.1007/978-3-030-28524-1_11
}}
==IVD==
 
{{medline-entry
|title=MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32443722
 
 
|keywords=* ECM
* MMP
* annulus fibrosus
* cartilaginous endplate
* degenerative disc disease
* miRNA
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279351
}}
{{medline-entry
|title=A step-by-step protocol for isolation of murine nucleus pulposus cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31891122
 
 
|keywords=* aging
* gene expression
* intervertebral disc degeneration
* nucleus pulposus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920701
}}
{{medline-entry
|title=Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852919
 
|mesh-terms=* Aging
* Animals
* Annulus Fibrosus
* Apoptosis
* Biomarkers
* Carcinogenesis
* Caspase 3
* Cell Count
* Extracellular Matrix
* Intervertebral Disc
* Intervertebral Disc Degeneration
* Mice, Inbred C57BL
* Mice, Knockout
* Nucleus Pulposus
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920379
}}
{{medline-entry
|title=Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31690186
 
|mesh-terms=* Aging
* Animals
* Back Pain
* Disease Models, Animal
* Finite Element Analysis
* Humans
* Intervertebral Disc
* Movement
* Weight-Bearing
* Zebrafish
|keywords=* deformation
* finite element
* geometric morphometrics
* mechanics
* spine
* zebrafish
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893493
}}
{{medline-entry
|title=Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473842
 
|mesh-terms=* Adult
* Age Factors
* Aging
* Analysis of Variance
* Biomechanical Phenomena
* Body Height
* Body Mass Index
* Body Weight
* Cortical Bone
* Female
* Finite Element Analysis
* Humans
* Imaging, Three-Dimensional
* Intervertebral Disc
* Lumbar Vertebrae
* Male
* Models, Biological
* Range of Motion, Articular
* Risk Factors
* Sex Characteristics
|keywords=* Age
* Biomechanics
* Body mass index (BMI)
* Finite element method (FEM)
* Functional spinal unit (FSU)
* Height
* Response surface method (RSM)
* Sex
* Weight
|full-text-url=https://sci-hub.do/10.1007/s10237-019-01215-4
}}
{{medline-entry
|title=In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31463468
 
 
|keywords=* Contrast‐enhanced microCT
* aging
* intervertebral disc
* mouse model
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686789
}}
==JAK1==
 
{{medline-entry
|title=Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233952
 
|mesh-terms=* Bone Resorption
* Cell Cycle Checkpoints
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* DNA Damage
* Gene Expression Regulation, Developmental
* Histones
* Humans
* Janus Kinase 1
* Mesenchymal Stem Cells
* Mitochondria
* Osteogenesis
* Paracrine Communication
* Radiation
* Reactive Oxygen Species
* STAT3 Transcription Factor
* Signal Transduction
|keywords=* SASP
* bone marrow mesenchymal stem cells
* cellular senescence
* irradiation
* osteogenic differentiation
|full-text-url=https://sci-hub.do/10.1152/ajpcell.00520.2019
}}
{{medline-entry
|title=The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through [[JAK1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396213
 
|mesh-terms=* Autocrine Communication
* Cellular Senescence
* Fetal Blood
* Humans
* Interleukin-6
* Janus Kinase 1
* Mesenchymal Stem Cells
* Toll-Like Receptor 3
* Up-Regulation
|keywords=* Janus kinase 1 (JAK1)
* Toll-like receptor 3 (TLR3)
* interferon-β (IFN-β)
* mesenchymal stromal cell (MSC)
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665952
}}
==JAK2==
 
{{medline-entry
|title=Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850477
 
 
|keywords=* DC-SIGN
* IL-10
* dengue virus
* monocytes
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399640
}}
{{medline-entry
|title=Quercetin Directly Targets [[JAK2]] and PKCδ and Prevents UV-Induced Photoaging in Human Skin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31652815
 
|mesh-terms=* Antioxidants
* Cell Line
* Cells, Cultured
* Cyclooxygenase 2
* Humans
* Janus Kinase 2
* MAP Kinase Signaling System
* Matrix Metalloproteinase 1
* NF-kappa B
* Protein Kinase C-delta
* Quercetin
* STAT3 Transcription Factor
* Skin
* Skin Aging
* Transcription Factor AP-1
* Ultraviolet Rays
|keywords=* JAK2
* PKC-delta
* quercetin
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862686
}}
{{medline-entry
|title=[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594177
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Breath Tests
* Carbon Monoxide
* Case-Control Studies
* Erythrocyte Count
* Erythrocytes
* Female
* Humans
* Janus Kinase 2
* Longevity
* Male
* Middle Aged
* Polycythemia Vera
|keywords=* Carbon monoxide breath test
* Polycythemia vera
* Red blood cell lifespan
|full-text-url=https://sci-hub.do/10.3760/cma.j.issn.0578-1426.2019.10.010
}}
{{medline-entry
|title=Roles of [[JAK2]] in Aging, Inflammation, Hematopoiesis and Malignant Transformation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398915
 
|mesh-terms=* Aging
* Animals
* Hematopoiesis
* Humans
* Inflammation
* Janus Kinase 2
* Mice
* Myeloproliferative Disorders
* Neoplasms
|keywords=* JAK2
* Janus-kinase
* aging
* clonal hematopoiesis (CHIP), myeloproliferative neoplasia (MPN)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721738
}}
==JUN==
 
{{medline-entry
|title=Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794717
 
|mesh-terms=* Actin Cytoskeleton
* Actins
* Aging
* Animals
* Binding Sites
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Intercellular Junctions
* Intestinal Mucosa
* JNK Mitogen-Activated Protein Kinases
* Phosphorylation
* Protein Phosphatase 1
* Transcription Factors
* Troponin
|keywords=* HSF-1
* actin
* aging
* barrier
* intestine
* junctions
* kinase
* pathogenesis
* phosphorylation
* stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897307
}}
==JUNB==
 
{{medline-entry
|title=Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of [[JUNB]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31806366
 
|mesh-terms=* Cell Line, Tumor
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Gene Expression Regulation, Neoplastic
* Gene Knockout Techniques
* HEK293 Cells
* Humans
* Transcription Factors
* Transcription, Genetic
* Up-Regulation
|keywords=* Cellular senescence
* JUNB
* P21(CDKN1A)
* THG-1(TSC22D4)
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.11.145
}}
==KAT6B==
 
{{medline-entry
|title=Aging-associated decrease in the histone acetyltransferase [[KAT6B]] is linked to altered hematopoietic stem cell differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32014431
 
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Epigenesis, Genetic
* Erythroid Cells
* Gene Expression Profiling
* Gene Expression Regulation, Enzymologic
* Gene Knockout Techniques
* Histone Acetyltransferases
* Male
* Mice
* Mice, Transgenic
* Myeloid Progenitor Cells
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179256
}}
==KCNK2==
 
{{medline-entry
|title=Brain age prediction using deep learning uncovers associated sequence variants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31776335
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Brain
* Databases, Factual
* Deep Learning
* Genome-Wide Association Study
* Humans
* Iceland
* Magnetic Resonance Imaging
* Middle Aged
* Neural Networks, Computer
* Neuropsychological Tests
* Polymorphism, Single Nucleotide
* United Kingdom
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881321
}}
==KCNQ4==
 
{{medline-entry
|title=Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327991
 
 
|keywords=* KCNQ4
* PARP-1
* aging
* cGMP
* guanylyl cyclase A
* hidden hearing loss
* inner ear
* otoprotection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160671
}}
==KCTD12==
 
{{medline-entry
|title=The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970748
 
|mesh-terms=* Adult
* Demography
* Female
* Gene Expression Profiling
* Humans
* Longevity
* Male
* Metabolic Networks and Pathways
* Middle Aged
* Monocytes
* Poverty
* Transcriptome
* Urban Population
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514036
}}
==KDM2A==
 
{{medline-entry
|title=SIRT6 mono-ADP ribosylates [[KDM2A]] to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32584788
 
 
|keywords=* DNA repair
* SIRT6
* genome stability
* longevity
* transcription
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343504
}}
==KDM2B==
 
{{medline-entry
|title=Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270414
 
 
|keywords=* Lysine demethylase
* Non-methylated CpG
* Oncogene
* Polycomb repressive complex
* Replicative senescence
* Zn-finger
|full-text-url=https://sci-hub.do/10.1007/s10930-020-09895-z
}}
==KDM3A==
 
{{medline-entry
|title=[[KDM3A]] and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704649
 
 
|keywords=* Cell Biology
* DNA damage
* Molecular Mechanism of Gene Regulation
* Stem Cells Research
* bone aging
* condensin
* epigenetic regulation
* histone demethylase
* mesenchymal stromal cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888768
}}
==KEAP1==
 
{{medline-entry
|title=NRF2 pathway activation by [[KEAP1]] inhibition attenuates the manifestation of aging phenotypes in salivary glands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590331
 
 
|keywords=* Aging
* KEAP1
* Mouse
* NRF2
* Salivary glands
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322188
}}
{{medline-entry
|title=Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424161
 
|mesh-terms=* Adaptation, Physiological
* Animals
* Antioxidants
* Basal Metabolism
* Biological Evolution
* Birds
* Cell Nucleus
* Feathers
* Fibroblasts
* Genomics
* Glutathione Transferase
* HEK293 Cells
* Humans
* Kelch-Like ECH-Associated Protein 1
* Longevity
* NF-E2-Related Factor 2
* Oxidative Stress
* Phylogeny
* Proteasome Endopeptidase Complex
* Protein Binding
* Protein Transport
* Ubiquitination
* Up-Regulation
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234996
}}
==KIN==
 
{{medline-entry
|title=The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001616
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Casein Kinase I
* Heat-Shock Proteins, Small
* Longevity
* Malate Dehydrogenase
* Peptides
* Protein Aggregates
* Protein Folding
* RNA Interference
* RNA, Small Interfering
* Recombinant Proteins
|keywords=* Caenorhabditis elegans (C. elegans)
* chaperone
* protein aggregates
* protein aggregation
* protein folding
* proteostasis
* selective protein aggregase
* small heat shock protein (sHsp)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062175
}}
==KIT==
 
{{medline-entry
|title=Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-[[KIT]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223330
 
 
|keywords=* BMP15
* C-KIT
* GDF9
* Ovarian aging
* biomarkers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221484
}}
==KLF2==
 
{{medline-entry
|title=[[KLF2]] induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866399
 
|mesh-terms=* Animals
* Carcinogenesis
* Cell Cycle Proteins
* Cell Line
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Forkhead Transcription Factors
* Kruppel-Like Transcription Factors
* Male
* Mice
* Mice, Nude
* Pancreatic Neoplasms
* Protein Binding
* Up-Regulation
|keywords=* FOXO4
* KLF2
* Pancreatic cancer
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2019.111784
}}
==KLF4==
 
{{medline-entry
|title=Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630449
 
 
|keywords=* aging
* extracellular vesicles
* oxygen
* physiological oxygen concentration
* physioxia
* redox
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357081
}}
{{medline-entry
|title=Soluble klotho regulates the function of salivary glands by activating [[KLF4]] pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581134
 
|mesh-terms=* Animals
* Cells, Cultured
* Down-Regulation
* Gene Expression Regulation
* Glucuronidase
* HEK293 Cells
* Humans
* Kruppel-Like Transcription Factors
* Membrane Proteins
* Mice
* Mice, Knockout
* Nuclear Proteins
* RNA Interference
* RNA, Small Interfering
* Salivary Glands
|keywords=* KLF4
* aging
* salivary gland
* soluble klotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814581
}}
==KLF6==
 
{{medline-entry
|title=Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31824948
 
 
|keywords=* DNA damage
* KLF6
* cell proliferation
* cellular senescence
* ras oncogene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882731
}}
==KRAS==
 
{{medline-entry
|title=Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067202
 
 
|keywords=* adenosine triphosphate
* aging
* antioxidant
* apoptosis
* atherogenesis
* cancer
* carcinogenesis
* cholesterol
* free radical
* geraniol
* geranylgeraniol
* homocysteine
* menoquinone
* mitochondrial dysfunction
* mitochondrial membrane potential
* mitochondrial permeability transition pore
* mitophagy
* neuro-degeneration
* oxidative phosphorylation
* oxidative stress
* squalene
* statin
* stellate cells
* testosterone
* thioretinaco ozonide
* thioretinamide
* tocopherol
* tocotrienol
* ubiquinone
 
}}
{{medline-entry
|title=Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234521
 
|mesh-terms=* Aging
* Animals
* CD8-Positive T-Lymphocytes
* Carcinoma, Pancreatic Ductal
* Cell Line, Tumor
* Cell Proliferation
* Cyclin-Dependent Kinase 4
* Cyclin-Dependent Kinase 6
* Gene Expression Regulation, Neoplastic
* Genes, ras
* Humans
* Immunotherapy
* MAP Kinase Signaling System
* Mice
* Pancreatic Neoplasms
* Retinoblastoma Protein
* Signal Transduction
* Tumor Microenvironment
* Vascular Remodeling
|keywords=* T cells
* chemotherapy resistance
* endothelial cell activation
* immunotherapy
* pancreatic cancer
* senescence
* senescence-associated secretory phenotype
* targeted therapy
* tumor microenvironment
* vascular biology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278897
}}
==L1CAM==
 
{{medline-entry
|title=Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31510944
 
|mesh-terms=* Adenosine Triphosphatases
* Apoptosis
* Biomarkers
* Brain Neoplasms
* Cation Transport Proteins
* Cell Adhesion
* Cell Adhesion Molecules, Neuronal
* Cell Line, Tumor
* Cellular Senescence
* Gene Expression Profiling
* Gene Expression Regulation, Neoplastic
* Glioblastoma
* Humans
* Immunohistochemistry
* Neural Cell Adhesion Molecule L1
* RNA, Small Interfering
* Signal Transduction
|keywords=* AMOG
* Apoptosis
* Glioma
* Human
* L1CAM
* Senescence
* Therapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739972
}}
==LAG3==
 
{{medline-entry
|title=T Cell Transcriptional Profiling and Immunophenotyping Uncover [[LAG3]] as a Potential Significant Target of Immune Modulation in Multiple Myeloma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31445183
 
 
|keywords=* Autologous stem cell transplant
* Exhaustion
* LAG3
* Multiple myeloma
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952061
}}
==LAMP1==
 
{{medline-entry
|title=Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32579115
 
 
|keywords=* CLN3
* TREM2
* aging
* autofluorescence
* immunology
* inflammation
* lysosomal storage disorder
* microglia
* mouse
* neuroscience
* rhesus macaque
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367682
}}
==LBP==
 
{{medline-entry
|title=Lipopolysaccharide binding protein is associated with CVD risk in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895891
 
 
|keywords=* Aging
* Cardiovascular disease risk
* Intestinal permeability
* Lipopolysaccharide binding protein
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01684-z
}}
{{medline-entry
|title=Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090603
 
|mesh-terms=* Acute-Phase Proteins
* Aging
* Animals
* Apoptosis
* Biomarkers
* Carrier Proteins
* Endotoxins
* Female
* Gene Expression Regulation
* Glucose
* Inflammation
* Insulin Receptor Substrate Proteins
* Liver
* Liver Cirrhosis
* Malate Dehydrogenase
* Male
* Membrane Glycoproteins
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* RNA, Messenger
* Receptor, Insulin
* Toll-Like Receptor 4
|keywords=* Tlr-4 signaling
* aging
* bacterial endotoxin
* lipopolysaccharide binding protein
* liver degeneration
|full-text-url=https://sci-hub.do/10.1152/ajpgi.00345.2018
}}
{{medline-entry
|title=Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654268
 
|mesh-terms=* Aged
* Aging
* Biomarkers
* Exercise Therapy
* Female
* Follow-Up Studies
* Humans
* Inflammation
* Male
* Metabolic Syndrome
* Middle Aged
* Mobility Limitation
* Motor Activity
* Obesity
* Retrospective Studies
* Weight Loss
|keywords=* Ageing
* Lipopolysaccharide-binding protein
* Microbial translocation
* Physical function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925090
}}
{{medline-entry
|title=Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31615282
 
|mesh-terms=* Aging
* Amyloidogenic Proteins
* Amyloidosis
* Animals
* Antigens, Surface
* Female
* Mammary Glands, Animal
* Milk Proteins
* Plaque, Amyloid
* Rats
* Rats, Sprague-Dawley
|keywords=* Amyloidosis
* lipopolysaccharide binding protein
* mammary gland
* pathology
* rat
|full-text-url=https://sci-hub.do/10.1080/13506129.2019.1675623
}}
{{medline-entry
|title=Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583041
 
|mesh-terms=* Aging
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Drugs, Chinese Herbal
* Receptors, Cytoplasmic and Nuclear
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754959
}}
==LBR==
 
{{medline-entry
|title=Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32726434
 
 
|keywords=* Aging
* cancer
* cellular senescence
* chromatine structure
* nuclear envelop
|full-text-url=https://sci-hub.do/10.1042/BCJ20200165
}}
{{medline-entry
|title=The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173784
 
 
|keywords=* Aneuploidy
* Pregestational genetic testing
* Reproductive aging
* Single embryo transfer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125286
}}
{{medline-entry
|title=The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32126237
 
 
|keywords=* Gene expression
* LBR
* SAHF
* SASP
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111927
}}
{{medline-entry
|title=Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31825172
 
 
|keywords=* LBR
* autophagy
* proteasome
* protein accumulation
* senescence
* unbalanced growth
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996348
}}
==LEP==
 
{{medline-entry
|title=Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31943003
 
 
|keywords=* Aging
* Body mass index
* Dynapenia
* Leg extension power
* Sarcopenia
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa013
}}
{{medline-entry
|title=The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31419087
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Body Composition
* Cohort Studies
* Cross-Sectional Studies
* Denmark
* Female
* Hand Strength
* Humans
* Leg
* Longevity
* Middle Aged
* Prospective Studies
* Sarcopenia
* Young Adult
|keywords=* Body composition
* DXA
* Handgrip strength
* Lean mass
* Leg power
* Sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903448
}}
==LGR6==
 
{{medline-entry
|title=Effect of defensins-containing eye cream on periocular rhytids and skin quality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32614135
 
 
|keywords=* aging
* defensins
* periocular
* rhytids
* skin
|full-text-url=https://sci-hub.do/10.1111/jocd.13424
}}
==LHCGR==
 
{{medline-entry
|title=Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33050653
 
 
|keywords=* aging rats
* diabetes mellitus
* human chorionic gonadotropin
* low-molecular-weight agonist
* luteinizing hormone receptor
* spermatogenesis
* steroidogenesis
* testes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590010
}}
==LMNA==
 
{{medline-entry
|title=Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187870
 
 
|keywords=* Inflammation and cellular senescence
* Insulin resistance
* LMNA/C transcript variants
* Mononuclear cells
* Type 2 diabetes mellitus
|full-text-url=https://sci-hub.do/10.1016/j.jdiacomp.2020.107758
}}
{{medline-entry
|title=Protein structural and mechanistic basis of progeroid laminopathies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799420
 
 
|keywords=* 3D structure
* aging disorders
* contact sites
* lamin
* nuclear structure
|full-text-url=https://sci-hub.do/10.1111/febs.15526
}}
{{medline-entry
|title=Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32408587
 
 
|keywords=* Hutchinson–Gilford progeria syndrome
* LMNA
* aging
* atherosclerosis
* endothelial dysfunction
* inflammation
* lamin A
* prenylation
* progerin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406
}}
{{medline-entry
|title=The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196928
 
 
|keywords=* JAK/STAT pathway
* cellular senescence
* progeria
* ruxolitinib
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189991
}}
{{medline-entry
|title=Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048129
 
 
|keywords=* Aging
* Extracellular vesicles
* Hutchinson–Gilford progeria syndrome
* Progerin
* Stem cells
* Therapeutics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205988
}}
{{medline-entry
|title=Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794853
 
 
|keywords=* Aging
* Animal model breeding
* Bone strength
* Hutchinson-Gilford Progeria Syndrome (HGPS)
* Kyphosis
* Quality of life
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110784
}}
==LMNB1==
 
{{medline-entry
|title=SIRT1 - a new mammalian substrate of nuclear autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33292048
 
 
|keywords=* Aging
* SIRT1
* nuclear autophagy
* senescence
* sirtuin
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1860541
}}
{{medline-entry
|title=Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279583
 
 
|keywords=* alpha tubulin
* cellular senescence
* mesothelial cells
* microarray analysis
* multiwalled carbon nanotubes
* γH2A.X
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111412
}}
{{medline-entry
|title=Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32523550
 
 
|keywords=* aging
* cardiovascular
* inflammation
* senescence
* smooth muscle cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261939
}}
==LOX==
 
{{medline-entry
|title=12-[[LOX]] catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32161117
 
 
|keywords=* 2-arachidonoyl-lysophospholipids
* aging
* calcium
* eicosanoid
* iPLA2γ
* lysophospholipid
* myocardium
* platelet
* platelet-type 12-lipoxygenase (12-LOX)
* polyunsaturated fatty acids (PUFAs)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170522
}}
==LOXL1==
 
{{medline-entry
|title=A blackberry-dill extract combination synergistically increases skin elasticity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583541
 
 
|keywords=* blackberry-dill
* elasticity
* skin aging
* skin physiology/structure
* skin repair
|full-text-url=https://sci-hub.do/10.1111/ics.12644
}}
==LOXL2==
 
{{medline-entry
|title=Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31569601
 
|mesh-terms=* Adenoviridae
* Aging
* Amino Acid Oxidoreductases
* Animals
* Arthritis, Experimental
* Cartilage, Articular
* Disease Models, Animal
* Disease Progression
* Gene Expression
* Gene Transfer Techniques
* Genetic Vectors
* Interleukin-1beta
* Mice
* Mice, Transgenic
* NF-kappa B
* Osteoarthritis, Knee
* Transduction, Genetic
|keywords=* Lysyl oxidase like-2
* adenovirus delivery
* anabolic response
* articular cartilage
* knee joint
* osteoarthritis
* regeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801581
}}
==LPA==
 
{{medline-entry
|title=Ginseng gintonin, aging societies, and geriatric brain diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817818
 
 
|keywords=* Brain aging
* Gintonin
* Neurodegenerative diseases
* Panax ginseng
* Rejuvenation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426447
}}
{{medline-entry
|title=Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442243
 
 
|keywords=* cognitive aging
* depression
* frailty
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa110
}}
{{medline-entry
|title=Does sedentary time increase in older adults in the days following participation in intense exercise?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32130714
 
|mesh-terms=* Accelerometry
* Aged
* Exercise
* Exercise Test
* Humans
* Sedentary Behavior
* Sleep
|keywords=* Aging
* Compensation
* High intensity
* Movement behaviours
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01502-6
}}
{{medline-entry
|title=Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32108890
 
|mesh-terms=* Aged
* Case-Control Studies
* Cross-Sectional Studies
* Female
* Humans
* Lipoprotein(a)
* Longevity
* Male
* Mendelian Randomization Analysis
* Middle Aged
* Parents
* Phenotype
* Prospective Studies
* Risk Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049087
}}
{{medline-entry
|title=Elevated Autotaxin and [[LPA]] Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769428
 
 
|keywords=* Aging
* Autotaxin
* Hepatitis
* Hepatocellular Carcinoma
* Immune Activation
* Immunity
* Inflammation
* Liver
* Lysophosphatidic Acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966516
}}
{{medline-entry
|title=Lysophosphatidic acid receptor [[LPA]]  prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31714004
 
 
|keywords=* 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate
* Hutchinson-Gilford progeria syndrome
* LPA3
* cell senescence
* lysophosphatidic acid
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974717
}}
{{medline-entry
|title=Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656243
 
 
|keywords=* accelerometry
* aging
* exercise
* neurocognitive disorders
* sedentary lifestyle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557173
}}
{{medline-entry
|title=Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612759
 
 
|keywords=* White matter hyperintensity
* brain aging
* cerebral small vessel disease
* lesion segmentation
* methodology
* validation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607266
}}
{{medline-entry
|title=The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581429
 
|mesh-terms=* Accelerometry
* Aged
* Aged, 80 and over
* Aging
* Body Mass Index
* Cross-Sectional Studies
* Exercise
* Female
* Humans
* Male
* Physical Fitness
* Sedentary Behavior
|keywords=* accelerometry
* ageing
* health
* physical fitness
* sedentary behaviour
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801920
}}
{{medline-entry
|title=Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600755
 
|mesh-terms=* Aged
* Cardiovascular Diseases
* Cohort Studies
* Exercise
* Female
* Follow-Up Studies
* Humans
* Leisure Activities
* Male
* Middle Aged
* Mortality
* Neoplasms
* Proportional Hazards Models
* Prospective Studies
* Respiratory Tract Diseases
* Risk Factors
* Surveys and Questionnaires
* United States
|keywords=* Aging
* Cancer prevention study
* Leisure time physical activity
* Light-intensity physical activity
|full-text-url=https://sci-hub.do/10.1159/000502860
}}
==LPL==
 
{{medline-entry
|title=Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32684467
 
 
|keywords=* SNP effect
* Weibull hazards model
* genetic parameter
* health disorder
* longevity
|full-text-url=https://sci-hub.do/10.3168/jds.2020-18174
}}
{{medline-entry
|title=Influence of common health disorders on the length of productive life and stayability in German Holstein cows.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677834
 
|mesh-terms=* Animals
* Breeding
* Cattle
* Cattle Diseases
* Dairying
* Farmers
* Female
* Lactation
* Longevity
* Phenotype
|keywords=* genetic parameter
* health disorder
* longevity
* subjective culling reason
|full-text-url=https://sci-hub.do/10.3168/jds.2019-16985
}}
==LPO==
 
{{medline-entry
|title=[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160433
 
|mesh-terms=* Aging
* Animals
* Brain Ischemia
* Disease Models, Animal
* Lipid Peroxidation
* Rats
* Reperfusion Injury
* Sodium-Potassium-Exchanging ATPase
|keywords=* Na+/K+-ATPase
* aging
* brain
* lipid peroxidation
* oxidative stress
* stroke
 
}}
==LRP1==
 
{{medline-entry
|title=Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268785
 
|mesh-terms=* Animals
* Atherosclerosis
* Cellular Senescence
* Diet, Western
* Disease Models, Animal
* Indoleacetic Acids
* Macrophages
* Metabolic Syndrome
* Mice
* Mice, Knockout
* Obesity
* Plaque, Atherosclerotic
* Plasminogen Activator Inhibitor 1
* Receptors, LDL
|keywords=* atherosclerosis
* cellular senescence
* fibrinolysis
* metabolic syndrome
* muscle, smooth
* obesity
* plasminogen activator inhibitor-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255962
}}
==LRP4==
 
{{medline-entry
|title=Multiple MuSK signaling pathways and the aging neuromuscular junction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32353380
 
 
|keywords=* Aging
* BMP signaling
* MuSK
* Neuromuscular junction
* Synaptic maintenance
|full-text-url=https://sci-hub.do/10.1016/j.neulet.2020.135014
}}
==LRP6==
 
{{medline-entry
|title=Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32076828
 
|mesh-terms=* Aging
* Animals
* Cardiovascular Diseases
* Humans
* Low Density Lipoprotein Receptor-Related Protein-6
* Muscle, Smooth, Vascular
* Myocytes, Smooth Muscle
* Obesity
* Signal Transduction
* Structure-Activity Relationship
* Vascular Calcification
* Wnt Signaling Pathway
 
|full-text-url=https://sci-hub.do/10.1007/s00439-020-02124-8
}}
==LRRK2==
 
{{medline-entry
|title=Accelerated telomere shortening independent of [[LRRK2]] variants in Chinese patients with Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33122450
 
 
|keywords=* LRRK2 variants
* Parkinson’s disease
* aging
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655166
}}
{{medline-entry
|title=The effect of [[LRRK2]] loss-of-function variants in humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32461697
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Biological Specimen Banks
* Cell Line
* Embryonic Stem Cells
* Female
* Gain of Function Mutation
* Heterozygote
* Humans
* Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
* Longevity
* Loss of Function Mutation
* Lymphocytes
* Male
* Middle Aged
* Myocytes, Cardiac
* Parkinson Disease
* Phenotype
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303015
}}
{{medline-entry
|title=Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32075681
 
 
|keywords=* And aging
* Dendritic hypotrophy
* Excitability
* G2019S
* GABAA
* LRRK2
* Nuclear DNA damage
* Nuclear hypertrophy
* Nuclear invagination
* Parkinson’s disease
* R1441C
* Striatal spiny projection neuron
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031993
}}
{{medline-entry
|title=Autophagy and [[LRRK2]] in the Aging Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920513
 
 
|keywords=* LAMP2A
* LC3
* LRRK2
* Parkinson’s disease
* aging
* autophagy
* lysosomes
* α-synuclein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928047
}}
==LSS==
 
{{medline-entry
|title=Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32329390
 
 
|keywords=* aging
* elderly person
* gait speed
* lumbar spinal stenosis
* lumbar spine
* muscle strength
* sarcopenia
* skeletal muscle mass
* surgical result
|full-text-url=https://sci-hub.do/10.1177/2309499020918422
}}
{{medline-entry
|title=Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31867664
 
|mesh-terms=* Aged
* Aged, 80 and over
* Delivery of Health Care, Integrated
* Geriatrics
* Hip Fractures
* Hospitals, Teaching
* Humans
* Ireland
* Length of Stay
* Nerve Block
* Orthopedics
* Pain Management
* Total Quality Management
* Treatment Outcome
|keywords=* Lean Six Sigma
* healthcare outcomes
* hip fracture care
* integrated care pathways
* interdisciplinary working
* process improvement
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926383
}}
==LTA==
 
{{medline-entry
|title=Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814084
 
 
|keywords=* Aging
* Cell wall
* Cognition
* Goblet cell
* Inflammation
* Leaky gut
* Lipoteichoic acid
* Metabolism
* Mucin
* Physical function
* Probiotics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031475
}}
{{medline-entry
|title=The change of pain classes over time: a latent transition analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31680381
 
|mesh-terms=* Aged
* Aging
* Humans
* Life Style
* Longitudinal Studies
* Middle Aged
* Pain
* Quality of Life
 
|full-text-url=https://sci-hub.do/10.1002/ejp.1502
}}
==LY6D==
 
{{medline-entry
|title=[[LY6D]]-induced macropinocytosis as a survival mechanism of senescent cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168631
 
 
|keywords=* LY6D
* Ras protein
* cellular senescence
* endocytosis
* lipid raft
* macropinocytosis
* vacuole
|full-text-url=https://sci-hub.do/10.1074/jbc.RA120.013500
}}
==MAG==
 
{{medline-entry
|title=Exploration of life satisfaction of Korean people with sensory impairments across the lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327387
 
 
|keywords=* Across the lifespan
* Leisure domain
* Life satisfaction
* Sensory impairment
* Social domain
|full-text-url=https://sci-hub.do/10.1016/j.dhjo.2020.100931
}}
==MALT1==
 
{{medline-entry
|title=MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32350248
 
|mesh-terms=* Animals
* Behavior, Animal
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Gene Expression Regulation
* Green Fluorescent Proteins
* Immunity
* Interleukin-17
* Interneurons
* Longevity
* Models, Biological
* Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
* Neurons
* Oxygen
* Signal Transduction
* Subcellular Fractions
* Transgenes
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190641
}}
{{medline-entry
|title=[[MALT1]]-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31632405
 
|mesh-terms=* Age Factors
* Animals
* CTLA-4 Antigen
* Cytokines
* Dermatitis, Atopic
* Disease Models, Animal
* Disease Susceptibility
* Gene Expression
* Genetic Predisposition to Disease
* Immunoglobulin E
* Lymphocyte Activation
* Mice
* Mice, Knockout
* Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
* Skin
* T-Lymphocyte Subsets
|keywords=* MALT1
* Th2
* Tregs
* aging
* atopic dermatitis
* lymphocytes
* skin inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779721
}}
==MAP2==
 
{{medline-entry
|title=Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314365
 
 
|keywords=* aging
* diffusion tensor imaging
* immunohistochemistry
* ischemic preconditioning
|full-text-url=https://sci-hub.do/10.1111/jnc.15029
}}
==MAP4K3==
 
{{medline-entry
|title=[[MAP4K3]]/GLK in autoimmune disease, cancer and aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31640697
 
|mesh-terms=* Aging
* Autoimmune Diseases
* Humans
* Neoplasms
* Protein-Serine-Threonine Kinases
|keywords=* Aging
* Autoimmune disease
* Autophagy
* Cancer metastasis
* HPK1
* IL-17A
* IQGAP1
* MAP4K3 (GLK)
* PKCθ
* Verteporfin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806545
}}
==MAPK1==
 
{{medline-entry
|title=Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850814
 
 
|keywords=* MAPK1
* VB1
* purified vitexin compound 1
* senescence
* skin photoaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413062
}}
==MAPKAPK2==
 
{{medline-entry
|title=Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801093
 
|mesh-terms=* AMP-Activated Protein Kinases
* Animals
* Calcium
* Cell Line
* Endocytosis
* HEK293 Cells
* Homeostasis
* Humans
* Intracellular Signaling Peptides and Proteins
* Liver
* Metformin
* Mice
* Phosphorylation
* Protein Kinase C
* Protein-Serine-Threonine Kinases
* Proteomics
* Signal Transduction
|keywords=* AMPK3
* LKB1
* PKD1
* STIM1
* aging
* calcium
* diabetes
* kinases
* liver
* metformin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980792
}}
==MAPT==
 
{{medline-entry
|title=Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001736
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alcohol Drinking
* Biological Specimen Banks
* Brain
* Cognition
* Female
* Humans
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Neuroimaging
* Polymorphism, Single Nucleotide
* Smoking
* United Kingdom
* tau Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992742
}}
{{medline-entry
|title=A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31921969
 
 
|keywords=* Aging
* Biomarkers of diet quality
* Cognitive decline
* DHA
* EPA
* Elderly
* Homocysteine
* Metabolomics
* Nutrient biomarkers
* Omega-3 fatty acids
* Vitamin D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944714
}}
{{medline-entry
|title=Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The [[MAPT]] study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669813
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Body Composition
* Brain
* Cognition
* Exercise
* Female
* Humans
* Longitudinal Studies
* Male
|keywords=* Aging
* Biomarkers
* Phenotype
* Physical activity
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110758
}}
{{medline-entry
|title=Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31673052
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Amyloidosis
* Animals
* Disease Models, Animal
* Mice
* Mice, Transgenic
* tau Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823454
}}
{{medline-entry
|title=Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31604111
 
 
|keywords=* Alzheimer’s disease
* Ferroptosis
* Iron
* Reactive oxygen species
* Senescence
* Tau
|full-text-url=https://sci-hub.do/10.1016/j.pneurobio.2019.101716
}}
==MATN3==
 
{{medline-entry
|title=Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31963938
 
|mesh-terms=* Aging
* Animals
* Cell Proliferation
* Cells, Cultured
* Chondrocytes
* Disease Models, Animal
* Female
* Gene Knockout Techniques
* Humans
* Male
* Matrilin Proteins
* Mice
* Mice, Knockout
* Microscopy, Atomic Force
* Muscle, Skeletal
* Osteoarthritis
|keywords=* articular cartilage
* bone development
* cartilage
* matrilin
* osteoarthritis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013758
}}
==MB==
 
{{medline-entry
|title=Probing menstrual bloodstain aging with fluorescence spectroscopy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279406
 
 
|keywords=* Aging
* Analytical methods
* Blood
* Fluorescence spectroscopy
* Forensics
|full-text-url=https://sci-hub.do/10.1016/j.saa.2020.119172
}}
{{medline-entry
|title=Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32989840
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cognition
* Cross-Sectional Studies
* Exercise
* Exercise Therapy
* Female
* Humans
* Male
* Middle Aged
* Risk Factors
* Vascular Diseases
|keywords=* active aging
* cognitive preservation
* exercise habit
* lifestyle advice
* vascular care
|full-text-url=https://sci-hub.do/10.1111/ggi.14048
}}
{{medline-entry
|title=A novel indenone derivative selectively induces senescence in MDA-[[MB]]-231 (breast adenocarcinoma) cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32956706
 
|mesh-terms=* Antineoplastic Agents
* Breast Neoplasms
* Catalysis
* Cell Line, Tumor
* Cell Survival
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Down-Regulation
* Female
* G1 Phase Cell Cycle Checkpoints
* Humans
* Palladium
* Sulfonamides
* Survivin
* Tumor Suppressor Protein p53
* Up-Regulation
|keywords=* Cell cycle arrest
* Novel indenone derivative
* Senescence
* Triple-negative breast cancer
|full-text-url=https://sci-hub.do/10.1016/j.cbi.2020.109250
}}
{{medline-entry
|title=Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846959
 
 
|keywords=* DNA damage
* Rubicon
* SQSTM1/p62
* TFEB
* autophagic index
* autophagy
* cancer
* polyploidy
* senescence
* senescence escape
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504443
}}
{{medline-entry
|title=Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32627932
 
 
|keywords=* Drosophila
* Rab27
* S6K
* TOR
* lifespan extension
* mushroom body
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431830
}}
{{medline-entry
|title=Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32485849
 
 
|keywords=* apoptosis
* cancer stem-like cells
* doxorubicin
* magnetic iron oxide nanoparticles
* mitotic catastrophe
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352336
}}
{{medline-entry
|title="Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32316332
 
 
|keywords=* ALT
* SQSTM1/p62
* amoeboid conversion
* budding of mitotic progeny
* cellular senescence
* extranuclear DNA
* genotoxic treatment
* inverted meiosis
* mtTP53 cancer
* polyploidization
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215480
}}
{{medline-entry
|title=Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771226
 
|mesh-terms=* Antineoplastic Agents
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Doxorubicin
* Fluorouracil
* Humans
* Irinotecan
* Methotrexate
* Neoplasms
* Oxaliplatin
* Paclitaxel
* Phenotype
* Tumor Cells, Cultured
|keywords=* DNA damage
* SASP
* cancer
* chemotherapy
* senescence
* senescence markers
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952928
}}
{{medline-entry
|title=Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31605433
 
 
|keywords=*
Spalax
 
* DNA damage
* DNA repair
* cellular senescence
* interleukin-1 alpha (IL1α)
* nuclear factor κB (NF-κB)
* senescence-associated secretory phenotype (SASP)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974727
}}
{{medline-entry
|title=Quantification of the health-status of the Dutch Labrador retriever population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494529
 
|mesh-terms=* Animals
* Dog Diseases
* Dogs
* Female
* Health Status
* Insurance
* Laboratories
* Longevity
* Male
* Netherlands
* Proportional Hazards Models
* Risk Factors
|keywords=* Canine health
* Data analysis
* Health parameters
* Labrador retriever
* Lifespan
* Oncology
|full-text-url=https://sci-hub.do/10.1016/j.prevetmed.2019.104764
}}
{{medline-entry
|title=Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441212
 
|mesh-terms=* ATP-Binding Cassette Transporters
* Breast Neoplasms
* Cell Cycle Checkpoints
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Cyclin-Dependent Kinase Inhibitor p21
* Female
* Glucuronides
* Humans
* MCF-7 Cells
* Resveratrol
* Retinoblastoma Protein
* Signal Transduction
* Stilbenes
* Tumor Suppressor Protein p53
|keywords=* ABC transporters
* breast cancer
* deconjugation
* resveratrol metabolites
* senescence
|full-text-url=https://sci-hub.do/10.1002/mnfr.201900629
}}
==MBP==
 
{{medline-entry
|title=Demyelination associated with chronic arsenic exposure in Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171569
 
|mesh-terms=* Aging
* Amyloid beta-Protein Precursor
* Animals
* Arsenic Poisoning
* Arsenites
* Axons
* Corpus Callosum
* Demyelinating Diseases
* Diffusion Tensor Imaging
* Drinking Water
* Immunohistochemistry
* Male
* Mitochondria
* Myelin Basic Protein
* Neurofilament Proteins
* Prefrontal Cortex
* Rats
* Rats, Wistar
* Sodium Compounds
* White Matter
|keywords=* Amyloid
* Anisotropy
* Arsenic
* Axonal damage
* DTI
* Demyelination
* Development
* MRI
* Microstructure
* Mitochondria
|full-text-url=https://sci-hub.do/10.1016/j.taap.2020.114955
}}
{{medline-entry
|title=Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32140045
 
 
|keywords=* EAE
* NK cells
* aging
* dendritic cells
* strain differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050050
}}
==MCC==
 
{{medline-entry
|title=Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32633198
 
 
|keywords=* Aging
* and memory study
* cognitive impairment with no dementia
* dementia
* demographics
* multimorbidity
* multiple chronic conditions
|full-text-url=https://sci-hub.do/10.1080/13825585.2020.1790492
}}
{{medline-entry
|title=Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32348871
 
 
|keywords=* Aging
* Behaviour consistency
* Heart rate
* Physical activity
* Treadmill running
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2020.112619
}}
{{medline-entry
|title=Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31475644
 
 
|keywords=* aging
* analyse d’intersectionnalité
* caregiver burden
* fardeau de l’aidant
* gender
* interférence sociale
* intersectionality analysis
* maladies chroniques multiples
* multiple chronic conditions
* sexe
* social interference
* vieillissement
|full-text-url=https://sci-hub.do/10.1017/S071498081900045X
}}
==MCM9==
 
{{medline-entry
|title=MCM8- and [[MCM9]] Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31509747
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Bone Marrow
* Cell Differentiation
* Cell Proliferation
* DNA Damage
* Gene Expression Regulation, Leukemic
* Hematologic Neoplasms
* Mice
* Mice, Knockout
* Minichromosome Maintenance Proteins
* Retinoblastoma Protein
* Signal Transduction
* Splenomegaly
* Tumor Suppressor Protein p53
|keywords=* DNA damage
* DNA repair
* MCM8
* MCM9
* cancer
* hematopoiesis
* homologous recombination
* myelodysplastic syndrome
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.07.095
}}
==MCU==
 
{{medline-entry
|title=A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931725
 
|mesh-terms=* Aged, 80 and over
* Colon, Transverse
* Epstein-Barr Virus Infections
* Herpesvirus 4, Human
* Humans
* Intestinal Mucosa
* Intestinal Obstruction
* Male
* Ulcer
|keywords=* Aging
* Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU)
* Immunosuppression
* Intestinal obstruction
* Surgical resection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958744
}}
{{medline-entry
|title=Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712319
 
|mesh-terms=* Adipocytes, Brown
* Adipose Tissue, Brown
* Aging
* Animals
* Calcium
* Capsaicin
* Gene Expression Regulation
* Mice
* Mice, Knockout
* Mitochondria
* Obesity
* Sirtuin 3
 
|full-text-url=https://sci-hub.do/10.2337/db19-0526
}}
==MDH1==
 
{{medline-entry
|title=Oxidative Damage to the TCA Cycle Enzyme [[MDH1]] Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32175745
 
 
|keywords=* DPM
* MRM
* TCA cycle
* aging
* brain
|full-text-url=https://sci-hub.do/10.1021/acs.jproteome.9b00861
}}
==MDM2==
 
{{medline-entry
|title=SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030426
 
|mesh-terms=* Aging
* Animals
* Carcinogenesis
* Cyclin-Dependent Kinase Inhibitor p21
* Gene Expression Regulation, Neoplastic
* HCT116 Cells
* Heterografts
* Histone Deacetylases
* Humans
* Mice
* Neoplasms
* Protein Binding
* RNA, Long Noncoding
* Signal Transduction
* Tumor Suppressor Protein p53
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102969
}}
{{medline-entry
|title=Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31534052
 
|mesh-terms=* Animals
* Cell Differentiation
* Cell Proliferation
* Cellular Senescence
* Cilia
* Disease Models, Animal
* Epithelial Cells
* Humans
* Kidney
* Kidney Diseases, Cystic
* Mice
* Mice, Knockout
* Nerve Tissue Proteins
* Protein Binding
* Protein Domains
* Receptors, Immunologic
* Signal Transduction
* Tumor Suppressor Protein p53
|keywords=* Cellular senescence
* Development
* Genetic diseases
* Nephrology
* Signal transduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795383
}}
{{medline-entry
|title=Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31478614
 
|mesh-terms=* Amniocentesis
* Amnion
* Biomarkers
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Electrophysiological Phenomena
* Female
* Gene Expression Regulation
* Humans
* Immunophenotyping
* Phenotype
|keywords=* amniocyte
* automated patch-clamp
* flow cytometry
* mesenchymal stem cell
* qRT-PCR
* replicative senescence
* senescence-associated secretory phenotype
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815807
}}
==MED25==
 
{{medline-entry
|title=The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468026
 
 
|keywords=* ERF022
* H3K9ac
* HAC1
* Mediator complex
* histone acetylation
* leaf senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710649
}}
==MEFV==
 
{{medline-entry
|title=The grandfather's fever.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31401792
 
|mesh-terms=* Age of Onset
* Aged, 80 and over
* Familial Mediterranean Fever
* Female
* Humans
* Male
* Pedigree
* Pyrin
|keywords=* Autoinflammatory diseases
* FMF
* Genetics
* Geriatrics
* Periodic fever
|full-text-url=https://sci-hub.do/10.1007/s10067-019-04741-9
}}
==MEOX2==
 
{{medline-entry
|title=Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32457253
 
 
|keywords=* aging
* angiogenesis
* microRNA
* neovascularization
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346016
}}
==MET==
 
{{medline-entry
|title=Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979089
 
 
|keywords=* Cancer survivorship
* Epidemiology
* Fruit and vegetable
* Gerontology
* Physical activity
|full-text-url=https://sci-hub.do/10.1007/s00520-020-05782-6
}}
{{medline-entry
|title=Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32170049
 
 
|keywords=* exercise
* healthy aging
* physical activity
* retirement
* successful aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185
}}
{{medline-entry
|title=Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815663
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Heterochromatin
* Histone-Lysine N-Methyltransferase
* Histones
* Inheritance Patterns
* Jumonji Domain-Containing Histone Demethylases
* Longevity
* Lysine
* Methylation
* Mutation
|keywords=* C. elegans
* COMPASS
* aging
* chromatin
* chromosomes
* epigenetics
* gene expression
* genetics
* genomics
* heterochromatin
* transgenerational inheritance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299346
}}
{{medline-entry
|title=Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518246
 
 
|keywords=* aging
* cadence
* physical activity intensity
* public health
* walking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715008
}}
==MFI==
 
{{medline-entry
|title=The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32825284
 
 
|keywords=* HDPE
* accelerated aging tests
* decrease mechanical properties
* degradation
* geosynthetics
* landfill
* polyolefin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564637
}}
{{medline-entry
|title=Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32575353
 
 
|keywords=* aging
* beef muscle
* microstructure
* myofibril fragmentation
* protein solubility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353465
}}
{{medline-entry
|title=Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583539
 
|mesh-terms=* Animals
* Cattle
* Cold Temperature
* Electric Stimulation
* Food Handling
* Food Quality
* Food Storage
* Hydrogen-Ion Concentration
* Male
* Meat
* Muscle, Skeletal
* Polysaccharides
* Postmortem Changes
* Time Factors
|keywords=* Yak
* electrical stimulation
* postmortem aging
* tenderness
|full-text-url=https://sci-hub.do/10.1111/asj.13410
}}
{{medline-entry
|title=Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480178
 
 
|keywords=* Beef Loin
* Digestibility
* Dry Aging
* Shear Force
* Wet Aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054618
}}
==MFN2==
 
{{medline-entry
|title=Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049718
 
 
|keywords=* aging
* heart
* ischemia-reperfusion
* mitochondria
* thioredoxin
|full-text-url=https://sci-hub.do/10.18632/aging.104071
}}
{{medline-entry
|title=[[MFN2]] contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416221
 
 
|keywords=* Aging
* Inflammation
* MFN2
* Metabolic disorders
* Osteoarthritis
|full-text-url=https://sci-hub.do/10.1016/j.joca.2019.11.011
}}
==MFSD2A==
 
{{medline-entry
|title=Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31861865
 
|mesh-terms=* Aged
* Alzheimer Disease
* Biomarkers
* Brain
* Fatty Acids
* Female
* Humans
* Male
* Symporters
|keywords=* Alzheimer’s disease
* MFSD2a carrier
* aging
* neurologic disorders
* omega-3 PUFA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981746
}}
==MGMT==
 
{{medline-entry
|title=Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32977591
 
 
|keywords=* apoptosis
* cancer therapy
* drug resistance
* glioblastoma
* methadone
* senescence
* temozolomide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582495
}}
==MIA==
 
{{medline-entry
|title=Age, cohort, and period effects on metamemory beliefs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31804113
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Cross-Sectional Studies
* Female
* Humans
* Longitudinal Studies
* Male
* Metacognition
* Middle Aged
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901096
}}
{{medline-entry
|title=Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752597
 
|mesh-terms=* Aged
* Aging
* Anxiety
* Female
* Humans
* Internal-External Control
* Male
* Memory, Episodic
* Metacognition
* Middle Aged
* Stereotyping
 
|full-text-url=https://sci-hub.do/10.1080/0361073X.2019.1693009
}}
==MIB1==
 
{{medline-entry
|title=Immunohistochemical detection of senescence markers in human sarcomas.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31899047
 
 
|keywords=* SenTraGor
* Senescence
* p16
* p21
* sarcoma
|full-text-url=https://sci-hub.do/10.1016/j.prp.2019.152800
}}
==MIP==
 
{{medline-entry
|title=Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32705393
 
 
|keywords=* Aging
* Cardiac output
* Center-of-pressure
* Middle cerebral artery blood flow velocity
* Respiratory muscles
|full-text-url=https://sci-hub.do/10.1007/s00421-020-04441-2
}}
{{medline-entry
|title=A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32458283
 
 
|keywords=* Aging
* Amino acids
* Cytokines
* Metabolomics
* Neurodegeneration
* Personalized medicine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525911
}}
{{medline-entry
|title=Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32387511
 
 
|keywords=* Brain aging
* Chemokines
* Cognitive aging
* Exercise
* Gender
* Inflammation
* Lifestyle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416443
}}
{{medline-entry
|title=Comparison of balance changes after inspiratory muscle or Otago exercise training.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978126
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Breathing Exercises
* Exercise
* Exercise Therapy
* Female
* Humans
* Male
* Maximal Respiratory Pressures
* Muscle Strength
* Physical Endurance
* Postural Balance
* Respiratory Muscles
* Respiratory Therapy
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980667
}}
==MITF==
 
{{medline-entry
|title=Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707654
 
 
|keywords=* Nigella sativa
* Thymocid®
* black cumin
* collagen
* collagenase
* cosmeceutical
* elastase
* glycation
* melanogenesis
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400895
}}
{{medline-entry
|title=HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455577
 
 
|keywords=* HuR
* MITF
* Microphthalmia-associated transcription factor
* malignant melanoma
* oncogene induced senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281285
}}
==MLH1==
 
{{medline-entry
|title=The somatic mutation landscape of the human body.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31874648
 
|mesh-terms=* Age Factors
* Aging
* Humans
* Mutation
* Neoplasms
* Selection, Genetic
* Sex Factors
|keywords=* Aging
* Cancer
* Genomic instability
* Human
* Somatic evolution
* Somatic mutation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930685
}}
==MLKL==
 
{{medline-entry
|title=Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32584786
 
 
|keywords=* cardiomyocytes
* hypoxia
* necroptosis
* remifentanil
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425462
}}
==MLN==
 
{{medline-entry
|title=Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849526
 
 
|keywords=* RALDH2
* aging
* dendritic cells
* epigenetic regulation
* regulatory T cells
* retinoic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432217
}}
==MMD==
 
{{medline-entry
|title=Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266358
 
 
|keywords=* LIFE Study
* deficit accumulation
* disability
* frailty
* healthy aging
* mobility
* older adults
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700674
}}
{{medline-entry
|title=Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32947839
 
 
|keywords=* anticholinergic burden
* falls
* mobility
* physical activity
* successful aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564216
}}
{{medline-entry
|title=Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105353
 
 
|keywords=* aging
* mobility disability
* multicenter trialphysical activity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187344
}}
==MME==
 
{{medline-entry
|title=Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32284953
 
 
|keywords=* aging
* older adults
* opioid harm reduction
* overdose risk
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139179
}}
{{medline-entry
|title=Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31564373
 
|mesh-terms=* Aged
* Aged, 80 and over
* Analgesics, Opioid
* Anesthetics, Local
* Delirium
* Female
* Femoral Fractures
* Fracture Fixation, Internal
* Geriatrics
* Humans
* Injections, Intra-Articular
* Intraoperative Care
* Male
* Pain Management
* Pain, Postoperative
* Retrospective Studies
|keywords=* Geriatrics
* Hip fracture
* Local anesthetic
* Narcotics
|full-text-url=https://sci-hub.do/10.1016/j.injury.2019.09.013
}}
==MMP1==
 
{{medline-entry
|title=Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32533368
 
 
|keywords=* Cell shape
* Fibroblast
* Lithography
* SASP
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09886-8
}}
{{medline-entry
|title=A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31584241
 
 
|keywords=* anti-wrinkle
* pigmentation
* pollution
* skin aging
* skin barrier
|full-text-url=https://sci-hub.do/10.1111/jocd.13176
}}
==MMP13==
 
{{medline-entry
|title=Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31909538
 
|mesh-terms=* Aging
* Animals
* Antigens, Differentiation
* Chondrocytes
* Chondrogenesis
* Core Binding Factor Alpha 1 Subunit
* Fetal Proteins
* Gene Expression Regulation
* Intervertebral Disc Degeneration
* Mice
* Mice, Transgenic
* Sp7 Transcription Factor
* T-Box Domain Proteins
|keywords=* Wnt/β-catenin/LRPs
* biomechanics
* genetic animal models
* osterix
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018543
}}
==MOS==
 
{{medline-entry
|title=Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066764
 
|mesh-terms=* Actinobacteria
* Aeromonas
* Animal Feed
* Animals
* Aquaculture
* Bacterial Adhesion
* Ecuador
* Flavobacteriaceae
* Lactococcus
* Longevity
* Mannans
* Microbiota
* Oligosaccharides
* Penaeidae
* Proteobacteria
* Seafood
* Shewanella
* Verrucomicrobia
* Vibrio
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026423
}}
{{medline-entry
|title=Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31870166
 
 
|keywords=* Chiang Mai
* HIV and aging
* Older adults living with HIV
* Thailand
* health-related quality of life
* quality of life
|full-text-url=https://sci-hub.do/10.1080/09540121.2019.1707472
}}
{{medline-entry
|title=Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31766992
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aged, 80 and over
* Aging
* China
* Cross-Sectional Studies
* Ethnic Groups
* Female
* Humans
* Male
* Middle Aged
* Quality of Life
|keywords=* ADL
* Elderly
* Health-related quality of life
* IADL
* Yi ethnic minority
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878633
}}
{{medline-entry
|title=Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561025
 
|mesh-terms=* Animal Feed
* Animals
* Antioxidants
* Diet
* Dietary Supplements
* Dose-Response Relationship, Drug
* Gastropoda
* Immunity, Innate
* Longevity
* Mannans
* Oligosaccharides
* Vibrio parahaemolyticus
|keywords=* Abalone
* Antioxidation
* Bacterial challenge
* Disease resistance
* Growth
* Immunity
* Mannan oligosaccharide
|full-text-url=https://sci-hub.do/10.1016/j.fsi.2019.09.058
}}
==MPHOSPH6==
 
{{medline-entry
|title=Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109421
 
|mesh-terms=* Genome-Wide Association Study
* Humans
* Leukocytes
* Nucleotides
* Telomere
|keywords=* Mendelian randomisation
* age-related disease
* biological aging
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058826
}}
==MPI==
 
{{medline-entry
|title=Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32251650
 
 
|keywords=* Age-related
* Aging
* Aqueous humor
* Drainage
* Eye
* Glaucoma
* Imaging
* In vivo
* Lymph node
* Lymphatic
* Mice
* Photoacoustic tomography
* Uveoscleral
|full-text-url=https://sci-hub.do/10.1016/j.exer.2020.108029
}}
{{medline-entry
|title=Interest of the multidimensional prognostic index ([[MPI]]) as an assessment tool in hospitalized patients in geriatrics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570330
 
|mesh-terms=* Aged, 80 and over
* Female
* Geriatric Assessment
* Hospital Mortality
* Hospitalization
* Humans
* Length of Stay
* Male
* Patient Readmission
* Prognosis
|keywords=* elderly
* geriatrics
* hospitalization
* multidimensional prognostic index
|full-text-url=https://sci-hub.do/10.1684/pnv.2019.0823
}}
==MRE11==
 
{{medline-entry
|title=Chromosomal alterations among age-related haematopoietic clones in Japan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581364
 
|mesh-terms=* Aged, 80 and over
* Aging
* Alleles
* Cell Lineage
* Chromosome Aberrations
* Chromosomes, Human
* Clone Cells
* Cohort Studies
* Female
* Genetic Loci
* Genome, Human
* Hematopoiesis
* Hematopoietic Stem Cells
* Humans
* Japan
* Leukemia, Lymphocytic, Chronic, B-Cell
* Leukemia, T-Cell
* Male
* Mosaicism
* Mutation
* United Kingdom
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489641
}}
==MSC==
 
{{medline-entry
|title=Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33294742
 
 
|keywords=* BM, bone marrow
* CVD, cardiovascular disease
* EC, endothelial cell
* EPC, endothelial progenitor cell
* EV, extracellular vesicle
* FBS, fetal bovine serum
* MEM, minimum essential medium
* MI, myocardial infarction
* MSC, mesenchymal stromal cell
* NTA, nanotracking analysis
* PBS, phosphate-buffered saline
* TEV, tailored extracellular vesicle
* VEGF, vascular endothelial growth factor
* acellular
* angiogenesis
* extracellular vesicles
* lin− BMC, lineage negative bone marrow cell
* miR, microRNA
* qPCR, quantitative transcription polymerase chain reaction
* regeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691285
}}
{{medline-entry
|title=Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264634
 
 
|keywords=* Aging
* Cortical injury
* Extracellular vesicles
* Monkeys
* Myelin
* Non-human primates
* Oligodendrocytes
* Stroke
* White matter
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113540
}}
{{medline-entry
|title=TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33195247
 
 
|keywords=* DNA repair
* aging
* myocardial infarction
* stem cells therapy
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658181
}}
{{medline-entry
|title=Aging-Affected [[MSC]] Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143068
 
 
|keywords=* aging
* bone resorption
* immunomodulation
* mesenchymal stem cell
* periodontitis
* tissue destruction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663404
}}
{{medline-entry
|title=Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153492
 
 
|keywords=* Aging
* Follicular development
* Hormone biosynthesis
* Primordial follicle activation
* Stem cell therapy
* miR-145
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643421
}}
{{medline-entry
|title=Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102483
 
 
|keywords=* adult stem cells
* aging
* mesenchymal stromal cells (MSC)
* regenerative medicine
* stem cell niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546871
}}
{{medline-entry
|title=The biology of human hair greying.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965076
 
 
|keywords=* ageing
* endocrine
* graying
* melanin
* senescence
|full-text-url=https://sci-hub.do/10.1111/brv.12648
}}
{{medline-entry
|title=[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927859
 
 
|keywords=* TSC1
* mammalian target of rapamycin (mTOR)
* mesenchymal stem cell
* senescence
* stem cell proliferation
* tuberous sclerosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565438
}}
{{medline-entry
|title=The role of mitochondrial dysfunction in mesenchymal stem cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32803322
 
 
|keywords=* Mesenchymal stem cells
* Mitochondrial dysfunction
* Mitophagy
* Reactive oxygen species
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s00441-020-03272-z
}}
{{medline-entry
|title=Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787856
 
 
|keywords=* EV
* MSC
* Metabolic syndrome
* RNA-sequencing
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425605
}}
{{medline-entry
|title=Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32699947
 
 
|keywords=* Aging diseases
* Conditioned medium
* Diabetes
* Exosomes
* Extracellular vesicles
* Lupus
* Regenerative medicine
* Secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375036
}}
{{medline-entry
|title=Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of [[MSC]]s.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660632
 
 
|keywords=* Aging
* Heterochromatin
* MSC senescence
* mTORC1/p70S6K
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359252
}}
{{medline-entry
|title=Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32657444
 
 
|keywords=* cellular senescence
* exosomes
* kidney
* mesenchymal stem cells
* renal artery obstruction
|full-text-url=https://sci-hub.do/10.1002/jcp.29940
}}
{{medline-entry
|title=Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271  Multipotential Stromal Cells (BM-[[MSC]]s): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679782
 
 
|keywords=* aging
* bone marrow
* mesenchymal stromal cells
* senescence
* type 1 interferon
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399891
}}
{{medline-entry
|title=Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32623814
 
 
|keywords=* amniotic fluid stem cells products
* dermaroller
* facial aging
* skin needling
|full-text-url=https://sci-hub.do/10.1111/jocd.13594
}}
{{medline-entry
|title=Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582691
 
 
|keywords=* autophagy
* mesenchymal stem cells
* mitochondrial
* rejuvenation
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283395
}}
{{medline-entry
|title=The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32445894
 
 
|keywords=* Aging
* DNA methylation
* Epigenetics
* Histome modifications
* MSC
* Mesenchymal Stem/Stromal Cells
* Skeleton
* miRNA
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115440
}}
{{medline-entry
|title=Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32391362
 
 
|keywords=* SASP
* general autophagy
* mesenchymal stem cell
* selective autophagy
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193103
}}
{{medline-entry
|title=Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314614
 
 
|keywords=* adipose-derived stromal/stem cell
* aging
* gene expression
* long-term culture
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586277
}}
{{medline-entry
|title=Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32274385
 
 
|keywords=* adipose tissue
* cellular dysfunction
* cellular senescence
* mesenchymal stem cells
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113401
}}
{{medline-entry
|title=miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196916
 
 
|keywords=* mesenchymal stem cells
* miR-155-5p
* myocardial infarction
* rejuvenation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189985
}}
{{medline-entry
|title=Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154253
 
 
|keywords=* aging
* clinical translation
* extracellular vesicles
* mesenchymal stem cells
* regenerative medicine
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047768
}}
{{medline-entry
|title=Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098040
 
 
|keywords=* MSC senescence
* in vitro aging
* in vivo aging
* mesenchymal stem/stromal cells (MSC)
* rejuvenating strategies
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072652
}}
{{medline-entry
|title=Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125888
 
 
|keywords=* RG108
* apoptosis
* pluripotency
* porcine bone marrow mesenchymal stem cells
* senescence
|full-text-url=https://sci-hub.do/10.1089/cell.2019.0060
}}
{{medline-entry
|title=Extracellular Vesicles of Stem Cells to Prevent BRONJ.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119600
 
 
|keywords=* bisphosphonate-associated osteonecrosis of the jaw
* cellular senescence
* exosomes
* mesenchymal stem cells
* wound healing
* zoledronic acid
|full-text-url=https://sci-hub.do/10.1177/0022034520906793
}}
{{medline-entry
|title=Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038244
 
 
|keywords=* apoptosis
* differentiation
* ginsenoside Rg1
* mesenchymal stem cells
* preclinical study
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989539
}}
{{medline-entry
|title=The Importance of Stem Cell Senescence in Regenerative Medicine.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026416
 
 
|keywords=* Aging
* Mesenchymal stem cell
* Regenerative medicine
|full-text-url=https://sci-hub.do/10.1007/5584_2020_489
}}
{{medline-entry
|title=Control of mesenchymal stem cell biology by histone modifications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025282
 
 
|keywords=* Cell biology
* Cell differentiation
* Cellular senescence
* Epigenetics
* Histone modifications
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996187
}}
{{medline-entry
|title=Impact of mesenchymal stem cell senescence on inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964472
 
|mesh-terms=* Aging
* Cellular Senescence
* Cytokines
* Hematopoiesis
* Humans
* Immunomodulation
* Immunosenescence
* Inflammation
* Macrophages
* Mesenchymal Stem Cells
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061209
}}
{{medline-entry
|title=Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31918630
 
 
|keywords=* COPD
* aging
* lung
* newborn
* regenerative medicine
* stem cells
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0116
}}
{{medline-entry
|title=Low-Level Radiofrequency Exposure Does Not Induce Changes in [[MSC]] Biology: An in vitro Study for the Prevention of NIR-Related Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31908499
 
 
|keywords=* 169 MHz
* CFU
* senescence
* stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927227
}}
{{medline-entry
|title=Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881006
 
|mesh-terms=* Adolescent
* Aged
* Aged, 80 and over
* Aging
* Animals
* Animals, Newborn
* Cellular Senescence
* Humans
* Macrophage Migration-Inhibitory Factors
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Myocardial Infarction
* Myocardium
* Myocytes, Cardiac
* Rats
* Rats, Sprague-Dawley
* Young Adult
|keywords=* macrophage migration inhibitory factor
* mesenchymal stem cells
* myocardial infarction
* rejuvenation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949107
}}
{{medline-entry
|title=Influence of olive oil and its components on mesenchymal stem cell biology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31875868
 
 
|keywords=* Aging
* Cellular differentiation
* Cellular niche
* Mediterranean diet
* Mesenchymal stem cells
* Olive oil
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904865
}}
{{medline-entry
|title=Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866188
 
 
|keywords=* aging
* epigenetics
* fate decision
* mesenchymal stem cells
* pathogenesis
* regeneration
|full-text-url=https://sci-hub.do/10.1016/j.tcb.2019.11.006
}}
{{medline-entry
|title=Mesenchymal Stem Cells: Allogeneic [[MSC]] May Be Immunosuppressive but Autologous [[MSC]] Are Dysfunctional in Lupus Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31799252
 
 
|keywords=* dysfunction
* immunoregulatory
* mesenchymal stem cells
* senescence
* systemic lupus erythematosus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874144
}}
{{medline-entry
|title=Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752674
 
|mesh-terms=* Adipogenesis
* Animals
* Biomarkers
* Bone Regeneration
* Bone and Bones
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Diabetes Mellitus, Type 2
* Glucose
* Hyperglycemia
* Male
* Mesenchymal Stem Cells
* Osteogenesis
* Rats, Wistar
|keywords=* Bone repair
* Cellular senescence
* Differentiation
* Hyperglycaemia
* Mesenchymal stromal cells; Endosteum
* Type II diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873668
}}
{{medline-entry
|title=Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31675454
 
 
|keywords=* ROS/JNK/p38 signalling
* autophagy
* mesenchymal stem cells
* senescence
|full-text-url=https://sci-hub.do/10.1111/1440-1681.13207
}}
{{medline-entry
|title=Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692976
 
 
|keywords=* Anoikis
* Bioactive scaffolds
* Bone regeneration
* Engraftment
* Homing
* Hypoxia
* Mesenchymal stem cells
* Osteogenesis
* Preconditioning
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828596
}}
{{medline-entry
|title=Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644429
 
|mesh-terms=* Animals
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Chondrocytes
* Coculture Techniques
* Collagenases
* Etoposide
* Gene Expression Regulation
* Humans
* Inflammation
* Luciferases
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred Strains
* Mice, Transgenic
* Osteoarthritis
* Paracrine Communication
|keywords=* mesenchymal stem cell
* osteoarthritis
* senescence
* tissue homeostasis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834426
}}
{{medline-entry
|title=Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660081
 
|mesh-terms=* Animals
* Cell- and Tissue-Based Therapy
* Cellular Senescence
* Disease Models, Animal
* Embryonic Stem Cells
* Extracellular Vesicles
* Humans
* Insulin-Like Growth Factor I
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred BALB C
* Phosphatidylinositol 3-Kinases
* Wounds and Injuries
|keywords=* Cellular senescence
* Embryonic stem cells
* Extracellular vesicles
* IGF1/PI3K/AKT pathway
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815953
}}
{{medline-entry
|title=Survival of aging CD264  and CD264  populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612990
 
 
|keywords=* aging
* decoy TRAIL receptor 2 (CD264)
* mesenchymal stem cells
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906265
}}
{{medline-entry
|title=Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575829
 
|mesh-terms=* Acute Lung Injury
* Age Factors
* Animals
* Disease Models, Animal
* Extracellular Vesicles
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Treatment Outcome
|keywords=* ARDS
* acute lung injury
* aging
* extracellular vesicles
* mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781978
}}
{{medline-entry
|title=Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514306
 
|mesh-terms=* Adipogenesis
* Cell Differentiation
* Cellular Senescence
* Connexin 43
* Gene Expression Regulation
* Humans
* Mesenchymal Stem Cells
* Time Factors
|keywords=* CRISPR-Cas9
* adipogenesis
* connexin43
* gap junctional intercellular communication
* mesenchymal stem cells
* oculodentodigital dysplasia
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770901
}}
{{medline-entry
|title=Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440385
 
 
|keywords=* inflammation
* mesenchymal stem cells
* periodontitis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675537
}}
==MTHFR==
 
{{medline-entry
|title=One-carbon metabolism supplementation improves outcome after stroke in aged male [[MTHFR]]-deficient mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31525435
 
|mesh-terms=* Aging
* Animals
* Brain
* Choline
* Dietary Supplements
* Male
* Methylenetetrahydrofolate Reductase (NADPH2)
* Mice
* Mice, Inbred C57BL
* Recovery of Function
* Stroke
* Tetrahydrofolates
* Vitamin B 12
|keywords=* Cerebral ischemia
* Homocysteine
* Methylenetetrahydrofolate reductase
* Neurodegeneration
* Sensorimotor cortex
* Supplementation
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104613
}}
==MTOR==
 
{{medline-entry
|title=The roles of [[MTOR]] and miRNAs in endothelial cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246301
 
 
|keywords=* Endothelium
* MTOR
* MicroRNAs
* Senescence
* Vascular aging
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09876-w
}}
{{medline-entry
|title=Autophagy drives fibroblast senescence through [[MTOR]]C2 regulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931659
 
 
|keywords=* Autophagy
* MTORC2
* myofibroblast
* rapamycin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595590
}}
{{medline-entry
|title=The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31795790
 
 
|keywords=* AMPK
* GID
* autophagy
* longevity
* primary cilium
* ubiquitination
|full-text-url=https://sci-hub.do/10.1080/15548627.2019.1695399
}}
==MTR==
 
{{medline-entry
|title=Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32269932
 
 
|keywords=* Aging
* amide proton transfer imaging
* biomarkers
* chemical exchange saturation transfer (CEST)
* molecular imaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136735
}}
==MUC7==
 
{{medline-entry
|title=Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31554163
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Cell Line
* Epithelial Cells
* Female
* Glycosylation
* Humans
* Male
* Middle Aged
* Mucins
* N-Acetylneuraminic Acid
* Plasmids
* Protein Binding
* Rheology
* Saliva
* Taste
* Young Adult
|keywords=* ageing
* mucin
* rheology
* saliva
* taste
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835954
}}
==MYB==
 
{{medline-entry
|title=Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31595958
 
|mesh-terms=* Arabidopsis
* Arabidopsis Proteins
* Gene Expression Profiling
* Gene Expression Regulation, Plant
* Plant Leaves
* Transcriptome
|keywords=*
          Phyllostachys edulis
       
* NAC
* postharvest
* regulatory factors
* shoot senescence
|full-text-url=https://sci-hub.do/10.1093/treephys/tpz100
}}
==MYC==
 
{{medline-entry
|title=Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32703451
 
 
|keywords=* Adipogenesis
* Adipose-derived stromal cells
* Senescence
* hTERT
* mTesR1
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.06.019
}}
==MYCN==
 
{{medline-entry
|title=Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920463
 
 
|keywords=* Aurora kinase A
* Cellular senescence
* MLN8237
* Neuroblastoma
* Small interfering RNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947931
}}
==MYSM1==
 
{{medline-entry
|title=[[MYSM1]] Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240758
 
 
|keywords=* DNA repair
* Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
* aging
* senescence
* senescence‐associated secretory phenotype (SASP)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055
}}
==MYT1==
 
{{medline-entry
|title=ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the [[MYT1]]-Egln3-Sirt1 Axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33038325
 
 
|keywords=* ESC-sEVs
* MYT1
* aging
* hippocampal NSCs
* senescence
|full-text-url=https://sci-hub.do/10.1016/j.ymthe.2020.09.037
}}
==NACA==
 
{{medline-entry
|title=Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699646
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Emergency Medical Services
* Female
* Humans
* Male
* Middle Aged
* Mountaineering
* Rescue Work
* Sex Factors
* Young Adult
|keywords=* MRT
* NACA ICAR
* SAR
* injury
* mechanism
|full-text-url=https://sci-hub.do/10.1016/j.wem.2019.06.016
}}
==NAMPT==
 
{{medline-entry
|title=Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32533606
 
 
|keywords=* ER stress
* NAD+
* NAMPT
* oxidative stress
* premature senescence
|full-text-url=https://sci-hub.do/10.1111/gtc.12794
}}
{{medline-entry
|title=Resistance training increases muscle NAD  and NADH concentrations as well as [[NAMPT]] protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369778
 
 
|keywords=* NAD +
* NADH
* aging
* muscle
* resistance training
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288928
}}
{{medline-entry
|title=Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase ([[NAMPT]]) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920356
 
 
|keywords=* NAMPT
* T2DM
* hNAA40
* nicotinamide phosphoribosyltransferase
* obesity
* senescence
* sirtuin-1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938199
}}
==NDRG2==
 
{{medline-entry
|title=[[NDRG2]] Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947996
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Antigens, CD
* Antigens, Differentiation, Myelomonocytic
* Astrocytes
* Brain
* DNA Damage
* Excitatory Amino Acid Transporter 2
* Gene Expression Regulation
* Glial Fibrillary Acidic Protein
* Glutamate-Ammonia Ligase
* Humans
* Microglia
* Neurofibrillary Tangles
* Tumor Suppressor Proteins
* tau Proteins
|keywords=* N-myc downstream regulated gene 2 (NDRG2)
* ageing brain
* astrocyte
* neurofibrillary tangles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982267
}}
==NDUFS8==
 
{{medline-entry
|title=Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32773682
 
|mesh-terms=* Aging
* Anesthetics, Inhalation
* Animals
* Animals, Genetically Modified
* Drosophila
* Electron Transport Complex I
* Isoflurane
* Male
* Mitochondria
* Mutation
* Sevoflurane
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494633
}}
==NEDD8==
 
{{medline-entry
|title=Targeting Protein Neddylation for Cancer Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31898235
 
|mesh-terms=* Animals
* Apoptosis
* Autophagy
* Cyclopentanes
* Humans
* NEDD8 Protein
* Neoplasms
* Pyrimidines
* Ubiquitin-Protein Ligases
* Ubiquitination
|keywords=* Apoptosis
* Autophagy
* Cancer target
* Inflammatory responses
* Neddylation
* Senescence
|full-text-url=https://sci-hub.do/10.1007/978-981-15-1025-0_18
}}
{{medline-entry
|title=Effective targeting of the ubiquitin-like modifier [[NEDD8]] for lung adenocarcinoma treatment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907687
 
 
|keywords=* NEDD8
* apoptosis
* cullin-RING ligases
* neddylation
* senescence
|full-text-url=https://sci-hub.do/10.1007/s10565-019-09503-6
}}
{{medline-entry
|title=Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665821
 
 
|keywords=* DNA re-replication
* MLN4924
* NAE-inhibitor
* canine
* melanoma
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473101
}}
==NEO1==
 
{{medline-entry
|title=Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i]  mouse long-term hematopoietic stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754028
 
|mesh-terms=* Aging
* Animals
* Female
* Hematopoietic Stem Cell Transplantation
* Hematopoietic Stem Cells
* Homeodomain Proteins
* Membrane Proteins
* Mice
* Mice, Transgenic
|keywords=* Neogenin-1
* aging
* hematopoietic stem cell
* myeloid bias
* transplantation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911217
}}
==NES==
 
{{medline-entry
|title=Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31891735
 
 
|keywords=* Aging
* Neuroendocrine system
* Nonhuman primate
|full-text-url=https://sci-hub.do/10.1016/j.pnpbp.2019.109854
}}
==NFKB1==
 
{{medline-entry
|title=[[NFKB1]] gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32002656
 
|mesh-terms=* Adult
* Allografts
* Disease-Free Survival
* Female
* Graft vs Host Disease
* Hematopoietic Stem Cell Transplantation
* Humans
* Male
* Middle Aged
* NF-kappa B p50 Subunit
* Pilot Projects
* Polymorphism, Single Nucleotide
* Survival Rate
|keywords=* Allogeneic hematopoietic stem cell transplantation
* Cellular senescence
* Graft-versus-host disease
* NFKB1 gene
* Senescence-associated secretory phenotype
* Single-nucleotide polymorphism
|full-text-url=https://sci-hub.do/10.1007/s00277-020-03935-5
}}
==NGF==
 
{{medline-entry
|title=Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32976934
 
 
|keywords=* Aging
* Anxiety-like behaviour
* Cognitive decline
* Hydrolysate
* Low molecular weight peptides
* Marine by-products
* Memory
* Navigation strategies
* Neuroinflammation
* Stress response
* n-3 Long chain polyunsaturated fatty acids (n-3 LC-PUFAs)
|full-text-url=https://sci-hub.do/10.1016/j.bbi.2020.09.022
}}
{{medline-entry
|title=Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32870355
 
 
|keywords=* Aging female
* MMP-7
* MMP-9
* Nerve growth factor
* Overactive bladder
* proNGF
|full-text-url=https://sci-hub.do/10.1007/s00345-020-03422-6
}}
{{medline-entry
|title=Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708332
 
 
|keywords=* aging
* corneal epithelial cell proliferation
* corneal sensitivity
* corneal sensory nerves
* mouse
* parity
* pregnancy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404034
}}
{{medline-entry
|title=Cholinergic System and [[NGF]] Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32575701
 
 
|keywords=* NTRK1/NTRKA
* aging
* cholinergic system
* fish
* p75/NGFR
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348706
}}
{{medline-entry
|title=Retrograde axonal transport of BDNF and pro[[NGF]] diminishes with age in basal forebrain cholinergic neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574357
 
|mesh-terms=* Aging
* Alzheimer Disease
* Axonal Transport
* Brain-Derived Neurotrophic Factor
* Cholinergic Neurons
* Humans
* Nerve Growth Factor
* Prosencephalon
|keywords=* Alzheimer's disease
* Axonal transport
* Basal forebrain
* Neurodegeneration
* Neurotrophins
* Trk receptors
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.07.018
}}
{{medline-entry
|title=C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481652
 
|mesh-terms=* Aging
* Animals
* Blood Glucose
* Class I Phosphatidylinositol 3-Kinases
* Class Ia Phosphatidylinositol 3-Kinase
* Female
* Forkhead Transcription Factors
* Insulin
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Nerve Growth Factor
* Oxidative Stress
* PC12 Cells
* Platelet-Derived Growth Factor
* Point Mutation
* Proto-Oncogene Proteins c-akt
* Rats
* src Homology Domains
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722097
}}
==NHS==
 
{{medline-entry
|title=Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965237
 
 
|keywords=* acute coronary syndrome
* coronary heart disease
* immunosenescence
* telomerase activator
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542409
}}
{{medline-entry
|title=Factors associated with COVID-19-related death using OpenSAFELY.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32640463
 
|mesh-terms=* Adolescent
* Adult
* African Continental Ancestry Group
* Age Distribution
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Asian Continental Ancestry Group
* Asthma
* Betacoronavirus
* COVID-19
* Cohort Studies
* Coronavirus Infections
* Diabetes Mellitus
* Female
* Humans
* Hypertension
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* Proportional Hazards Models
* Risk Assessment
* SARS-CoV-2
* Sex Characteristics
* Smoking
* State Medicine
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2521-4
}}
{{medline-entry
|title=Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32548985
 
 
|keywords=* advanced practice
* gerontology
* older people
* patient outcomes
* patients
* practice development
* professional
* professional issues
* quality of life
|full-text-url=https://sci-hub.do/10.7748/nop.2020.e1229
}}
{{medline-entry
|title=Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31817147
 
|mesh-terms=* Cross-Sectional Studies
* Gross Domestic Product
* Health Care Rationing
* Health Expenditures
* Humans
* Latent Class Analysis
* Least-Squares Analysis
* Life Expectancy
* Patient Safety
* Patient Satisfaction
* Spain
* State Medicine
|keywords=* National Health Service
* health policy
* partial least squares structural equation modeling (PLS-SEM)
* patient satisfaction
* quality of healthcare
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950388
}}
{{medline-entry
|title=Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31748285
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Comorbidity
* Diabetes Mellitus
* Echocardiography
* Exercise Tolerance
* Female
* Heart Failure
* Heart Ventricles
* Humans
* Hypertension
* Male
* Observational Studies as Topic
* Prospective Studies
* Pulse Wave Analysis
* Research Design
* Stroke Volume
* Vascular Stiffness
|keywords=* arterial stiffness
* comorbidities
* heart failure with preserved ejection fraction
* pathophysiology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886989
}}
{{medline-entry
|title=Challenges to concordance: theories that explain variations in patient responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31604052
 
|mesh-terms=* Aging
* Benchmarking
* Communication Barriers
* Community Health Nursing
* Humans
* Nurse-Patient Relations
* State Medicine
* United Kingdom
|keywords=* Concordance
* Decision making
* Person-centred care
* Psychological theories
* Self-management
|full-text-url=https://sci-hub.do/10.12968/bjcn.2019.24.10.466
}}
{{medline-entry
|title=Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31451635
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Female
* Health Behavior
* Humans
* Logistic Models
* Longevity
* Longitudinal Studies
* Male
* Middle Aged
* Odds Ratio
|keywords=* aging
* longevity
* longitudinal study
* optimism
* psychological well-being
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744861
}}
==NKAP==
 
{{medline-entry
|title=[[NKAP]] Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31632967
 
 
|keywords=* NKAP
* apoptosis
* cyclin dependent kinase inhibitor
* hematopoiesis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783958
}}
==NKX6-1==
 
{{medline-entry
|title=The dynamic methylome of islets in health and disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500828
 
|mesh-terms=* Animals
* Cell Differentiation
* DNA Methylation
* Diabetes Mellitus, Type 2
* Epigenome
* Humans
* Insulin-Secreting Cells
|keywords=* Aging
* Beta cells
* DNA methylation
* Endocrine pancreas
* Epigenetics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768570
}}
==NLRC4==
 
{{medline-entry
|title=Hyperglycemia-induced inflamm-aging accelerates gingival senescence via [[NLRC4]] phosphorylation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31676687
 
|mesh-terms=* Aging
* Animals
* Apoptosis Regulatory Proteins
* Blotting, Western
* Calcium-Binding Proteins
* Cellular Senescence
* Clustered Regularly Interspaced Short Palindromic Repeats
* Gingiva
* Glucose
* Hyperglycemia
* Immunohistochemistry
* Inflammation
* Interferon Regulatory Factors
* Male
* Mice
* Mice, Inbred C57BL
* RAW 264.7 Cells
* Signal Transduction
|keywords=* NLRC4
* SASP
* aging
* cellular senescence
* diabetes
* gingiva
* hyperglycemia
* inflamm-aging
* inflammasome
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901307
}}
==NLRP12==
 
{{medline-entry
|title=Persistent DNA damage-induced [[NLRP12]] improves hematopoietic stem cell function.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434992
 
 
|keywords=* Aging
* DNA repair
* Hematology
* Hematopoietic stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259522
}}
==NLRP3==
 
{{medline-entry
|title=Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269094
 
 
|keywords=* adaptive immunity
* aging
* innate immunity
* longevity
* resilience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673842
}}
{{medline-entry
|title=TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33113366
 
 
|keywords=* CHIP
* IL-1β
* TET2
* adipose tissue
* aging
* clonal hematopoiesis
* diabetes
* insulin resistance
* obesity
* somatic mutations
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2020.108326
}}
{{medline-entry
|title=Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and [[NLRP3]] inflammasome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33115643
 
 
|keywords=* Aging
* Apoptosis
* NOD-like receptor protein 3 inflammasome
* Neuroinflammation
* Postoperative cognitive dysfunction
* Propofol
|full-text-url=https://sci-hub.do/10.1016/j.neulet.2020.135461
}}
{{medline-entry
|title=A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066043
 
 
|keywords=* ASC and pannexin 1
* MYC G4-quadruplex stabilizer
* NLRP3
* caspase 1
* endoplasmic reticulum stress
* gasdermin D
* inflammasome
* pyroptosis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650714
}}
{{medline-entry
|title=Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013631
 
 
|keywords=* Alzheimer's disease
* amyloid β
* astrocyte
* interleukin-1β
* neuroinflammation
* senescence
* tau
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493674
}}
{{medline-entry
|title=Mechanisms of [[NLRP3]] priming in inflammaging and age related diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32883606
 
 
|keywords=* Aging
* Inflammaging
* Inflammasome
* NLRP3
* Priming
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571497
}}
{{medline-entry
|title=Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32855848
 
 
|keywords=* NLRP3 inflammasome
* age-related macular degeneration
* lamivudine
* retinal pigment epithelium
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422901
}}
{{medline-entry
|title=The [[NLRP3]] Inflammasome: Metabolic Regulation and Contribution to Inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751530
 
 
|keywords=* NLRP3 inflammasome
* aging
* inflammation
* metabolism
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463618
}}
{{medline-entry
|title=Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated [[NLRP3]] activation in macrophages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666684
 
 
|keywords=* aging
* and reperfusion injury
* leucine-rich repeat containing protein 3
* liver ischemia
* macrophage immune response
* nucleotide-binding domain
* stimulator of interferon genes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431827
}}
{{medline-entry
|title=Targeting [[NLRP3]] Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531176
 
 
|keywords=* aging
* inflammasomes
* inflammation
* macrophages
* osteoclasts
* periodontitis
|full-text-url=https://sci-hub.do/10.1177/0022034520933533
}}
{{medline-entry
|title=Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and [[NLRP3]] Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32331214
 
 
|keywords=* Korean ginseng extract
* NLRP3 inflammasome
* aging
* ovary
* oxidative stress response
* subfertility
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231237
}}
{{medline-entry
|title=Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337948
 
|mesh-terms=* Aging
* Animals
* Benzylisoquinolines
* Brain
* Dexmedetomidine
* Inflammasomes
* Inflammation
* Male
* Mitochondria
* Oxidative Stress
* Rats, Sprague-Dawley
* Reactive Oxygen Species
|keywords=*  dementia
*  dexmedetomidine
*  inflammasomes
*  β-amyloid
* cepharanthine
|full-text-url=https://sci-hub.do/10.5114/fn.2019.89855
}}
{{medline-entry
|title=Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and [[NLRP3]] inflammasome activation in SAMP8 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32114413
 
 
|keywords=* Ginsenoside Rg1
* Kidney aging
* NADPH oxidase 4 (NOX4)
* NLRP3 inflammasome
* Renal fibrosis
|full-text-url=https://sci-hub.do/10.1016/j.intimp.2020.106339
}}
{{medline-entry
|title=Blockade of the [[NLRP3]] inflammasome improves metabolic health and lifespan in obese mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31975052
 
 
|keywords=* Aging
* Autophagy
* High-fat diet
* Longevity
* NLRP3 inflammasome
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206474
}}
{{medline-entry
|title=Autophagy and [[NLRP3]] inflammasome crosstalk in neuroinflammation in aged bovine brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31903559
 
 
|keywords=* NLRP3 inflammasome
* aging
* autophagy
* bovine
* immunosenescence
* neuroinflammation
|full-text-url=https://sci-hub.do/10.1002/jcp.29426
}}
{{medline-entry
|title=[[NLRP3]] Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31603987
 
 
|keywords=* Aging
* Autophagy
* MCC950
* NLRP3 inflammasome
* PPARα
|full-text-url=https://sci-hub.do/10.1093/gerona/glz239
}}
{{medline-entry
|title=[[NLRP3]] inflammasome suppression improves longevity and prevents cardiac aging in male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31625260
 
 
|keywords=* NLRP3-inflammasome
* autophagy
* cardiac aging
* longevity
* morbidity
* mortality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974709
}}
{{medline-entry
|title=Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494646
 
|mesh-terms=* Aging
* Animals
* Cellular Senescence
* Endothelial Progenitor Cells
* Mice
* NF-E2-Related Factor 2
* NF-kappa B
* NLR Family, Pyrin Domain-Containing 3 Protein
* Neovascularization, Physiologic
* Oxidative Stress
|keywords=* NLRP3 inflammasome
* NRF2
* aging
* endothelial progenitor cells
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756903
}}
{{medline-entry
|title=Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468381
 
|mesh-terms=* Aging
* Animals
* Brain
* Membrane Glycoproteins
* Membrane Transport Proteins
* Mice
* Mice, Inbred C57BL
* Taurine
|keywords=* Age-related diseases
* Glycine Transporter (GLYT)
* NLRP3
* Taurine Transporter (TauT)
|full-text-url=https://sci-hub.do/10.1007/978-981-13-8023-5_1
}}
==NMI==
 
{{medline-entry
|title=Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31825888
 
 
|keywords=* activity of daily living
* aging
* functional connectivity
* motor variability
* muscle fatigue
|full-text-url=https://sci-hub.do/10.1123/japa.2019-0055
}}
==NMS==
 
{{medline-entry
|title=Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665234
 
 
|keywords=* Aging
* Dynapenia
* Glycated hemoglobin
* Hyperglycemia
* Neuromuscular strength
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243578
}}
==NMUR1==
 
{{medline-entry
|title=[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31685733
 
|mesh-terms=* Aging
* Chemistry, Pharmaceutical
* Drug Discovery
* Humans
* Life Style
* Molecular Targeted Therapy
* Muscle Weakness
* Muscular Atrophy
* Myostatin
* Neuropeptides
* Obesity
* Peptides
* Receptors, Neurotransmitter
* Structure-Activity Relationship
|keywords=* myostatin inhibitor
* neuromedin U receptor-selective agonist
* peptide
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00149
}}
==NNT==
 
{{medline-entry
|title=Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814012
 
 
|keywords=* Outcomes
* Physical activity
* Successful aging
* Systematic review
|full-text-url=https://sci-hub.do/10.1093/gerona/glz284
}}
{{medline-entry
|title=Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647578
 
|mesh-terms=* Aged
* Aged, 80 and over
* Case-Control Studies
* Databases, Factual
* Female
* Humans
* Hydroxymethylglutaryl-CoA Reductase Inhibitors
* Male
* Myocardial Infarction
* Proportional Hazards Models
* Retrospective Studies
* Risk Assessment
* Secondary Prevention
* Stroke
|keywords=* geriatrics
* myocardial infarction
* secondary prevention
* statin
* time varying
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028025
}}
==NOP10==
 
{{medline-entry
|title=Pseudouridylation defect due to [i]DKC1[/i] and [i][[NOP10]][/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554502
 
|mesh-terms=* Animals
* Cataract
* Cell Cycle Proteins
* Child
* Enterocolitis
* Female
* Genetic Predisposition to Disease
* Hearing Loss, Sensorineural
* Humans
* Longevity
* Male
* Models, Molecular
* Molecular Dynamics Simulation
* Mutation
* Nephrotic Syndrome
* Nuclear Proteins
* Pedigree
* Protein Conformation
* RNA, Ribosomal
* Ribonucleoproteins, Small Nucleolar
* Zebrafish
|keywords=* H/ACA snoRNP
* pediatrics
* pseudouridylation
* rRNA
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334496
}}
==NOS1==
 
{{medline-entry
|title=Prepubertal overexposure to manganese induce precocious puberty through GABA  receptor/nitric oxide pathway in immature female rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711775
 
|mesh-terms=* Aging
* Animals
* Chlorides
* Endocrine Disruptors
* Female
* Gonadotropin-Releasing Hormone
* Manganese Compounds
* Neurons
* Nitric Oxide
* Ovary
* Preoptic Area
* Rats
* Rats, Sprague-Dawley
* Receptors, GABA-A
* Sexual Maturation
* Signal Transduction
* Uterus
* Weaning
|keywords=* GABA(A)R
* GnRH
* Manganese
* Nitric oxide
* Precocious puberty
|full-text-url=https://sci-hub.do/10.1016/j.ecoenv.2019.109898
}}
==NOS3==
 
{{medline-entry
|title=Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455928
 
 
|keywords=* endothelial cells
* oxidative stress
* senescence
* tissue-engineered blood vessel
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290800
}}
==NOTCH1==
 
{{medline-entry
|title=[How Does Aging Contribute to Cancer?]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33130684
 
|mesh-terms=* Aged
* Aging
* Carcinogenesis
* Esophageal Neoplasms
* Humans
* Mutation
 
 
}}
{{medline-entry
|title=H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31609547
 
|mesh-terms=* Aging
* Animals
* Aortic Valve
* Aortic Valve Stenosis
* Calcinosis
* DNA Methylation
* Female
* Male
* Mice
* Mice, Inbred C57BL
* RNA, Long Noncoding
* Sex Factors
* Up-Regulation
|keywords=*
H19
 
* age
* calcific aortic valve disease
* epigenetics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778597
}}
==NOTCH4==
 
{{medline-entry
|title=Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920157
 
 
|keywords=* Aging
* DLK
* LC3
* Notch signaling
* autophagy
* axon injury
* axon regeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595581
}}
==NOX4==
 
{{medline-entry
|title=Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33227845
 
 
|keywords=* NOX4
* Reactive oxygen species
* Senescence
* Sestrin2
|full-text-url=https://sci-hub.do/10.4235/agmr.20.0051
}}
==NPM1==
 
{{medline-entry
|title=Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31784606
 
|mesh-terms=* Animals
* Cell Line
* Cell Proliferation
* Cell Separation
* Culture Media
* Flow Cytometry
* Longevity
* Macrophage Colony-Stimulating Factor
* Macrophages
* Mole Rats
* Recombinant Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884578
}}
==NPR1==
 
{{medline-entry
|title=The [[NPR1]]-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33270345
 
 
|keywords=* Leaf senescence
* NPR1
* Probenazole
* Salicylic acid
* WRKY46
* WRKY6
|full-text-url=https://sci-hub.do/10.1111/jipb.13044
}}
{{medline-entry
|title=Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32540002
 
 
|keywords=* Early senescence
* H(+)/Ca(2+)exchanger 1
* Plant defense
* Salicylic acid
* Scopoletin
|full-text-url=https://sci-hub.do/10.1016/j.plantsci.2020.110472
}}
==NPW==
 
{{medline-entry
|title=Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32309980
 
|mesh-terms=* Aged
* Aging
* Cognition
* Cognitive Aging
* Cognitive Dysfunction
* Employment
* Female
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Retirement
* Time
 
|full-text-url=https://sci-hub.do/10.1037/pag0000468
}}
==NPY==
 
{{medline-entry
|title=Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012215
 
 
|keywords=* Autophagy
* Caloric restriction mimetic
* Cellular senescence
* Human aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243588
}}
{{medline-entry
|title=Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31855319
 
|mesh-terms=* Animals
* Caloric Restriction
* Dietary Supplements
* Drugs, Chinese Herbal
* Female
* Ghrelin
* Longevity
* Male
* Mice
* Mice, Knockout
* Oxidative Stress
|keywords=* calorie restriction
* ghrelin
* longevity
* metabolism
* oxidative stress
|full-text-url=https://sci-hub.do/10.1111/ggi.13848
}}
==NRAS==
 
{{medline-entry
|title=Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32558183
 
 
|keywords=* biliary epithelial cell
* cellular senescence
* extracellular vesicles
* primary sclerosing cholangitis
* senescence-associated secretory phenotype
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669612
}}
{{medline-entry
|title=STAT3 Relays a Differential Response to Melanoma-Associated [i][[NRAS]][/i] Mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906480
 
 
|keywords=* NRAS
* STAT3
* melanoma
* mutation
* oncogene-induced senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016650
}}
{{medline-entry
|title=Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703632
 
|mesh-terms=* Animals
* Apoptosis
* Carcinogenesis
* Cell Differentiation
* DNA (Cytosine-5-)-Methyltransferases
* Disease Models, Animal
* Disease Progression
* Gene Expression Regulation, Neoplastic
* Gene Knock-In Techniques
* Leukemia, Myeloid, Acute
* Longevity
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Monomeric GTP-Binding Proteins
* Mutation
* Phenotype
* Pilot Projects
* Proto-Oncogene Proteins c-myc
* RNA-Seq
* Transcription, Genetic
|keywords=* Acute myeloid leukemia
* DNMT3A mutation
* Myc activation
* Nras G12D
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842226
}}
==NRL==
 
{{medline-entry
|title=Development of a cyclophosphamide stress test to predict resilience to aging in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32613492
 
 
|keywords=* Aging mice
* Cyclophosphamide
* Neutrophil lymphocyte ratio
* Resilience to aging
* Stress test
* WBC count
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00222-z
}}
==NRM==
 
{{medline-entry
|title=Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31445185
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Autografts
* Female
* Hematopoiesis
* Hematopoietic Stem Cell Transplantation
* Humans
* Lymphoma, Non-Hodgkin
* Male
* Middle Aged
* Multiple Myeloma
* Retrospective Studies
|keywords=* Autologous
* Clonal hematopoiesis
* Lymphoma
* Multiple myeloma
* Nonrelapse mortality
* Survivors
* Transplantation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192097
}}
==NSF==
 
{{medline-entry
|title=Effects of air pollution on children from a socioecological perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727016
 
|mesh-terms=* Air Pollution
* Child Mortality
* Child, Preschool
* Environment
* Humans
* Income
* Infant
* Life Expectancy
* Retrospective Studies
* Socioeconomic Factors
* Sociological Factors
|keywords=* Deaths of children under age 5
* Electrification rates
* Income
* Inequality in life expectancy
* Natural resource depletion
* Non-solid fuel
* Outdoor and indoor air pollution
* Socioecological perspective
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857293
}}
==NT5E==
 
{{medline-entry
|title=The [[NT5E]] gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31401370
 
|mesh-terms=* 5'-Nucleotidase
* Animals
* Cattle
* Diaphragm
* Food Handling
* Inosine Monophosphate
* Muscle, Skeletal
* Polymorphism, Single Nucleotide
* Postmortem Changes
* Red Meat
* Taste
|keywords=* Inosine 5′-monophosphate
* Japanese Black beef
* Meat quality
* NT5E
* Postmortem aging
|full-text-url=https://sci-hub.do/10.1016/j.meatsci.2019.107893
}}
==NTHL1==
 
{{medline-entry
|title=Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970600
 
 
|keywords=* AP endonuclease
* Aging
* DNA glycosylases
* DNA repair
* Mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205949
}}
==NUCB2==
 
{{medline-entry
|title=Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906085
 
 
|keywords=* Nesf-1
* Nothobranchius furzeri
* aging
* brain-gut axis
* vertebrate
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019235
}}
==OGA==
 
{{medline-entry
|title=NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747588
 
|mesh-terms=* Aging
* Amyotrophic Lateral Sclerosis
* Animals
* Female
* Humans
* Mice
* Mice, Mutant Strains
* Motor Neurons
* Muscle Denervation
* Oxidative Stress
* Paralysis
* beta-N-Acetylhexosaminidases
|keywords=* ALS
* NPGPx
* O-GlcNAcylation
* OGA
* aging
* motor neuron
* oxidative stress
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.10.053
}}
==OGG1==
 
{{medline-entry
|title=Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783583
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* DNA, Mitochondrial
* Female
* Homeostasis
* Humans
* Inflammation
* Iron
* Male
* Mitochondria, Muscle
* Quadriceps Muscle
* Young Adult
|keywords=* ZIP
* ferritin
* hepcidin
* inflammation
* iron overload
* mitochondrial dysfunction
* mtDNA
* muscle aging
* physical performance
* transferrin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953082
}}
==OGT==
 
{{medline-entry
|title=ELT-2 promotes O-GlcNAc transferase [[OGT]]-1 expression to modulate Caenorhabditis elegans lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32628333
 
 
|keywords=* Caenorhabditis elegans
* GATA factor ELT-2
* OGT-1
* lifespan
|full-text-url=https://sci-hub.do/10.1002/jcb.29817
}}
{{medline-entry
|title=Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588002
 
|mesh-terms=* Acetylglucosamine
* Acylation
* Aging
* Animals
* Cognition
* Male
* Mice
* Mice, Knockout
* N-Acetylglucosaminyltransferases
|keywords=* O-GlcNAcylation
* OGT
* aging
* brain
* cognition
* hippocampus
* rejuvenation
* synaptic plasticity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199460
}}
==OSM==
 
{{medline-entry
|title=Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143546
 
 
|keywords=* LGBT
* Sexual minorities
* cohort differences
* discrimination
* friendship aging
* internalized homonegativity
* minority stress
* outness
* social support
|full-text-url=https://sci-hub.do/10.1080/07317115.2020.1836107
}}
==OTC==
 
{{medline-entry
|title=Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644599
 
|mesh-terms=* Aging
* Animals
* Bass
* Ecosystem
* Environmental Monitoring
* Population Dynamics
* Reproduction
* Rivers
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808449
}}
==P2RY12==
 
{{medline-entry
|title=Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33261619
 
 
|keywords=* Aging
* Brain infiltrating myeloid cells
* CD45
* Cerebral amyloid angiopathy
* Microglia
* Neuroinflammation
* P2RY12
* Stroke
* Tmem119
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709276
}}
{{medline-entry
|title=Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32958210
 
 
|keywords=* Aging
* CD68
* Glaucoma
* Iba-1
* Inflammation
* MHCII
* Microglia
* Mouse
* Ocular hypertension
* P2RY12
* Retina
|full-text-url=https://sci-hub.do/10.1016/bs.pbr.2020.05.024
}}
{{medline-entry
|title=Patterns of Expression of Purinergic Receptor [[P2RY12]], a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31968618
 
|mesh-terms=* Aging
* Alzheimer Disease
* Biomarkers
* Brain
* Humans
* Immunohistochemistry
* Inflammation
* Macrophages
* Microglia
* Phenotype
* Plaque, Amyloid
* Receptors, Purinergic P2Y2
|keywords=* Alzheimer’s disease
* activation phenotypes
* amyloid
* immunohistochemistry
* microglia
* neuroinflammation
* temporal cortex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014248
}}
==P4HA2==
 
{{medline-entry
|title=Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31560770
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Asian Continental Ancestry Group
* Axial Length, Eye
* Child
* Child, Preschool
* China
* Cross-Sectional Studies
* DNA Mutational Analysis
* Female
* Genetic Association Studies
* Genotype
* Humans
* Male
* Middle Aged
* Myopia, Degenerative
* Phenotype
* Retinal Diseases
* Vision, Low
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1167/iovs.19-27921
}}
==P4HA3==
 
{{medline-entry
|title=Age-associated genes in human mammary gland drive human breast cancer progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539762
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Animals
* Biomarkers, Tumor
* Breast
* Breast Neoplasms
* Disease Progression
* Dyneins
* Female
* Gene Expression Regulation, Neoplastic
* Heterografts
* Humans
* Mice
* Mice, Inbred NOD
* Mice, SCID
* Middle Aged
* Procollagen-Proline Dioxygenase
* Prognosis
* Survival Rate
* Tumor Cells, Cultured
|keywords=* ALX4
* Aging
* Breast cancer
* DYNLT3
* Gene expression
* P4HA3
* Relapse-free survival
* Transcriptomics
* Tumor progression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294649
}}
==PAH==
 
{{medline-entry
|title=Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32771846
 
|mesh-terms=* Aerosols
* Biomass
* Carbon
* Ozone
* Smog
* Soot
|keywords=* Absorption Ångström exponent
* Brown carbon
* Light absorption
* Ozone aging
* Soot particles
|full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.115273
}}
{{medline-entry
|title=Factors associated with pulmonary arterial hypertension ([[PAH]]) in systemic sclerosis (SSc).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659476
 
|mesh-terms=* Aging
* Humans
* Natriuretic Peptide, Brain
* Pulmonary Arterial Hypertension
* Risk Factors
* Scleroderma, Systemic
 
|full-text-url=https://sci-hub.do/10.1016/j.autrev.2020.102602
}}
{{medline-entry
|title=Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32316707
 
 
|keywords=* Aging
* Dementia
* Long-Term Care
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509129
}}
==PAM==
 
{{medline-entry
|title=Relationship between patient activation measurement and self-rated health in patients with chronic diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148185
 
 
|keywords=* Aging population
* Chronic diseases
* Patient activation measurement
* Primary health care
* Self-rated health
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643260
}}
{{medline-entry
|title=Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068001
 
 
|keywords=* GABA
* aging
* cognition
* neurotrophic effect
* positive allosteric modulator
|full-text-url=https://sci-hub.do/10.1093/cercor/bhaa310
}}
{{medline-entry
|title=The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330742
 
|mesh-terms=* Aging
* Aging, Premature
* Animals
* Behavior, Animal
* Female
* Housing, Animal
* Longevity
* Lymphocytes
* Macrophages
* Mice
* Oxidative Stress
* Social Environment
|keywords=* Behavior
* Immunity
* Mean lifespan
* Prematurely aging mice
* Social environmental strategy
|full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577240
}}
==PAX8==
 
{{medline-entry
|title=Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518338
 
|mesh-terms=* Aging
* Animals
* Fatty Liver
* Insulin Resistance
* Liver
* Liver Neoplasms
* Male
* Mice
* Mice, Knockout
* PAX8 Transcription Factor
* Thyroid Hormones
|keywords=* glucose metabolism
* healthspan
* hyperthyroidism
* hypothyroidism
* lifespan
* thyroid hormones
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781991
}}
==PBX1==
 
{{medline-entry
|title=Internalization of the TAT-[[PBX1]] fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436118
 
 
|keywords=* AKT
* Hair follicle mesenchymal stem cells
* PBX1
* Protein purification
* Senescence
* TAT
|full-text-url=https://sci-hub.do/10.1007/s10529-020-02909-x
}}
==PC==
 
{{medline-entry
|title=Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103379
 
 
|keywords=* Aging
* Behaviour change
* Physical functioning
* Protein
* Sarcopenia
* e-Health
|full-text-url=https://sci-hub.do/10.1002/jcsm.12634
}}
{{medline-entry
|title=Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32980983
 
 
|keywords=* Aging
* Diastolic function
* Phase-contrast MRI
* Right ventricle
|full-text-url=https://sci-hub.do/10.1007/s10554-020-02040-y
}}
{{medline-entry
|title=Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32668433
 
 
|keywords=* Deep brain stimulation
* Dystonia
* Globus pallidus internus
* Pulse generator longevity
* Pulse width
|full-text-url=https://sci-hub.do/10.1159/000508794
}}
{{medline-entry
|title=Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32576518
 
 
|keywords=* Adverse events
* Chemotherapy
* Gemcitabine
* Geriatrics
* Nab-paclitaxel
* Pancreatic cancer
|full-text-url=https://sci-hub.do/10.1016/j.jgo.2020.06.017
}}
{{medline-entry
|title=Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314935
 
 
|keywords=* 17-β-Oestradiol
* aging
* oxidative stress
* phytoestrogen
* surfactant
* type ii pneumocytes
|full-text-url=https://sci-hub.do/10.1080/09637486.2020.1757044
}}
{{medline-entry
|title=Pacing During 200-m Competitive Masters Swimming.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32271289
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Athletes
* Athletic Performance
* Competitive Behavior
* Female
* Humans
* Male
* Middle Aged
* Sex Factors
* Swimming
 
|full-text-url=https://sci-hub.do/10.1519/JSC.0000000000003621
}}
{{medline-entry
|title=Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32212232
 
 
|keywords=* aging
* behavioral risk factors
* geriatric oncology
* healthy aging
* prostate cancer survivorship
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221418
}}
{{medline-entry
|title=Extracranial versus intracranial hydro-hemodynamics during aging: a [[PC]]-MRI pilot cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931818
 
|mesh-terms=* Aged
* Aged, 80 and over
* Brain
* Cerebral Ventricles
* Cerebrospinal Fluid
* Cerebrovascular Circulation
* Cross-Sectional Studies
* Female
* Hemodynamics
* Humans
* Magnetic Resonance Imaging
* Male
* Middle Aged
|keywords=* Aging
* Arterial cerebral blood flow
* CSF flow
* PC-MRI
* Pulsatility
* Venous cerebral blood flow
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958565
}}
{{medline-entry
|title=Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736000
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aging
* Cancer Survivors
* Case-Control Studies
* Disease-Free Survival
* Germany
* Humans
* Male
* Middle Aged
* Prostatic Neoplasms
* Quality of Life
* Surveys and Questionnaires
* Young Adult
|keywords=* Health-related quality of life
* Long-term survivor
* Population-based
* Prostate cancer
|full-text-url=https://sci-hub.do/10.1007/s00520-019-05120-5
}}
{{medline-entry
|title=Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553876
 
|mesh-terms=* Animals
* Antineoplastic Agents
* Apoptosis
* Cell Line, Tumor
* Cellular Senescence
* Docetaxel
* Forkhead Box Protein O1
* Humans
* Male
* Mice
* Mice, Nude
* Nanostructures
* Polyphenols
* Prostatic Neoplasms
* Receptor, Transforming Growth Factor-beta Type I
* Signal Transduction
* Tannins
* Transplantation, Heterologous
|keywords=* DSAs
* apoptosis
* docetaxel
* nanoassemblies
* prostate cancer
* senescence
|full-text-url=https://sci-hub.do/10.1021/acsami.9b14738
}}
{{medline-entry
|title=An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31482851
 
 
|keywords=* cognition
* dementia
* healthy aging
* memory
* virtual reality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751096
}}
==PCNA==
 
{{medline-entry
|title=Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33223510
 
 
|keywords=* BER
* Pol β
* menopause
* oocytes
* ovarian aging
|full-text-url=https://sci-hub.do/10.18632/aging.104123
}}
{{medline-entry
|title=[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362082
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Child
* Child, Preschool
* Dermis
* Female
* Fibroblasts
* HSP90 Heat-Shock Proteins
* Humans
* Infant
* Infant, Newborn
* Middle Aged
* Pregnancy
* Young Adult
|keywords=* HSP90
* PCNA
* aging
* fibroblasts
* skin
 
}}
{{medline-entry
|title=A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32295227
 
 
|keywords=* Argentatin A
* PCNA
* antiproliferative
* antitumor
* apoptosis
* cell senescence
* colon cancer
* xenografts
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221627
}}
{{medline-entry
|title=[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145162
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Child
* Child, Preschool
* Dermis
* Female
* Fibroblasts
* Humans
* Infant
* Infant, Newborn
* Middle Aged
* Pregnancy
* Protein-Serine-Threonine Kinases
* Skin Aging
* Trans-Activators
* Young Adult
|keywords=* CD31
* PCNA
* TAZ
* aging
* blood vessels
* fibroblasts
* skin
 
}}
{{medline-entry
|title=[Mechanosensitive Yes-associated protein in human skin during aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800177
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Adult
* Aged
* Aged, 80 and over
* Aging
* Dermis
* Endothelial Cells
* Female
* Fibroblasts
* Humans
* Middle Aged
* Pregnancy
* Skin Aging
* Transcription Factors
|keywords=* CD31
* PCNA
* YAP
* aging
* blood vessels
* fibroblasts
* skin
 
}}
{{medline-entry
|title=[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512421
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Blood Vessels
* Child
* Child, Preschool
* Dermis
* Female
* Fibroblasts
* Humans
* Infant
* Ion Channels
* Male
* Middle Aged
* Platelet Endothelial Cell Adhesion Molecule-1
* Pregnancy
* Proliferating Cell Nuclear Antigen
* Skin Aging
|keywords=* CD31
* PCNA
* Piezo1
* aging
* blood vessels
* fibroblasts
* skin
 
}}
==PCSK9==
 
{{medline-entry
|title=Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011347
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoproteins B
* Atherosclerosis
* Cardiovascular Diseases
* Cardiovascular System
* Cholesterol
* Humans
* Lipid Metabolism
* Lipoproteins
* Lipoproteins, LDL
* Risk Factors
 
|full-text-url=https://sci-hub.do/10.1097/MED.0000000000000529
}}
{{medline-entry
|title=The role of proprotein convertase subtilisin-kexin type 9 ([[PCSK9]]) in the vascular aging process - is there a link?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31708986
 
 
|keywords=* PCSK9
* atherosclerosis
* cholesterol
* inflammation
* vascular aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836637
}}
==PDCD4==
 
{{medline-entry
|title=Petal abscission in roses is associated with the activation of a truncated version of the animal [[PDCD4]] homologue, RbPCD1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521226
 
|mesh-terms=* Amino Acid Sequence
* Arabidopsis
* Gene Expression Regulation, Plant
* Plant Proteins
* Plants, Genetically Modified
* Programmed Cell Death 1 Receptor
* Rosa
* Sequence Alignment
* Transcription Factors
|keywords=* Ethylene
* Heat shock
* Inflorescence
* MA3 domain
* PDCD4
* Repression
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.plantsci.2019.110242
}}
==PDE2A==
 
{{medline-entry
|title=TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521738
 
|mesh-terms=* Aging
* Animals
* Brain
* Cognition
* Cognition Disorders
* Cognitive Dysfunction
* Cyclic AMP
* Cyclic GMP
* Cyclic Nucleotide Phosphodiesterases, Type 2
* Male
* Memory Disorders
* Memory, Episodic
* Phosphodiesterase Inhibitors
* Pyrazines
* Pyridines
* Rats
* Rats, Inbred F344
* Rats, Long-Evans
* Rats, Sprague-Dawley
|keywords=* Aging
* Cognition
* PDE2A
* TAK-915
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2019.112192
}}
==PDE4D==
 
{{medline-entry
|title=Phosphodiesterase [[PDE4D]] Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33192469
 
 
|keywords=* Alzheimer’s disease
* PDE4D
* aging
* tau
* working memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655962
}}
==PDE5A==
 
{{medline-entry
|title=Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32513693
 
|mesh-terms=* Aging
* Animals
* Bone Density
* Bone and Bones
* Brain
* Cell Differentiation
* Cyclic Nucleotide Phosphodiesterases, Type 5
* Drug Repositioning
* Erectile Dysfunction
* Humans
* Male
* Mice
* Middle Aged
* Models, Animal
* Models, Molecular
* Neurons
* Osteoblasts
* Osteoclasts
* Osteogenesis
* Osteoporosis
* Osteoporotic Fractures
* Phosphodiesterase 5 Inhibitors
* Primary Cell Culture
* Tadalafil
* Vardenafil Dihydrochloride
|keywords=* PDE5 inhibitor
* computational modeling
* cyclic GMP
* osteoporosis
* resorption
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321982
}}
==PDK1==
 
{{medline-entry
|title=Inhibition of 3-phosphoinositide-dependent protein kinase 1 ([[PDK1]]) can revert cellular senescence in human dermal fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33229519
 
 
|keywords=* PDK1
* cellular senescence
* network modeling
* skin aging
* systems biology
|full-text-url=https://sci-hub.do/10.1073/pnas.1920338117
}}
{{medline-entry
|title=The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged [[PDK1]] K465E Knock-In Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32457586
 
 
|keywords=* PI3K/Akt
* RDoC
* aging
* animal model
* anxiety
* cognition
* fine tuning
* signaling pathway
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225327
}}
==PER1==
 
{{medline-entry
|title=Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31773385
 
|mesh-terms=* ARNTL Transcription Factors
* Age Factors
* Aging
* CLOCK Proteins
* Caffeic Acids
* Cell Line
* Circadian Clocks
* Circadian Rhythm
* Fibroblasts
* Humans
* NF-E2-Related Factor 2
* Polyphenols
* Quercetin
* Receptors, Glucocorticoid
* Resveratrol
* Sirtuin 1
|keywords=* Caffeic acid
* Circadian clock genes
* NR1D1
* NRF2
* Quercetin
* Resveratrol
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05194-8
}}
==PER2==
 
{{medline-entry
|title=NAD  Controls Circadian Reprogramming through [[PER2]] Nuclear Translocation to Counter Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369735
 
|mesh-terms=* ARNTL Transcription Factors
* Age Factors
* Aging
* Animals
* CLOCK Proteins
* Circadian Clocks
* Circadian Rhythm
* Cytokines
* Female
* HEK293 Cells
* Humans
* Male
* Mice
* Mice, Inbred C57BL
* NAD
* Period Circadian Proteins
* Sirtuin 1
* Sirtuins
|keywords=* NAD(+)
* SIRT1
* aging
* circadian
* clock
* heat shock factor 1
* liver
* nicotinamide mononucleotide
* nicotinamide riboside
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275919
}}
==PEX19==
 
{{medline-entry
|title=A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31854076
 
|mesh-terms=* Amino Acid Transport Systems, Basic
* Cellular Senescence
* DNA Replication
* Flap Endonucleases
* Gene Ontology
* Genetic Techniques
* Genomic Instability
* Membrane Proteins
* Mutagenesis
* Mutation
* Mutation Accumulation
* Mutation Rate
* Nuclear Pore Complex Proteins
* Saccharomyces cerevisiae
* Saccharomyces cerevisiae Proteins
* Single-Strand Specific DNA and RNA Endonucleases
|keywords=* genome stability
* high-throughput screen
* mutagenesis
* mutation rate
* replicative aging
* yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996960
}}
==PEX5==
 
{{medline-entry
|title=Aging lowers [[PEX5]] levels in cortical neurons in male and female mouse brains.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32777345
 
 
|keywords=* Aging brain
* PEX5
* Peroxisomal protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484460
}}
==PFAS==
 
{{medline-entry
|title=Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33007577
 
 
|keywords=* EPIC chip
* Environmental pollutant
* Epigenetic aging
* Epigenetics
* PFAS
* Perfluoroalkyl substance
|full-text-url=https://sci-hub.do/10.1016/j.envint.2020.106148
}}
{{medline-entry
|title=Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521362
 
|mesh-terms=* Alkanesulfonic Acids
* Animals
* Caprylates
* Daphnia
* Fatty Acids
* Fluorocarbons
* Humans
* Lipid Metabolism
* Longevity
* Reproduction
|keywords=* Fatty acid
* Fecundity
* Gene expression
* PFAS toxicity
* Perfluorooctane sulfonate (PFOS)
* Perfluorooctanoic acid (PFOA)
|full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.139682
}}
{{medline-entry
|title=The effect of weathering on per- and polyfluoroalkyl substances ([[PFAS]]s) from durable water repellent (DWR) clothing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32062207
 
|mesh-terms=* Acrylates
* Alcohols
* Clothing
* Environmental Monitoring
* Fluorocarbon Polymers
* Fluorocarbons
* Humidity
* Models, Chemical
* Textiles
* Water
* Water Pollutants, Chemical
* Weather
|keywords=* Aging
* Durable water repellency
* Outdoor clothing
* Per- and polyfluoroalkyl substances
* Textile
* Weathering
|full-text-url=https://sci-hub.do/10.1016/j.chemosphere.2020.126100
}}
==PGC==
 
{{medline-entry
|title=The Aging Stress Response and Its Implication for AMD Pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266495
 
 
|keywords=* AMD
* DNA damage response
* PGC-1α
* SIRT1
* age-related macular degeneration
* aging
* autophagy
* insulin/IGF-1
* mitochondrial quality control
* the aging stress response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700335
}}
{{medline-entry
|title=Constitutive [[PGC]]-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33200398
 
 
|keywords=* Aging
* Hippocampal neurogenesis
* Immunohistochemistry
* PGC-1α
* Transgenic mice
* Voluntary running
|full-text-url=https://sci-hub.do/10.1007/s12035-020-02189-6
}}
{{medline-entry
|title=Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and [[PGC]]1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961822
 
 
|keywords=* AMPK signaling pathway
* PGC-1α signaling pathway
* aging
* autophagy
* gut axis
* inflammation
* insulin resistance
* sarcopenic obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555990
}}
{{medline-entry
|title=Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970613
 
 
|keywords=* aging
* caloric restriction
* ischemia/reperfusion
* kidney injury
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585108
}}
{{medline-entry
|title=Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32748504
 
 
|keywords=* aging
* mitochondrial dynamics
* mitochondrial function
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399374
}}
{{medline-entry
|title=[[PGC]]-1α-mediated regulation of mitochondrial function and physiological implications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32516539
 
 
|keywords=* aging
* exercise metabolism
* insulin resistance
* mitochondrial metabolism
* muscle metabolism
* muscle physiology
* métabolisme mitochondrial
* métabolisme musculaire
* métabolisme à l’effort
* physiologie musculaire
* résistance à l’insuline
* vieillissement
|full-text-url=https://sci-hub.do/10.1139/apnm-2020-0005
}}
{{medline-entry
|title=Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32365535
 
 
|keywords=* Down syndrome
* PGC-1α/PPARGC1A
* aging
* mTOR
* mitochondrial dynamics
* mitochondrial function
* mitochondrial network
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247689
}}
{{medline-entry
|title=Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32372536
 
 
|keywords=* ADP sensitivity
* ROS
* aging
* autophagy
|full-text-url=https://sci-hub.do/10.1096/fj.201903113RR
}}
{{medline-entry
|title=A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ [[PGC]]-1α/ pFOXO3 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32335547
 
 
|keywords=* alcalase
* bioactive peptides
* cardio-protection
* hepato-protection
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202530
}}
{{medline-entry
|title=Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330121
 
 
|keywords=* mitochondria
* nucleoid remodeling
* p16INK4a silence
* p53-p21-PKCζ activation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202532
}}
{{medline-entry
|title=[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115557
 
|mesh-terms=* Adipose Tissue, White
* Aging
* Animals
* Caloric Restriction
* Gene Expression
* Humans
* Longevity
* Mice
* Organelle Biogenesis
* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
* Sirtuin 3
* Sterol Regulatory Element Binding Protein 1
* Up-Regulation
|keywords=* caloric restriction (CR)
* fatty acid biosynthesis
* mitochondria
* white adipose tissue (WAT)
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-2
}}
{{medline-entry
|title=Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068089
 
 
|keywords=* Aging
* Kynurenine aminotransferases
* Mitochondria
* Muscle fiber-type
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110880
}}
{{medline-entry
|title=Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31958774
 
 
|keywords=* mitochondria
* oxidative stress
* pig
* postovulatory aging
* ubiquinol-10
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053629
}}
{{medline-entry
|title=Mitochondrial oxidative capacity and NAD  biosynthesis are reduced in human sarcopenia across ethnicities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31862890
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biopsy
* Case-Control Studies
* Energy Metabolism
* Humans
* Jamaica
* Male
* Middle Aged
* Mitochondria
* Muscle, Skeletal
* NAD
* Oxidation-Reduction
* Oxidative Phosphorylation
* Oxidative Stress
* Proteostasis
* Sarcopenia
* Singapore
* United Kingdom
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925228
}}
{{medline-entry
|title=MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443378
 
 
|keywords=* diabetic retinopathy
* miR-34a
* mitochondrial dysfunction
* vascular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769710
}}
{{medline-entry
|title=Constitutive [[PGC]]-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444397
 
|mesh-terms=* Aging
* Animals
* Blood Proteins
* Cytokines
* Female
* Hippocampus
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Muscle, Skeletal
* Neurogenesis
* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
* Reproducibility of Results
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707251
}}
==PGK2==
 
{{medline-entry
|title=Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31472347
 
|mesh-terms=* Aging
* Animals
* Arsenic
* Cell Cycle Proteins
* DEAD-box RNA Helicases
* Gene Expression Profiling
* Male
* Mice
* RNA, Messenger
* Spermatids
* Spermatogenesis
* Spermatozoa
|keywords=* Arsenic
* Elongation of spermatids
* Male reproduction
* Spermatogenesis
|full-text-url=https://sci-hub.do/10.1016/j.chemosphere.2019.124650
}}
==PGLS==
 
{{medline-entry
|title=547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31779658
 
|mesh-terms=* Aging
* Animals
* Brain
* Carboxylic Ester Hydrolases
* Macaca mulatta
* Male
* Mice
* Transcriptome
|keywords=* Brain aging
* Multiple brain regions
* PGLS
* Rhesus macaques
* Transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883628
}}
==PIEZO1==
 
{{medline-entry
|title=Niche stiffness underlies the ageing of central nervous system progenitor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413369
 
|mesh-terms=* Adult Stem Cells
* Aging
* Animals
* Animals, Newborn
* Cell Count
* Central Nervous System
* Extracellular Matrix
* Female
* Humans
* Membrane Proteins
* Multipotent Stem Cells
* Oligodendroglia
* Rats
* Stem Cell Niche
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025879
}}
==PINK1==
 
{{medline-entry
|title=Spermidine inhibits neurodegeneration and delays aging via the [[PINK1]]-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32902411
 
 
|keywords=* aging
* caenorhabditis elegans
* mitophagy
* neurodegenerative diseases
* spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521492
}}
{{medline-entry
|title=Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846275
 
 
|keywords=* Aging
* Dopamine
* Electrophysiology
* Firing
* Mouse
* Substantia nigra
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606778
}}
{{medline-entry
|title=Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32749068
 
 
|keywords=*
Drosophila
 
* MAPK-ERK-ETS signaling
* Parkinson's disease
* SMARCA4/Brahma
* aging
* neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511865
}}
{{medline-entry
|title=SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via [[PINK1]]-dependent mitophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687063
 
 
|keywords=* SIRT1
* compression
* mitophagy
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485741
}}
{{medline-entry
|title=Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386191
 
 
|keywords=* Drosophila melanogaster
* Levodopa induced dyskinesia
* PINK1B9
 
* Parkinsonism
* Parkinson’s disease
* aging
* antioxidant activity
* catalase
* climbing index
* lifespan
* oxidative stress
* propolis
|full-text-url=https://sci-hub.do/10.1515/jcim-2019-0136
}}
{{medline-entry
|title=Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the [[PINK1]]/PARKIN pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281308
 
 
|keywords=* PARKIN pathway
* PINK1
* compression
* intervertebral disc
* mitophagy
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214186
}}
{{medline-entry
|title=Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32100342
 
|mesh-terms=* Autophagy
* Breast Neoplasms
* Cell Culture Techniques
* Cell Line, Tumor
* Doxorubicin
* Drugs, Chinese Herbal
* Female
* Ginsenosides
* Humans
* Mitochondria
* Oxidative Stress
|keywords=* ROS
* cancer growth
* cellular senescence
* chemotherapy
* ginsenoside Rh2
* mitophagy
|full-text-url=https://sci-hub.do/10.1002/ptr.6636
}}
{{medline-entry
|title=Mitochondrial DNA heteroplasmy rises in substantial nigra of aged [[PINK1]] KO mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727366
 
|mesh-terms=* Aging
* Animals
* Brain
* DNA Copy Number Variations
* DNA, Mitochondrial
* Gene Frequency
* Mice, Knockout
* Mutation Rate
* Protein Kinases
* Substantia Nigra
|keywords=* PINK1
* Parkin
* Parkinson’s disease
* mtDNA heteroplasmy
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.112
}}
==PIP==
 
{{medline-entry
|title=Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785232
 
|mesh-terms=* Aged
* Cross-Sectional Studies
* Female
* Geriatrics
* Humans
* Inappropriate Prescribing
* Independent Living
* Male
* Multimorbidity
* Polypharmacy
* Potentially Inappropriate Medication List
* Prevalence
* Primary Health Care
* Risk
* Spain
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423095
}}
{{medline-entry
|title=Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31856733
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Drug Prescriptions
* Female
* Follow-Up Studies
* Forecasting
* Hospitalization
* Humans
* Inappropriate Prescribing
* Longitudinal Studies
* Male
* New Zealand
* Patient Discharge
* Potentially Inappropriate Medication List
|keywords=* Appropriate prescribing
* Ethnicity
* Longitudinal study
* Older people
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921419
}}
==PLIN2==
 
{{medline-entry
|title=Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31661297
 
|mesh-terms=* Animals
* Atrial Fibrillation
* Connexin 43
* Gene Knock-In Techniques
* Heart Atria
* Isolated Heart Preparation
* Lipid Droplets
* Mice
* Mice, Transgenic
* Microscopy, Electron
* Myocytes, Cardiac
* Perilipin-2
* Sterol Esterase
* Triglycerides
* Voltage-Sensitive Dye Imaging
|keywords=* aging
* cardiac steatosis
* gap junction
* lipid droplets
* lipotoxic arrhythmia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957375
}}
==PLK4==
 
{{medline-entry
|title=A novel lncRNA [[PLK4]] up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243714
 
 
|keywords=* Yes-associated protein
* cellular senescence
* hepatocellular carcinoma
* polo-like kinase 4 associated lncRNA
* talazoparib
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205816
}}
{{medline-entry
|title=Differential expression of AURKA/[[PLK4]] in quiescence and senescence of osteosarcoma U2OS cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200684
 
 
|keywords=* AURKA
* Osteosarcoma
* PLK4
* quiescence
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217361
}}
==PLN==
 
{{medline-entry
|title=An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399116
 
 
|keywords=* Polish health care system
* ageing society
* gerontology
* healthcare
* hospital costs
* length and cost of hospitalization
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212232
}}
==PML==
 
{{medline-entry
|title=Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32808554
 
 
|keywords=* Multiple sclerosis
* PML
* fumarate
* immunosenescence
* lymphopenia
|full-text-url=https://sci-hub.do/10.1177/1352458520949158
}}
{{medline-entry
|title=[[PML]]2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32351002
 
 
|keywords=* HGPS
* PML2
* senescence
* thread-like PML NBs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294779
}}
==PNN==
 
{{medline-entry
|title=Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33253804
 
 
|keywords=* Brain aging
* Chondroitin sulfate proteoglycan
* Extracellular matrix
* Hyaluronan
* Perineuronal net
|full-text-url=https://sci-hub.do/10.1016/j.bbagen.2020.129804
}}
==PNP==
 
{{medline-entry
|title=Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31803012
 
 
|keywords=* TDMT
* aging
* kinesthesia
* pointing task
* position estimation
* somatosensory temporal discrimination
* temporal discrimination threshold
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877661
}}
==POLL==
 
{{medline-entry
|title=Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32062407
 
|mesh-terms=* Aged
* Aged, 80 and over
* Australia
* Cancer Survivors
* Cohort Studies
* Female
* Humans
* Life Expectancy
* Male
* Middle Aged
* Neoplasms
|keywords=* Australia
* Cancer
* Life expectancy
* Survival
* Temporal
|full-text-url=https://sci-hub.do/10.1016/j.canep.2020.101686
}}
==POLR3A==
 
{{medline-entry
|title=Nucleolar disruption, activation of P53 and premature senescence in [[POLR3A]]-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32976914
 
 
|keywords=* Cell senescence
* DNA damage
* Nucleolus
* Nucleus
* RNA polymerase III subunit A (POLR3A)
* Wiedemann-Rautenstrauch syndrome
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111360
}}
==POMC==
 
{{medline-entry
|title=Gpr17 deficiency in [[POMC]] neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31611548
 
|mesh-terms=* Aging
* Animals
* Body Weight
* Brain
* Diet, High-Fat
* Energy Metabolism
* Female
* Homeostasis
* Insulin Resistance
* Liver
* Male
* Mice
* Mice, Knockout
* Motor Activity
* Nerve Tissue Proteins
* Neurons
* Pro-Opiomelanocortin
* Receptors, G-Protein-Coupled
* Sex Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791877
}}
==POR==
 
{{medline-entry
|title=The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749695
 
 
|keywords=* Evans’ index
* aging
* brain
* enlargement
* hydrocephalus
* normal pressure
* ventricular system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848156
}}
==POT1==
 
{{medline-entry
|title=MiR-185 targets [[POT1]] to induce telomere dysfunction and cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687062
 
 
|keywords=* aging
* cellular senescence
* miR-185
* protection of telomere 1
* telomere dysfunction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425516
}}
{{medline-entry
|title=Seryl tRNA synthetase cooperates with [[POT1]] to regulate telomere length and cellular senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815007
 
 
|keywords=* Cancer genomics
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882858
}}
==POU5F1==
 
{{medline-entry
|title=Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148459
 
 
|keywords=* ALDH family
* Adipose stem cells
* Aging
* Shelterin complex
* Spheroid
* Telomere length
|full-text-url=https://sci-hub.do/10.1016/j.gene.2020.145269
}}
==PPID==
 
{{medline-entry
|title=Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058159
 
|mesh-terms=* Aging
* Animals
* Body Composition
* Cytokines
* Female
* Folic Acid
* Horse Diseases
* Horses
* Inflammation
* Male
* Nutrients
* Pituitary Diseases
* Pituitary Gland, Intermediate
|keywords=* Horse
* Inflamm-aging
* Muscle
* Nutrition
* Pituitary pars intermedia dysfunction
* Senior
|full-text-url=https://sci-hub.do/10.1016/j.vetimm.2020.110013
}}
==PRDM8==
 
{{medline-entry
|title=[[PRDM8]] reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32819411
 
 
|keywords=* Aging
* Aplastic anemia
* DNA methylation
* Dyskeratosis congenita
* Epigenetic clock
* Hematopoietic differentiation
* Neuronal differentiation
* PRDM8
* Telomere
* iPSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439574
}}
==PRDX1==
 
{{medline-entry
|title=Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31756344
 
|mesh-terms=* Animals
* Apoptosis
* Cellular Senescence
* Diet, High-Fat
* Dietary Supplements
* Fas Ligand Protein
* Hepatocytes
* Metabolic Networks and Pathways
* Mice, Knockout
* Non-alcoholic Fatty Liver Disease
* Oxidative Stress
* Proteins
* Steroid Hydroxylases
* Tumor Suppressor Protein p53
* Vitamin D
* fas Receptor
|keywords=* Active vitamin D
* Apoptosis
* Nonalcoholic fatty liver disease
* Oxidative stress
* Senescence
* p53 pathway
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117086
}}
==PRDX3==
 
{{medline-entry
|title=Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32148389
 
 
|keywords=* Ginsenoside Rg3(S)
* Human dermal fibroblast
* Label-free quantitative proteomics
* Restoration
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033328
}}
==PRDX6==
 
{{medline-entry
|title=Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417400
 
 
|keywords=* PRDX6
* aging
* dentate gyrus
* hippocampus
* hole-board
* peroxiredoxin
* proteomics
* spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684764
}}
==PRKDC==
 
{{medline-entry
|title=DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31464599
 
|mesh-terms=* Animals
* Cell Line
* Cell Proliferation
* Cellular Senescence
* Chromones
* DNA Damage
* DNA Repair
* DNA-Activated Protein Kinase
* DNA-Binding Proteins
* Female
* Fibroblasts
* Humans
* Idiopathic Pulmonary Fibrosis
* Lung
* Mesenchymal Stem Cells
* Mice
* Mice, SCID
* Morpholines
|keywords=* DNA-PKcs
* IPF
* Mesenchymal progenitor cells
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716822
}}
==PRL==
 
{{medline-entry
|title=Mechanism of [[PRL]]2 phosphatase-mediated PTEN degradation and tumorigenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32788364
 
|mesh-terms=* Animals
* Carcinogenesis
* Female
* HEK293 Cells
* Humans
* Immediate-Early Proteins
* Longevity
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Nedd4 Ubiquitin Protein Ligases
* PTEN Phosphohydrolase
* Protein Tyrosine Phosphatases
* Proto-Oncogene Proteins c-akt
* Ubiquitination
|keywords=* NEDD4
* PRL2
* PTEN
* protein tyrosine phosphatases
* ubiquitination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456095
}}
{{medline-entry
|title=Prolactin mitigates deficiencies of retinal function associated with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698287
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Electroretinography
* Mice, Inbred C57BL
* Nerve Growth Factors
* Neuroglia
* Prolactin
* Retina
* Retinal Degeneration
|keywords=* Aging
* Apoptosis
* Glia activation
* Hormone
* Mesotopic and photopic electroretinogram
* Retina
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.10.002
}}
{{medline-entry
|title=A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31390566
 
|mesh-terms=* Aging
* Animals
* Carcinogenesis
* Datasets as Topic
* Estrogen Receptor alpha
* Female
* Gene Expression Profiling
* Humans
* Mammary Neoplasms, Experimental
* Mice
* Prolactin
* Proto-Oncogene Proteins p21(ras)
* Rats
* Signal Transduction
* Transgenes
|keywords=* ER+ breast cancer
* Ras mutations
* breast cancer
* genomic analyses
* mouse models
* prolactin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713291
}}
==PRNP==
 
{{medline-entry
|title=Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32516343
 
|mesh-terms=* Adult
* Aging
* Amyloid
* Animals
* Brain
* Codon
* Heterozygote
* Homozygote
* Humans
* Mice, Transgenic
* Middle Aged
* Prions
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282622
}}
==PROC==
 
{{medline-entry
|title=Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31633180
 
 
|keywords=* actigraphy
* aging
* sleep duration
* sleep in women
* sleep quality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157190
}}
==PSD==
 
{{medline-entry
|title=Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652177
 
 
|keywords=* aging
* brain
* cortex
* glutamate receptor
* synapse
* vesicle
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2020.06.044
}}
{{medline-entry
|title=Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32390823
 
 
|keywords=* DKK-1
* Wnt
* brain aging
* exercise
* β-catenin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192222
}}
{{medline-entry
|title=Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31938742
 
 
|keywords=* Aging
* Mitochondrial function
* Neuroscience
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953639
}}
==PSEN2==
 
{{medline-entry
|title=Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human [[PSEN2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978074
 
|mesh-terms=* Aging
* Alternative Splicing
* Alzheimer Disease
* Animals
* Animals, Genetically Modified
* Brain
* Datasets as Topic
* Disease Models, Animal
* Down-Regulation
* Female
* Frameshift Mutation
* Gene Editing
* Gene Regulatory Networks
* Heterozygote
* Humans
* Microglia
* Presenilin-1
* Presenilin-2
* Protein Isoforms
* Proteomics
* RNA-Seq
* Up-Regulation
* Zebrafish
* Zebrafish Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980398
}}
{{medline-entry
|title=Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31862541
 
 
|keywords=* Aging
* Alzheimer's
* Carbamazepine
* Corneal kindling
* Diazepam
* Epilepsy
* Lamotrigine
* Levetiracetam
* Presenilin
* Seizures
* Valproic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462087
}}
==PSMD11==
 
{{medline-entry
|title=The effect and mechanism of 19S proteasome [[PSMD11]]/Rpn6 subunit in D-Galactose induced mimetic aging models.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32450067
 
 
|keywords=* Age-related hearing loss
* Aging
* D-galactose
* PSMD11
* Proteasome
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112093
}}
==PSMD14==
 
{{medline-entry
|title=Upregulation of deubiquitinase [[PSMD14]] in lung adenocarcinoma (LUAD) and its prognostic significance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32226511
 
 
|keywords=* PMSD14
* apoptosis
* deubiquitinating enzyme
* lung adenocarcinoma
* prognosis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086243
}}
==PTEN==
 
{{medline-entry
|title=Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33186519
 
 
|keywords=* FGF1
* GDF-15
* MMPs
* PTEN
* TIMP1
* docetaxel
* prostate cancer metastasis
* senescence
* senescence-associated secretory phenotype (SASP)
* senolytic therapy
|full-text-url=https://sci-hub.do/10.1016/j.ccell.2020.10.012
}}
{{medline-entry
|title=Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33023448
 
 
|keywords=* Alzheimer's disease
* DRP1
* FIS1
* aging
* mitochondrial dynamics
* mitophagy
|full-text-url=https://sci-hub.do/10.2174/1567205017666201006162538
}}
{{medline-entry
|title=Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32944188
 
 
|keywords=* Extracellular vesicle
* bone loss
* bone marrow MSCs
* cellular senescence
* embryonic stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480439
}}
{{medline-entry
|title=The precursor of PI(3,4,5)P  alleviates aging by activating daf-18(Pten) and independent of daf-16.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32901024
 
|mesh-terms=* Aging
* Animals
* Animals, Genetically Modified
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Cell Line, Tumor
* Female
* Forkhead Transcription Factors
* Inositol
* Locomotion
* Longevity
* Metabolic Networks and Pathways
* Metabolomics
* Mice
* Mitophagy
* Models, Animal
* PTEN Phosphohydrolase
* Phosphatidylinositol Phosphates
* Protein Kinases
* Protein-Serine-Threonine Kinases
* RNA Interference
* RNA-Seq
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479145
}}
{{medline-entry
|title=Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32702447
 
|mesh-terms=* Animals
* Antioxidants
* Cell Line
* Cellular Senescence
* Epithelium
* Fibrosis
* Flow Cytometry
* Kidney
* Kidney Tubules, Proximal
* Mitophagy
* Protein Kinases
* Quercetin
* Rats
* Sirtuin 1
|keywords=* Fibrosis
* Mitochondria
* Mitophagy
* Quercetin
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118116
}}
{{medline-entry
|title=Downregulation of [[PTEN]] mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436415
 
 
|keywords=* PI3K/Akt/mTOR pathway
* PTEN
* autophagy
* bleomycin
* cancer cell
* premature senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287201
}}
{{medline-entry
|title=miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948758
 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* Cell Line
* Cells, Cultured
* Down-Regulation
* Humans
* Male
* Mesenchymal Stem Cells
* Mice, Inbred C57BL
* MicroRNAs
* Mitophagy
* Protein Interaction Maps
* Protein Kinases
* Up-Regulation
|keywords=* Aging
* Bone marrow MSCs
* Mitophagy
* miR-155
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.01.022
}}
{{medline-entry
|title=Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849968
 
|mesh-terms=* Airway Remodeling
* Asthma
* Autophagy
* Cellular Senescence
* Disease Susceptibility
* Environmental Exposure
* Humans
* Mitophagy
* Oxidative Stress
* Respiratory Mucosa
|keywords=* asthma
* autophagy
* mitophagy
* oxidative stress
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896909
}}
{{medline-entry
|title=[[PTEN]] loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31527305
 
|mesh-terms=* Aging
* Cellular Senescence
* Epithelial Cells
* Humans
* Idiopathic Pulmonary Fibrosis
* PTEN Phosphohydrolase
* Proto-Oncogene Proteins c-akt
* Pulmonary Alveoli
* Respiratory Mucosa
|keywords=* aging
* cellular senescence
* phosphatase and tension homolog deleted on chromosome ten
* protein kinase B
* pulmonary fibrosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781970
}}
==PTH==
 
{{medline-entry
|title=Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32899460
 
 
|keywords=* aging
* frailty
* vitamin D
* vitamin D receptor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551757
}}
{{medline-entry
|title=Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154622
 
|mesh-terms=* Aging
* Animals
* Calcium-Regulating Hormones and Agents
* Cells, Cultured
* Disease Models, Animal
* Male
* Mice
* Mice, Inbred C57BL
* Osteoarthritis
* Osteogenesis
* Parathyroid Hormone
* Temporomandibular Joint
|keywords=* cellular senescence
* cyclin-dependent kinase inhibitor P16INK4A
* marrow mesenchymal stem cells
* osteoarthritis
* temporomandibular joint disorders
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162802
}}
==PTP4A3==
 
{{medline-entry
|title=Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32402127
 
 
|keywords=* 3D microvascular network
* blood-brain barrier
* endothelium
* human serum
* vascular aging
|full-text-url=https://sci-hub.do/10.1002/adbi.202000044
}}
==PTPN11==
 
{{medline-entry
|title=Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32888012
 
 
|keywords=*
          SowPro90
       
* Bayes interval mapping
* custom genotyping array
* gilts
* puberty
* reproductive longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568434
}}
==PTTG1==
 
{{medline-entry
|title=[Down-regulated [[PTTG1]] expression promotes the senescence of human prostate cancer LNCaP-AI].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32216239
 
|mesh-terms=* Cell Line, Tumor
* Cell Proliferation
* Humans
* Male
* Prostatic Neoplasms, Castration-Resistant
* RNA, Small Interfering
* Securin
* beta-Galactosidase
|keywords=*  LNCaP-AI cell
 
*  castration-resistant prostate cancer
*  cellular senescence
*  pituitary tumor-transforming gene-1
* prostate cancer
 
}}
==PTX3==
 
{{medline-entry
|title=Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012711
 
 
|keywords=* aging
* endurance training
* exercise
* inflammation
* oxidative stress
* pentraxin 3
* toll-like receptor 4
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070734
}}
{{medline-entry
|title=Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31808814
 
 
|keywords=* Biomarkers
* Cognitive aging
* Inflammation
* Sex differences
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357589
}}
==PUM1==
 
{{medline-entry
|title=Identification of reference genes for RT-qPCR data normalisation in aging studies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562345
 
|mesh-terms=* Aging
* Algorithms
* Gene Expression Profiling
* Genes, Essential
* Humans
* Real-Time Polymerase Chain Reaction
* Software
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764958
}}
==RACK1==
 
{{medline-entry
|title=Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636180
 
|mesh-terms=* Aging
* Animals
* Brain
* Female
* Gene Expression Regulation, Developmental
* Male
* Mice
* Proteomics
* Ribosomal Proteins
|keywords=* aging
* mass spectrometry
* neuronal tissues
* ribosome
* translation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842600
}}
==RAF1==
 
{{medline-entry
|title=Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during [[RAF1]] oncogene-induced senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862732
 
 
|keywords=*  INK4 locus
* Non-coding RNAs
* Polycomb proteins
* circular RNAs
* gene expression regulation
* oncogene-induced senescence
|full-text-url=https://sci-hub.do/10.1080/15476286.2020.1812910
}}
==RAG1==
 
{{medline-entry
|title=T cell senescence accelerates Angiotensin II-induced target organ damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32049355
 
 
|keywords=* T cell
* angiotensin II
* cardiorenal dysfunction
* senescence
|full-text-url=https://sci-hub.do/10.1093/cvr/cvaa032
}}
==RAG2==
 
{{medline-entry
|title=Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793218
 
 
|keywords=* aging
* glucose transporters
* human
* metabolism
* mice
* phosphate transporters
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387685
}}
==RAN==
 
{{medline-entry
|title=Rapid automatized naming ([[RAN]]): effects of aging on a predictor of reading skill.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799742
 
 
|keywords=* Aging
* RAN
* individual differences
* naming
* reading
|full-text-url=https://sci-hub.do/10.1080/13825585.2020.1806987
}}
==RELB==
 
{{medline-entry
|title=New control of the senescence barrier in breast cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158912
 
 
|keywords=* CEBPB
* Cellular senescence
* PAK4
* RELB
* p21-activated kinase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051141
}}
==REST==
 
{{medline-entry
|title=[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115559
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Animals
* Brain
* Gene Expression
* Gene Expression Regulation, Developmental
* Humans
* Neurodegenerative Diseases
* Protein Biosynthesis
* Repressor Proteins
* Ribosomes
|keywords=* aging
* brain
* gene expression
* neurodegeneration
* ribosome
* translational fidelity
|full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-4
}}
{{medline-entry
|title=Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32014256
 
|mesh-terms=* Aging
* Animals
* Behavior, Animal
* Blood Glucose
* Body Weight
* Brain
* Brain-Derived Neurotrophic Factor
* Cognitive Dysfunction
* Diabetes Mellitus, Experimental
* Exploratory Behavior
* Male
* Memory Disorders
* Mice
* Palmitic Acid
* Repressor Proteins
* Social Behavior
* Spatial Memory
* Stearic Acids
|keywords=* 9-PAHSA
* BDNF
* Diabetes mellitus
* REST
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.01.071
}}
{{medline-entry
|title=Increased [[REST]] to Optimize Life Span?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31762373
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Homeostasis
* Longevity
* Repressor Proteins
* Signal Transduction
|keywords=* life span
* neuronal activity
* neurotoxicity
|full-text-url=https://sci-hub.do/10.1089/rej.2019.2287
}}
==RET==
 
{{medline-entry
|title=Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32615210
 
 
|keywords=* Aging
* Antioxidants
* Exercise
* Oxidative stress
* Resistance exercise training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111012
}}
{{medline-entry
|title=Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32562747
 
 
|keywords=* Aging
* Muscle echo intensity
* Muscle quality
* Physical function
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111003
}}
{{medline-entry
|title=Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32134710
 
 
|keywords=* aging
* hypertrophy
* myonuclear domain
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191507
}}
{{medline-entry
|title=Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518665
 
|mesh-terms=* Adaptation, Physiological
* Aged
* Capillaries
* Citrate (si)-Synthase
* Exercise
* Female
* Humans
* Hypertrophy
* Male
* Muscle Fibers, Skeletal
* Muscle Proteins
* Muscle, Skeletal
* Resistance Training
* Sarcopenia
* Ubiquitin-Protein Ligases
|keywords=* Aging
* Capillary
* Fiber cross-sectional area
* Muscle hypertrophy
* Muscle protein synthesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904952
}}
==REV1==
 
{{medline-entry
|title=[[REV1]] inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168727
 
 
|keywords=* Rev1
* cell death
* chemotherapy
* senescence
* translesion synthesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682577
}}
==RHEB==
 
{{medline-entry
|title=The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041790
 
|mesh-terms=* Animals
* Animals, Genetically Modified
* Autophagy
* CRISPR-Cas Systems
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Life Cycle Stages
* Longevity
* Mechanistic Target of Rapamycin Complex 1
* Phosphotransferases (Alcohol Group Acceptor)
* RNA Interference
* RNA, Small Interfering
* Ras Homolog Enriched in Brain Protein
* Signal Transduction
|keywords=* MTOR
* MTORC1
* Ral
* RalGAP
* TSC
* Tuberous sclerosis complex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063671
}}
==RHO==
 
{{medline-entry
|title=Conditional reprogramming: next generation cell culture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32963937
 
 
|keywords=* 3T3-J2 fibroblast
* AACR, American Association for Cancer Research
* ACC, adenoid cystic carcinoma
* AR, androgen receptor
* CFTR, cystic fibrosis transmembrane conductance regulators
* CR, conditional reprogramming
* CYPs, cytochrome P450 enzymes
* Conditional reprogramming
* DCIS, ductal carcinoma in situ
* ECM, extracellular matrix
* ESC, embryonic stem cell
* HCMI, human cancer model initiatives
* HGF, hepatocyte growth factor
* HNE, human nasal epithelial
* HPV, human papillomaviruses
* ICD, intracellular domain
* LECs, limbal epithelial cells
* NCI, National Cancer Institute
* NGFR, nerve growth factor receptor
* NSCLC, non-small cell lung cancer
* NSG, NOD/SCID/gamma
* PDAC, pancreatic ductal adenocarcinoma
* PDX, patient derived xenograft
* PP2A, protein phosphatase 2A
* RB, retinoblastoma-associated protein
* ROCK
* ROCK, Rho kinase
* SV40, simian virus 40 large tumor antigen
* Senescence
* UVB, ultraviolet radiation b
* Y-27632
* dECM, decellularized extracellular matrix
* hASC, human adipose stem cells
* hTERT, human telomerase reverse transcriptase
* iPSCs, induction of pluripotent stem cells
* ΔNP63α, N-terminal truncated form of P63α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488362
}}
{{medline-entry
|title=SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246845
 
|mesh-terms=* Adult
* Aging
* Angiotensin-Converting Enzyme 2
* Bronchi
* COVID-19
* Cells, Cultured
* Chronic Disease
* Coronavirus Infections
* Epithelial Cells
* Female
* Gene Expression
* Gene Expression Profiling
* Germany
* Goblet Cells
* Humans
* Lung
* Male
* Middle Aged
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* Reference Standards
* Sequence Analysis, RNA
* Serine Endopeptidases
* Sex Characteristics
* Single-Cell Analysis
* Smoking
* Tissue Banks
|keywords=*
FURIN
 
* COVID-19
* Human Cell Atlas
* epithelial differentiation
* respiratory tract
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232010
}}
==RICTOR==
 
{{medline-entry
|title=Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31476350
 
|mesh-terms=* Cellular Senescence
* Endothelial Cells
* Human Umbilical Vein Endothelial Cells
* Humans
* MicroRNAs
* Nerve Tissue Proteins
* Phosphorylation
* Protein Binding
* Rapamycin-Insensitive Companion of mTOR Protein
* Ribonucleoproteins
* Telomeric Repeat Binding Protein 2
* Ubiquitin-Protein Ligases
|keywords=* Inflammation
* MKRN1
* Senescence
* Senescence-associated secretory phenotype (SASP)
* Telomeric repeat binding factor 2-interacting protein (TERF2IP)
* p90RSK
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059097
}}
==RIF1==
 
{{medline-entry
|title=53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31653568
 
|mesh-terms=* Aging
* Animals
* BRCA1 Protein
* DNA Breaks, Double-Stranded
* DNA Damage
* Genomic Instability
* Homologous Recombination
* Mice
* Mutation
* Poly(ADP-ribose) Polymerase Inhibitors
* Rad51 Recombinase
* Tumor Suppressor p53-Binding Protein 1
* Ubiquitin-Protein Ligases
|keywords=* 53BP1
* BRCA1
* PARPi
* aging
* cancer
* homologous recombination
* resection
* shieldin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993210
}}
==RIPK1==
 
{{medline-entry
|title=Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33206046
 
 
|keywords=* aging
* cell biology
* mouse
* necroptosis
* protein kinase
* reproductivity
* testis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673785
}}
{{medline-entry
|title=Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31981738
 
 
|keywords=* Aurintricarboxylic acid
* Cartilage trauma
* Hypertrophy
* Regulated cell death
* Senescence
* Terminal complement complex
|full-text-url=https://sci-hub.do/10.1016/j.joca.2020.01.004
}}
==RIPK3==
 
{{medline-entry
|title=Metformin mediates cardioprotection against aging-induced ischemic necroptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31944526
 
|mesh-terms=* Aging
* Animals
* Autophagy
* GTPase-Activating Proteins
* Humans
* Hypoglycemic Agents
* Imidazoles
* Indoles
* Male
* Metformin
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Myocardium
* Myocytes, Cardiac
* Necroptosis
* Protein Binding
* RNA, Small Interfering
* Receptor-Interacting Protein Serine-Threonine Kinases
* Reperfusion Injury
* Sequestosome-1 Protein
|keywords=* aging
* autophagy defect
* cardioprotection
* ischemia/reperfusion injury
* metformin
* myocardial necroptosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996959
}}
==RNF10==
 
{{medline-entry
|title=Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33249776
 
 
|keywords=* E3 ubiquitin ligase
* RNF10
* immunosenescence
* inflammation
* macrophages
|full-text-url=https://sci-hub.do/10.1002/2211-5463.13049
}}
==RNF13==
 
{{medline-entry
|title=The effects of environmental stressors on candidate aging associated genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32344118
 
 
|keywords=* Aging
* Candidate genes
* Environmental factors
* Epigenetic
* Hypo/hyper methylated (methylation)
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110952
}}
==ROCK2==
 
{{medline-entry
|title=Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032622
 
 
|keywords=* Aging
* Insulin resistance
* Physical exercise
* Rho-kinase (ROCK)
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111213
}}
==RPE==
 
{{medline-entry
|title=Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307245
 
 
|keywords=* Aging
* Human embryonic stem cell
* Human pluripotent stem cell
* Retinal pigment epithelium
* Single-cell RNA sequencing
|full-text-url=https://sci-hub.do/10.1016/j.gpb.2020.08.002
}}
{{medline-entry
|title=Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187067
 
 
|keywords=* aging
* cardiorespiratory
* maximum test
* rate of perceived exertion
* water aerobics
* water-based exercises
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697777
}}
{{medline-entry
|title=Photoreceptor Degeneration in Homozygous Male Per2  Mice During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135952
 
 
|keywords=* Per2luc
* aging
* circadian
* mice
* photoreceptors
* retinal pigment epithelium
|full-text-url=https://sci-hub.do/10.1177/0748730420965285
}}
{{medline-entry
|title=An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into [[RPE]] Stress Associated with Retinopathy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932802
 
 
|keywords=* AMD
* RPE
* aging
* autofluorescence
* autophagy
* diet
* lysosomes
* oxidized POS
* proteolysis
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555953
}}
{{medline-entry
|title=Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904579
 
 
|keywords=* aging
* exercise
* hypertension
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457386
}}
{{medline-entry
|title=Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32881874
 
|mesh-terms=* Aged
* Aging
* Brain
* Female
* Humans
* Linear Models
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Multivariate Analysis
* Neurodegenerative Diseases
* Organ Size
* Retinal Photoreceptor Cell Outer Segment
* Retinal Pigment Epithelium
* Tomography, Optical Coherence
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470418
}}
{{medline-entry
|title=Oxidative stress in the retina and retinal pigment epithelium ([[RPE]]): Role of aging, and DJ-1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32826201
 
 
|keywords=* Aging
* DJ-1
* Oxidative stress
* Retina
* Retinal pigment epithelium
* Sodium iodate
|full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101623
}}
{{medline-entry
|title=Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744516
 
|mesh-terms=* Aging
* Animals
* Electrophysiological Phenomena
* Electroretinography
* Light
* Mice
* Retinal Pigment Epithelium
 
|full-text-url=https://sci-hub.do/10.3791/61491
}}
{{medline-entry
|title=High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737203
 
 
|keywords=* age-related macular degeneration
* aging
* apolipoprotein
* complement
* complement factor H
* glycosaminoglycan
* heparan sulfate
* heparan sulfate proteoglycans
* high-density lipoprotein (HDL)
* lipoprotein
* oligosaccharide
* retinal degeneration
* retinal pigmented epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521644
}}
{{medline-entry
|title=MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721041
 
 
|keywords=* AMD
* Mtor
* aging
* lipid
* metabolism
|full-text-url=https://sci-hub.do/10.1096/fj.202000612R
}}
{{medline-entry
|title=[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708511
 
 
|keywords=* cellular senescence
* eye fatigue
* inflammation
* lactic acid bacteria
* probiotics
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403967
}}
{{medline-entry
|title=Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634473
 
 
|keywords=* Age-related macular degeneration
* Aging
* Differentiation
* Innate immunity
* RNA sequencing
* Smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434665
}}
{{medline-entry
|title=Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442431
 
|mesh-terms=* Adult
* Aging
* Cell Movement
* Female
* Follow-Up Studies
* Humans
* Male
* Ophthalmoscopy
* Retinal Dystrophies
* Retinal Pigment Epithelium
* Retrospective Studies
* Slit Lamp Microscopy
* Tomography, Optical Coherence
 
|full-text-url=https://sci-hub.do/10.1016/j.ajo.2020.05.010
}}
{{medline-entry
|title=Exosomal MiRNA Transfer between Retinal Microglia and [[RPE]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429541
 
 
|keywords=* RPE
* aging
* exosome
* inflammation
* microglia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279010
}}
{{medline-entry
|title=Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429847
 
 
|keywords=* Age-related macular degeneration
* Aging
* Cones
* Dark adaptation
* Light sensitivity
* Macula
* Quantitative autofluorescence
* Retina
* Rods
* Spectral domain optical coherence tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236516
}}
{{medline-entry
|title=Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32298788
 
 
|keywords=* Age-related macular degeneration
* Aggregation
* Aging
* Autophagy
* Clearance
* Degeneration
* Mitochondria
* Mitophagy
* Retina
* Retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650008
}}
{{medline-entry
|title=CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and [[RPE]] disorganization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234210
 
 
|keywords=* RPE disorganization
* aging
* choroid
* choroidal macrophage
* choroidal vasculature
* immunology
* inflammation
* mouse
* neuroscience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156269
}}
{{medline-entry
|title=Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173468
 
 
|keywords=* Extracellular vesicles
* Oxidative stress
* Phagocytosis
* RPE cell Dysfunction
* RPE cell-Derived microparticles (RMPs)
* Retinal pigment epithelial cell (RPE)
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111957
}}
{{medline-entry
|title=Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145293
 
 
|keywords=* Aerobic capacity
* Aerobic training
* Aging
* Aquatic exercise
* Interval exercise
* Muscle echo intensity
* Muscle strength
* Muscle thickness
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110914
}}
{{medline-entry
|title=Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038382
 
 
|keywords=* aging
* recollection and familiarity
* retrieval practice
* temporal dynamics
* testing effect
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990689
}}
{{medline-entry
|title=A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000141
 
|mesh-terms=* Adult
* Aging
* Bicycling
* Heart Rate
* High-Intensity Interval Training
* Humans
* Middle Aged
* Perception
* Physical Exertion
|keywords=* age
* endurance training
* high-intensity interval training
* older athlete
|full-text-url=https://sci-hub.do/10.1123/ijspp.2019-0413
}}
{{medline-entry
|title=Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884616
 
|mesh-terms=* Animals
* Circadian Rhythm
* Epithelial Cells
* Eye Proteins
* Humans
* Mice
* Phagocytosis
* Photoreceptor Cells, Vertebrate
* RNA Splicing Factors
* Retinal Pigment Epithelium
* Retinitis Pigmentosa
|keywords=* Aging
* Cellular stress
* Circadian rhythm
* Metabolism
* PRPF
* Phagocytosis
* Retinal pigment epithelium
* Retinitis pigmentosa
* Splicing factors
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_37
}}
{{medline-entry
|title=AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884657
 
|mesh-terms=* AMP-Activated Protein Kinases
* Animals
* DNA Damage
* DNA, Mitochondrial
* Disease Models, Animal
* Gene Dosage
* Metformin
* Mice
* Oxidative Stress
* Retina
* Retinal Degeneration
* Retinitis Pigmentosa
|keywords=* AMPK
* Adenosine monophosphate-activated protein kinase
* Aging
* Glycolysis
* Metabolism
* Neuroprotection
* Retina
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_78
}}
{{medline-entry
|title=Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840941
 
 
|keywords=* Bruch's membrane
* age-related macular degeneration
* aging
* induced pluripotent stem cells
* nonenzymatic nitration
* retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031648
}}
{{medline-entry
|title=Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712409
 
|mesh-terms=* Amyloid beta-Peptides
* Animals
* Apoptosis
* Autophagy
* Cells, Cultured
* Docosahexaenoic Acids
* Extracellular Matrix
* Fatty Acids, Omega-3
* Gene Expression Regulation
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Photoreceptor Cells
* Retina
* Retinal Pigment Epithelium
* Young Adult
|keywords=* SASP
* age-related macular degeneration
* p16
* retinal pigment epithelial cells
* senescence gene program
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883841
}}
{{medline-entry
|title=Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699817
 
|mesh-terms=* Aging
* Animals
* Basement Membrane
* Bruch Membrane
* Exocytosis
* Humans
* Lysosomal-Associated Membrane Protein 2
* Lysosomes
* Macular Degeneration
* Mice
* Mice, Knockout
* Phagocytosis
* Retina
* Retinal Pigment Epithelium
|keywords=* LAMP2
* aging
* lysosome
* retinal degeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876195
}}
{{medline-entry
|title=Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31648994
 
|mesh-terms=* Age Factors
* Animals
* Biomarkers
* Choroid
* Disease Models, Animal
* Female
* Fluorescein Angiography
* Fundus Oculi
* Humans
* Lipofuscin
* Macular Degeneration
* Male
* Melanins
* Melanosomes
* Mice
* Mice, Knockout
* Optical Imaging
* Oxidation-Reduction
* Oxidative Stress
* Protein Transport
* Retinal Pigment Epithelium
* Tomography, Optical Coherence
|keywords=* Aging
* Lipofuscin
* Melanin
* Melanolipofuscin
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838394
}}
{{medline-entry
|title=Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544587
 
 
|keywords=* Aging
* computational modeling
* individual differences
* reinforcement learning
* working memory
|full-text-url=https://sci-hub.do/10.1080/13825585.2019.1664389
}}
{{medline-entry
|title=Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31392515
 
|mesh-terms=* Aging
* Angiotensin II
* Animals
* Cells, Cultured
* Electroretinography
* Humans
* Ligands
* Lipopolysaccharides
* Mice, Inbred C57BL
* Mice, Knockout
* Oligopeptides
* Rats
* Reactive Oxygen Species
* Receptors, G-Protein-Coupled
* Retina
|keywords=* Alamandine
* Angiotensin-(1–7)
* Mas-related G protein-coupled receptor D
* Rennin-angiotensin system
* Retina
|full-text-url=https://sci-hub.do/10.1007/s12035-019-01716-4
}}
==RPIA==
 
{{medline-entry
|title=Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31433975
 
|mesh-terms=* Aldose-Ketose Isomerases
* Animals
* Cell Line
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p16
* Gene Knockdown Techniques
* Humans
* Male
* Mechanistic Target of Rapamycin Complex 1
* Mice, SCID
* Nucleotides
* Pentose Phosphate Pathway
* Protein Biosynthesis
|keywords=* BRAF
* cancer metabolism
* cell cycle
* melanoma
* nevi
* pancreatic cancer
* pentose phosphate pathway
* ribonucleotide reductase M2
* ribose-5-phosphate isomerase A
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716532
}}
==RPS19BP1==
 
{{medline-entry
|title=Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659678
 
 
|keywords=* Oxidative stress
* Pinellia ternata
* SIRT1
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153275
}}
==RTEL1==
 
{{medline-entry
|title=Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444995
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Cohort Studies
* Female
* Humans
* Male
* Mendelian Randomization Analysis
* Middle Aged
* Risk Factors
* Telomere Homeostasis
|keywords=* TERT
* UK Biobank
* anti-aging
* cellular senescence
* centenarians
* frailty
* longevity
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826144
}}
==RXFP3==
 
{{medline-entry
|title=The [[RXFP3]] receptor is functionally associated with cellular responses to oxidative stress and DNA damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794429
 
|mesh-terms=* Camptothecin
* Computational Biology
* DNA Damage
* Felodipine
* GTPase-Activating Proteins
* Gene Expression Regulation
* Gene Regulatory Networks
* HEK293 Cells
* Humans
* Oxidative Stress
* RNA, Messenger
* Receptors, G-Protein-Coupled
* Topoisomerase I Inhibitors
|keywords=* DNA damage
* GPCR
* aging
* relaxin 3
* relaxin family peptide 3 receptor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932917
}}
==S100A4==
 
{{medline-entry
|title=Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678243
 
|mesh-terms=* Alarmins
* Animals
* Cytokines
* Exosomes
* Lung
* Mesenchymal Stem Cells
* Mice
* Mitochondria
* Mitophagy
* Oxidative Phosphorylation
* Smoke
* Tobacco
|keywords=* COPD
* Cellular Senescence
* Exosomes
* Mesenchymal stem cells
* Mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894395
}}
==S100A9==
 
{{medline-entry
|title=Cigarette smoke induction of [[S100A9]] contributes to chronic obstructive pulmonary disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32964723
 
 
|keywords=* Cigarette smoke
* S100A9
* aging
* kinase
* pulmonary function
|full-text-url=https://sci-hub.do/10.1152/ajplung.00207.2020
}}
{{medline-entry
|title=Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32469975
 
|mesh-terms=* Aging
* Alzheimer Disease
* Animals
* Behavior, Animal
* Brain
* Disease Models, Animal
* Enzyme Inhibitors
* Epigenesis, Genetic
* Female
* Gene Expression
* Hippocampus
* Histone Demethylases
* Humans
* Male
* Memory Disorders
* Mice
* Mice, Inbred C57BL
* Mice, Mutant Strains
* Monoamine Oxidase Inhibitors
* Oxadiazoles
* Rats
* Rats, Sprague-Dawley
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259601
}}
{{medline-entry
|title=Cellular senescence induced by [[S100A9]] in mesenchymal stromal cells through NLRP3 inflammasome activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727865
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Calgranulin B
* Case-Control Studies
* Cell Line
* Cells, Cultured
* Cellular Reprogramming
* Cellular Senescence
* Female
* Humans
* Inflammasomes
* Interleukin-1beta
* Male
* Mesenchymal Stem Cells
* Middle Aged
* Myelodysplastic Syndromes
* NLR Family, Pyrin Domain-Containing 3 Protein
* Reactive Oxygen Species
* Signal Transduction
* Stem Cell Niche
* Toll-Like Receptor 4
* Up-Regulation
* Young Adult
|keywords=* NLRP3
* S100A9
* cellular senescence
* mesenchymal stromal cells
* myelodysplastic syndromes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874461
}}
{{medline-entry
|title=[[S100A9]] extends lifespan in insulin deficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391467
 
|mesh-terms=* Animals
* Calgranulin B
* Diabetes Mellitus, Experimental
* Diphtheria Toxin
* Fatty Acids
* Humans
* Hyperglycemia
* Insulin
* Leptin
* Liver
* Longevity
* Male
* Mice
* Mice, Knockout
* Oxidation-Reduction
* Signal Transduction
* Streptozocin
* Toll-Like Receptor 4
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686003
}}
==S100B==
 
{{medline-entry
|title=Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064981
 
 
|keywords=* Aging
* LDH
* S100B
* edema
* oxygen-glucose deprivation
|full-text-url=https://sci-hub.do/10.1080/00207454.2020.1730830
}}
==S1PR1==
 
{{medline-entry
|title=Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32544390
 
 
|keywords=* aging
* endothelial cell
* fibrosis
* kidney repair
* lipoprotein
* lung regeneration
* sphingosine-1-phosphate receptor
* vascular barrier
* vascular niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607448
}}
==SAG==
 
{{medline-entry
|title=WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634860
 
 
|keywords=*
WRKY42
 
* Arabidopsis
* leaf senescence
* reactive oxygen species
* salicylic acid
|full-text-url=https://sci-hub.do/10.1111/tpj.14914
}}
{{medline-entry
|title=Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32165493
 
|mesh-terms=* Adult Stem Cells
* Aging
* Animals
* Animals, Genetically Modified
* Basic Helix-Loop-Helix Transcription Factors
* Cell Differentiation
* Ear, Inner
* Embryo, Nonmammalian
* Ganglia, Sensory
* Gene Expression Regulation, Developmental
* Hair Cells, Auditory
* Larva
* Nerve Tissue Proteins
* Nestin
* Neural Stem Cells
* Neurogenesis
* Sensory Receptor Cells
* Stem Cell Niche
* Zebrafish
|keywords=* Inner ear
* Neuronal stem cells
* PNS
* Zebrafish
|full-text-url=https://sci-hub.do/10.1242/dev.176750
}}
==SAT1==
 
{{medline-entry
|title=Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32544364
 
 
|keywords=* Acetylation
* SAT1
* aging
* autophagy
* copper
* metabolomics
* obesity
* spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469548
}}
==SATB1==
 
{{medline-entry
|title=Loss of [[SATB1]] Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31543366
 
|mesh-terms=* Aging
* Animals
* Cells, Cultured
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* Dopaminergic Neurons
* Epigenetic Repression
* Gene Knockdown Techniques
* Humans
* Matrix Attachment Region Binding Proteins
* Mice
* Mice, Knockout
* Mitosis
* Parkinson Disease
* Protein Binding
|keywords=* Parkinson’s disease
* SATB1
* cellular senescence
* dopamine
* neurodegeneration
* neuroinflammation
* p21
* senolytics
* stem cells
* transcriptomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493192
}}
==SCD==
 
{{medline-entry
|title=Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160420
 
 
|keywords=* Aging
* Decision-making
* Mild cognitive impairment
* Subjective cognitive decline
* Transcranial direct current stimulation
* Transfer
* Working memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648990
}}
{{medline-entry
|title=Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33110409
 
 
|keywords=* Alzheimer’s disease
* aging
* blood pressure
* mild cognitive impairment
* subjective cognitive decline
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488384
}}
{{medline-entry
|title=Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067996
 
 
|keywords=* aging
* cognitive impairment
* neuropsychological assessment
|full-text-url=https://sci-hub.do/10.1093/arclin/acaa085
}}
{{medline-entry
|title=Subjective cognitive decline as a predictor of future cognitive decline: a systematic review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973979
 
 
|keywords=* Alzheimer disease.
* aging
* cognition
* cognitive dysfunction
* dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500809
}}
{{medline-entry
|title=Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32974042
 
 
|keywords=* Aging
* Functional assessment
* Geriatric assessment
* Geriatrics
* Older adults
* Sickle cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495855
}}
{{medline-entry
|title=Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32510658
 
 
|keywords=* Germany
* cognitive aging
* cognitive complaints
* cohort study
* prevalence
* subjective cognitive decline
|full-text-url=https://sci-hub.do/10.1002/gps.5359
}}
{{medline-entry
|title=SC411 treatment can enhance survival in a mouse model of sickle cell disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32447175
 
 
|keywords=* Aging
* Cerebral blood flow
* Docosahexaenoic acid
* Neuroinflammation
* Sickle cell disease
* Working memory
|full-text-url=https://sci-hub.do/10.1016/j.plefa.2020.102110
}}
{{medline-entry
|title=DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416007
 
 
|keywords=* DNA longevity
* sperm DNA damage
* sperm DNA dynamics
* sperm DNA fragmentation
* sperm chromatin dispersion test
|full-text-url=https://sci-hub.do/10.1111/andr.12819
}}
{{medline-entry
|title=Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388509
 
 
|keywords=* Alzheimer’s disease
* Brain aging
* Cognitive decline
* Cognitive testing
* Longitudinal studies
* Psychometric cognition
|full-text-url=https://sci-hub.do/10.1159/000507286
}}
{{medline-entry
|title=Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32363431
 
 
|keywords=* Aging
* Biochemistry
* Cognition
* Dementia
* Geriatric medicine
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01572-6
}}
{{medline-entry
|title=Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32010049
 
 
|keywords=* activity participation
* aging
* daily functioning
* metamemory
* subjective cognitive decline
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974583
}}
{{medline-entry
|title=Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32023499
 
 
|keywords=* Aging
* Electrical risk score
* Gender
* Mortality
* QTc
* Repolarization phase
* T peak-tend interval
|full-text-url=https://sci-hub.do/10.1016/j.jelectrocard.2020.01.009
}}
{{medline-entry
|title=Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31915725
 
 
|keywords=* Aging
* Chronic disease
* Cognitive dysfunction
* Dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938465
}}
{{medline-entry
|title=Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920589
 
 
|keywords=* Alzheimer’s disease
* aging
* biomarkers
* cerebrovascular health
* signal variability
* subjective cognitive decline
* white matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936515
}}
{{medline-entry
|title=Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730182
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Anemia, Sickle Cell
* Child
* Child, Preschool
* Cohort Studies
* Female
* Forecasting
* Humans
* Income
* Infant
* Life Expectancy
* Male
* Middle Aged
* Models, Statistical
* Quality-Adjusted Life Years
* United States
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902797
}}
{{medline-entry
|title=Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703450
 
 
|keywords=* Compostela aging study
* cluster analysis
* cognitive aging
* dementia
* mild cognitive impairment
* screening and diagnosis
* subjective cognitive complaints
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895967
}}
{{medline-entry
|title=Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31522594
 
|mesh-terms=* Aged
* Aging
* Brain Waves
* Cerebral Cortex
* Cognitive Dysfunction
* Cortical Synchronization
* Female
* Humans
* Magnetoencephalography
* Male
* Memory, Short-Term
* Task Performance and Analysis
|keywords=* Alzheimer’s disease (AD)
* Induced oscillatory activity
* magnetoencephalography (MEG)
* mild cognitive impairment (MCI)
* subjective cognitive decline (SCD)
* working memory (WM)
|full-text-url=https://sci-hub.do/10.1142/S0129065719500199
}}
{{medline-entry
|title=Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31466053
 
|mesh-terms=* Aged
* Aged, 80 and over
* Corpus Callosum
* Diffusion Tensor Imaging
* Female
* Frontal Lobe
* Functional Laterality
* Humans
* Magnetic Resonance Imaging
* Male
* Memory Disorders
* Middle Aged
* Nerve Fibers
* Neuropsychological Tests
* Retrospective Studies
* Surveys and Questionnaires
* Taiwan
|keywords=* Aging
* Alzheimer’s disease
* Cognitive complaints
* Diffusion tensor imaging
* Lateralization
* Prospective memory
* Tract-based spatial statistics
|full-text-url=https://sci-hub.do/10.1159/000501366
}}
==SCN2A==
 
{{medline-entry
|title=Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31501495
 
|mesh-terms=* Aging
* Animals
* Autism Spectrum Disorder
* Gene Knockout Techniques
* Haploinsufficiency
* Memory
* Mice
* NAV1.2 Voltage-Gated Sodium Channel
* Phenotype
* Spatial Learning
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733925
}}
==SCN2B==
 
{{medline-entry
|title=MicroRNA‑449a regulates the progression of brain aging by targeting [[SCN2B]] in SAMP8 mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32124967
 
|mesh-terms=* Aging
* Animals
* Brain
* Gene Expression Regulation
* Male
* Mice
* Mice, Transgenic
* MicroRNAs
* Voltage-Gated Sodium Channel beta-2 Subunit
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053848
}}
==SCO1==
 
{{medline-entry
|title=Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219749
 
 
|keywords=* Caenorhabditis elegans
* Energy metabolism
* Longevity
* TaqMan real-time PCR
* p53/CEP-1
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_12
}}
==SDC1==
 
{{medline-entry
|title=Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/[[SDC1]] axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33042414
 
 
|keywords=* Atherosclerosis
* MiR-665
* SDC1
* olmesartan
* vascular smooth muscle cell senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540088
}}
{{medline-entry
|title=Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32530114
 
 
|keywords=* FGFR1
* SDC1
* cellular senescence
* endocytosis
* heparan sulfation
|full-text-url=https://sci-hub.do/10.1096/fj.201902714R
}}
==SDHB==
 
{{medline-entry
|title=Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32059608
 
 
|keywords=* aging
* biomarkers
* exosomes
* mitochondrial dynamics
* mitochondrial quality control
* mitochondrial-derived vesicles
* mitochondrial-lysosomal axis
* mitophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074517
}}
==SDS==
 
{{medline-entry
|title=Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32946050
 
 
|keywords=* Aging skeletal muscle
* Morphometric analysis
* Myosin heavy chain
* Semiautomatic muscle analysis
* Skeletal muscle
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00266-1
}}
{{medline-entry
|title=Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32858432
 
 
|keywords=* Aging
* Annual fish
* Lifespan
* Nothobranchius
* Salidroside
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104233
}}
{{medline-entry
|title=Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32831297
 
|mesh-terms=* Aging
* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Longevity
* Protein Aggregates
* Proteome
* Proteomics
* Workflow
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519758
}}
{{medline-entry
|title=Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31936810
 
 
|keywords=* aging
* myofibrillar protein
* proteomics
* resistance training
* sarcoplasmic protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022975
}}
{{medline-entry
|title=Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31694618
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Catalase
* Drugs, Chinese Herbal
* Galactose
* Humans
* Kidney
* Liver
* Male
* Malondialdehyde
* Mice
* Mice, Inbred ICR
* Molecular Weight
* Oxidative Stress
* Plant Proteins
* Plant Roots
* Superoxide Dismutase
|keywords=* Antioxidant activity
* D-galactose
* Oxidative damage
* Protein composition
* Radix isatidis protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836523
}}
{{medline-entry
|title=[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31621246
 
|mesh-terms=* Animals
* Apoptosis
* Drosophila melanogaster
* Longevity
* Metal Nanoparticles
* Oregon
* Silver
|keywords=* Drosophila melanogaster
* apoptosis
* protein expression
* silver nanoparticles
|full-text-url=https://sci-hub.do/10.13287/j.1001-9332.201910.036
}}
{{medline-entry
|title=Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480678
 
|mesh-terms=* Adolescent
* Aging
* Behavior Therapy
* Cognitive Behavioral Therapy
* Female
* Humans
* Male
* Weight Loss
* Weight Reduction Programs
* Young Adult
|keywords=* adolescents
* behavioral weight loss
* controlled trial
* emerging adults
* obesity
* quality of life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769959
}}
==SELENBP1==
 
{{medline-entry
|title=A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31557719
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Cytoplasm
* Drug Resistance
* Gene Expression Regulation
* Humans
* Longevity
* Membrane Proteins
* Oxidative Stress
* Paraquat
* Selenious Acid
* Selenium-Binding Proteins
* Structural Homology, Protein
|keywords=* Caenorhabditis elegans
* Lifespan
* Selenium-binding protein
* Stress signaling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812014
}}
==SELENOK==
 
{{medline-entry
|title=Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736983
 
 
|keywords=* Female fertility
* Ovarian aging
* Selenium
* Selenoprotein K
* Selenoprotein M
|full-text-url=https://sci-hub.do/10.1016/j.repbio.2020.07.006
}}
==SENP6==
 
{{medline-entry
|title=Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32827359
 
 
|keywords=* Pax6
* SUMO1
* SUMO2/3
* aging
* apoptosis
* cataract
* de-sumoylation enzymes (SENPs)
* sumoylation ligases
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576240
}}
==SERPINE1==
 
{{medline-entry
|title=Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056555
 
 
|keywords=* Endothelial aging
* Endothelial cells
* HtrA4
* Preeclampsia
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2019.12.012
}}
==SESN2==
 
{{medline-entry
|title=Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i][[SESN2]][/i] Have a Role in Age-related Different Prognoses?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32859642
 
 
|keywords=* Papillary thyroid cancer
* SESN2
* aCGH
* deletion
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472442
}}
==SFN==
 
{{medline-entry
|title=The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160067
 
 
|keywords=* Aging
* Hormesis
* Inflammation
* Neuroprotection
* Nrf2
* Sulforaphane
|full-text-url=https://sci-hub.do/10.1016/j.phrs.2020.105283
}}
{{medline-entry
|title=Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33003447
 
 
|keywords=* aging
* biomarkers
* gut microbiome
* metabolome
* sulforaphane
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599699
}}
{{medline-entry
|title=Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659677
 
 
|keywords=* Coculture system
* Collagen homeostasis
* Melanogenesis
* Particulate matter 2.5
* Premature skin aging
* Sulforaphane
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153276
}}
{{medline-entry
|title=Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32476238
 
 
|keywords=* ROS
* autophagy
* exosome
* senescence
* sulforaphane
|full-text-url=https://sci-hub.do/10.1002/mnfr.201901231
}}
==SFPQ==
 
{{medline-entry
|title=Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267831
 
 
|keywords=* IL-8
* NORAD
* cell apoptosis
* cell senescence
* ox-LDL
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185106
}}
==SGK1==
 
{{medline-entry
|title=Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223380
 
 
|keywords=* AKT
* EZH2
* aging
* mTOR
* p53
|full-text-url=https://sci-hub.do/10.1161/HYPERTENSIONAHA.120.14642
}}
==SHBG==
 
{{medline-entry
|title=Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337470
 
 
|keywords=* aging
* cardiovascular events
* men
* testosterone
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173399
}}
{{medline-entry
|title=Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900485
 
 
|keywords=* aging
* atherosclerosis
* carotid artery
* hormones
* women
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077951
}}
{{medline-entry
|title=Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31877849
 
|mesh-terms=* Absorptiometry, Photon
* Aged
* Aging
* Androgens
* Biomarkers
* Bone Density
* Bone Remodeling
* Bone and Bones
* Collagen Type I
* Dehydroepiandrosterone Sulfate
* Estradiol
* Humans
* Male
* Middle Aged
* Parathyroid Hormone
* Peptide Fragments
* Peptides
* Procollagen
* Sex Hormone-Binding Globulin
* Testosterone
|keywords=* aging men
* biochemical bone markers
* levels of androgens
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982106
}}
{{medline-entry
|title=Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408149
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Community-Based Participatory Research
* Cross-Sectional Studies
* Dehydroepiandrosterone
* Estrone
* Female
* Follow-Up Studies
* Humans
* Obesity
* Overweight
* Prognosis
* Testosterone
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830527
}}
==SHD==
 
{{medline-entry
|title=Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33036703
 
|mesh-terms=* Activities of Daily Living
* Aged
* Aged, 80 and over
* Cognition
* Cognitive Dysfunction
* Cohort Studies
* Disabled Persons
* Female
* Health Status
* Hearing Loss
* Humans
* Longevity
* Longitudinal Studies
* Male
* Mental Status and Dementia Tests
* Odds Ratio
* Self Report
* Social Isolation
|keywords=* Cognitive impairment
* Older people
* Physical disability
* Self-reported hearing difficulty
* Social isolation
|full-text-url=https://sci-hub.do/10.1016/j.maturitas.2020.06.011
}}
==SHH==
 
{{medline-entry
|title=Recent advances in [[SHH]] medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31700613
 
|mesh-terms=* Animals
* Cerebellar Neoplasms
* Cerebellum
* Hedgehog Proteins
* Humans
* Medulloblastoma
* Mice
* Tumor Microenvironment
|keywords=* Medulloblastoma
* Sonic hedgehog
* cell senescence
* tumor microenvironment
* tumor progression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820827
}}
==SI==
 
{{medline-entry
|title=Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33074466
 
 
|keywords=* Aging
* Biomarkers
* Sex differences
* Social isolation
* Stroke
* miRNAs
|full-text-url=https://sci-hub.do/10.1007/s12017-020-08622-2
}}
{{medline-entry
|title=Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32290168
 
|mesh-terms=* Aging
* Cardiovascular Diseases
* Diabetes Mellitus, Type 2
* Female
* Fingers
* Heart Rate
* Humans
* Male
* Microcirculation
* Photoplethysmography
* Vascular Stiffness
|keywords=* cardiovascular disease
* heart rate
* photoplethysmography
* reflection index
* second derivative of photoplethysmography
* stiffness index
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177218
}}
{{medline-entry
|title=Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32161695
 
 
|keywords=* elderly
* geriatrics
* palliative medicine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060293
}}
{{medline-entry
|title=Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109694
 
|mesh-terms=* Aged
* Aged, 80 and over
* Cohort Studies
* Depression
* Diet, Mediterranean
* Healthy Aging
* Humans
* Multimorbidity
* Surveys and Questionnaires
|keywords=* Aging
* Depressive symptoms
* Mediterranean diet
* Mental health
* Multimorbidity
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104022
}}
{{medline-entry
|title=Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31860831
 
 
|keywords=* accelerometry
* aging
* health
* social well-being
* volunteering
|full-text-url=https://sci-hub.do/10.1123/japa.2019-0027
}}
{{medline-entry
|title=The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31650846
 
 
|keywords=* Chinese American
* Social support
* aging
* negative social interaction
* suicidal ideation
|full-text-url=https://sci-hub.do/10.1080/13607863.2019.1680953
}}
{{medline-entry
|title=Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553444
 
|mesh-terms=* Aged, 80 and over
* Aging
* Brain
* Cellular Senescence
* Cerebral Arteries
* Cerebral Small Vessel Diseases
* Female
* Humans
* Male
* White Matter
|keywords=* Brain aging
* Cerebrovascular disease
* Senescence
* Small vessel disease
|full-text-url=https://sci-hub.do/10.1093/jnen/nlz088
}}
==SIK3==
 
{{medline-entry
|title=Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566214
 
 
|keywords=* Age-related phenotypes
* Aging
* Genome-wide association studies
* Health span
* Life span
* Pleiotropy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518561
}}
==SIRT1==
 
{{medline-entry
|title=Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274583
 
 
|keywords=* NO
* SIRT1
* anthocyanins
* eNOS deacetylation
* senescence
|full-text-url=https://sci-hub.do/10.1111/acel.13279
}}
{{medline-entry
|title=Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280374
 
 
|keywords=* Aging
* neurodegenerative diseases
* neuroprotective
* sirtuin
* sirtuin activators
* sirtuin inhibitors
|full-text-url=https://sci-hub.do/10.1021/acschemneuro.0c00696
}}
{{medline-entry
|title=Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149857
 
 
|keywords=* Cellular senescence
* Diabetes
* Diabetes complications
* Endothelial cells
* Garcinia mangostana
* Hyperglycemia
* Mangostin
* Metabolic syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585532
}}
{{medline-entry
|title=[[SIRT1]] Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33158256
 
 
|keywords=* CRISPR/dCas9
* SIRT1
* corneal endothelial cells
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694272
}}
{{medline-entry
|title=Histone Deacetylase [[SIRT1]], Smooth Muscle Cell Function, and Vascular Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117155
 
 
|keywords=* SIRT1
* SIRT1 activators
* calorie restriction
* senescence
* vascular diseases
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573826
}}
{{medline-entry
|title=6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing [[SIRT1]] and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33111210
 
 
|keywords=* 6,4′-dihydroxy-7-methoxyflavanone
* Akt
* Oxidative stress
* Premature senescence
* SIRT1
|full-text-url=https://sci-hub.do/10.1007/s11010-020-03951-z
}}
{{medline-entry
|title=Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through [[SIRT1]] activation and AKT/mTOR pathway inhibition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010892
 
 
|keywords=* AKT/mTOR signaling pathway
* Antioxidant: SIRT1
* Cellular senescence
* Isoparvifuran
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.09.096
}}
{{medline-entry
|title=[[SIRT1]] Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013385
 
 
|keywords=* 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside
* SIRT1
* human umbilical vein cells
* hydrogen peroxide
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508177
}}
{{medline-entry
|title=The Role of Sirtuins in Kidney Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932720
 
 
|keywords=* acute kidney injury
* aging kidney
* chronic kidney disease
* diabetic nephropathy
* kidney
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555196
}}
{{medline-entry
|title=The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32919015
 
 
|keywords=* Cellular senescence
* Elderly
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111090
}}
{{medline-entry
|title=Virus-Induced Asthma Exacerbations: [[SIRT1]] Targeted Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32823491
 
 
|keywords=* SIRT1
* asthma
* cellular senescence
* exacerbations
* virus infection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464235
}}
{{medline-entry
|title=Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793997
 
 
|keywords=* Resveratrol
* SIRT1
* Senescence
* Toxicity
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09896-6
}}
{{medline-entry
|title=Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-FOXA3-Beclin1 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768436
 
 
|keywords=* Beclin1
* Endothelial cells
* FOXA3
* Glucose restriction
* Proliferation
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111053
}}
{{medline-entry
|title=Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32722945
 
 
|keywords=* Sirtuin 1
* alveolar epithelial cells
* cellular senescence
* chronic obstructive pulmonary disease
* cigarette smoking
|full-text-url=https://sci-hub.do/10.1080/15412555.2020.1797657
}}
{{medline-entry
|title=Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of [[SIRT1]] in Human Dermal Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32404543
 
 
|keywords=* human dermal fibroblast
* latifolin
* mammalian target of rapamycin
* oxidative stress
* senescence
* silent information regulator 1
|full-text-url=https://sci-hub.do/10.1248/bpb.b20-00094
}}
{{medline-entry
|title=SRT1720-induced activation of [[SIRT1]] alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32421926
 
 
|keywords=* SIRT1
* SRT1720
* VSMC senescence
* p-AMPK (Ser485)
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327920
}}
{{medline-entry
|title=miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32292498
 
 
|keywords=* PMOP
* aging
* inflammation
* miR-128
* osteoclastogenesis
* ovariectomy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150474
}}
{{medline-entry
|title=Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270742
 
 
|keywords=* CD28nullCD8+ T and NKT-like cells
* COPD
* IFNγ and TNFα
* SIRT1
* lymphocyte senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153179
}}
{{medline-entry
|title=Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249404
 
 
|keywords=* Aging
* Ashwagandha
* Circadian clock
* NRF2
* SCN
* SIRT1
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09875-x
}}
{{medline-entry
|title=The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32214805
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Biomarkers
* Blood Pressure
* Cardiovascular Diseases
* Case-Control Studies
* Diabetes Complications
* Echocardiography
* Female
* Glucuronidase
* Heart Ventricles
* Humans
* Kidney
* Kidney Failure, Chronic
* Male
* Middle Aged
* Renal Dialysis
* Sirtuin 1
* Stroke Volume
|keywords=* chronic kidney disease
* hemodialysis
* sirtuin1
* αKlotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084123
}}
{{medline-entry
|title=Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158519
 
 
|keywords=* Cellular senescence
* DNMT1
* SIRT1
* extracellular vesicles
* microRNAs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048230
}}
{{medline-entry
|title=Spatiotemporal gating of [[SIRT1]] functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32152092
 
|mesh-terms=* Acetylglucosamine
* Aging
* Animals
* Fasting
* Gluconeogenesis
* Glycosylation
* HEK293 Cells
* Homeostasis
* Humans
* Hyperglycemia
* Insulin Resistance
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Obesity
* Phosphorylation
* Protein Processing, Post-Translational
* Sirtuin 1
* Spatio-Temporal Analysis
|keywords=* PGC1α
* fed–fast cycle
* gluconeogenesis
* insulin signaling
* ubiquitinylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104039
}}
{{medline-entry
|title=Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132865
 
 
|keywords=* SIRT1
* cell senescence
* homocysteine
* hydrogen sulfide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053352
}}
{{medline-entry
|title=[[SIRT1]] and aging related signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32084459
 
 
|keywords=* Aging
* Deacetylate
* NAD(+)
* SIRT1
* Signaling pathways
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111215
}}
{{medline-entry
|title=Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of [[SIRT1]] signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32088214
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Apoptosis
* Brain
* Drug Administration Schedule
* Galactose
* Gene Expression Regulation
* Inflammation
* Injections, Intraperitoneal
* Injections, Subcutaneous
* Interleukin-6
* Male
* Mice
* Mitochondria
* Neurons
* Nitric Oxide
* Oxidative Stress
* Proto-Oncogene Proteins c-bcl-2
* Reactive Oxygen Species
* Serotonin 5-HT3 Receptor Antagonists
* Sirtuin 1
* Tropisetron
* Tumor Necrosis Factor-alpha
* bcl-2-Associated X Protein
|keywords=* Aging
* Brain
* Neurotoxicity
* Sirtuin 1
* Tropisetron
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117452
}}
{{medline-entry
|title=Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of [[SIRT1]] activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056076
 
 
|keywords=* Aging
* Geroscience
* Mitochondria dysfunction
* Transcriptomics
* Vascular cognitive impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206476
}}
{{medline-entry
|title=Deacetylation of MRTF-A by [[SIRT1]] defies senescence induced down-regulation of collagen type I in fibroblast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061777
 
|mesh-terms=* Acetylation
* Animals
* Benzamides
* Carbazoles
* Cellular Senescence
* Collagen Type I
* Down-Regulation
* Embryo, Mammalian
* Fibroblasts
* HEK293 Cells
* Heterocyclic Compounds, 4 or More Rings
* Humans
* Mice
* Mutation
* Naphthols
* Primary Cell Culture
* Promoter Regions, Genetic
* RNA, Small Interfering
* Resveratrol
* Sirtuin 1
* Trans-Activators
|keywords=* Collagen type I
* Fibroblast
* Lysine deacetylation
* Post-translational modification
* Senescence
* Transcriptional regulation
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165723
}}
{{medline-entry
|title=Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal [[SIRT1]] Levels Improving Cognition in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991916
 
|mesh-terms=* Age Factors
* Animals
* Behavior, Animal
* Biogenic Monoamines
* Catechin
* Cognition
* Cognitive Aging
* Corpus Striatum
* Hippocampus
* Male
* Memory, Episodic
* Memory, Short-Term
* Neuroprotective Agents
* Rats, Sprague-Dawley
* Sirtuin 1
* Time Factors
|keywords=* NF-κB
* RBAP46/48
* SIRT1
* brain aging
* brain monoamine synthesis
* catechin
* green tea
* memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071257
}}
{{medline-entry
|title=Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970335
 
 
|keywords=* SIRT1
* angiotensin II
* duck oil
* nanoemulsion
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957441
}}
{{medline-entry
|title=Two novel [[SIRT1]] activators, SCIC2 and SCIC2.1, enhance [[SIRT1]]-mediated effects in stress response and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942817
 
 
|keywords=* Sirtuins
* drug discovery
* epigenetic modulators
* senescence
* stress response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574383
}}
{{medline-entry
|title=Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881011
 
|mesh-terms=* A549 Cells
* Alveolar Epithelial Cells
* Apoptosis
* Cellular Senescence
* Humans
* Hydrogen Sulfide
* Mitochondria
* Oxidative Stress
* Sirtuin 1
* Smoke
* Tobacco
* Up-Regulation
|keywords=* alveolar epithelial cell
* cigarette smoke extract
* hydrogen sulfide
* mitochondria injury
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949053
}}
{{medline-entry
|title=The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852248
 
|mesh-terms=* Adipokines
* Caveolin 1
* Cell Line, Tumor
* Cellular Senescence
* Chondrocytes
* Cyclin-Dependent Kinase Inhibitor p21
* Cytoprotection
* G1 Phase Cell Cycle Checkpoints
* Humans
* Interleukin-1beta
* Plasminogen Activator Inhibitor 1
* Sirtuin 1
* Transcriptional Activation
|keywords=* IL-1β
* Omentin-1
* SIRT-1
* chondrocyte senescence
|full-text-url=https://sci-hub.do/10.1080/21691401.2019.1699803
}}
{{medline-entry
|title=The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD  Level Is Lower than the Sirtuin-Saturating Concentrations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31878234
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Caloric Restriction
* Cell Line
* Humans
* NAD
* Niacin
* Sirtuins
* beta-Galactosidase
|keywords=* C. elegans
* Hs68 cells
* NAD+
* calorie restriction mimetic
* lifespan
* nicotinic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340
}}
{{medline-entry
|title=Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792920
 
 
|keywords=* Alpha-mangostin
* Diabetes
* HUVEC
* High glucose
* SIRT1
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214571
}}
{{medline-entry
|title=Central nervous system [[SIRT1]] expression is required for cued and contextual fear conditioning memory responses in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31763496
 
 
|keywords=* Fear conditioning
* SIRT1
* aging
* classically conditioned memory
* hippocampus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839599
}}
{{medline-entry
|title=Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785216
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aging
* Aging, Premature
* Educational Status
* Epigenesis, Genetic
* Female
* Gene Expression Regulation, Enzymologic
* Histones
* Humans
* Learning
* Male
* Middle Aged
* Sirtuins
* Young Adult
 
 
}}
{{medline-entry
|title=CO ameliorates endothelial senescence induced by 5-fluorouracil through [[SIRT1]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704100
 
|mesh-terms=* Antioxidants
* Carbon Monoxide
* Cellular Senescence
* Down-Regulation
* Fluorouracil
* Heme Oxygenase-1
* Human Umbilical Vein Endothelial Cells
* Humans
* Nitric Oxide Synthase Type III
* Reactive Oxygen Species
* Sirtuin 1
|keywords=* 5-Fluorouracil
* Carbon monoxide
* Endothelial senescence
* Reactive oxygen species
* SIRT1
|full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108185
}}
{{medline-entry
|title=Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating [[SIRT1]] expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31631065
 
|mesh-terms=* Aging
* Animals
* Argonaute Proteins
* Cell Proliferation
* Diabetes Mellitus, Experimental
* Diabetic Nephropathies
* Fibrosis
* Gene Deletion
* Gene Expression Regulation
* Glucose
* Male
* Mesangial Cells
* Mice
* MicroRNAs
* RAW 264.7 Cells
* RNA, Long Noncoding
* Rats
* Rats, Sprague-Dawley
* Sirtuin 1
|keywords=* diabetic nephropathy
* fibrosis
* lncRNA GAS5
* proliferation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834398
}}
{{medline-entry
|title=The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31572218
 
 
|keywords=* PVAT
* SIRT1
* eNOS
* vascular aging
* vascular remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751260
}}
{{medline-entry
|title=Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544977
 
 
|keywords=* Abrus agglutinin
* LAMP1
* SIRT1
* free fatty acid
* lipophagy
* reactive oxygen species
* senescence
|full-text-url=https://sci-hub.do/10.1002/jcp.29182
}}
{{medline-entry
|title=Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552414
 
 
|keywords=* CPAP
* OSA
* aging
* cardiovascular
* endothelium
* exosomes
* extracellular vesicles
* intermittent hypoxia
* oxidative stress
* senescence
|full-text-url=https://sci-hub.do/10.1093/sleep/zsz217
}}
{{medline-entry
|title=Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481873
 
 
|keywords=* SIRT1
* autophagic flux
* high glucose
* hydrogen sulfide
* neuronal senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710442
}}
{{medline-entry
|title=Activation of the miR-34a-Mediated [[SIRT1]]/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31420820
 
|mesh-terms=* Aging
* Animals
* Brain
* Coumarins
* Galactose
* Male
* Mice
* Mice, Inbred ICR
* MicroRNAs
* PC12 Cells
* Random Allocation
* Rats
* Signal Transduction
* Sirtuin 1
* TOR Serine-Threonine Kinases
|keywords=* D-Gal
* SIRT1/mTOR signal pathway
* Urolithin A
* aging
* autophagy
* miR-34a
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985387
}}
==SIRT2==
 
{{medline-entry
|title=Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the [[SIRT2]]-dependent H4K16 deacetylation pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31980591
 
 
|keywords=* aging
* histone acetylation
* meiosis
* melatonin
* oocyte quality
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053624
}}
==SIRT3==
 
{{medline-entry
|title=[[SIRT3]] protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160987
 
 
|keywords=* Endothelial senescence
* High glucose
* SIRT3
* p53
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118724
}}
{{medline-entry
|title=Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143333
 
 
|keywords=* aging
* arterial hypertension
* buccal epithelium
* melatonin
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662974
}}
{{medline-entry
|title=[i][[SIRT3]][/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228121
 
 
|keywords=* O-hMSC transplantation
* SIRT3
* aging
* gene modification
* myocardial infarction
* myocardial repair
|full-text-url=https://sci-hub.do/10.1089/rej.2019.2260
}}
{{medline-entry
|title=17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating [[SIRT3]] expression and promoting autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172411
 
 
|keywords=* 17β-estradiol
* Autophagy
* SIRT3
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09868-w
}}
{{medline-entry
|title=CR6 interacting factor 1 deficiency induces premature senescence via [[SIRT3]] inhibition in endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109515
 
 
|keywords=* Antioxidant system
* Mitochondria
* Oxidative stress
* Senescence
* Vascular endothelial cell
|full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2020.02.017
}}
{{medline-entry
|title=Mitochondrial function in skeletal myofibers is controlled by a TRF2-[[SIRT3]] axis over lifetime.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991048
 
 
|keywords=* aging
* mitochondria
* postmitotic cells
* skeletal muscle
* telomeres
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059141
}}
{{medline-entry
|title=Context-Dependent Roles for SIRT2 and [[SIRT3]] in Tumor Development Upon Calorie Restriction or High Fat Diet.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970087
 
 
|keywords=* SIRT2
* SIRT3
* aging
* calorie restriction
* cancer
* high fat diet
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960403
}}
{{medline-entry
|title=The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31740222
 
|mesh-terms=* Aging
* Animals
* Cardiovascular Diseases
* Humans
* Metabolic Diseases
* Mitochondria
* Neurodegenerative Diseases
* Protein Isoforms
* Sirtuin 3
|keywords=* Age-related diseases
* Deacetylation
* Genetic manipulations
* Mitochondria
* Pharmacological modulators
* Sirtuins
|full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100983
}}
==SIRT5==
 
{{medline-entry
|title=Lysine malonylation and propionylation are prevalent in human lens proteins.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678036
 
|mesh-terms=* Aging
* Animals
* Blotting, Western
* Chromatography, Liquid
* Crystallins
* Cytoskeletal Proteins
* Cytosol
* Epithelial Cells
* Humans
* Immunohistochemistry
* Lens, Crystalline
* Lysine
* Malonates
* Membrane Proteins
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Mitochondrial Proteins
* Organ Culture Techniques
* Paraffin Embedding
* Propionates
* Sirtuin 3
* Sirtuins
* Tandem Mass Spectrometry
|keywords=* Lens proteins
* Malonylation
* Mass spectrometry
* Propionylation
* Sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957740
}}
==SIRT6==
 
{{medline-entry
|title=Association between [[SIRT6]] Methylation and Human Longevity in a Chinese Population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238266
 
 
|keywords=* DNA Methylation
* Longevity
* Messenger RNA
* SIRT6
|full-text-url=https://sci-hub.do/10.1159/000508832
}}
{{medline-entry
|title=The [[SIRT6]] activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33089974
 
 
|keywords=* DNA repair
* MDL-800
* SIRT6
* aging
* genome integrity
* pluripotency
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431819
}}
{{medline-entry
|title=Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33098511
 
 
|keywords=* Alzheimer’s disease
* aging
* intravital diagnosis
* saliva
* sirtuins
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04986-4
}}
{{medline-entry
|title=Age-related epigenetic drift deregulates [i][[SIRT6]][/i] expression and affects its downstream genes in human peripheral blood mononuclear cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573339
 
 
|keywords=* SIRT6
* aging
* interaction network
* longevity
* methylation
* miRNA
* peripheral blood mononuclear cells (PBMCs)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678931
}}
{{medline-entry
|title=Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32518153
 
 
|keywords=* SIRT6
* activator
* aging
* cancer
* cell metabolism
* chromatin
* gene expression
* histone deacetylase (HDAC)
* longevity
* metabolic disorder
* sirtuin
* small molecule
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415977
}}
{{medline-entry
|title=Age-dependent role of [[SIRT6]] in jawbone via regulating senescence and autophagy of bone marrow stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32002721
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* Bone Marrow Cells
* Humans
* Jaw
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Knockout
* Middle Aged
* Osteogenesis
* Sirtuins
|keywords=* Autophagy
* Bone marrow stromal cells
* Jawbone
* Osteoporosis
* SIRT6
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s10735-020-09857-w
}}
{{medline-entry
|title=Mechanism of activation for the sirtuin 6 protein deacylase.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822559
 
|mesh-terms=* Allosteric Regulation
* Biocatalysis
* Fatty Acids
* HEK293 Cells
* Histones
* Humans
* Hydrophobic and Hydrophilic Interactions
* Kinetics
* Lipids
* Mutagenesis
* Mutation
* NAD
* Peptides
* Protein Binding
* Protein Conformation
* Sirtuins
* Small Molecule Libraries
|keywords=* SIRT6
* activator
* cancer
* chromatin
* deacetylation
* epigenetics
* histone
* histone deacetylase (HDAC)
* lifespan
* long chain acyl substrate
* longevity
* sirtuin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996886
}}
{{medline-entry
|title=Proteomics of Long-Lived Mammals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737995
 
 
|keywords=* SIRT6
* aging
* long-lived mammals
* naked mole rats
* proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117992
}}
{{medline-entry
|title=Sirtuins and [[SIRT6]] in Carcinogenesis and in Diet.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31591350
 
|mesh-terms=* Aging
* Animals
* Carcinogenesis
* Diet
* Gene Expression Regulation, Neoplastic
* Humans
* Nanomedicine
* Organ Specificity
* Sirtuins
|keywords=* SIRT6
* cancer
* chemotherapy
* diet
* modulator
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801518
}}
{{medline-entry
|title=[[SIRT6]]-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31399301
 
|mesh-terms=* Aging
* Animals
* Cells, Cultured
* Disease Models, Animal
* Endothelium, Vascular
* Epithelial-Mesenchymal Transition
* Gene Expression Regulation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* RNA, Long Noncoding
* Signal Transduction
* Sirtuins
* Vascular Diseases
 
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2019.07.082
}}
==SIRT7==
 
{{medline-entry
|title=[[SIRT7]] antagonizes human stem cell aging as a heterochromatin stabilizer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504224
 
 
|keywords=* LINE1
* SIRT7
* STING
* aging
* cGAS
* stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305295
}}
==SLA==
 
{{medline-entry
|title=Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32540272
 
 
|keywords=* Adjuvant
* Aging
* Influenza
* Mouse
* Nucleoprotein
* Vaccination
|full-text-url=https://sci-hub.do/10.1016/j.vaccine.2020.05.085
}}
{{medline-entry
|title=Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography ([[SLA]]) Using Statistical Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32486137
 
 
|keywords=* Taguchi methods
* additive manufacturing
* aging effect
* analysis of variance
* anisotropy
* design of experiments
* stereolithography
* surface roughness
* tensile testing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321476
}}
{{medline-entry
|title=The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369581
 
 
|keywords=*
         
            aged implant
         
       
*
         
            biological aging
         
       
*
         
            implant survival
         
       
*
         
            marginal bone resorption
         
       
*
         
            titanium dental implant
         
       
|full-text-url=https://sci-hub.do/10.1563/aaid-joi-D-19-00316
}}
==SLC16A7==
 
{{medline-entry
|title=Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33095951
 
 
|keywords=* GWAS
* KIAA0930
* MC1R
* SLCA45A2
* SNP
* Telangiectasia
* candidate gene approach
* epidemiology
* genetics
* pigmentation genes
* red veins
* skin aging
|full-text-url=https://sci-hub.do/10.1111/jdv.17014
}}
==SLC26A2==
 
{{medline-entry
|title=Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31914611
 
|mesh-terms=* Aging
* Animals
* Lumbar Vertebrae
* Male
* Mice
* Osteogenesis
* Phenotype
* Spondylolysis
* Sulfate Transporters
|keywords=* SLC26A2
* bone loss
* isthmic defect
* spondylolysis
* vertebral development
|full-text-url=https://sci-hub.do/10.1096/fj.201901040RR
}}
==SLC6A4==
 
{{medline-entry
|title=The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634774
 
|mesh-terms=* Aging
* Aging, Premature
* Animals
* Anxiety
* Brain-Derived Neurotrophic Factor
* Consciousness
* DNA Methylation
* Depression
* Disease Models, Animal
* Endocrine System
* Humans
* Models, Genetic
* Models, Psychological
* Neurotransmitter Agents
* Oxidative Stress
* Personality
* Psilocybin
* Psychotropic Drugs
* Research Design
* Serotonin Plasma Membrane Transport Proteins
* Stress, Psychological
* Telomere Shortening
|keywords=* Cellular senescence
* Depression
* Epigenetic clock
* Genetic aging
* Life extension
* Neurophenomenology
* Psilocybin
* Rejuvenation
* Rumination
* Senotherapy
* Telomeres
|full-text-url=https://sci-hub.do/10.1016/j.mehy.2019.109406
}}
==SMAD1==
 
{{medline-entry
|title=TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31779094
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Brain
* Data Mining
* Databases, Genetic
* Disease Progression
* Female
* Gene Expression Profiling
* Gliosis
* Homeodomain Proteins
* Humans
* Ligands
* Male
* Middle Aged
* Multiple Sclerosis
* Proteomics
* Receptors, Androgen
* Sequence Analysis, RNA
* Signal Transduction
* Smad1 Protein
* Spinal Cord
* Transforming Growth Factor beta1
* Up-Regulation
|keywords=* androgen receptor
* astrocytes
* homeobox A5
* multiple sclerosis
* spinal cord
* transforming growth factor beta 1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928867
}}
==SMAD2==
 
{{medline-entry
|title=Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31674011
 
|mesh-terms=* Aging
* Animals
* Class I Phosphatidylinositol 3-Kinases
* Collagen
* Disease Models, Animal
* Disease Progression
* Epithelium
* Male
* Mice, Mutant Strains
* Phosphorylation
* Prostate
* Prostatic Hyperplasia
* Prostatic Intraepithelial Neoplasia
* Prostatic Neoplasms
* Signal Transduction
* Smad2 Protein
* Stromal Cells
* Transforming Growth Factor beta
|keywords=* PIK3CA
* cancer
* collagen
* fibrosis
* mouse model
* prostate
* stroma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071816
}}
==SMAD3==
 
{{medline-entry
|title=Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744885
 
|mesh-terms=* Aging
* Animals
* Fibroblasts
* Fibrosis
* Gene Deletion
* Male
* Mice
* Myocardium
* Myofibroblasts
* Signal Transduction
* Sirtuins
* Smad3 Protein
* Transcriptional Activation
* Transforming Growth Factor beta
|keywords=* SIRT6 deacetylase
* SMAD transcription factor
* SMAD3
* TGF-beta signaling
* aging
* aging-associated fibrosis
* caloric restriction
* cardiac disease
* extracellular matrix (ECM)
* fibrosis
* sirtuin
* transforming growth factor beta (TGF-beta)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956532
}}
==SMN2==
 
{{medline-entry
|title=Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31589162
 
|mesh-terms=* Aging
* Autopsy
* Cell Survival
* Female
* Humans
* Male
* Motor Neurons
* Muscular Atrophy, Spinal
* Oligodeoxyribonucleotides, Antisense
* Spinal Cord
* Survival of Motor Neuron 2 Protein
|keywords=* Development
* Neurodegeneration
* Neurodevelopment
* Neuromuscular disease
* Neuroscience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819103
}}
==SMS==
 
{{medline-entry
|title=Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33104027
 
 
|keywords=* Aging
* Alzheimer’s disease
* cognitive impairment
* dementia
* motor activity
* music therapy
* social interaction
|full-text-url=https://sci-hub.do/10.3233/JAD-200521
}}
{{medline-entry
|title=Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659437
 
 
|keywords=* Aging
* Digital health
* Latino
* Physical activity
* Text-messaging
* mHealth
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351675
}}
==SNAP25==
 
{{medline-entry
|title=The Biological Foundations of Sarcopenia: Established and Promising Markers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457015
 
 
|keywords=* SNAP25
* aging
* biomarkers
* neuromuscular junction
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700259
}}
==SNCA==
 
{{medline-entry
|title=Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31758049
 
|mesh-terms=* Aging
* Alanine
* Amino Acid Substitution
* Animals
* Behavior, Animal
* Disease Models, Animal
* Dopaminergic Neurons
* Humans
* Locomotion
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Mutation, Missense
* Parkinson Disease
* Proline
* Threonine
* alpha-Synuclein
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874660
}}
==SND1==
 
{{medline-entry
|title=[Downregulation of [[SND1]] Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32543144
 
|mesh-terms=* Cellular Senescence
* Diploidy
* Down-Regulation
* Endonucleases
* Fibroblasts
* Humans
* Nuclear Proteins
|keywords=* Aging
* Cellular senescent
* SND1
* Senescence-associated-secretory-phenotype
|full-text-url=https://sci-hub.do/10.12182/20200560504
}}
==SOD1==
 
{{medline-entry
|title=[[SOD1]], more than just an antioxidant.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33259795
 
 
|keywords=* Aging
* Cancer
* Neurodegenerative diseases
* Post-translational modifications
* Superoxide dismutase 1
|full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108701
}}
{{medline-entry
|title=The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054065
 
 
|keywords=* 4-hydroxynonenal
* 8-hydroxyguanosine
* aging
* epididymis
* oxidative stress
* reactive oxygen species
* spermatozoa
* superoxide dismutase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071042
}}
{{medline-entry
|title=Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31406145
 
|mesh-terms=* Aging
* Amyotrophic Lateral Sclerosis
* Animals
* Cardiolipins
* Cholesterol Esters
* Disease Models, Animal
* Disease Progression
* Fatty Acids, Unsaturated
* Female
* Humans
* Lipid Droplets
* Lipid Metabolism
* Lipidomics
* Male
* Mass Spectrometry
* Motor Cortex
* Motor Neurons
* Mutation
* Oxidative Stress
* Rats
* Rats, Transgenic
* Spinal Cord
* Superoxide Dismutase-1
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691112
}}
==SOD2==
 
{{medline-entry
|title=Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of [[SOD2]] Based on a Transcriptomic Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198315
 
 
|keywords=* aortic calcification
* astaxanthin
* chronic kidney disease
* chronic kidney disease-mineral bone disorder
* oxidative stress
* reactive oxygen species
* senescence
* vascular calcification
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698184
}}
{{medline-entry
|title=Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153341
 
 
|keywords=* Cataract
* D-galactose
* aging
* alginate oligosaccharide
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/02713683.2020.1842456
}}
{{medline-entry
|title=Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32931795
 
|mesh-terms=* Antineoplastic Agents, Phytogenic
* Autophagy
* Biomarkers
* Cell Cycle
* Cell Line, Tumor
* Cellular Senescence
* Cyclohexanones
* Flavones
* Humans
* Melanoma
* Reactive Oxygen Species
* Superoxide Dismutase
* beta-Galactosidase
|keywords=* Alkyl protoflavone
* Flavonoid
* Melanoma
* Protoapigenone
* Semi-synthesis
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118419
}}
{{medline-entry
|title=Ginsenoside Rg1 protects against Sca-1  HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-[[SOD2]] signaling pathways in a γ-ray irradiation-induced aging mice model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32765665
 
 
|keywords=* SIRT1
* SIRT3
* aging
* ginsenoside Rg1
* hematopoietic progenitor cells
* hematopoietic stem cells
* senescence
* γ-ray irradiation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388550
}}
{{medline-entry
|title=Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32481725
 
 
|keywords=* 8-Oxo-guanine
* aging
* almond
* chlorogenic acid
* lipid peroxidation
* mitochondria
* oxidative stress
* protein carbonylation
* sirtuin
* superoxide dismutase
* yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345664
}}
{{medline-entry
|title=Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32427102
 
 
|keywords=* AKT
* aging
* apoptosis
* cell biology
* p53
* regenerative medicine
* senescence
* stem cells
* telomeres
* zebrafish
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237213
}}
{{medline-entry
|title=Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31844865
 
|mesh-terms=* Aging
* Animal Scales
* Animals
* Catalase
* Diet, High-Fat
* Disease Models, Animal
* Drosophila Proteins
* Drosophila melanogaster
* Female
* Fish Proteins
* Fishes
* Humans
* Longevity
* Male
* Malondialdehyde
* Oxidative Stress
* Peptides
* Superoxide Dismutase
 
|full-text-url=https://sci-hub.do/10.1039/c9fo01414d
}}
{{medline-entry
|title=Ellagic acid prolongs the lifespan of Drosophila melanogaster.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786733
 
 
|keywords=* Drosophila melanogaster
* Ellagic acid
* Gene expression
* Longevity
* Stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031466
}}
{{medline-entry
|title=Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642042
 
|mesh-terms=* Antioxidants
* Catalase
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Chlorella vulgaris
* DNA Damage
* Diploidy
* Fibroblasts
* Gene Expression
* Genes, p53
* Humans
* Male
* Mitogen-Activated Protein Kinase 14
* Molecular Chaperones
* Primary Cell Culture
* Signal Transduction
* Superoxide Dismutase
* Superoxide Dismutase-1
|keywords=* Chlorella vulgaris
* Fibroblasts
* Replicative senescence
* Senescence-associated genes
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05140-8
}}
{{medline-entry
|title=Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647296
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Glutathione Peroxidase
* Male
* Myocardium
* Oxidation-Reduction
* Rats
* Rats, Wistar
* Superoxide Dismutase
 
|full-text-url=https://sci-hub.do/10.33549/physiolres.934170
}}
{{medline-entry
|title=Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31659616
 
 
|keywords=* Aging
* Curcumin
* Hypertrophy
* Oxidative stress
* Yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942599
}}
==SOX13==
 
{{medline-entry
|title=In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520345
 
|mesh-terms=* Aging
* Computer Simulation
* Epistasis, Genetic
* Humans
* Promoter Regions, Genetic
* Renin
|keywords=* Aging
* Diseases of aging
* Gene expression
* Gene–gene interaction
* Genomics
* Longevity
* Renin-angiotensin system
* Topologically associated domains
|full-text-url=https://sci-hub.do/10.1007/s10522-019-09834-1
}}
==SOX2==
 
{{medline-entry
|title=Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592324
 
 
|keywords=* cell physical stimulus
* differentiation
* mesenchymal stem cells
* multipotency
* nanosecond pulsed electric fields
* senescence
|full-text-url=https://sci-hub.do/10.1002/term.3088
}}
{{medline-entry
|title=Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054231
 
 
|keywords=* Aging
* Mesenchymal Stromal Cell (MSC) Subpopulations
* Miniature Pig
* Octamerbinding Transcription Factor 4 (OCT4)
* Sex Determining Region Y-box 2 (SOX2)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054621
}}
{{medline-entry
|title=Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678344
 
|mesh-terms=* Aging
* Animals
* Cell Count
* Cell Differentiation
* Cell Lineage
* Hair Cells, Vestibular
* Mice
* Mice, Knockout
* Mice, Transgenic
* SOXB1 Transcription Factors
* Saccule and Utricle
|keywords=* SOX2
* balance disorder
* hair cell
* utricle
* vestibule
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2019.09.027
}}
==SOX4==
 
{{medline-entry
|title=Age-induced accumulation of methylmalonic acid promotes tumour progression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814897
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* Cell Line, Tumor
* Disease Progression
* Female
* Gene Expression Regulation, Neoplastic
* Humans
* Male
* Methylmalonic Acid
* Mice
* Middle Aged
* Neoplasm Invasiveness
* Neoplasm Metastasis
* Neoplasms
* SOXC Transcription Factors
* Signal Transduction
* Transcriptome
* Transforming Growth Factor beta
 
|full-text-url=https://sci-hub.do/10.1038/s41586-020-2630-0
}}
==SOX9==
 
{{medline-entry
|title=Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32067417
 
|mesh-terms=* Adolescent
* Aged
* Aging
* Animals
* Arthroplasty, Replacement, Knee
* Bone Morphogenetic Proteins
* Cartilage, Articular
* Cell Proliferation
* Chondrocytes
* Collagen Type II
* Collagen Type X
* Core Binding Factor Alpha 1 Subunit
* Extracellular Matrix
* Female
* Growth Differentiation Factors
* Humans
* In Vitro Techniques
* Knee Joint
* Male
* Matrix Metalloproteinase 13
* Mice
* Osteoarthritis, Knee
* Parabiosis
* Phosphorylation
* RNA, Messenger
* Reverse Transcriptase Polymerase Chain Reaction
* SOX9 Transcription Factor
* Smad2 Protein
* Smad3 Protein
* Stifle
* Young Adult
 
|full-text-url=https://sci-hub.do/10.1002/art.41230
}}
==SPARC==
 
{{medline-entry
|title=[[SPARC]] Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32587523
 
 
|keywords=* aging
* falls
* functional mobility
* movement smoothness
* oldest-old
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298141
}}
{{medline-entry
|title=Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine ([[SPARC]])-null mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31582603
 
|mesh-terms=* Aging
* Animals
* Fibrillar Collagens
* Gene Expression
* Male
* Mice
* Mice, Knockout
* Muscle, Skeletal
* Myofibrils
* Osteonectin
|keywords=* Secreted protein acidic and rich in cysteine
* collagen
* fibrosis
* myofiber
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895640
}}
==SPR==
 
{{medline-entry
|title=Regulation of lifespan by neural excitation and REST.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31619788
 
|mesh-terms=* Aging
* Animals
* Brain
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* DNA-Binding Proteins
* Forkhead Transcription Factors
* Humans
* Longevity
* Mice
* Mice, 129 Strain
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
* Neurons
* RNA Interference
* RNA-Binding Proteins
* Repressor Proteins
* Transcription Factors
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893853
}}
==SPRTN==
 
{{medline-entry
|title=Tandem Deubiquitination and Acetylation of [[SPRTN]] Promotes DNA-Protein Crosslink Repair and Protects against Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32649882
 
|mesh-terms=* Acetylation
* Aging
* Animals
* Cell Line
* DNA Damage
* DNA Repair
* DNA-Binding Proteins
* Deubiquitinating Enzymes
* Endopeptidases
* Female
* Genomic Instability
* HEK293 Cells
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Knockout
* Phosphorylation
* Protein Domains
* Protein Processing, Post-Translational
* Ubiquitination
|keywords=* DNA repair
* DNA-protein crosslink
* SPRTN
* Top1cc
* VCPIP1/VCIP135
* acetylation
* aging
* genomic instability
* metalloprotease
* ubiquitination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484104
}}
==SPRY1==
 
{{medline-entry
|title=Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32304210
 
 
|keywords=* Adipogenesis
* Adipose stem cell
* Obesity
* Senescence
* Sprouty1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662188
}}
{{medline-entry
|title=Mechanism of [[SPRY1]] methylation regulating natural aging of skin epidermal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31483543
 
 
|keywords=* SPRY1
* methylation
* natural aging
* skin epidermal aging
|full-text-url=https://sci-hub.do/10.1111/jocd.13126
}}
==SQSTM1==
 
{{medline-entry
|title=The selective autophagy receptor [[SQSTM1]]/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041473
 
 
|keywords=* Aging
* C. elegans
* Drosophila
* SQST-1
* SQSTM1
* aggrephagy
* heat shock
* mitophagy
* p62
* proteostasis
* ref(2)P
* selective autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138197
}}
==SRC==
 
{{medline-entry
|title=Metabolic characteristics of CD8  T cell subsets in young and aged individuals are not predictive of functionality.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504069
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* CD8-Positive T-Lymphocytes
* Cell Differentiation
* Cell Proliferation
* Disease Models, Animal
* Female
* Humans
* Immunologic Memory
* Influenza A virus
* Influenza, Human
* Male
* Mice
* Microscopy, Electron, Transmission
* Mitochondria
* T-Lymphocyte Subsets
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275080
}}
==SRD5A2==
 
{{medline-entry
|title=Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125089
 
 
|keywords=*
P zeylanica
 
* 5α-reductase
* dermal papilla
* hair
* plumbagin
* senescence
|full-text-url=https://sci-hub.do/10.1111/jocd.13355
}}
==SRF==
 
{{medline-entry
|title=Changes in snail and [[SRF]] expression in the kidneys of diabetic rats during ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31668740
 
|mesh-terms=* Aging
* Animals
* Diabetes Mellitus, Experimental
* Diabetic Nephropathies
* Gene Expression Regulation
* Kidney
* Male
* Rats
* Rats, Sprague-Dawley
* Snail Family Transcription Factors
* Transcription Factors
|keywords=* Diabetic nephropathy
* Renal fibrosis
* SRF
* Snail
|full-text-url=https://sci-hub.do/10.1016/j.acthis.2019.151460
}}
{{medline-entry
|title=Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31638828
 
|mesh-terms=* Actins
* Adaptor Proteins, Signal Transducing
* Aging
* Biomechanical Phenomena
* Cells, Cultured
* Cytoskeleton
* Gene Expression Regulation
* Humans
* Hydrogels
* Intervertebral Disc Degeneration
* Nucleus Pulposus
* RNA Interference
* Trans-Activators
* Transcription Factors
* rho-Associated Kinases
|keywords=* F-actin
* SRF
* TEAD
* intervertebral disc
* mechanotransduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894097
}}
==SRL==
 
{{medline-entry
|title=Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32432936
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Cohort Studies
* Female
* Humans
* Income
* Indians, South American
* Longevity
* Male
* Middle Aged
* North Carolina
* Social Class
* Surveys and Questionnaires
* Survival Analysis
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250001
}}
==SRM==
 
{{medline-entry
|title=[Geriatric specificities of localized renal cell carcinoma].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771769
 
|mesh-terms=* Age Factors
* Aged
* Carcinoma, Renal Cell
* Geriatric Assessment
* Humans
* Kidney Neoplasms
|keywords=* Cancer du rein
* Diagnosis
* Diagnostic
* Elderly
* Geriatrics
* Gériatrie
* Personne âgée
* Petite masse rénale
* Renal cell carcinoma
* Small renal mass
* Traitement
* Treatment
|full-text-url=https://sci-hub.do/10.1016/j.purol.2019.08.281
}}
==SSB==
 
{{medline-entry
|title=Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816850
 
|mesh-terms=* Adolescent
* Adolescent Nutritional Physiological Phenomena
* Aging
* Humans
* Models, Biological
* Obesity
* Odds Ratio
* Risk Factors
* Sugar-Sweetened Beverages
* Young Adult
|keywords=* obesity
* substitution modelling
* sugar-sweetened beverages
* waist circumference
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950484
}}
==SST==
 
{{medline-entry
|title=The distance to death perceptions of older adults explain why they age in place: A theoretical examination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32972627
 
 
|keywords=* Agency- or belonging-related
* Distance to death, aging in place
* Emotions
* Residential mobility
* Socioemotional selectivity theory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489887
}}
{{medline-entry
|title=Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32607929
 
 
|keywords=* aging
* health services research
* psychometrics
|full-text-url=https://sci-hub.do/10.1007/s11606-020-05962-4
}}
{{medline-entry
|title=Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158369
 
 
|keywords=* Aging
* Emotion regulation
* Future time perspective
* Socioemotional selectivity theory
* Time left in life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040126
}}
==STAT1==
 
{{medline-entry
|title=[[STAT1]]-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32953802
 
 
|keywords=* Adriamycin
* STAT1
* chronic nephrosis (CN)
* mitogen-activated protein kinase
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475511
}}
{{medline-entry
|title=Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906225
 
|mesh-terms=* Adipose Tissue
* Aging
* Animals
* Carotid Arteries
* Carotid Artery Diseases
* Carotid Artery Injuries
* Humans
* Mice
* Mice, Mutant Strains
* Neointima
* Paracrine Communication
* STAT1 Transcription Factor
|keywords=* aging
* atherosclerosis
* neointima formation
* perivascular adipose tissue
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981748
}}
{{medline-entry
|title=Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/[[STAT1]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31857155
 
|mesh-terms=* Animals
* Bone Marrow Transplantation
* Breast Neoplasms
* Cell Cycle Proteins
* Cell Line, Tumor
* Cellular Senescence
* Disease Models, Animal
* Female
* Gene Expression Regulation, Neoplastic
* Humans
* Integrin alphaVbeta3
* Interleukin-1beta
* Janus Kinase 1
* Macrophage Activation
* Macrophages
* Mice
* Mice, Knockout
* STAT1 Transcription Factor
* Signal Transduction
|keywords=* Cellular senescence
* Legumain
* M1 polarization
* Tumor-associated macrophage
|full-text-url=https://sci-hub.do/10.1016/j.canlet.2019.12.013
}}
==STAT3==
 
{{medline-entry
|title=Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083279
 
 
|keywords=* Cyclin D1
* NF-κB
* STAT3
* Senescence
* p62/SQSTM1
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548900
}}
{{medline-entry
|title=Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33045434
 
 
|keywords=* Aging
* Appetite
* Glucocorticoid
* Leptin
* Obesity
* Osteoblast
* Osteocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596342
}}
{{medline-entry
|title=AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/[[STAT3]] axis-mediated positive feedback loop.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882228
 
 
|keywords=* AMPK
* NF-κB/STAT3 signalling
* Oxidative stress
* SASP
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111347
}}
{{medline-entry
|title=Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through [[STAT3]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848054
 
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Cell Proliferation
* Computational Biology
* Gene Expression Regulation
* Glucosamine
* Hippocampus
* Mice
* Neural Stem Cells
* Neurogenesis
* Neuroglia
* STAT3 Transcription Factor
* Sequence Analysis, RNA
|keywords=* O-GlcNAcylation
* aging
* gliogenesis
* neural stem cells
* neurogenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730
}}
{{medline-entry
|title=Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32714471
 
 
|keywords=* Apoptosis
* JAK/STAT
* caspase
* colon cancer
* gallotannin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378856
}}
{{medline-entry
|title=The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693349
 
 
|keywords=* Aging
* For review: bacterial lipolisacharide (LPS)
* Heart
* Inflammation
* Interleukin-6
* Signal transduction
|full-text-url=https://sci-hub.do/10.1016/j.advms.2020.06.006
}}
{{medline-entry
|title=Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517353
 
 
|keywords=* IL-6
* JAK
* coronavirus
* cytokine storm
* remdesivir
* senescence
* stat3
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356916
}}
{{medline-entry
|title=Implication of JAK1/[[STAT3]]/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483368
 
|mesh-terms=* Aging
* Animals
* Caspase 3
* Cerebellum
* Glial Fibrillary Acidic Protein
* Glutathione
* Immunohistochemistry
* Janus Kinase 1
* Male
* Malondialdehyde
* Microscopy, Electron
* Rats
* Rats, Wistar
* STAT3 Transcription Factor
* Signal Transduction
* Suppressor of Cytokine Signaling 3 Protein
* Tumor Necrosis Factor-alpha
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264275
}}
{{medline-entry
|title=Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/[[STAT3]] pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32257389
 
 
|keywords=* Cancer therapy
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105491
}}
{{medline-entry
|title=Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012719
 
 
|keywords=* aging biomarkers
* cancer biology
* cellular senescence
* epithelial ovarian cancer
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072138
}}
{{medline-entry
|title=Persistent Activation of [[STAT3]] Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884637
 
|mesh-terms=* Aging
* Animals
* Mice
* Mice, Inbred C57BL
* Retina
* Retinal Degeneration
* STAT3 Transcription Factor
* Suppressor of Cytokine Signaling 3 Protein
* Suppressor of Cytokine Signaling Proteins
* Uveitis
|keywords=* EAU
* Experimental autoimmune uveitis
* Retinal dystrophies
* SOCS3
* STAT3
* Transgenic mouse
* Uveitis
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_58
}}
{{medline-entry
|title=Interleukin-10 induces senescence of activated hepatic stellate cells via [[STAT3]]-p53 pathway to attenuate liver fibrosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730896
 
 
|keywords=* Hepatic stellate cells
* Interleukin-10
* Liver fibrosis
* Senescence
* Signal pathway
|full-text-url=https://sci-hub.do/10.1016/j.cellsig.2019.109445
}}
==STC2==
 
{{medline-entry
|title=Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and [[STC2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31761296
 
|mesh-terms=* Adult
* Aged
* Aging
* Animals
* Body Composition
* Body Weight
* Calcium-Binding Proteins
* Case-Control Studies
* Female
* Follow-Up Studies
* Genome-Wide Association Study
* Glycoproteins
* Humans
* Intercellular Signaling Peptides and Proteins
* Male
* Mice
* Middle Aged
* Muscle Development
* Muscle, Skeletal
* Quantitative Trait Loci
* Thinness
|keywords=* UK Biobank
* human and mouse GWAS
* sarcopenia
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904802
}}
==STIM1==
 
{{medline-entry
|title=Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31833196
 
|mesh-terms=* Animals
* Calcium
* Calnexin
* Cell Nucleus
* Disease Models, Animal
* Endoplasmic Reticulum
* Endoplasmic Reticulum Stress
* Lamin Type A
* Mice
* Mice, Knockout
* Microscopy, Electron, Transmission
* Muscle Proteins
* Muscle, Skeletal
* Muscular Dystrophies
* Mutation
* Myoblasts
* ORAI1 Protein
* Progeria
* Proteolipids
* Stromal Interaction Molecule 1
* Thermogenesis
* Up-Regulation
|keywords=* aging
* calcium homeostasis
* lamin A
* muscular dystrophy
* progeria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996945
}}
==STS==
 
{{medline-entry
|title=Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33192547
 
 
|keywords=* aging
* balance
* falls
* fatigue
* functional performance
* muscle damage
* walking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609421
}}
{{medline-entry
|title=Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33022071
 
 
|keywords=* autophagy
* caspase
* cell death
* remodeling
* senescence
|full-text-url=https://sci-hub.do/10.1002/jcp.30079
}}
{{medline-entry
|title=The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32080737
 
 
|keywords=* Chinese wild grape (Vitis quinquangularis)
* WRKY transcription factor
* disease resistance
* leaf senescence
* stilbene
* transcriptional regulation
|full-text-url=https://sci-hub.do/10.1093/jxb/eraa097
}}
{{medline-entry
|title=On the role of ageing and musculoskeletal pain on dynamic balance in manual workers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733466
 
|mesh-terms=* Aged
* Aging
* Female
* Humans
* Male
* Middle Aged
* Muscle, Skeletal
* Musculoskeletal Pain
* Occupational Diseases
* Postural Balance
|keywords=* Discomfort
* Lower extremity function
* Posturography
* Sit-to-stand
|full-text-url=https://sci-hub.do/10.1016/j.jelekin.2019.102374
}}
==SUCNR1==
 
{{medline-entry
|title=[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105271
 
|mesh-terms=* Age Factors
* Aging
* Animals
* Male
* Mitochondria
* Neurodegenerative Diseases
* Picolines
* Rats
* Receptors, G-Protein-Coupled
* Transcription Factors
|keywords=* Western blot analysis
* aging
* cerebral mitochondriogenesis
* mexidol
* mitochondrial dysfunction
* rats
* respiratory enzyme subunits
* succinate receptor
* transcriptional coactivator PGC-1α
|full-text-url=https://sci-hub.do/10.17116/jnevro202012001162
}}
==SUGCT==
 
{{medline-entry
|title=Knockout of the non-essential gene [[SUGCT]] creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722069
 
|mesh-terms=* Aging
* Animals
* Anti-Bacterial Agents
* Bacteria
* Carnitine
* Coenzyme A-Transferases
* Dietary Supplements
* Feces
* Gastrointestinal Microbiome
* Humans
* Kidney
* Lipid Metabolism
* Liver
* Lysine
* Metabolic Syndrome
* Metabolome
* Mice
* Mice, Knockout
* Obesity
* Tryptophan
|keywords=* C7orf10
* Glutaric aciduria type 3 (GA3)
* Gut microflora
* Lipids
* Metabolomics
* Obesity
* Sugct
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426296
}}
==SUV39H1==
 
{{medline-entry
|title=Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31760560
 
 
|keywords=* Aging
* H3K9me3
* Hippocampus
* IEGs
* Memory
* SUV39H1
|full-text-url=https://sci-hub.do/10.1007/s10522-019-09850-1
}}
==SYK==
 
{{medline-entry
|title=miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/[[SYK]]/VEGFR-2 downregulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33201836
 
 
|keywords=* TULA-2
* aging
* angiogenesis
* endothelial cell
* miR-25-3p
|full-text-url=https://sci-hub.do/10.18632/aging.103834
}}
{{medline-entry
|title=Identification of [[SYK]] inhibitor, R406 as a novel senolytic agent.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32379705
 
 
|keywords=* FAK
* apoptosis
* cellular senescence
* p38
* senolytics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244031
}}
==SYNE1==
 
{{medline-entry
|title=Nesprin-1 impact on tumorigenic cell phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31741263
 
|mesh-terms=* Actins
* Carcinogenesis
* Cell Line, Tumor
* Cell Nucleus
* Cytoskeletal Proteins
* Gene Expression
* Gene Expression Regulation, Neoplastic
* Humans
* Microfilament Proteins
* Nerve Tissue Proteins
* Nuclear Envelope
* Phenotype
|keywords=* Cancer
* Cellular senescence
* Genome stability
* Nesprin-1
* Nuclear envelope
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05184-w
}}
==TAAR1==
 
{{medline-entry
|title=Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 ([[TAAR1]]) Knockout Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31399838
 
|mesh-terms=* Age Factors
* Animals
* Anxiety
* Dose-Response Relationship, Drug
* Male
* Mice
* Mice, 129 Strain
* Mice, Inbred C57BL
* Mice, Knockout
* Receptors, G-Protein-Coupled
* Sodium Chloride
|keywords=* Aging
* Anxiety
* Hematology
* Leukocytes
* Neutrophils
* TAAR1
* Thyroid
* Trace amines
|full-text-url=https://sci-hub.do/10.1007/s10571-019-00721-4
}}
==TAS2R16==
 
{{medline-entry
|title=Taste receptor polymorphisms and longevity: a systematic review and meta-analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33170488
 
 
|keywords=* Immune-inflammatory responses
* Longevity
* Meta-analysis
* Taste receptors
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01745-3
}}
==TAS2R38==
 
{{medline-entry
|title=[[TAS2R38]] bitter taste receptor and attainment of exceptional longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792278
 
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Case-Control Studies
* Female
* Food Preferences
* Gene Frequency
* Genetic Variation
* Haplotypes
* Humans
* Longevity
* Male
* Middle Aged
* Receptors, G-Protein-Coupled
* Taste
* Taste Perception
* Young Adult
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889489
}}
==TAZ==
 
{{medline-entry
|title=Transcriptional Coactivator [[TAZ]] Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31936650
 
 
|keywords=* TAZ
* cellular senescence
* oncogene
* p300
* p53
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016652
}}
==TBC1D5==
 
{{medline-entry
|title=[[TBC1D5]]-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521275
 
 
|keywords=* HPV
* Rab7B
* TBC1D5
* functional genetics screen
* proximity ligation assay
* retrograde
* retromer
* senescence
* traptamer
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339955
}}
{{medline-entry
|title=Retromer and [[TBC1D5]] maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31431476
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Longevity
* Mechanistic Target of Rapamycin Complex 1
* Membrane Microdomains
* Signal Transduction
* rab GTP-Binding Proteins
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719456
}}
==TBK1==
 
{{medline-entry
|title=Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of [[TBK1]] to facilitate mitophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33164878
 
 
|keywords=* Aging
* K63-linked polyubiquitination
* Mitophagy
* Parkin
* TBK1
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165997
}}
==TCF7L2==
 
{{medline-entry
|title=A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32015540
 
|mesh-terms=* Aging
* Animals
* Autism Spectrum Disorder
* Cell Count
* DNA Fingerprinting
* Facies
* Gene Expression Regulation
* Humans
* Hyperventilation
* Intellectual Disability
* Methyl-CpG-Binding Protein 2
* Mice
* Mice, Knockout
* Myelin Sheath
* Oligodendroglia
* PTEN Phosphohydrolase
* Primary Cell Culture
* Signal Transduction
* Transcription Factor 4
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065955
}}
==TEC==
 
{{medline-entry
|title=Vestibular function and cortical and sub-cortical alterations in an aging population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904672
 
 
|keywords=* Aging
* Cognition
* Diffeomorphometry
* Epidemiology
* Eye-ear-nose-throat
* MRI
* Medical imaging
* Shape
* Vestibular
* Volume
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457317
}}
{{medline-entry
|title=Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32733450
 
 
|keywords=* cell death
* innate immunity
* kidney transplantation
* mitochondria
* senescence
* tubular repair
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358591
}}
{{medline-entry
|title=Postnatal Involution and Counter-Involution of the Thymus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477366
 
 
|keywords=* Myc
* aging
* cyclin D1
* growth
* involution
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235445
}}
{{medline-entry
|title=Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194555
 
 
|keywords=* aging
* chemotherapy
* gender
* luteinizing hormone-releasing hormone
* regeneration
* sex hormone deprivation
* thymic epithelial cell
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062683
}}
{{medline-entry
|title=Clonogenic Culture of Mouse Thymic Epithelial Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396938
 
|mesh-terms=* Aging
* Animals
* Cell Differentiation
* Cell Line
* Coculture Techniques
* Colony-Forming Units Assay
* DNA-Binding Proteins
* Epithelial Cells
* Flow Cytometry
* Fluorescent Antibody Technique, Direct
* Fluorescent Dyes
* Immunomagnetic Separation
* Mice
* Mice, Knockout
* Primary Cell Culture
* Rhodamines
* Self Tolerance
* Staining and Labeling
* Stem Cells
* Thymus Gland
|keywords=* Clonogenic assay
* Thymic epithelial cells
* Thymic epithelial stem cells
* Thymus
|full-text-url=https://sci-hub.do/10.1007/978-1-4939-9728-2_15
}}
==TEF==
 
{{medline-entry
|title=Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32189112
 
 
|keywords=* Aging
* Cancer
* HSP27
* Hormesis
* Neurodegeneratve diseases
* Proteasome
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09869-9
}}
==TERT==
 
{{medline-entry
|title=Telomeres and telomerase in risk assessment of cardiovascular diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171154
 
 
|keywords=* Cardiovascular diseases
* Senescence
* Telomerase
* Telomeres
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112361
}}
{{medline-entry
|title=A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33046533
 
 
|keywords=* RNA
* RNP
* TERT
* TLC1
* senescence
* telomerase
* telomerase RNA
* telomere
* two-hybrid screening
* yeast
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685517
}}
{{medline-entry
|title=Angiotensin inhibition and cellular senescence in the developing rat kidney.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010296
 
 
|keywords=* Apoptosis
* Cellular senescence
* Fetal development
* Kidney
* Renin-angiotensin system
|full-text-url=https://sci-hub.do/10.1016/j.yexmp.2020.104551
}}
{{medline-entry
|title=Decreased expression of [[TERT]] and telomeric proteins as human ovaries age may cause telomere shortening.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856217
 
 
|keywords=* Ovarian aging
* TERT
* Telomere
* Telomere-binding proteins
|full-text-url=https://sci-hub.do/10.1007/s10815-020-01932-1
}}
{{medline-entry
|title=The secrets of telomerase: Retrospective analysis and future prospects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32698073
 
|mesh-terms=* Aging
* Animals
* Diabetes Mellitus
* Humans
* Neoplasms
* Telomerase
* Telomere Shortening
|keywords=* Cancers
* G-quadruplex formation
* Metabolic disorders
* TERT gene
* Telomere-telomerase system
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118115
}}
{{medline-entry
|title=Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399807
 
 
|keywords=* Cell aging
* Genes
* Human mesenchymal stem cells
* Short peptides
|full-text-url=https://sci-hub.do/10.1007/s11033-020-05506-3
}}
{{medline-entry
|title=Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32244882
 
 
|keywords=* cellular mechanisms
* gene expression
* nutraceuticals
* oxidative stress
* senescence
* stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150900
}}
{{medline-entry
|title=Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32114208
 
|mesh-terms=* Adult
* Aging
* Antimanic Agents
* Bipolar Disorder
* Cellular Senescence
* Female
* Humans
* Lithium
* Lithium Compounds
* Male
* Middle Aged
* Mitochondria
* Oxidative Stress
* Polymorphism, Single Nucleotide
* Real-Time Polymerase Chain Reaction
* Telomerase
* Telomere
* Telomere Homeostasis
* Telomere Shortening
|keywords=* Affective disorder
* Aging
* Mitochondria
* Oxidative stress
* TERT
* Telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334059
}}
{{medline-entry
|title=FAM96B inhibits the senescence of dental pulp stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039527
 
 
|keywords=* FAM96B
* aging
* dental pulp stem cells (DPSCs)
* proteomic analysis
|full-text-url=https://sci-hub.do/10.1002/cbin.11319
}}
{{medline-entry
|title=Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061643
 
 
|keywords=* Aging
* Long non-coding RNA
* Osteopontin
* Telomeres
* miRNA
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110879
}}
{{medline-entry
|title=Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978617
 
 
|keywords=* Adipogenesis
* Antioxidant
* Bone marrow adiposity
* Bone marrow skeletal stromal cells
* Cellular senescence
* Osteogenesis
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115252
}}
{{medline-entry
|title=Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948601
 
|mesh-terms=* Adolescent
* Aged
* Anterior Cruciate Ligament
* Cell Differentiation
* Cell Separation
* Cells, Cultured
* Humans
* Mesenchymal Stem Cells
* Telomerase
|keywords=* Anterior cruciate ligament
* Immortalization
* Mesenchymal stem cells
* Multilineage differentiation
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962762
}}
{{medline-entry
|title=Mitochondria, Telomeres and Telomerase Subunits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781563
 
 
|keywords=* TERC
* TERT
* aging
* mitochondria
* telomerase
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851022
}}
{{medline-entry
|title=Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717801
 
|mesh-terms=* Animals
* Antioxidants
* Behavior, Animal
* Brain Chemistry
* Euterpe
* Fruit and Vegetable Juices
* Lipid Peroxidation
* Male
* Mercury
* Mice
* Motor Skills
* Neurotoxins
* Plant Extracts
* Telomere
|keywords=* Euterpe
* acai
* aging
* antioxidant
* açaí
* extract
* intoxication
* methylmercury
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893510
}}
{{medline-entry
|title=Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31597307
 
|mesh-terms=* Aging
* Animals
* Cellular Senescence
* DNA Damage
* DNA Replication
* DNA, Mitochondrial
* Epigenesis, Genetic
* Humans
* Mitochondria
* Oxidative Stress
* Stress, Physiological
* Telomere
* Telomere Homeostasis
* Telomere Shortening
|keywords=* G-quadruplex
* R-loop
* ageing
* helicase
* mitochondria
* replication stress
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801922
}}
{{medline-entry
|title=Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544708
 
 
|keywords=* Aging
* TERT
* associates
* cancer
* cell cycle
* diseases
* oncogenes
* viral infection.
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403649
}}
{{medline-entry
|title=Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481614
 
|mesh-terms=* Animals
* Cell Cycle
* Cell Transformation, Neoplastic
* Cells, Cultured
* Cellular Senescence
* Fibroblasts
* Gene Expression
* Gene Expression Regulation
* Gene Knockdown Techniques
* Humans
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Phenotype
* Telomerase
* Telomere
|keywords=* ATM
* senescence
* telomerase
* tumorigenesis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754593
}}
==TET2==
 
{{medline-entry
|title=Non-coding and Loss-of-Function Coding Variants in [[TET2]] are Associated with Multiple Neurodegenerative Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330418
 
|mesh-terms=* Aged
* Aged, 80 and over
* Alzheimer Disease
* Animals
* Cognition
* DNA-Binding Proteins
* Female
* Frontotemporal Dementia
* Humans
* Loss of Function Mutation
* Male
* Mice
* Neurodegenerative Diseases
* Proto-Oncogene Proteins
|keywords=* AD
* ALS
* Alzheimer
* FTD
* TET2
* aging
* amyotrophic lateral sclerosis
* frontotemporal dementia
* genome sequencing
* non-coding
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212268
}}
{{medline-entry
|title=60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001340
 
|mesh-terms=* Adult
* Aging
* Biomedical Research
* Chromosomes, Human, X
* DNA-Binding Proteins
* Female
* Hematopoiesis
* Hematopoietic Stem Cells
* History, 20th Century
* History, 21st Century
* Humans
* Male
* Mutation
* Proto-Oncogene Proteins
* Receptors, Androgen
* Repressor Proteins
* X Chromosome Inactivation
 
|full-text-url=https://sci-hub.do/10.1016/j.exphem.2020.01.008
}}
{{medline-entry
|title=DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31842975
 
|mesh-terms=* Animals
* Caco-2 Cells
* Cell Line, Tumor
* Colonic Neoplasms
* DNA Methylation
* DNA-Binding Proteins
* Down-Regulation
* Epigenesis, Genetic
* Female
* Gene Regulatory Networks
* HT29 Cells
* Humans
* Male
* Mice
* Mixed Function Oxygenases
* Mutation
* Neoplasms, Experimental
* Proto-Oncogene Proteins
* Proto-Oncogene Proteins B-raf
|keywords=* Aging
* BRAF V600E
* CIMP
* Colon cancer
* DNA methylation
* TET
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916434
}}
{{medline-entry
|title=Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31406340
 
|mesh-terms=* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Animals
* Cardiovascular Diseases
* DNA (Cytosine-5-)-Methyltransferases
* DNA-Binding Proteins
* Genetic Predisposition to Disease
* Hematopoiesis
* Hematopoietic Stem Cells
* Humans
* Inflammation
* Middle Aged
* Mutation
* Phenotype
* Proto-Oncogene Proteins
* Repressor Proteins
* Risk Assessment
* Risk Factors
 
|full-text-url=https://sci-hub.do/10.1038/s41569-019-0247-5
}}
==TF==
 
{{medline-entry
|title=A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736289
 
 
|keywords=* Aging
* Beef
* Collagen
* Tenderness
* Trained panel
|full-text-url=https://sci-hub.do/10.1016/j.meatsci.2020.108247
}}
{{medline-entry
|title=The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430911
 
 
|keywords=* ZmNAC
* chlorophyll catabolic genes
* ethylene
* leaf senescence
* maize
|full-text-url=https://sci-hub.do/10.1111/pce.13803
}}
{{medline-entry
|title=Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32313054
 
|mesh-terms=* Aging
* Gene Expression Profiling
* Gene Expression Regulation, Plant
* Genome, Plant
* Photosynthesis
* Plant Leaves
* Populus
* Seasons
* Transcription Factors
* Transcriptome
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170949
}}
{{medline-entry
|title=Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32174770
 
 
|keywords=* Japanese quail
* albumin
* sperm longevity
* sperm storage tubules
* transferrin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063080
}}
{{medline-entry
|title=OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31505875
 
|mesh-terms=* Abscisic Acid
* Chlorophyll
* Gene Expression Regulation, Plant
* Gene Knockdown Techniques
* Oryza
* Plant Leaves
* Plant Proteins
* Transcription Factors
|keywords=* NAC
* OsWRKY
* abscisic acid (ABA)
* leaf senescence
* rice
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770167
}}
{{medline-entry
|title=BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31416297
 
|mesh-terms=* Amino Acid Sequence
* Brassica
* Cellular Senescence
* Cyclopentanes
* Gene Expression Regulation, Plant
* Oxylipins
* Phenotype
* Phylogeny
* Plant Growth Regulators
* Plant Leaves
* Plant Proteins
* Promoter Regions, Genetic
* Protein Binding
* Transcription Factors
|keywords=* Chinese flowering cabbage
* JA
* leaf senescence
* transcriptional activation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719003
}}
{{medline-entry
|title=Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398806
 
|mesh-terms=* Aging
* Base Sequence
* Brassica
* Food Preservation
* Gene Expression Regulation, Plant
* Gibberellins
* Phenotype
* Phylogeny
* Plant Leaves
* Plant Proteins
* Promoter Regions, Genetic
* Protein Binding
* Transcription Factors
|keywords=* Chinese flowering cabbage
* GA
* leaf senescence
* transcriptional activation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720506
}}
==TFEB==
 
{{medline-entry
|title=A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33144423
 
 
|keywords=* Senescence
* autophagy
* glycolysis
* hypoxia
* lipofuscin
* lung cancer
|full-text-url=https://sci-hub.do/10.21873/invivo.12154
}}
{{medline-entry
|title=ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32440476
 
 
|keywords=* embryonic stem cells derived small extracellular vesicles (ESC‐sEVs)
* hippocampal neural stem cells (HNSCs)
* lysosomes
* senescence
* vascular dementia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237844
}}
{{medline-entry
|title=Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047576
 
|mesh-terms=* Aging
* Animals
* Autophagy
* Cells, Cultured
* Homocysteine
* Humans
* Hyperhomocysteinemia
* Kidney
* Kidney Diseases
* Male
* Metalloporphyrins
* Peroxynitrous Acid
* Rats
* Rats, Sprague-Dawley
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007752
}}
{{medline-entry
|title=Polyamines reverse immune senescence via the translational control of autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31679458
 
|mesh-terms=* Aging
* Animals
* Autophagy
* Humans
* Lysosomes
* Polyamines
* Protein Processing, Post-Translational
* Spermidine
|keywords=* Aging
* B cells
* EIF5A
* TFEB
* autophagy
* hypusine
* spermidine
* translation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984486
}}
{{medline-entry
|title=Polyamines Control eIF5A Hypusination, [[TFEB]] Translation, and Autophagy to Reverse B Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31474573
 
|mesh-terms=* Adaptive Immunity
* Age Factors
* Aging
* Animals
* Autophagy
* B-Lymphocytes
* Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
* Cellular Senescence
* HEK293 Cells
* Humans
* Immunologic Memory
* Immunosenescence
* Jurkat Cells
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* NIH 3T3 Cells
* Peptide Initiation Factors
* Protein Processing, Post-Translational
* RNA-Binding Proteins
* Signal Transduction
* Spermidine
|keywords=* B cell
* TFEB
* aging
* autophagy
* eIF5A
* spermidine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863385
}}
==TFPI==
 
{{medline-entry
|title=Identification of cardiovascular health gene variants related to longevity in a Chinese population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32897244
 
 
|keywords=* Chinese
* factor related to cardiovascular health (FCH)
* genetic variation
* lipid metabolism
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521493
}}
==TG==
 
{{medline-entry
|title=Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33126043
 
 
|keywords=* Budding yeast
* Rad52
* Replicative senescence
* Subtelomeric Y’ elements
* Telomerase-independent telomere maintenance
* Telomere recombination
|full-text-url=https://sci-hub.do/10.1016/j.dnarep.2020.102996
}}
{{medline-entry
|title=E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102865
 
 
|keywords=* Aging
* CKD
* Diabetes
* Diet
* E4orf1
* FA synthesis
* Hyperinsulinemia
* Insulin
* Lipid metabolism
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575883
}}
{{medline-entry
|title=Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33032071
 
 
|keywords=* Aging
* Cardiometabolic
* Lipemia
* Metabolism
* Nutrition
|full-text-url=https://sci-hub.do/10.1016/j.nutres.2020.08.012
}}
{{medline-entry
|title=Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32936538
 
 
|keywords=* PPARα
* RAGE
* aging
* hepatic steatosis
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576254
}}
{{medline-entry
|title=Fenofibrate impairs liver function and structure more pronounced in old than young rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927318
 
 
|keywords=* Aging
* Fenofibrate
* Lipids
* Liver function and morphology
* Rat
* serum
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104244
}}
{{medline-entry
|title=Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249143
 
|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Blood Glucose
* Blood Pressure
* Cardiovascular Diseases
* Cholesterol
* Cross-Sectional Studies
* Diabetes Mellitus
* Female
* Humans
* Hypercholesterolemia
* Hypertension
* Hypertriglyceridemia
* Italy
* Male
* Middle Aged
* Risk Assessment
* Risk Factors
* Triglycerides
* Vascular Stiffness
* Young Adult
|keywords=* Arterial aging
* Awareness
* Epidemiology
* Pulse wave velocity
* Risk factors
|full-text-url=https://sci-hub.do/10.1016/j.numecd.2020.03.005
}}
{{medline-entry
|title=Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221338
 
|mesh-terms=* Aging
* Animals
* Daphnia
* Diglycerides
* Female
* Lipid Metabolism
* Longevity
* Male
* Phosphatidylcholines
* Sphingomyelins
* Triglycerides
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101400
}}
{{medline-entry
|title=Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31472466
 
|mesh-terms=* Benzopyrans
* Charcoal
* Humic Substances
* Microbiota
* Soil Microbiology
* Solubility
* Triticum
* Water
|keywords=* Biochar
* Biotic incubation aging
* Dissolved organic matter (DOM)
* Excitation-emission matrix
* Humification
|full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2019.121071
}}
{{medline-entry
|title=Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31403614
 
|mesh-terms=* Animals
* Caenorhabditis elegans
* Hazardous Substances
* Humans
* Longevity
* Reproduction
* Toxicity Tests
 
|full-text-url=https://sci-hub.do/10.3791/59367
}}
==TH==
 
{{medline-entry
|title=Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33219914
 
 
|keywords=* Aging
* Muscle mass
* Muscle strength
* Oldest-old
* Physical performance
* Rehabilitation
* Thyroid hormone signaling
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00302-0
}}
{{medline-entry
|title=Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32772235
 
 
|keywords=* Behavioral responses
* Immunosenescence
* Oxidative-inflammatory stress
* Social environmental strategy
* Tyrosine hydroxylase haploinsufficient mice
|full-text-url=https://sci-hub.do/10.1007/s11481-020-09947-2
}}
{{medline-entry
|title=Mechanism of thyroid hormone signaling in skeletal muscle of aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32720201
 
 
|keywords=* Aging
* Mice
* Skeletal muscle
* Thyroid hormone signaling
|full-text-url=https://sci-hub.do/10.1007/s12020-020-02428-9
}}
{{medline-entry
|title=Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32621253
 
|mesh-terms=* Absorptiometry, Photon
* Adult
* Bone Density
* Cancellous Bone
* Cohort Studies
* Female
* Humans
* Lumbar Vertebrae
* Male
* Prospective Studies
* Republic of Korea
|keywords=* Aging
* Bone mineral density
* Natural history
* Osteoporosis
|full-text-url=https://sci-hub.do/10.1007/s11657-020-00731-6
}}
{{medline-entry
|title=Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270889
 
 
|keywords=* RRID:AB_11145309
* RRID:AB_2109791
* RRID:AB_228307
* RRID:AB_228341
* RRID:AB_2336820
* RRID:AB_2631098
* RRID:AB_390204
* RRID:MGI:5651135
* RRID:SCR_001881
* RRID:SCR_002798
* RRID:SCR_003070
* RRID:SCR_004946
* RRID:SCR_005223
* aging
* dopaminergic neuron
* glial fibrillary acidic protein
* proteome
* proteomics
* substantia nigra
|full-text-url=https://sci-hub.do/10.1002/jnr.24622
}}
{{medline-entry
|title=Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31982873
 
|mesh-terms=* Aging
* Animals
* Brain
* Corpus Striatum
* Dopaminergic Neurons
* Male
* Motor Activity
* Neuroprotective Agents
* Rats
* Rats, Wistar
* Substantia Nigra
* Tyrosine 3-Monooxygenase
* Withanolides
|keywords=* Ageing
* Dopamine
* Striatum
* Substantia nigra
* Withaferin-A
|full-text-url=https://sci-hub.do/10.1159/000505183
}}
{{medline-entry
|title=Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655946
 
|mesh-terms=* Absorptiometry, Photon
* Aged
* Bone Density
* Cross-Sectional Studies
* Exercise
* Female
* Femur Neck
* Humans
* Lumbar Vertebrae
* Male
* Middle Aged
* Nutrition Surveys
* Osteoporosis
* Republic of Korea
* Surveys and Questionnaires
|keywords=* Aging
* Bone mineral density
* Exercise
* Gender
* Osteoporosis
* Physical activity
|full-text-url=https://sci-hub.do/10.1007/s11657-019-0655-5
}}
{{medline-entry
|title=Age-Related Resistance to Thyroid Hormone Action.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512083
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Animals
* Humans
* Hyperthyroidism
* Hypothyroidism
* Iodide Peroxidase
* Male
* Receptors, Thyroid Hormone
* Thyroid Hormones
* Thyroxine
* Triiodothyronine
 
|full-text-url=https://sci-hub.do/10.1007/s40266-019-00711-7
}}
{{medline-entry
|title=Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31504428
 
|mesh-terms=* Aging
* Animals
* Animals, Genetically Modified
* Glucose
* Glucose Transport Proteins, Facilitative
* Homeostasis
* Hyperglycemia
* Iodide Peroxidase
* Islets of Langerhans
* Male
* Proglucagon
* Proinsulin
* Receptor, Insulin
* Receptors, Glucagon
* Zebrafish
 
|full-text-url=https://sci-hub.do/10.1210/en.2019-00445
}}
{{medline-entry
|title=Age effect on thyroid hormone brain response in male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494803
 
|mesh-terms=* Aging
* Animals
* Brain
* Gene Expression
* Hyperthyroidism
* Hypothyroidism
* Male
* Maze Learning
* Mice, Inbred C57BL
* Monocarboxylic Acid Transporters
* Organic Cation Transport Proteins
* Rotarod Performance Test
* Symporters
* Thyroid Hormones
* Thyrotropin
* Thyrotropin-Releasing Hormone
|keywords=* Ageing
* Hyperthyroidism
* Hypothyroidism
* Male mice
* Thyroid hormones
|full-text-url=https://sci-hub.do/10.1007/s12020-019-02078-6
}}
{{medline-entry
|title=Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441387
 
|mesh-terms=* Aging
* Animals
* DNA-Binding Proteins
* Hypothalamo-Hypophyseal System
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Myocardium
* Pituitary Gland
* Thyroid Gland
* Thyroid Hormones
* Thyrotropin
* Thyroxine
* Transcription Factors
|keywords=* HPT-axis
* aging
* mice
* thyroid gland
* thyroid hormones
|full-text-url=https://sci-hub.do/10.1089/thy.2018.0377
}}
==TLR1==
 
{{medline-entry
|title=Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32969782
 
 
|keywords=* TLR
* aging
* innate immunity
* lifelong exercise
* skeletal muscle
|full-text-url=https://sci-hub.do/10.1152/japplphysiol.00615.2020
}}
{{medline-entry
|title=Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901560
 
|mesh-terms=* Age Factors
* Animals
* Breeding
* Cattle
* Czech Republic
* Female
* Genotype
* Longevity
* Male
* Phenotype
* Polymorphism, Single Nucleotide
* Reproduction
* Toll-Like Receptor 1
* Toll-Like Receptor 2
* Toll-Like Receptor 6
* Toll-Like Receptors
|keywords=* Cattle
* Diversity
* Effect prediction
* Health traits
* Toll-like receptors
|full-text-url=https://sci-hub.do/10.1016/j.vetimm.2019.109997
}}
==TLR2==
 
{{medline-entry
|title=Changes in salivary microbial sensing proteins CD14 and [[TLR2]] with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529494
 
|mesh-terms=* Adolescent
* Adult
* Aging
* Biomarkers
* Child
* Child, Preschool
* Humans
* Lipopolysaccharide Receptors
* Middle Aged
* Saliva
* Salivary Proteins and Peptides
* Toll-Like Receptor 2
* Young Adult
|keywords=* Age changes
* CD14
* Saliva
* Toll-like receptor-2
|full-text-url=https://sci-hub.do/10.1007/s00784-020-03274-9
}}
{{medline-entry
|title=Culture Model for Non-human Primate Choroid Plexus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555096
 
 
|keywords=* aging
* cell culture
* choroid plexus
* epithelial cell
* infectious disease
* rhesus macaque
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724611
}}
==TLR4==
 
{{medline-entry
|title=Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973755
 
 
|keywords=* adipokines
* aging
* batokines
* biglycan
* cytokines
* fat explant cultures
* high mobility group box-1 protein
* lipopolysaccharide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466552
}}
{{medline-entry
|title=Role of Toll Like Receptor 4 in Alzheimer's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983082
 
 
|keywords=* Alzheimer’s disease
* TLR4
* aging
* amyloid beta oligomers
* calcium
* hippocampal neurons
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479089
}}
{{medline-entry
|title=Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32718230
 
 
|keywords=* aging
* dissertations
* theses
|full-text-url=https://sci-hub.do/10.1089/rej.2020.2378
}}
{{medline-entry
|title=Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581723
 
 
|keywords=* aging
* desialylation
* galectin-3
* microglia
* neurodegeneration
* phagocytosis
* sialic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296093
}}
{{medline-entry
|title=Chemerin facilitates intervertebral disc degeneration via [[TLR4]] and CMKLR1 and activation of NF-kB signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526705
 
 
|keywords=* chemerin
* inflammation
* intervertebral disc
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343479
}}
{{medline-entry
|title=Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32343455
 
 
|keywords=* TLR4
* adult hippocampal neurogenesis
* aging
* proliferation
* sex differences
|full-text-url=https://sci-hub.do/10.1002/hipo.23209
}}
{{medline-entry
|title=Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31838133
 
|mesh-terms=* Animals
* B-Lymphocytes
* Cells, Cultured
* Immunity, Cellular
* Immunosenescence
* Male
* Malondialdehyde
* Oxidative Stress
* Rats
* Rats, Wistar
* Spleen
* Superoxide Dismutase
* T-Lymphocytes
|keywords=* Aging
* Immunohistochemistry
* Immunosenescence
* Oxidative stress
* Spleen
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117168
}}
{{medline-entry
|title=Leptin induces immunosenescence in human B cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831137
 
|mesh-terms=* Adult
* Aged
* B-Lymphocytes
* Humans
* Immunoglobulin Class Switching
* Immunosenescence
* Leptin
* Middle Aged
* Obesity
|keywords=* B cells
* Immunosenescence
* Leptin
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002206
}}
{{medline-entry
|title=Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547158
 
 
|keywords=* DTaP
* IgG subclass
* antibody longevity
* antibody magnitude
* genetics
* vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963843
}}
{{medline-entry
|title=Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the [[TLR4]]/MyD88/NF‑κB signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432123
 
|mesh-terms=* Aging
* Animals
* Autophagic Cell Death
* Cognitive Dysfunction
* Male
* Myeloid Differentiation Factor 88
* NF-kappa B
* Rats
* Rats, Sprague-Dawley
* Sevoflurane
* Signal Transduction
* Sirolimus
* Toll-Like Receptor 4
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755174
}}
==TLR9==
 
{{medline-entry
|title=Age-Associated B Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986068
 
 
|keywords=* B lymphocytes
* aging
* autoimmunity
* memory B cells
|full-text-url=https://sci-hub.do/10.1146/annurev-immunol-092419-031130
}}
==TMEM106B==
 
{{medline-entry
|title=Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526197
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Apolipoproteins E
* Brain
* Cohort Studies
* DNA-Binding Proteins
* Female
* Gene Expression Regulation
* Haplotypes
* Humans
* Lysosomes
* Male
* Membrane Proteins
* Myelin Sheath
* Nerve Tissue Proteins
* Progranulins
* Quantitative Trait Loci
* RNA Splicing Factors
* TDP-43 Proteinopathies
|keywords=* Alzheimer's disease
* Amyloid-β
* GRN
* RBFOX1
* TDP-43
* TMEM106B
* co-expression module
* cognitive resilience
* eQTL
* expression quantitative trait loci
* sQTL
* splicing quantitative trait loci
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416464
}}
==TMPRSS2==
 
{{medline-entry
|title=Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32905655
 
 
|keywords=* SARS-CoV-2
* dysfunction
* exposome
* immunosenescence
* metabolomics
* mitochondria
* pollutant
* socioeconomic
* stress
|full-text-url=https://sci-hub.do/10.1002/jbt.22626
}}
{{medline-entry
|title=Expression of the SARS-CoV-2 Entry Proteins, ACE2 and [[TMPRSS2]], in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32379417
 
|mesh-terms=* Age Factors
* Angiotensin-Converting Enzyme 2
* Animals
* Betacoronavirus
* COVID-19
* Coronavirus Infections
* Gene Expression
* Gene Expression Profiling
* Immunohistochemistry
* In Situ Hybridization
* Mice
* Olfaction Disorders
* Olfactory Mucosa
* Olfactory Receptor Neurons
* Pandemics
* Peptidyl-Dipeptidase A
* Pneumonia, Viral
* RNA-Seq
* Reverse Transcriptase Polymerase Chain Reaction
* SARS-CoV-2
* Serine Endopeptidases
* Virus Internalization
|keywords=* ACE2 expression
* COVID-19
* SARS-CoV-2
* aging
* anosmia
* olfactory epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241737
}}
==TNC==
 
{{medline-entry
|title=Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33217999
 
 
|keywords=* TGF-β
* aging
* collagen
* extracellular matrix
* fibroblast
* skin
* tenascin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698786
}}
{{medline-entry
|title=Tenascin-C expression controls the maturation of articular cartilage in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066496
 
|mesh-terms=* Aging
* Animals
* Cartilage, Articular
* Cell Count
* Genotype
* Mice
* Tenascin
|keywords=* Adhesion
* Articular cartilage
* Cartilage defect
* Cell density
* Knock-out mouse
* Load
* Tenascin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027060
}}
{{medline-entry
|title=Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31877525
 
 
|keywords=* Aging
* Mechanical properties
* Nano-zirconia
* Phase transformation
* Resin nano-ceramic
* Resin-based composite
|full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2019.103522
}}
==TNF==
 
{{medline-entry
|title=Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33234364
 
 
|keywords=* AML-12 cells
* Aging
* ApoE(−/−) mice
* Naringenin
* Nonalcoholic steatohepatitis
* SIRT1
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153412
}}
{{medline-entry
|title=Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33212416
 
 
|keywords=* Aging
* Ferroptosis
* Heme oxygenase-1
* Iron metabolism
* Microglia
* Neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680814
}}
{{medline-entry
|title=Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33147533
 
 
|keywords=* Autophagy
* D-galacose
* Ionizing radiation
* Senescence
* β-hydroxybutyric acid
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104288
}}
{{medline-entry
|title=Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and [[TNF]]-α in regulating cancer pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153895
 
 
|keywords=* Apoptosis
* Autophagy
* EMT
* Fibrogenesis
* Senescence
* TGF-β and TNF-α
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155348
}}
{{medline-entry
|title=Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080448
 
 
|keywords=* Cellular senescence
* Oxidative stress
* SASP
* SNHG29
* Spontaneous preterm birth
* p53/p21
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.10.009
}}
{{medline-entry
|title=Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983153
 
 
|keywords=* chemokines
* cognition
* cytokines
* healthy aging
* immune molecules
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493640
}}
{{medline-entry
|title=Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32920547
 
 
|keywords=* Ribes meyeri anthocyanin
* aging
* cognition
* naringenin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521483
}}
{{medline-entry
|title=Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863968
 
 
|keywords=* Aging
* Inflammation
* Physical exercise
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450596
}}
{{medline-entry
|title=Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32851571
 
 
|keywords=* Aging
* Bone loss
* Osteoclastogenesis
* Periodontitis
* Porphyromonas gingivalis lipopolysaccharide
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00258-1
}}
{{medline-entry
|title=New MoDC-Targeting [[TNF]] Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849581
 
 
|keywords=* 3′
* 5′-cyclic diguanylic acid (cyclic di-GMP)
* aging
* monocyte-derived dendritic cells (moDCs)
* tumor necrosis factor (TNF)
* vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427090
}}
{{medline-entry
|title=Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862311
 
 
|keywords=* Aging
* Biologics
* Cognition
* Rheumatic diseases
|full-text-url=https://sci-hub.do/10.1007/s10067-020-05372-1
}}
{{medline-entry
|title=Cotinine ameliorates memory and learning impairment in senescent mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32818583
 
 
|keywords=* Aging
* Cognitive impairment
* Cotinine
* Improvement
* α(7)nAChRs
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.08.010
}}
{{medline-entry
|title=Kynurenines link chronic inflammation to functional decline and physical frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814718
 
 
|keywords=* Aging
* Cytokines
* Inflammation
* Neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455140
}}
{{medline-entry
|title=Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781061
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Heart
* In Situ Nick-End Labeling
* Male
* Mice
* Mice, Inbred C57BL
* Mitochondria, Heart
* Muscle, Skeletal
* Physical Conditioning, Animal
* Running
* Sedentary Behavior
|keywords=* Caspase-independent
* Cell death
* Fas dependent
* IGF-related
* Mitochondrial
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118187
}}
{{medline-entry
|title=Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751276
 
 
|keywords=* aging
* bioactive
* functional ingredient
* immobilization
* inflammation
* muscle atrophy
* peptide
* protein synthesis
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469066
}}
{{medline-entry
|title=Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744364
 
 
|keywords=* adverse late effects
* childhood
* immune recovery
* immunosenescence
* neuroblastoma
|full-text-url=https://sci-hub.do/10.1002/eji.202048541
}}
{{medline-entry
|title=FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736525
 
 
|keywords=* Endothelial cells
* Fk506
* Hyaluronan
* LYVE-1
* Lung lymphatic
* Senescence
* TERT
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395348
}}
{{medline-entry
|title=Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737921
 
 
|keywords=* aging
* androgen
* heart failure
* myocardial infarction
* testosterone
* thromboembolism
|full-text-url=https://sci-hub.do/10.1111/andr.12876
}}
{{medline-entry
|title=Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738344
 
 
|keywords=* Aging
* Alzheimer's disease
* Inflammation
* Microglia
* Proteomics
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112203
}}
{{medline-entry
|title=Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717588
 
 
|keywords=* Aging
* Alternate day fasting (ADF)
* Intermittent fasting (IF)
* Oxidative stress
* Time-Restricted feeding (TRF)
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104188
}}
{{medline-entry
|title=Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32695109
 
 
|keywords=* HIV
* aging
* anti-retroviral therapy
* inflammation
* morbidity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338430
}}
{{medline-entry
|title=Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679027
 
 
|keywords=* Aging
* chrysin
* inflammation
* liver
* oxidative stress
* rat.
|full-text-url=https://sci-hub.do/10.2174/1871530320666200717162304
}}
{{medline-entry
|title=Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32677895
 
 
|keywords=* Aging
* Ghrelin
* Immunosuppression
* Sepsis
* Vagus nerve
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364485
}}
{{medline-entry
|title=Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590150
 
 
|keywords=* Aging
* Delirium
* Genome-wide DNA methylation
* Immune response
* Inflammatory response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486988
}}
{{medline-entry
|title=[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32560449
 
 
|keywords=* Andrographis paniculata
* andrographolide
* inflammation
* keratinocytes
* oxidative stress
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346124
}}
{{medline-entry
|title=Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569601
 
 
|keywords=* Aging
* Etanercept
* Inflammation
* Learning
* Memory
* TNFα
* Vascular dementia
|full-text-url=https://sci-hub.do/10.1016/j.physbeh.2020.113019
}}
{{medline-entry
|title=Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559006
 
 
|keywords=* NAFLD
* aging
* bacterial translocation
* cytokines
* insulin resistance
|full-text-url=https://sci-hub.do/10.1111/liv.14571
}}
{{medline-entry
|title=Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561691
 
 
|keywords=* BMSCs
* P21/PCNA
* aging
* immune system
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343510
}}
{{medline-entry
|title=Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory [[TNF]]-alpha in human skin explants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583600
 
 
|keywords=* cosmetics
* glycolic acid
* keratolytic agents
* rejuvenation
* skin aging
|full-text-url=https://sci-hub.do/10.1111/jocd.13570
}}
{{medline-entry
|title=A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566144
 
 
|keywords=* A20
* Nuclear factor-kappa B
* Nucleus pulposus
* Senescence
* Tumour necrosis factor alpha
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284293
}}
{{medline-entry
|title=Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32563124
 
|mesh-terms=* Adult
* Aging
* Estradiol
* Female
* Humans
* Hydrocortisone
* Immunity, Cellular
* Intracellular Fluid
* Male
* Middle Aged
* Signal Transduction
* Testosterone
* Young Adult
|keywords=* 17β-estradiol
* Cortisol
* Cytokines
* Testosterone
* Tyrosine hydroxylase
|full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577290
}}
{{medline-entry
|title=Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536956
 
 
|keywords=* Aging
* Complement system
* Elderly
* Immune
* Inflammation
* Lectin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285792
}}
{{medline-entry
|title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532246
 
 
|keywords=* Aging
* FoxO1
* Male osteoporosois
* OPG
* RANKL
* Resveratrol
* SIRT1
* Type II osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293127
}}
{{medline-entry
|title=The senescence-associated secretome as an indicator of age and medical risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554926
 
 
|keywords=* Aging
* Cellular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406245
}}
{{medline-entry
|title=Exercise Partially Rejuvenates Muscle Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32484032
 
 
|keywords=* TGF-beta
* aging
* cyclin D1
* longevity
* regeneration
* stem cells
|full-text-url=https://sci-hub.do/10.1089/rej.2020.2359
}}
{{medline-entry
|title=Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460430
 
|mesh-terms=* Age Factors
* Animals
* Anti-Inflammatory Agents
* Antioxidants
* Cyclooxygenase 2
* Diet, High-Fat
* Dose-Response Relationship, Drug
* Fruit
* Interleukin-1beta
* Interleukin-6
* Lipid Peroxidation
* Male
* Mice
* Myrtaceae
* Oxidative Stress
* Plant Extracts
* Prostatitis
* T-Lymphocytes
|keywords=* aging
* bioactive compounds
* obesity
* overweight
* polyphenols
|full-text-url=https://sci-hub.do/10.1002/pros.24017
}}
{{medline-entry
|title=Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32426041
 
 
|keywords=* Aging
* Diabetes mellitus
* Endothelial cells
* Hypertension
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216374
}}
{{medline-entry
|title=[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32375444
 
|mesh-terms=* Aging
* Animals
* Cognition
* Cognition Disorders
* Fear
* Hippocampus
* Mice
* Mice, Inbred ICR
|keywords=* Central nervous system
* Cognition disorders
* Inflammation
* Postoperative period
* Sleep deprivation
|full-text-url=https://sci-hub.do/10.3760/cma.j.cn112137-20191215-02734
}}
{{medline-entry
|title=Can blocking inflammation enhance immunity during aging?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386656
 
 
|keywords=* Inflammaging
* p38-MAP Kinase
* senescence
* senolytics
|full-text-url=https://sci-hub.do/10.1016/j.jaci.2020.03.016
}}
{{medline-entry
|title=[FAS- and [[TNF]]-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362081
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Female
* Hypothalamus
* Mice
* Mice, Transgenic
* Signal Transduction
* Tumor Necrosis Factor-alpha
* fas Receptor
|keywords=* FAS-, TNF-dependent pathways
* aging
* apoptosis
* hypothalamus
* neurons
 
}}
{{medline-entry
|title=Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332664
 
|mesh-terms=* Aged
* Aged, 80 and over
* Analgesia, Patient-Controlled
* Delirium
* Esophagectomy
* Female
* Geriatrics
* Humans
* Male
* Middle Aged
* Nerve Block
* Postoperative Complications
* Prospective Studies
* Ultrasonography
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440095
}}
{{medline-entry
|title=17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311377
 
|mesh-terms=* Aging
* Animals
* Anti-Inflammatory Agents
* Blood Glucose
* Cytokines
* Estradiol
* Female
* Heart
* Insulin
* Insulin Resistance
* Lipid Metabolism
* Menopause
* Ovariectomy
* Rats
* Rats, Wistar
* Signal Transduction
|keywords=* 17β-estradiol
* Aging
* Cytokines
* Heart
* Insulin signalling
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117673
}}
{{medline-entry
|title=Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32252879
 
|mesh-terms=* Adenocarcinoma
* Aging
* Animals
* Cell Line, Tumor
* Glycols
* Humans
* Mice
* Nanoparticles
* Polylactic Acid-Polyglycolic Acid Copolymer
* Selenium Compounds
 
|full-text-url=https://sci-hub.do/10.1166/jbn.2020.2890
}}
{{medline-entry
|title=Pinitol suppresses [[TNF]]-α-induced chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200264
 
 
|keywords=* Cellular senescence
* Nrf2
* Osteoarthritis
* Pinitol
* TNF-α
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155047
}}
{{medline-entry
|title=[Aging of skin fibroblasts: genetic and epigenetic factors.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160428
 
|mesh-terms=* Cells, Cultured
* Epigenesis, Genetic
* Fibroblasts
* Humans
* Skin Aging
|keywords=* aging
* melatonin
* signal molecules
* skin fibroblasts
 
}}
{{medline-entry
|title=Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151735
 
 
|keywords=* Aging
* Cytokines.
* Dynapenia
* Inflamm-aging
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110920
}}
{{medline-entry
|title=Associations of [[TNF]]-α -308 G>A and [[TNF]]-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115620
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Female
* Humans
* Longevity
* Male
* Natriuretic Peptide, Brain
* Tumor Necrosis Factor-alpha
|keywords=* Physical function
* TNF-α -308 G>A polymorphism
* TNF-β 252 A>G polymorphism
* plasma BNP
* population study.
|full-text-url=https://sci-hub.do/10.1007/s12603-020-1336-1
}}
{{medline-entry
|title=3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104405
 
 
|keywords=* 3D TECA
* Cellular senescence
* Fibroblast migration
* SA-β-gal
* TNF-α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032142
}}
{{medline-entry
|title=Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32099340
 
|mesh-terms=* Animals
* Antioxidants
* Apoptosis
* Cytokines
* Immunologic Factors
* Immunosenescence
* Male
* Medicine, Chinese Traditional
* Mice
* Models, Animal
* NF-E2-Related Factor 2
* Oxidative Stress
* Phytochemicals
* Schisandra
* Spleen
|keywords=* Anwulignan
* anti-apoptosis
* antioxidation
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996228
}}
{{medline-entry
|title=Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105728
 
 
|keywords=* Aging
* Immunosuppression
* Side Effect
* Thiopurine
|full-text-url=https://sci-hub.do/10.1053/j.gastro.2020.02.032
}}
{{medline-entry
|title=The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047577
 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Cell Line
* Cellular Senescence
* Citrus
* Cytoprotection
* Disease Models, Animal
* Flavanones
* Humans
* Interleukin-6
* Mice
* Myocardium
* Protein Binding
* Rats
* Reactive Oxygen Species
* Sirtuin 1
* Tumor Necrosis Factor-alpha
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003265
}}
{{medline-entry
|title=In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947966
 
 
|keywords=* IL-12
* IL-18
* TCR bypass stimulation
* senescence
* γδ T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017313
}}
{{medline-entry
|title=Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904410
 
 
|keywords=* Aging
* Cytokines
* ERα
* Estrogen
* Leptin sensitivity
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111198
}}
{{medline-entry
|title=Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885820
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Cytokines
* Humans
* Inflammation Mediators
* Mitochondria
* Neurofibrillary Tangles
* Neurons
* Neuroprotective Agents
* Thioctic Acid
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914903
}}
{{medline-entry
|title=Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837501
 
|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Anti-Inflammatory Agents, Non-Steroidal
* Astrocytes
* Carbamates
* Cell Line, Tumor
* Cell Survival
* Diosgenin
* Dose-Response Relationship, Drug
* Drug Design
* Galactose
* Humans
* Inflammation
* Male
* Mice
* Mice, Inbred ICR
* Molecular Structure
* Neuroprotective Agents
* Oxidative Stress
* Protein Aggregates
* Structure-Activity Relationship
|keywords=* Alzheimer’s disease
* Anti-Aβ activity
* Anti-inflammatory
* Antioxidant
* Diosgenin
* Multi-target-directed ligands
|full-text-url=https://sci-hub.do/10.1016/j.ejmech.2019.111913
}}
{{medline-entry
|title=Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816987
 
|mesh-terms=* Aging
* Animal Feed
* Animals
* Brain-Derived Neurotrophic Factor
* Cognitive Dysfunction
* Diet
* Gastrointestinal Microbiome
* Gene Expression Regulation
* Hippocampus
* Male
* Mice
* Soybeans
* Tumor Necrosis Factor-alpha
|keywords=* BDNF
* SAMP8
* cognitive impairment
* neuroprotection
* okara
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950093
}}
{{medline-entry
|title=Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31759387
 
|mesh-terms=* Aging
* Anesthesia, General
* Animals
* Behavior, Animal
* Hippocampus
* Inflammation
* Male
* Maze Learning
* NF-kappa B
* Postoperative Cognitive Complications
* Rats
* Rats, Sprague-Dawley
* Splenectomy
* Tumor Necrosis Factor-alpha
* Vagus Nerve Stimulation
|keywords=* Cognitive dysfunction
* General anesthesia
* Inflammation
* Vagus nerve stimulation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875068
}}
{{medline-entry
|title=Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772144
 
|mesh-terms=* Animals
* Annulus Fibrosus
* Anti-Inflammatory Agents
* Cellular Senescence
* HMGB1 Protein
* Inflammation
* Intervertebral Disc Degeneration
* Lipopolysaccharides
* Metformin
* Rabbits
* Stem Cells
|keywords=* HMGB1
* annulus fibrosis stem cells
* cell senescence
* intervertebral disc degeneration
* metformin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914423
}}
{{medline-entry
|title=The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746877
 
|mesh-terms=* Aged
* Aging
* Animals
* Blueberry Plants
* Double-Blind Method
* Female
* Fragaria
* Fruit
* Humans
* Male
* Microglia
* Middle Aged
* Nitric Oxide
* Nitric Oxide Synthase Type II
* Oxidative Stress
* Postprandial Period
* Rats
* Tumor Necrosis Factor-alpha
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906224
}}
{{medline-entry
|title=Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31734849
 
 
|keywords=* Aging
* Arsenic
* Articular cartilage
* Human chondrocyte
* Senescence
* Senescence-associated secretory phenotype
|full-text-url=https://sci-hub.do/10.1007/s00204-019-02607-2
}}
{{medline-entry
|title=Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717258
 
|mesh-terms=* Age Factors
* Animals
* Bone Density
* Bone Density Conservation Agents
* Bone Marrow Cells
* Bone Remodeling
* Bone and Bones
* Cells, Cultured
* Cytokines
* Dietary Supplements
* Disease Models, Animal
* Docosahexaenoic Acids
* Eicosapentaenoic Acid
* Female
* JNK Mitogen-Activated Protein Kinases
* Mice, Inbred C57BL
* Osteoporosis
* Signal Transduction
* p38 Mitogen-Activated Protein Kinases
|keywords=* aging
* bone mineral density
* bone resorption
* concentrated fish oil
* cytokines
* inflammation
* omega-3 fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893665
}}
{{medline-entry
|title=Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31713098
 
|mesh-terms=* Aging
* Animals
* Chronic Disease
* Cytokines
* Disease Models, Animal
* Epithelium
* Flow Cytometry
* Immunity, Innate
* Inflammation
* Macaca mulatta
* NK Cell Lectin-Like Receptor Subfamily B
* Phenotype
* Th17 Cells
|keywords=* CD161+ cells
* I-FABP
* Inflammaging
* LBP
* Leaky gut
* sCD14
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925095
}}
{{medline-entry
|title=Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31719197
 
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* Case-Control Studies
* Cell Differentiation
* Cells, Cultured
* Clonal Evolution
* Gene Expression Profiling
* Humans
* Interferon-gamma
* Leukocytes, Mononuclear
* Middle Aged
* Single-Cell Analysis
* Tumor Necrosis Factor-alpha
|keywords=* CD4 CTL
* aging
* centenarian
* single-cell transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883788
}}
{{medline-entry
|title=Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704617
 
|mesh-terms=* Aging
* Animals
* Bacteria
* Biomarkers
* Drugs, Chinese Herbal
* Gastrointestinal Microbiome
* Hyperlipidemias
* Lipid Metabolism
* Male
* Metabolome
* Metabolomics
* Mice
* Mice, Inbred C57BL
|keywords=* Aging
* FTZ
* Gut microbiota
* Metabolomics
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2019.109550
}}
{{medline-entry
|title=Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669486
 
|mesh-terms=* Aging
* Animals
* Apoptosis
* Cytokines
* Estrogens
* Female
* Humans
* Inflammation
* Intervertebral Disc
* Intervertebral Disc Degeneration
* Intervertebral Disc Displacement
* Male
* Phosphatidylinositol 3-Kinases
* Signal Transduction
|keywords=* Ageing
* Apoptosis
* Intervertebral disc degeneration
* Oestrogen
* Spine
|full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100978
}}
{{medline-entry
|title=MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654705
 
|mesh-terms=* Aging
* Animals
* Caloric Restriction
* Cytokines
* Diet Therapy
* Inflammation
* Interleukin-1beta
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* MicroRNAs
* Models, Animal
* RAW 264.7 Cells
* Transcriptional Activation
* Tumor Necrosis Factor-alpha
* Up-Regulation
|keywords=* Caloric restriction
* Cellular immunology
* Cytokines
* Macrophages
* microRNA
|full-text-url=https://sci-hub.do/10.1016/j.gene.2019.144191
}}
{{medline-entry
|title=Aerobic exercise modulates cytokine profile and sleep quality in elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656505
 
|mesh-terms=* Aged
* Cytokines
* Exercise
* Female
* Humans
* Male
* Middle Aged
* Sedentary Behavior
* Sleep Wake Disorders
|keywords=* Sleep quality
* aerobic exercise
* aging
* inflammatory cytokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794533
}}
{{medline-entry
|title=Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630800
 
|mesh-terms=* Aging
* Animals
* Disease Models, Animal
* Dose-Response Relationship, Drug
* Galactose
* Male
* Memory Disorders
* Mice
* Mice, Inbred ICR
* NF-E2-Related Factor 2
* Signal Transduction
* Trehalose
|keywords=* Antioxidant stress
* Cognitive impairment
* Inflammation
* Nrf2
* Trehalose
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.088
}}
{{medline-entry
|title=Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31623220
 
|mesh-terms=* Aging
* Animals
* Anti-Inflammatory Agents
* Antioxidants
* Biological Products
* Chlorella
* Cytokines
* Disease Models, Animal
* Galactose
* Inflammation
* Interleukin-6
* Lipopolysaccharides
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* NF-kappa B
* Nitric Oxide
* Oxidative Stress
* RAW 264.7 Cells
* Superoxide Dismutase
* Tumor Necrosis Factor-alpha
|keywords=* Chlorella pyrenoidosa
* NF-κB
* PPARs
* anti-aging
* anti-inflammation
* pigment–protein complex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836285
}}
{{medline-entry
|title=Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606818
 
 
|keywords=* Aging
* BACE
* Cytokines
* Disability
* Fall risk
* Low back pain
|full-text-url=https://sci-hub.do/10.1007/s00586-019-06168-x
}}
{{medline-entry
|title=Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583530
 
 
|keywords=* Acetylcholinesterase inhibitor
* Aging
* CHRFAM7A
* CHRNA7
* Cholinergic anti-inflammatory pathway
* Neuroinflammation
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01359-4
}}
{{medline-entry
|title=Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555127
 
 
|keywords=* Fufang Zhenzhu Tiaozhi
* liver aging
* mass spectrometry
* metabolomics
* ultra-performance liquid chromatography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722462
}}
{{medline-entry
|title=Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31549145
 
 
|keywords=* Brain aging
* Cognition
* Gray matter volume
* Inflammation
* Neuroimaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457183
}}
{{medline-entry
|title=Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521202
 
|mesh-terms=* Adipose Tissue
* Adult
* Cell Movement
* Cell Proliferation
* Cell Survival
* Cellular Senescence
* Dasatinib
* Female
* Humans
* Mesenchymal Stem Cells
* Pre-Eclampsia
* Pregnancy
* Protein Kinase Inhibitors
|keywords=* Angiogenesis, Senolytics, Dasatinib
* Mesenchymal stem cells
* Preeclampsia
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744626
}}
{{medline-entry
|title=Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413350
 
|mesh-terms=* Aging
* Animals
* Bifidobacterium longum
* Cognitive Dysfunction
* Dysbiosis
* Feces
* Gastrointestinal Microbiome
* Humans
* Lipopolysaccharides
* Mice
* Mice, Transgenic
* Probiotics
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694197
}}
{{medline-entry
|title=Moderate hyperoxia induces senescence in developing human lung fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31411059
 
|mesh-terms=* Autophagy
* CCAAT-Enhancer-Binding Protein-beta
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* DNA Damage
* Endoplasmic Reticulum Stress
* Etoposide
* Extracellular Matrix
* Fetus
* Fibroblasts
* G2 Phase Cell Cycle Checkpoints
* Gene Expression Regulation
* Humans
* Hyperoxia
* Interleukin-1
* Interleukin-8
* Lung
* Matrix Metalloproteinase 3
* Oxygen
* Plasminogen Activator Inhibitor 1
* Primary Cell Culture
* Tumor Necrosis Factor-alpha
* Tumor Suppressor Protein p53
|keywords=* autophagy
* endoplasmic reticulum stress
* lung development
* oxygen
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879905
}}
{{medline-entry
|title=Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389127
 
|mesh-terms=* Aged
* Aging
* Animals
* Antigens, CD
* Cell Adhesion Molecules
* Cells, Cultured
* Endothelium, Vascular
* Humans
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Signal Transduction
|keywords=* aging
* anti-aging
* cytokines
* inflammation
* mouse
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826129
}}
{{medline-entry
|title=Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1  Transgenic Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417357
 
 
|keywords=* aging
* cerebral amyloidosis
* insulin-like growth factor
* neurogenesis
* neuroinflammation
* tumor necrosis factor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682662
}}
{{medline-entry
|title=Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400786
 
|mesh-terms=* Aging
* Animals
* Chlorpyrifos
* Diet, High-Fat
* Gastrointestinal Microbiome
* Hypothalamo-Hypophyseal System
* Inflammation
* Male
* Pituitary-Adrenal System
* RNA, Ribosomal, 16S
* Rats
|keywords=* 16S rRNA gene sequencing
* Gut endocrine
* Gut-brain axis
* Hormone
* Hypothalamic-pituitary-adrenal axis
* Inflammation
|full-text-url=https://sci-hub.do/10.1016/j.pestbp.2019.05.018
}}
==TOMM20==
 
{{medline-entry
|title=Effect of aging on mitochondria and metabolism of bovine granulosa cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32921645
 
 
|keywords=* Aging
* Cow
* Granulosa cells
* Mitochondria
|full-text-url=https://sci-hub.do/10.1262/jrd.2020-071
}}
==TP53==
 
{{medline-entry
|title=p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473528
 
 
|keywords=* Cellular senescence
* Dental follicle cells
* E2F-1
* Osteogenic differentiation
* p53
|full-text-url=https://sci-hub.do/10.1016/j.diff.2020.05.003
}}
{{medline-entry
|title=Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243522
 
|mesh-terms=* Age Factors
* Aged
* Aging
* Anemia
* Female
* Hematopoiesis
* Humans
* Kaplan-Meier Estimate
* Male
* Middle Aged
* Mutation
* Prospective Studies
 
|full-text-url=https://sci-hub.do/10.1182/blood.2019004362
}}
{{medline-entry
|title=[[TP53]]/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986125
 
 
|keywords=* Aging
* PDAC
* SERPINE1
* TP53
* cancer
* miR-34a
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041729
}}
{{medline-entry
|title=Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31933915
 
 
|keywords=* CDK4
* MDM2
* TP53
* nodular fasciitis
* p16
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945175
}}
==TPH1==
 
{{medline-entry
|title=[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33245015
 
 
|keywords=* Lactobacillus spp.
* aging
* brain
|full-text-url=https://sci-hub.do/10.3920/BM2019.0200
}}
==TPO==
 
{{medline-entry
|title=Megakaryocytes promote osteoclastogenesis in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634116
 
 
|keywords=* aging
* bone marrow macrophage
* megakaryocyte
* osteoclast
* thrombopoietin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425434
}}
==TPP1==
 
{{medline-entry
|title=FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33086033
 
 
|keywords=* DNA damage response
* FBXW7
* TPP1
* cellular senescence
* chronic stress
* idiopathic pulmonary fibrosis
* premature aging
* proteostasis
* stem cells
* telomere
* telomere uncapping
|full-text-url=https://sci-hub.do/10.1016/j.cmet.2020.10.004
}}
==TPR==
 
{{medline-entry
|title=Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143192
 
 
|keywords=* Cu loading
* Cu/MCM-22
* NH3-SCR
* hydrothermal aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694057
}}
{{medline-entry
|title=Do traits of plant species predict the efficacy of species distribution models for finding new occurrences?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32551077
 
 
|keywords=* dispersal
* generalist
* lifespan
* niche models
* range size
* specialist
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297770
}}
{{medline-entry
|title=In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31541957
 
 
|keywords=* Aging resistance
* Amorphization
* Surface modification
* Symmetrical structure
|full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2019.121210
}}
==TRAF3==
 
{{medline-entry
|title=[[TRAF3]], a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32111144
 
 
|keywords=* TRAF3
* adipogenic differentiation
* bone marrow-derived mesenchymal stem cells
* miR-363-3p
* osteogenic differentiation
* senescence
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0276
}}
==TREM2==
 
{{medline-entry
|title=Loss of [[TREM2]] Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33139402
 
 
|keywords=* TREM2
* aging
* dendritic spine density
* learning and memory
* long-term potentiation
* synaptic plasticity
|full-text-url=https://sci-hub.do/10.1523/JNEUROSCI.2193-20.2020
}}
{{medline-entry
|title=Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33101276
 
 
|keywords=* NKG2D ligands
* aging
* inflammation
* interferon type I response
* microglia
* neurodegeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546799
}}
{{medline-entry
|title=Knockdown of astrocytic [[TREM2]] in the hippocampus relieves cognitive decline in elderly male mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32991925
 
 
|keywords=* Aging
* Long-term potentiation
* TREM2
* astrocytes
* learning and memory
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2020.112939
}}
==TRIM21==
 
{{medline-entry
|title=[[TRIM21]] overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064156
 
 
|keywords=* Glioma
* TRIM21
* cell senescence
* drug resistance
* p53-p21 pathway
* prognosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017742
}}
==TRIM27==
 
{{medline-entry
|title=[[TRIM27]] Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251042
 
 
|keywords=* EP300
* TRIM27
* breast cancer
* cell apoptosis
* cell senescence
* chemoresistance
* p21
* prognosis
* transcription
* ubiquitination
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666371
}}
==TRIP13==
 
{{medline-entry
|title=BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31738183
 
|mesh-terms=* Aging
* Alleles
* Animals
* Cell Cycle Proteins
* Chromosome Disorders
* Lung Neoplasms
* Mice
* Mice, Inbred C57BL
* Mitosis
* Mosaicism
* Mutation
* Phenotype
* Progeria
* Protein-Serine-Threonine Kinases
|keywords=* Aging
* Cancer
* Cellular senescence
* Genetic diseases
* Oncology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934189
}}
==TRPC6==
 
{{medline-entry
|title=Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32686475
 
 
|keywords=* SASP
* Senescence
* TRPC6
* calcium
* hydrogen peroxide
* mTOR
|full-text-url=https://sci-hub.do/10.1177/1535370220943122
}}
==TRPC7==
 
{{medline-entry
|title=Nociceptive transient receptor potential canonical 7 ([[TRPC7]]) mediates aging-associated tumorigenesis induced by ultraviolet B.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755176
 
 
|keywords=* TRPC7
* aging
* p53
* tumor initiator gene
* tumorigenesis
* ultraviolet pathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974716
}}
==TRPV4==
 
{{medline-entry
|title=[[TRPV4]] receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31914645
 
|mesh-terms=* Animals
* Calcium
* Guinea Pigs
* Humans
* Muscle Contraction
* Muscle, Smooth
* TRPV Cation Channels
* Urinary Bladder
* Urothelium
|keywords=* ATP release
* TRPV4 receptor
* aging
* overactive bladders
* urothelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973053
}}
{{medline-entry
|title=Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the [[TRPV4]]-K 2.3 signaling complex.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31564840
 
|mesh-terms=* Animals
* Biological Factors
* Cardiovascular Diseases
* Endothelial Cells
* Endothelium, Vascular
* Male
* Potassium Channels, Calcium-Activated
* Rats
* Rats, Sprague-Dawley
* TRPV Cation Channels
* Vasodilation
|keywords=* EDHF
* KCa2.3
* TRPV4
* aging
* endothelium
* exercise
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731547
}}
==TSPO==
 
{{medline-entry
|title=Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749696
 
 
|keywords=* 18 kDa translocator protein
* aging
* astrocytes
* microglia
* neuroinflammation
* triggering receptor expressed on myeloid cells 2
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848890
}}
{{medline-entry
|title=Upregulation of cannabinoid receptor type 2, but not [[TSPO]], in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707986
 
|mesh-terms=* Aging
* Animals
* Brain
* Inflammation
* Mice
* Microglia
* Positron-Emission Tomography
* Radiopharmaceuticals
* Receptor, Cannabinoid, CB2
* Receptors, GABA
* Up-Regulation
|keywords=* Cannabinoid receptor type 2
* Immunostaining
* Microglial activation
* Positron emission tomography
* Senescence-accelerated prone mouse
* Translocator protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842455
}}
==TST==
 
{{medline-entry
|title=H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and [[TST]] Expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848752
 
 
|keywords=* aging
* donor
* fructose
* gastric mucosa
* hydrogen sulfide
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396573
}}
{{medline-entry
|title=Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239311
 
 
|keywords=* Aging
* Concurrent training
* Explosive force
* Functional capacity
* HIIT
|full-text-url=https://sci-hub.do/10.1007/s00421-020-04355-z
}}
{{medline-entry
|title=Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31602410
 
|mesh-terms=* Adult
* Aged
* Aging
* Body Mass Index
* Cardiovascular Diseases
* Cohort Studies
* Female
* Humans
* Male
* Middle Aged
* Risk Factors
* Self Report
* Sleep
* Telomere
* Waist Circumference
* Wearable Electronic Devices
* Young Adult
|keywords=* Data integration
* Predictive markers
* Risk factors
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778117
}}
{{medline-entry
|title=Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31579942
 
|mesh-terms=* Accelerometry
* Aged
* Aging
* Cross-Sectional Studies
* Exercise
* Female
* Health Status
* Humans
* Independent Living
* Ireland
* Longitudinal Studies
* Male
* Polysomnography
* Self Report
* Sleep
* Time Factors
|keywords=* GENEActiv
* accelerometer
* actigraphy
* older population
* sleep duration
|full-text-url=https://sci-hub.do/10.1111/jgs.16177
}}
==TTL==
 
{{medline-entry
|title=Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986512
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biomarkers
* Body Mass Index
* Cohort Studies
* Female
* Germany
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Oxidative Stress
* Waist Circumference
* Waist-Hip Ratio
|keywords=* Body mass index
* Free radicals
* Oxidative stress
* Reactive oxygen metabolites
* Total thiol levels
* Waist circumference
* Waist-to-hip ratio
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098284
}}
==TTN==
 
{{medline-entry
|title=LncRNA [[TTN]]-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600142
 
|mesh-terms=* Aging
* Apoptosis
* Brain Neoplasms
* Cell Line, Tumor
* Cell Proliferation
* Chromosomal Proteins, Non-Histone
* Computational Biology
* Drug Resistance
* Gene Expression Regulation, Neoplastic
* Humans
* MicroRNAs
* Osteosarcoma
* RNA, Long Noncoding
|keywords=* aging and age-related diseases
* lncRNA TTN-AS1
* malignant brain tumour domain containing protein 1
* miR-134-5p
* osteosarcoma
* resistance
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814585
}}
==TTR==
 
{{medline-entry
|title=Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31728576
 
|mesh-terms=* Amyloid Neuropathies, Familial
* Animals
* Cell Death
* Cell Line, Tumor
* Disease Models, Animal
* Drosophila
* HEK293 Cells
* Humans
* Locomotion
* Longevity
* Mutant Proteins
* Mutation
* Nerve Degeneration
* Prealbumin
|keywords=* Amyloidosis
* Drosophila melanogaster
* ERQC
* Endoplasmic reticulum quality control
* Proteostasis
* TTR
* Transthyretin
|full-text-url=https://sci-hub.do/10.1007/s00018-019-03357-1
}}
==TXNIP==
 
{{medline-entry
|title=Panax notoginseng saponins attenuate neuroinflammation through [[TXNIP]]-mediated NLRP3 inflammasome activation in aging rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33176641
 
 
|keywords=* Aging
* Microglia
* NLRP3 inflammasome
* Saponins from Panax notoginseng.
* TXNIP
* neuroinflammation
|full-text-url=https://sci-hub.do/10.2174/1389201021999201110204735
}}
{{medline-entry
|title=Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein ([[TXNIP]]).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33128997
 
 
|keywords=* Aging
* Beta-cells
* Cell cycle
* Metabolic stress
* Redox homeostasis
* Thioredoxin-interacting protein
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589534
}}
{{medline-entry
|title=[Effect of diabetic induced thioredoxin interacting protein ([[TXNIP]]) on islet cell senescence].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744003
 
|mesh-terms=* Animals
* Carrier Proteins
* Cellular Senescence
* Diabetes Mellitus, Experimental
* Islets of Langerhans
* Mice
* Thioredoxins
|keywords=* INS-1 cell
* cell senescence
* diabetes
* thioredoxin interacting protein
|full-text-url=https://sci-hub.do/10.12047/j.cjap.5878.2020.027
}}
{{medline-entry
|title=PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the [[TXNIP]]/p21 axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32023548
 
 
|keywords=* PRMT5
* TRIM21
* TXNIP
* p21
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041745
}}
==TXNRD2==
 
{{medline-entry
|title=Wogonin induces cellular senescence in breast cancer via suppressing [[TXNRD2]] expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671444
 
 
|keywords=* Breast cancer
* Immune surveillance
* ROS
* Senescence
* TXNRD2
* Wogonin
|full-text-url=https://sci-hub.do/10.1007/s00204-020-02842-y
}}
==U2AF1==
 
{{medline-entry
|title=Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32141009
 
 
|keywords=* Aging
* DEPs
* HSPC
* iTRAQ
* mRNA splicing
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01509-z
}}
==UACA==
 
{{medline-entry
|title=Knockdown of [i][[UACA]][/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31949867
 
 
|keywords=* HIF1α
* UACA
* hepatocellular carcinoma
* invasion
* knockdown
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962967
}}
==UCHL1==
 
{{medline-entry
|title=Abolishing [[UCHL1]]'s hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33159930
 
 
|keywords=* Aging
* Axonal injury
* Neurodegeneration
* Traumatic brain injury
* Ubiquitin carboxy terminal hydrolase L1
* Ubiquitin proteasome pathway
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113524
}}
==UCP1==
 
{{medline-entry
|title=Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32464603
 
 
|keywords=* adipose tissue
* aging
* growth hormone
* inflammation
* uncoupling protein 1 (UCP1)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288969
}}
{{medline-entry
|title=Lack of [[UCP1]] stimulates fatty liver but mediates [[UCP1]]-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32179129
 
 
|keywords=* Apoe knockout mice
* Beige fat
* Gene expression
* Hyperlipidemia
* Longevity
* Uncoupling protein 1
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165762
}}
{{medline-entry
|title=Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31961706
 
|mesh-terms=* Adipocytes, Beige
* Adipocytes, White
* Adipose Tissue
* Aging
* Animals
* Dose-Response Relationship, Drug
* Female
* Leptin
* Male
* Mice
* Mice, Obese
* Sympathetic Nervous System
* Tyrosine 3-Monooxygenase
* Uncoupling Protein 1
|keywords=* beige adipocytes
* leptin
* sympathetic nerve system
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191411
}}
{{medline-entry
|title=Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31806023
 
|mesh-terms=* Adipose Tissue, Brown
* Aging
* Animals
* Brain
* Female
* Male
* Mice, Inbred C57BL
* Mitochondrial Proteins
* Muscle, Skeletal
* Sex Characteristics
* Spleen
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896328
}}
{{medline-entry
|title=An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31427677
 
|mesh-terms=* Adipocytes
* Aging
* Animals
* Humans
* Inflammation
* Intra-Abdominal Fat
* Macrophages
* Mice
* Obesity
* Phenotype
* Physical Conditioning, Animal
* Resistance Training
 
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700172
}}
==UGT2B28==
 
{{medline-entry
|title=Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a [[UGT2B28]] genomic variation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31805979
 
|mesh-terms=* Adult
* Age of Onset
* Aged
* Aged, 80 and over
* Carcinoma, Hepatocellular
* Female
* Genetic Association Studies
* Genetic Predisposition to Disease
* Glucuronosyltransferase
* Humans
* Life Expectancy
* Liver Neoplasms
* Male
* Middle Aged
* Neoplasm Metastasis
* Neoplasm Recurrence, Local
* Odds Ratio
* Polymorphism, Single Nucleotide
* Survival Analysis
* Young Adult
|keywords=* Alcoholism
* Xenobiotic metabolizing enzymes
* Young hepatocellular carcinoma; age of death
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896495
}}
==USP7==
 
{{medline-entry
|title=Deubiquitinase [[USP7]] regulates [i]Drosophila[/i] aging through ubiquitination and autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221768
 
 
|keywords=* DMC
* Drosophila
* USP7
* aging
* autophagy
|full-text-url=https://sci-hub.do/10.18632/aging.104067
}}
==VCAM1==
 
{{medline-entry
|title=Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32993785
 
 
|keywords=* Cell senescence
* Metastasis
* Metastatic breast cancer (MBC)
* Receptor tyrosine kinase (RTK)
* Sunitinib
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526390
}}
==VDAC1==
 
{{medline-entry
|title=Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and [[VDAC1]] predicts mammalian longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32353747
 
 
|keywords=* Complex I
* Droplet digital PCR
* Longevity
* Mammals
* Mitochondria
* NDUFS4 subunit
* NDUFV2 subunit
* VDAC
* Western blot
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191849
}}
{{medline-entry
|title=Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173460
 
 
|keywords=* Aging
* Colonic crypt
* Expression
* Intestine
* Mitochondria
* OXPHOS
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110924
}}
==VDR==
 
{{medline-entry
|title=25-Hydroxyvitamin D  positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917967
 
 
|keywords=* 25-Hydroxyvitamin D(3)
* Diabetic periodontitis
* Inflammaging
* SOCS3
* Senescence
* Senescence-associated secretory phenotypes
|full-text-url=https://sci-hub.do/10.1016/j.steroids.2019.108570
}}
{{medline-entry
|title=1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel [[VDR]]-Ezh2-p16 signal axis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31880094
 
|mesh-terms=* 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
* Aging
* Animals
* Bone and Bones
* Cells, Cultured
* Cyclin-Dependent Kinase Inhibitor p16
* Cyclin-Dependent Kinase Inhibitor p19
* DNA Damage
* Enhancer of Zeste Homolog 2 Protein
* Female
* Histones
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Knockout
* Osteocytes
* Osteogenesis
* Osteoporosis
* Oxidative Stress
* Receptors, Calcitriol
* Vitamin D
|keywords=* Ezh2
* Vitamin D
* cellular senescence
* osteogenesis
* osteoporosis
* p16
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996957
}}
{{medline-entry
|title=Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31810868
 
 
|keywords=* Active vitamin D
* Cell senescence
* Non-alcoholic fatty liver disease
* Oxidative stress
* P53-p21 signaling pathway
* Vitamin D receptor
|full-text-url=https://sci-hub.do/10.1016/j.clinre.2019.10.007
}}
==VEGFA==
 
{{medline-entry
|title=APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31791659
 
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Apolipoprotein E4
* Cognitive Aging
* Cognitive Dysfunction
* Female
* Gene Expression
* Genetic Association Studies
* Genetic Predisposition to Disease
* Genotype
* Humans
* Male
* Neovascularization, Physiologic
* Neuropilin-1
* Vascular Endothelial Growth Factor A
|keywords=* APOE-ε4
* Aging
* Cognition
* Gene expression
* Vascular endothelial growth factor (VEGF)
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064375
}}
==VGLL4==
 
{{medline-entry
|title=The lncRNA MEG3/miR-16-5p/[[VGLL4]] regulatory axis is involved in etoposide-induced senescence of tumor cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141998
 
 
|keywords=* LncRNA MEG3
* breast cancer
* cell senescence
* etoposide
* lung adenocarcinoma
|full-text-url=https://sci-hub.do/10.1002/jgm.3291
}}
==VHL==
 
{{medline-entry
|title=Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a [[VHL]]-1-independent transcriptional response.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399915
 
 
|keywords=* Aging
* C. elegans
* EGL-9/PHD
* HIF-1 signaling
* Hypoxic response
* Lifespan
* RHY-1
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00194-0
}}
==VIM==
 
{{medline-entry
|title=Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31898011
 
|mesh-terms=* Aging
* Animals
* Cell Culture Techniques
* Cell Line
* Cell Proliferation
* Cell Shape
* Chromosomes, Mammalian
* Fibroblasts
* Male
* Muntjacs
* Postmortem Changes
* Skin
|keywords=* Characteristics
* Chinese muntjac
* Fibroblast cell line
* Postmortem skin
|full-text-url=https://sci-hub.do/10.1007/s11626-019-00422-8
}}
==VIP==
 
{{medline-entry
|title=Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 [[VIP]] Interneurons During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33173468
 
 
|keywords=* VIP
* action potential
* aging
* calretinin
* circuit disinhibition
* hippocampus
* synapse
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591401
}}
{{medline-entry
|title=Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33052590
 
 
|keywords=* Aging
* Cognitive impairment
* Exercise
* Meta-analysis
* Nutrition
|full-text-url=https://sci-hub.do/10.1007/s40520-020-01730-w
}}
==VSIG4==
 
{{medline-entry
|title=Immune checkpoint protein [[VSIG4]] as a biomarker of aging in murine adipose tissue.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856419
 
 
|keywords=* VSIG4
* adipose tissue
* aging
* frailty index
* immune checkpoint
* inflammation
* macrophage
* mouse
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576241
}}
==WASL==
 
{{medline-entry
|title=Loss of Wasl improves pancreatic cancer outcome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434991
 
 
|keywords=* Cancer
* Cellular senescence
* Mouse models
* Oncology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259520
}}
==WDR5==
 
{{medline-entry
|title=Inhibition of the H3K4 methyltransferase MLL1/[[WDR5]] complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 .
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570196
 
|mesh-terms=* Acute Kidney Injury
* Animals
* Biphenyl Compounds
* Cell Line
* Cyclin-Dependent Kinase Inhibitor p16
* Dihydropyridines
* Drug Evaluation, Preclinical
* Fibroblasts
* Histone-Lysine N-Methyltransferase
* Histones
* Intracellular Signaling Peptides and Proteins
* Male
* Mice, Inbred C57BL
* Myeloid-Lymphoid Leukemia Protein
* Rats
* Renal Insufficiency
* Reperfusion Injury
|keywords=* H3K4me3
* MLL1
* WDR5
* acute kidney injury
* p16(INK4a)
* senescence
|full-text-url=https://sci-hub.do/10.1016/j.kint.2019.06.021
}}
==WFDC2==
 
{{medline-entry
|title=Differences in biomarkers and molecular pathways according to age for patients with HFrEF.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002110
 
 
|keywords=* aging
* biological age
* biomarkers
* chronological age
* heart failure with reduced ejection fraction
|full-text-url=https://sci-hub.do/10.1093/cvr/cvaa279
}}
==WIPI2==
 
{{medline-entry
|title=Neuronal autophagy declines substantially with age and is rescued by overexpression of [[WIPI2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794336
 
|mesh-terms=* Aging
* Animals
* Autophagy
* Autophagy-Related Proteins
* Mice, Transgenic
* Models, Biological
* Neurons
* Phagosomes
* Phosphate-Binding Proteins
* RNA, Messenger
|keywords=* Aging
* WIPI2
* autophagosome biogenesis
* autophagy
* macroautophagy
* neurodegeneration
* neuronal autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984449
}}
==WNT1==
 
{{medline-entry
|title=Plasma proteomic profile of age, health span, and all-cause mortality in older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33089916
 
 
|keywords=* SomaScan® assay
* aging
* proteomics
* weighted gene co-expression network analysis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681045
}}
==WNT10A==
 
{{medline-entry
|title=Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964233
 
 
|keywords=* Wnt signaling pathway
* cell senescence
* differentiation
* osteoarthritis
* synovial mesenchymal stem cells (SMSCs)
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0260
}}
==WNT3A==
 
{{medline-entry
|title=Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109549
 
 
|keywords=* ATII cells
* Aging
* Cellular senescence
* IPF
* WNT signaling
|full-text-url=https://sci-hub.do/10.1016/j.cellsig.2020.109588
}}
==WNT7A==
 
{{medline-entry
|title=Exogenous Expression of [[WNT7A]] in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436833
 
 
|keywords=* WNT signaling
* WNT7A
* cell cycle
* chemotherapeutic agents
* leukemias
* senescence
|full-text-url=https://sci-hub.do/10.2174/1871520620666200521114100
}}
==WRN==
 
{{medline-entry
|title=The Impact of Vitamin C on Different System Models of Werner Syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202145
 
 
|keywords=* Werner syndrome
* aging
* mouse
* stem cells
* vitamin C
* worm
|full-text-url=https://sci-hub.do/10.1089/ars.2020.8147
}}
{{medline-entry
|title=[[WRN]] modulates translation by influencing nuclear mRNA export in HeLa cancer cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33054770
 
 
|keywords=* Cancer
* NXF1 export receptor
* Senescence
* Translation
* Werner syndrome protein
* mRNA export
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557079
}}
{{medline-entry
|title=MIB1-mediated degradation of [[WRN]] promotes cellular senescence in response to camptothecin treatment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652764
 
 
|keywords=* CPT
* Mind bomb 1
* Werner syndrome protein
* aging
* protein stability
|full-text-url=https://sci-hub.do/10.1096/fj.202000268RRR
}}
{{medline-entry
|title=A Case Report of Werner's Syndrome With a Novel Mutation From India.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32528764
 
 
|keywords=* aging
* novel mutation
* progeria
* werner syndrome
* wrn gene
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282380
}}
{{medline-entry
|title=Evidence for premature aging in a Drosophila model of Werner syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518666
 
|mesh-terms=* Aging, Premature
* Animals
* Behavior, Animal
* Body Composition
* Body Weight
* DNA Repair
* Drosophila
* Drosophila Proteins
* Exonucleases
* Female
* Gastrointestinal Neoplasms
* Male
* Motor Activity
* Muscle Weakness
* Mutation
* Phenotype
* Werner Syndrome
|keywords=* Aging
* DNA repair
* Locomotor function
* Tumor
* Werner syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935377
}}
==WT1==
 
{{medline-entry
|title=Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31602307
 
 
|keywords=* Backfat
* Gilts
* Leptin
* Litter performance
* Longevity
* Mating
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778857
}}
==WWP1==
 
{{medline-entry
|title=The ubiquitin ligase [[WWP1]] contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32822210
 
|mesh-terms=* Age Factors
* Animals
* Cells, Cultured
* Diastole
* Disease Models, Animal
* Extracellular Matrix
* Female
* Fibroblasts
* Heart Failure
* Hypertrophy, Left Ventricular
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Myocardium
* Phenotype
* Proteolysis
* Stroke Volume
* Ubiquitin-Protein Ligases
* Ventricular Dysfunction, Left
* Ventricular Function, Left
* Ventricular Remodeling
|keywords=* aging
* cardiac hypertrophy
* diastolic dysfunction
* heart failure
* ventricular remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717125
}}
==XBP1==
 
{{medline-entry
|title=Age-dependent impairment of adipose-derived stem cells isolated from horses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900232
 
 
|keywords=* Aging
* Endoplasmic reticulum stress
* Equine adipose-derived mesenchymal stem cells
* Insulin resistance
* Pro-inflammatory cytokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942290
}}
==XDH==
 
{{medline-entry
|title=Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32162142
 
 
|keywords=* Allantoin
* Reactive oxygen species
* Rice (Oryza sativa L.)
* Senescence
* Xanthine dehydrogenase
* Yield
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065298
}}
==ZC3H12A==
 
{{medline-entry
|title=Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786670
 
|mesh-terms=* Aging
* Animals
* Calgranulin A
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cornified Envelope Proline-Rich Proteins
* Epidermis
* Gene Expression Regulation
* Gene Ontology
* Inflammation
* Interleukin-1
* Keratinocytes
* Keratins
* Lymph Nodes
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Proliferating Cell Nuclear Antigen
* Ribonucleases
* Skin
* Spleen
* Transcriptome
|keywords=* MCPIP1
* Regnase-1
* Skin inflammation
* ZC3H12A
|full-text-url=https://sci-hub.do/10.1007/s00109-019-01853-2
}}
==ZEB2==
 
{{medline-entry
|title=miR-200b regulates cellular senescence and inflammatory responses by targeting [[ZEB2]] in pulmonary emphysema.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32070140
 
|mesh-terms=* Animals
* Cell Line
* Cellular Senescence
* Disease Models, Animal
* Gene Expression
* Gene Expression Regulation
* Inflammation
* Lung
* Mice
* MicroRNAs
* Pulmonary Emphysema
* Zinc Finger E-box Binding Homeobox 2
|keywords=* ZEB2
* cellular senescence
* inflammation
* miR-200b
* pulmonary emphysema
|full-text-url=https://sci-hub.do/10.1080/21691401.2020.1725029
}}
==ZMPSTE24==
 
{{medline-entry
|title=Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31666429
 
|mesh-terms=* Bone Marrow Cells
* Cell Cycle
* Cell Proliferation
* Cell Survival
* Cells, Cultured
* Cellular Senescence
* Coculture Techniques
* Collagen Type II
* Female
* Humans
* Intervertebral Disc Degeneration
* Male
* Matrix Metalloproteinase 9
* Membrane Proteins
* Mesenchymal Stem Cells
* Metalloendopeptidases
* Middle Aged
* Nucleus Pulposus
* Signal Transduction
* Transcription Factor RelA
* Up-Regulation
* beta-Galactosidase
|keywords=* 3D co-culture
* ZMPSTE24
* bone marrow-derived mesenchymal stem cells
* nucleus pulposus
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834418
}}

Текущая версия от 18:03, 26 марта 2021


A2M[править]

Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin.


MeSH Terms

  • Adult
  • Aging
  • Electrophoresis, Gel, Two-Dimensional
  • Glycosylation
  • Humans
  • Infant, Newborn
  • Polysaccharides
  • Pregnancy-Associated alpha 2-Macroglobulins
  • Protein Isoforms
  • Umbilical Cord

Keywords

  • Alpha-2-macroglobulin
  • Glycosylation
  • Newborn
  • Plasma

AACS[править]

Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study.


Keywords

  • aging
  • longitudinal studies
  • normative
  • self-report
  • sex characteristics

ABCG2[править]

Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†.


Keywords

  • cellular senescence
  • embryo receptivity
  • endometrial stem cell
  • human endometrial stromal cell
  • infertility


ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.


MeSH Terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • Aged
  • Aged, 80 and over
  • Aging
  • Cardiovascular Diseases
  • China
  • Cohort Studies
  • Effect Modifier, Epidemiologic
  • Epistasis, Genetic
  • Female
  • Genes, Modifier
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Glucose Transport Proteins, Facilitative
  • Humans
  • Hyperuricemia
  • Independent Living
  • Male
  • Neoplasm Proteins
  • Organic Anion Transporters
  • Organic Cation Transport Proteins
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Uric Acid

Keywords

  • ABCG2
  • Hypertension
  • Polymorphisms
  • Triglyceridemia
  • Uric acid

ABL1[править]

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.


MeSH Terms

  • Aniline Compounds
  • Antineoplastic Agents
  • Clinical Decision-Making
  • Consensus Development Conferences as Topic
  • Dasatinib
  • Disease Management
  • Fusion Proteins, bcr-abl
  • Gene Expression
  • Humans
  • Imatinib Mesylate
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Life Expectancy
  • Monitoring, Physiologic
  • Nitriles
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Quality of Life
  • Quinolines
  • Survival Analysis

ABO[править]

Allelic distribution of [i]ABO[/i] gene in Chinese centenarians.


Keywords

  • ABO gene
  • centenarian
  • longevity
  • single nucleotide polymorphisms


Genetically Determined ABO Blood Group and its Associations With Health and Disease.


MeSH Terms

  • ABO Blood-Group System
  • Adult
  • Age Factors
  • Aged
  • Cardiovascular Diseases
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Health Status
  • Healthy Aging
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • United Kingdom

Keywords

  • ABO
  • aging
  • blood
  • genetics
  • hypertension
  • phenotype

ABR[править]

[Hidden hearing loss and early identification].


MeSH Terms

  • Acoustic Stimulation
  • Audiometry, Pure-Tone
  • Auditory Threshold
  • Evoked Potentials, Auditory, Brain Stem
  • Hearing Loss, Noise-Induced
  • Humans
  • Noise

Keywords

  • aging
  • drug damage
  • hidden hearing loss
  • noise exposure


Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice.


Keywords

  • age-related hearing loss
  • aging
  • mouse primary auditoy cortex
  • parvalbumin


Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet.


MeSH Terms

  • Aging
  • Animals
  • Apolipoproteins E
  • Apoptosis
  • Diet, Western
  • Disease Models, Animal
  • Hearing Loss
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neurons
  • Spiral Ganglion

Keywords

  • Apoptosis
  • Atherosclerosis
  • Hearing loss
  • Reactive oxygen specie
  • Spiral ganglion neurons


Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Caenorhabditis elegans Proteins
  • Cochlea
  • Evoked Potentials, Auditory, Brain Stem
  • Fatty Acid Desaturases
  • Fatty Acids, Omega-3
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons
  • Presbycusis
  • Spiral Ganglion

Keywords

  • Age-related hearing loss
  • C57BL/6 mouse
  • Cochlea
  • Omega-3 (n-3) fatty acids


Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.


MeSH Terms

  • Aging
  • Animals
  • Cochlea
  • Evoked Potentials, Auditory, Brain Stem
  • Genotype
  • Hearing
  • Hearing Loss
  • Inflammation
  • Male
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Neovascularization, Pathologic
  • Neurons
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Proteome
  • Proto-Oncogene Proteins c-fos


Global nurse/midwife workforce and reproductive health through social ecology lens.


MeSH Terms

  • Adolescent
  • Cross-Sectional Studies
  • Employment
  • Female
  • Global Health
  • Health Education
  • Humans
  • Income
  • Life Expectancy
  • Male
  • Midwifery
  • Pregnancy
  • Reproductive Health
  • Social Environment
  • Socioeconomic Factors
  • Workforce

Keywords

  • global health
  • nurse/midwife workforce
  • reproductive health
  • social ecology

ACD[править]

Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Brazil
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

ACE[править]

Elite swimmers possess shorter telomeres than recreationally active controls.


Keywords

  • Aging
  • Athlete
  • Exercise
  • Genetics


Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.


Keywords

  • ACE2
  • ACEIs
  • ARBs
  • COVID-19
  • RAS
  • SARS-CoV-2
  • geriatrics
  • neuropsychiatric disorders


Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension.


Keywords

  • aging
  • endothelin
  • menopause
  • nitric oxide
  • renin-angiotensin system


Heart failure is associated with accelerated age related metabolic bone disease.


Keywords

  • Heart failure
  • comorbidities
  • geriatrics
  • metabolic bone disease
  • osteoporosis


Management of heart failure: an Italian national survey on fellows/specialists in geriatrics.


MeSH Terms

  • Aged
  • Geriatrics
  • Heart Failure
  • Humans
  • Italy
  • Specialization
  • Stroke Volume
  • Surveys and Questionnaires

Keywords

  • Aged, 65 years or over
  • Care survey
  • Health
  • Heart failure


Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Genetic Variation
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A
  • Peru
  • Polymorphism, Genetic

Keywords

  • ACE gene
  • Longevity
  • Perú
  • ageing


COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Antiviral Agents
  • Azithromycin
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Dipeptidyl Peptidase 4
  • Humans
  • Hydroxychloroquine
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Quercetin
  • Receptors, Virus
  • SARS-CoV-2

Keywords

  • Azithromycin
  • COVID-19
  • Doxycycline
  • Hydroxy-chloroquine
  • Quercetin
  • Rapamycin
  • aging
  • antibiotic
  • corona virus
  • drug repurposing
  • prevention
  • senescence
  • senolytic drug therapy
  • viral replication


[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The ACES Trial): Study Protocol of a Randomized Controlled Trial.


Keywords

  • aging
  • antihypertensive
  • exercise
  • functional status
  • hypertension


Vascular age.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Angiotensin-Converting Enzyme Inhibitors
  • Atherosclerosis
  • Child
  • Elasticity
  • Humans
  • Middle Aged
  • Perindopril
  • Pulse Wave Analysis
  • Vascular Stiffness
  • Young Adult

Keywords

  • ACE inhibitors
  • CT angiography
  • atorvastatin
  • dyslipidemia
  • hypertension
  • intima media thickness (IMT)
  • perindopril
  • pulse wave velocity (PWV)
  • statins
  • vascular age

ACE2[править]

How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis.


Keywords

  • ACE2
  • Alzheimer disease
  • Ang(1-7)/Mas
  • COVID-19
  • RAAS
  • SARS-CoV
  • brain aging
  • neurodegenerative and psychiatric disorders abstract


Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus
  • Binding Sites
  • COVID-19
  • Carrier Proteins
  • Computational Biology
  • Coronavirus Infections
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Ontology
  • Humans
  • Interferons
  • Lung
  • Male
  • Metalloproteases
  • Neovascularization, Physiologic
  • Organ Specificity
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Receptors, Virus
  • Renin-Angiotensin System
  • SARS-CoV-2
  • Sex Characteristics
  • Single-Cell Analysis
  • Transcription Factors
  • Transcription Initiation Site
  • Virus Attachment


A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections
  • Disease Models, Animal
  • Female
  • Forkhead Transcription Factors
  • Humans
  • Interferon-alpha
  • Interferons
  • Interleukins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Models, Molecular
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Receptors, Virus
  • SARS-CoV-2
  • Viral Vaccines


COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?


Keywords

  • acetyl-carnosine
  • aging
  • carnosine
  • inflammation
  • lungs
  • olfaction
  • virus


The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Angiotensin-Converting Enzyme 2
  • Anti-Inflammatory Agents
  • Betacoronavirus
  • COVID-19
  • Child
  • Child, Preschool
  • Coronavirus
  • Coronavirus Infections
  • Female
  • Geriatrics
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Pandemics
  • Pediatrics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Protein Binding
  • Receptors, Virus
  • Renin-Angiotensin System
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome
  • Virus Internalization

Keywords

  • ACE2
  • Angiotensin 2
  • Angiotensin-(1–7)
  • Corona virus
  • Glycoprotein spikes
  • RAAS system


The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging".


MeSH Terms

  • Adipocytes
  • Age Factors
  • Aged
  • Aging
  • Angiotensin II Type 2 Receptor Blockers
  • Autophagy
  • Betacoronavirus
  • COVID-19
  • Cellular Senescence
  • Coronavirus Infections
  • Cytokine Release Syndrome
  • Cytokines
  • Humans
  • Immune System
  • Inflammation
  • Pandemics
  • Pneumonia, Viral
  • Reactive Oxygen Species
  • Receptor, Angiotensin, Type 2
  • SARS-CoV-2
  • Vitamin D
  • Vitamin D Deficiency

Keywords

  • ACE2 receptor
  • Autophagy
  • COVID-19
  • Cytokine storm
  • Senescent cell
  • Vitamin D


Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis.


MeSH Terms

  • Adaptive Immunity
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • DNA, Mitochondrial
  • Gene Expression Regulation, Viral
  • Host Microbial Interactions
  • Humans
  • Immunity, Innate
  • Mitochondria
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA, Viral
  • SARS-CoV-2
  • Virus Replication

Keywords

  • COVID-19
  • SARS-CoV
  • aging
  • coronavirus
  • mitochondria
  • mitochondrial DNA


A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.


MeSH Terms

  • Aging
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • Brain
  • COVID-19
  • CRISPR-Cas Systems
  • Coronavirus Infections
  • Cytokines
  • Disease Models, Animal
  • Gene Knock-In Techniques
  • Lung
  • Lung Diseases, Interstitial
  • Mice, Inbred C57BL
  • Nose
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA, Viral
  • SARS-CoV-2
  • Stomach
  • Trachea
  • Viral Load
  • Virus Replication

Keywords

  • SARS-CoV-2
  • angiotensin-converting enzyme II
  • hACE2-KI/NIFDC
  • mouse model
  • pathogenesis


COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.


MeSH Terms

  • Age Factors
  • Aged
  • Betacoronavirus
  • COVID-19
  • Cardiovascular Diseases
  • Coronavirus Infections
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Risk Factors
  • SARS-CoV-2

Keywords

  • Acute myocardial injury
  • Aging
  • COVID-19
  • Cardiovascular system
  • Frailty
  • SARS-CoV-2


Gut microbiota and Covid-19- possible link and implications.


MeSH Terms

  • Aging
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Diet
  • Dysbiosis
  • Gastrointestinal Microbiome
  • Gastrointestinal Tract
  • Homeostasis
  • Humans
  • Immunity
  • Lung
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2

Keywords

  • Covid-19
  • Diet
  • Dysbiosis
  • Gut microbiome
  • Immunity
  • Lung microbiota
  • SARS-CoV-2


Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Antibodies, Monoclonal, Humanized
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Humans
  • Inflammation
  • Interferon Type I
  • Interleukin-6
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome

Keywords

  • COVID-19
  • Cardiovascular diseases
  • Host-directed therapies
  • Inflamm-aging
  • SARS-CoV-2
  • interleukin-6


Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.


Keywords

  • aging
  • cardiac hypertrophy index
  • intermittent fasting
  • renin–angiotensin system (RAS)


Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in ACE2-knockout mice.


MeSH Terms

  • Adipose Tissue
  • Aging
  • Angiotensin I
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Body Weight
  • Bone Resorption
  • Cyclin-Dependent Kinase Inhibitor p16
  • Forelimb
  • Gene Deletion
  • Hand Strength
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle Weakness
  • Muscles
  • Organ Size
  • PAX3 Transcription Factor
  • Peptide Fragments
  • Peptidyl-Dipeptidase A
  • Proto-Oncogene Proteins
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Time Factors

Keywords

  • Angiotensin 1-7
  • Angiotensin Converting Enzyme 2
  • Mas receptor
  • Muscle weakness
  • osteoporosis

ACLY[править]

In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.


Keywords

  • Aging
  • Apoptosis/necrosis
  • Caloric restriction mimetics
  • Hydroxycitric acid
  • Oxidative stress
  • Sch9 and Ras2 pathways

ACR[править]

Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.


Keywords

  • p16
  • primary Sjögren’s syndrome
  • salivary gland
  • salivary gland progenitor cells
  • senescence


Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.


Keywords

  • Aging
  • Jumping mechanography
  • Muscle
  • Osteoarthritis
  • Sarcopenia

ACVR1[править]

Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome.


Keywords

  • ACVR1
  • activin A
  • cell senescence
  • fibrodysplasia ossificans progressiva
  • progeroid syndrome

ADA[править]

Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging.


Keywords

  • adenosine metabolism
  • aging
  • animal models
  • glutamate
  • purinergic signaling

ADAM10[править]

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10.


Keywords

  • ADAM10
  • NKG2D
  • NKG2D ligands
  • cancer
  • chemotherapy
  • senescence
  • shedding


Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice.


MeSH Terms

  • ADAM10 Protein
  • Aging
  • Amyloid Precursor Protein Secretases
  • Animals
  • Cognition
  • Epigenesis, Genetic
  • Female
  • Glial Fibrillary Acidic Protein
  • Glycogen Synthase Kinase 3 beta
  • Mechanistic Target of Rapamycin Complex 1
  • Membrane Proteins
  • Mice
  • MicroRNAs
  • NF-kappa B
  • Reactive Oxygen Species
  • Signal Transduction
  • Stress, Psychological

Keywords

  • Alzheimer’s disease
  • SAMP8
  • SAMR1
  • age-related cognitive decline
  • autophagy
  • cognition
  • epigenetics
  • inflammation
  • oxidative stress
  • senescence
  • stress

ADAM17[править]

ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.


MeSH Terms

  • ADAM17 Protein
  • Aged
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Humans
  • Male
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Receptors, Interleukin-6
  • Risk Factors
  • SARS-CoV-2
  • Serine Endopeptidases
  • Tumor Necrosis Factor-alpha

Keywords

  • ACE2
  • ADAM17
  • COVID-19 pathophysiology
  • SARS-CoV-2
  • TMPRSS2

ADH5[править]

Can Serum Nitrosoproteome Predict Longevity of Aged Women?


Keywords

  • aging
  • cardiovascular disease
  • muscle atrophy
  • nitrosative stress
  • proteomics

ADM[править]

Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach.


Keywords

  • Aging
  • Decomposition-based quantitative electromyography (DQEMG)
  • Hand muscle
  • Jiggle
  • Motor unit potential (MUP)
  • Multivariate


Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging.


Keywords

  • ADM system
  • Aging
  • Biomarkers
  • ET-1system
  • LncRNA
  • NP system

ADORA2B[править]

Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss.


Keywords

  • ADA-deficiency
  • adenosine deaminase deficiency
  • aging
  • myelin protein zero
  • myelination

ADRA2A[править]

α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway.


Keywords

  • ADRA2A
  • PI3K/Akt/mTOR pathway
  • cervical cancer
  • metastasis
  • proliferation
  • senescence

AFM[править]

Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy (AFM-IR) for nanoscale chemical characterization.


Keywords

  • AFM-IR
  • Aging process
  • Microplastics
  • Nanoscale characterization
  • Polypropylene


Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy (AFM-IR) technique.


Keywords

  • AFM-IR
  • Aging process
  • Mechanical properties
  • Microplastics (MPs)
  • Thermal analysis


Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope.


Keywords

  • AFM
  • Air plasma treatment
  • Liquid aging
  • PDMS
  • Zeta potential


Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review.


Keywords

  • AFM-IR
  • blends
  • nanoscale characterization
  • polymer aging
  • polymer composites
  • polymers


Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.


Keywords

  • AFM, active fraction of mannoproteins
  • ALP, alkaline phosphatase
  • ALT, alanine aminotransferase
  • Ageing
  • CBC, complete blood count
  • CD21+, B lymphocyte
  • CD4+, auxiliary T lymphocyte
  • CD5+, total T lymphocyte
  • CD8+, cytotoxic lymphocyte
  • CO, cells only
  • Canine
  • DCHT, delayed cutaneous hypersensitivity test
  • FOSs, fructooligosaccharides
  • GALT, gut-associated lymphoid tissue
  • IL-12, interleukin 12
  • IgA, immunoglobulin A
  • Immunosenescence
  • LPS, bacterial lipopolysaccharide
  • MOSs, mannanoligosaccharides
  • NADPH, reduced nicotinamide adenine dinucleotide phosphate
  • NO, nitrogen monoxide
  • NOS, nitric oxide synthase
  • OD, optical density
  • PMA, phorbol myristate acetate
  • Saccharomyces cerevisiae
  • Senescence
  • TNF-α, tumour necrosis factor alpha
  • Th1, helper T lymphocyte


The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt.


Keywords

  • Fourier transform infrared spectroscopy
  • atomic force microscopy
  • gel permeation chromatography
  • ultraviolet aging
  • waste engine oil
  • waste polyethylene


Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.


MeSH Terms

  • Aging
  • Animal Feed
  • Animals
  • Bacillus subtilis
  • Biomarkers
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Comamonas
  • Escherichia coli
  • Forkhead Transcription Factors
  • Hot Temperature
  • Insulin
  • Microbiota
  • Microscopy, Atomic Force
  • Mutation
  • Receptor, Insulin
  • Signal Transduction
  • Ultraviolet Rays


Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Biomechanical Phenomena
  • Brain
  • Cell Culture Techniques
  • Cell Membrane
  • Cellular Senescence
  • Endothelial Cells
  • Endothelium, Vascular
  • Humans
  • Microscopy, Atomic Force
  • Vascular Endothelial Growth Factor A

Keywords

  • Amyloid beta oligomer
  • Atomic force microscopy
  • Brain endothelial cells
  • Nanoindentation
  • Nanomechanical properties
  • Senescence

AGER[править]

Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Cell Proliferation
  • Cholecalciferol
  • Down-Regulation
  • Galactose
  • Male
  • Oxidative Stress
  • Rats
  • Spermatogenesis
  • Testis

AGT[править]

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.


Keywords

  • Aging
  • SQSTM1
  • autophagy
  • oxidative stress
  • senescence
  • vascular biology

AHR[править]

Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging.


MeSH Terms

  • Aging
  • Animals
  • Bacteria
  • Cell Differentiation
  • Epithelial Cells
  • Female
  • Goblet Cells
  • Indoles
  • Interleukin-10
  • Interleukins
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microbiota
  • Mucus
  • Receptors, Aryl Hydrocarbon
  • Signal Transduction

Keywords

  • aging
  • goblet cell
  • intestinal homeostasis
  • mucus


Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis.


MeSH Terms

  • Animals
  • Environmental Exposure
  • Extracellular Matrix
  • Humans
  • Receptors, Aryl Hydrocarbon
  • Skin Aging
  • Skin Neoplasms

Keywords

  • DNA damage
  • UV radiation
  • extracellular matrix
  • extrinsic skin aging
  • melanoma
  • particulate matter
  • pigmentation
  • polycyclic aromatic hydrocarbons
  • squamous cell carcinoma

AIP[править]

[Aryl hydrocarbon receptor interacting protein (AIP) in human dermis during aging.]


Keywords

  • AIP
  • PCNA
  • aging
  • fibroblasts
  • skin


Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.


Keywords

  • atherogenic index of plasma
  • dyslipidaemia
  • gerontology
  • sex difference
  • vitamin D


The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults.


MeSH Terms

  • Aged
  • Brain
  • Cognition
  • Connectome
  • Diffusion Tensor Imaging
  • Executive Function
  • Female
  • Humans
  • Judgment
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Pattern Recognition, Visual
  • Spatial Processing

Keywords

  • Aging
  • Executive function
  • Oblique effect
  • Perception
  • Structural connectivity
  • Visuospatial processing

ALAS1[править]

Heterozygous disruption of ALAS1 in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver.


Keywords

  • 5-Aminolevulinate synthase 1 (ALAS1)
  • 5-Aminolevulinic acid (ALA)
  • Aging
  • Free heme
  • Liver
  • Skeletal muscle

ALB[править]

Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats.


Keywords

  • M/L ratio
  • SAA
  • aging
  • domestic cats
  • obesity

ALK[править]

Catalog of Lung Cancer Gene Mutations Among Chinese Patients.


Keywords

  • China
  • aging
  • gene mutation
  • lung cancer
  • pathology
  • tobacco smoking

ALKBH8[править]

Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming .


MeSH Terms

  • AlkB Homolog 8, tRNA Methyltransferase
  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Epigenesis, Genetic
  • Gene Deletion
  • Gene Expression Profiling
  • Humans
  • Mice
  • Mitochondria
  • Oxygen Consumption
  • Selenocysteine
  • Uncoupling Protein 2

Keywords

  • Epitranscriptome
  • Mitochondria
  • Selenium
  • Senescence
  • Uncoupling protein

ALOX12[править]

Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer.


Keywords

  • aging
  • arachidonic acid (AA) (ARA)
  • cancer biology
  • cell proliferation
  • fibroblast
  • pancreatic cancer
  • stromal cell

ALOX5[править]

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.


MeSH Terms

  • Aging
  • Alanine
  • Animals
  • Arachidonate 5-Lipoxygenase
  • Asparagine
  • Body Weight
  • Female
  • Gene Knock-In Techniques
  • Leukotrienes
  • Linoleic Acid
  • Male
  • Mice
  • Mutation
  • PPAR gamma
  • Phenylalanine

Keywords

  • eicosanoids
  • inflammation
  • leukotrienes
  • lipoxygenase
  • resolvins

AMH[править]

Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.


Keywords

  • STRAW
  • adolescent and young adult cancer
  • menopausal transition
  • premature ovarian insufficiency
  • reproductive aging


Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.


Keywords

  • Cardiometabolic Risk
  • HIV
  • Menopause
  • Reproductive Aging
  • Sex
  • Women


Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield.


Keywords

  • Aging
  • DNA methylation
  • Epigenetic clock
  • Epigenetics
  • Infertility
  • Methylome
  • Ovarian aging


Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH.


Keywords

  • AMH
  • adolescent and young adult cancer
  • functional principal components analysis
  • ovarian reserve
  • reproductive lifespan


Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study.


Keywords

  • Tehran Lipid and Glucose Study (TLGS)
  • anti-müllerian hormone (AMH)
  • menopause
  • reproductive aging


Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.


Keywords

  • aging
  • female reproductive endocrinology
  • gonadotropins
  • inhibin/activin/follistatin/AMH
  • menopause
  • ovaries


Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary.


MeSH Terms

  • Aging
  • Animals
  • Anti-Mullerian Hormone
  • Antigens, Ly
  • Cell Differentiation
  • Cell Shape
  • Female
  • Lewis X Antigen
  • Membrane Proteins
  • Mice, Inbred C57BL
  • Ovary
  • Stem Cells

Keywords

  • BMP-4
  • Multipotent
  • Ovary
  • Retinoic acid
  • Stem cells


Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Anti-Mullerian Hormone
  • Child
  • Child, Preschool
  • Female
  • Fertility Preservation
  • Humans
  • Ovarian Follicle
  • Retrospective Studies
  • Young Adult

Keywords

  • anti-Müllerian hormone
  • cancer
  • fertility preservation
  • ovarian reserve
  • ovarian tissue
  • primary follicle
  • primordial follicle


Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.


MeSH Terms

  • Adult
  • Anti-Mullerian Hormone
  • Biomarkers
  • Body Mass Index
  • Cardiovascular Diseases
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infertility, Female
  • Polycystic Ovary Syndrome
  • Prognosis
  • United States

Keywords

  • anti-mullerian hormone (AMH)
  • cardiometabolic health
  • cardiovascular risk
  • ovarian aging
  • ovarian reserve markers
  • reproductive aging


Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares.


MeSH Terms

  • Aging
  • Animals
  • Anti-Mullerian Hormone
  • Female
  • Fertility
  • Horses
  • Ovarian Follicle
  • Ovulation

Keywords

  • AMH
  • Anzahl Follikel
  • Ovar
  • Pferd
  • Ultraschall
  • compte folliculaire
  • conta dei follicoli
  • ecografia
  • equine
  • equini
  • follicle count
  • ovaia
  • ovaire
  • ovary
  • reproductive status
  • stato riproduttivo
  • ultrasonography
  • ­Reproduktionsstatus
  • échographie
  • équin
  • état reproducteur

AMT[править]

A multi-method comparison of autobiographical memory impairments amongst younger and older adults.


Keywords

  • Depression
  • aging
  • episodic memory
  • overgeneral
  • specificity

ANGPTL2[править]

Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study.


MeSH Terms

  • Aged
  • Angiopoietin-like Proteins
  • Biomarkers
  • C-Reactive Protein
  • Disease Progression
  • Female
  • Humans
  • Kidney Diseases
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Renal Dialysis
  • Risk Factors
  • Survival Rate

Keywords

  • aging
  • angiopoietin-like protein (ANGPTL) 2
  • chronic inflammation
  • hemodialysis
  • mortality risk

ANK3[править]

Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.


Keywords

  • ANK3
  • Aging
  • Cortical thickness
  • Major depressive disorder
  • Neuroimage

AOX1[править]

N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin?


Keywords

  • AMPK
  • MNAM
  • Ovarian Aging
  • ROS

AP2B1[править]

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.


MeSH Terms

  • Adaptor Protein Complex beta Subunits
  • Aging
  • Alzheimer Disease
  • Animals
  • Astrocytes
  • Autophagy
  • Cellular Senescence
  • Dynamin I
  • Genes, Neurofibromatosis 1
  • Mice
  • RNA, Circular
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • aging
  • astrocyte
  • autophagy
  • biological function
  • circular RNA

APC[править]

Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014.


MeSH Terms

  • Adult
  • African Americans
  • Aged
  • Behavior
  • Cohort Studies
  • Emotions
  • European Continental Ancestry Group
  • Female
  • Hispanic Americans
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Socioeconomic Factors
  • Survival Analysis
  • United States


Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.


Keywords

  • Compliance
  • Senescence
  • Stem Cell


Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017.


MeSH Terms

  • Female
  • Global Burden of Disease
  • Global Health
  • Humans
  • Iran
  • Life Expectancy
  • Male
  • Musculoskeletal Diseases
  • Quality-Adjusted Life Years

Keywords

  • Burden
  • DALY
  • Decomposition
  • Global burden of diseases
  • Iran
  • Musculoskeletal diseases


Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Female
  • Geriatrics
  • Health Policy
  • Health Services Needs and Demand
  • Humans
  • Japan
  • Male
  • Mortality
  • Public Health

Keywords

  • adult intensive & critical care
  • epidemiology
  • geriatric medicine
  • health & safety
  • health policy
  • public health


Stroke Mortality Rates and Trends in Romania, 1994-2017.


MeSH Terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Female
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Prognosis
  • Registries
  • Risk Assessment
  • Risk Factors
  • Romania
  • Sex Distribution
  • Stroke
  • Time Factors

Keywords

  • Mortality
  • age-standardized mortality rates
  • life expectancy
  • stroke


A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking.


MeSH Terms

  • Accelerometry
  • Adult
  • Aged
  • Aging
  • Electroencephalography
  • Evoked Potentials
  • Exercise Test
  • Female
  • Gait
  • Humans
  • Male
  • Middle Aged
  • Multitasking Behavior
  • Reaction Time
  • Walking

Keywords

  • Dual task
  • EEG
  • Gait cycle
  • Gait related potentials (GRP)

APOC3[править]

Positional Obstructive Sleep Apnea Syndrome in Elderly Patients.


MeSH Terms

  • Adult
  • Aged
  • Humans
  • Middle Aged
  • Polysomnography
  • Posture
  • Prospective Studies
  • Sleep Apnea, Obstructive
  • Supine Position
  • Young Adult

Keywords

  • aging effects
  • obstructive sleep apnea
  • polysomnography
  • positional sleep apnea

APOE[править]

Polygenic risk score of longevity predicts longer survival across an age-continuum.


Keywords

  • centenarians
  • cognitive health
  • genetics
  • healthy aging
  • longevity


Association Between APOE Alleles and Change of Neuropsychological Tests in the Long Life Family Study.


Keywords

  • APOE
  • cognition
  • longevity
  • longitudinal studies


The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.


Keywords

  • Alzheimer's disease
  • aging
  • air pollution
  • apolipoprotein E
  • chromosome 19q13


Homozygosity in the [i]APOE[/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.


Keywords

  • APOE E3
  • Chinese
  • aging
  • depressive symptom
  • schizophrenia


Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort.


Keywords

  • Cognition
  • ageing
  • apolipoprotein E
  • brain
  • lifespan


Cardiovascular risk factors and APOE-ε4 status affect memory functioning in aging via changes to temporal stem diffusion.


Keywords

  • APOE
  • BMI
  • RRID:SCR_001398
  • RRID:SCR_002403
  • RRID:SCR_002823
  • RRID:SCR_002865
  • RRID:SCR_007037
  • aging
  • diffusion tensor imaging
  • hypertension
  • memory
  • path modeling


APOE [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults.


Keywords

  • APOE ε4 differences
  • brain aging
  • dementia
  • neuroimaging
  • racial/ethnic differences
  • resting‐state functional connectivity


Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.


Keywords

  • Cognitive aging
  • Epidemiology
  • Olfactory
  • Olfactory impairment


When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2.


Keywords 

         APOE
  • Age beliefs
  • Cognition
  • Gene
  • Health and Retirement Study
  • Self-perceptions of aging


Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Apolipoprotein E4
  • Biomarkers
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged


Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study.


Keywords

  • Aging
  • Alzheimer’s disease
  • Dementia
  • Dementia prevention
  • Modifiable risk factors
  • Population attributable fraction
  • Public health


Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study.


Keywords

  • Biomarkers
  • Brain aging
  • Cognitive aging
  • Machine learning


Effects of an APOE Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging.


Keywords

  • APOE promoter
  • aging
  • brain connectome
  • fronto-parietal network
  • working memory


The relationship of parental longevity with the aging brain-results from UK Biobank.


Keywords

  • Aging
  • Brain structure
  • DTI
  • MRI
  • Neuroimaging
  • Parental longevity


Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.


Keywords

  • Alzheimer’s disease
  • aging
  • microglia
  • neurodegenerative diseases
  • neuroinflammation
  • transcriptomics


Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.


Keywords

  • APOEɛ4
  • Aging
  • Alzheimer’s disease
  • gender
  • lipid

species


Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Apolipoproteins E
  • Biomarkers
  • Cognition
  • Databases, Factual
  • Female
  • Genotype
  • Hippocampus
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Neuroimaging
  • Organ Size
  • Parenchymal Tissue
  • Reference Values
  • Sex Factors

Keywords

  • Alzheimer’s disease
  • Apolipoprotein E ϵ4
  • Atrophy
  • Brain
  • Healthy aging
  • Hippocampal parenchymal fraction
  • Hippocampal volumetric integrity
  • Hippocampus
  • MRI
  • Mild cognitive impairment
  • Neurodegeneration
  • Sex


Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO).


Keywords

  • Cilento Region
  • cognitive health
  • lifestyle
  • longevity


Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project.


Keywords

  • Aging
  • Alzheimer’s disease
  • Apolipoprotein E
  • Cognition
  • Cognitive frailty
  • Frailty
  • Male


CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Biomarkers
  • Cerebrovascular Disorders
  • Cognitive Dysfunction
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Peptide Fragments
  • White Matter
  • tau Proteins

Keywords

  • Alzheimer's disease
  • Amyloid
  • Cerebrospinal fluid
  • Tau
  • Vascular disease
  • White matter hyperintensities


Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.


Keywords

  • Aging
  • Alzheimer’s disease
  • blood pressure
  • cerebrovascular circulation
  • neuroimaging
  • obesity


Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Age Factors
  • Aging
  • Alzheimer Disease
  • Animals
  • Apolipoprotein E2
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E
  • Brain
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Gene Regulatory Networks
  • Genotype
  • Humans
  • Male
  • Membrane Glycoproteins
  • Membrane Proteins
  • Metabolome
  • Mice
  • Mice, Transgenic
  • Protective Factors
  • Receptors, Immunologic
  • Risk Factors
  • Serpins
  • Sex Factors
  • Unfolded Protein Response

Keywords

  • APOE
  • Alzheimer’s disease
  • Serpina3
  • age
  • extracellular vesicles
  • inflammation
  • lipid metabolism
  • metabolomics
  • sex
  • transcriptomics


Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Amyloidogenic Proteins
  • Apolipoproteins E
  • Brain
  • Cognition
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging
  • Organ Size
  • Personality
  • Positron-Emission Tomography

Keywords

  • Amyloid load
  • Cognitive aging
  • Cohort studies
  • Personality
  • Structural MRI


Physical Activity as Moderator of the Association Between APOE and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies.


Keywords

  • Gene–environment interaction
  • InCHIANTI
  • Longitudinal Aging Study Amsterdam
  • Rotterdam Study


Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognition
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Prospective Studies


Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.


Keywords

  • APOE ε4
  • Aging
  • Cerebral blood flow
  • Cognitive decline
  • Cortical thickness


Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alleles
  • Amyloidogenic Proteins
  • Apolipoprotein E4
  • Cognitive Reserve
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Longitudinal Studies
  • Male
  • Neuropsychological Tests
  • Organ Size
  • Positron-Emission Tomography
  • Sex Factors
  • Temporal Lobe

Keywords

  • APOE
  • Amyloid load
  • Cognitive changes
  • Mesial temporal lobe
  • Normal aging
  • Structural MRI


Long-term exposure to ambient air pollution, APOE-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan.


MeSH Terms

  • Aged
  • Air Pollutants
  • Air Pollution
  • Apolipoprotein E4
  • Apolipoproteins E
  • Cognitive Dysfunction
  • Female
  • Genotype
  • Humans
  • Male
  • Prospective Studies
  • Washington

Keywords

  • APOE-ε4 allele
  • Aging
  • Air pollution
  • Cognitive decline
  • Cognitive risk factors
  • Epidemiology


Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice.


MeSH Terms

  • Age of Onset
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Apolipoprotein E4
  • Apolipoproteins E
  • Brain
  • Disease Models, Animal
  • Female
  • Genotype
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Metabolome
  • Mice
  • Mice, Transgenic
  • Sex Characteristics
  • Sex Chromosomes


APOE region molecular signatures of Alzheimer's disease across races/ethnicities.


MeSH Terms

  • Alleles
  • Alzheimer Disease
  • Apolipoproteins E
  • Continental Population Groups
  • Haplotypes
  • Heterozygote
  • Homozygote
  • Humans
  • Linkage Disequilibrium
  • Polymorphism, Single Nucleotide
  • Risk Factors

Keywords

  • APOE polymorphism
  • Aging
  • Alzheimer's disease
  • Health span
  • Life span
  • Neurodegenerative disorders


Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.


MeSH Terms

  • Aged, 80 and over
  • Alleles
  • Apolipoproteins E
  • Ethnic Groups
  • Europe
  • European Continental Ancestry Group
  • Female
  • Humans
  • Longevity
  • Male

Keywords

  • APOE
  • Bioinformatics
  • Human genetics
  • Longevity


Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Anxiety
  • Apolipoprotein E4
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Depression
  • Efficiency
  • Female
  • Healthy Volunteers
  • Humans
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Neuropsychological Tests
  • Prospective Studies
  • Risk Factors
  • Sleep
  • United Kingdom
  • Work

Keywords

  • Alzheimer Disease
  • CHARIOT
  • aging registry
  • cognitive health
  • pre-clinical


Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans.


MeSH Terms

  • African Americans
  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Blood Flow Velocity
  • Cardiovascular Diseases
  • Cerebrovascular Circulation
  • European Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors

Keywords

  • African Americans
  • Alzheimer’s disease
  • Apolipoprotein E4
  • aging
  • cerebrovascular circulation
  • glucose
  • metabolic syndrome
  • neuroimaging
  • risk factors


Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?


Keywords

  • Alzheimers
  • Cognitive aging
  • Drug related
  • Medication


Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Amyloid
  • Biomarkers
  • Cohort Studies
  • Europe
  • Female
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Parkinson Disease
  • Sex Factors
  • tau Proteins

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid
  • Biomarker
  • Cerebrospinal fluid
  • Inflammation
  • Mild cognitive impairment
  • Multicenter
  • Parkinson's disease
  • Tau


Prospective Memory: Age related change is influenced by APOE genotype.


Keywords

  • APOE
  • Alzheimer’s disease
  • aging
  • mid-adulthood
  • prospective memory


Education Moderates the Relation Between APOE ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults.


MeSH Terms

  • Adult
  • African Americans
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Apolipoprotein E4
  • Cognitive Reserve
  • Educational Status
  • Executive Function
  • Female
  • Humans
  • Male
  • Memory
  • Memory, Episodic
  • Memory, Short-Term
  • Middle Aged
  • Neuropsychological Tests
  • Sex Characteristics

Keywords

  • APOE
  • African American
  • Alzheimer’s disease
  • cognitive reserve
  • educational attainment
  • episodic memory
  • genetic risk
  • neuropsychological evaluation


Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.


MeSH Terms

  • Age Factors
  • Aged
  • Alleles
  • Apolipoprotein E4
  • Cognition Disorders
  • European Continental Ancestry Group
  • Executive Function
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Memory
  • Neuropsychological Tests
  • Sex Factors

Keywords

  • Aging
  • Alzheimer's disease
  • Apolipoprotein E ε4
  • Cognitive decline
  • Sex


Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Apolipoprotein E4
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Myelin Sheath
  • White Matter

Keywords

  • Aging
  • Alzheimer
  • Apolipoprotein E
  • Cognitively normal subjects
  • Myelination
  • T1w/T2w ratio
  • White matter integrity


APOE modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Apolipoproteins E
  • Cerebral Cortex
  • Cerebrovascular Circulation
  • Entorhinal Cortex
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Memory
  • Middle Aged

Keywords

  • APOE ε4
  • Aging
  • Alzheimer’s disease
  • Cerebral blood flow
  • Cognitive decline
  • Cortical thickness


When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.


MeSH Terms

  • Adult
  • Alleles
  • Alzheimer Disease
  • Apolipoprotein E4
  • Cognition
  • Cognitive Aging
  • Female
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Memory
  • Memory, Episodic
  • Middle Aged
  • Young Adult

Keywords

  • Alzheimer's diseas
  • Apolipoprotein E
  • Cognition
  • Episodic memory
  • Semantic memory


Cognitive-Motor Integration Performance Is Affected by Sex, APOE Status, and Family History of Dementia.


MeSH Terms

  • Aged
  • Apolipoproteins E
  • Cognition
  • Cognitive Dysfunction
  • Cross-Sectional Studies
  • Dementia
  • Female
  • Humans
  • Male
  • Medical History Taking
  • Middle Aged
  • Photic Stimulation
  • Psychomotor Performance
  • Sex Characteristics
  • Surveys and Questionnaires

Keywords

  • Aging
  • alzheimer’s disease
  • apolipoprotein E4
  • dementia risk
  • geriatric

assessment

  • motor skills
  • movement
  • visuomotor integration


Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Amyloid beta-Peptides
  • Atrophy
  • Brain
  • Cognition
  • Cognitive Dysfunction
  • Databases, Factual
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid-β
  • Brain atrophy


Cognitive function and neuropathological outcomes: a forward-looking approach.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Cognitive Dysfunction
  • Female
  • Humans
  • Male
  • Middle Aged

Keywords

  • Alzheimer’s disease
  • Cognition
  • Multi-state model
  • Neuropathology


APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Apolipoprotein E3
  • Apolipoprotein E4
  • Apolipoproteins E
  • Breath Holding
  • Cerebrovascular Circulation
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Genotype
  • Hemodynamics
  • Humans
  • Longevity
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nitrates

Keywords

  • Ageing
  • Alzheimer's disease
  • Apolipoprotein E
  • BOLD fMRI
  • Breath-hold
  • Cerebrovascular reactivity

APP[править]

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Behavior, Animal
  • Cognitive Dysfunction
  • Cytokines
  • Dipeptides
  • Disease Models, Animal
  • Encephalitis
  • Female
  • Humans
  • Inflammation
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Serpins
  • Spatial Memory
  • Viral Proteins
  • para-Aminobenzoates


Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.


Keywords

  • aging
  • amyloid beta
  • dendritic spine
  • neuroinflammation
  • regorafenib
  • tau


An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis.


Keywords

  • aging
  • amyloid hypothesis
  • amyloid precursor protein homeostasis
  • late onset Alzheimer's disease
  • young onset Alzheimer's disease


Transcriptomic profiling of microglia and astrocytes throughout aging.


Keywords

  • Aging
  • Alzheimer’s disease (AD)
  • Astrocyte
  • Microglia
  • RNA-seq


Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.


Keywords

  • Alzheimer’s disease
  • aging
  • astrocytes
  • platelets
  • vascular pathology


CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Aspartic Acid Endopeptidases
  • Autophagy
  • Brain
  • Cognitive Dysfunction
  • Disease Models, Animal
  • Dopaminergic Neurons
  • Down-Regulation
  • Drosophila
  • Drosophila Proteins
  • Eye
  • Learning Disabilities
  • Locomotion
  • Longevity
  • Nuclear Proteins
  • Presenilins
  • RNA Interference
  • Wings, Animal

Keywords

CHIP

  • APP
  • Alzheimer’s disease
  • Aβ
  • autophagy


Studies on APP metabolism related to age-associated mitochondrial dysfunction in APP/PS1 transgenic mice.


MeSH Terms

  • Adenosine Triphosphate
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Blood Platelets
  • Disease Models, Animal
  • Hippocampus
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mitochondria
  • Presenilin-1

Keywords

  • APP/PS1 mice
  • Amyloid-beta
  • adenosine 5’-triphosphate
  • mitochondria dysfunction
  • platelets


Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.


MeSH Terms

  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Case-Control Studies
  • Cognition
  • Cognitive Dysfunction
  • Female
  • Humans
  • Hyperoxia
  • Hypoxia
  • Male
  • Middle Aged
  • Pilot Projects
  • Respiratory Therapy
  • Treatment Outcome

Keywords

  • Alzheimer’s disease
  • adaptation
  • aging
  • amyloid beta
  • biomarker
  • cognitive function
  • hyperoxia
  • intermittent hypoxia
  • platelets


The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides
  • Androgens
  • Aspartic Acid Endopeptidases
  • Cognition
  • Cognitive Dysfunction
  • Cyclic AMP Response Element-Binding Protein
  • Female
  • Hippocampus
  • Humans
  • Learning
  • MAP Kinase Signaling System
  • Male
  • Middle Aged
  • Neoplasm Proteins
  • Phosphorylation
  • Protein Kinase C
  • Receptors for Activated C Kinase
  • tau Proteins

Keywords

  • Androgens
  • Cognition
  • Hippocampus
  • Protein kinase C
  • Spatial memory


Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.


Keywords

  • Aging
  • Alaska pollack protein
  • Motor unit identification
  • Multichannel surface electromyography
  • Nutritional supplementation


Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Antipsychotic Agents
  • Asian Continental Ancestry Group
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polypharmacy
  • Schizophrenia

Keywords

  • Asian
  • antipsychotic polypharmacy
  • older adult patients
  • schizophrenia


A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.


MeSH Terms

  • Amyloid beta-Protein Precursor
  • Brain
  • Down Syndrome
  • Exosomes
  • Humans

Keywords

  • APP
  • APP-CTFs
  • Aging
  • Brain
  • Down syndrome
  • Exosomes
  • Extracellular vesicles

APPL1[править]

Insulin and adipokine signaling and their cross-regulation in postmortem human brain.


MeSH Terms

  • Adipokines
  • Aging
  • Brain
  • Humans
  • Insulin
  • Leptin
  • Postmortem Changes
  • Signal Transduction

Keywords

  • Adipokine
  • Adiponectin receptors
  • Alzheimer's disease–related dementias
  • Leptin receptors
  • Postmortem brain
  • Type 2 diabetes
  • insulin signaling

AQP3[править]

Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters.


Keywords

  • adipocytes
  • aging
  • cosmetics
  • face
  • fat pads
  • integument
  • subcutis
  • wrinkles

AR[править]

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer.


Keywords

  • PKB/Akt
  • Src
  • androgen receptor antagonist
  • antiandrogen
  • bipolar androgen therapy
  • cellular senescence
  • prostate cancer
  • supraphysiological androgen levels


Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells.


Keywords

  • Androgen receptor antagonists
  • Cellular senescence
  • Interleukin-23
  • Prostate cancer spheroids


A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging.


Keywords

  • adipocyte
  • adipose tissue
  • aging
  • lncRNA
  • long non-coding RNA
  • non-coding RNA
  • transcriptome


Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells.


Keywords

  • Akt inhibitor
  • Antiandrogen
  • Bcl-2 family inhibitor
  • Bipolar androgen therapy
  • Cellular senescence
  • HSP90 inhibitor
  • Prostate cancer
  • Senolytic compounds


Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice.


MeSH Terms

  • Adipocytes
  • Adipose Tissue
  • Animals
  • Anti-Bacterial Agents
  • Diet
  • Diet, High-Fat
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Lipid Metabolism
  • Longevity
  • Male
  • Metabolic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Obesity
  • Receptors, Androgen
  • Sex Characteristics

Keywords

  • androgen-insensitive syndrome
  • longevity
  • metabolic syndrome
  • testosterone
  • type 2 diabetes


A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake.


MeSH Terms

  • Aging
  • Animals
  • Cell Proliferation
  • Diet, High-Fat
  • Male
  • Mice
  • Myrtaceae
  • Plant Extracts
  • Prostate


Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Cohort Studies
  • CpG Islands
  • DNA Methylation
  • Forensic Genetics
  • Genetic Markers
  • Humans
  • Infant
  • Infant, Newborn
  • Linear Models
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Young Adult

Keywords

  • Age
  • CpG sites
  • DNA methylation
  • Forensic age estimation
  • Forensic epigenetics
  • Illumina MethylationEPIC

ARC[править]

The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract.


MeSH Terms

  • Aged
  • Aging
  • Alleles
  • Cataract
  • Female
  • Gene Expression Regulation
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Hydroxymethylglutaryl CoA Reductases
  • Intramolecular Transferases
  • Lens, Crystalline
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide

Keywords

  • ARC
  • HMGCR
  • LSS
  • SNPs
  • lanosterol


Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows.


Keywords

  • Müllerian inhibiting substance
  • female reproductive senescence
  • gonadotropin-releasing hormone neuron
  • preoptic area
  • ruminant


Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats.


MeSH Terms

  • Animals
  • Cataract
  • Dose-Response Relationship, Drug
  • Male
  • Naphthalenes
  • Rats
  • Rats, Sprague-Dawley
  • Resveratrol

Keywords

  • age-related cataracts
  • aging
  • oxidative stress
  • resveratrol

AREG[править]

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.


MeSH Terms

  • Amphiregulin
  • Animals
  • Antineoplastic Agents
  • B7-H1 Antigen
  • Cells, Cultured
  • Cellular Senescence
  • Drug Resistance, Neoplasm
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Stromal Cells
  • Tumor Microenvironment

Keywords

  • aging
  • amphiregulin
  • cancer resistance
  • clinical biomarker
  • combinational treatment
  • programmed cell death 1 ligand
  • senescence-associated secretory phenotype
  • stroma

ARNT[править]

Loss of ARNT in skeletal muscle limits muscle regeneration in aging.


Keywords

  • aging
  • hypoxia signaling
  • muscle regeneration


[Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Child
  • Child, Preschool
  • Dermis
  • Fetus
  • Fibroblasts
  • Humans
  • Infant
  • Infant, Newborn
  • Skin
  • Skin Aging
  • Young Adult

Keywords

  • ARNT
  • PCNA
  • aging
  • fibroblasts
  • skin


The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.


Keywords

  • E3 ubiquitin ligase
  • STIP1 homology and U-box-containing protein 1 (STUB1)
  • brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3)
  • cell cycle regulation
  • circadian clock
  • hydrogen peroxide
  • proteasome
  • protein degradation
  • senescence
  • ubiquitylation (ubiquitination)

ASB7[править]

ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.


Keywords

  • ASBs
  • maternal aging
  • meiosis
  • oocyte
  • reproduction

ASL[править]

Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE ASL MRI.


Keywords

  • aging
  • aquaporin-4
  • arterial spin labeling
  • blood-brain barrier
  • blood-brain interface
  • water permeability


Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI.


Keywords

  • MRI
  • aging
  • arterial spin labeling
  • cerebrovascular reactivity
  • phase-contrast


Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model.


Keywords

  • BOLD deactivation
  • aging
  • cerebral blood flow
  • domain-general
  • language fMRI
  • semantic fluency
  • sensitization

ASXL1[править]

ASXL1 mutation in clonal hematopoiesis.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Clonal Evolution
  • Codon, Nonsense
  • Hematologic Neoplasms
  • Hematopoiesis
  • Humans
  • Myeloproliferative Disorders
  • Neoplasm Proteins
  • Repressor Proteins

ATF4[править]

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles.


Keywords

  • aging
  • arteries
  • endoplasmic reticulum
  • vascular calcification
  • warfarin

ATF6[править]

Cellular proteostasis decline in human senescence.


Keywords

  • UPR
  • chaperones
  • heat shock response
  • protein homeostasis
  • senescence


Impact of endoplasmic reticulum stress on oocyte aging mechanisms.


Keywords

  • ER stress
  • GRP78
  • PERK
  • eIF2α
  • endoplasmic reticulum
  • mouse oocyte
  • oocyte aging
  • salubrinal


ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease.


Keywords

  • Ageing
  • Immunometabolism
  • Immunosenescence
  • Immunosuppression
  • Inflammaging
  • Neurodegeneration


Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.


Keywords

  • ER stress response
  • Golgi apparatus/complex stress response
  • SASP
  • immunosenescence
  • klotho
  • monocytes

ATG3[править]

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.


Keywords

  • Estrogen
  • MCF-7
  • MDA-MB-231
  • autophagy
  • mitochondria
  • senescence

ATG5[править]

Autophagy and heat-shock response impair stress granule assembly during cellular senescence.


Keywords

  • Ageing
  • Cellular senescence
  • Molecular biology
  • Oxidative stress
  • Stress granules

ATG7[править]

Age-related impairment of autophagy in cervical motor neurons.


Keywords

  • Aging
  • Autophagy
  • Motor neuron
  • Neuromuscular dysfunction
  • Spinal cord


Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts.


Keywords

  • autophagy
  • bioinformatics
  • functional network analysis
  • lung fibrosis
  • miR
  • proteomics
  • senescence


Regulation of autophagy by DNA G-quadruplexes.


Keywords

  • G-quadruplex
  • aging
  • astrocytes
  • autophagy
  • neurodegeneration
  • neurons


ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.


Keywords

  • ATG7
  • Aging
  • ameloblast
  • autophagy
  • epithelium
  • ferritin
  • hyperplasia
  • iron
  • secretion
  • tooth


Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts.


Keywords

  • aging
  • autophagy
  • calcium
  • cardiac physiology
  • ryanodine receptor

ATM[править]

SATMF Suppresses the Premature Senescence Phenotype of the ATM Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i].


Keywords

  • ATM
  • DNA damage
  • SATMF
  • fertility
  • leaf senescence


ATM mediated-p53 signaling pathway forms a novel axis for senescence control.


Keywords

  • ATM inhibition
  • Metabolic reprogrammer
  • Mitochondria
  • P53
  • Senescence alleviation


Non-canonical ATM/MRN activities temporally define the senescence secretory program.


Keywords

  • DNA damage response
  • MRN complex
  • NF-κB
  • chromatin
  • senescence secretome


ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.


Keywords

  • ATM
  • DNA damage response
  • NF-κB
  • aging
  • cellular senescence


ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis.


Keywords

Arabidopsis thaliana

  • ATM
  • DNA repair
  • double-strand breaks
  • histone methylation
  • leaf senescence


Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model.


MeSH Terms

  • Ataxia Telangiectasia Mutated Proteins
  • Axitinib
  • Cell Line, Tumor
  • Cellular Senescence
  • Coculture Techniques
  • Gene Expression Profiling
  • Glioblastoma
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Phosphorylation

Keywords

  • Axitinib
  • endothelial cells
  • glioblastoma
  • senescence


Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate.


Keywords

  • Aging
  • DNA fragmentation
  • Gene expression
  • Sperm


BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging.


MeSH Terms

  • Aging
  • Animals
  • Ataxia Telangiectasia
  • BRCA1 Protein
  • BRCA2 Protein
  • DNA Breaks, Double-Stranded
  • DNA Repair
  • Female
  • Fertility
  • Fertility Preservation
  • Humans
  • Mice
  • Oocytes
  • Ovarian Follicle
  • Ovarian Reserve
  • Ovary

Keywords 

         BRCA
       

         BRCA1/2
  • DNA repair
  • anti-Mullerian hormone
  • chemotherapy
  • mutations
  • oocyte
  • ovarian aging
  • ovarian reserve
  • ovarian response


ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy.


MeSH Terms

  • Anti-Retroviral Agents
  • Ataxia Telangiectasia Mutated Proteins
  • Cellular Senescence
  • DNA Damage
  • HIV Infections
  • Humans
  • T-Lymphocytes
  • Telomere

Keywords

  • ATM
  • DNA damage repair
  • HIV
  • T cell homeostasis
  • apoptosis
  • immune aging


SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.


MeSH Terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Carcinogenesis
  • Cells, Cultured
  • DNA Damage
  • Embryo, Mammalian
  • Fibroblasts
  • Gamma Rays
  • Hematologic Neoplasms
  • Heterozygote
  • Kaplan-Meier Estimate
  • Longevity
  • Lymphoma
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oxidative Stress
  • Protein-Serine-Threonine Kinases

Keywords

  • DNA damage
  • cancer
  • inflammation
  • lymphoma
  • oxidative stress


LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts.


MeSH Terms

  • Cell Proliferation
  • Cellular Senescence
  • Fibroblasts
  • Heterogeneous-Nuclear Ribonucleoprotein Group F-H
  • Humans
  • MicroRNAs
  • RNA, Long Noncoding
  • Skin
  • Skin Aging
  • Ultraviolet Rays

Keywords

  • cellular senescence
  • dermal fibroblast
  • lncRNA
  • microRNA
  • ultraviolet B


Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase.


MeSH Terms

  • Amino Acid Substitution
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Checkpoints
  • Cell Division
  • Cellular Senescence
  • DNA Damage
  • DNA Replication
  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Mutant Proteins
  • Protein-Serine-Threonine Kinases
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Telomerase
  • Telomere
  • Telomere Shortening

Keywords

  • Tel1
  • checkpoint
  • replicative senescence
  • telomere

ATP7A[править]

Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.


MeSH Terms

  • 3T3-L1 Cells
  • Adipocytes
  • Adipose Tissue, White
  • Aging
  • Animals
  • Body Weight
  • Copper
  • Copper-Transporting ATPases
  • Diet, High-Fat
  • Energy Metabolism
  • Insulin Resistance
  • Lipid Metabolism
  • Lipodystrophy
  • Lipolysis
  • Mice
  • Mice, Knockout

Keywords

  • ATP7A
  • Adipose tissues
  • Copper
  • Insulin resistance
  • Lipoatrophy

ATR[править]

Bloodstain age estimation through infrared spectroscopy and Chemometric models.


Keywords

  • Aging
  • Bloodstains
  • Chemometric
  • Forensic chemistry
  • MLR
  • PLSR


Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils.


Keywords

  • ANN
  • Artificial neural networks
  • FTIR
  • LDA
  • Linear discriminant analysis
  • Lubricant oil aging


Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.


Keywords

  • ATM
  • ATR
  • DNA damage response inhibitor
  • DNAPK
  • HNSCC
  • homologous recombination
  • ionizing radiation
  • kinase inhibitor
  • radiosensitivity
  • senescence


Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging.


Keywords

  • Activation energy
  • Aging
  • Bioethanol fuel
  • Kinetics analysis
  • Lifetime prediction
  • Materials chemistry
  • Materials science
  • Poly(vinylidene fluoride)


Supraphysiological protection from replication stress does not extend mammalian lifespan.


Keywords

  • DNA damage
  • aging
  • cancer
  • mouse models
  • replication stress


Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State.


Keywords

  • EEG
  • EEG slowing
  • brain aging
  • dominant frequency
  • prefrontal


Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane.


MeSH Terms

  • Humic Substances
  • Hydrogen Peroxide
  • Hydrophobic and Hydrophilic Interactions
  • Membranes, Artificial
  • Polymers
  • Sodium Hypochlorite
  • Sulfones
  • Ultrafiltration

Keywords

  • chemical cleaning
  • hydrogen peroxide (H2O2)
  • membrane aging
  • polyethersulfone (PES) ultrafiltration (UF) membrane
  • sodium hypochlorite (NaClO)


NF-κB signaling in skin aging.


MeSH Terms

  • Animals
  • Cellular Senescence
  • Humans
  • NF-kappa B
  • Phenotype
  • Signal Transduction
  • Skin Aging
  • Skin Neoplasms

Keywords

  • NF-κB
  • Senescence-associated secretory phenotype
  • Skin aging


Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation.


MeSH Terms

  • Administration, Cutaneous
  • Animals
  • Emulsions
  • Hydroxyproline
  • Ionic Liquids
  • Male
  • Rats, Wistar
  • Skin
  • Skin Absorption
  • Skin Aging
  • Thioctic Acid
  • Ultraviolet Rays

Keywords

  • Anti – aging efficacy
  • Ionic liquids
  • Skin retention
  • Solubility
  • Α – lipoic acid


Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber.


Keywords

  • aging resistance
  • graphene oxide
  • nitrile-butadiene rubber
  • nitrogen-doped

AVP[править]

Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Anxiety
  • Avoidance Learning
  • Cognition
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Object Attachment
  • Oxytocin
  • Sex Factors
  • Vasopressins
  • Young Adult

Keywords

  • Age
  • Attachment anxiety
  • Oxytocin
  • Processing speed
  • Sex
  • Vasopressin

B4GALT1[править]

Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans.


Keywords

  • Biomarker
  • Glycosylation
  • Lifespan regulation
  • bre-4
  • sqv-3

BACE1[править]

Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.


Keywords

  • aging
  • behavior
  • electrical stimulation
  • neurogenesis
  • rats
  • stroke


Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.


Keywords

  • Aging mice
  • Brain-derived neurotrophic factor precursor
  • Latent expression pattern
  • Lead
  • Pubertal exposure
  • Synaptic deficits
  • Tau phosphorylation

BAD[править]

I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway.


Keywords

  • Aging
  • Alzheimer’s disease
  • Behavior
  • I2 imidazoline receptors
  • NFAT
  • Neuroinflammation
  • Neuroprotection

BAK1[править]

Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon.


MeSH Terms

  • Animals
  • Apoptosis
  • Brain
  • Cell Line, Tumor
  • Cells, Cultured
  • Female
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Neural Stem Cells
  • Neurogenesis
  • Nonsense Mediated mRNA Decay
  • Polypyrimidine Tract-Binding Protein
  • RNA Splicing
  • bcl-2 Homologous Antagonist-Killer Protein

Keywords

  • AS-NMD
  • BAK
  • BCL2 family proteins
  • NMD
  • PTB
  • PTBP
  • PTBP2
  • UPF2
  • alternative splicing
  • cell death
  • neural development
  • neurogenesis
  • neuronal lifespan

BANF1[править]

An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood.


Keywords

  • BANF1
  • Néstor-Guillermo progeria syndrome
  • premature aging
  • progeria
  • whole exome sequencing

BATF[править]

LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.


Keywords

  • Bhlhe40
  • VSMC calcification/senescence
  • diabetes
  • lncRNA-ES3
  • microRNA
  • vascular aging

BAX[править]

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX interaction.


Keywords

  • ABT-263
  • BCL-XL
  • chemotherapy
  • radiation
  • senescence
  • senolytic


CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure.


Keywords

  • CREB signaling
  • aging
  • brain
  • hippocampus
  • ionizing radiation
  • label-free proteomics

BAZ2B[править]

Two conserved epigenetic regulators prevent healthy ageing.


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cognition
  • Cognitive Dysfunction
  • Epigenesis, Genetic
  • Healthy Aging
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Humans
  • Longevity
  • Lysine
  • Male
  • Memory
  • Methylation
  • Mice
  • Mitochondria
  • Neurons
  • Proteins
  • RNA Interference
  • Spatial Learning
  • Transcription Factors, General

BCL6[править]

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.


Keywords

  • Adaptive immunity
  • Aging
  • Cellular senescence
  • T cells
  • Vaccines

BCR[править]

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age.


Keywords

  • Aging
  • B-lymphocyte
  • BCR repertoire
  • CLL
  • Stereotypic BCR

BDNF[править]

Influence of [i]BDNF[/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases.


Keywords

  • Aging
  • BDNF gene
  • aging-related diseases
  • polymorphism


Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression.


Keywords

  • aging
  • antioxidant
  • brain functions
  • brain plasticity
  • cognition
  • psychomotor functions


Astroglia-Derived BDNF and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity.


Keywords

  • AMPA receptors
  • Arc/Arg3.1
  • GABA receptors
  • TrkB receptors
  • aging
  • calcium signalling
  • dendritic spines
  • diet
  • enriched environment
  • glia-neuron interactions
  • ion conductance microscopy
  • synaptic scaling
  • synaptic strength


BDNF reverses aging-related microglial activation.


Keywords

  • Aging
  • BDNF
  • CREB
  • Microglial activation
  • NF-кB
  • TrkB


High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio.


Keywords

  • Aging
  • exercise
  • functional capacity
  • muscle strength


Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging.


Keywords

  • Aging
  • Dorsal striatum
  • Metformin
  • Parkinson's disease
  • Reactive astrocyte


Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction.


Keywords

  • BDNF
  • adipocyte progenitors
  • adipose tissue
  • aging
  • sympathetic innervation


The Role of BDNF on Aging-Modulation Markers.


Keywords

  • BBB
  • astrocytes
  • brain aging
  • in vivo model
  • low dose BDNF


Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.


Keywords

  • aging
  • autophagy
  • mitochondrial dysfunction
  • polyamine


Microglia senescence occurs in both substantia nigra and ventral tegmental area.


Keywords

  • Parkinson's disease
  • aging-dependent neurodegeneration
  • dopamine neurons
  • microglia complexity
  • stereological analyses
  • tyrosine hydroxylase; microglia senescence


Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage.


MeSH Terms

  • Aging
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Exercise
  • Healthy Aging
  • Humans

Keywords

  • Ageing
  • BDNF
  • Brain
  • Physical activity


Impact of BDNF and sex on maintaining intact memory function in early midlife.


MeSH Terms

  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Memory, Short-Term
  • Menopause
  • Middle Aged
  • Neuroprotective Agents
  • Neuropsychological Tests
  • Reproduction
  • Sex Characteristics

Keywords

  • Aging
  • BDNF
  • Hormones
  • Memory
  • Menopause
  • Sex differences


Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats.


Keywords

  • Aging
  • BDNF
  • Object location memory
  • Radial arm maze
  • Spatial memory
  • Testosterone


The effects of aerobic exercise intensity on memory in older adults.


Keywords

  • BDNF
  • activité physique
  • aging
  • cognition
  • entraînement par intervalles de haute intensité
  • executive functions
  • exercice
  • exercise
  • fonctions exécutives
  • high-intensity interval training
  • memory
  • mémoire
  • physical activity
  • vieillissement


Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF).


Keywords

  • BDNF
  • Brain aging
  • neurophysiologic alterations
  • neuroprotection
  • vitamin D supplementation


Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum BDNF Levels in Healthy Older Adults: A Randomized Controlled Intervention Study.


MeSH Terms

  • Aged
  • Brain-Derived Neurotrophic Factor
  • Cognition
  • Correlation of Data
  • Exercise
  • Female
  • Healthy Aging
  • Healthy Lifestyle
  • Humans
  • Learning
  • Male
  • Mindfulness
  • Neuropsychological Tests
  • Outcome Assessment, Health Care

Keywords

  • Aging
  • brain-derived neurotrophic factor
  • cognitive training
  • mindfulness
  • physical exercise


Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway.


MeSH Terms

  • Aging
  • Animals
  • Antidepressive Agents
  • Autoimmunity
  • Biomarkers
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Depression
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Fatty Acid Elongases
  • Fatty Acids
  • Fish Oils
  • Inflammation
  • Linoleic Acids, Conjugated
  • Liver
  • Male
  • Mice, Inbred MRL lpr
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Stearoyl-CoA Desaturase
  • Tumor Necrosis Factor-alpha

Keywords

  • brain derived neurotrophic factor
  • brain fatty acid profile
  • conjugated linoleic acid
  • depression
  • fish oil
  • nuclear erythroid related factor-2

BGN[править]

Alterations of local functional connectivity in lifespan: A resting-state fMRI study.


Keywords

  • four-dimensional spatial-temporal consistency of local neural activity
  • lifespan
  • local functional connectivity
  • local functional connectivity density
  • resting-state fMRI

BHLHE40[править]

Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1.


MeSH Terms

  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p15
  • Homeodomain Proteins
  • Humans
  • Male
  • Prostatic Neoplasms
  • Thyroid Hormones

Keywords

  • BHLHE40
  • Cellular senescence
  • DEC1
  • Prostate cancer
  • Thyroid hormone

BLM[править]

[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis].


MeSH Terms

  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Humans
  • Imidazoles
  • Matrix Metalloproteinase 2
  • MicroRNAs
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Tetrazoles

Keywords

  • aging
  • invasion
  • microRNA
  • migration
  • olmesartan
  • vascular smooth muscle cells

BMI1[править]

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG.


Keywords

  • BH3 mimetics
  • BMI1
  • DIPG
  • H3K27M mutant
  • H3WT
  • PTC 028
  • RNAi screen
  • SASP
  • senescence

BMP2[править]

Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Interleukin-1beta
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular
  • Osteoblasts

Keywords

  • Interleukin-1β
  • Osteoblastic transition
  • Senescence
  • Vascular calcification

BMP4[править]

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome.


Keywords

  • aging
  • direct reprogramming
  • endothelial cell
  • human
  • hutchinson-gilford progeria syndrome
  • medicine
  • mouse
  • smooth muscle cell
  • vascular barrier

BMP7[править]

Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting BMP7.


MeSH Terms

  • Aging
  • Animals
  • Base Sequence
  • Bone Morphogenetic Protein 7
  • Down-Regulation
  • Glycerophosphates
  • MicroRNAs
  • Models, Biological
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Osteogenesis
  • Rats

Keywords

  • Aging
  • Mir-542-3p
  • Osteogenic differentiation
  • Vascular smooth muscle cells

BOC[править]

Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations.


MeSH Terms

  • Aged
  • Aging
  • Amino Acids
  • Body Weight
  • China
  • Dietary Proteins
  • Energy Intake
  • Energy Metabolism
  • Female
  • Humans
  • Male
  • Nutritional Requirements
  • Oxidation-Reduction
  • Phenylalanine
  • Recommended Dietary Allowances
  • Tyrosine

Keywords

  • indicator amino acid oxidation
  • older adults
  • phenylalanine oxidation
  • protein requirement
  • stable isotope

BPI[править]

High TARC plasma levels confer protection to long living individuals by inducing M2 profile.


Keywords

  • FACS
  • Longevity
  • M2 macrophages
  • Plasma profile
  • TARC


Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.


Keywords

  • FACS
  • M2 macrophages
  • immunity
  • longevity
  • patrolling-monocytes
  • plasma

BPIFB4[править]

New Insights for BPIFB4 in Cardiovascular Therapy.


Keywords

  • BPIFB4
  • aging
  • cardiovascular disease


LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Female
  • Frailty
  • Gene Expression Regulation
  • Genotype
  • Humans
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphoproteins
  • Specific Pathogen-Free Organisms

Keywords

  • BPIFB4
  • aging
  • frailty
  • longevity-associated variant-lav
  • survival

BRAF[править]

Conditional reprograming culture conditions facilitate growth of lower grade glioma models.


Keywords

  • BRAFV600E
  • Conditional reprogramming
  • NF1
  • Senescence
  • low grade glioma


Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib.


Keywords

  • Cobimetinib (PubChem CID: 16222096)
  • MEK
  • Nirogacestat (PubChem CID:46224413)
  • Notch
  • Senescence
  • Uveal melanoma


Mitochondrial metabolic reprograming via BRAF inhibition ameliorates senescence.


MeSH Terms

  • Cell Proliferation
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Drug Evaluation, Preclinical
  • Humans
  • Mitochondria
  • Proto-Oncogene Proteins B-raf

Keywords

  • BRAF
  • Metabolic reprogramming
  • Mitochondrial function
  • SB590885
  • Senescence

BRD2[править]

Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.


MeSH Terms

  • Animals
  • Female
  • Fertility
  • Grooming
  • Haploinsufficiency
  • Kidney
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Transcription Factors

BRD4[править]

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.


Keywords

  • BRD4
  • aurora kinase
  • cellular senescence
  • oesophageal cancer


BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake.


Keywords

  • BRD4
  • gene expression
  • inflammation
  • macrophage
  • senescence


BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes.


MeSH Terms

  • Animals
  • Cell Cycle Proteins
  • Cellular Senescence
  • Diabetes Mellitus, Type 1
  • Female
  • Humans
  • Insulin-Secreting Cells
  • Islets of Langerhans
  • Mice
  • Mice, Inbred NOD
  • Paracrine Communication
  • Protein Binding
  • Transcription Factors
  • Transcriptional Activation

Keywords

  • BET proteins
  • beta cells
  • senescence and SASP
  • type 1 diabetes

BTK[править]

Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.


Keywords

  • BTK
  • cellular senescence
  • healthspan
  • p53
  • progeria

C2[править]

[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats].


MeSH Terms

  • Aging
  • Animals
  • Male
  • Membrane Potential, Mitochondrial
  • Mitochondria, Muscle
  • Muscle, Skeletal
  • Physical Conditioning, Animal
  • Rats
  • Rats, Sprague-Dawley
  • Resistance Training

Keywords

  • fusion protein 2
  • mitochondria
  • quadriceps
  • rats
  • resistance training


Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain.


MeSH Terms

  • Animals
  • C2 Domains
  • Lycopersicon esculentum
  • Phosphatidylinositol 3-Kinase
  • Plants, Genetically Modified
  • Protein Binding
  • Tobacco

Keywords

  • C2 domain
  • Membrane binding
  • Phosphatidylinositol 3-kinase
  • Senescence

C3[править]

Inverse association between periumbilical fat and longevity mediated by complement C3 and cardiac structure.


Keywords

  • abdominal obesity
  • cardiac structure
  • complement C3
  • longevity
  • periumbilical fat


Complement C3 deficiency ameliorates aging related changes in the kidney.


MeSH Terms

  • Aging
  • Animals
  • Complement C3
  • Inflammation
  • Kidney
  • Kidney Diseases
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout

Keywords

  • Complement component 3
  • Kidney disorder
  • Senescence


Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Homeostasis
  • Immunity, Innate
  • Mice, Transgenic
  • Neurons
  • Racemases and Epimerases
  • Sialic Acid Binding Immunoglobulin-like Lectins
  • Sialic Acids
  • Synapses

Keywords

  • Aging
  • GNE
  • Glycocalyx
  • Microglia
  • Neurodegeneration
  • Neuroinflammation
  • Sialic acid


[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.]


MeSH Terms

  • Animals
  • Antioxidants
  • Female
  • Longevity
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Polyphenols
  • Survival Analysis

Keywords

  • BP-C3
  • Gompertz model
  • SkQ1
  • aging
  • herbal extracts
  • lifespan
  • metformin
  • polyphenols
  • resveratrol
  • tocopherol

C5[править]

The C5-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care.


Keywords

  • aging
  • case-finding
  • co-morbid conditions
  • comorbidité
  • dépistage
  • fragilité
  • frailty
  • primary care
  • recherche de cas
  • screening
  • soins de première ligne
  • vieillissement


Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma?


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cervical Vertebrae
  • Female
  • Geriatrics
  • Humans
  • Japan
  • Magnetic Resonance Imaging
  • Male
  • Paralysis
  • Severity of Illness Index
  • Spinal Canal
  • Spinal Cord
  • Spinal Cord Injuries
  • Tomography, X-Ray Computed
  • Wounds and Injuries

C6[править]

Evolution of the Aroma of Treixadura Wines during Bottle Aging.


Keywords

  • bottle aging
  • flavor profile
  • sensory evaluation
  • volatile composition
  • white wine


D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway.


Keywords

  • CDK6
  • D-galatose
  • YAP
  • cellular senescence
  • glioblastoma

C7[править]

The Vertebral Artery Convergence to the Cervical Spine in Elders.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cervical Vertebrae
  • Computed Tomography Angiography
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Vertebral Artery

Keywords

  • angiography
  • computed tomography
  • osteoarthritis
  • spine
  • vertebral artery
  • aging

C9[править]

C9orf72 in myeloid cells suppresses STING-induced inflammation.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • C9orf72 Protein
  • Dendritic Cells
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Humans
  • Inflammation
  • Interferon Type I
  • Membrane Proteins
  • Mice
  • Myeloid Cells
  • Neoplasms
  • T-Lymphocytes


Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain.


MeSH Terms

  • Aging
  • Alanine
  • Animals
  • Animals, Genetically Modified
  • Brain
  • C9orf72 Protein
  • DNA Repeat Expansion
  • Dipeptides
  • Drosophila
  • Female
  • Glycine

Keywords

  • Ageing
  • C9orf72
  • Dipeptide repeat proteins
  • Drosophila
  • PolyGA
  • Repeat size
  • Spread


Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity.


MeSH Terms

  • Amyotrophic Lateral Sclerosis
  • Animals
  • Astrocytes
  • Biomarkers
  • C9orf72 Protein
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Cerebral Cortex
  • Disease Models, Animal
  • Gene Expression Profiling
  • Glutamic Acid
  • Humans
  • Induced Pluripotent Stem Cells
  • Mice
  • Motor Neurons
  • Mutation
  • Oxidative Stress
  • Proteomics
  • Reactive Oxygen Species

Keywords

  • Amyotrophic lateral sclerosis
  • Astrocytes
  • Neurotoxicity
  • Oxidative stress
  • Senescence
  • iPSC

C9orf72[править]

Carriership of two copies of C9orf72 hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population.


Keywords

  • ALS
  • Aging
  • C9orf72
  • Case-control analysis
  • Intermediate repeats

CA1[править]

The relation between tau pathology and granulovacuolar degeneration of neurons.


Keywords

  • AT8
  • Aging
  • CA1
  • Casein kinase 1δ
  • Congo red
  • Dorsal raphe nucleus
  • Locus coeruleus
  • Neurodegeneration
  • Tau pathology


Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.


Keywords

  • Aging
  • Hippocampus
  • Locomotor activity
  • Memory and learning
  • Prefrontal cortex
  • Pyramidal neurons
  • dendritic spines


Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.


Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • C9ORF72
  • Dentate gyrus, adult neurogenesis
  • Frontotemporal dementia (FTD)
  • Klotho
  • Long-term depression (LTD)
  • Long-term potentiation (LTP)
  • Longevity


COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.


Keywords

  • BDNF
  • COX5A
  • ERK1/2
  • brain senescence
  • memory impairment
  • mitochondria


Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.


Keywords

  • Aging
  • Fto
  • Hippocampus
  • Mice
  • Obesity


Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.


Keywords

  • aging
  • dendrites
  • hippocampus
  • memory and learning
  • nucleus accumbens
  • prefrontal cortex
  • sodium phenylbutyrate


Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.


Keywords

  • Alzheimer’s disease
  • aging
  • brain ischemia
  • glia
  • neuroinflammation


Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.


MeSH Terms

  • Animals
  • Cognitive Aging
  • Dentate Gyrus
  • Hippocampus
  • Maze Learning
  • Rats
  • Rats, Inbred F344
  • Spatial Memory
  • Transcriptome

Keywords

  • aging
  • hippocampus
  • pattern separation
  • reference memory
  • spatial discrimination
  • transcription


Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Brain Mapping
  • Female
  • Hippocampus
  • Humans
  • Longevity
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Young Adult


Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.


Keywords

  • aging
  • laminarin
  • neuroinflammation
  • neuroprotection
  • oxidative stress
  • transient cerebral ischemia


Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.


Keywords

  • Aging
  • CB1 receptor
  • Hippocampus
  • Mitochondria
  • Mitophagy


Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via CA1-Frontal Circuit.


Keywords

  • aging
  • functional connectivity
  • hippocampus
  • spatial memory


Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.


Keywords

  • Acetylcholine
  • Aging
  • Brain
  • Immunohistochemistry
  • m1AChR
  • qRT-PCR


Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • CA1 Region, Hippocampal
  • Catalase
  • Dopamine
  • Eclipta
  • Galactose
  • Gene Expression Regulation, Enzymologic
  • Glutathione Peroxidase
  • Glutathione Reductase
  • Male
  • Memory Disorders
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Norepinephrine
  • Plant Extracts
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin
  • Spatial Learning
  • Superoxide Dismutase

Keywords

  • Antioxidants
  • Eclipta
  • Galactose
  • Memory disorders
  • Spatial learning


Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.


MeSH Terms

  • Aged
  • Aging
  • Alzheimer Disease
  • Atrophy
  • Cohort Studies
  • Cross-Sectional Studies
  • Dentate Gyrus
  • Female
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Risk

Keywords

  • Aging
  • Alzheimer's disease
  • Hippocampal subfields
  • MRI


Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors.


MeSH Terms

  • Animals
  • Behavior, Animal
  • Cognitive Dysfunction
  • Dendritic Spines
  • Hematopoietic Stem Cell Transplantation
  • Hippocampus
  • Humans
  • Long-Term Potentiation
  • Maze Learning
  • Memory
  • Mice
  • Neurons
  • Radiotherapy
  • Recovery of Function
  • Spinocerebellar Ataxias
  • Treatment Outcome

Keywords

  • Aging
  • Bone marrow stem cells
  • Learning and memory
  • Microglia
  • Radiotherapy


Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.


MeSH Terms

  • Aging
  • Animals
  • Cyclin D1
  • Cyclin-Dependent Kinase 4
  • Female
  • Hippocampus
  • Learning
  • Memory
  • Memory Consolidation
  • Mice
  • Mice, Inbred C57BL
  • Neural Stem Cells
  • Neurogenesis


Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.


Keywords

  • aging
  • hippocampus
  • memory
  • mild cognitive impairment
  • neuroimaging
  • subfields


Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.


MeSH Terms

  • Aging
  • Animals
  • CA3 Region, Hippocampal
  • Long-Term Potentiation
  • Mice
  • Mossy Fibers, Hippocampal
  • Spermidine
  • Synaptic Transmission
  • Synaptic Vesicles


Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.


MeSH Terms

  • Aging
  • Animals
  • Caspase 6
  • Caspase Inhibitors
  • Cognitive Dysfunction
  • Female
  • Humans
  • Inflammation
  • Male
  • Methylene Blue
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic

Keywords

  • Alzheimer disease
  • Axonal degeneration
  • Caspase-6
  • Caspase-6 inhibitor
  • Hippocampal CA1
  • Hippocampal fibres
  • Methylene blue
  • Synaptic plasticity
  • White matter


Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.


Keywords

  • CA1 area
  • CaMKII
  • IntelliCages
  • aging
  • dendritic spines
  • memory
  • postsynaptic density


PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.


Keywords

  • CA1
  • CA3
  • Fluoro-Jade C
  • aging
  • microglia
  • radial arm maze


Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.


MeSH Terms

  • Aging
  • Animals
  • Male
  • Mice
  • Neuronal Plasticity
  • Oxidative Stress
  • Random Allocation
  • Receptors, N-Methyl-D-Aspartate
  • Testosterone

Keywords

  • Alzheimer’s disease
  • N-methyl-D-aspartate receptor-1
  • Senescence accelerated mouse
  • Testosterone
  • oxidative stress


Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.


MeSH Terms

  • Aging
  • Animals
  • Cholinergic Neurons
  • Hippocampus
  • Mice
  • Mice, Inbred C57BL
  • Physical Conditioning, Animal
  • Presynaptic Terminals
  • Spatial Memory
  • Synaptophysin

Keywords

  • Aging
  • Cholinergic cells
  • Hippocampus
  • Memory
  • Physical training
  • Presynaptic terminals
  • Synaptophysin


Senescent neurophysiology: Ca signaling from the membrane to the nucleus.


MeSH Terms

  • Aging
  • Animals
  • CA1 Region, Hippocampal
  • Calcium Signaling
  • Cell Nucleus
  • Epigenesis, Genetic
  • Excitatory Postsynaptic Potentials
  • Humans
  • Membrane Potentials
  • Neuronal Plasticity
  • Pyramidal Cells
  • Receptors, N-Methyl-D-Aspartate

Keywords

  • Afterhyperpolarization
  • Aging
  • Epigenetics
  • Hippocampus
  • N-methyl-D-aspartate receptor
  • Synaptic plasticity
  • Transcription

CA2[править]

Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice.


Keywords

  • Aging
  • Behavior analysis
  • Hippocampus
  • Shaking exercise
  • Spatial cognition


One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Atrophy
  • Case-Control Studies
  • Cognitive Dysfunction
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Neuroimaging

Keywords

  • Alzheimer's disease
  • biomarker
  • hippocampal
  • mild cognitive impairment
  • neurodegenerative diseases
  • normal aging
  • radial distance
  • subfield atrophy


Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory.


MeSH Terms

  • Aging
  • Animals
  • Animals, Newborn
  • CA2 Region, Hippocampal
  • Interneurons
  • Long-Term Synaptic Depression
  • Male
  • Memory
  • Mice
  • Mice, Inbred C57BL
  • Neural Inhibition
  • Neuregulin-1
  • Neuronal Plasticity
  • Parvalbumins
  • Receptor, ErbB-4
  • Receptors, Opioid, delta
  • Signal Transduction
  • Social Behavior
  • Synapses
  • gamma-Aminobutyric Acid

Keywords

  • ErbB4
  • adolescence
  • area CA2
  • delta opioid receptors
  • hippocampus
  • long-term depression
  • neuregulin 1
  • parvalbumin interneuron
  • perineuronal net
  • social memory

CA3[править]

Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • OXYS rats
  • aging
  • hippocampal mossy fibers
  • hippocampus
  • neurogenesis
  • postnatal development


Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis.


Keywords

  • aging
  • conditional transgenic
  • giant synapse
  • stratum lucidum
  • synaptogenesis


Metabotropic Glutamate Receptors at the Aged Mossy Fiber - CA3 Synapse of the Hippocampus.


Keywords

  • aging
  • hippocampal area CA3
  • mGluRs
  • mossy fibers
  • synaptic transmission

CACNA1S[править]

Increased calcium channel in the lamina propria of aging rat.


MeSH Terms

  • Aging
  • Animals
  • Calcium Channel Blockers
  • Calcium Channels
  • Cell Line
  • Fibroblasts
  • Gene Expression Regulation
  • Humans
  • Larynx
  • Male
  • Mucous Membrane
  • Rats
  • Rats, Sprague-Dawley
  • Verapamil

Keywords

  • aging
  • calcium channel
  • extracellular matrix
  • vocal fold

CAD[править]

Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease.


Keywords

  • Aging
  • Coronary artery calcification
  • Intravascular ultrasound
  • Klotho


Shear bond strengths of aged and non-aged CAD/CAM materials after different surface treatments.


Keywords

  • Bond strength
  • Computer-aided design and computer-aided manufacturing (CAD/CAM)
  • Laser
  • Repair
  • Surface treatment
  • Thermal aging


Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report.


MeSH Terms

  • Aged
  • Aortic Valve Stenosis
  • Cardiovascular Diseases
  • Comorbidity
  • Echocardiography
  • Female
  • Fracture Fixation
  • Hip Fractures
  • Hospital Mortality
  • Humans
  • Male
  • Postoperative Complications
  • Prognosis
  • Risk Factors

Keywords

  • aging
  • echocardiographic abnormality
  • hip fracture surgery
  • mortality
  • postoperative cardiac complications


[Polymorbidity in elderly patients needing myocardial revascularization (a review article).]


MeSH Terms

  • Aged
  • Cognitive Dysfunction
  • Coronary Artery Disease
  • Humans
  • Myocardial Revascularization
  • Quality of Life
  • Risk

Keywords

  • aging
  • elderly
  • ischemic heart disease
  • myocardial revascularization
  • polymorbidity


Fracture force of CAD/CAM resin composite crowns after in vitro aging.


MeSH Terms

  • Ceramics
  • Composite Resins
  • Computer-Aided Design
  • Crowns
  • Dental Porcelain
  • Dental Restoration Failure
  • Dental Stress Analysis
  • Humans
  • Materials Testing

Keywords

  • Aging
  • CAD/CAM
  • CAD/CAM bloc
  • Dental material
  • Fit
  • Preparation
  • Resin composite
  • Resin-based material
  • Storage
  • TCML


Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns.


MeSH Terms

  • Ceramics
  • Computer-Aided Design
  • Crowns
  • Dental Porcelain
  • Dental Prosthesis Design
  • Humans
  • Materials Testing

Keywords

  • CAD-CAM
  • chairside
  • dental crowns
  • lithium disilicate
  • longevity
  • survival


Acute resveratrol supplementation in coronary artery disease: towards patient stratification.


MeSH Terms

  • Aged
  • Biomarkers
  • Brachial Artery
  • Cardiac Rehabilitation
  • Coronary Artery Bypass
  • Coronary Artery Disease
  • Cross-Over Studies
  • Exercise Therapy
  • Female
  • Humans
  • Kinetics
  • Male
  • Middle Aged
  • Oxygen
  • Oxygen Consumption
  • Percutaneous Coronary Intervention
  • Resveratrol
  • Single-Blind Method
  • Treatment Outcome
  • Vasodilation

Keywords

  • Antioxidant
  • aging
  • endothelial dysfunction
  • oxygen uptake

CARM1[править]

CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis.


MeSH Terms

  • Aged
  • Animals
  • Apoptosis
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Epithelial Cells
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Naphthalenes
  • Protein-Arginine N-Methyltransferases
  • Pulmonary Disease, Chronic Obstructive
  • Respiratory Mucosa
  • Wound Healing

Keywords

  • CARM1
  • COPD
  • airway epithelium
  • senescence

CASP3[править]

Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation.


MeSH Terms

  • Aging
  • Animals
  • Bone Development
  • Cartilage
  • Chondrocytes
  • Diclofenac
  • Disease Models, Animal
  • Estrogen Receptor alpha
  • Flavonoids
  • Gallic Acid
  • Gene Expression Regulation
  • Humans
  • Iodoacetates
  • Matrix Metalloproteinase 13
  • Metabolism
  • Osteoarthritis
  • Ovariectomy
  • Plant Extracts
  • Primulaceae
  • Rats

CAT[править]

Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease.


Keywords

  • Chronic-obstructive pulmonary disease - Inhaler devices
  • Compliance
  • Geriatrics


7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster.


Keywords

  • 4-PSQ
  • 7-chloro-4-(phenylselanyl) quinolone
  • Antioxidant effect
  • Diabetic-like phenotype
  • Hyperglycidic diet
  • Longevity
  • Oxidative stress


Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis.


Keywords

  • Aging
  • Blood-brain barrier
  • Brain
  • Oxidative stress
  • Sepsis


2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat.


Keywords

  • 2-Deoxy- d-glucose
  • Aging
  • Brain
  • CRM
  • Mitohormosis
  • ROS


Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice.


Keywords

  • Aging
  • Ceftriaxone
  • D-galactose
  • Mice
  • Oxidative stress


Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor.


MeSH Terms

  • Animals
  • Antioxidants
  • Cellular Senescence
  • Disease Models, Animal
  • Fatty Liver
  • Forkhead Box Protein O1
  • Galactose
  • Ginsenosides
  • Lipid Peroxidation
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Protective Agents
  • Transcription Factors

Keywords

  • D-galactose
  • FOXO1
  • Non-alcoholic fatty liver disease
  • Rg1
  • Senescence


Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Caloric Restriction
  • Catalase
  • Erythrocytes
  • Female
  • Glutathione
  • Lipid Peroxidation
  • Malondialdehyde
  • Mammary Neoplasms, Experimental
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Superoxide Dismutase

Keywords

  • MMTV-TGF-α mice
  • breast cancer
  • energy restriction
  • intermittent calorie restriction
  • mammary tumor
  • oxidative stress


The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata.


MeSH Terms

  • Aquatic Organisms
  • Chlorophyta
  • Fresh Water
  • Hydrodynamics
  • Lipid Peroxidation
  • Metal Nanoparticles
  • Particle Size
  • Reactive Oxygen Species
  • Silver
  • Static Electricity
  • Toxicity Tests

Keywords

  • Aquatic toxicology
  • Ecotoxicology
  • Environmental fate
  • Heavy metals
  • Nanoparticle aging
  • Nanotoxicology

CBS[править]

Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.


Keywords

  • Cellular senescence
  • Cystathionine β-synthase
  • Human adipose-derived mesenchymal stem cells
  • Inflammation
  • Oxidative stress and adipogenesis


Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.


MeSH Terms

  • Animals
  • Antioxidants
  • Cardiovascular System
  • Cystathionine beta-Synthase
  • Cystathionine gamma-Lyase
  • Gene Expression Regulation, Enzymologic
  • Hydrogen Sulfide
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Reperfusion Injury
  • Myocytes, Cardiac
  • Nitric Oxide
  • Phenotype
  • Reactive Oxygen Species
  • Sulfurtransferases
  • Vasodilation

Keywords

  • 3-mercaptopyruvate transferase (3-MST)
  • Aging
  • Blood pressure
  • Myocardial infarction
  • Nitric Oxide (NO)
  • Reactive Oxygen Species (ROS)

CBX3[править]

Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development.


Keywords

  • Aging
  • Bone
  • CBX1
  • CBX2
  • CBX3
  • CBX4
  • CBX5
  • CBX6
  • CBX7
  • CBX8
  • Cancer
  • Chromatin
  • Development
  • Epigenetics
  • H3K27me3
  • H3K9me3
  • Lineage-commitment
  • Osteoblast
  • Senescence
  • Stem cell

CCK[править]

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.


Keywords

  • Intervertebral disc degeneration
  • NF-κB pathway
  • Nrf2
  • Quercetin
  • Senescence


Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.


Keywords

  • Astragalus
  • BMSCs
  • VD-FGF23-Klotho axis
  • aging
  • osteogenesis differentiation


Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial.


Keywords

  • aging
  • appetite
  • energy intake
  • gastric emptying
  • glucose
  • gut hormones
  • whey protein


Lactose induced redox-dependent senescence and activated Nrf2 pathway.


Keywords

  • Lactose
  • Nrf2
  • ROS
  • cellular senescence
  • oxidative stress


Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.


MeSH Terms

  • Adenine
  • Animals
  • Atherosclerosis
  • Autophagy
  • Cell Survival
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Disease Progression
  • Foam Cells
  • Hepatocyte Growth Factor
  • Lipid Metabolism
  • Lipoproteins, LDL
  • Mice
  • Proto-Oncogene Proteins
  • Quercetin
  • RAW 264.7 Cells
  • Sirolimus
  • Up-Regulation

Keywords

  • RAW264.7
  • atherosclerosis
  • autophagy
  • quercetin
  • senescence


LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss.


MeSH Terms

  • Adenosine Triphosphate
  • Aging
  • Animals
  • Cell Survival
  • DNA-Binding Proteins
  • Gene Silencing
  • Hair Cells, Auditory
  • Hearing Loss
  • Mice
  • Mitochondria
  • Organelle Biogenesis
  • RNA, Long Noncoding
  • Resveratrol
  • Signal Transduction
  • Transcription Factors


Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins.


Keywords

  • Aging
  • Catecholaminergic neurons
  • Feeding response
  • Glucoprivation
  • Rostral ventrolateral medulla


Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.


MeSH Terms

  • Aging
  • Amino Acid Sequence
  • Animals
  • Antihypertensive Agents
  • Blood Pressure
  • Cholecystokinin
  • Dipeptides
  • Drug Evaluation, Preclinical
  • Hypertension
  • Male
  • Mesenteric Arteries
  • Nitric Oxide
  • Peptide Library
  • Proglumide
  • Rats
  • Rats, Inbred SHR
  • Receptors, Cholecystokinin
  • Vasodilation
  • Vasodilator Agents

Keywords

  • aging
  • dipeptide library
  • nitric oxide
  • structure-activity relationship
  • vasorelaxation


Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells.


MeSH Terms

  • Animals
  • Autoantigens
  • Carrier Proteins
  • Cellular Senescence
  • Flavonoids
  • Foam Cells
  • Lipid Metabolism
  • Lipoproteins, LDL
  • Mice
  • Proteasome Endopeptidase Complex
  • RAW 264.7 Cells
  • Signal Transduction

Keywords

  • CKIP-1/REGγ signaling
  • Fisetin
  • Lipid accumulation
  • RAW264.7
  • Senescence

CCL11[править]

CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders.


Keywords

  • Alzheimer’s disease
  • CCL-11
  • aging
  • behaviour
  • biomarkers
  • brain
  • cytokines
  • eotaxin
  • prevention
  • schizophrenia
  • stroke

CCL17[править]

Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice.


Keywords

  • aging
  • heart
  • kidney
  • metabolism
  • obesity

CCL19[править]

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Animals
  • Astrocytes
  • Blood-Brain Barrier
  • Cell Line, Tumor
  • Central Nervous System Neoplasms
  • Chemokine CCL19
  • Chemokine CXCL12
  • Disease Models, Animal
  • Female
  • Gliosis
  • Humans
  • Intravital Microscopy
  • Lymphoma
  • Male
  • Mice
  • Mice, Transgenic
  • Microscopy, Fluorescence, Multiphoton
  • Middle Aged
  • NF-kappa B
  • Receptors, CCR7
  • Time-Lapse Imaging
  • Young Adult

Keywords

  • CCL19
  • CNSL
  • CXCL12
  • DLBCL
  • PCNSL
  • SCNSL
  • gliosis
  • lymphoma
  • metastasis
  • neuroinflammation

CCL2[править]

β1 Integrin regulates adult lung alveolar epithelial cell inflammation.


MeSH Terms

  • Aging
  • Alveolar Epithelial Cells
  • Animals
  • Cell Adhesion
  • Chemokine CCL2
  • Chemokines
  • Disease Models, Animal
  • Epithelium
  • Integrin beta1
  • Lung
  • Macrophages
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Pneumonia
  • Pulmonary Disease, Chronic Obstructive
  • Receptors, CCR2

Keywords

  • COPD
  • Inflammation
  • Integrins
  • Macrophages
  • Pulmonology

CCL20[править]

p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.


Keywords

  • Aging
  • Antiretroviral drugs
  • HIV
  • Inflammation
  • NNRTI
  • Senescence
  • p53

CCL28[править]

Age-related chemokine alterations affect IgA secretion and gut immunity in female mice.


Keywords

  • Aging
  • CCL25
  • CCL28
  • Gut immunity
  • IgA

CCN1[править]

Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.


Keywords

  • Deep endometriosis
  • Fibrogenesis
  • Mouse
  • Senescence
  • Sodium tanshinone IIA sulfonate


Inhibition of cellular communication network factor 1 (CCN1)-driven senescence slows down cartilage inflammaging and osteoarthritis.


Keywords

  • CCN1
  • Cartilage inflammaging
  • Chondrocyte cluster
  • Osteoarthritis
  • Senescence


The senescence-associated matricellular protein CCN1 in plasma of human subjects with idiopathic pulmonary fibrosis.


MeSH Terms

  • Aged
  • Cellular Senescence
  • Cysteine-Rich Protein 61
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Predictive Value of Tests
  • Survival Rate

Keywords

  • CCN1
  • Cellular senescence
  • Idiopathic pulmonary fibrosis
  • Transplant-free survival

CCN3[править]

CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta.


Keywords

  • CCN3
  • abnormally invasive placenta
  • invasion
  • preeclampsia
  • senescence
  • trophoblast


CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage.


Keywords

  • CCN3
  • NOV
  • SASP
  • aging
  • cellular communication network factor 3
  • oxidative stress
  • p21
  • p53
  • primary chondrocytes
  • senescence

CCND1[править]

Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells.


MeSH Terms

  • Cells, Cultured
  • Cellular Senescence
  • Dental Pulp
  • Doxorubicin
  • Humans
  • Hydrogen Peroxide
  • Stem Cells
  • Ultraviolet Rays

Keywords

  • Cell cycle
  • ROS
  • Stress induced senescence
  • Ultraviolet irradiation
  • p21

CCND3[править]

The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.


Keywords

  • Aging
  • Immunosuppression
  • Osteogenic differentiation
  • Periodontal ligament stem cells
  • Peripheral blood mononuclear cells
  • Tissue engineering

CCR2[править]

Hip Fracture Leads to Transitory Immune Imprint in Older Patients.


Keywords

  • acute stress
  • aging
  • immune response
  • inflammation
  • regulation loop


The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice.


Keywords

  • Aging
  • CCR2
  • Fertility
  • Follicle
  • Ovary


Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.


Keywords

  • inflammatory macrophage
  • kidney function
  • non-resolving inflammation
  • obesogenic aging


Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction.


Keywords

  • Aging
  • Bone marrow transplantation
  • Cardiology
  • Hematopoietic stem cells
  • Macrophages


Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Chemokine CCL2
  • Disease Models, Animal
  • Female
  • Gene Expression Profiling
  • Inflammation
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Non-alcoholic Fatty Liver Disease
  • Organ Size
  • Receptors, CCR2


Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments.


MeSH Terms

  • Aged
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Cellular Microenvironment
  • Cellular Senescence
  • Chemokine CCL2
  • Colorectal Neoplasms
  • Disease Progression
  • Down-Regulation
  • Doxorubicin
  • Female
  • Glucuronidase
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B
  • Neoplasm Invasiveness
  • Proportional Hazards Models
  • Signal Transduction
  • Stromal Cells

Keywords

  • CCL2
  • Klotho
  • colorectal cancer
  • senescence

CCR3[править]

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro.


MeSH Terms

  • Aging
  • Animals
  • Extracellular Matrix
  • Female
  • Germ Cells
  • Granulosa Cells
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Inflammation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Molecular Weight
  • Ovary
  • Stromal Cells

Keywords

  • hyaluronan fragments
  • inflammation
  • ovarian biology
  • reproductive aging
  • stroma

CCR5[править]

[Enhancement can do harm].


MeSH Terms

  • Adult
  • Aged
  • CRISPR-Cas Systems
  • China
  • Embryo Research
  • Gene Editing
  • Gene Silencing
  • Genetic Enhancement
  • Genome-Wide Association Study
  • HIV Infections
  • HIV-1
  • Humans
  • Longevity
  • Middle Aged
  • Receptors, CCR5

CCS[править]

Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study.


Keywords

  • Aging
  • Canada
  • Confidence Intervals
  • Death
  • Frail Elderly
  • Frailty
  • Heart
  • Multivariate Analysis
  • Prognosis
  • Risk Factors


Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study.


Keywords

  • Atrophy
  • cognition
  • imaging markers
  • medial temporal lobe
  • microbleeds
  • normal aging


Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Amyloid beta-Peptides
  • Apolipoprotein E4
  • Brain
  • Cognitive Aging
  • Female
  • Hippocampus
  • Humans
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Positron-Emission Tomography

Keywords

  • APOE
  • Aging
  • Amyloid
  • Hippocampus


Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging.


Keywords

  • APOE genotyping
  • amyloid deposition
  • magnetic resonance imaging
  • normal aging
  • positron emission tomography


Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly.


Keywords

  • Aging
  • Endothelial dysfunction
  • Osteoporosis
  • Subclinical atherosclerosis

CD14[править]

Human innate immune cell crosstalk induces melanoma cell senescence.


Keywords

  • NK cell
  • cytokines
  • melanoma
  • senescence
  • slanMo


Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP.


Keywords

  • CTX
  • DC-STAMP
  • DNA methylation
  • aging
  • cell fusion
  • epigenetics
  • menopause
  • multinucleation
  • osteoclast
  • osteoclastogenesis


Association of CD14 with incident dementia and markers of brain aging and injury.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Atrophy
  • Biomarkers
  • Brain
  • Cognitive Dysfunction
  • Dementia
  • Female
  • Humans
  • Incidence
  • Lipopolysaccharide Receptors
  • Longitudinal Studies
  • Male
  • Middle Aged


Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Biomarkers
  • Bone Regeneration
  • Bone and Bones
  • Female
  • Fractures, Bone
  • Gene Expression
  • Lipopolysaccharide Receptors
  • Macrophages
  • Osteotomy
  • Rats, Sprague-Dawley
  • Wound Healing

Keywords

  • CD14+ cells
  • aging
  • angiogenesis
  • bone regeneration
  • compromised healing
  • macrophage
  • monocyte

CD19[править]

Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice.


MeSH Terms

  • Animals
  • Antigens, CD19
  • Cell Line, Tumor
  • Combined Modality Therapy
  • Disease-Free Survival
  • HEK293 Cells
  • Healthy Volunteers
  • Humans
  • Immunologic Memory
  • Immunotherapy, Adoptive
  • Longevity
  • Lymphoma, B-Cell
  • Mice
  • Neoplasm Recurrence, Local
  • Receptors, Chimeric Antigen
  • Recombinant Proteins
  • Remission Induction
  • T-Lymphocytes
  • Time Factors
  • Transduction, Genetic
  • Transplantation, Autologous
  • Xenograft Model Antitumor Assays

Keywords

  • Autologous CD19 T cells
  • Chimeric antigen receptor
  • Memory T cells
  • Sequential therapy

CD27[править]

The Interplay between CD27 and CD27 B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.


Keywords

  • CD27
  • VH repertoire
  • aging
  • germinal center
  • immunodeficiency
  • immunological memory
  • memory B cells
  • pregnancy
  • spleen
  • vaccine


CMV-independent increase in CD27-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians.


Keywords

  • Biomarkers
  • Senescence


Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis.


MeSH Terms

  • CD56 Antigen
  • CD57 Antigens
  • Case-Control Studies
  • Cellular Senescence
  • Cytotoxicity, Immunologic
  • Female
  • Gene Expression Regulation
  • Host-Parasite Interactions
  • Humans
  • Interferon-gamma
  • Killer Cells, Natural
  • Lectins, C-Type
  • Leishmania braziliensis
  • Leishmaniasis, Cutaneous
  • Male
  • Oligosaccharides
  • Receptors, Immunologic
  • Severity of Illness Index
  • Sialyl Lewis X Antigen
  • Signal Transduction
  • Skin
  • T-Lymphocytes, Cytotoxic

Keywords

Leishmania braziliensis

  • CD8+ T cells
  • cellular senescence
  • cutaneous leishmaniasis
  • immunopathology
  • natural killer cells


CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.


Keywords

  • Aging
  • B cell
  • Frailty
  • Immunosenescence

CD28[править]

Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome.


Keywords

  • CD28null T cells
  • CD4+ T cells
  • acute coronary syndrome
  • immunosenescence
  • infection


The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus.


Keywords

  • angiogenic T cells
  • cardiovascular risk
  • endothelial progenitor cells
  • immunosenescence
  • systemic lupus erythematosus


Emergence of T cell immunosenescence in diabetic chronic kidney disease.


Keywords

  • BMI
  • CKD
  • Diabetes
  • Immunosenescence
  • T cell


The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals.


Keywords

  • CD4/CD8 ratio
  • Chlamydia pneumoniae
  • Immune profile
  • Immunosenescence
  • Lymphocyte subsets


Next steps in mechanisms of inflammaging.


Keywords

  • Aging
  • autophagy
  • glutathione
  • membrane potential
  • mitochondria
  • oxidative stress


A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV.


MeSH Terms

  • Adult
  • Anti-HIV Agents
  • Anticholesteremic Agents
  • Atorvastatin
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Female
  • HIV Infections
  • HIV Protease Inhibitors
  • Humans
  • Immunosenescence
  • Inflammation
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Pilot Projects
  • Raltegravir Potassium


Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.


Keywords

  • Periodontal ligament stem cells
  • T lymphocytes
  • age
  • coculture
  • cytokines
  • immunophenotyping
  • immunosenescence
  • immunosuppression
  • peripheral blood mononuclear cells


Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice.


Keywords

  • Liuwei Dihuang decoction
  • aging
  • cognition
  • immune response
  • inflammation


Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors.


Keywords

  • CD28− T cells
  • HaploSCT
  • immune monitoring
  • immunosenescence
  • telomere length


Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection.


Keywords

  • Biological aging
  • Cytomegalovirus
  • Depression
  • Immunosenescence
  • Major depressive disorder
  • Sex differences
  • T-cells


Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression.


Keywords

  • Ageing
  • Cell senescence
  • Cognitive impairment
  • Immune ageing
  • Rheumatoid arthritis


Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients.


Keywords

  • immunosenescence
  • lupus-associated brain fog
  • systemic lupus erythematosus


T cells, aging and senescence.


Keywords

  • Aging
  • Senescence
  • T cells


Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study.


MeSH Terms

  • Adult
  • Alcoholism
  • CD28 Antigens
  • CD4-Positive T-Lymphocytes
  • CD57 Antigens
  • CD8-Positive T-Lymphocytes
  • Cross-Sectional Studies
  • Female
  • HIV Infections
  • Hepatitis C
  • Humans
  • Immunologic Memory
  • Immunosenescence
  • Leukocyte Common Antigens
  • Linear Models
  • Liver Cirrhosis, Alcoholic
  • Male
  • Phenotype
  • Randomized Controlled Trials as Topic
  • Russia
  • Zinc

Keywords

  • Alcohol
  • HIV
  • Immune senescence
  • Liver fibrosis
  • Russia


Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.


Keywords

  • aging
  • cellular senescence
  • memory T cells
  • stem cell


Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow.


Keywords

  • Aging
  • Antibodies
  • B cells
  • Bone marrow
  • Exhaustion
  • Immunosenescence
  • Inflammation
  • Pro-inflammatory
  • Senescence

CD33[править]

Maximum reproductive lifespan correlates with CD33rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging.


MeSH Terms

  • Animals
  • Gene Dosage
  • Humans
  • Longevity
  • NADPH Oxidases
  • Neutrophils
  • Reactive Oxygen Species
  • Sialic Acid Binding Ig-like Lectin 3
  • Whale, Killer

Keywords

CD33rSIGLEC

  • NADPH-oxidase
  • prolonged post-reproductive lifespan
  • reactive oxygen species

CD34[править]

Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.


Keywords

  • SUSD2
  • adipose tissue
  • apoptosis
  • bone marrow
  • clonogenicity
  • endometrium
  • menstrual fluid
  • perivascular mesenchymal stromal cells
  • placenta
  • senescence


ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging.


Keywords

  • ACE2
  • Aging
  • Angiotensin-(1-7)
  • Hematopoietic stem/progenitor cells
  • Ischemia


Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood CD34 Cells in Adults.


Keywords

  • CD34+ cells
  • aging
  • day easy exercise
  • mind–body intervention


Human Thymic Involution and Aging in Humanized Mice.


Keywords

  • aging
  • human
  • humanized mouse
  • recent thymic emigrants
  • thymus involution


Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34 cells via inhibition of senescence.


Keywords

  • HSC stemness maintenance
  • Stem Regenin 1
  • cellular senescence
  • ex vivo expansion
  • human cord blood CD34+ cells
  • mammalian target of rapamycin complex 1
  • p38 mitogen-activated protein kinase α


Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Choroid
  • Endothelial Cells
  • Female
  • Gene Expression Regulation
  • Humans
  • Infant
  • Infant, Newborn
  • Inflammation
  • Inflammation Mediators
  • Macular Degeneration
  • Male
  • Middle Aged
  • Phenotype
  • Sequence Analysis, RNA
  • Single-Cell Analysis

Keywords

  • Age-related macular degeneration
  • Choriocapillaris
  • Choroid
  • Infant
  • Pericytes
  • Single-cell


Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes.


Keywords

  • aging
  • autophagy
  • bone marrow injury
  • mesenchymal stem cells
  • repair


Immune cell extracellular vesicles and their mitochondrial content decline with ageing.


Keywords

  • Ageing
  • Apoptotic bodies
  • Exosomes
  • Extracellular vesicles
  • Immune cells
  • Immunosenescence
  • Inflammageing
  • Microvesicles
  • Mitochondria


Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Carcinoma, Squamous Cell
  • Female
  • Humans
  • Immunohistochemistry
  • Immunosenescence
  • Macrophages
  • Male
  • Middle Aged
  • Mouth Neoplasms
  • Neovascularization, Pathologic
  • Receptors, Cell Surface
  • Tumor Microenvironment

Keywords

  • M1 and M2 macrophages
  • angiogenesis
  • immunohistochemistry
  • immunosenescence
  • oral squamous cell carcinoma

CD36[править]

Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.


Keywords

  • Osteopontin
  • aging
  • lipid metabolism
  • nonalcoholic fatty liver disease
  • p53
  • senescence


Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number.


Keywords

  • CD36 scavenger receptor
  • alpha-tocopherol
  • exosomes
  • extracellular vesicles
  • gene expression
  • lysosome
  • senescence
  • signal transduction
  • vitamin E


Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.


Keywords

  • Aging
  • Macrophages
  • Microglia
  • Oligodendrocyte progenitor cells
  • Phagocytosis
  • Remyelination

CD38[править]

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.


Keywords

  • CD38 NADase
  • NAD metabolism
  • mitochondrial impairment
  • replicative senescence
  • telomere biology disorders


TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways.


Keywords

  • aging
  • chronic inflammation
  • lung
  • network analysis
  • senescence
  • tissue remodeling


Aging alters acetylation status in skeletal and cardiac muscles.


Keywords

  • Aging
  • CD38
  • Deacetylation
  • NAD+
  • PARP
  • SIRT
  • Skeletal muscle


CD38 in Neurodegeneration and Neuroinflammation.


Keywords

  • ALS.
  • Alzheimer’s disease
  • CD38
  • NAD
  • Parkinson’s disease
  • aging
  • neurodegeneration
  • neuroinflammation


CD38, a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies.


MeSH Terms

  • ADP-ribosyl Cyclase 1
  • Aging
  • Animals
  • Antibodies, Monoclonal
  • B-Lymphocytes, Regulatory
  • Cell Line
  • Extracellular Vesicles
  • Humans
  • Infections
  • Membrane Glycoproteins
  • Mice
  • Neoplasms
  • T-Lymphocytes, Regulatory

Keywords

  • CD38
  • adenosine
  • immune-modulation
  • regulatory cells


CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway.


Keywords

  • CD38
  • D-galactose
  • NAD+
  • heart senescence
  • oxidative stress

CD4[править]

Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.


Keywords

  • GEO database
  • bioinformatics
  • biomarker
  • immune cell infiltration
  • ovarian aging


Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells.


Keywords

  • T-cell
  • T-cell homeostasis
  • aging
  • chromatin accessibility
  • epigenetics
  • ribosomal proteins


IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging.


Keywords

  • Candida
  • Foxp3
  • IL-1β
  • Treg
  • Treg17
  • aging
  • fungal infection
  • senescence


Thymus involution sets the clock of declined immunity and repair with aging.


Keywords

  • Aging
  • Chronic systemic inflammation
  • Dysregulated CD4 T cells
  • Immune-mediated repair
  • Thymus


Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.


Keywords

  • HIV
  • exhaustion
  • food insecurity
  • immune activation
  • senescence


Rapamycin Eyedrops Increased CD4 Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.


Keywords

  • aging
  • dry eye
  • goblet cell
  • inflammation
  • lacrimal gland
  • ocular surface
  • rapamycin


Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.


Keywords

  • NAC
  • T cells
  • aging
  • antioxidants
  • immunosenescence
  • vaccination
  • vitamin C


Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.


Keywords

  • Aging
  • Cardiovascular events
  • Chronic kidney disease
  • Comorbidities
  • HIV


Impact of age on CD4 recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.


Keywords

  • Elders on antiretroviral drugs
  • HIV and aging
  • HIV treatment outcomes
  • Sub-saharan Africa


hPMSCs protects against D-galactose-induced oxidative damage of CD4 T cells through activating Akt-mediated Nrf2 antioxidant signaling.


Keywords

  • Aging
  • CD4+ T cells
  • Nrf2
  • Oxidative stress
  • Senescence-associated secretoryphenotype
  • hPMSC


Substantial gap in primary care: older adults with HIV presenting late to care.


Keywords

  • Aging population
  • HIV
  • Older adults
  • Risk
  • Stigma
  • Testing


Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.


Keywords

  • HIV—human immunodeficiency virus
  • Parkinson’s disease
  • aging
  • fine motor activities
  • motor control


Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.


Keywords

  • HIV
  • T cell
  • aging
  • immune activation
  • immune dysfunction
  • inflammation
  • monocyte


HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.


Keywords

  • Affective
  • Aging
  • Aids
  • Compassion
  • Reflective


CD8 T cells are present at low levels in the white matter with physiological and pathological aging.


Keywords

  • aging
  • neuroscience
  • pathology


Immunotherapy in older patients with cancer.


Keywords

  • Ageing
  • Cancer
  • Elderly
  • Immunosenescence
  • Immunotherapy
  • Old people
  • Oncogeriatry


Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.


Keywords

  • CD4 T cell
  • Cell longevity
  • Gene
  • Genetic programs
  • Memory T cell
  • Memory cell markers


Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.


Keywords

  • T cell
  • aging
  • autologous stem cell transplant
  • metabolism
  • myeloma


Immunosenescence: the role of age in multiple sclerosis.


Keywords

  • Ageing
  • Envejecimiento
  • Esclerosis múltiple
  • Esclerosis múltiple de comienzo tardío
  • Immunosenescence
  • Inmunosenescencia
  • Late-onset multiple sclerosis
  • Multiple sclerosis


Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.


Keywords

  • aged
  • senescence
  • thymus
  • transplantation
  • umbilical cord mesenchymal stem cells


Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients.


MeSH Terms

  • Aged, 80 and over
  • Antigens, CD
  • Betacoronavirus
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • COVID-19
  • Coronavirus Infections
  • Cytotoxins
  • Female
  • Humans
  • Immunity, Cellular
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • SARS-CoV-2
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Cytotoxic

Keywords

  • CD4+
  • CD8+
  • COVID-19
  • PD-1
  • SARS-CoV-2
  • aging
  • cytotoxic T cells
  • granzyme
  • perforin


What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?


Keywords

  • Antibodies
  • Antibody-dependent enhancement
  • CD8 T-cells
  • COVID-19
  • Durable immunity
  • Protective immunity
  • SARS
  • SARS-CoV-2
  • T cell lifespan
  • T-cell epitopes
  • T-cells
  • Vaccines
  • Yellow Fever Vaccine


Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.


Keywords

  • HIV
  • Sirtuin 1
  • hematopoietic progenitor cells
  • period circadian clock 2
  • senescence
  • telomere length


COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.


Keywords

  • ACE2
  • C-reactive protein
  • COVID-19
  • Immunity
  • Immunosenescence
  • Interleukin-6
  • Lymphocytes
  • Renin-angiotensin system
  • Severe acute respiratory syndrome coronavirus 2
  • Spain


Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.


Keywords

  • immunosenescence
  • lymphocyte compartments
  • physical performance
  • sarcopenia
  • very old adults


Homeostasis and the functional roles of CD4 Treg cells in aging.


Keywords

  • Aging
  • Autoimmunity
  • Cancer
  • FOXP3
  • Immune senescence
  • Immune suppression
  • Inflammaging
  • Regulatory T cells
  • T helper 17
  • Treg


A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.


Keywords

  • A2 beta-casein
  • SCFAs
  • elderly
  • gut inflammation
  • gut microbiota
  • gut morphology
  • immunosenescence


Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.


Keywords

  • Hemodialysis
  • Inflammation
  • Mortality
  • T cell aging
  • naïve T cells


In-depth immune cellular profiling reveals sex-specific associations with frailty.


Keywords

  • Frailty
  • Healthy aging
  • Immune cellular profiling
  • Immune homeostasis
  • Immunosenescence
  • Sex-specific immune profile


CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.


Keywords

  • CD70
  • T cell aging
  • co-inhibitory molecules
  • immunosenescence
  • overwhelming inflammatory responses


Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.


MeSH Terms

  • Adult
  • Chronic Disease
  • Cohort Studies
  • Comorbidity
  • Female
  • HIV Infections
  • Humans
  • Insurance, Health
  • Life Expectancy
  • Male
  • Middle Aged


Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.


Keywords

  • aging
  • dry eye
  • inflammation
  • lacrimal glands
  • meibomian glands
  • oxidative stress
  • senescence


Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.


Keywords

  • senescence
  • thymic epithelial cells
  • thymocytes


CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.


Keywords

DKC1

PARN

  • Dyskeratosis Congenita
  • primary immunodeficiency
  • senescence
  • telomere


Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.


Keywords

  • Aging
  • Astrocytes
  • Environmental enrichment
  • Microglia
  • Physical exercise
  • T cells


Viral and host factors related to the clinical outcome of COVID-19.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Asymptomatic Infections
  • Betacoronavirus
  • COVID-19
  • China
  • Cohort Studies
  • Coronavirus Infections
  • Critical Illness
  • Disease Progression
  • Evolution, Molecular
  • Female
  • Genetic Variation
  • Genome, Viral
  • Hospitalization
  • Host-Pathogen Interactions
  • Humans
  • Inflammation Mediators
  • Interleukin-6
  • Interleukin-8
  • Lymphocyte Count
  • Lymphopenia
  • Male
  • Middle Aged
  • Pandemics
  • Phylogeny
  • Pneumonia, Viral
  • Respiratory Distress Syndrome
  • SARS-CoV-2
  • T-Lymphocytes
  • Time Factors
  • Treatment Outcome
  • Virulence
  • Virus Shedding
  • Young Adult
  • Zoonoses


Use of comedications and potential drug-drug interactions in people living with HIV in China.


Keywords

  • Aging
  • China
  • Co-medication
  • Drug-drug interaction
  • HIV


CD4 T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Line, Tumor
  • Cell Movement
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Animal
  • NF-kappa B
  • Neoplasm Invasiveness
  • PC-3 Cells
  • Prostatic Neoplasms
  • Th17 Cells

Keywords

  • CD4+ T cell-secreted factors
  • PCa cells
  • Th17 cytokines
  • aging
  • inflammation


The Rules of Human T Cell Fate [i]in vivo[/i].


Keywords

  • decision
  • fate
  • half-life
  • labeling
  • lifespan
  • lymphocyte
  • mathematical model
  • proliferation


CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.


Keywords

  • CD4/CD8 ratio
  • HIV
  • aging
  • comorbidities


The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.


MeSH Terms

  • Adult
  • Aging
  • Animals
  • Female
  • Humans
  • Live Birth
  • Mice
  • Mice, Transgenic
  • Placenta
  • Pregnancy
  • T-Lymphocyte Subsets

Keywords

  • birth weight
  • neonate
  • offspring
  • pregnancy
  • preterm labor


Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.


Keywords

  • age-related involution
  • aging
  • immune system
  • immunomorphology
  • mesenteric lymph nodes


Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.


MeSH Terms

  • Adult
  • Cognition
  • Cross-Sectional Studies
  • HIV Infections
  • Health Literacy
  • Humans
  • Neuropsychological Tests
  • Self Report

Keywords

  • Adherence
  • Aging
  • Cognitive impairment
  • HIV/AIDS
  • Health illiteracy
  • Observational study


Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.


Keywords

  • Stat3
  • immune checkpoint blockade
  • immunotherapy
  • oncogene addiction
  • senescence


Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.


Keywords

  • Aging
  • Head and neck cancer
  • Immune escape
  • Immunosenescence
  • T cells


Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.


MeSH Terms

  • Aging
  • Animals
  • Antigens, CD
  • CD4-Positive T-Lymphocytes
  • Gene Expression Profiling
  • HIV Infections
  • Humans
  • Immunologic Memory
  • Intercellular Signaling Peptides and Proteins
  • Mice
  • Precursor Cells, T-Lymphoid
  • Thymus Gland
  • Wnt Signaling Pathway
  • beta Catenin


Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.


MeSH Terms

  • Anti-HIV Agents
  • CD4 Lymphocyte Count
  • Comorbidity
  • Cost-Benefit Analysis
  • HIV Infections
  • Health Care Costs
  • Humans
  • Life Expectancy
  • United States


Sex Differences in People Aging With HIV.


MeSH Terms

  • Aged
  • Aging
  • Alcohol Drinking
  • Body Composition
  • CD4 Lymphocyte Count
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Frailty
  • HIV Infections
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength
  • Prospective Studies


Identification of Differentially Expressed miRNAs in the Response of Spleen CD4 T Cells to Electroacupuncture in Senescence-Accelerated Mice.


MeSH Terms

  • Aging
  • Animals
  • Antagomirs
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Cytokines
  • Down-Regulation
  • Electroacupuncture
  • Female
  • Gene Regulatory Networks
  • High-Throughput Nucleotide Sequencing
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs
  • Sequence Analysis, RNA
  • Spleen
  • Up-Regulation

Keywords

  • CD4+ T cell
  • Deep sequencing
  • Electroacupuncture
  • Immunological aging
  • miRNA


Thymus Involution and Intravenous Drug Abuse.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Atrophy
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Calcinosis
  • Case-Control Studies
  • Drug Users
  • Female
  • Forensic Pathology
  • Hepatitis C, Chronic
  • Humans
  • Male
  • Middle Aged
  • Substance Abuse, Intravenous
  • Thymus Gland
  • Young Adult


Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • Brain Chemistry
  • Brain Ischemia
  • CD4-Positive T-Lymphocytes
  • Chemokines
  • Cytokines
  • Female
  • Infarction, Middle Cerebral Artery
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Stroke
  • Treatment Outcome

Keywords

  • Age
  • CD4 T cells
  • CXCL10
  • Inflammation
  • Stroke


Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.


MeSH Terms

  • Aged
  • Aging
  • Anti-HIV Agents
  • HIV Infections
  • Humans
  • Middle Aged


African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.


Keywords

  • HIV
  • aging
  • diabetes mellitus
  • mitochondrial genetics


DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Antihypertensive Agents
  • CD4-Positive T-Lymphocytes
  • Cyclic AMP-Dependent Protein Kinases
  • Cytokines
  • Humans
  • Hypertension
  • Mice
  • Mice, Inbred C57BL
  • Nedd4 Ubiquitin Protein Ligases
  • Prostaglandin D2
  • Receptors, Prostaglandin
  • Signal Transduction
  • Sp1 Transcription Factor
  • Superoxides
  • T-Box Domain Proteins
  • Th1 Cells
  • Ubiquitination

Keywords

  • D-prostanoid receptor 1
  • aging
  • hypertension
  • lymphocyte
  • prostaglandin (PG) D2


An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.


Keywords

  • accelerated aging
  • anti-retroviral therapy
  • frailty
  • frailty index
  • geriatric syndrome
  • human immunodeficiency virus (HIV)
  • multimorbidity
  • vulnerability


Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Drug Administration Schedule
  • Female
  • HIV Infections
  • HIV-1
  • Humans
  • Male
  • Medication Adherence
  • Viral Load
  • Young Adult


Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.


Keywords

  • HIV
  • aging
  • frailty
  • haplotypes
  • mitochondria
  • sarcopenia


Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.


Keywords

  • Aging
  • FoxN1
  • Gallic acid
  • Thymus
  • d-galactose


Mitochondrial mass governs the extent of human T cell senescence.


MeSH Terms

  • Adenosine Triphosphate
  • Adult
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Movement
  • Cell Proliferation
  • Cellular Senescence
  • Glucose
  • Glycolysis
  • Humans
  • Immunosenescence
  • Leukocyte Common Antigens
  • Microscopy, Electron, Transmission
  • Middle Aged
  • Mitochondria
  • Rotenone

Keywords

  • T cell
  • aging
  • metabolism
  • mitochondria
  • senescence


T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Extracellular Vesicles
  • Female
  • Humans
  • Immunosenescence
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • T-Lymphocytes

Keywords

  • T cells
  • aging
  • centenarians
  • extracellular vesicles (EVs)
  • immunosenescence


Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Disease Models, Animal
  • Lymphocytic Choriomeningitis
  • Lymphocytic choriomeningitis virus
  • Mice
  • MicroRNAs

Keywords

  • CD8 effector T cell
  • T cell repertoire
  • antiviral response
  • immune aging
  • immunosenescence
  • microRNA


Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.


Keywords

  • Frascati criteria
  • HAND
  • HIV
  • aging
  • neurocognitive impairment


Age-associated changes in human CD4 T cells point to mitochondrial dysfunction consequent to impaired autophagy.


MeSH Terms

  • Adult
  • Aged
  • CD4-Positive T-Lymphocytes
  • Cell Respiration
  • Humans
  • Immunosenescence
  • Longitudinal Studies
  • Mitochondria
  • Mitophagy
  • Young Adult

Keywords

  • CD4+ T cells
  • aging
  • autophagy
  • mitochondria
  • proteomics


Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.


MeSH Terms

  • Aging
  • CD4-Positive T-Lymphocytes
  • Female
  • Humans
  • Influenza, Human
  • Male
  • Monocytes
  • Sex Characteristics
  • Transcriptome

Keywords

  • CD4(+) T cells
  • aging
  • immune system
  • immunology
  • influenza
  • meta-analysis
  • monocytes
  • multi-cohort analysis
  • sex differences
  • transcriptome


Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.


Keywords

  • ART
  • PLWH
  • aging
  • multimorbidity
  • quality of life


Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.


MeSH Terms

  • Aged
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation
  • Female
  • Humans
  • Immunotherapy
  • Mice

Keywords

  • Aging
  • Immune check-point molecules
  • Immunosenescence
  • Immunotherapy
  • Myeloid derived suppressor cells
  • Oral cancer
  • Regulatory T cells


LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.


MeSH Terms

  • Adjuvants, Immunologic
  • Administration, Intranasal
  • Aging
  • Animals
  • Antibodies
  • Antibody Formation
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Dose-Response Relationship, Immunologic
  • Enterotoxins
  • Female
  • Immunity, Mucosal
  • Immunization
  • Inflammation
  • Influenza A Virus, H1N1 Subtype
  • Lung
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Mast Cells
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections


Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.


Keywords

  • HIV
  • aging
  • frailty
  • metabolic syndrome
  • thymus


Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.


MeSH Terms

  • Aged
  • Aging
  • B-Lymphocyte Subsets
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis, Knee
  • T-Lymphocyte Subsets

Keywords

  • B cell
  • Lymphocyte
  • Osteoarthritis
  • T cell


Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.


MeSH Terms

  • Aging
  • Anti-Retroviral Agents
  • Cardiovascular Diseases
  • Carotid Intima-Media Thickness
  • Cross-Sectional Studies
  • Depression
  • Female
  • HIV Infections
  • Humans
  • Male
  • Middle Aged
  • Neurocognitive Disorders
  • Quality of Life
  • Risk Factors
  • Thailand

Keywords

  • HIV
  • aging
  • carotid intima-media thickness
  • neurocognitive


Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cytokines
  • Female
  • Flow Cytometry
  • Gene Expression
  • HIV Infections
  • HIV-1
  • Hepatitis A Virus Cellular Receptor 2
  • Humans
  • Leukocytes, Mononuclear
  • Male
  • Middle Aged
  • Young Adult
  • gag Gene Products, Human Immunodeficiency Virus

Keywords

  • aging
  • immune checkpoint molecules
  • virus suppression


Age-related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • CD4-Positive T-Lymphocytes
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Interleukin-17
  • Intestinal Mucosa
  • Male
  • Middle Aged
  • Phenotype
  • Th1 Cells
  • Th17 Cells
  • Young Adult

Keywords

  • T helper cells
  • aging
  • gut
  • human


Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.


MeSH Terms

  • Adult
  • Aged
  • Anti-Retroviral Agents
  • Cross-Sectional Studies
  • Darunavir
  • Emtricitabine
  • Female
  • HIV Infections
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • RNA, Viral
  • Raltegravir Potassium
  • Ritonavir
  • Telomere
  • Tenofovir

Keywords

  • HIV infection
  • aging
  • immunosenescence
  • telomere length
  • viral load


Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.


MeSH Terms

  • Adult
  • Cell Differentiation
  • Cell Proliferation
  • Cell Survival
  • Humans
  • T-Lymphocytes
  • Telomerase

Keywords

  • T cell subsets
  • T lymphocytes
  • aging
  • alternative splicing
  • differentiation
  • hTERT
  • proliferation
  • telomerase


Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.


MeSH Terms

  • Aged
  • Aging
  • Brazil
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases
  • Comorbidity
  • Diabetes Mellitus
  • Female
  • HIV Infections
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Neoplasms
  • Polypharmacy

Keywords

  • Brazil
  • HIV
  • aging
  • noncommunicable diseases


Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.


MeSH Terms

  • Adult
  • African Americans
  • Aging
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Female
  • Glycated Hemoglobin A
  • HIV Infections
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neurocognitive Disorders
  • Odds Ratio
  • RNA, Viral
  • Risk Factors
  • Walking Speed

Keywords

  • aging
  • gait speed
  • hemoglobin A1C
  • neurocognitive impairment


Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Anti-HIV Agents
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Comorbidity
  • Cost of Illness
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • HIV Infections
  • Humans
  • Hypertension
  • Malawi
  • Male
  • Middle Aged
  • Noncommunicable Diseases
  • Odds Ratio
  • Prevalence
  • Retrospective Studies
  • Risk Factors

Keywords

  • HIV infection
  • Malawi
  • aging
  • noncommunicable diseases


Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes.


MeSH Terms

  • Aging
  • Animals
  • CD4-Positive T-Lymphocytes
  • High-Throughput Nucleotide Sequencing
  • Immunomodulation
  • Mice
  • Phenotype
  • Sequence Analysis, RNA
  • Single-Cell Analysis
  • T-Lymphocyte Subsets


Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.


MeSH Terms

  • Acquired Immunodeficiency Syndrome
  • Adult
  • Anti-Retroviral Agents
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases
  • Diabetes Mellitus
  • Diagnostic Screening Programs
  • Female
  • HIV Infections
  • HIV-1
  • Haiti
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Male
  • Middle Aged
  • Obesity
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Smoking
  • Survivors

Keywords

  • HIV
  • aging
  • cardiovascular disease
  • hypertension
  • risk assessment

CD44[править]

Hyaluronan goes to great length.


Keywords

  • aging
  • hyaluronan
  • longevity
  • naked mole rat
  • very high molecular weight hyaluronan


Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.


MeSH Terms

  • Animals
  • Apoptosis
  • Cell Cycle Checkpoints
  • Cell Line
  • Cytoprotection
  • Gene Expression Regulation
  • Gene Knockout Techniques
  • Humans
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Longevity
  • Mice
  • Mole Rats
  • Molecular Weight
  • Primary Cell Culture
  • Protein Interaction Maps
  • RNA-Seq
  • Signal Transduction
  • Species Specificity
  • Stress, Physiological
  • Tumor Suppressor Protein p53


Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation.


Keywords

  • Aging
  • Articular cartilage
  • Osteoarthritis
  • Plasticity
  • Progenitor cells


Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.


MeSH Terms

  • Aging
  • Animals
  • Dry Eye Syndromes
  • Female
  • Immunologic Memory
  • Mice
  • Mice, Inbred C57BL
  • Th17 Cells


Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.


MeSH Terms

  • Animals
  • B-Lymphocytes
  • Cellular Senescence
  • Circadian Rhythm
  • Disease Models, Animal
  • Humans
  • Hyaluronan Receptors
  • Inflammation
  • Jet Lag Syndrome
  • Longevity
  • Mice
  • Programmed Cell Death 1 Receptor
  • Sequence Analysis, RNA
  • T-Lymphocytes


Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence.


MeSH Terms

  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cytokines
  • Hyaluronan Receptors
  • Mice
  • Mice, Inbred C57BL
  • Phenotype
  • Programmed Cell Death 1 Receptor
  • Proteasome Endopeptidase Complex
  • Receptors, Antigen, T-Cell
  • Signal Transduction

Keywords

  • T cell receptor signal
  • T cell senescence
  • aging
  • proteasome

CD47[править]

Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging.


Keywords

  • CD47
  • aging
  • dSTORM
  • red blood cells
  • thrombospondin-1


CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis.


Keywords

  • CD47
  • aging
  • angiogenesis
  • blood flow
  • endothelial cells
  • glucose homeostasis
  • metabolism
  • self-renewal
  • thrombospondin-1


Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPα Expression.


Keywords

  • CD47
  • T cell exhaustion
  • T cell senescence
  • draining lymph nodes
  • macrophage checkpoint
  • neoadjuvant chemotherapy
  • pancreatic ductal adenocarcinoma
  • signal regulatory protein alpha (SIRPα)
  • spatial heterogeneity
  • tumor microenvironment

CD5[править]

Comparative proteomic analysis identifies biomarkers for renal aging.


Keywords

  • NMN
  • biomarkers
  • glutathionylation
  • proteomics
  • renal aging

CD63[править]

Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function.


Keywords

  • aging
  • extracellular vesicles
  • microRNA
  • plasma
  • senescence
  • senolytic

CD68[править]

Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus.


Keywords

  • Aging
  • Hippocampus
  • Insulin
  • Memory
  • Microglia
  • Neuroinflammation


Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration.


Keywords

  • DNA methyltransferase 1 (DNMT1)
  • aging
  • lumbar disc degeneration (LDD)
  • macrophage polarization
  • transforming growth factor beta 1 (TGFβ1)


Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.


MeSH Terms

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Cellular Senescence
  • Child
  • Germinal Center
  • Humans
  • Hypertrophy
  • Macrophages
  • Palatine Tonsil
  • Recurrence
  • Tonsillectomy
  • Tonsillitis

Keywords

  • Cellular senescence
  • Recurrent tonsillitis
  • Tonsillar hypertrophy


Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle.


Keywords

  • Cellular senescence
  • Endurance
  • Ergogenic aid
  • Inflammation
  • Macrophage


Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats.


MeSH Terms

  • Actins
  • Animals
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Cell Movement
  • Fibroblasts
  • Granulation Tissue
  • Immunohistochemistry
  • Macrophages
  • Models, Animal
  • Neovascularization, Physiologic
  • RNA, Messenger
  • Rats, Wistar
  • Re-Epithelialization
  • Skin
  • Time Factors
  • Transforming Growth Factor beta1
  • Vascular Endothelial Growth Factor A
  • Wound Healing
  • Wounds and Injuries

Keywords

  • TGFb1
  • VEGF
  • gene expression
  • immunohistochemistry
  • wound aging

CD80[править]

The aging common marmoset's immune system: From junior to senior.


MeSH Terms

  • Aging
  • Animals
  • CD4-CD8 Ratio
  • Callithrix
  • Female
  • Flow Cytometry
  • Immune System
  • Longevity
  • Male
  • Models, Animal
  • Sex Factors

Keywords

  • aging
  • common marmoset
  • immune system
  • immunosenescence
  • innate and adaptive immunity
  • sex

CD81[править]

Ovarian aging increases small extracellular vesicle CD81 release in human follicular fluid and influences miRNA profiles.


Keywords

  • extracellular vesicles
  • follicular fluid
  • microRNAs
  • reproductive aging


Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature.


Keywords

  • aging
  • biomarkers
  • exosomes
  • mitochondrial dynamics
  • mitochondrial quality control
  • mitochondrial-derived vesicles (MDVs)
  • mitochondrial-lysosomal axis
  • mitophagy


Increased production of functional small extracellular vesicles in senescent endothelial cells.


Keywords

  • endothelium
  • exosomes
  • extracellular vesicles
  • senescence

CDA[править]

Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • China
  • Cross-Sectional Studies
  • England
  • Female
  • Health Behavior
  • Health Status Disparities
  • Humans
  • Longevity
  • Male
  • Mexico
  • Middle Aged
  • Regression Analysis
  • Self Report
  • Sex Factors
  • Social Class
  • Social Welfare
  • United States

Keywords

  • Cumulative dis/advantage
  • cross-national study
  • health retirement study
  • welfare state theory


Does numerical similarity alter age-related distractibility in working memory?


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Alpha Rhythm
  • Attention
  • Evoked Potentials
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Memory, Short-Term
  • Young Adult

CDC20[править]

Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.


Keywords

  • Cdc20 proteins
  • M phase cell cycle checkpoints
  • aging
  • chromosomal instability
  • chromosome segregation
  • genomic instability
  • premature

CDC25A[править]

Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage.


Keywords

  • Babam2
  • DNA damage
  • cell cycle
  • embryonic stem cells
  • pluripotency
  • senescence

CDC42[править]

Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aging
  • Animals
  • Cell Cycle Proteins
  • Cell Size
  • Endothelial Cells
  • Female
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Middle Aged
  • Neovascularization, Physiologic
  • Primary Cell Culture
  • Transcription Factors
  • cdc42 GTP-Binding Protein

Keywords

  • aging
  • angiogenesis
  • cell proliferation
  • cell size
  • senescence

CDH1[править]

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.


Keywords

  • Cdc6
  • cytoplasmic Cdc6
  • pancreatic cancer
  • senescence
  • subcellular localisation

CDK1[править]

MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging.


MeSH Terms

  • CDC2-CDC28 Kinases
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin B
  • Gene Expression Regulation, Developmental
  • Humans
  • Mesenchymal Stem Cells
  • MicroRNAs
  • Transcriptome
  • Tumor Suppressor Protein p53
  • Umbilical Cord

Keywords

  • Cell proliferation
  • Cell senescence
  • Cellular ageing
  • Human Mesenchymal stem / stromal cells
  • miRNA-mRNA integration

CDK2[править]

p57 is a master regulator of human adipose derived stem cell quiescence and senescence.


Keywords

  • Human adipose derived stem cells
  • Quiescence
  • Senescence
  • p57(Kip2)

CDK4[править]

Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.


Keywords

  • adipogenesis
  • inflammation
  • insulin sensitivity
  • obesity
  • oxidative activity
  • senescence
  • type 2 diabetes


Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.


Keywords

  • Chinese medicine
  • Guilu Erxian Glue
  • bone marrow suppression
  • hematopoietic stem cell senescence
  • p16INK4a

CDK5[править]

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence.


MeSH Terms

  • Aging
  • Animals
  • Cell Cycle
  • Cell Death
  • Cellular Senescence
  • Cyclin-Dependent Kinase 5
  • Excitatory Postsynaptic Potentials
  • Gene Expression
  • Glycolysis
  • Hexokinase
  • Hyperinsulinism
  • Inhibitory Postsynaptic Potentials
  • Insulin
  • Insulin Resistance
  • Liraglutide
  • Male
  • Maze Learning
  • Metformin
  • Mice
  • Neurons
  • Phosphotransferases
  • Primary Cell Culture
  • Protein-Serine-Threonine Kinases
  • Ubiquitination
  • beta Catenin

CDK6[править]

Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6.


Keywords

  • cyclin-dependent kinase 6 (CDK6)
  • high-fat diet (HFD)
  • miR-34a
  • palmitate acid (PA)
  • senescence


Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.


Keywords

  • D-galactose
  • Hydroxysafflor yellow A
  • Oxidative stress
  • Replicative senescence
  • p16


Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells.


Keywords

  • Breast cancer
  • CDK4
  • Cancer stem cells
  • Palbociclib
  • Senescence


Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.


Keywords

  • 17AAG
  • Hsp90
  • cancer
  • p16INK4a
  • senescence
  • tumor suppressor

CDKN1A[править]

Involvement of CDKN1A (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development.


Keywords

  • Cdkn1a
  • Heat stress
  • Irradiation
  • Preimplantation
  • Senescence
  • p21

CDKN2A[править]

Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study.


Keywords

  • CDKN2A
  • Nrf2
  • aging
  • end-stage renal disease
  • inflammation

CDKN2B[править]

Molecular Genetics and Functional Analysis Implicate [i]CDKN2BAS1-CDKN2B[/i] Involvement in POAG Pathogenesis.


Keywords

  • African Americans
  • CDKN2B-AS1
  • Primary open-angle glaucoma (POAG)
  • senescence
  • trabecular meshwork cells

CFI[править]

Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Happiness
  • Health Status
  • Humans
  • Male
  • Personal Satisfaction
  • Quality of Life

Keywords

  • happiness
  • older adults
  • path analysis
  • psychosocial resources
  • subjective well-being


Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran.


MeSH Terms

  • Aged
  • Aging
  • Cross-Sectional Studies
  • Female
  • Geriatric Assessment
  • Health Status Disparities
  • Humans
  • Iran
  • Male
  • Mental Health
  • Psychometrics
  • Reproducibility of Results
  • Surveys and Questionnaires

Keywords

  • aging
  • factor analysis
  • flourishing
  • reliability
  • validity


The decision about retirement: A scale to describe representations and practices of medical doctors and nurses.


Keywords

  • Aging
  • Job satisfaction
  • Retirement
  • Scale


Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Emotions
  • Family Relations
  • Female
  • Health Status
  • Humans
  • Interpersonal Relations
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Sexual Partners
  • United States


Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population.


Keywords

  • aging
  • life span
  • self-esteem
  • structural equation model
  • validity

CFTR[править]

Exercise Physiology Across the Lifespan in Cystic Fibrosis.


Keywords

  • aging
  • cystic fibrosis
  • exercise capacity
  • exercise prescription
  • pediatric


Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.


MeSH Terms

  • Aging
  • Animals
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Gene Expression
  • Inhalation Exposure
  • Mice
  • Mice, Knockout
  • Pulmonary Emphysema
  • Tobacco Smoke Pollution

Keywords

  • Aging
  • CFTR
  • Emphysema
  • Smoking

CGA[править]

Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial.


Keywords

  • Comprehensive geriatric assessment
  • Geriatrics
  • Preoperative chemoradiotherapy
  • Rectal cancer


The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway.


Keywords

  • chlorogenic acid
  • heme oxygenase-1
  • nuclear factor erythroid 2-related factor 2
  • vascular senescence


Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods.


Keywords

  • Comprehensive geriatric assessment
  • Geriatrics
  • Japanese diagnosis procedure combination database
  • Length of stay
  • Mortality
  • Stroke


Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis.


Keywords

  • Aging
  • comprehensive geriatric assessment
  • delirium
  • functional status
  • outcomes
  • surgery


A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-CGA).


Keywords

  • aging
  • comprehensive geriatric assessment (CGA)
  • electronic assessment tools
  • frailty
  • frailty index
  • healthcare
  • older adults


Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team.


Keywords

  • clinical frailty scale
  • frail older adults
  • geriatrics
  • hospital medicine


Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cardiac Surgical Procedures
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Humans
  • Percutaneous Coronary Intervention
  • Risk Assessment
  • Transcatheter Aortic Valve Replacement

Keywords

  • Cardiac surgery
  • Comprehensive geriatric assessment
  • Disability
  • Elderly
  • Frailty
  • Geriatrics
  • Surgical risk scores
  • TAVI


Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study.


MeSH Terms

  • Aged
  • Clinical Competence
  • Education, Medical, Graduate
  • Educational Measurement
  • Female
  • Geriatric Assessment
  • Geriatrics
  • Humans
  • Male
  • Pilot Projects
  • United Kingdom

Keywords

  • Comprehensive geriatric assessment
  • development
  • entrustable professional capabilities
  • objective structured clinical examination
  • summative assessment


How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Female
  • Genital Neoplasms, Female
  • Geriatric Assessment
  • Gynecology
  • Humans
  • Hysterectomy
  • Japan
  • Lymph Node Excision
  • Oncologists
  • Surveys and Questionnaires

Keywords

  • Comprehensive geriatric assessment
  • Elderly
  • Geriatrics
  • Gynecologic cancer


Validation of the Pictorial Fit-Frail Scale in a memory clinic setting.


Keywords

  • aging
  • dementia
  • frail elderly
  • frailty
  • psychometrics


Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging
  • Cognition
  • Female
  • Geriatrics
  • Humans
  • Hyponatremia
  • Male
  • Mental Status and Dementia Tests
  • Middle Aged
  • Motor Activity
  • Sodium


Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Emergency Service, Hospital
  • Female
  • Geriatric Assessment
  • Health Status
  • Hospitalization
  • Humans
  • Internal Medicine
  • Length of Stay
  • Male
  • Mass Screening
  • Patient Discharge
  • Risk Assessment

Keywords

  • CGA
  • Cutoff
  • Geriatrics
  • ISAR
  • Internal medicine
  • Older in-patients
  • Risk screening
  • Sensitivity
  • Specificity

CHI3L1[править]

Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels.


Keywords

  • Aging
  • Alzheimer’s disease
  • Bioinformatics
  • CHI3L1
  • Chitinase
  • NRGN

CHRNA7[править]

Associations between genetic variations and global motion perception.


MeSH Terms

  • Adult
  • Differential Threshold
  • Female
  • Genotype
  • Humans
  • Male
  • Motion Perception
  • Polymorphism, Single Nucleotide
  • Receptors, Nicotinic
  • Sensory Thresholds
  • Young Adult
  • alpha7 Nicotinic Acetylcholine Receptor

Keywords

  • Aging
  • CHRNA7
  • Cholinergic system
  • Coherent motion
  • Genetic variations

CHSY1[править]

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice.


MeSH Terms

  • Age Factors
  • Animals
  • Apoptosis
  • Chondroitin Sulfates
  • Female
  • Glucuronosyltransferase
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Multifunctional Enzymes
  • Mutation
  • N-Acetylgalactosaminyltransferases
  • Neurodegenerative Diseases
  • Neurons
  • Protein Processing, Post-Translational
  • Proteins
  • Retinal Degeneration

Keywords

  • aging
  • chondroitin sulfate synthase
  • hippocampus
  • inflammation
  • mouse
  • myeloid cells
  • neurodegeneration
  • retina
  • retinal pigment epithelium
  • subretinal space

CISD2[править]

CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia.


Keywords

  • CISD2
  • M1/M2 microglia polarization
  • aging
  • anti-inflammatory effects
  • neurodegenerative disease and dementia

CIT[править]

Effect of sex on aging-related decline of dopamine transporter in healthy subjects.


Keywords

  • 123I-FP-CIT
  • Aging
  • Dopamine plasma membrane transport proteins
  • SPECT
  • Sex


The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging.


Keywords

  • SPECT
  • Wechsler Adult Intelligence Scale
  • aging
  • cognitive function
  • dopamine transporter
  • verbal function

CLEC3B[править]

CLEC3B p.S106G Mutant in a Caucasian Population of Successful Neurological Aging.


Keywords 

         APOE
       

         CLEC3B
  • Aging
  • Human genetics
  • Human health

COL1A1[править]

Remodeling process in bone of aged rats in response to resistance training.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Bone Remodeling
  • Gene Expression Regulation
  • Male
  • Physical Conditioning, Animal
  • RNA, Messenger
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Resistance Training

Keywords

  • Aging
  • Bone homeostasis
  • Function
  • Resistance training

COL3A1[править]

Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.


MeSH Terms

  • Aging
  • Animals
  • Breeding
  • Defensins
  • Endometrium
  • Female
  • Fibrosis
  • Gene Expression
  • Horses
  • Inflammation
  • Reverse Transcriptase Polymerase Chain Reaction

Keywords

  • Defensin-β
  • Endometrium
  • Gene expression
  • Immune-modulation
  • Mare

COMT[править]

The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain.


MeSH Terms

  • Acetone
  • Aging
  • Animals
  • Behavior
  • Biogenic Monoamines
  • Capsaicin
  • Chronic Pain
  • Disease Models, Animal
  • Male
  • Mice, Inbred C57BL
  • Peripheral Nerve Injuries
  • Physical Stimulation
  • Prefrontal Cortex
  • Sensory Thresholds

Keywords

  • Geriatric pain
  • Healthy aging
  • Mice
  • Sensory thresholds
  • Supraspinal plasticity
  • Tonic and chronic pain response

COPE[править]

Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the COPE-study.


Keywords

  • Cognitive function
  • End stage renal disease
  • Geriatric assessment
  • Geriatrics
  • Older patients

CORT[править]

Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats.


Keywords

  • aging
  • body composition
  • energy metabolism
  • metabolism-related hormone
  • sex differences


Effects of age and social isolation on murine hippocampal biochemistry and behavior.


Keywords

  • Aging
  • Hippocampus
  • Inflammation
  • Memory
  • Serotonin
  • Social isolation
  • Stress


Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.


Keywords

  • Alzheimer’s disease
  • aging
  • cognitive function
  • enzyme regulation
  • inflammation
  • neurosteroid
  • progesterone
  • steroid hormones


Sex- and age-dependent differences in the hormone and drinking responses to water deprivation.


MeSH Terms

  • Age Factors
  • Animals
  • Arginine Vasopressin
  • Behavior, Animal
  • Dehydration
  • Drinking
  • Female
  • Male
  • Rats, Wistar
  • Sex Factors
  • Sodium Chloride
  • Subfornical Organ
  • Water Deprivation

Keywords

  • aging
  • hormonal response
  • sex differences
  • sodium appetite
  • thirst


Ontogeny of the adrenocortical response in an extremely altricial bird.


MeSH Terms

  • Adrenal Glands
  • Aging
  • Animals
  • Corticosterone
  • Female
  • Hypothalamo-Hypophyseal System
  • Male
  • Parrots
  • Restraint, Physical
  • Stress, Physiological

Keywords

  • Venezuela
  • adrenocortical
  • altricial
  • birds
  • corticosterone
  • glucocorticoid
  • hypothalamic-pituitary-adrenal axis
  • ontogeny
  • parrots
  • stress

CP[править]

A Life Course Perspective on Growing Older With Cerebral Palsy.


Keywords

  • aging
  • cerebral palsy
  • midlife
  • neurological disorders
  • neurology
  • qualitative descriptive


The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.


Keywords

  • Aging
  • Alzheimer's disease
  • Choroid plexus
  • Development
  • Multiple sclerosis
  • Neuroprotection


The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation.


Keywords

  • Collagen
  • D-galactose
  • Elastin
  • Skin aging
  • Ultraviolet


Model based strategies towards protein A resin lifetime optimization and supervision.


MeSH Terms

  • Algorithms
  • Chromatography
  • Kinetics
  • Least-Squares Analysis
  • Ligands
  • Models, Theoretical
  • Principal Component Analysis
  • Resins, Plant
  • Staphylococcal Protein A
  • Statistics as Topic

Keywords

  • Cleaning procedures
  • Hybrid modeling
  • Multivariate data analysis
  • Protein A chromatography
  • Resin aging
  • Resin lifetime


The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands.


MeSH Terms

  • Aging
  • Animal Feed
  • Animal Husbandry
  • Animals
  • Cattle
  • Diet
  • Dietary Supplements
  • Ecosystem
  • Female
  • Poaceae
  • Seasons
  • Weather

Keywords

  • beef cattle
  • cow age
  • environment
  • supplement intake
  • winter grazing


Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice.


Keywords

  • Cyclophosphamide
  • Decalepis hamiltonii
  • premature ovarian failure
  • reproductive performance
  • reproductive senescence
  • uterus


Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Asymptomatic Infections
  • Brain
  • Brain Diseases
  • Clostridium Infections
  • Clostridium perfringens
  • Disease Models, Animal
  • Feces
  • Food Microbiology
  • Gene Expression
  • Humans
  • Inflammation
  • Intestines
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Organ Size
  • Oxidative Stress
  • Risk Factors
  • Spleen

Keywords

  • Clostridium perfringens
  • brain damage
  • brain disorder
  • gut microbiota


The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Anti-Retroviral Agents
  • Disease Management
  • Disease Transmission, Infectious
  • Female
  • HIV Infections
  • Humans
  • Male
  • Medication Adherence
  • Middle Aged
  • Pharmacists
  • Professional Role
  • Treatment Outcome

Keywords

  • Aging
  • Antiretroviral therapy
  • Clinical pharmacist
  • Comorbidities
  • HIV


A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis.


MeSH Terms

  • Adult
  • Aging
  • Case-Control Studies
  • Cross-Sectional Studies
  • Humans
  • Middle Aged
  • Pain
  • Pain Measurement
  • Pancreatitis, Chronic
  • Sex Factors

Keywords

  • Central sensitization
  • Chronic pancreatitis
  • Nociception
  • Pain


Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators.


Keywords

  • Aging
  • DXA
  • Fracture prevention
  • Injury/fracture healing
  • Osteoporosis


Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients.


Keywords

  • Clinical pharmacy
  • geriatrics
  • inpatients
  • polypharmacy
  • risk stratification


Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide.


MeSH Terms

  • Aging
  • Amino Acids
  • Animals
  • Body Weight
  • Collagen
  • Drosophila
  • Fatty Acids
  • Feeding Behavior
  • Hydrogen Peroxide
  • Longevity
  • Molecular Weight
  • Oxidative Stress
  • Paraquat

Keywords

  • Anti-aging
  • Antioxidant activity
  • Collagen
  • Drosophila
  • Royal jelly

CPM[править]

Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults.


Keywords

  • Aging
  • Anxiety
  • Conditioned Pain Modulation
  • Pain Catastrophizing
  • Reliability
  • Temporal Summation of Pain


Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.


Keywords

  • Aging
  • CPM duration
  • Conditioned pain modulation
  • Conditioning stimulus
  • Sex differences
  • Test stimulus


The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation.


Keywords

  • Aging
  • conditioned pain modulation
  • meta-analysis
  • pain modulation
  • temporal summation

CPNE1[править]

Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence.


Keywords

  • CPNE1
  • U2AF1
  • intron retention
  • senescence
  • splicing factor

CPT1A[править]

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells.


Keywords

  • CPT1A
  • Fatty acid
  • Mitochondria
  • Placenta-derived mesenchymal stem cell
  • Senescence

CPT1C[править]

Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function.


Keywords

  • MRC-5 fibroblasts
  • carnitine palmitoyltransferase 1C (CPT1C)
  • cellular senescence
  • lipidomics
  • mitochondrial function


Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.


Keywords

  • carnitine palmitoyltransferase 1C
  • metabolic reprogramming
  • mitochondria
  • senescence
  • stable transfection

CPT2[править]

The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats.


Keywords

  • EGCG
  • free fatty acid
  • high-fat dietary
  • lifespan
  • proteomics
  • transcriptome

CR1[править]

Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age.


Keywords

  • Aging
  • Alzheimer’s disease
  • middle aged
  • neuroimaging
  • single nucleotide

polymorphism


The whale shark genome reveals how genomic and physiological properties scale with body size.


MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Base Sequence
  • Body Size
  • Genome
  • Genomics
  • Longevity
  • Sharks
  • Temperature

Keywords

  • body size
  • lifespan
  • metabolic rate
  • neural genes
  • whale shark

CRABP2[править]

Preconception resveratrol intake against infertility: Friend or foe?


Keywords

  • aging
  • assisted reproductive technology
  • infertility
  • resveratrol
  • sirtuin

CRBN[править]

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Aging
  • Aniline Compounds
  • Animals
  • Blood Platelets
  • Cell Line
  • Cellular Senescence
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Models, Animal
  • Primary Cell Culture
  • Proteolysis
  • Sulfonamides
  • Ubiquitin-Protein Ligases
  • bcl-X Protein

CRP[править]

Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults.


Keywords

  • Muscle wasting
  • aging
  • anabolic resistance
  • inflammation
  • resistance training
  • sarcopenia


Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.


Keywords

  • Angiopoietin-like protein (ANGPTL) 2
  • Cardio-ankle vascular index (CAVI)
  • Chronic inflammation
  • Hemodialysis
  • Senescence


Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients.


Keywords

  • Aging
  • Cardiovascular prevention
  • Exercise-based cardiac rehabilitation


rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient.


Keywords

  • COVID-19
  • False negative reactions
  • Geriatrics
  • Mass screening
  • Reverse transcriptase polymerase chain reaction
  • SARS-CoV-2
  • Tomography


The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.


Keywords

  • aging
  • growth differentiation factor 15
  • idiopathic pulmonary fibrosis
  • interstitial lung abnormalities
  • mortality


A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial.


Keywords

  • Functional food
  • aging
  • beta-hydroxy beta-methylbutyrate
  • muscle strength
  • sarcopenia
  • vitamin D


Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.


Keywords

  • Aging
  • Microbial co-occurrences
  • Mucosal microbiome
  • Systemic inflammation


The relationship between frailty and serum alpha klotho levels in geriatric patients.


Keywords

  • Aging
  • Biomarkers
  • Frailty syndrome
  • Geriatric syndrome
  • Sarcopenia


ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.


Keywords

  • ZMPSTE24
  • aging
  • inflammation
  • lamin A/C
  • progerin


Cultural and life style practices associated with low inflammatory physiology in Japanese adults.


Keywords

  • Aging
  • Bathing
  • C-reactive protein
  • Diet
  • Inflammation
  • Interleukin-6
  • Japan
  • Tea


Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis.


Keywords

  • Aging
  • Breg cells
  • Exercise
  • IL-10
  • Rheumatoid arthritis
  • T cells
  • Treg cells


PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.


Keywords

  • Accelerated aging
  • Inflammation
  • Klotho
  • Methylation
  • PTSD


Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood.


Keywords

  • Aging
  • Bereavement
  • C-reactive protein
  • Health
  • Inflammation
  • Widowhood


The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates.


Keywords

  • Aging
  • Bariatric surgery
  • Elderly
  • Obesity
  • Sarcopenia


Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population.


Keywords

  • CRP
  • advanced glycationed end products
  • aging
  • dAGE
  • immunity
  • inflammation


Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes?


Keywords

  • Stroop task
  • aging
  • bimanual coordination
  • inhibition
  • mediation analysis
  • switching


Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis.


Keywords

  • aging
  • post-traumatic chronic osteomyelitis
  • telomere


Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Disease Progression
  • Female
  • Frail Elderly
  • Frailty
  • Geriatric Assessment
  • Humans
  • Independent Living
  • Longitudinal Studies
  • Male
  • Nutrition Assessment
  • Nutritional Status
  • Physical Examination
  • Risk Factors
  • Singapore
  • Socioeconomic Factors

Keywords

  • Frailty
  • longitudinal
  • risk factors
  • transition


Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.


MeSH Terms

  • Aged
  • Aging
  • Cardiovascular Diseases
  • Female
  • Humans
  • Inflammation
  • Male
  • Muscle Strength
  • Obesity
  • Physical Exertion

Keywords

  • Inflammation
  • cardiovascular disease risk factors
  • obesity
  • physical activity
  • physical function


Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Fever of Unknown Origin
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Prospective Studies
  • Young Adult

Keywords

  • Japan
  • aging population
  • elderly
  • erythrocyte sedimentation rate
  • fever of unknown origin
  • prospective studies


Decrease in Serum Vitamin D Level of Older Patients with Fatigue.


MeSH Terms

  • Aged
  • Cohort Studies
  • Fatigue
  • Female
  • Humans
  • Male
  • Middle Aged
  • Vitamin D
  • Vitamin D Deficiency

Keywords

  • aging
  • mental fatigue
  • older
  • physical fatigue
  • sex differences
  • vitamin D


The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Biomarkers
  • C-Reactive Protein
  • CD4-CD8 Ratio
  • Cross-Sectional Studies
  • Female
  • Frail Elderly
  • Frailty
  • Humans
  • Independent Living
  • Interleukin-6
  • Male
  • Middle Aged
  • Thailand

Keywords

  • C-reactive protein
  • Thailand
  • aging
  • cross-sectional study
  • frailty
  • frailty biomarkers
  • fried’s phenotypes
  • interleukin-6


Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study).


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Biomarkers
  • Body Mass Index
  • C-Reactive Protein
  • Cognitive Dysfunction
  • Depression
  • Female
  • Follow-Up Studies
  • Geriatric Assessment
  • Hand Strength
  • Homocysteine
  • Humans
  • Independent Living
  • Inflammation
  • Male
  • Mobility Limitation
  • Neuropsychological Tests
  • Prospective Studies
  • Risk Factors
  • Time Factors

Keywords

  • Aging
  • C-reactive protein
  • Homocysteine
  • Inflammation
  • Intrinsic capacity
  • Older adults


Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • C-Reactive Protein
  • England
  • Female
  • Ferritins
  • Fibrinogen
  • Humans
  • Inflammation
  • Loneliness
  • Longitudinal Studies
  • Male
  • Middle Aged

Keywords

  • C-reactive protein
  • Ferritin
  • Fibrinogen
  • Inflammation
  • Loneliness


The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Echocardiography
  • Female
  • Humans
  • Hydrocortisone
  • Inflammation
  • Male
  • Metabolic Syndrome

Keywords

  • Aging
  • Cortisol
  • Inflammation
  • Metabolic syndrome


Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men.


MeSH Terms

  • Adult
  • Biomarkers
  • Blood Pressure
  • C-Reactive Protein
  • Cardiovascular Diseases
  • Circadian Rhythm
  • Diet
  • Energy Intake
  • Fasting
  • Heart Rate
  • Humans
  • Inflammation
  • Male
  • Metabolic Diseases
  • Middle Aged
  • Nutritional Physiological Phenomena
  • Regression Analysis
  • Risk Factors
  • Young Adult

Keywords

  • Aging
  • Health benefits
  • Inflammation
  • Recurrent fasting


Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017).


MeSH Terms

  • Adult
  • Aged
  • Antirheumatic Agents
  • Arthritis, Rheumatoid
  • Arthroplasty, Replacement
  • Arthroplasty, Replacement, Knee
  • Biological Products
  • Drug Utilization
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Postoperative Complications

Keywords

  • C-reactive protein
  • Rheumatoid arthritis
  • aging
  • arthroplasty
  • drug therapy

CS[править]

Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial.


Keywords

  • Exercise
  • aging
  • hypertension
  • hypotension
  • resistance training


Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China.


Keywords

  • Condensation sink
  • Haze
  • New particle formation
  • Photochemical aging
  • Pollution evolution


Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling.


Keywords

  • Accelerated aging
  • Biochar
  • Cadmium
  • Enzyme activity
  • Heavy metal stabilization
  • Soil remediation


Cockayne syndrome proteins CSA and CSB maintain mitochondrial homeostasis through NAD signaling.


Keywords

  • AMPK
  • Cockayne syndrome
  • NAD+
  • accelerated ageing
  • aging
  • mitochondrial maintenance
  • mitophagy


Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study.


Keywords

  • Cognition
  • Cognitive Aging
  • Sensory
  • Vision loss


Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults.


Keywords

  • Aging
  • Functionality
  • Instability resistance training
  • Muscle hypertrophy
  • TRX training


Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity.


Keywords

  • Aging
  • Birth Cohort Effect
  • Contrast Sensitivity
  • Epidemiology
  • Visual Function


Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.


Keywords

  • Aging
  • Cold-sensitive
  • DNA repair
  • Gametogenesis
  • Hydra oligactis
  • Transcriptome


Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Attention
  • Brain Waves
  • Cortical Synchronization
  • Humans
  • Male
  • Norepinephrine
  • Reflex, Pupillary

Keywords

  • cognitive aging
  • locus coeruleus
  • noradrenaline
  • norepinephrine
  • rhythmic neural activity
  • selective attention


Cellular senescence: from anti-cancer weapon to anti-aging target.


MeSH Terms

  • Aging
  • Animals
  • Antineoplastic Agents
  • Breast Neoplasms
  • Cell Proliferation
  • Cell Transformation, Neoplastic
  • Cellular Senescence
  • Cyclin-Dependent Kinases
  • Drug Discovery
  • Female
  • Humans
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyridines

Keywords

  • cancer
  • cellular senescence
  • healthy aging
  • pro-senescence cancer therapy
  • senolytic therapies


Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.


MeSH Terms

  • Aging
  • Animals
  • Calcium Signaling
  • Citrate (si)-Synthase
  • Citric Acid Cycle
  • Female
  • Infertility, Male
  • Male
  • Metabolome
  • Mice
  • Ovum
  • Spermatozoa


Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke.


Keywords

  • Airway inflammation
  • autophagy
  • cellular senescence
  • chronic obstructive pulmonary disease (COPD)
  • necroptosis
  • oxidative stress


Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease.


MeSH Terms

  • Aging
  • Amyloidogenic Proteins
  • Animals
  • Biological Evolution
  • Brain
  • Female
  • Humans
  • Inheritance Patterns
  • Models, Neurological
  • Neurodegenerative Diseases
  • Pregnancy
  • Stress, Physiological

Keywords

  • Alzheimer’s disease
  • Parkinson’s disease
  • amyloid cascade hypothesis
  • amyloidogenic proteins
  • antimicrobial protection model
  • cross-seeding
  • evolvability hypothesis


Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice.


MeSH Terms

  • Alveolar Epithelial Cells
  • Animals
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cytokines
  • Emphysema
  • Insulin-Like Growth Factor I
  • Lung
  • Mice, Inbred C57BL
  • Models, Biological
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-akt
  • Pulmonary Disease, Chronic Obstructive
  • RNA, Messenger
  • Signal Transduction
  • Smoking

Keywords

  • Molecular biology
  • Senescence
  • Stem cells

CSF1R[править]

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice.


Keywords

  • CSF1R
  • adipose
  • aging
  • environmental enrichment
  • microglia


Modulation of Microglia by Voluntary Exercise or CSF1R Inhibition Prevents Age-Related Loss of Functional Motor Units.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • Databases, Genetic
  • Humans
  • Induced Pluripotent Stem Cells
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microglia
  • Motor Neurons
  • Muscle, Skeletal
  • Neuromuscular Junction
  • Neuronal Plasticity
  • Physical Conditioning, Animal
  • RNA-Seq
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Spinal Cord

Keywords

  • CSF1R inhibition
  • aging
  • exercise
  • innervation
  • microglia
  • motor unit
  • neuroinflammation
  • neuromuscular junction
  • neuromuscular system
  • spinal cord

CTCF[править]

New targeted approaches for epigenetic age predictions.


Keywords

  • Aging
  • Amplicon sequencing
  • Blood
  • Buccal swabs
  • CTCF
  • DNA methylation
  • Droplet digital PCR
  • Epigenetic
  • Human

CTH[править]

Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers.


Keywords

  • APOE
  • Aging
  • Alzheimer’s disease
  • cerebral blood flow
  • cognition
  • cognitive decline
  • grey matter
  • magnetic resonance imaging
  • tau proteins

CTLA4[править]

Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial.


Keywords

  • CTLA-4
  • Geroscience
  • IL-6
  • Immunosenescence
  • Inflammaging

CTRL[править]

Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity.


Keywords

  • aging
  • critical torque
  • exercise performance
  • group III/IV muscle afferents
  • neuromuscular fatigue


miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity.


Keywords

  • Alzheimer’s disease
  • aging
  • blood
  • miR-146a
  • microRNA
  • plasma


Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men.


Keywords

  • Aging
  • critical torque
  • group III/IV muscle afferents

CTSA[править]

A CTSA-based consultation service to advance research on special and underserved populations.


Keywords

  • faculty development
  • geriatrics
  • grant review
  • grant studio
  • pediatrics
  • peer review
  • research consultation service
  • special populations
  • underrepresented minorities

CTSB[править]

Myocardial cathepsin D is downregulated in sudden cardiac death.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cathepsin D
  • Death, Sudden, Cardiac
  • Down-Regulation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardium
  • Substrate Specificity

CX3CL1[править]

Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice.


Keywords

  • Aging
  • CX3CL1
  • Cognition
  • Fractalkine
  • Long-term potentiation
  • Microglia
  • Neurodegeneration
  • Neurogenesis
  • Neuroinflammation

CX3CR1[править]

Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism.


Keywords

  • DNA methylation
  • aging
  • glucose metabolism
  • monocytes
  • phosphatidylcholines
  • transcriptome


Muscle Injury Induces Postoperative Cognitive Dysfunction.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Brain-Derived Neurotrophic Factor
  • CX3C Chemokine Receptor 1
  • Cytokines
  • Disease Models, Animal
  • Hippocampus
  • Humans
  • Male
  • Mice
  • Microglia
  • Muscle, Skeletal
  • Nerve Growth Factor
  • Postoperative Cognitive Complications
  • Postoperative Complications

CXCL1[править]

Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines.


Keywords

  • SASP
  • cytokines
  • inflammation
  • paralysis
  • senescence
  • spinal cord injury


Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.


MeSH Terms

  • Adult
  • Aging
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Biomarkers
  • CD4 Lymphocyte Count
  • Computational Biology
  • Cross-Sectional Studies
  • Disease Susceptibility
  • Duration of Therapy
  • Female
  • HIV Infections
  • Humans
  • Inflammation
  • Male
  • Metabolome
  • Metabolomics
  • Middle Aged
  • Proteomics
  • Telomere Homeostasis
  • Viral Load

Keywords

  • HIV
  • India
  • LMIC (lower middle income country)
  • inflammation markers
  • long term antiretroviral therapy

CXCL10[править]

Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration.


Keywords

  • Aging
  • CXCL10
  • IFN-γ
  • Macrophage
  • Muscle regeneration
  • Single-cell RNA sequence

CXCL11[править]

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells.


Keywords

  • CXCL11
  • Endothelial cells
  • Therapy-induced senescence
  • Tumor microenvironment

CXCL12[править]

Co-option of Neutrophil Fates by Tissue Environments.


Keywords

  • angiogenesis
  • immune heterogeneity
  • immune niche
  • innate immunity
  • neutrophil lifespan
  • neutrophils
  • single-cell analysis
  • tissue-resident cells


Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.


Keywords

  • aging
  • bone marrow
  • cxcl12-abudant reticular cells
  • endothelial cells
  • niche


Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.


MeSH Terms

  • Aging
  • Animals
  • Bone Marrow
  • Bone Marrow Cells
  • Cell Differentiation
  • Cells, Cultured
  • Cellular Microenvironment
  • Chemokine CXCL12
  • Embryonic Development
  • Endothelial Cells
  • Gene Expression Profiling
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Inflammation
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred C57BL
  • Stem Cell Niche
  • Transcriptome

Keywords

  • aging
  • bone marrow microenvironment
  • hematopoietic stem cells
  • inflammation
  • niches
  • stromal cells
  • transcriptomics

CXCL13[править]

RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype.


Keywords

  • CXCR5
  • FastQC
  • RNA-Seq
  • aging
  • choroid
  • mice
  • retina
  • retinal degeneration

CXCL14[править]

Identification of genes associated with endometrial cell aging.


Keywords

  • CXCL12
  • CXCL14
  • IL17RB
  • endometrial cell aging
  • infertility
  • quantitative

immunohistochemistry

CXCL8[править]

Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.


Keywords

  • Alzheimer's disease
  • endothelial senescence
  • gene expression
  • neurofibrillary tangles
  • plasma biomarkers
  • tau pathology
  • vascular dysfunction

CXCL9[править]

CXCL9 and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Brazil
  • Chagas Disease
  • Chemokine CXCL10
  • Chemokine CXCL9
  • Cohort Studies
  • Electrocardiography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Trypanosoma cruzi

Keywords

  • Chagas disease
  • Chemokines
  • Cohort
  • Cytokines
  • Immune biomarkers

CXCR2[править]

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos.


Keywords

  • CXCL5
  • CXCR2
  • SASP
  • aging
  • infertility
  • preimplantation embryo


Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.


Keywords

  • ageing
  • diabetes
  • senescence
  • senolytics
  • wound healing

CXCR3[править]

Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis.


Keywords

  • chemokine
  • hepatocyte
  • natural killer cell
  • senescence

CXCR4[править]

Aging-Related Reduced Expression of CXCR4 on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects.


Keywords

  • Aging
  • CXCR4 and ROS
  • HSPC
  • MSC


Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/CXCR4 signalling pathway.


Keywords

  • BPIFB4
  • Cardiomyopathy
  • Diabetes
  • Gene therapy
  • Longevity


Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage.


MeSH Terms

  • Animals
  • Blood Vessels
  • Brain
  • Cell Line
  • Cellular Senescence
  • Chemokine CXCL12
  • Cranial Irradiation
  • Disease Models, Animal
  • Down-Regulation
  • Endothelial Cells
  • Female
  • Gene Expression Regulation
  • Humans
  • Lipopeptides
  • Mice
  • Receptors, CXCR4
  • Signal Transduction

Keywords

  • CXCR4
  • SDF-1
  • brain disorder
  • endothelial dysfunction
  • ionizing radiation
  • senescence

CYP11B1[править]

Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼.


Keywords

  • CYP11B1
  • CYP17A
  • Cellular senescence
  • Compact and clear cells
  • Cortisol-producing adenoma
  • PRKACA

CYP1A1[править]

Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Cheek
  • Cohort Studies
  • Cytochrome P-450 CYP1A1
  • European Continental Ancestry Group
  • Female
  • Genome-Wide Association Study
  • Humans
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Skin Aging
  • Skin Pigmentation

Keywords

  • Candidate SNPs
  • Chinese Han females
  • GWAS
  • Skin aging

CYP26B1[править]

Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.


MeSH Terms

  • Aging
  • Animals
  • Female
  • Isotretinoin
  • Male
  • Metaplasia
  • Mice
  • Neural Stem Cells
  • Neurogenesis
  • Olfactory Mucosa
  • Olfactory Receptor Neurons
  • Retinoic Acid 4-Hydroxylase

Keywords

  • aging
  • inositol-1,4,5-triphosphate
  • metaplasia
  • olfactory epithelium
  • retinoic acid
  • stem cells

CYP2C19[править]

Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations.


Keywords

  • citalopram
  • genetic polymorphism
  • geriatrics
  • physiologically based pharmacokinetic modeling


Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2D6
  • Drug Prescriptions
  • Female
  • Humans
  • Liver-Specific Organic Anion Transporter 1
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Pharmaceutical Preparations
  • Pharmacogenomic Testing
  • Precision Medicine
  • Primary Health Care
  • United Kingdom

Keywords

  • clinical pharmacology
  • general practice
  • pharmacogenomics

CYP2E1[править]

DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver.


Keywords

  • Aging
  • Cyp2e1
  • DNA methylation
  • Drug metabolism
  • Histone acetylation
  • Pharmacokinetics

CYP7A1[править]

Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.


Keywords

  • Aging
  • Cytochrome P450’s
  • Nuclear receptors
  • Ontogeny
  • Rat liver
  • mRNA/protein expression

DBI[править]

Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries.


Keywords

  • aging
  • cholinergic antagonists
  • drug burden index
  • drug utilization
  • hypnotics and sedatives
  • inappropriate prescribing
  • pharmacoepidemiology


Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study.


Keywords

  • Cognitive function
  • anti-muscarinics
  • benzodiazepines
  • geriatrics
  • longitudinal
  • mobility impairment
  • physical function
  • polypharmacy


Using the Drug Burden Index to identify older adults at highest risk for medication-related falls.


Keywords

  • Accidental falls
  • Aging
  • Health services
  • Medication
  • Medication therapy management


Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention.


Keywords

  • aging
  • community pharmacy
  • falls
  • health services
  • medication

DBP[править]

Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials.


Keywords

  • Aged
  • Aging
  • Exercise
  • Exercise therapy
  • High blood pressure
  • Hypertension
  • Resistance training


Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia.


Keywords

  • Aging
  • Diastolic pressure
  • Handgrip strength
  • Post-exercise muscle ischemia
  • Walking performance


The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years.


Keywords

  • aging
  • blood pressure
  • cognitive performance
  • dementia
  • sex differences


Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia.


Keywords

  • Cognition
  • Diastolic blood pressure
  • Senility


Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study.


MeSH Terms

  • Aged
  • Arterial Pressure
  • Blood Pressure
  • Brain
  • Cohort Studies
  • Diastole
  • Female
  • Frontal Lobe
  • Humans
  • Hypertension
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Organ Size
  • Parietal Lobe
  • Prospective Studies
  • Systole
  • Temporal Lobe
  • White Matter

Keywords

  • American Heart Association
  • blood pressure
  • cerebrovascular disease
  • cognitive aging
  • white matter


Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study.


Keywords

  • Aging
  • Blood pressure
  • Cardiovascular
  • Genetics
  • Single-nucleotide polymorphism


Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS.


MeSH Terms

  • Aged, 80 and over
  • Blood Pressure
  • Blood Pressure Determination
  • China
  • Female
  • Health Surveys
  • Humans
  • Hypertension
  • Longevity
  • Longitudinal Studies
  • Male
  • Prevalence

Keywords

  • Blood pressure
  • Epidemiology
  • Hypertension
  • Oldest-old
  • Prevalence


The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Blood Pressure
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged

Keywords

  • Antihypertensive therapy
  • Birth cohort effect
  • Blood pressure
  • Cohort study
  • Heart disease
  • Survival

DCC[править]

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.


MeSH Terms

  • Adenosine Triphosphatases
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Dosage Compensation, Genetic
  • Gene Expression Regulation
  • Longevity
  • Multiprotein Complexes
  • X Chromosome

Keywords

  • X chromosome dosage compensation
  • aging
  • condensin
  • gene expression
  • higher-order chromosome structure
  • lifespan
  • proteotoxic stress
  • topologically associating domains

DCN[править]

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans.


Keywords

  • IGF-I
  • aging
  • bone marrow mesenchymal stem cell
  • osteoporosis
  • small leucine-rich proteoglycan

DCX[править]

GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice.


Keywords

  • Adult hippocampal neurogenesis
  • Glycogen synthase kinase-3β
  • Senescence


Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats.


Keywords

  • Aging
  • DNA methylation
  • Doublecortin
  • Hippocampus
  • IGF-1R
  • mGluR5

DDB1[править]

DCAF1 regulates Treg senescence via the ROS axis during immunological aging.


Keywords

  • Aging
  • Cellular senescence
  • Immunology
  • Inflammatory bowel disease
  • T cells

DDC[править]

N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease.


MeSH Terms

  • Acetylcysteine
  • Aging
  • Animals
  • Apoptosis
  • Disease Models, Animal
  • End Stage Liver Disease
  • Humans
  • Mice
  • Muscle Fibers, Skeletal
  • Muscular Atrophy
  • Oxidative Stress
  • Pyridines
  • Sarcopenia

Keywords

  • Sarcopenia
  • UPP oxidative stress
  • apoptosis
  • chronic liver disease
  • hepatotoxin.

DDO[править]

New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life.


Keywords

  • Brain aging
  • Cell death
  • L-Glutamate
  • NMDA receptors
  • d-Aspartate
  • d-Aspartate oxidase

DDT[править]

Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia.


Keywords

  • Aging
  • Alzheimer’s disease
  • Auditory processing
  • Cognition
  • Dichotic Digits Test


Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils.


MeSH Terms

  • Animals
  • DDT
  • Hexachlorocyclohexane
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Oligochaeta
  • Polychlorinated Biphenyls
  • Pyrenes
  • Soil Pollutants

Keywords

  • Aging
  • BAFs
  • Bioaccumulation
  • HOCs
  • Laboratory-contaminated soils


Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish.


Keywords

  • Aging
  • Anxiety-related behavior
  • DDT
  • Neurobehavioral toxicology
  • Zebrafish


Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae).


MeSH Terms

  • Animals
  • Anopheles
  • Drug Resistance
  • Female
  • Fertility
  • Insecticides
  • Larva
  • Male
  • Metals
  • Reproduction
  • Water Pollutants

Keywords

  • Anopheles arabiensis
  • Insecticide resistance
  • Longevity
  • Transgenerational effects


Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Chemical and Drug Induced Liver Injury
  • Dichlorodiphenyl Dichloroethylene
  • Down-Regulation
  • Liver
  • Male
  • Mice
  • Oxidative Stress
  • Pesticides
  • Plant Extracts
  • Polyphenols
  • Transcriptome
  • Up-Regulation
  • Vitis

Keywords

  • Aging
  • Hepatoprotection
  • Mus spretus
  • Organochlorine
  • Oxidative damage
  • Pedro-ximénez grape must
  • Transcriptional analysis
  • p,p'-DDE


Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells.


MeSH Terms

  • Adult
  • B-Lymphocytes
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cytokines
  • Dose-Response Relationship, Drug
  • Endosulfan
  • Female
  • Healthy Volunteers
  • Humans
  • Inflammation Mediators
  • Insecticides
  • Killer Cells, Natural
  • Male
  • Primary Cell Culture
  • T-Lymphocytes, Cytotoxic
  • Young Adult

Keywords

  • Endosulfan
  • Immunosenescence
  • NK cells
  • PBMC
  • cytotoxic cells
  • interferon
  • organochlorine pesticide
  • senescence

DKC1[править]

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation.


Keywords

  • DKC1
  • cell death: senescence
  • cirrhosis
  • hepatopulmonary syndrome
  • liver transplantation
  • short telomere syndromes

DLD[править]

A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.


Keywords

  • Alzheimer's disease
  • Down syndrome
  • aging
  • cerebral blood flow
  • neuroimaging

DLGAP2[править]

Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.


Keywords

  • Alzheimer’s
  • Diversity Outbred
  • Dlgap2
  • GWAS
  • aging
  • cognition
  • genetic diversity
  • resilience
  • spines
  • susceptibility
  • translational

DLX5[править]

Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5.


Keywords

  • adipogenic differentiation
  • cell senescence
  • distal-less homeobox 5
  • lysine demethylase 4B
  • mesenchymal stem cells
  • microRNA-27b-3p
  • osteoarthritis pain
  • osteogenic differentiation

DMD[править]

Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients.


Keywords

  • Aging
  • Aldehyde dehydrogenase
  • Dog model
  • Duchenne muscular dystrophy
  • Human
  • Myogenic
  • Non-human primate
  • Skeletal muscle


Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis.


MeSH Terms

  • Female
  • Humans
  • Life Expectancy
  • Male
  • Muscular Dystrophy, Duchenne
  • Parturition
  • Pregnancy
  • Prognosis
  • Quality of Life
  • Respiration, Artificial
  • Survival

Keywords

  • Mechanical ventilation
  • Mortality
  • Prognosis
  • Survival


Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Child
  • Child, Preschool
  • Cystatin C
  • Disease Progression
  • Female
  • Heart Diseases
  • Heart Function Tests
  • Humans
  • Kidney Diseases
  • Kidney Function Tests
  • Male
  • Muscular Dystrophy, Duchenne
  • Risk Factors
  • Young Adult

Keywords

  • Duchenne muscular dystrophy
  • advanced stage
  • cystatin C
  • ejection fraction
  • fractional shortening
  • renal dysfunction

DNAJB9[править]

DNAJB9 Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation.


Keywords

  • DNAJB9
  • RAS
  • p53
  • senescence
  • transformation

DNMT1[править]

DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.


Keywords

  • DNA methylation
  • GABA
  • aging
  • cerebral cortex
  • inhibitory interneurons
  • proteostasis
  • synapse
  • transcriptional control

DNMT3A[править]

Epigenetic regulation of miR-29a/miR-30c/DNMT3A axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells.


Keywords

  • Cellular senescence
  • DNMT3A
  • Human mesenchymal stem cells
  • Mitochondrial oxidative stress
  • SOD2
  • microRNAs


Collagens and DNA methyltransferases in mare endometrosis.


MeSH Terms

  • Aging
  • Animals
  • Collagen
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methylation
  • Endometritis
  • Endometrium
  • Female
  • Fibrosis
  • Horse Diseases
  • Horses
  • RNA, Messenger

Keywords

  • DNA methylation
  • collagen
  • endometrium
  • epigenetic
  • fibrosis
  • mare


Age-related clonal haemopoiesis is associated with increased epigenetic age.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Epigenesis, Genetic
  • Female
  • Hematopoiesis
  • Humans
  • Longitudinal Studies
  • Male
  • Risk Factors
  • Scotland

DNMT3L[править]

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast.


Keywords

  • DNA methyltransferase 3-like (DNMT3L)
  • chromatin surveillance
  • epigenetics
  • polycomb repressive complex 2 (PRC2)
  • senescence
  • transposable element (TE)

DOCK11[править]

[Immunosenescence: The Forefront of Infection and Trophic Control].


MeSH Terms

  • Aging
  • Animals
  • B-Lymphocytes
  • Cytokinesis
  • Gene Expression
  • Guanine Nucleotide Exchange Factors
  • Humans
  • Immunoglobulin M
  • Immunosenescence
  • Mice
  • Nutritional Status
  • Streptococcus pneumoniae

Keywords

  • B-1a B cell
  • dedicator of cytokinesis 11
  • immunosenescence

DPP4[править]

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.


Keywords

  • DNA damage
  • aging
  • cellular senescence
  • chronic obstructive pulmonary diseases
  • idiopathic pulmonary fibrosis
  • mitochondria
  • smokers
  • telomere


Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway.


Keywords

  • Aging
  • Dipeptidyl peptidase-4
  • Endothelium
  • Oxidative stress
  • Vascular


Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.


Keywords

  • Aging
  • Cancer
  • Hepatology

DPP6[править]

A novel structure associated with aging is augmented in the DPP6-KO mouse brain.


Keywords

  • Aging dementia
  • Alzheimer’s disease
  • DPP6
  • Presynaptic terminals

DPYSL2[править]

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.


MeSH Terms

  • Alcohol Drinking
  • Alzheimer Disease
  • Amyloid beta-Protein Precursor
  • Animals
  • Behavior, Animal
  • Brain
  • Disease Models, Animal
  • Mice, Transgenic
  • tau Proteins

Keywords

  • Aging
  • Amyloid beta
  • Ethanol
  • GSK
  • Immunohistochemistry
  • Morris Water Maze
  • Prepulse inhibition
  • Self-administration
  • Tau pathology
  • Transgenic mouse model

DRD1[править]

Impact of dopamine-related genetic variants on physical activity in old age - a cohort study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Exercise
  • Humans
  • Receptors, Dopamine
  • Sedentary Behavior
  • Sweden

Keywords

  • Accelerometery
  • Aging
  • Dopamine
  • Genes
  • Physical activity
  • Sedentary behaviour

DRD2[править]

Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.


Keywords

  • Aging
  • Cortical thickness
  • DRD2
  • Dopamine
  • Executive function


The relationship of age and DRD2 polymorphisms to frontostriatal brain activity and working memory performance.


MeSH Terms

  • Aging
  • Brain
  • Humans
  • Memory, Short-Term
  • Polymorphism, Genetic
  • Receptors, Dopamine D2

Keywords

  • Aging
  • C957T
  • DRD2
  • Dopamine
  • Working memory
  • fMRI

DSPP[править]

Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells.


Keywords

  • aged teeth
  • apoptosis
  • dental pulp stem cells
  • differentiation
  • pulp regeneration
  • senescence

DST[править]

Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages.


MeSH Terms

  • Aging
  • Animals
  • Biological Evolution
  • DNA Replication
  • Humans
  • Phylogeny

Keywords

  • Aging
  • Asymmetric cell division
  • DNA replication
  • Disposable Soma Theory
  • Epigenetics
  • Evolution
  • Germen/Soma
  • Prokaryotes
  • Protists
  • Rejuvenation
  • Unicellular

DUSP1[править]

miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.


Keywords

  • aging
  • cardiac fibrosis
  • dual-specificity phosphatases
  • extracellular matrix
  • miR-1468-3p
  • microRNA
  • p38
  • senescence

DUSP8[править]

MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats.


MeSH Terms

  • Aging
  • Animals
  • Antagomirs
  • Anti-Inflammatory Agents
  • Cells, Cultured
  • Cerebral Hemorrhage
  • Dual-Specificity Phosphatases
  • HEK293 Cells
  • Heme Oxygenase-1
  • Hemin
  • Humans
  • Male
  • MicroRNAs
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction

Keywords

  • aging
  • dual-specificity phosphatase 8
  • haem oxygenase-1
  • intracerebral haemorrhage
  • microRNA

DUT[править]

Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis DUT1805.


Keywords

  • Aging paddy rice with hull (APRH)
  • Corn steep liquor powder (CSLP)
  • High-thermotolerance
  • Lactic acid
  • Saccharification and fermentation (SLSF)
  • Simultaneous liquification

DYRK1A[править]

Altered age-linked regulation of plasma DYRK1A in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load.


Keywords

  • Alzheimer's disease
  • aging
  • blood marker
  • immunometric test

E2F1[править]

Regulation of E2F1 activity via PKA-mediated phosphorylations.


Keywords

  • E2F1
  • PKA
  • cell cycle
  • forskolin
  • proliferation
  • senescence


Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.


Keywords

  • cell signal pathway
  • nerve cells
  • radiation
  • senescence

ECD[править]

Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Count
  • Cornea
  • Descemet Stripping Endothelial Keratoplasty
  • Donor Selection
  • Endothelium, Corneal
  • Female
  • Fuchs' Endothelial Dystrophy
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tissue Donors
  • Treatment Outcome
  • Visual Acuity
  • Young Adult

EDA[править]

Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression.


Keywords

  • Lung cancer
  • aging
  • fibronectin EDA
  • fibrosis
  • inflammation
  • lewis lung carcinoma
  • metastasis


Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli.


Keywords

  • aging adults
  • arousal
  • electrodermal activity
  • musical genres


The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments.


MeSH Terms

  • Adsorption
  • Agriculture
  • Ecosystem
  • Environmental Pollutants
  • Hydrogen Peroxide
  • Microplastics
  • Models, Chemical
  • Naphthalenes
  • Organic Chemicals
  • Phenanthrenes
  • Plastics
  • Polycyclic Aromatic Hydrocarbons
  • Polyethylene
  • Polypropylenes
  • Polyurethanes
  • Polyuria
  • Pyrenes
  • Salinity

Keywords

  • Aging
  • Microplastics
  • Polycyclic aromatic hydrocarbons
  • Salinity
  • Sorption

EDARADD[править]

Age prediction in living: Forensic epigenetic age estimation based on blood samples.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Child
  • Child, Preschool
  • CpG Islands
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • DNA Methylation
  • Edar-Associated Death Domain Protein
  • Fatty Acid Elongases
  • Female
  • Forensic Genetics
  • Humans
  • Infant
  • LIM-Homeodomain Proteins
  • Male
  • Middle Aged
  • Muscle Proteins
  • Polymerase Chain Reaction
  • Transcription Factors
  • Young Adult

Keywords

  • Age the living
  • CpGs
  • DNA methylation age
  • Forensic epigenetics
  • Forensic sciences

EDF1[править]

Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission.


Keywords 

         FOREVER YOUNG FLOWER
       

         Phalaenopsis orchids
  • Abscission
  • Ethylene responses
  • MADS-box gene
  • Senescence

EFS[править]

The aging bladder phenotype is not the direct consequence of bladder aging.


MeSH Terms

  • Adrenergic beta-Agonists
  • Aging
  • Animals
  • Carbachol
  • Cholinergic Agonists
  • Electric Stimulation
  • Female
  • Isoproterenol
  • Male
  • Mice
  • Mucous Membrane
  • Muscle Contraction
  • Myography
  • Phenotype
  • Receptor, Muscarinic M3
  • Receptors, Adrenergic, beta-2
  • Urinary Bladder
  • Urination

Keywords

  • aging
  • control physiology
  • resilience
  • urinary dysfunction

EGF[править]

Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging.


Keywords

  • growth factors
  • human aging
  • inflammation
  • physical activity


Proinflammation, profibrosis, and arterial aging.


Keywords

  • aging
  • artery
  • collagen
  • profibrosis
  • proinflammation
  • stiffening


Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma.


Keywords

  • Autophagy
  • Epidermal growth factor
  • Hinokitiol
  • Senescence
  • c-Jun N-Terminal kinase


Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines.


Keywords

  • EGFR
  • HUVEC
  • IMR90
  • Ras signaling
  • pro-inflammatory cytokine
  • senescence


Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i].


Keywords

  • ISC
  • fruit fly
  • insulin signaling pathway
  • lifespan
  • metabolism
  • midgut
  • progenitor cells


Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging.


MeSH Terms

  • Animals
  • ErbB Receptors
  • Signal Transduction
  • Swine

Keywords

  • Aging
  • Cell behaviour
  • EGF
  • EGFR
  • Signalling pathway

EGFR[править]

Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model.


Keywords

  • EGFR
  • Erlotinib
  • Type I collagen
  • aging
  • resistance


Comparative effectiveness and cost-effectiveness of three first-line EGFR-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan.


MeSH Terms

  • Afatinib
  • Aged
  • Carcinoma, Non-Small-Cell Lung
  • Cost-Benefit Analysis
  • Erlotinib Hydrochloride
  • Female
  • Gefitinib
  • Humans
  • Life Expectancy
  • Lung Neoplasms
  • Male
  • Propensity Score
  • Protein Kinase Inhibitors
  • Quality of Life
  • Survival Rate
  • Taiwan
  • Tertiary Care Centers


An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis.


MeSH Terms

  • Animals
  • Cell Communication
  • Cell Proliferation
  • Cells, Cultured
  • Drosophila Proteins
  • Drosophila melanogaster
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Homeostasis
  • Intestinal Mucosa
  • Light
  • Longevity
  • Optogenetics
  • Signal Transduction
  • Stem Cells

Keywords

  • Drosophila
  • EGFR
  • Toll
  • optogenetics
  • stem cells


Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cellular Senescence
  • Drug Resistance, Neoplasm
  • ErbB Receptors
  • Female
  • Gene Deletion
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms
  • MAP Kinase Kinase 1
  • Male
  • Mice
  • Mice, Knockout
  • Mutation
  • Signal Transduction
  • Transcription Factors
  • Transcription, Genetic

Keywords

  • YAP
  • dormancy
  • drug resistance
  • drug tolerance
  • epidermal growth factor receptor
  • lung cancer
  • senescence


Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Case-Control Studies
  • ErbB Receptors
  • Female
  • Gastroesophageal Reflux
  • Humans
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Mutation
  • Pneumonia
  • Republic of Korea
  • Retrospective Studies
  • Risk Factors
  • Young Adult

Keywords

  • Ageing
  • EGFR mutation
  • GERD
  • Lung cancer
  • Pneumonia
  • Risk factors

EHF[править]

Extended high frequency hearing and speech perception implications in adults and children.


Keywords

  • Aging
  • Development
  • Extended high frequency audiometry
  • Otitis media
  • Ototoxicity
  • Speech in noise
  • Speech perception
  • Tinnitus

EIF4E[править]

Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.


MeSH Terms

  • Aging
  • Animals
  • Insulin
  • Isoptera
  • Molecular Sequence Annotation
  • Signal Transduction
  • Transcriptome

ELF3[править]

High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i].


Keywords

  • Arabidopsis
  • PIF4
  • phytochrome
  • senescence
  • temperature

ELOVL2[править]

ELOVL2: Not just a biomarker of aging.


Keywords

  • Aging
  • Macular degeneration
  • Membrane structure
  • Polyunsaturated fatty acids


The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • DNA Methylation
  • Decitabine
  • Down-Regulation
  • Fatty Acid Elongases
  • Fatty Acids, Unsaturated
  • Female
  • Humans
  • Macular Degeneration
  • Male
  • Mice
  • Mice, Transgenic
  • Point Mutation
  • Promoter Regions, Genetic
  • Retina
  • Retinal Pigment Epithelium

Keywords

  • DNA methylation
  • ELOVL2
  • PUFA
  • age-related macular degeneration
  • aging
  • retina

EN1[править]

Electrochemically detecting DNA methylation in the EN1 gene promoter: implications for understanding ageing and disease.


Keywords

  • Aging
  • biosensor
  • electrochemistry
  • methylation

ENO1[править]

Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells.


Keywords

  • ENO1
  • Enolase
  • beta-Gal
  • cisplatin resistance
  • glucose
  • ovarian cancer
  • p21
  • p53
  • senescence

ENTPD7[править]

Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7).


MeSH Terms

  • Adult
  • Aged
  • Animals
  • Apoptosis
  • Apyrase
  • Biomarkers
  • Cell Line, Tumor
  • Cell Proliferation
  • Cells, Cultured
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Humans
  • Lung Neoplasms
  • MAP Kinase Signaling System
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Middle Aged
  • Mitogen-Activated Protein Kinases
  • Plasmids
  • Signal Transduction
  • Survival Analysis
  • raf Kinases
  • ras Proteins

Keywords

  • Ectonucleoside triphosphate phosphohydrolase-7
  • Lung cancer
  • Proliferation
  • Senescence

EPO[править]

Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.


Keywords

  • Aging
  • Brain
  • Erythropoietin
  • Glucose tolerance
  • Hypothalamus
  • Metabolism
  • Muscle
  • Obesity


Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease.


MeSH Terms

  • Anemia
  • Erythrocytes
  • Female
  • Humans
  • Male
  • Middle Aged
  • Renal Insufficiency, Chronic

Keywords

  • Chronic kidney disease
  • Erythropoietin
  • Levitt’s CO breath test
  • Red blood cell lifespan
  • Renal anemia

ERCC1[править]

Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.


Keywords

  • aging
  • cGMP
  • guanylate cyclase
  • hypertension
  • nitric oxide
  • phosphodiesterase
  • sildenafil
  • vascular dysfunction


Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Capillary Permeability
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Endonucleases
  • Endothelial Cells
  • Endothelium, Vascular
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Superoxides
  • Vascular Stiffness
  • Vasodilation

Keywords

  • DNA damage
  • aging
  • endothelial dysfunction
  • endothelium-dependent dilation
  • nitric oxide


Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice.


Keywords

  • DNA repair
  • ERCC1-XPF
  • aging
  • cellular senescence
  • endogenous DNA damage
  • progeria


Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.


Keywords

  • DNA damage repair
  • aging
  • cell death
  • senescence-associated secretory phenotype
  • tumor necrosis factor α

ERF[править]

Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women.


Keywords

  • ACE D/I gene polymorphism
  • Chinese women
  • aging
  • endothelial function
  • endothelial-released factors
  • menopause


Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review.


Keywords

  • Air pollution
  • Climate change
  • Mortality
  • Population aging
  • Projection
  • Temperature


Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length.


Keywords

  • ATM
  • RPL8
  • aging
  • meta-analysis
  • telomere
  • whole exome sequencing

ERG[править]

Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat.


Keywords

  • Aging
  • Electroretinography
  • Neurodegeneration
  • Neurodevelopment
  • Optical coherence tomography
  • Retina
  • Sex


Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging.


MeSH Terms

  • Aging
  • Animals
  • Biomarkers
  • Electroretinography
  • Enzyme-Linked Immunosorbent Assay
  • Immunohistochemistry
  • Malondialdehyde
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Mitochondria
  • Oxidative Stress
  • Protein Deglycase DJ-1
  • Retina
  • Retinal Degeneration
  • Retinal Pigment Epithelium
  • Superoxide Dismutase-1
  • Tomography, Optical Coherence
  • Ubiquitin-Protein Ligases

ESPL1[править]

Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.


Keywords

  • Genomics
  • Longevity
  • Pedigree
  • Rare variant sharing
  • Utah population database

ETS1[править]

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1.


MeSH Terms

  • ATP Binding Cassette Transporter, Subfamily B
  • Animals
  • Apoptosis
  • Cellular Senescence
  • Hepatocytes
  • Humans
  • Lipopolysaccharides
  • Liver
  • Mice
  • Proto-Oncogene Protein c-ets-1
  • Transcription Factors
  • bcl-X Protein

Keywords

  • BCL2 like 1 (BCL2L1)
  • apoptosis
  • cholangiocyte
  • chromatin modification
  • epigenetics
  • gene expression
  • primary sclerosing cholangitis (PSC)
  • senescence
  • transcription factor

EVL[править]

Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis.


MeSH Terms

  • Cost-Benefit Analysis
  • Health Care Costs
  • Health Status
  • Health Status Indicators
  • Humans
  • Life Expectancy
  • Quality of Life
  • Quality-Adjusted Life Years
  • Time Factors

Keywords

  • cost-effectiveness
  • equal value of life
  • health years in total
  • quality-adjusted life-year
  • thresholds

EZH2[править]

Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus).


Keywords

  • Cetacea
  • aging
  • bone
  • hyperostosis
  • osteoblasts
  • whales


EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice.


Keywords

  • Aging
  • CUMS
  • Cytokines
  • Depresion
  • EZH2
  • Microglia


A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration.


Keywords

  • Epigenetic histone modification
  • Intervertebral disc degeneration
  • Nucleus pulposus cell senescence
  • Wnt/β-catenin signaling pathway


Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils.


MeSH Terms

  • Actins
  • Aging
  • Animals
  • Benzhydryl Compounds
  • Cell Proliferation
  • Collagen
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Gerbillinae
  • Histones
  • Mammary Glands, Animal
  • Phenols
  • Pregnancy
  • Prenatal Exposure Delayed Effects

Keywords

  • BPA
  • EZH2
  • Environment pollutant
  • Estrogen
  • Morphologic alterations
  • Phospho-histone-h3

F2[править]

Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin.


Keywords

  • Glufosinate resistance
  • Relative fitness
  • Seed longevity
  • Transgene flow
  • Weed risk


Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways.


Keywords

  • Arsenic
  • Liver
  • Multigenerational Effect
  • SASP
  • Senescence
  • Tumor


Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone.


Keywords

  • Thyroid
  • longevity
  • recombinant human TSH
  • responsivity


Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan.


MeSH Terms

  • Adiposity
  • Aging
  • Animals
  • Exploratory Behavior
  • Female
  • Male
  • Memory
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Swimming

Keywords

  • F2 hybrid mice
  • aging
  • exploratory activity
  • sex comparison
  • water-based behavioral tests


In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.


MeSH Terms

  • Acetaminophen
  • Aging
  • Animals
  • Animals, Newborn
  • Cell Proliferation
  • Female
  • Fertility
  • Forkhead Box Protein O3
  • Germ Cells
  • Ibuprofen
  • Luteolysis
  • Mice
  • Ovary
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Proto-Oncogene Proteins c-akt
  • Reproduction
  • Signal Transduction

Keywords

  • Infertility
  • Oogenesis
  • Risk factors

F3[править]

A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels.


Keywords

  • Acoustic
  • Aging voice
  • European Portuguese
  • Oral vowel


Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.


Keywords

  • cyclicity
  • hormone
  • mixture
  • ovary
  • phthalates
  • reproductive aging
  • transgenerational


Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.


Keywords

  • Aging
  • cognition
  • rehabilitation
  • transcranial direct current stimulation
  • walking


Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Insulin
  • Longevity
  • Nanoparticles
  • Oxidative Stress
  • Soil
  • Titanium

Keywords

  • Insulin/IGF-like signaling
  • Longevity
  • Multigenerational toxicity
  • Nanomaterial
  • Soil nematode


Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.


MeSH Terms

  • Aging
  • Animals
  • Fatty Acids, Nonesterified
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Lipid Metabolism
  • Mice
  • Microarray Analysis
  • Signal Transduction
  • Triglycerides
  • Vascular Diseases

Keywords

  • aging
  • co-expression network
  • hub gene
  • module
  • mouse
  • vascular dysfunction

F5[править]

Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.


Keywords

  • ALP, alkaline phosphatase
  • ALT, alanine aminotransferase
  • Aging
  • BMI, body mass index
  • DNAm, DNA methylation
  • ELF, enhanced liver fibrosis
  • FDR, false discovery rate
  • GGT, gamma-glutamyltransferase
  • IBD, inflammatory bowel disease
  • IL, interleukin
  • LOXL2, lysyl oxidase-like-2
  • NASH, non-alcoholic steatohepatitis
  • PSC, primary sclerosing cholangitis
  • SMA, smooth muscle actin
  • UDCA, ursodeoxycholic acid
  • biomarker
  • inflammatory bowel disease
  • primary sclerosing cholangitis
  • prognosis
  • ursodeoxycholic acid


Fermentation of Blackberry with [i]L. plantarum[/i] JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Survival
  • Female
  • Fermentation
  • Fibroblasts
  • Foreskin
  • Fruit
  • Lactobacillus plantarum
  • Male
  • Mice
  • Mice, Hairless
  • Plant Extracts
  • Rubus
  • Skin Aging
  • Ultraviolet Rays

Keywords

  • Lactobacillus plantarum
  • MMPs
  • fermented blackberry
  • photoaging
  • skin aging
  • type I procollagen

F7[править]

The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls.


MeSH Terms

  • Aged
  • Aging
  • Cognitive Dysfunction
  • Electroencephalography
  • Emotions
  • Female
  • Frontal Lobe
  • Humans
  • Male
  • Memory
  • Neurophysiological Monitoring
  • Neuropsychological Tests
  • Task Performance and Analysis
  • Temporal Lobe

Keywords

  • Emotional destination memory
  • Mu suppression
  • fronto-temporal
  • mild cognitive impairment
  • mirror neurons

FAAH[править]

Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.


MeSH Terms

  • Aging
  • Amidohydrolases
  • Animals
  • Axons
  • Choice Behavior
  • Dronabinol
  • Endocannabinoids
  • Female
  • Genetic Variation
  • Male
  • Mice, Inbred C57BL
  • Nerve Net
  • Nucleus Accumbens
  • Polymorphism, Single Nucleotide
  • Receptor, Cannabinoid, CB1
  • Reward
  • Tyrosine 3-Monooxygenase
  • Ventral Tegmental Area

FABP3[править]

FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging.


MeSH Terms

  • Aging
  • Animals
  • Cell Line
  • Endoplasmic Reticulum Stress
  • Eukaryotic Initiation Factor-2
  • Fatty Acid Binding Protein 3
  • Female
  • Gene Knockdown Techniques
  • Lipidomics
  • Membrane Fluidity
  • Membrane Lipids
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Skeletal
  • Myoblasts
  • Phospholipids
  • Protein-Serine-Threonine Kinases
  • Sarcopenia
  • Up-Regulation


Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.


Keywords

  • Adipogenesis
  • autophagy
  • bone metabolism
  • fabp3
  • mesenchymal stem cell
  • optineurin
  • osteogenesis
  • osteoporosis
  • senescence


Myokines as biomarkers of frailty and cardiovascular disease risk in females.


Keywords

  • Aging
  • Biomarkers
  • Cardiovascular disease
  • Females
  • Frailty
  • Myokines

FADS1[править]

Aging and FADS1 polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Alleles
  • Arachidonic Acid
  • Area Under Curve
  • Fatty Acid Desaturases
  • Fatty Acids, Unsaturated
  • Female
  • Healthy Volunteers
  • Humans
  • Linoleic Acid
  • Male
  • Polymorphism, Single Nucleotide

Keywords

  • Aging
  • Arachidonic acid
  • Fatty acid conversion
  • Linoleic acid
  • Lipid metabolism
  • Long-chain polyunsaturated fatty acid

FANCD2[править]

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response.


Keywords

  • DNA damage response
  • FANCD2
  • TFG
  • aging and cancer

FAP[править]

Rapamycin Extends Life Span in Apc Colon Cancer FAP Model.


Keywords

  • Aging
  • Crypt stem cells
  • eEF2K
  • mTORC1
  • rpS6


Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Exercise Therapy
  • Female
  • Humans
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Muscular Diseases
  • Regeneration


Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy.


MeSH Terms

  • Adipogenesis
  • Adolescent
  • Adult
  • Adult Stem Cells
  • Aged
  • Aging
  • Cells, Cultured
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Muscle Development
  • Muscular Dystrophy, Duchenne
  • Myoblasts
  • Young Adult

Keywords Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies

FAS[править]

Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults.


Keywords

  • Aging
  • Biological age
  • Elderly
  • Physical function
  • Tongue pressure


Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity.


Keywords

  • MDM2
  • Senescence
  • USP7
  • apoptosis
  • p53
  • senolytics

FES[править]

An outpatient Tai Chi program: Effects on veterans' functional outcomes.


Keywords

  • Tai Chi
  • balance
  • exercise
  • gait
  • geriatrics


Gait Function in Adults Aged 50 Years and Older With Spina Bifida.


Keywords

  • Adult
  • Aging
  • Gait analysis
  • Myelomeningocele
  • Rehabilitation


A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons.


Keywords

  • FES-I
  • elderly
  • fear of falling
  • healthy aging
  • older adults


Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study.


MeSH Terms

  • Accidental Falls
  • Activities of Daily Living
  • Aged
  • Aging
  • Female
  • Geriatric Assessment
  • Humans
  • Independent Living
  • Japan
  • Longitudinal Studies
  • Male
  • Physical Functional Performance
  • Postural Balance
  • Risk Factors
  • Walking Speed

Keywords

  • Accidental falls
  • Aged
  • Fall-related efficacy
  • Japanese
  • Physical performance


Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence.


MeSH Terms

  • Accidental Falls
  • Aged
  • Aging
  • Brain
  • Electroencephalography
  • Fear
  • Female
  • Humans
  • Male
  • Movement
  • Postural Balance
  • Posture

FEV[править]

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach.


Keywords

  • epigenetic aging
  • feature selection
  • hyperparameter tuning
  • lung function
  • machine learning


Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.


Keywords

  • COPD
  • aging
  • exacerbations
  • safety
  • single-inhaler triple therapy


A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging.


Keywords

  • Aging
  • Determinants
  • Lung function
  • Sex
  • Spirometry


Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects.


Keywords

  • Aging
  • COPD
  • Klotho
  • Pulmonary emphysema
  • Risk factors
  • Telomere length


Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age.


Keywords

  • Aging
  • Asthma
  • Long-acting muscarinic antagonist
  • Long-acting β(2)-agonists
  • Pharmacotherapy


Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults.


Keywords

  • aging
  • albuterol
  • asthma
  • bronchodilator effect
  • lung diseases
  • older adult
  • spirometry


Physical performances show conflicting associations in aged manual workers.


MeSH Terms

  • Aged
  • Aging
  • Body Composition
  • Body Mass Index
  • Cardiorespiratory Fitness
  • Cross-Sectional Studies
  • Hand Strength
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Physical Functional Performance


FEV as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons.


Keywords

  • aging
  • average attributable fraction
  • death
  • relative risk
  • spirometry


An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population.


MeSH Terms

  • Adult
  • Age Factors
  • Aging
  • Alcohol Drinking
  • Algorithms
  • Alkaline Phosphatase
  • Body Height
  • Bronchodilator Agents
  • Cigarette Smoking
  • Cohort Studies
  • Cough
  • Dyspnea
  • Electrocardiography
  • Female
  • Forced Expiratory Volume
  • Hematocrit
  • Humans
  • Leukocyte Count
  • Longitudinal Studies
  • Lung
  • Machine Learning
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive
  • Risk Assessment
  • Serum Albumin
  • Serum Globulins
  • Sex Factors
  • Spirometry
  • Triglycerides
  • Vital Capacity

Keywords

  • COPD
  • FEV(1)
  • FEV(1)/FVC
  • airflow limitation
  • lung function
  • predictive modeling


Telomere length and lung function in a population-based cohort of children and mid-life adults.


MeSH Terms

  • Aged
  • Asthma
  • Body Mass Index
  • Child
  • Cohort Studies
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung
  • Male
  • Respiratory Function Tests
  • Risk Factors
  • Smoking
  • Spirometry
  • Telomere
  • Vital Capacity

Keywords

  • aging
  • cell senescence
  • life course
  • national cohort
  • spirometry

FGA[править]

Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability.


MeSH Terms

  • Adaptation, Psychological
  • Aged
  • Aging
  • Depression
  • Disabled Persons
  • Female
  • Goals
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Muscular Dystrophies
  • Pain
  • Postpoliomyelitis Syndrome
  • Spinal Cord Injuries

Keywords

  • aging
  • disability
  • goal management
  • pain
  • psychological adaptation


Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples.


Keywords

  • flexible goal adjustment
  • life satisfaction
  • older couples
  • self-perceptions of aging
  • tenacious goal pursuit

FGF19[править]

Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation.


Keywords

  • FGF19
  • FXR
  • TGR5
  • autoimmunity
  • senescence

FGF2[править]

The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture.


Keywords

  • cell proliferation
  • cellular senescence
  • fibroblast growth factor 2
  • long-term culture
  • mesenchymal stem cell

FGF21[править]

Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice.


Keywords

  • Clostridales
  • firmicutes
  • lifespan
  • methionine restriction
  • sulfur metabolism


Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults.


Keywords

  • Accelerometer
  • Activity intensity
  • Aging
  • FGF21
  • Physical activity


Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.


Keywords

  • Aging
  • Exercise
  • FGF21
  • Lipophagy
  • Nonalcoholic fatty liver disease (NAFLD)


Mitochondria, immunosenescence and inflammaging: a role for mitokines?


Keywords

  • Human ageing
  • Immunosenescence
  • Inflammaging
  • Mitochondrial metabolism
  • Mitokines


Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats.


Keywords

  • ER stress
  • cysteine
  • glutathione
  • hormesis
  • lifespan
  • methionine
  • trade-offs
  • translational


Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i].


Keywords

  • Bombyx mori
  • fibroblast growth factor 21 (FGF21)
  • lifespan
  • oxidation resistance
  • stress tolerance


Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice.


MeSH Terms

  • Animals
  • Butyrates
  • Fecal Microbiota Transplantation
  • Fibroblast Growth Factors
  • Gastrointestinal Microbiome
  • Germ-Free Life
  • Hippocampus
  • Intestines
  • Liver
  • Longevity
  • Male
  • Metabolome
  • Mice, Inbred C57BL
  • Microtubule-Associated Proteins
  • Neurogenesis
  • Neurons
  • Neuropeptides
  • Phenotype
  • Proton Magnetic Resonance Spectroscopy


Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation.


MeSH Terms

  • Adiponectin
  • Adult
  • Aging
  • Blood Glucose
  • Blood Pressure
  • Body Mass Index
  • Diabetes Mellitus, Type 2
  • Exercise
  • Female
  • Fibroblast Growth Factors
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Lipids
  • Male
  • Middle Aged
  • Risk Factors


Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing.


MeSH Terms

  • Adiposity
  • Aging
  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Blood Glucose
  • Diet, Fat-Restricted
  • Dietary Fats
  • Disease Models, Animal
  • Dyslipidemias
  • Glucagon
  • Insulin
  • Lipids
  • Liver
  • Metabolic Syndrome
  • Postprandial Period
  • Rats
  • Rats, Wistar
  • Triglycerides

Keywords

  • ChREBP
  • adipose tissue
  • ageing
  • oral lipid loading test
  • postprandial hypertrigliceridemia
  • postprandial thermogenesis

FGF23[править]

Phosphate as a Pathogen of Arteriosclerosis and Aging.


Keywords

  • Aging
  • Calciprotein particles (CPPs)
  • Fibroblast growth factor-23 (FGF23)
  • Inflammation
  • Klotho
  • Phosphate
  • Vascular calcification


Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults.


Keywords

  • aging
  • chronic kidney disease
  • fibroblast growth factor 23
  • mobility disability
  • αKlotho


Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.


MeSH Terms

  • Aging
  • Animals
  • Calcium
  • Dietary Carbohydrates
  • Fibroblast Growth Factors
  • Galactose
  • Glucuronidase
  • Male
  • Oxidative Stress
  • Phosphorus
  • Phytochemicals
  • Polygonatum
  • Polysaccharides
  • Protective Agents
  • Rats
  • Rats, Sprague-Dawley


FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model.


MeSH Terms

  • Aldosterone
  • Animals
  • Bone and Bones
  • Cardiovascular Diseases
  • Disease Models, Animal
  • Female
  • Fibroblast Growth Factors
  • Gene Knockout Techniques
  • Glucuronidase
  • Kidney
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Osteoblasts
  • Protein Isoforms
  • Transcriptome

Keywords

  • Bone Biology
  • Cardiovascular disease


Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats.


MeSH Terms

  • Aging
  • Animals
  • Arginine
  • Biomarkers
  • Cats
  • Cross-Sectional Studies
  • Female
  • Fibroblast Growth Factors
  • Male
  • Reference Values
  • Retrospective Moral Judgment

Keywords

  • azotemia
  • feline
  • phosphate
  • renal

FGFR1[править]

Alignment of Alzheimer's disease amyloid β-peptide and klotho.


Keywords

  • Alzheimer’s disease
  • HSV-1
  • aging
  • alignment
  • klotho
  • neurodegeneration
  • neuroinflammation
  • protein
  • ubiquitin
  • β-amyloid


Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration.


Keywords

  • Cdon
  • Cellular senescence
  • FGFR
  • Growth factor signalling
  • Muscle regeneration
  • Satellite cell

FGFR4[править]

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.


Keywords

  • FGFR4
  • FGFR4 inhibitor
  • growth
  • invasion
  • pancreatic cancer
  • senescence
  • senolytic therapy

FGR[править]

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.


Keywords

  • Aurora kinase
  • Cellular senescence
  • FGR
  • Preeclampsia

FH[править]

Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.


Keywords

  • APOE4
  • Aging
  • Mediterranean diet
  • cognitive decline
  • functional food
  • lamb
  • nutrition policy
  • preventive medicine
  • red wine
  • salt


Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia.


MeSH Terms

  • Adult
  • Aging
  • Alzheimer Disease
  • Apolipoproteins E
  • Atrophy
  • Dementia
  • Diffusion Magnetic Resonance Imaging
  • Educational Status
  • Female
  • Genotype
  • Hippocampus
  • Humans
  • Male
  • Middle Aged
  • Organ Size
  • Risk

Keywords

  • Alzheimer's disease
  • Dementia
  • Hippocampal subfields
  • Hippocampus
  • Preclinical dementia


Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cross-Sectional Studies
  • Female
  • Hematuria
  • Hemophilia A
  • Humans
  • Hypertension
  • Israel
  • Logistic Models
  • Male
  • Middle Aged
  • Risk Factors


LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis.


MeSH Terms

  • Aging
  • Amyloid beta-Protein Precursor
  • Animals
  • Apoptosis
  • Brain Chemistry
  • Caspase 3
  • Cholesterol
  • Gene Expression
  • Hippocampus
  • Male
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Prefrontal Cortex
  • Receptors, LDL

Keywords

  • Familial hypercholesterolemia
  • LDLr-/- mice
  • amyloid-β
  • apoptosis
  • memory impairment

FNDC5[править]

Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts.


Keywords

  • BONE-MUSCLE INTERACTIONS
  • IRISIN
  • OSTEOPOROSIS
  • SARCOPENIA
  • SENESCENCE


[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]


MeSH Terms

  • Aged
  • Aging
  • Biomarkers
  • Cytokines
  • Humans
  • Middle Aged
  • Myocardial Infarction
  • Saliva
  • Tumor Necrosis Factor-alpha

Keywords

  • aging
  • diagnosis
  • myocardial infarction
  • saliva
  • signaling molecules

FOS[править]

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs.


Keywords

  • HIF-1α-AS2
  • aging
  • lncRNAs
  • miR-29b-3p
  • muscle atrophy

FOSL2[править]

LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis.


Keywords

GUARDIN

  • LRP130-PGC1α
  • cellular senescence
  • lncRNAs
  • p21

FOXA1[править]

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer.


MeSH Terms

  • Breast Neoplasms
  • Down-Regulation
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Neoplastic
  • Hepatocyte Nuclear Factor 3-alpha
  • Humans
  • Middle Aged
  • Prognosis
  • RNA, Messenger
  • Receptor, ErbB-2
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Transcriptome
  • Up-Regulation

Keywords

  • FOXA1
  • age-related diseases
  • aging
  • breast cancer
  • hormone receptor
  • methylation
  • prognosis

FOXM1[править]

Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression.


Keywords

  • FOXM1
  • SIRT6
  • cell cycle
  • endothelial cell
  • senescence

FOXN1[править]

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation.


Keywords

  • Aging
  • Immunology
  • Immunotherapy
  • T cell development

FOXO1[править]

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.


Keywords

  • AGEs
  • Inflammatory response
  • Liver aging
  • Oxidative stress
  • l-Theanine

FOXO3[править]

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma.


Keywords

  • Aging
  • DNA methylation
  • FOXO3
  • Late-onset asthma
  • TP53


FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase.


Keywords

  • neurodegenerative disease
  • neuronal differentiation
  • neuronal senescence
  • response mechanisms
  • temporal dynamics


Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.


Keywords

  • FOXO3
  • NRF2
  • SIRT1
  • astaxanthin
  • geroprotector
  • longevity
  • neuroprotection


Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing.


Keywords

  • IL6
  • IL6R
  • aging
  • cachexia
  • miR-21
  • microRNA
  • muscle
  • regeneration
  • sarcopenia


Variable DNA methylation of aging-related genes is associated with male COPD.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Case-Control Studies
  • CpG Islands
  • DNA Methylation
  • Databases, Genetic
  • Female
  • Forced Expiratory Volume
  • Forkhead Transcription Factors
  • Genetic Predisposition to Disease
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Transcriptome
  • Vital Capacity
  • Young Adult

Keywords

  • Aging
  • Aging-related genes
  • COPD
  • DNA methylation


A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.


MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Cohort Studies
  • Disease Models, Animal
  • Drosophila melanogaster
  • Feeding Behavior
  • Female
  • Gene Knockdown Techniques
  • Gout
  • Humans
  • Insulin
  • Kidney Calculi
  • Longevity
  • Male
  • Metabolic Networks and Pathways
  • Middle Aged
  • NADPH Oxidases
  • Polymorphism, Single Nucleotide
  • Purines
  • Signal Transduction
  • Urate Oxidase
  • Uric Acid

FOXO4[править]

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.


Keywords

  • FOXO4-DRI
  • Leydig cell
  • male late-onset hypogonadism
  • senescence
  • senolytics

FOXP1[править]

GATA6 regulates aging of human mesenchymal stem/stromal cells.


Keywords

  • aging
  • cell signaling
  • mesenchymal stem cells
  • reprogramming
  • transcription factors

FSHR[править]

FSHR ablation induces depression-like behaviors.


Keywords

  • FSH
  • ROS
  • aging
  • antioxidants
  • depression
  • metabolism


Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka].


MeSH Terms

  • Aging
  • Female
  • Gonadotropin-Releasing Hormone
  • Gonadotropins
  • Humans
  • Hypothalamo-Hypophyseal System
  • Luteinizing Hormone
  • Male
  • Receptors, FSH
  • Receptors, LH

Keywords

  • aging
  • folitropin
  • lutropin
  • neoplasia

FTO[править]

Decreased expression of m A demethylase FTO in ovarian aging.


Keywords

  • Epigenetics
  • FTO
  • Ovarian aging
  • Ovarian reserve
  • m6A

FYN[править]

An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction.


MeSH Terms

  • Animals
  • Cardiomyopathies
  • Cellular Senescence
  • Echocardiography
  • Gene Silencing
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Infarction
  • Myocardium
  • Myocytes, Cardiac
  • NF-E2-Related Factor 2
  • RNA, Small Interfering
  • Ventricular Remodeling

Keywords

  • Cellular senescence
  • Myocardial infarction
  • Nrf2
  • Oxidative stress

G6PD[править]

G6PD overexpression protects from oxidative stress and age-related hearing loss.


Keywords

  • ARHL
  • NADPH
  • TrxR
  • aging
  • glutathione


The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability.


Keywords

  • diabetes
  • genetics
  • glycosylated hemoglobin
  • hba1c
  • hbas
  • race
  • rbc lifespan
  • sickle cell trait


DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice.


MeSH Terms

  • Animals
  • Brain
  • DNA Breaks, Double-Stranded
  • DNA Breaks, Single-Stranded
  • DNA Damage
  • Disease Models, Animal
  • Enzyme Activation
  • Female
  • Glucosephosphate Dehydrogenase
  • Glucosephosphate Dehydrogenase Deficiency
  • Male
  • Mental Disorders
  • Mice
  • Oxidation-Reduction
  • Purkinje Cells

Keywords

  • 8-Oxo-2′-deoxyguanine (8-oxodG)
  • Aging
  • Behavioural disorders
  • Comet
  • DNA damage
  • Electrophysiology
  • Gamma-H2AX (γH2AX)
  • Glucose-6-phosphate dehydrogenase (G6PD)
  • Lifespan
  • Neurodegeneration
  • Reactive oxygen species (ROS)

GAA[править]

Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.


Keywords

  • Frataxin
  • Friedreich's ataxia
  • Mitochondria
  • Oxidative stress
  • Point mutation
  • Senescence


Age-Related Changes in Serum Guanidinoacetic Acid in Women.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Biomarkers
  • Energy Metabolism
  • Exercise
  • Female
  • Glycine
  • Humans
  • Independent Living
  • Middle Aged
  • Young Adult

GABARAP[править]

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.


MeSH Terms

  • Adipocytes
  • Adipogenesis
  • Adipose Tissue
  • Adiposity
  • Aging
  • Animals
  • Apoptosis Regulatory Proteins
  • Autophagy
  • Fatty Liver
  • Gene Knockout Techniques
  • Glucose
  • HEK293 Cells
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Lipid Metabolism
  • Metabolic Diseases
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microtubule-Associated Proteins
  • Nuclear Receptor Coactivator 1
  • Nuclear Receptor Coactivator 2
  • PPAR gamma

GAL[править]

Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis.


Keywords

  • Osteoarthritis
  • Pitx1
  • Senescence
  • Sirt1


β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • DNA Damage
  • Disease Models, Animal
  • Galactose
  • Glial Fibrillary Acidic Protein
  • Hippocampus
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Neuroprotection
  • Oxidative Stress
  • Polycyclic Sesquiterpenes
  • Prefrontal Cortex

Keywords

  • CB2 receptor agonist
  • biological aging
  • cognitive flexibility
  • phytocannabinoid
  • β-caryophyllene

GAP43[править]

HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI.


MeSH Terms

  • Aging
  • Animals
  • Axons
  • GAP-43 Protein
  • Gene Deletion
  • Gene Expression
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Hydroxamic Acids
  • Mice, Transgenic
  • Motor Activity
  • Nerve Regeneration
  • PTEN Phosphohydrolase
  • Recovery of Function
  • Spinal Cord
  • Spinal Cord Injuries

Keywords

  • Aging
  • Epigenetics
  • Histone deacetylase
  • Pten
  • Regeneration
  • Spinal cord injury

GATA4[править]

Epigenetics and Vascular Senescence-Potential New Therapeutic Targets?


Keywords

  • calcification
  • cell senescence
  • epigenetics
  • inflammation
  • oxidation stress
  • vascular aging


Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype.


Keywords

  • IGFBP-5
  • Rho kinase inhibitor
  • Y-27632
  • dermal fibroblast
  • senescence

GBA[править]

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.


MeSH Terms

  • Aged
  • Aging
  • Female
  • Glucosylceramidase
  • Humans
  • Hydrolases
  • Lysosomes
  • Male
  • Mutation
  • Parkinson Disease
  • Risk Factors
  • Substantia Nigra
  • alpha-Synuclein

Keywords

  • Ageing
  • Ganglioside
  • Glucocerebrosidase
  • Glycosphingolipid
  • Lysosome
  • Neurodegeneration
  • Parkinson’s disease

GC[править]

Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae).


Keywords 

         Chrysomya albiceps
  • body size
  • cuticular hydrocarbon
  • forensic
  • larval longevity


Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan.


Keywords

  • Caenorhabditis elegans
  • Fatty acid
  • Flavonoid identification and composition
  • Lifespan extension
  • Tree peony petal


Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.


Keywords

  • Aging
  • Antioxidant
  • Food packaging materials
  • Microplastics
  • Polypropylene
  • seawater


Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells.


Keywords

  • AMP-activated kinase (AMPK)
  • Cell senescence
  • cell cycle
  • cellular senescence
  • galectin
  • galectin-3
  • glycoprotein
  • liver injury
  • proliferation
  • protein interaction
  • protein-protein interaction
  • quiescence
  • stem cells
  • stemness exhaustion


Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers.


Keywords

  • aging
  • cellulose insulation
  • gas chromatography
  • headspace sampling


Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes.


MeSH Terms

  • Fruit
  • Gas Chromatography-Mass Spectrometry
  • Hexanols
  • Norisoprenoids
  • Odorants
  • Olfactometry
  • Principal Component Analysis
  • Sulfhydryl Compounds
  • Vitis
  • Volatile Organic Compounds

Keywords

  • Aging
  • Aroma precursors
  • Glycosides
  • Lipid-derived aroma
  • Norisoprenoids
  • Sensory properties
  • Terpenols
  • Volatile phenols


Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline.


Keywords

  • Accelerated cognitive ageing
  • Ageing
  • Aging
  • Biomarkers
  • Clinical research
  • Cognition
  • Cognitive decline
  • Cognitive neuroscience
  • Effective connectivity
  • Epilepsy
  • Fmri
  • Granger causality
  • Image processing
  • Medical imaging
  • Mental health
  • Nervous system
  • Neuroscience
  • Psychiatry


Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry (GC-IMS).


Keywords

  • Aging
  • Electronic-nose
  • Gas chromatography-ion mobility spectrometry
  • Jinhua ham
  • Volatiles


Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry.


Keywords

  • Aging
  • C. elegans
  • Fat
  • Fatty acids
  • Gas chromatography–mass spectrometry
  • Lipids
  • Phospholipids
  • Solid-phase chromatography
  • Triglycerides


Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity.


MeSH Terms

  • Aging
  • Agrocybe
  • Antioxidants
  • Carbohydrate Sequence
  • Cell Line
  • Chemical Phenomena
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Membrane Potential, Mitochondrial
  • Mitochondria
  • Polysaccharides

Keywords

  • Agrocybe aegirita polysaccharide
  • Anti-ageing
  • Cell cycle
  • Mitochondrial membrane potential
  • Structure


Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Biphenyl Compounds
  • Carbohydrate Conformation
  • Galactans
  • Male
  • Mentha
  • Mice
  • Mice, Inbred Strains
  • Particle Size
  • Picrates
  • Surface Properties

Keywords

  • Anti-aging activity
  • Antioxidant activity
  • Mentha haplocalyx Briq
  • Polysaccharides


Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures.


Keywords

  • Cognac
  • aging aroma
  • lees
  • monoterpenes
  • perceptual synergic effects


Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.


MeSH Terms

  • Aging
  • Animals
  • Animals, Newborn
  • Female
  • Fetus
  • Formates
  • Liver
  • Maternal-Fetal Exchange
  • Mothers
  • Placenta
  • Pregnancy
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • fetus
  • glycine
  • methionine
  • mitochondria
  • one-carbon metabolism
  • pregnancy
  • serine
  • tetrahydrofolate


Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs).


Keywords

  • Aging
  • Glycosidic precursors
  • Grape aroma
  • Grape quality
  • Hydrolysis
  • Polyphenols
  • Wine


Compromised steady-state germinal center activity with age in nonhuman primates.


MeSH Terms

  • Aging
  • Animals
  • Antigens, CD
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Forkhead Transcription Factors
  • Germinal Center
  • Granulocytes
  • Immunity, Humoral
  • Inflammation
  • Lymph Nodes
  • Macaca mulatta
  • Monocytes

Keywords

  • B cells
  • Tfh cells
  • aging
  • follicles


Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues.


MeSH Terms

  • Adipose Tissue
  • Adiposity
  • Animals
  • Bone Marrow
  • Energy Metabolism
  • Glucocorticoids
  • Homeostasis
  • Humans
  • Liver
  • Muscle, Skeletal
  • Receptor Cross-Talk
  • Receptors, Glucocorticoid
  • Signal Transduction
  • Stress, Physiological

Keywords

  • Adipocyte
  • Aging
  • Bone marrow
  • Corticosterone
  • Cortisol
  • Cortisone
  • Glucocorticoid
  • Osteoblast


4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.


MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Cycle
  • Cell Proliferation
  • Cellular Senescence
  • DNA Damage
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Picolinic Acids
  • Signal Transduction
  • Stomach Neoplasms
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Keywords

  • Cellular senescence
  • DNA damage
  • Gastric cancer
  • N-heterocyclic compound


Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats.


MeSH Terms

  • Administration, Oral
  • Aging
  • Animals
  • Body Temperature
  • Cerebellum
  • Cyclopropanes
  • Dose-Response Relationship, Drug
  • Hydrocarbons, Fluorinated
  • Liver
  • Male
  • Pyrethrins
  • Rats
  • Rats, Wistar
  • Tissue Distribution
  • Toxicokinetics

Keywords

  • acute effects
  • bifenthrin
  • body temperature
  • disposition
  • rat
  • tefluthrin


Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly.


MeSH Terms

  • Aged
  • Beta vulgaris
  • Breath Tests
  • Dietary Supplements
  • Double-Blind Method
  • Exhalation
  • Fatty Acids, Volatile
  • Feces
  • Female
  • Gastrointestinal Microbiome
  • Healthy Volunteers
  • Humans
  • Male
  • Pectins
  • Volatile Organic Compounds
  • Young Adult

Keywords

  • aging
  • dietary fiber
  • elderly
  • exhaled air
  • microbiota
  • pectin
  • young adults


Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines.


MeSH Terms

  • Alkanes
  • Diacetyl
  • Ethanol
  • Fruit and Vegetable Juices
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Hydrogen-Ion Concentration
  • Ketones
  • Limit of Detection
  • Solid Phase Microextraction
  • Stereoisomerism
  • Time Factors
  • Wine

Keywords

  • 3-methyl-2,4-nonanedione
  • Aroma precursor
  • Hydroxy ketones
  • Oxidation
  • Premature aging
  • Wine


Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.


MeSH Terms

  • Adaptive Immunity
  • Adjuvants, Immunologic
  • Aging
  • Animals
  • Animals, Newborn
  • Germinal Center
  • Immunity, Innate
  • Interleukin-13
  • Lymphopoiesis
  • Mice, Inbred C57BL
  • T-Lymphocytes, Helper-Inducer
  • Th2 Cells
  • Transcriptome

Keywords

  • T follicular helper cells
  • adjuvant
  • neonates
  • transcriptional profile analysis
  • vaccines


Identification of Dialkylpyrazines Off-Flavors in Oak Wood.


MeSH Terms

  • Flavoring Agents
  • Gas Chromatography-Mass Spectrometry
  • Odorants
  • Olfactometry
  • Pyrazines
  • Quercus
  • Wood

Keywords

  • aroma
  • barrel aging
  • dialkylpyrazine
  • oak wood
  • off-flavor
  • wine


Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.


Keywords

  • aging
  • biomarker
  • metabolomics
  • sepsis
  • transcriptomics

GCA[править]

Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica.


Keywords

  • Giant cell arteritis
  • Longevity
  • Mortality
  • Polymyalgia rheumatica


Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.


Keywords

  • Aging
  • Alcohol drinking
  • Apolipoprotein E4 (ApoE)
  • Cognitive abilities
  • Male
  • Middle aged
  • Risk factors

GCK[править]

The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing.


MeSH Terms

  • Biomarkers
  • Child
  • Cost-Benefit Analysis
  • Diabetes Mellitus, Type 2
  • Female
  • Genetic Testing
  • Health Care Costs
  • Humans
  • Life Expectancy
  • Male
  • Mass Screening
  • Pedigree
  • Precision Medicine
  • Quality-Adjusted Life Years

GCLC[править]

Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans.


Keywords

  • Aging
  • Exercise
  • GCLC
  • NQO1
  • Nrf2 signaling
  • Redox homeostasis

GCLM[править]

Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Basic-Leucine Zipper Transcription Factors
  • Bronchi
  • Epithelial Cells
  • Gene Expression
  • Gene Silencing
  • Glutamate-Cysteine Ligase
  • Heme Oxygenase-1
  • Humans
  • Isothiocyanates
  • Middle Aged
  • NAD(P)H Dehydrogenase (Quinone)
  • NF-E2-Related Factor 2
  • RNA, Messenger
  • RNA, Small Interfering
  • Signal Transduction
  • Young Adult

Keywords

  • Aging
  • Bach1
  • Glutamate cysteine ligase
  • Heme oxygenase
  • Nrf2
  • Sulforaphane

GDF11[править]

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice.


Keywords

  • GDF11
  • White matter integrity
  • aging
  • gliosis
  • stroke


Anti-Aging Effects of GDF11 on Skin.


Keywords

  • disease
  • growth factors
  • regeneration
  • skin aging


Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and GDF11 in Mouse Serum.


Keywords

  • GDF11
  • aging
  • immunoprecipitation
  • myostatin/GDF8
  • serum
  • targeted-quantitative proteomics


Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.


Keywords

  • aging
  • alveolar bone loss
  • dental implants
  • osseointegration
  • transforming growth factors


Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice.


Keywords

  • GDF11
  • adiponectin
  • aging
  • calorie restriction
  • heterochronic parabiosis
  • rejuvenation


Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases.


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Blood
  • Bone Morphogenetic Proteins
  • Chemokine CCL11
  • Enzyme Therapy
  • Enzymes
  • Growth Differentiation Factors
  • Mice
  • Neurodegenerative Diseases
  • Parabiosis
  • Vascular Diseases

Keywords

  • C-C motif chemokine 11
  • Circulating factor
  • Growth differentiation factor 11
  • Neurodegenerative diseases
  • Neurovascular diseases
  • Young blood


Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice.


Keywords

  • aging
  • exercise
  • growth and differentiation factor 11
  • sarcopenia
  • skeletal muscle

GDF15[править]

Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging.


Keywords

  • AD
  • Aging
  • FGF21
  • GDF15
  • Humanin
  • T2D


Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice.


Keywords

  • T cell
  • aging
  • inflammation
  • mitochondria
  • senescence


Analysis of Epigenetic Age Predictors in Pain-Related Conditions.


Keywords

  • DNA methylation
  • aging biomarker
  • chronic pain
  • epigenetic aging
  • epigenetic clock
  • fibromyalgia
  • headache
  • pain sensitivity


GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness.


Keywords

  • GDF15
  • healthy aging
  • inflammation
  • physical activity
  • sedentarity
  • skeletal muscle


GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis.


MeSH Terms

  • Aged
  • Alveolar Epithelial Cells
  • Animals
  • Bleomycin
  • Bronchoalveolar Lavage Fluid
  • Case-Control Studies
  • Disease Models, Animal
  • Female
  • Gene Expression Profiling
  • Growth Differentiation Factor 15
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Lung
  • Male
  • Mice
  • Middle Aged
  • Respiratory Function Tests
  • Severity of Illness Index
  • Survival Analysis
  • Telomere
  • Transcriptome

Keywords

  • MIC-1
  • NAG-1
  • SASP
  • aging


Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.


MeSH Terms

  • Aging
  • Cells, Cultured
  • Cellular Senescence
  • Colonic Neoplasms
  • Fibroblasts
  • Growth Differentiation Factor 15
  • HEK293 Cells
  • Humans
  • Phenotype
  • RNA, Messenger
  • Tumor Microenvironment

Keywords

  • GDF15
  • colon organoids
  • colorectal cancer
  • microenvironment
  • senescence

GDF5[править]

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Atrophy
  • Calcium Channels, L-Type
  • Denervation
  • Embryo, Mammalian
  • Exons
  • Female
  • Gene Expression Regulation, Developmental
  • Growth Differentiation Factor 5
  • Humans
  • Male
  • Mice
  • Muscles
  • Neuromuscular Junction
  • Organ Size
  • Physical Conditioning, Animal
  • Protein Isoforms
  • RNA Splicing
  • Signal Transduction
  • Young Adult

GDNF[править]

GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion.


MeSH Terms

  • Aging
  • Animals
  • Dopamine
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Neurons
  • Oxidopamine
  • Phosphorylation
  • Rats
  • Substantia Nigra
  • Tyrosine 3-Monooxygenase

Keywords

  • 6-hydroxydopamine
  • Parkinson’s disease
  • Substantia nigra
  • aging
  • nigrostriatal
  • tyrosine hydroxylase

GEM[править]

The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review.


Keywords

  • emergency department
  • geriatric emergency management nurses
  • geriatrics

GFAP[править]

Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging.


Keywords

  • aging
  • dorsal root ganglion
  • satellite cells
  • systemic inflammation


Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.


Keywords

  • Parkinson's disease
  • aging
  • locus ceruleus
  • nonmotor
  • norepinephrine
  • α-synuclein


ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function.


Keywords

  • Alzheimer’s disease
  • ApoE
  • aging
  • antioxidants
  • cognition
  • exercise
  • motor
  • oxidative stress
  • vitamin C
  • vitamin E


Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.


Keywords

  • Sholl analysis
  • aging
  • astrocyte
  • cell morphology
  • heterogeneity
  • olfactory bulb


Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion.


Keywords

  • CD45
  • EA microdispersion (EAm)
  • GFAP
  • aging
  • behavioral skills
  • ellagic acid (EA)
  • mice
  • noradrenaline
  • oral administration
  • principal component analysis (PCA)


Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats.


Keywords

  • Autophagy
  • Behavior
  • Longevity
  • Middle-aged rats
  • Neuroinflammation
  • Spermidine


Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain.


Keywords

  • Aging
  • Meta-analysis
  • Prefrontal cortex
  • Sex-specific
  • Transcriptome


Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain.


Keywords

  • BCAA
  • ER stress
  • aging
  • autophagy
  • lipogenesis
  • mTORC1


Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy.


Keywords

  • Aging
  • chaperone-mediated autophagy
  • endocrine control of autophagy
  • endocrine signaling
  • growth hormone


Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.


Keywords

  • Alzheimer's disease
  • aging
  • lipopolysaccharide
  • memory
  • mice


Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.


MeSH Terms

  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Astrocytes
  • Gene Knock-In Techniques
  • Longevity
  • Mice
  • Mice, Knockout
  • Mice, Obese
  • Microglia
  • Peptide Fragments

Keywords

  • Alzheimer's disease
  • astrocytes
  • diabetes
  • lifespan
  • microglia
  • obesity


Selective brain neuronal and glial losses without changes in GFAP immunoreactivity: Young versus mature adult Wistar rats.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Glial Fibrillary Acidic Protein
  • Male
  • Neuroglia
  • Neurons
  • Rats
  • Rats, Wistar

Keywords

  • Ageing
  • Astrocytes
  • GFAP
  • Glia
  • Neurons

GGCT[править]

Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.


MeSH Terms

  • Antineoplastic Agents
  • Apoptosis
  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Docetaxel
  • Enzyme Inhibitors
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • Male
  • Prostatic Neoplasms
  • RNA, Small Interfering
  • gamma-Glutamylcyclotransferase

Keywords

  • docetaxel
  • pro-GA
  • prostate cancer cells
  • senescence
  • γ-glutamylcyclotransferase

GHR[править]

Tissue-Specific GHR Knockout Mice: An Updated Review.


Keywords

  • aging
  • growth hormone
  • longevity
  • metabolism
  • mice

GHRH[править]

Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone.


Keywords

  • CRISPR
  • GHRH
  • aging
  • lifespan
  • metabolism


Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.


Keywords

  • aging
  • growth hormone
  • metabolite
  • mouse
  • transcriptomics

GIP[править]

Absence of GIP secretion alleviates age-related obesity and insulin resistance.


MeSH Terms

  • Adiponectin
  • Adipose Tissue
  • Age Factors
  • Animals
  • Diet
  • Diet, High-Fat
  • Enteroendocrine Cells
  • Gastric Inhibitory Polypeptide
  • Gene Expression
  • Glucose Tolerance Test
  • Insulin
  • Insulin Resistance
  • Leptin
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Obesity

Keywords

  • GIP
  • aging
  • incretin
  • obesity

GIT2[править]

Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.


MeSH Terms

  • Aging
  • Animals
  • Cluster Analysis
  • Computational Biology
  • Female
  • GTPase-Activating Proteins
  • Hypothalamus
  • Longevity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA
  • Sex Characteristics
  • Signal Transduction
  • Transcriptome

Keywords

  • Aging
  • Female
  • GIT2
  • Hypothalamus
  • Longevity

GJC2[править]

Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging.


Keywords

  • Brain aging
  • Cell adhesion molecules
  • RNA sequencing
  • Zebrafish

GK[править]

Progression of diabetic kidney disease in T2DN rats.


MeSH Terms

  • Aging
  • Albuminuria
  • Animals
  • Blood Glucose
  • Diabetes Mellitus, Type 2
  • Diabetic Nephropathies
  • Disease Progression
  • Hypertrophy
  • Kidney Glomerulus
  • Male
  • Membrane Proteins
  • Organ Size
  • Polyuria
  • Rats
  • Rats, Wistar
  • Renin-Angiotensin System
  • Water-Electrolyte Imbalance

Keywords

  • diabetic glomerular disease
  • diabetic nephropathy
  • podocyte pathology
  • renin-angiotensin-aldosterone system
  • scanning ion microscopy
  • type 2 diabetic nephropathy

GNAQ[править]

GNAQ expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.


MeSH Terms

  • Aging
  • Animals
  • Central Nervous System Neoplasms
  • Disease Models, Animal
  • Disease Progression
  • Embryonic Development
  • Female
  • GTP-Binding Protein alpha Subunits, Gq-G11
  • Male
  • Melanocytes
  • Melanoma
  • Meningeal Neoplasms
  • Mice, Transgenic
  • Multipotent Stem Cells
  • Mutation
  • Neoplasm Invasiveness
  • Neural Crest
  • Nevus
  • Skin Neoplasms
  • Uveal Neoplasms

Keywords

  • GNAQ
  • Plp1
  • blue nevus
  • leptomeningeal melanocytoma
  • uveal melanoma

GNE[править]

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice.


Keywords

  • Aging
  • Dnm1l/DRP1
  • SQSTM1/p62
  • knockin mice
  • macroautophagy
  • mitochondria dysfunction
  • mitochondrial fission
  • mitophagy
  • parkinson disease
  • ubiquitination

GPC1[править]

Decreased expression of GPC1 in human skin keratinocytes and epidermis during ageing.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cell Proliferation
  • Cells, Cultured
  • Epidermis
  • Female
  • Fibroblast Growth Factor 2
  • Gene Expression Regulation
  • Glypicans
  • Humans
  • Keratinocytes
  • Middle Aged
  • RNA, Messenger
  • Signal Transduction
  • Skin
  • Young Adult

Keywords

  • Ageing
  • Epidermis
  • Glypican 1
  • Human skin
  • Keratinocytes

GPI[править]

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain.


MeSH Terms

  • Aging
  • Animals
  • Blood Circulation
  • Brain
  • Cognition
  • Cognitive Dysfunction
  • Glycosylphosphatidylinositols
  • Liver
  • Mice
  • Neurogenesis
  • Phospholipase D
  • Physical Conditioning, Animal
  • Regeneration
  • Signal Transduction

GPR6[править]

Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy.


Keywords

  • HIV
  • aging
  • epigenetics
  • methylation

GPT[править]

Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan.


Keywords

  • aging
  • gray matter
  • visuomotor function
  • white matter

GPX1[править]

Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.


Keywords

  • glutathione peroxidase-1
  • kidney aging
  • mitochondria
  • proteomics
  • reactive oxygen species

GPX3[править]

Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.


MeSH Terms

  • Aging
  • Anterior Capsule of the Lens
  • Apoptosis
  • Cataract
  • Cell Line
  • Cell Nucleus
  • Epithelial Cells
  • Glutathione Peroxidase
  • Humans
  • Hydrogen Peroxide
  • Lens, Crystalline
  • RNA, Long Noncoding
  • Up-Regulation

GPX4[править]

l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes.


MeSH Terms

  • Animals
  • Carnitine
  • Cattle
  • Culture Media
  • Embryo Culture Techniques
  • Female
  • Fertilization in Vitro
  • In Vitro Oocyte Maturation Techniques
  • Oocytes
  • Oxidative Stress

Keywords

  • Bovine
  • Embryo development
  • Oocyte aging
  • l-carnitine


Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice.


Keywords

  • GPX4
  • Gpx1
  • Gpx3
  • Selenof
  • apoptosis
  • embryo
  • follicle development
  • ovarian aging
  • selenium
  • selenoprotein

GREM1[править]

GREM1 inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells.


Keywords

  • BMP
  • GREM1
  • adipose-derived stem cells (ADSCs)
  • osteogenic differentiation
  • senescence

GREM2[править]

Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis.


Keywords

  • Adipogenic differentiation
  • Adipose-derived stromal/stem stem cells
  • Aging
  • DAPI, 4′,6-diamidino-2-phenylindole
  • FGF, fibroblast growth factor
  • GREM2
  • GREM2 knockdown
  • HE, hematoxylin eosin
  • Individual differences
  • PBS, phosphate buffered Solution
  • PFA, paraformaldehyde
  • TGF-β, transforming growth factor beta

GRID1[править]

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.


Keywords

  • GWAS
  • HDL-C metabolism
  • Healthy aging
  • Longevity
  • Longitudinal HDL-C change

GRIK2[править]

Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2.


Keywords

  • GluR6
  • Grik2
  • Senescence
  • cancer
  • glutamate receptor
  • normal fibroblasts

GRK2[править]

G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.


Keywords

  • Aging
  • Caenorhabditis elegans (C. elegans)
  • G protein coupled receptor kinase (GRK)
  • Oxidative stress
  • Resistance
  • Stress response


G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.


Keywords

  • Aging
  • Biological control
  • Caenorhabditis elegans (C. elegans)
  • G protein coupled receptor (GPCR)
  • G protein coupled receptor kinase (GRK)
  • Heat stress
  • Resistance
  • Stress response


Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging.


MeSH Terms

  • Aging
  • Animals
  • Female
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • Heart
  • Heart Diseases
  • Homeostasis
  • Male
  • Mice
  • Mutation
  • Myocardium
  • Nitric Oxide

Keywords

  • S-nitrosylation
  • cardiac hypertrophy
  • heart disease

GRM3[править]

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Bipolar Disorder
  • Dentate Gyrus
  • Depressive Disorder, Major
  • Female
  • Gene Expression Profiling
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Neurons
  • Quantitative Trait Loci
  • Schizophrenia
  • Transcriptome
  • Young Adult

GRN[править]

Stressful development: Integrating endoderm development, stress, and longevity.


Keywords

  • Caenorhabditis elegans
  • Embryonic development
  • Epigenetics inheritance
  • Innate immunity
  • Longevity
  • Pleiotropy
  • Stress


A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program.


Keywords

  • Aging
  • Geriatric nursing
  • Health care professionals
  • Intervention
  • Quality improvement

GSC[править]

[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Germ Cells
  • Nuclear Proteins
  • Ovary
  • Receptors, Notch
  • Signal Transduction
  • Stem Cell Niche
  • Transcriptome

Keywords

  • DE-cadherin
  • Drosophila oogenesis
  • Hedgehog
  • mastermind
  • niche ageing
  • reactive oxygen species

GSTM1[править]

The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators.


Keywords

  • Biological aging
  • DNA adduct
  • Mitochondrial DNA copy number
  • Polycyclic aromatic hydrocarbon
  • Structural equation modelling
  • Telomere length

GSTM2[править]

Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage.


Keywords

  • 4-HNE
  • EV
  • GSH
  • GST
  • ROS
  • SASP
  • aging
  • extracellular vesicles
  • glutathione metabolism
  • glutathione-S-transferase
  • lipid peroxidation
  • rejuvenation
  • senescence
  • senescence-associated secretory phenotype

GUK1[править]

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.


Keywords

  • Aging
  • GDP
  • GMP
  • Mycophenolic acid
  • Proteasome
  • Replicative lifespan
  • Yeast

GZMK[править]

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK CD8 T Cells as Conserved Hallmark of Inflammaging.


Keywords

  • Aging
  • CD8 T cells
  • CITE-seq
  • granzyme K
  • immune system
  • inflammaging
  • single-cell ATAC-sequencing
  • single-cell BCR-sequencing
  • single-cell RNA-sequencing
  • single-cell TCR-sequencing

H2AX[править]

Evaluation of GammaH2AX in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing.


Keywords

  • Alzheimer’s disease
  • DNA damage
  • mild cognitive impairment
  • senescence
  • γH2AX


Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response.


Keywords

  • cisplatin
  • neuropathy
  • neurotoxicity
  • p21
  • senescence


Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites.


Keywords

  • DNA damage
  • UV-induced keratinocyte senescence
  • guanine deaminase
  • reactive oxygen species
  • uric acid
  • seborrhoeic keratosis


Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • BRCA1 Protein
  • BRCA2 Protein
  • Female
  • Germ-Line Mutation
  • Heterozygote
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Observational Studies as Topic
  • Ovarian Follicle
  • Ovarian Reserve
  • Prospective Studies
  • Research Design
  • Young Adult

Keywords

  • BRCA
  • DNA repair
  • fertility
  • follicle
  • germline mutation
  • oocyte


Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.


MeSH Terms

  • Animals
  • Birds
  • Bottle-Nosed Dolphin
  • Cross-Sectional Studies
  • DNA Damage
  • Goats
  • Leukocytes
  • Longevity
  • Reindeer
  • Turtles
  • Vertebrates

Keywords

  • DNA damage
  • lifespan
  • short telomeres
  • species


Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone H2AX phosphorylation in plant growth under genotoxic stress.


MeSH Terms

  • ATP-Binding Cassette Transporters
  • Aging
  • Arabidopsis
  • Arabidopsis Proteins
  • Cells, Cultured
  • DNA Damage
  • DNA Repair
  • Gene Expression Regulation, Plant
  • Gene Ontology
  • Germination
  • Histones
  • Mass Spectrometry
  • Phosphorylation
  • Proteome
  • Seeds
  • Serine
  • Signal Transduction
  • Stress, Physiological
  • X-Rays

Keywords

  • ATAXIA TELANGIECTASIA MUTATED (ATM)
  • DNA damage response
  • DNA repair
  • phosphorylation
  • seed

HBM[править]

The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis.


MeSH Terms

  • Adipose Tissue
  • Adiposity
  • Animals
  • Bone Density
  • Bone Marrow
  • Dietary Fats
  • Dietary Supplements
  • Disease Models, Animal
  • Fatty Acids, Omega-3
  • Female
  • Femur
  • Mice
  • Osteoporosis
  • X-Ray Microtomography

Keywords

  • SAMP8 mouse
  • aging
  • fish oil
  • marrow adipose tissue
  • osteoporosis

HBP1[править]

Suppression of p38/HBP1 pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence.


MeSH Terms

  • Cellular Senescence
  • Chondrocytes
  • Disease Progression
  • High Mobility Group Proteins
  • Humans
  • Osteoarthritis
  • Repressor Proteins
  • Up-Regulation
  • p38 Mitogen-Activated Protein Kinases

Keywords

  • HBP1
  • chondrocyte
  • osmolality stress
  • p38
  • senescence

HCN1[править]

Protein expression changes of HCN1 and HCN2 in hippocampal subregions of gerbils during the normal aging process.


Keywords

  • Aging
  • Dentate gyrus
  • Granule cells
  • HCN channel
  • Hippocampus proper
  • Pyramidal cells

HDAC1[править]

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.


MeSH Terms

  • Acetylation
  • Aging
  • Alzheimer Disease
  • Animals
  • Astrocytes
  • Base Sequence
  • Benzophenones
  • Brain
  • Cognition
  • Cognition Disorders
  • DNA Damage
  • DNA Glycosylases
  • Down-Regulation
  • Gene Ontology
  • Guanine
  • Histone Deacetylase 1
  • Memory
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Neurons
  • Oxidative Stress
  • Promoter Regions, Genetic

HDAC10[править]

Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge.


MeSH Terms

  • Acetylation
  • Age Factors
  • Animals
  • Estradiol
  • Female
  • Histones
  • Hypothalamus, Anterior
  • Luteinizing Hormone
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • Histone acetylation
  • LH
  • aging
  • histone deacetylases
  • hypothalamus

HDAC2[править]

EEF1A1 deacetylation enables transcriptional activation of remyelination.


MeSH Terms

  • Acetylation
  • Aging
  • Animals
  • Cell Dedifferentiation
  • Cell Nucleus
  • Histone Deacetylase 1
  • Histone Deacetylase 2
  • Lysine Acetyltransferase 5
  • Mice
  • Models, Biological
  • Oligodendroglia
  • Peptide Elongation Factor 1
  • Peripheral Nervous System
  • Recovery of Function
  • Remyelination
  • SOXE Transcription Factors
  • STAT3 Transcription Factor
  • Schwann Cells
  • Theophylline
  • Trans-Activators
  • Transcriptional Activation

HDAC3[править]

Histone deacetylase-3: Friend and foe of the brain.


Keywords

  • Histone deacetylases
  • aging
  • histone deacetylase-3
  • learning and memory
  • neurodegenerative diseases
  • neurodevelopment


Loss of HDAC3 contributes to meiotic defects in aged oocytes.


MeSH Terms

  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Female
  • Histone Deacetylases
  • Meiosis
  • Mice
  • Mice, Inbred ICR
  • Oocytes

Keywords

  • HDACs
  • aneuploidy
  • maternal aging
  • oocyte quality
  • reproduction

HDAC4[править]

The posttranslational modification of HDAC4 in cell biology: Mechanisms and potential targets.


Keywords

  • HDAC4
  • cell senescence
  • cellular apoptosis and autophagy
  • glucose metabolism
  • inflammation and pathology
  • proliferation and differentiation

HDAC6[править]

Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy.


Keywords

  • HDAC6
  • diabetic retinopathy
  • oxidative stress
  • retinal endothelial cell senescence
  • retinal endothelial cells
  • tubastatin A

HDC[править]

Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells.


MeSH Terms

  • Adult
  • Aged, 80 and over
  • Cell Differentiation
  • Cell Line
  • Cellular Reprogramming
  • Cellular Senescence
  • Child
  • Clone Cells
  • Gene Expression Regulation
  • Humans
  • Induced Pluripotent Stem Cells
  • Mesenchymal Stem Cells
  • Telomere Homeostasis
  • Tissue Donors
  • Transcriptome

Keywords

  • Aging
  • Longevity
  • Reprogramming
  • Supercentenarian
  • Telomere
  • iPSC

HES1[править]

A Single-Cell Transcriptomic Atlas of Human Skin Aging.


Keywords

  • HES1
  • KLF6
  • aging
  • fibroblast
  • keratinocyte
  • quercetin
  • senescence
  • single-cell RNA sequencing
  • skin

HFE[править]

Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae).


Keywords

  • Himantoglossum robertianum
  • antioxidants
  • collagenase
  • elastase
  • flavonoids
  • keratinocytes
  • skin aging

HGD[править]

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Diet
  • Gene Expression Regulation
  • Glucose
  • Longevity
  • Mitochondria
  • Mitophagy

HGF[править]

Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets.


Keywords

  • Aging
  • CD4 T cell
  • Dental pulp
  • Immunomodulation
  • Mesenchymal stem cell


Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.


Keywords

  • Hepatocyte growth factor
  • Mitochondrial function
  • Osteogenic differentiation
  • Senescence
  • Stem cell factor
  • Stem cells from human exfoliated deciduous teeth
  • Stemness


Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy.


Keywords

  • aging
  • autophagy
  • gingival fibroblast
  • phenytoin sodium


Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver.


Keywords

  • aging
  • hepatic stellate cells
  • integrins
  • laminins
  • mechanobiology

HGS[править]

Handgrip strength asymmetry is associated with future falls in older Americans.


Keywords

  • Aging
  • Functional laterality
  • Geriatric assessment
  • Geriatrics
  • Muscle strength dynamometer


Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study.


Keywords

  • aging
  • geriatric assessment
  • muscle strength
  • muscle weakness
  • physical functional performance


The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity.


Keywords

  • aging
  • depression
  • disease comorbidities
  • muscular strength


Handgrip Strength in the Korean Population: Normative Data and Cutoff Values.


Keywords

  • Aging
  • Hand strength
  • Muscle strength
  • Nutrition surveys
  • Sarcopenia


Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study.


Keywords

  • aging
  • functional laterality
  • geriatric assessment
  • geriatrics
  • muscle strength dynamometer


Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle Strength Dynamometer
  • Muscle Weakness
  • Odds Ratio
  • United States

Keywords

  • aging
  • geriatrics
  • muscle strength
  • muscle strength dynamometer
  • nutrition surveys


Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans.


Keywords

  • aging
  • epidemiology
  • hand strength
  • human development
  • muscle weakness


Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Cross-Sectional Studies
  • Entropy
  • Female
  • Hand Strength
  • Heart Rate
  • Humans
  • Male

Keywords

  • Aging
  • Entropy
  • Hand grip strength
  • Nonlinear dynamics
  • Poincaré plot
  • Time series


Physical Activity and Fitness in White- and Blue-Collar Retired Men.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Body Mass Index
  • Exercise
  • Geriatric Assessment
  • Humans
  • Longitudinal Studies
  • Male
  • Men's Health
  • Occupations
  • Physical Fitness
  • Poland
  • Retirement
  • Social Class
  • Surveys and Questionnaires
  • Task Performance and Analysis

Keywords

  • Retirement
  • occupation
  • old men
  • physical activity


Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens.


Keywords

  • Hand Grip Strength
  • Korean Longitudinal Study of Aging
  • Self-Rated Health


Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis.


Keywords

  • Aging
  • Epidemiology
  • Geriatrics
  • hand strength
  • muscle strength
  • sarcopenia


Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016.


Keywords

  • Dietary patterns
  • Korea National Health and Nutrition Examination Survey
  • aging
  • diet
  • handgrip strength


Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016).


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cardiovascular Diseases
  • Female
  • Hand Strength
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Muscle Strength
  • Muscle, Skeletal
  • Republic of Korea
  • Risk Factors

Keywords

  • Cardiovascular disease
  • KLoSA
  • Relative handgrip strength


Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aging
  • Cognitive Dysfunction
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Middle Aged

Keywords

  • Dementia
  • Epidemiology
  • Geriatrics
  • Muscle strength
  • Nervous system


Association of phase angle with sarcopenia and its components in physically active older women.


MeSH Terms

  • Aged
  • Cross-Sectional Studies
  • Electric Impedance
  • Female
  • Hand Strength
  • Humans
  • Muscle Strength
  • Sarcopenia
  • Walking Speed

Keywords

  • Aging
  • Bioimpedance
  • Muscle function
  • Muscle mass

HLA-DRB1[править]

The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle.


Keywords

  • Aging
  • B cell
  • HLA-DR
  • Interleukin-6
  • Polymyalgia rheumatica
  • T cell

HMGA1[править]

Characterization of [i]HMGA1P6[/i] transgenic mouse embryonic fibroblasts.


Keywords

  • CeRNA
  • HMGA1
  • HMGA1P6
  • pseudogenes
  • senescence

HMGA2[править]

4D Genome Rewiring during Oncogene-Induced and Replicative Senescence.


MeSH Terms

  • Cells, Cultured
  • Cellular Senescence
  • Chromatin Assembly and Disassembly
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA Methylation
  • Fibroblasts
  • Genome, Human
  • Heterochromatin
  • Humans
  • In Situ Hybridization, Fluorescence
  • Oncogenes

Keywords

  • 3D genome architecture
  • DNMT1
  • Hi-C
  • chromatin compartments
  • gene regulation
  • oncogene-induced senescence
  • replicative senescence
  • senescence


The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells.


Keywords

  • bone marrow derived mesenchymal stromal cells (MSCs)
  • high-mobility group AT-hook 2 (HMGA2)
  • regulator of G protein signaling 2 (Rgs2)
  • senescence

HMGB1[править]

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Atrophy
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Epidermis
  • Female
  • Humans
  • Male
  • Melanocytes
  • Middle Aged
  • Paracrine Communication
  • Reactive Oxygen Species
  • Receptors, CXCR4
  • Skin
  • Telomere
  • Young Adult

Keywords

SASP

  • melanocytes
  • senescence
  • skin ageing
  • telomeres

HMGCR[править]

Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms.


Keywords

  • aging
  • cholesterol biosynthesis
  • mathematical model
  • reactive oxygen species
  • systems biology


Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence.


Keywords

  • artesunate
  • distant seeding
  • glioma
  • mevalonate pathway
  • senescence

HOXD8[править]

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts.


Keywords

  • Hoxd8
  • cellular senescence
  • mouse embryonic fibroblasts
  • senescence-associated secretory phenotype
  • single-cell RNA sequencing
  • transcriptomic heterogeneity

HP[править]

A narrative review of highly processed food addiction across the lifespan.


Keywords

  • Adolescence
  • Adulthood
  • Childhood
  • Food addiction
  • Infancy
  • Lifespan
  • Prenatal


Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis.


MeSH Terms

  • Apoptosis
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Cytochalasin B
  • Cytokinesis
  • DNA Repair
  • E1A-Associated p300 Protein
  • Gene Expression Regulation
  • HCT116 Cells
  • Host-Pathogen Interactions
  • Humans
  • Keratinocytes
  • Oncogene Proteins, Viral
  • Osteoblasts
  • Papillomaviridae
  • Phenotype
  • Phosphorylation
  • Primary Cell Culture
  • Protein-Serine-Threonine Kinases
  • Signal Transduction
  • Transcription Factors
  • Tumor Suppressor Protein p53

Keywords

  • Hippo signaling pathway
  • apoptosis
  • cancer
  • cytokinesis
  • human papillomavirus
  • senescence
  • skin cancer

HPSE[править]

Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin.


Keywords

  • aging
  • estrogen
  • extracellular matrix
  • heparan sulfate
  • heparanase-1
  • matrix metalloproteinase-9

HR[править]

Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities.


Keywords

  • Aging
  • Cardiovascular reactivity
  • Heart rate variability
  • Hip fracture
  • Total hip arthroplasty


Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study.


Keywords

  • Aging
  • Coronavirus disease
  • Elderly
  • Lung ultrasound
  • Severe acute respiratory syndrome-coronavirus-2


The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.


Keywords

  • Accelerometer
  • Longevity
  • Physical activity


Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running.


Keywords

  • Aging
  • Exercise
  • Mouse model
  • Muscle morphology
  • Skeletal muscle
  • Training


Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors.


Keywords

  • aging
  • body composition
  • gender
  • heart disease
  • lean mass
  • obesity
  • primary prevention
  • women


Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up.


Keywords

  • Aging
  • Body mass index
  • Bone mineral density
  • Follow-up study
  • General population
  • Hip fracture
  • Menopause
  • Obesity


ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells.


Keywords

  • Biochemistry
  • Bioinformatics
  • Cancer research
  • Cell biology
  • Cellular metabolism
  • Cellular senescence
  • Drug combinations
  • Homologous recombination
  • Metabolite
  • Molecular biology
  • PPARa


Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach.


Keywords

  • aging
  • cancer
  • chemotherapy
  • comparative effectiveness research
  • pharmacoepidemiology


Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care.


MeSH Terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Betacoronavirus
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Female
  • Frail Elderly
  • Geriatrics
  • Humans
  • Male
  • Models, Statistical
  • Outcome Assessment, Health Care
  • Pandemics
  • Pneumonia, Viral
  • Prognosis
  • SARS-CoV-2
  • Survival Analysis
  • Sweden

Keywords

  • COVID-19
  • aging
  • comorbidity
  • frailty
  • geriatrics
  • survival


Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients.


Keywords

  • Aging
  • Cox regression
  • Dementia
  • Follow-up
  • Mild cognitive impairment


Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women.


Keywords

  • DHEA-S
  • aging
  • heart failure
  • mortality


High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults.


Keywords

  • Aging
  • Body composition
  • Exercise
  • Mobility
  • Nutrition


Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study.


Keywords

  • Aging
  • Blood pressure
  • Falls
  • Injury
  • Swedish National study on Aging and Care in Kungsholmen (SNAC-K)


Epigenetic age acceleration and clinical outcomes in gliomas.


MeSH Terms

  • Adult
  • Aging
  • DNA Methylation
  • Epigenesis, Genetic
  • Female
  • Glioma
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Survival Analysis


Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out?


Keywords

  • active aging
  • activity monitor
  • homebound
  • mobility
  • walk-up buildings


Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt.


Keywords

  • arterial function
  • arterial stiffness
  • blood pressure
  • early vascular aging
  • pressure dependence


Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication.


MeSH Terms

  • Aged
  • Cardiac Surgical Procedures
  • Elective Surgical Procedures
  • Female
  • Frailty
  • Humans
  • Male
  • Patient Readmission
  • Postoperative Complications
  • Retrospective Studies
  • Risk

Keywords

  • adverse events
  • aging
  • cardiac surgery
  • frailty
  • rehospitalization


Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study.


MeSH Terms

  • Aged, 80 and over
  • Creatinine
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney Function Tests
  • Longevity
  • Male
  • Mortality
  • Predictive Value of Tests
  • Renal Insufficiency
  • Reproducibility of Results
  • Risk Factors

Keywords

  • equation
  • exceptional longevity
  • glomerular filtration rate
  • kidney function
  • mortality


Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomass
  • Body Composition
  • Body Weight
  • Dietary Proteins
  • Female
  • Humans
  • Independent Living
  • Male
  • Muscle Development
  • Muscle Strength
  • Muscles
  • Prospective Studies
  • Sex Factors

Keywords

  • appendicular lean body mass
  • community-dwelling
  • gait speed
  • mobility limitation
  • old age
  • optimal intake
  • physical performance
  • spline functions


Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT.


MeSH Terms

  • Absorptiometry, Photon
  • Adult
  • Aged
  • Aging
  • Asian Continental Ancestry Group
  • Bone Density
  • Bone and Bones
  • Cancellous Bone
  • Cortical Bone
  • Female
  • Finite Element Analysis
  • Humans
  • Japan
  • Linear Models
  • Menopause
  • Middle Aged
  • Porosity
  • Tomography, X-Ray Computed

Keywords

  • Bone microstructure
  • Estimated bone strength
  • High resolution peripheral quantitative CT (HR-pQCT)
  • Japanese women
  • Non-metric trabecular parameter


Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes.


Keywords

  • aging
  • diabetes
  • mortality
  • nutritional support
  • protein intake


CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aging
  • Cohort Studies
  • Europe
  • Humans
  • Independent Living
  • Male
  • Middle Aged
  • Mortality
  • Proportional Hazards Models
  • Prospective Studies
  • Retirement
  • Risk Factors
  • Surveys and Questionnaires

Keywords

  • Aging
  • Comorbidity
  • Depressive symptoms
  • Diseases
  • Mortality risk


Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men.


Keywords

  • arterial wave reflection
  • cardiovascular biomarker
  • optimum cardiovascular function
  • vascular aging
  • wave condition number


Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition.


Keywords

BRCA1

  • DNA repair
  • cellular aging
  • homologous recombination
  • mesenchymal stem cells


Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults.


Keywords

  • aging
  • alertness
  • balance
  • blood pressure
  • heart rate
  • heart rate variability
  • light
  • sleep inertia


Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance.


Keywords

  • aging
  • heart rate deflection
  • intensity prescription
  • maximal heart rate
  • sex differences
  • ß1-receptor sensitivity


Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging.


Keywords

  • Adverse outcomes
  • Healthy aging
  • Mortality
  • Older adults
  • Physical activity
  • Trajectories


U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men.


Keywords

  • estradiol
  • fracture
  • male aging
  • osteoporosis
  • sex hormone-binding globulin
  • testosterone


Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.


Keywords

  • AGING
  • ANALYSIS/QUANTITATION OF BONE
  • BONE QCT/μCT
  • EPIDEMIOLOGY
  • GENERAL POPULATION STUDIES


Analysis of the world record time for combined father and son marathon.


Keywords

  • V̇o2max
  • aerobic exercise
  • aging
  • endurance
  • oxygen consumption
  • running


Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis.


Keywords

  • Aging
  • autonomic nervous system
  • heat stress
  • parasympathetic nervous system
  • relative humidity
  • sympathetic nervous system


Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Benzhydryl Compounds
  • Cardiovascular System
  • Diabetes Mellitus, Type 2
  • Diabetic Ketoacidosis
  • Female
  • Glucosides
  • Humans
  • Hypoglycemia
  • Hypoglycemic Agents
  • Incidence
  • Kidney
  • Male
  • Middle Aged
  • Sodium-Glucose Transporter 2 Inhibitors
  • Survival Analysis
  • Treatment Outcome
  • Urinary Tract Infections


Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation.


MeSH Terms

  • Adolescent
  • Aging
  • Body Mass Index
  • Exercise
  • Exercise Test
  • Female
  • Heart Rate
  • Humans

Keywords

  • cardiac rate
  • exercise prescription
  • exercise testing
  • prediction equations
  • training zones
  • volleyball


Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells.


MeSH Terms

  • Adipose Tissue
  • Adult
  • Aging
  • DNA Breaks, Double-Stranded
  • DNA End-Joining Repair
  • DNA Repair
  • Humans
  • Middle Aged
  • Recombinational DNA Repair
  • Stem Cells
  • Up-Regulation
  • X-ray Repair Cross Complementing Protein 1
  • Young Adult

Keywords

  • XRCC1
  • adipose-derived stem cells
  • base excision repair
  • genome integrity
  • human aging


Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study.


Keywords

  • AGING
  • EPIDEMIOLOGY
  • GENERAL POPULATION STUDIES
  • OSTEOPOROSIS
  • STATISTICAL METHODS


Malnutrition as a Strong Predictor of the Onset of Sarcopenia.


MeSH Terms

  • Aged
  • Aging
  • Cohort Studies
  • Female
  • Humans
  • Independent Living
  • Male
  • Malnutrition
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Sarcopenia

Keywords

  • EWGSOP2
  • GLIM
  • SarcoPhAge
  • malnutrition
  • sarcopenia


Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.


Keywords

  • Aging
  • Cardiac autonomic modulation
  • Heart rate
  • Heart rate variability
  • Thermoneutrality


Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.


MeSH Terms

  • Aged
  • Apolipoproteins E
  • Cognitive Dysfunction
  • Dementia
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Life Style
  • Male
  • Protective Factors
  • Risk Assessment
  • Risk Factors

Keywords

  • cognitive aging
  • cohort study
  • dementia
  • epidemiology
  • lifestyle
  • prevention
  • risk factors


Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women.


Keywords

  • Aging
  • Bone mineral density
  • Chronic kidney disease
  • Estimated glomerular filtration rate
  • Fracture
  • Women


Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study.


MeSH Terms

  • Age of Onset
  • Aged
  • Aging
  • Biomarkers
  • Cohort Studies
  • DNA
  • DNA Damage
  • Diabetes Mellitus, Type 2
  • Dinoprost
  • Female
  • Follow-Up Studies
  • Germany
  • Humans
  • Incidence
  • Lipid Peroxidation
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Oxidative Stress
  • RNA


Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults.


Keywords

  • cardio-protection
  • exercise
  • longevity
  • non-communicable diseases
  • physical activity


Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Blood Pressure
  • Brain
  • Cerebrovascular Circulation
  • Female
  • Heart Rate
  • Humans
  • Hypoxia
  • Male
  • Pulmonary Ventilation
  • Ultrasonography, Doppler, Transcranial
  • Young Adult

Keywords

  • Aging
  • Arterial oxygen saturation
  • Cerebral blood flow
  • Cerebral tissue oxygenation
  • Heart rate
  • Hypoxemia
  • Ventilation


Vestibulo-sympathetic reflex in patients with bilateral vestibular loss.


MeSH Terms

  • Aging
  • Bilateral Vestibulopathy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reflex, Abnormal
  • Sympathetic Nervous System

Keywords

  • bilateral vestibular loss
  • compensation
  • multisensory integration
  • otolithic system
  • vestibulo-sympathetic reflex


Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome.


MeSH Terms

  • Animals
  • Autonomic Nervous System
  • Blood Pressure
  • Circadian Rhythm
  • Down Syndrome
  • Heart Rate
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Vascular Stiffness

Keywords

  • Aging
  • arterial stiffness
  • autonomic nervous system
  • circadian
  • pulse wave velocity
  • spectral analysis


Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs.


MeSH Terms

  • Adipose Tissue
  • Animals
  • Body Composition
  • Body Weight
  • Dogs
  • Longevity
  • Longitudinal Studies
  • Survival Analysis

Keywords

  • Cohort
  • Cox
  • DEXA
  • Dogs
  • Fat mass
  • Healthspan
  • Lean mass
  • Lean to fat ratio
  • Longevity
  • Sarcopenia


Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group
  • Diet
  • Female
  • Health Surveys
  • Humans
  • Indigenous Peoples
  • Longevity
  • Male
  • Mortality
  • Nutrition Surveys
  • Nutritional Status
  • Risk Factors
  • Taiwan


Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognitive Dysfunction
  • Dementia
  • Exercise
  • Female
  • Heart Failure
  • Heterozygote
  • Humans
  • Hypertension
  • Male
  • Pennsylvania
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Stroke

Keywords

  • Alzheimer‘s disease (AD)
  • apolipoprotein E (APOE)
  • cerebral vascular disease (CVD)
  • dementia
  • epidemiology


Work Ability and Job Survival: Four-Year Follow-Up.


MeSH Terms

  • Adult
  • Brazil
  • Employment
  • Female
  • Follow-Up Studies
  • Hospitals
  • Humans
  • Male
  • Proportional Hazards Models
  • Work Capacity Evaluation

Keywords

  • aging
  • healthcare worker
  • life course
  • longitudinal studies
  • prolonged work career
  • work ability


Predictivity of bioimpedance phase angle for incident disability in older adults.


Keywords

  • Aging
  • Body composition
  • Cellular health
  • Muscle mass
  • Nutrition

HRAS[править]

How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands?


MeSH Terms

  • Adult
  • Alcohol Drinking
  • Attitude to Health
  • Cluster Analysis
  • Diagnostic Self Evaluation
  • Diet, Healthy
  • Exercise
  • Female
  • Health Risk Behaviors
  • Humans
  • Life Expectancy
  • Life Style
  • Logistic Models
  • Male
  • Middle Aged
  • Netherlands
  • Prevalence
  • Sedentary Behavior
  • Smoking
  • Surveys and Questionnaires
  • Young Adult

Keywords

  • Clustering risk attitude
  • Health behaviours
  • Subjective health
  • Time orientation


Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype.


Keywords

  • proteoform
  • quantitative proteomics
  • secretome
  • senescence
  • top-down proteomics

HS2ST1[править]

Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity.


MeSH Terms

  • Animals
  • Avian Proteins
  • Birds
  • Endangered Species
  • Immunity
  • Longevity
  • Polymorphism, Genetic
  • Species Specificity
  • Transcriptome
  • Whole Genome Sequencing

Keywords

  • genome
  • longevity
  • red-crowned crane

HSF1[править]

A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse.


Keywords

  • HSF1
  • PP2A
  • aging
  • mitochondria
  • molecular chaperones
  • protein aggregation
  • proteostasis
  • stress responses


Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Heat Shock Transcription Factors
  • High-Temperature Requirement A Serine Peptidase 2
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart
  • Myocytes, Cardiac
  • NIH 3T3 Cells
  • Transcriptional Activation
  • Up-Regulation

Keywords

  • Omi/HtrA2
  • age-related pathology
  • cardiovascular
  • mitochondria
  • transcriptional regulation


Multifactorial Attenuation of the Murine Heat Shock Response With Age.


Keywords

  • Aging
  • HSF1
  • Stress

HSPA1A[править]

Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Cholecalciferol
  • Epididymis
  • Male
  • Rats
  • Rats, Wistar
  • Spermatozoa

Keywords

  • aging
  • apoptosis
  • oxidative stress
  • sperm

HSPA1L[править]

Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway.


Keywords

  • HSPA1L
  • melatonin
  • mesenchymal stem cells
  • mitochondria
  • mitophagy
  • replicative senescence

HTT[править]

Biological Aging and the Cellular Pathogenesis of Huntington's Disease.


Keywords

  • Biological aging
  • DNA damage
  • Huntington’s disease
  • cellular aging
  • microsatellite instability
  • neurodegeneration
  • oxidative stress
  • proteostasis
  • telomere

ICE1[править]

ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1.


Keywords

  • ATBS1-INTERACTING FACTOR 2 (AIF2)
  • Arabidopsis
  • C-REPEAT BINDING FACTOR (CBF)
  • INDUCER OF CBF EXPRESSION 1 (ICE1)
  • PHYTOCHROME-INTERACTING FACTORS (PIFs)
  • basic helix–loop–helix (bHLH)
  • brassinosteroid (BR)
  • leaf senescence

IDE[править]

Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.


Keywords

  • Aging
  • Dendrobium nobile Lindl. alkaloid (DNLA)
  • amyloid-β
  • autophagy
  • metformin
  • senescence accelerated mouse prone 8 (SAMP8)

IDH2[править]

Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions.


MeSH Terms

  • Animals
  • Cellular Senescence
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinase Inhibitor p21
  • Embryo, Mammalian
  • Fibroblasts
  • Isocitrate Dehydrogenase
  • Mice
  • Mice, Knockout
  • NIH 3T3 Cells
  • Reactive Oxygen Species

Keywords

  • cell cycle
  • cyclin-dependent kinase 2 (Cdk2)
  • isocitrate dehydrogenase 2 (IDH2)
  • reactive oxygen species (ROS)
  • senescence

IDS[править]

Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays.


Keywords

  • Aging
  • Ceramic
  • Fracture strength
  • Immediate dentin sealing
  • Inlay
  • Overlay

IFI27[править]

Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct.


Keywords

  • epidermis
  • keratinocytes
  • reactive oxygen species
  • senescence
  • skin aging
  • ultraviolet radiation

IGF1[править]

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.


Keywords

  • IGF1
  • antagonistic gene
  • female sexual maturation
  • lifespan variation
  • maximum lifespan
  • sex difference in lifespan


17α-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner.


Keywords

  • 17α-estradiol
  • aging
  • growth hormone
  • insulin
  • insulin-like growth factor-1
  • liver


Pan-mammalian analysis of molecular constraints underlying extended lifespan.


Keywords

  • RERconverge
  • computational biology
  • evolution
  • genetics
  • genomics
  • longevity
  • mammals
  • phylogenomics
  • systems biology


17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.


Keywords

  • Follicles
  • Ovarian aging
  • Ovarian reserve
  • Reproductive lifespan

IGF1R[править]

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice.


Keywords

  • Aging mice
  • Hair growth
  • Mitochondrial transplantation
  • Pep-1
  • Platelet-rich plasma

IGFBP1[править]

Role of IGFBP1 in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Atherosclerosis
  • Cells, Cultured
  • Cellular Senescence
  • Coronary Artery Disease
  • Coronary Vessels
  • Down-Regulation
  • Endothelial Cells
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1
  • Jagged-1 Protein
  • Male
  • Middle Aged
  • Signal Transduction
  • Up-Regulation

IGFBP2[править]

Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21.


Keywords

  • insulin-like growth factor binding protein 2
  • keratinocytes
  • p21CIP1/WAF1
  • psoriasis
  • senescence

IGFBP3[править]

Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients.


Keywords

  • CCL11
  • GDF11
  • IGF1
  • IGFBP
  • aging
  • pseudoxanthoma elasticum


Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3.


Keywords

  • IGFBP3
  • endocytosis
  • endometrial stem cells
  • paracrine senescence
  • secretome

IGFBP4[править]

Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Cognition
  • Female
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • Haplorhini
  • Humans
  • Insulin-Like Growth Factor Binding Protein 4
  • Male
  • Mice
  • Proteomics

Keywords

  • Cognitive dysfunction
  • IGFBP4
  • Plasma
  • Quantitative proteomics
  • iTRAQ

IGFBP7[править]

Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7.


Keywords

  • IGFBP7
  • IL-6
  • human fibroblast
  • osteoblast
  • reprogramming
  • senescence

IHH[править]

Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway.


Keywords

  • Indian hedgehog
  • aging
  • differentiation
  • mammalian target of rapamycin
  • mesenchymal stem cell

IL10[править]

The beneficial effect of physical exercise on inflammatory makers in older individuals.


Keywords

  • IL-6 expression
  • Inflammatory markers
  • aerobic exercise
  • aging
  • plasma IL-6 levels
  • resistance training


Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline.


MeSH Terms

  • Aged
  • Alternative Splicing
  • Astrocytes
  • Cells, Cultured
  • Cellular Senescence
  • Cognitive Dysfunction
  • Cytokines
  • Gene Expression
  • Glial Fibrillary Acidic Protein
  • Humans
  • Matrix Metalloproteinases
  • Transcription, Genetic
  • Tumor Suppressor Protein p14ARF
  • tau Proteins

Keywords

  • Alternative splicing
  • Gene expression
  • Neurodegenerative disease
  • Senescence


Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress.


MeSH Terms

  • Animals
  • Cognition Disorders
  • Encephalitis
  • Male
  • Mice
  • Oxidative Stress
  • Plasma
  • Swine

Keywords

  • aging
  • cognitive decline
  • dietary supplementation
  • neuroinflammation
  • spray-dried animal plasma

IL15[править]

Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of IL15.


Keywords

  • T cells
  • ageing
  • immune senescence
  • older people
  • physical activity

IL1A[править]

IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2.


Keywords

  • CCL2
  • cellular senescence
  • inflammaging
  • senescence-associated secretory phenotype

IL2[править]

Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus.


Keywords

  • IL2
  • aging
  • invariant natural killer T cells
  • thymus
  • transcriptome

IL6[править]

Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases.


MeSH Terms

  • Adaptive Immunity
  • Aged
  • Antirheumatic Agents
  • COVID-19
  • Comorbidity
  • Coronavirus Infections
  • Disease Outbreaks
  • Female
  • Humans
  • Hydroxychloroquine
  • Immunity, Innate
  • Immunologic Factors
  • Immunosuppressive Agents
  • Italy
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Rheumatic Diseases
  • Risk Assessment
  • Severe Acute Respiratory Syndrome

Keywords

  • COVID-19
  • SARS-CoV-2
  • geriatrics
  • pathophysiology
  • pediatrics
  • rheumatology


ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy.


Keywords

  • ATM
  • Ataxia-telangiectasia
  • Autophagy
  • Mitophagy
  • Neural progenitors
  • Oxidative stress
  • Senescence
  • hiPSCs


The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification.


Keywords

  • IL6
  • SASP
  • VSMCs
  • inflammaging
  • senescence
  • vascular calcification


Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung.


Keywords

  • Streptococcus pneumoniae
  • aging
  • influenza
  • vaccine effectiveness
  • viral immune imprinting


Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.


Keywords

  • Aging
  • Biomarker
  • Cognition
  • Neuropsychology


Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro.


MeSH Terms

  • Biliary Tract
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Cholestenones
  • Epithelial-Mesenchymal Transition
  • Histone Deacetylase 6
  • Humans
  • Interleukin-6
  • Signal Transduction
  • Stem Cells
  • Tissue Donors

Keywords

  • BMP pathway
  • SHH pathway
  • biliary tree stem/progenitor cells (BTSCs)
  • epithelial-to-mesenchymal transition (EMT)
  • primary sclerosing cholangitis (PSC)
  • senescence
  • telomerase


Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival.


MeSH Terms

  • Adipose Tissue, Brown
  • Animals
  • Cellular Senescence
  • Female
  • Longevity
  • Male
  • Mice
  • Ovarian Follicle
  • Ovary
  • Rats
  • Rats, Sprague-Dawley
  • Transplantation, Heterologous

Keywords

  • aging
  • brown adipose tissue (BAT)
  • lifespan
  • mice
  • ovary
  • rat
  • xenotransplant

ILDR1[править]

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.


MeSH Terms

  • Aging
  • Animals
  • Auditory Pathways
  • Female
  • Gene Expression Regulation
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Hearing Loss
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Molecular Sequence Annotation
  • Phenotype
  • Reproducibility of Results

IMPACT[править]

Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults.


Keywords

  • EEG
  • alpha oscillations
  • cognitive aging
  • working memory


Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-IMPACT Pilot.


Keywords

  • Telehealth
  • aging
  • care coordination
  • home care
  • interdisciplinary
  • medicine
  • older adult
  • video


AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY.


MeSH Terms

  • Aging
  • Autonomic Nervous System
  • Autonomic Nervous System Diseases
  • Female
  • Heart Rate
  • Humans
  • Male
  • Metabolic Diseases
  • Metabolism
  • Middle Aged
  • Obesity

Keywords

  • Aging
  • Autonomic nervous system
  • Heart rate
  • Obesity, metabolically benign
  • Parasympathetic nervous system
  • Sympathetic nervous system

INS[править]

Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity.


Keywords

  • Melatonin
  • Senescence
  • glucolipotoxicity
  • glucotoxicity
  • pancreatic β-cell


Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes.


MeSH Terms

  • Animals
  • Blotting, Western
  • Calcium
  • Cellular Senescence
  • Diabetes Mellitus, Type 2
  • Disease Progression
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Glucose
  • Insulin-Secreting Cells
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nicotine
  • Reactive Oxygen Species
  • Real-Time Polymerase Chain Reaction
  • beta-Galactosidase

Keywords

  • ROS
  • islet β cells
  • nicotine
  • senescence
  • type 2 diabetes

INSL3[править]

Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism.


Keywords

  • Androgen deficiency in aging male
  • arizona sexual experience scale
  • hypothyroidism
  • inhibin B
  • insulin-like factor 3
  • semen analysis
  • sperm motility

IP6K1[править]

The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.


Keywords

  • Akt
  • IP6K1
  • aging
  • anabolic resistance
  • mTOR
  • protein
  • resistance exercise
  • sarcopenia

IQGAP1[править]

IQGAP1-dysfunction leads to induction of senescence in human vascular smooth muscle cells.


Keywords

  • Cellular bridges (CBs)
  • IQGAP1
  • Intercellular communication
  • Senescence
  • Tunneling nanotubes (TNTs)
  • Vascular smooth muscle cells (VSMCs)


Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells.


Keywords

  • F-HABP07
  • HABP1
  • IQGAP1
  • senescence

IRF8[править]

IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function.


MeSH Terms

  • A549 Cells
  • Animals
  • Carcinogenesis
  • Carcinoma, Non-Small-Cell Lung
  • Cell Movement
  • Cell Proliferation
  • Cellular Senescence
  • Gene Expression Regulation, Neoplastic
  • Heterografts
  • Humans
  • Interferon Regulatory Factors
  • Mice
  • Prognosis
  • Signal Transduction
  • Tumor Suppressor Proteins

Keywords

  • IRF8
  • NSCLC
  • cell cycle arrest
  • cell senescence
  • tumor suppresser gene

IRS1[править]

MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle.


Keywords

  • CERK
  • aging muscle
  • insulin signaling pathway
  • miR-34a


Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.


Keywords

  • IGF
  • aging
  • autophagy
  • insulin
  • lifespan
  • metabolism
  • polyamine


Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Animals
  • Brain
  • Diabetes Mellitus, Type 2
  • Humans
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Male
  • Memory
  • Memory Disorders
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Phosphorylation
  • Serine
  • Signal Transduction

Keywords

  • AMPK
  • Alzheimer’s disease
  • Aβ
  • IRS1
  • aging
  • diabetes
  • energy depletion
  • hippocampus
  • memory decline
  • serine phosphorylation

IRS2[править]

Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells.


Keywords

  • IGF1
  • IGFBP3
  • INSR
  • IRS1
  • IRS2
  • Male reproduction
  • senescence

ITGA3[править]

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells.


Keywords

  • AKT
  • Culture-aged
  • ECM-receptor protein
  • Integrin α3
  • Senescence
  • Serial passaging
  • Tonsil-derived mesenchymal stem cells
  • Transcriptome

ITGA5[править]

Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes.


MeSH Terms

  • Animals
  • Blastocyst
  • Cellular Senescence
  • Embryo Culture Techniques
  • Embryo, Mammalian
  • Embryonic Development
  • Female
  • Integrins
  • Kaempferols
  • Mitochondria
  • Nanog Homeobox Protein
  • Octamer Transcription Factor-3
  • Oocytes
  • Oxidative Stress
  • RNA, Messenger
  • Reactive Oxygen Species
  • Swine

Keywords

  • embryonic development
  • kaempferol
  • oocyte aging
  • porcine

ITGAM[править]

Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging.


MeSH Terms

  • Aging
  • Animals
  • Disease Models, Animal
  • Epithelial Cells
  • Gingiva
  • Macaca mulatta
  • Oligonucleotide Array Sequence Analysis
  • Transcriptome

IVD[править]

MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology.


Keywords

  • ECM
  • MMP
  • annulus fibrosus
  • cartilaginous endplate
  • degenerative disc disease
  • miRNA
  • nucleus pulposus
  • senescence


A step-by-step protocol for isolation of murine nucleus pulposus cells.


Keywords

  • aging
  • gene expression
  • intervertebral disc degeneration
  • nucleus pulposus


Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging.


MeSH Terms

  • Aging
  • Animals
  • Annulus Fibrosus
  • Apoptosis
  • Biomarkers
  • Carcinogenesis
  • Caspase 3
  • Cell Count
  • Extracellular Matrix
  • Intervertebral Disc
  • Intervertebral Disc Degeneration
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nucleus Pulposus
  • Up-Regulation


Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.


MeSH Terms

  • Aging
  • Animals
  • Back Pain
  • Disease Models, Animal
  • Finite Element Analysis
  • Humans
  • Intervertebral Disc
  • Movement
  • Weight-Bearing
  • Zebrafish

Keywords

  • deformation
  • finite element
  • geometric morphometrics
  • mechanics
  • spine
  • zebrafish


Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM.


MeSH Terms

  • Adult
  • Age Factors
  • Aging
  • Analysis of Variance
  • Biomechanical Phenomena
  • Body Height
  • Body Mass Index
  • Body Weight
  • Cortical Bone
  • Female
  • Finite Element Analysis
  • Humans
  • Imaging, Three-Dimensional
  • Intervertebral Disc
  • Lumbar Vertebrae
  • Male
  • Models, Biological
  • Range of Motion, Articular
  • Risk Factors
  • Sex Characteristics

Keywords

  • Age
  • Biomechanics
  • Body mass index (BMI)
  • Finite element method (FEM)
  • Functional spinal unit (FSU)
  • Height
  • Response surface method (RSM)
  • Sex
  • Weight


In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs.


Keywords

  • Contrast‐enhanced microCT
  • aging
  • intervertebral disc
  • mouse model

JAK1[править]

Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling.


MeSH Terms

  • Bone Resorption
  • Cell Cycle Checkpoints
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • DNA Damage
  • Gene Expression Regulation, Developmental
  • Histones
  • Humans
  • Janus Kinase 1
  • Mesenchymal Stem Cells
  • Mitochondria
  • Osteogenesis
  • Paracrine Communication
  • Radiation
  • Reactive Oxygen Species
  • STAT3 Transcription Factor
  • Signal Transduction

Keywords

  • SASP
  • bone marrow mesenchymal stem cells
  • cellular senescence
  • irradiation
  • osteogenic differentiation


The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through JAK1.


MeSH Terms

  • Autocrine Communication
  • Cellular Senescence
  • Fetal Blood
  • Humans
  • Interleukin-6
  • Janus Kinase 1
  • Mesenchymal Stem Cells
  • Toll-Like Receptor 3
  • Up-Regulation

Keywords

  • Janus kinase 1 (JAK1)
  • Toll-like receptor 3 (TLR3)
  • interferon-β (IFN-β)
  • mesenchymal stromal cell (MSC)
  • senescence

JAK2[править]

Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity.


Keywords

  • DC-SIGN
  • IL-10
  • dengue virus
  • monocytes
  • senescence


Quercetin Directly Targets JAK2 and PKCδ and Prevents UV-Induced Photoaging in Human Skin.


MeSH Terms

  • Antioxidants
  • Cell Line
  • Cells, Cultured
  • Cyclooxygenase 2
  • Humans
  • Janus Kinase 2
  • MAP Kinase Signaling System
  • Matrix Metalloproteinase 1
  • NF-kappa B
  • Protein Kinase C-delta
  • Quercetin
  • STAT3 Transcription Factor
  • Skin
  • Skin Aging
  • Transcription Factor AP-1
  • Ultraviolet Rays

Keywords

  • JAK2
  • PKC-delta
  • quercetin
  • skin aging


[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera].


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breath Tests
  • Carbon Monoxide
  • Case-Control Studies
  • Erythrocyte Count
  • Erythrocytes
  • Female
  • Humans
  • Janus Kinase 2
  • Longevity
  • Male
  • Middle Aged
  • Polycythemia Vera

Keywords

  • Carbon monoxide breath test
  • Polycythemia vera
  • Red blood cell lifespan


Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation.


MeSH Terms

  • Aging
  • Animals
  • Hematopoiesis
  • Humans
  • Inflammation
  • Janus Kinase 2
  • Mice
  • Myeloproliferative Disorders
  • Neoplasms

Keywords

  • JAK2
  • Janus-kinase
  • aging
  • clonal hematopoiesis (CHIP), myeloproliferative neoplasia (MPN)

JUN[править]

Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.


MeSH Terms

  • Actin Cytoskeleton
  • Actins
  • Aging
  • Animals
  • Binding Sites
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Intercellular Junctions
  • Intestinal Mucosa
  • JNK Mitogen-Activated Protein Kinases
  • Phosphorylation
  • Protein Phosphatase 1
  • Transcription Factors
  • Troponin

Keywords

  • HSF-1
  • actin
  • aging
  • barrier
  • intestine
  • junctions
  • kinase
  • pathogenesis
  • phosphorylation
  • stress

JUNB[править]

Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.


MeSH Terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Gene Expression Regulation, Neoplastic
  • Gene Knockout Techniques
  • HEK293 Cells
  • Humans
  • Transcription Factors
  • Transcription, Genetic
  • Up-Regulation

Keywords

  • Cellular senescence
  • JUNB
  • P21(CDKN1A)
  • THG-1(TSC22D4)

KAT6B[править]

Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Epigenesis, Genetic
  • Erythroid Cells
  • Gene Expression Profiling
  • Gene Expression Regulation, Enzymologic
  • Gene Knockout Techniques
  • Histone Acetyltransferases
  • Male
  • Mice
  • Mice, Transgenic
  • Myeloid Progenitor Cells
  • Transcriptome

KCNK2[править]

Brain age prediction using deep learning uncovers associated sequence variants.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Brain
  • Databases, Factual
  • Deep Learning
  • Genome-Wide Association Study
  • Humans
  • Iceland
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neural Networks, Computer
  • Neuropsychological Tests
  • Polymorphism, Single Nucleotide
  • United Kingdom
  • Young Adult

KCNQ4[править]

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss.


Keywords

  • KCNQ4
  • PARP-1
  • aging
  • cGMP
  • guanylyl cyclase A
  • hidden hearing loss
  • inner ear
  • otoprotection

KCTD12[править]

The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort.


MeSH Terms

  • Adult
  • Demography
  • Female
  • Gene Expression Profiling
  • Humans
  • Longevity
  • Male
  • Metabolic Networks and Pathways
  • Middle Aged
  • Monocytes
  • Poverty
  • Transcriptome
  • Urban Population

KDM2A[править]

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.


Keywords

  • DNA repair
  • SIRT6
  • genome stability
  • longevity
  • transcription

KDM2B[править]

Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells.


Keywords

  • Lysine demethylase
  • Non-methylated CpG
  • Oncogene
  • Polycomb repressive complex
  • Replicative senescence
  • Zn-finger

KDM3A[править]

KDM3A and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization.


Keywords

  • Cell Biology
  • DNA damage
  • Molecular Mechanism of Gene Regulation
  • Stem Cells Research
  • bone aging
  • condensin
  • epigenetic regulation
  • histone demethylase
  • mesenchymal stromal cells

KEAP1[править]

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.


Keywords

  • Aging
  • KEAP1
  • Mouse
  • NRF2
  • Salivary glands


Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds.


MeSH Terms

  • Adaptation, Physiological
  • Animals
  • Antioxidants
  • Basal Metabolism
  • Biological Evolution
  • Birds
  • Cell Nucleus
  • Feathers
  • Fibroblasts
  • Genomics
  • Glutathione Transferase
  • HEK293 Cells
  • Humans
  • Kelch-Like ECH-Associated Protein 1
  • Longevity
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phylogeny
  • Proteasome Endopeptidase Complex
  • Protein Binding
  • Protein Transport
  • Ubiquitination
  • Up-Regulation

KIN[править]

The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Casein Kinase I
  • Heat-Shock Proteins, Small
  • Longevity
  • Malate Dehydrogenase
  • Peptides
  • Protein Aggregates
  • Protein Folding
  • RNA Interference
  • RNA, Small Interfering
  • Recombinant Proteins

Keywords

  • Caenorhabditis elegans (C. elegans)
  • chaperone
  • protein aggregates
  • protein aggregation
  • protein folding
  • proteostasis
  • selective protein aggregase
  • small heat shock protein (sHsp)

KIT[править]

Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.


Keywords

  • BMP15
  • C-KIT
  • GDF9
  • Ovarian aging
  • biomarkers

KLF2[править]

KLF2 induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21.


MeSH Terms

  • Animals
  • Carcinogenesis
  • Cell Cycle Proteins
  • Cell Line
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Forkhead Transcription Factors
  • Kruppel-Like Transcription Factors
  • Male
  • Mice
  • Mice, Nude
  • Pancreatic Neoplasms
  • Protein Binding
  • Up-Regulation

Keywords

  • FOXO4
  • KLF2
  • Pancreatic cancer
  • Senescence

KLF4[править]

Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation.


Keywords

  • aging
  • extracellular vesicles
  • oxygen
  • physiological oxygen concentration
  • physioxia
  • redox
  • senescence


Soluble klotho regulates the function of salivary glands by activating KLF4 pathways.


MeSH Terms

  • Animals
  • Cells, Cultured
  • Down-Regulation
  • Gene Expression Regulation
  • Glucuronidase
  • HEK293 Cells
  • Humans
  • Kruppel-Like Transcription Factors
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Nuclear Proteins
  • RNA Interference
  • RNA, Small Interfering
  • Salivary Glands

Keywords

  • KLF4
  • aging
  • salivary gland
  • soluble klotho

KLF6[править]

Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence.


Keywords

  • DNA damage
  • KLF6
  • cell proliferation
  • cellular senescence
  • ras oncogene

KRAS[править]

Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging.


Keywords

  • adenosine triphosphate
  • aging
  • antioxidant
  • apoptosis
  • atherogenesis
  • cancer
  • carcinogenesis
  • cholesterol
  • free radical
  • geraniol
  • geranylgeraniol
  • homocysteine
  • menoquinone
  • mitochondrial dysfunction
  • mitochondrial membrane potential
  • mitochondrial permeability transition pore
  • mitophagy
  • neuro-degeneration
  • oxidative phosphorylation
  • oxidative stress
  • squalene
  • statin
  • stellate cells
  • testosterone
  • thioretinaco ozonide
  • thioretinamide
  • tocopherol
  • tocotrienol
  • ubiquinone


Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.


MeSH Terms

  • Aging
  • Animals
  • CD8-Positive T-Lymphocytes
  • Carcinoma, Pancreatic Ductal
  • Cell Line, Tumor
  • Cell Proliferation
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinase 6
  • Gene Expression Regulation, Neoplastic
  • Genes, ras
  • Humans
  • Immunotherapy
  • MAP Kinase Signaling System
  • Mice
  • Pancreatic Neoplasms
  • Retinoblastoma Protein
  • Signal Transduction
  • Tumor Microenvironment
  • Vascular Remodeling

Keywords

  • T cells
  • chemotherapy resistance
  • endothelial cell activation
  • immunotherapy
  • pancreatic cancer
  • senescence
  • senescence-associated secretory phenotype
  • targeted therapy
  • tumor microenvironment
  • vascular biology

L1CAM[править]

Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression.


MeSH Terms

  • Adenosine Triphosphatases
  • Apoptosis
  • Biomarkers
  • Brain Neoplasms
  • Cation Transport Proteins
  • Cell Adhesion
  • Cell Adhesion Molecules, Neuronal
  • Cell Line, Tumor
  • Cellular Senescence
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Glioblastoma
  • Humans
  • Immunohistochemistry
  • Neural Cell Adhesion Molecule L1
  • RNA, Small Interfering
  • Signal Transduction

Keywords

  • AMOG
  • Apoptosis
  • Glioma
  • Human
  • L1CAM
  • Senescence
  • Therapy

LAG3[править]

T Cell Transcriptional Profiling and Immunophenotyping Uncover LAG3 as a Potential Significant Target of Immune Modulation in Multiple Myeloma.


Keywords

  • Autologous stem cell transplant
  • Exhaustion
  • LAG3
  • Multiple myeloma
  • Senescence

LAMP1[править]

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain.


Keywords

  • CLN3
  • TREM2
  • aging
  • autofluorescence
  • immunology
  • inflammation
  • lysosomal storage disorder
  • microglia
  • mouse
  • neuroscience
  • rhesus macaque

LBP[править]

Lipopolysaccharide binding protein is associated with CVD risk in older adults.


Keywords

  • Aging
  • Cardiovascular disease risk
  • Intestinal permeability
  • Lipopolysaccharide binding protein


Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels.


MeSH Terms

  • Acute-Phase Proteins
  • Aging
  • Animals
  • Apoptosis
  • Biomarkers
  • Carrier Proteins
  • Endotoxins
  • Female
  • Gene Expression Regulation
  • Glucose
  • Inflammation
  • Insulin Receptor Substrate Proteins
  • Liver
  • Liver Cirrhosis
  • Malate Dehydrogenase
  • Male
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Messenger
  • Receptor, Insulin
  • Toll-Like Receptor 4

Keywords

  • Tlr-4 signaling
  • aging
  • bacterial endotoxin
  • lipopolysaccharide binding protein
  • liver degeneration


Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations.


MeSH Terms

  • Aged
  • Aging
  • Biomarkers
  • Exercise Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Inflammation
  • Male
  • Metabolic Syndrome
  • Middle Aged
  • Mobility Limitation
  • Motor Activity
  • Obesity
  • Retrospective Studies
  • Weight Loss

Keywords

  • Ageing
  • Lipopolysaccharide-binding protein
  • Microbial translocation
  • Physical function


Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.


MeSH Terms

  • Aging
  • Amyloidogenic Proteins
  • Amyloidosis
  • Animals
  • Antigens, Surface
  • Female
  • Mammary Glands, Animal
  • Milk Proteins
  • Plaque, Amyloid
  • Rats
  • Rats, Sprague-Dawley

Keywords

  • Amyloidosis
  • lipopolysaccharide binding protein
  • mammary gland
  • pathology
  • rat


Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i].


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Drugs, Chinese Herbal
  • Receptors, Cytoplasmic and Nuclear

LBR[править]

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging.


Keywords

  • Aging
  • cancer
  • cellular senescence
  • chromatine structure
  • nuclear envelop


The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.


Keywords

  • Aneuploidy
  • Pregestational genetic testing
  • Reproductive aging
  • Single embryo transfer


The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).


Keywords

  • Gene expression
  • LBR
  • SAHF
  • SASP
  • Senescence


Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.


Keywords

  • LBR
  • autophagy
  • proteasome
  • protein accumulation
  • senescence
  • unbalanced growth

LEP[править]

Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan.


Keywords

  • Aging
  • Body mass index
  • Dynapenia
  • Leg extension power
  • Sarcopenia
  • Skeletal muscle


The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Composition
  • Cohort Studies
  • Cross-Sectional Studies
  • Denmark
  • Female
  • Hand Strength
  • Humans
  • Leg
  • Longevity
  • Middle Aged
  • Prospective Studies
  • Sarcopenia
  • Young Adult

Keywords

  • Body composition
  • DXA
  • Handgrip strength
  • Lean mass
  • Leg power
  • Sarcopenia

LGR6[править]

Effect of defensins-containing eye cream on periocular rhytids and skin quality.


Keywords

  • aging
  • defensins
  • periocular
  • rhytids
  • skin

LHCGR[править]

Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats.


Keywords

  • aging rats
  • diabetes mellitus
  • human chorionic gonadotropin
  • low-molecular-weight agonist
  • luteinizing hormone receptor
  • spermatogenesis
  • steroidogenesis
  • testes

LMNA[править]

Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.


Keywords

  • Inflammation and cellular senescence
  • Insulin resistance
  • LMNA/C transcript variants
  • Mononuclear cells
  • Type 2 diabetes mellitus


Protein structural and mechanistic basis of progeroid laminopathies.


Keywords

  • 3D structure
  • aging disorders
  • contact sites
  • lamin
  • nuclear structure


Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells.


Keywords

  • Hutchinson–Gilford progeria syndrome
  • LMNA
  • aging
  • atherosclerosis
  • endothelial dysfunction
  • inflammation
  • lamin A
  • prenylation
  • progerin


The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes.


Keywords

  • JAK/STAT pathway
  • cellular senescence
  • progeria
  • ruxolitinib


Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome.


Keywords

  • Aging
  • Extracellular vesicles
  • Hutchinson–Gilford progeria syndrome
  • Progerin
  • Stem cells
  • Therapeutics


Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models.


Keywords

  • Aging
  • Animal model breeding
  • Bone strength
  • Hutchinson-Gilford Progeria Syndrome (HGPS)
  • Kyphosis
  • Quality of life

LMNB1[править]

SIRT1 - a new mammalian substrate of nuclear autophagy.


Keywords

  • Aging
  • SIRT1
  • nuclear autophagy
  • senescence
  • sirtuin


Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells.


Keywords

  • alpha tubulin
  • cellular senescence
  • mesothelial cells
  • microarray analysis
  • multiwalled carbon nanotubes
  • γH2A.X


Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.


Keywords

  • aging
  • cardiovascular
  • inflammation
  • senescence
  • smooth muscle cell

LOX[править]

12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout.


Keywords

  • 2-arachidonoyl-lysophospholipids
  • aging
  • calcium
  • eicosanoid
  • iPLA2γ
  • lysophospholipid
  • myocardium
  • platelet
  • platelet-type 12-lipoxygenase (12-LOX)
  • polyunsaturated fatty acids (PUFAs)

LOXL1[править]

A blackberry-dill extract combination synergistically increases skin elasticity.


Keywords

  • blackberry-dill
  • elasticity
  • skin aging
  • skin physiology/structure
  • skin repair

LOXL2[править]

Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.


MeSH Terms

  • Adenoviridae
  • Aging
  • Amino Acid Oxidoreductases
  • Animals
  • Arthritis, Experimental
  • Cartilage, Articular
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression
  • Gene Transfer Techniques
  • Genetic Vectors
  • Interleukin-1beta
  • Mice
  • Mice, Transgenic
  • NF-kappa B
  • Osteoarthritis, Knee
  • Transduction, Genetic

Keywords

  • Lysyl oxidase like-2
  • adenovirus delivery
  • anabolic response
  • articular cartilage
  • knee joint
  • osteoarthritis
  • regeneration

LPA[править]

Ginseng gintonin, aging societies, and geriatric brain diseases.


Keywords

  • Brain aging
  • Gintonin
  • Neurodegenerative diseases
  • Panax ginseng
  • Rejuvenation


Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty.


Keywords

  • cognitive aging
  • depression
  • frailty


Does sedentary time increase in older adults in the days following participation in intense exercise?


MeSH Terms

  • Accelerometry
  • Aged
  • Exercise
  • Exercise Test
  • Humans
  • Sedentary Behavior
  • Sleep

Keywords

  • Aging
  • Compensation
  • High intensity
  • Movement behaviours


Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.


MeSH Terms

  • Aged
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lipoprotein(a)
  • Longevity
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Parents
  • Phenotype
  • Prospective Studies
  • Risk Factors


Elevated Autotaxin and LPA Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation.


Keywords

  • Aging
  • Autotaxin
  • Hepatitis
  • Hepatocellular Carcinoma
  • Immune Activation
  • Immunity
  • Inflammation
  • Liver
  • Lysophosphatidic Acid


Lysophosphatidic acid receptor LPA prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome.


Keywords

  • 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate
  • Hutchinson-Gilford progeria syndrome
  • LPA3
  • cell senescence
  • lysophosphatidic acid
  • reactive oxygen species


Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study.


Keywords

  • accelerometry
  • aging
  • exercise
  • neurocognitive disorders
  • sedentary lifestyle


Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin.


Keywords

  • White matter hyperintensity
  • brain aging
  • cerebral small vessel disease
  • lesion segmentation
  • methodology
  • validation


The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study.


MeSH Terms

  • Accelerometry
  • Aged
  • Aged, 80 and over
  • Aging
  • Body Mass Index
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Humans
  • Male
  • Physical Fitness
  • Sedentary Behavior

Keywords

  • accelerometry
  • ageing
  • health
  • physical fitness
  • sedentary behaviour


Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality.


MeSH Terms

  • Aged
  • Cardiovascular Diseases
  • Cohort Studies
  • Exercise
  • Female
  • Follow-Up Studies
  • Humans
  • Leisure Activities
  • Male
  • Middle Aged
  • Mortality
  • Neoplasms
  • Proportional Hazards Models
  • Prospective Studies
  • Respiratory Tract Diseases
  • Risk Factors
  • Surveys and Questionnaires
  • United States

Keywords

  • Aging
  • Cancer prevention study
  • Leisure time physical activity
  • Light-intensity physical activity

LPL[править]

Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects.


Keywords

  • SNP effect
  • Weibull hazards model
  • genetic parameter
  • health disorder
  • longevity


Influence of common health disorders on the length of productive life and stayability in German Holstein cows.


MeSH Terms

  • Animals
  • Breeding
  • Cattle
  • Cattle Diseases
  • Dairying
  • Farmers
  • Female
  • Lactation
  • Longevity
  • Phenotype

Keywords

  • genetic parameter
  • health disorder
  • longevity
  • subjective culling reason

LPO[править]

[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.]


MeSH Terms

  • Aging
  • Animals
  • Brain Ischemia
  • Disease Models, Animal
  • Lipid Peroxidation
  • Rats
  • Reperfusion Injury
  • Sodium-Potassium-Exchanging ATPase

Keywords

  • Na+/K+-ATPase
  • aging
  • brain
  • lipid peroxidation
  • oxidative stress
  • stroke

LRP1[править]

Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.


MeSH Terms

  • Animals
  • Atherosclerosis
  • Cellular Senescence
  • Diet, Western
  • Disease Models, Animal
  • Indoleacetic Acids
  • Macrophages
  • Metabolic Syndrome
  • Mice
  • Mice, Knockout
  • Obesity
  • Plaque, Atherosclerotic
  • Plasminogen Activator Inhibitor 1
  • Receptors, LDL

Keywords

  • atherosclerosis
  • cellular senescence
  • fibrinolysis
  • metabolic syndrome
  • muscle, smooth
  • obesity
  • plasminogen activator inhibitor-1

LRP4[править]

Multiple MuSK signaling pathways and the aging neuromuscular junction.


Keywords

  • Aging
  • BMP signaling
  • MuSK
  • Neuromuscular junction
  • Synaptic maintenance

LRP6[править]

Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities.


MeSH Terms

  • Aging
  • Animals
  • Cardiovascular Diseases
  • Humans
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Muscle, Smooth, Vascular
  • Myocytes, Smooth Muscle
  • Obesity
  • Signal Transduction
  • Structure-Activity Relationship
  • Vascular Calcification
  • Wnt Signaling Pathway

LRRK2[править]

Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease.


Keywords

  • LRRK2 variants
  • Parkinson’s disease
  • aging
  • telomere length


The effect of LRRK2 loss-of-function variants in humans.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Specimen Banks
  • Cell Line
  • Embryonic Stem Cells
  • Female
  • Gain of Function Mutation
  • Heterozygote
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Longevity
  • Loss of Function Mutation
  • Lymphocytes
  • Male
  • Middle Aged
  • Myocytes, Cardiac
  • Parkinson Disease
  • Phenotype


Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.


Keywords

  • And aging
  • Dendritic hypotrophy
  • Excitability
  • G2019S
  • GABAA
  • LRRK2
  • Nuclear DNA damage
  • Nuclear hypertrophy
  • Nuclear invagination
  • Parkinson’s disease
  • R1441C
  • Striatal spiny projection neuron


Autophagy and LRRK2 in the Aging Brain.


Keywords

  • LAMP2A
  • LC3
  • LRRK2
  • Parkinson’s disease
  • aging
  • autophagy
  • lysosomes
  • α-synuclein

LSS[править]

Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia.


Keywords

  • aging
  • elderly person
  • gait speed
  • lumbar spinal stenosis
  • lumbar spine
  • muscle strength
  • sarcopenia
  • skeletal muscle mass
  • surgical result


Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Delivery of Health Care, Integrated
  • Geriatrics
  • Hip Fractures
  • Hospitals, Teaching
  • Humans
  • Ireland
  • Length of Stay
  • Nerve Block
  • Orthopedics
  • Pain Management
  • Total Quality Management
  • Treatment Outcome

Keywords

  • Lean Six Sigma
  • healthcare outcomes
  • hip fracture care
  • integrated care pathways
  • interdisciplinary working
  • process improvement

LTA[править]

Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice.


Keywords

  • Aging
  • Cell wall
  • Cognition
  • Goblet cell
  • Inflammation
  • Leaky gut
  • Lipoteichoic acid
  • Metabolism
  • Mucin
  • Physical function
  • Probiotics


The change of pain classes over time: a latent transition analysis.


MeSH Terms

  • Aged
  • Aging
  • Humans
  • Life Style
  • Longitudinal Studies
  • Middle Aged
  • Pain
  • Quality of Life

LY6D[править]

LY6D-induced macropinocytosis as a survival mechanism of senescent cells.


Keywords

  • LY6D
  • Ras protein
  • cellular senescence
  • endocytosis
  • lipid raft
  • macropinocytosis
  • vacuole

MAG[править]

Exploration of life satisfaction of Korean people with sensory impairments across the lifespan.


Keywords

  • Across the lifespan
  • Leisure domain
  • Life satisfaction
  • Sensory impairment
  • Social domain

MALT1[править]

MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity.


MeSH Terms

  • Animals
  • Behavior, Animal
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Gene Expression Regulation
  • Green Fluorescent Proteins
  • Immunity
  • Interleukin-17
  • Interneurons
  • Longevity
  • Models, Biological
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Neurons
  • Oxygen
  • Signal Transduction
  • Subcellular Fractions
  • Transgenes


MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging.


MeSH Terms

  • Age Factors
  • Animals
  • CTLA-4 Antigen
  • Cytokines
  • Dermatitis, Atopic
  • Disease Models, Animal
  • Disease Susceptibility
  • Gene Expression
  • Genetic Predisposition to Disease
  • Immunoglobulin E
  • Lymphocyte Activation
  • Mice
  • Mice, Knockout
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
  • Skin
  • T-Lymphocyte Subsets

Keywords

  • MALT1
  • Th2
  • Tregs
  • aging
  • atopic dermatitis
  • lymphocytes
  • skin inflammation

MAP2[править]

Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent.


Keywords

  • aging
  • diffusion tensor imaging
  • immunohistochemistry
  • ischemic preconditioning

MAP4K3[править]

MAP4K3/GLK in autoimmune disease, cancer and aging.


MeSH Terms

  • Aging
  • Autoimmune Diseases
  • Humans
  • Neoplasms
  • Protein-Serine-Threonine Kinases

Keywords

  • Aging
  • Autoimmune disease
  • Autophagy
  • Cancer metastasis
  • HPK1
  • IL-17A
  • IQGAP1
  • MAP4K3 (GLK)
  • PKCθ
  • Verteporfin

MAPK1[править]

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1.


Keywords

  • MAPK1
  • VB1
  • purified vitexin compound 1
  • senescence
  • skin photoaging

MAPKAPK2[править]

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks.


MeSH Terms

  • AMP-Activated Protein Kinases
  • Animals
  • Calcium
  • Cell Line
  • Endocytosis
  • HEK293 Cells
  • Homeostasis
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Liver
  • Metformin
  • Mice
  • Phosphorylation
  • Protein Kinase C
  • Protein-Serine-Threonine Kinases
  • Proteomics
  • Signal Transduction

Keywords

  • AMPK3
  • LKB1
  • PKD1
  • STIM1
  • aging
  • calcium
  • diabetes
  • kinases
  • liver
  • metformin

MAPT[править]

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alcohol Drinking
  • Biological Specimen Banks
  • Brain
  • Cognition
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuroimaging
  • Polymorphism, Single Nucleotide
  • Smoking
  • United Kingdom
  • tau Proteins


A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial.


Keywords

  • Aging
  • Biomarkers of diet quality
  • Cognitive decline
  • DHA
  • EPA
  • Elderly
  • Homocysteine
  • Metabolomics
  • Nutrient biomarkers
  • Omega-3 fatty acids
  • Vitamin D


Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Body Composition
  • Brain
  • Cognition
  • Exercise
  • Female
  • Humans
  • Longitudinal Studies
  • Male

Keywords

  • Aging
  • Biomarkers
  • Phenotype
  • Physical activity


Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Amyloidosis
  • Animals
  • Disease Models, Animal
  • Mice
  • Mice, Transgenic
  • tau Proteins


Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.


Keywords

  • Alzheimer’s disease
  • Ferroptosis
  • Iron
  • Reactive oxygen species
  • Senescence
  • Tau

MATN3[править]

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.


MeSH Terms

  • Aging
  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Chondrocytes
  • Disease Models, Animal
  • Female
  • Gene Knockout Techniques
  • Humans
  • Male
  • Matrilin Proteins
  • Mice
  • Mice, Knockout
  • Microscopy, Atomic Force
  • Muscle, Skeletal
  • Osteoarthritis

Keywords

  • articular cartilage
  • bone development
  • cartilage
  • matrilin
  • osteoarthritis

MB[править]

Probing menstrual bloodstain aging with fluorescence spectroscopy.


Keywords

  • Aging
  • Analytical methods
  • Blood
  • Fluorescence spectroscopy
  • Forensics


Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cognition
  • Cross-Sectional Studies
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Vascular Diseases

Keywords

  • active aging
  • cognitive preservation
  • exercise habit
  • lifestyle advice
  • vascular care


A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells.


MeSH Terms

  • Antineoplastic Agents
  • Breast Neoplasms
  • Catalysis
  • Cell Line, Tumor
  • Cell Survival
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Down-Regulation
  • Female
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Palladium
  • Sulfonamides
  • Survivin
  • Tumor Suppressor Protein p53
  • Up-Regulation

Keywords

  • Cell cycle arrest
  • Novel indenone derivative
  • Senescence
  • Triple-negative breast cancer


Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells.


Keywords

  • DNA damage
  • Rubicon
  • SQSTM1/p62
  • TFEB
  • autophagic index
  • autophagy
  • cancer
  • polyploidy
  • senescence
  • senescence escape


Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.


Keywords

  • Drosophila
  • Rab27
  • S6K
  • TOR
  • lifespan extension
  • mushroom body


Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells.


Keywords

  • apoptosis
  • cancer stem-like cells
  • doxorubicin
  • magnetic iron oxide nanoparticles
  • mitotic catastrophe
  • senescence


"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.


Keywords

  • ALT
  • SQSTM1/p62
  • amoeboid conversion
  • budding of mitotic progeny
  • cellular senescence
  • extranuclear DNA
  • genotoxic treatment
  • inverted meiosis
  • mtTP53 cancer
  • polyploidization


Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.


MeSH Terms

  • Antineoplastic Agents
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Doxorubicin
  • Fluorouracil
  • Humans
  • Irinotecan
  • Methotrexate
  • Neoplasms
  • Oxaliplatin
  • Paclitaxel
  • Phenotype
  • Tumor Cells, Cultured

Keywords

  • DNA damage
  • SASP
  • cancer
  • chemotherapy
  • senescence
  • senescence markers


Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax.


Keywords

Spalax

  • DNA damage
  • DNA repair
  • cellular senescence
  • interleukin-1 alpha (IL1α)
  • nuclear factor κB (NF-κB)
  • senescence-associated secretory phenotype (SASP)


Quantification of the health-status of the Dutch Labrador retriever population.


MeSH Terms

  • Animals
  • Dog Diseases
  • Dogs
  • Female
  • Health Status
  • Insurance
  • Laboratories
  • Longevity
  • Male
  • Netherlands
  • Proportional Hazards Models
  • Risk Factors

Keywords

  • Canine health
  • Data analysis
  • Health parameters
  • Labrador retriever
  • Lifespan
  • Oncology


Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.


MeSH Terms

  • ATP-Binding Cassette Transporters
  • Breast Neoplasms
  • Cell Cycle Checkpoints
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p21
  • Female
  • Glucuronides
  • Humans
  • MCF-7 Cells
  • Resveratrol
  • Retinoblastoma Protein
  • Signal Transduction
  • Stilbenes
  • Tumor Suppressor Protein p53

Keywords

  • ABC transporters
  • breast cancer
  • deconjugation
  • resveratrol metabolites
  • senescence

MBP[править]

Demyelination associated with chronic arsenic exposure in Wistar rats.


MeSH Terms

  • Aging
  • Amyloid beta-Protein Precursor
  • Animals
  • Arsenic Poisoning
  • Arsenites
  • Axons
  • Corpus Callosum
  • Demyelinating Diseases
  • Diffusion Tensor Imaging
  • Drinking Water
  • Immunohistochemistry
  • Male
  • Mitochondria
  • Myelin Basic Protein
  • Neurofilament Proteins
  • Prefrontal Cortex
  • Rats
  • Rats, Wistar
  • Sodium Compounds
  • White Matter

Keywords

  • Amyloid
  • Anisotropy
  • Arsenic
  • Axonal damage
  • DTI
  • Demyelination
  • Development
  • MRI
  • Microstructure
  • Mitochondria


Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain.


Keywords

  • EAE
  • NK cells
  • aging
  • dendritic cells
  • strain differences

MCC[править]

Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS).


Keywords

  • Aging
  • and memory study
  • cognitive impairment with no dementia
  • dementia
  • demographics
  • multimorbidity
  • multiple chronic conditions


Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity.


Keywords

  • Aging
  • Behaviour consistency
  • Heart rate
  • Physical activity
  • Treadmill running


Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life.


Keywords

  • aging
  • analyse d’intersectionnalité
  • caregiver burden
  • fardeau de l’aidant
  • gender
  • interférence sociale
  • intersectionality analysis
  • maladies chroniques multiples
  • multiple chronic conditions
  • sexe
  • social interference
  • vieillissement

MCM9[править]

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Bone Marrow
  • Cell Differentiation
  • Cell Proliferation
  • DNA Damage
  • Gene Expression Regulation, Leukemic
  • Hematologic Neoplasms
  • Mice
  • Mice, Knockout
  • Minichromosome Maintenance Proteins
  • Retinoblastoma Protein
  • Signal Transduction
  • Splenomegaly
  • Tumor Suppressor Protein p53

Keywords

  • DNA damage
  • DNA repair
  • MCM8
  • MCM9
  • cancer
  • hematopoiesis
  • homologous recombination
  • myelodysplastic syndrome

MCU[править]

A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report.


MeSH Terms

  • Aged, 80 and over
  • Colon, Transverse
  • Epstein-Barr Virus Infections
  • Herpesvirus 4, Human
  • Humans
  • Intestinal Mucosa
  • Intestinal Obstruction
  • Male
  • Ulcer

Keywords

  • Aging
  • Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU)
  • Immunosuppression
  • Intestinal obstruction
  • Surgical resection


Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue.


MeSH Terms

  • Adipocytes, Brown
  • Adipose Tissue, Brown
  • Aging
  • Animals
  • Calcium
  • Capsaicin
  • Gene Expression Regulation
  • Mice
  • Mice, Knockout
  • Mitochondria
  • Obesity
  • Sirtuin 3

MDH1[править]

Oxidative Damage to the TCA Cycle Enzyme MDH1 Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain.


Keywords

  • DPM
  • MRM
  • TCA cycle
  • aging
  • brain

MDM2[править]

SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Cyclin-Dependent Kinase Inhibitor p21
  • Gene Expression Regulation, Neoplastic
  • HCT116 Cells
  • Heterografts
  • Histone Deacetylases
  • Humans
  • Mice
  • Neoplasms
  • Protein Binding
  • RNA, Long Noncoding
  • Signal Transduction
  • Tumor Suppressor Protein p53


Disruption of Robo2-Baiap2 integrated signaling drives cystic disease.


MeSH Terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Cellular Senescence
  • Cilia
  • Disease Models, Animal
  • Epithelial Cells
  • Humans
  • Kidney
  • Kidney Diseases, Cystic
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins
  • Protein Binding
  • Protein Domains
  • Receptors, Immunologic
  • Signal Transduction
  • Tumor Suppressor Protein p53

Keywords

  • Cellular senescence
  • Development
  • Genetic diseases
  • Nephrology
  • Signal transduction


Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes.


MeSH Terms

  • Amniocentesis
  • Amnion
  • Biomarkers
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Electrophysiological Phenomena
  • Female
  • Gene Expression Regulation
  • Humans
  • Immunophenotyping
  • Phenotype

Keywords

  • amniocyte
  • automated patch-clamp
  • flow cytometry
  • mesenchymal stem cell
  • qRT-PCR
  • replicative senescence
  • senescence-associated secretory phenotype

MED25[править]

The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i].


Keywords

  • ERF022
  • H3K9ac
  • HAC1
  • Mediator complex
  • histone acetylation
  • leaf senescence

MEFV[править]

The grandfather's fever.


MeSH Terms

  • Age of Onset
  • Aged, 80 and over
  • Familial Mediterranean Fever
  • Female
  • Humans
  • Male
  • Pedigree
  • Pyrin

Keywords

  • Autoinflammatory diseases
  • FMF
  • Genetics
  • Geriatrics
  • Periodic fever

MEOX2[править]

Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization.


Keywords

  • aging
  • angiogenesis
  • microRNA
  • neovascularization
  • senescence

MET[править]

Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors.


Keywords

  • Cancer survivorship
  • Epidemiology
  • Fruit and vegetable
  • Gerontology
  • Physical activity


Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study.


Keywords

  • exercise
  • healthy aging
  • physical activity
  • retirement
  • successful aging


Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i].


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Heterochromatin
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Inheritance Patterns
  • Jumonji Domain-Containing Histone Demethylases
  • Longevity
  • Lysine
  • Methylation
  • Mutation

Keywords

  • C. elegans
  • COMPASS
  • aging
  • chromatin
  • chromosomes
  • epigenetics
  • gene expression
  • genetics
  • genomics
  • heterochromatin
  • transgenerational inheritance


Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study.


Keywords

  • aging
  • cadence
  • physical activity intensity
  • public health
  • walking

MFI[править]

The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement.


Keywords

  • HDPE
  • accelerated aging tests
  • decrease mechanical properties
  • degradation
  • geosynthetics
  • landfill
  • polyolefin


Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging.


Keywords

  • aging
  • beef muscle
  • microstructure
  • myofibril fragmentation
  • protein solubility


Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging.


MeSH Terms

  • Animals
  • Cattle
  • Cold Temperature
  • Electric Stimulation
  • Food Handling
  • Food Quality
  • Food Storage
  • Hydrogen-Ion Concentration
  • Male
  • Meat
  • Muscle, Skeletal
  • Polysaccharides
  • Postmortem Changes
  • Time Factors

Keywords

  • Yak
  • electrical stimulation
  • postmortem aging
  • tenderness


Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef.


Keywords

  • Beef Loin
  • Digestibility
  • Dry Aging
  • Shear Force
  • Wet Aging

MFN2[править]

Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice.


Keywords

  • aging
  • heart
  • ischemia-reperfusion
  • mitochondria
  • thioredoxin


MFN2 contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis.


Keywords

  • Aging
  • Inflammation
  • MFN2
  • Metabolic disorders
  • Osteoarthritis

MFSD2A[править]

Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease.


MeSH Terms

  • Aged
  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Fatty Acids
  • Female
  • Humans
  • Male
  • Symporters

Keywords

  • Alzheimer’s disease
  • MFSD2a carrier
  • aging
  • neurologic disorders
  • omega-3 PUFA

MGMT[править]

Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.


Keywords

  • apoptosis
  • cancer therapy
  • drug resistance
  • glioblastoma
  • methadone
  • senescence
  • temozolomide

MIA[править]

Age, cohort, and period effects on metamemory beliefs.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Cross-Sectional Studies
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Metacognition
  • Middle Aged


Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety.


MeSH Terms

  • Aged
  • Aging
  • Anxiety
  • Female
  • Humans
  • Internal-External Control
  • Male
  • Memory, Episodic
  • Metacognition
  • Middle Aged
  • Stereotyping

MIB1[править]

Immunohistochemical detection of senescence markers in human sarcomas.


Keywords

  • SenTraGor
  • Senescence
  • p16
  • p21
  • sarcoma

MIP[править]

Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women.


Keywords

  • Aging
  • Cardiac output
  • Center-of-pressure
  • Middle cerebral artery blood flow velocity
  • Respiratory muscles


A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study.


Keywords

  • Aging
  • Amino acids
  • Cytokines
  • Metabolomics
  • Neurodegeneration
  • Personalized medicine


Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning.


Keywords

  • Brain aging
  • Chemokines
  • Cognitive aging
  • Exercise
  • Gender
  • Inflammation
  • Lifestyle


Comparison of balance changes after inspiratory muscle or Otago exercise training.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Breathing Exercises
  • Exercise
  • Exercise Therapy
  • Female
  • Humans
  • Male
  • Maximal Respiratory Pressures
  • Muscle Strength
  • Physical Endurance
  • Postural Balance
  • Respiratory Muscles
  • Respiratory Therapy

MITF[править]

Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.


Keywords

  • Nigella sativa
  • Thymocid®
  • black cumin
  • collagen
  • collagenase
  • cosmeceutical
  • elastase
  • glycation
  • melanogenesis
  • skin aging


HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth.


Keywords

  • HuR
  • MITF
  • Microphthalmia-associated transcription factor
  • malignant melanoma
  • oncogene induced senescence

MLH1[править]

The somatic mutation landscape of the human body.


MeSH Terms

  • Age Factors
  • Aging
  • Humans
  • Mutation
  • Neoplasms
  • Selection, Genetic
  • Sex Factors

Keywords

  • Aging
  • Cancer
  • Genomic instability
  • Human
  • Somatic evolution
  • Somatic mutation

MLKL[править]

Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i].


Keywords

  • cardiomyocytes
  • hypoxia
  • necroptosis
  • remifentanil
  • senescence

MLN[править]

Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.


Keywords

  • RALDH2
  • aging
  • dendritic cells
  • epigenetic regulation
  • regulatory T cells
  • retinoic acid

MMD[править]

Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.


Keywords

  • LIFE Study
  • deficit accumulation
  • disability
  • frailty
  • healthy aging
  • mobility
  • older adults


Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.


Keywords

  • anticholinergic burden
  • falls
  • mobility
  • physical activity
  • successful aging


Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.


Keywords

  • aging
  • mobility disability
  • multicenter trialphysical activity

MME[править]

Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes.


Keywords

  • aging
  • older adults
  • opioid harm reduction
  • overdose risk


Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid
  • Anesthetics, Local
  • Delirium
  • Female
  • Femoral Fractures
  • Fracture Fixation, Internal
  • Geriatrics
  • Humans
  • Injections, Intra-Articular
  • Intraoperative Care
  • Male
  • Pain Management
  • Pain, Postoperative
  • Retrospective Studies

Keywords

  • Geriatrics
  • Hip fracture
  • Local anesthetic
  • Narcotics

MMP1[править]

Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts.


Keywords

  • Cell shape
  • Fibroblast
  • Lithography
  • SASP
  • Senescence


A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes.


Keywords

  • anti-wrinkle
  • pigmentation
  • pollution
  • skin aging
  • skin barrier

MMP13[править]

Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis.


MeSH Terms

  • Aging
  • Animals
  • Antigens, Differentiation
  • Chondrocytes
  • Chondrogenesis
  • Core Binding Factor Alpha 1 Subunit
  • Fetal Proteins
  • Gene Expression Regulation
  • Intervertebral Disc Degeneration
  • Mice
  • Mice, Transgenic
  • Sp7 Transcription Factor
  • T-Box Domain Proteins

Keywords

  • Wnt/β-catenin/LRPs
  • biomechanics
  • genetic animal models
  • osterix

MOS[править]

Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador.


MeSH Terms

  • Actinobacteria
  • Aeromonas
  • Animal Feed
  • Animals
  • Aquaculture
  • Bacterial Adhesion
  • Ecuador
  • Flavobacteriaceae
  • Lactococcus
  • Longevity
  • Mannans
  • Microbiota
  • Oligosaccharides
  • Penaeidae
  • Proteobacteria
  • Seafood
  • Shewanella
  • Verrucomicrobia
  • Vibrio


Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys.


Keywords

  • Chiang Mai
  • HIV and aging
  • Older adults living with HIV
  • Thailand
  • health-related quality of life
  • quality of life


Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Aging
  • China
  • Cross-Sectional Studies
  • Ethnic Groups
  • Female
  • Humans
  • Male
  • Middle Aged
  • Quality of Life

Keywords

  • ADL
  • Elderly
  • Health-related quality of life
  • IADL
  • Yi ethnic minority


Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino.


MeSH Terms

  • Animal Feed
  • Animals
  • Antioxidants
  • Diet
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Gastropoda
  • Immunity, Innate
  • Longevity
  • Mannans
  • Oligosaccharides
  • Vibrio parahaemolyticus

Keywords

  • Abalone
  • Antioxidation
  • Bacterial challenge
  • Disease resistance
  • Growth
  • Immunity
  • Mannan oligosaccharide

MPHOSPH6[править]

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.


MeSH Terms

  • Genome-Wide Association Study
  • Humans
  • Leukocytes
  • Nucleotides
  • Telomere

Keywords

  • Mendelian randomisation
  • age-related disease
  • biological aging
  • telomere length

MPI[править]

Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study.


Keywords

  • Age-related
  • Aging
  • Aqueous humor
  • Drainage
  • Eye
  • Glaucoma
  • Imaging
  • In vivo
  • Lymph node
  • Lymphatic
  • Mice
  • Photoacoustic tomography
  • Uveoscleral


Interest of the multidimensional prognostic index (MPI) as an assessment tool in hospitalized patients in geriatrics.


MeSH Terms

  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Length of Stay
  • Male
  • Patient Readmission
  • Prognosis

Keywords

  • elderly
  • geriatrics
  • hospitalization
  • multidimensional prognostic index

MRE11[править]

Chromosomal alterations among age-related haematopoietic clones in Japan.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Alleles
  • Cell Lineage
  • Chromosome Aberrations
  • Chromosomes, Human
  • Clone Cells
  • Cohort Studies
  • Female
  • Genetic Loci
  • Genome, Human
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Japan
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Leukemia, T-Cell
  • Male
  • Mosaicism
  • Mutation
  • United Kingdom

MSC[править]

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.


Keywords

  • BM, bone marrow
  • CVD, cardiovascular disease
  • EC, endothelial cell
  • EPC, endothelial progenitor cell
  • EV, extracellular vesicle
  • FBS, fetal bovine serum
  • MEM, minimum essential medium
  • MI, myocardial infarction
  • MSC, mesenchymal stromal cell
  • NTA, nanotracking analysis
  • PBS, phosphate-buffered saline
  • TEV, tailored extracellular vesicle
  • VEGF, vascular endothelial growth factor
  • acellular
  • angiogenesis
  • extracellular vesicles
  • lin− BMC, lineage negative bone marrow cell
  • miR, microRNA
  • qPCR, quantitative transcription polymerase chain reaction
  • regeneration
  • senescence


Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.


Keywords

  • Aging
  • Cortical injury
  • Extracellular vesicles
  • Monkeys
  • Myelin
  • Non-human primates
  • Oligodendrocytes
  • Stroke
  • White matter


TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.


Keywords

  • DNA repair
  • aging
  • myocardial infarction
  • stem cells therapy
  • telomere


Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.


Keywords

  • aging
  • bone resorption
  • immunomodulation
  • mesenchymal stem cell
  • periodontitis
  • tissue destruction


Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.


Keywords

  • Aging
  • Follicular development
  • Hormone biosynthesis
  • Primordial follicle activation
  • Stem cell therapy
  • miR-145


Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.


Keywords

  • adult stem cells
  • aging
  • mesenchymal stromal cells (MSC)
  • regenerative medicine
  • stem cell niche


The biology of human hair greying.


Keywords

  • ageing
  • endocrine
  • graying
  • melanin
  • senescence


[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.


Keywords

  • TSC1
  • mammalian target of rapamycin (mTOR)
  • mesenchymal stem cell
  • senescence
  • stem cell proliferation
  • tuberous sclerosis


The role of mitochondrial dysfunction in mesenchymal stem cell senescence.


Keywords

  • Mesenchymal stem cells
  • Mitochondrial dysfunction
  • Mitophagy
  • Reactive oxygen species
  • Senescence


Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.


Keywords

  • EV
  • MSC
  • Metabolic syndrome
  • RNA-sequencing
  • Senescence


Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.


Keywords

  • Aging diseases
  • Conditioned medium
  • Diabetes
  • Exosomes
  • Extracellular vesicles
  • Lupus
  • Regenerative medicine
  • Secretome


Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs.


Keywords

  • Aging
  • Heterochromatin
  • MSC senescence
  • mTORC1/p70S6K


Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.


Keywords

  • cellular senescence
  • exosomes
  • kidney
  • mesenchymal stem cells
  • renal artery obstruction


Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.


Keywords

  • aging
  • bone marrow
  • mesenchymal stromal cells
  • senescence
  • type 1 interferon


Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.


Keywords

  • amniotic fluid stem cells products
  • dermaroller
  • facial aging
  • skin needling


Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.


Keywords

  • autophagy
  • mesenchymal stem cells
  • mitochondrial
  • rejuvenation
  • senescence
  • telomere


The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.


Keywords

  • Aging
  • DNA methylation
  • Epigenetics
  • Histome modifications
  • MSC
  • Mesenchymal Stem/Stromal Cells
  • Skeleton
  • miRNA


Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.


Keywords

  • SASP
  • general autophagy
  • mesenchymal stem cell
  • selective autophagy
  • senescence


Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.


Keywords

  • adipose-derived stromal/stem cell
  • aging
  • gene expression
  • long-term culture
  • senescence


Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.


Keywords

  • adipose tissue
  • cellular dysfunction
  • cellular senescence
  • mesenchymal stem cells
  • obesity


miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.


Keywords

  • mesenchymal stem cells
  • miR-155-5p
  • myocardial infarction
  • rejuvenation
  • senescence


Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.


Keywords

  • aging
  • clinical translation
  • extracellular vesicles
  • mesenchymal stem cells
  • regenerative medicine
  • senescence


Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.


Keywords

  • MSC senescence
  • in vitro aging
  • in vivo aging
  • mesenchymal stem/stromal cells (MSC)
  • rejuvenating strategies


Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.


Keywords

  • RG108
  • apoptosis
  • pluripotency
  • porcine bone marrow mesenchymal stem cells
  • senescence


Extracellular Vesicles of Stem Cells to Prevent BRONJ.


Keywords

  • bisphosphonate-associated osteonecrosis of the jaw
  • cellular senescence
  • exosomes
  • mesenchymal stem cells
  • wound healing
  • zoledronic acid


Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.


Keywords

  • apoptosis
  • differentiation
  • ginsenoside Rg1
  • mesenchymal stem cells
  • preclinical study
  • proliferation
  • senescence


The Importance of Stem Cell Senescence in Regenerative Medicine.


Keywords

  • Aging
  • Mesenchymal stem cell
  • Regenerative medicine


Control of mesenchymal stem cell biology by histone modifications.


Keywords

  • Cell biology
  • Cell differentiation
  • Cellular senescence
  • Epigenetics
  • Histone modifications
  • Mesenchymal stem cells


Impact of mesenchymal stem cell senescence on inflammaging.


MeSH Terms

  • Aging
  • Cellular Senescence
  • Cytokines
  • Hematopoiesis
  • Humans
  • Immunomodulation
  • Immunosenescence
  • Inflammation
  • Macrophages
  • Mesenchymal Stem Cells


Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.


Keywords

  • COPD
  • aging
  • lung
  • newborn
  • regenerative medicine
  • stem cells


Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage.


Keywords

  • 169 MHz
  • CFU
  • senescence
  • stem cell


Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.


MeSH Terms

  • Adolescent
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Animals, Newborn
  • Cellular Senescence
  • Humans
  • Macrophage Migration-Inhibitory Factors
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Myocardial Infarction
  • Myocardium
  • Myocytes, Cardiac
  • Rats
  • Rats, Sprague-Dawley
  • Young Adult

Keywords

  • macrophage migration inhibitory factor
  • mesenchymal stem cells
  • myocardial infarction
  • rejuvenation
  • senescence


Influence of olive oil and its components on mesenchymal stem cell biology.


Keywords

  • Aging
  • Cellular differentiation
  • Cellular niche
  • Mediterranean diet
  • Mesenchymal stem cells
  • Olive oil


Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.


Keywords

  • aging
  • epigenetics
  • fate decision
  • mesenchymal stem cells
  • pathogenesis
  • regeneration


Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients.


Keywords

  • dysfunction
  • immunoregulatory
  • mesenchymal stem cells
  • senescence
  • systemic lupus erythematosus


Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.


MeSH Terms

  • Adipogenesis
  • Animals
  • Biomarkers
  • Bone Regeneration
  • Bone and Bones
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Diabetes Mellitus, Type 2
  • Glucose
  • Hyperglycemia
  • Male
  • Mesenchymal Stem Cells
  • Osteogenesis
  • Rats, Wistar

Keywords

  • Bone repair
  • Cellular senescence
  • Differentiation
  • Hyperglycaemia
  • Mesenchymal stromal cells; Endosteum
  • Type II diabetes


Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.


Keywords

  • ROS/JNK/p38 signalling
  • autophagy
  • mesenchymal stem cells
  • senescence


Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.


Keywords

  • Anoikis
  • Bioactive scaffolds
  • Bone regeneration
  • Engraftment
  • Homing
  • Hypoxia
  • Mesenchymal stem cells
  • Osteogenesis
  • Preconditioning
  • Senescence


Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.


MeSH Terms

  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Chondrocytes
  • Coculture Techniques
  • Collagenases
  • Etoposide
  • Gene Expression Regulation
  • Humans
  • Inflammation
  • Luciferases
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred Strains
  • Mice, Transgenic
  • Osteoarthritis
  • Paracrine Communication

Keywords

  • mesenchymal stem cell
  • osteoarthritis
  • senescence
  • tissue homeostasis


Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.


MeSH Terms

  • Animals
  • Cell- and Tissue-Based Therapy
  • Cellular Senescence
  • Disease Models, Animal
  • Embryonic Stem Cells
  • Extracellular Vesicles
  • Humans
  • Insulin-Like Growth Factor I
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Inbred BALB C
  • Phosphatidylinositol 3-Kinases
  • Wounds and Injuries

Keywords

  • Cellular senescence
  • Embryonic stem cells
  • Extracellular vesicles
  • IGF1/PI3K/AKT pathway
  • Mesenchymal stem cells


Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.


Keywords

  • aging
  • decoy TRAIL receptor 2 (CD264)
  • mesenchymal stem cells
  • survival


Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.


MeSH Terms

  • Acute Lung Injury
  • Age Factors
  • Animals
  • Disease Models, Animal
  • Extracellular Vesicles
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells
  • Mice
  • Treatment Outcome

Keywords

  • ARDS
  • acute lung injury
  • aging
  • extracellular vesicles
  • mesenchymal stem cells


Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.


MeSH Terms

  • Adipogenesis
  • Cell Differentiation
  • Cellular Senescence
  • Connexin 43
  • Gene Expression Regulation
  • Humans
  • Mesenchymal Stem Cells
  • Time Factors

Keywords

  • CRISPR-Cas9
  • adipogenesis
  • connexin43
  • gap junctional intercellular communication
  • mesenchymal stem cells
  • oculodentodigital dysplasia
  • senescence


Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.


Keywords

  • inflammation
  • mesenchymal stem cells
  • periodontitis
  • senescence

MTHFR[править]

One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Choline
  • Dietary Supplements
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Mice
  • Mice, Inbred C57BL
  • Recovery of Function
  • Stroke
  • Tetrahydrofolates
  • Vitamin B 12

Keywords

  • Cerebral ischemia
  • Homocysteine
  • Methylenetetrahydrofolate reductase
  • Neurodegeneration
  • Sensorimotor cortex
  • Supplementation

MTOR[править]

The roles of MTOR and miRNAs in endothelial cell senescence.


Keywords

  • Endothelium
  • MTOR
  • MicroRNAs
  • Senescence
  • Vascular aging


Autophagy drives fibroblast senescence through MTORC2 regulation.


Keywords

  • Autophagy
  • MTORC2
  • myofibroblast
  • rapamycin
  • senescence


The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.


Keywords

  • AMPK
  • GID
  • autophagy
  • longevity
  • primary cilium
  • ubiquitination

MTR[править]

Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla.


Keywords

  • Aging
  • amide proton transfer imaging
  • biomarkers
  • chemical exchange saturation transfer (CEST)
  • molecular imaging

MUC7[править]

Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Cell Line
  • Epithelial Cells
  • Female
  • Glycosylation
  • Humans
  • Male
  • Middle Aged
  • Mucins
  • N-Acetylneuraminic Acid
  • Plasmids
  • Protein Binding
  • Rheology
  • Saliva
  • Taste
  • Young Adult

Keywords

  • ageing
  • mucin
  • rheology
  • saliva
  • taste

MYB[править]

Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence.


MeSH Terms

  • Arabidopsis
  • Arabidopsis Proteins
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Plant Leaves
  • Transcriptome

Keywords 

         Phyllostachys edulis
  • NAC
  • postharvest
  • regulatory factors
  • shoot senescence

MYC[править]

Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT.


Keywords

  • Adipogenesis
  • Adipose-derived stromal cells
  • Senescence
  • hTERT
  • mTesR1

MYCN[править]

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells.


Keywords

  • Aurora kinase A
  • Cellular senescence
  • MLN8237
  • Neuroblastoma
  • Small interfering RNA

MYSM1[править]

MYSM1 Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan.


Keywords

  • DNA repair
  • Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1)
  • aging
  • senescence
  • senescence‐associated secretory phenotype (SASP)

MYT1[править]

ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis.


Keywords

  • ESC-sEVs
  • MYT1
  • aging
  • hippocampal NSCs
  • senescence

NACA[править]

Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Emergency Medical Services
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mountaineering
  • Rescue Work
  • Sex Factors
  • Young Adult

Keywords

  • MRT
  • NACA ICAR
  • SAR
  • injury
  • mechanism

NAMPT[править]

Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence.


Keywords

  • ER stress
  • NAD+
  • NAMPT
  • oxidative stress
  • premature senescence


Resistance training increases muscle NAD and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals.


Keywords

  • NAD +
  • NADH
  • aging
  • muscle
  • resistance training


Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake.


Keywords

  • NAMPT
  • T2DM
  • hNAA40
  • nicotinamide phosphoribosyltransferase
  • obesity
  • senescence
  • sirtuin-1

NDRG2[править]

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Astrocytes
  • Brain
  • DNA Damage
  • Excitatory Amino Acid Transporter 2
  • Gene Expression Regulation
  • Glial Fibrillary Acidic Protein
  • Glutamate-Ammonia Ligase
  • Humans
  • Microglia
  • Neurofibrillary Tangles
  • Tumor Suppressor Proteins
  • tau Proteins

Keywords

  • N-myc downstream regulated gene 2 (NDRG2)
  • ageing brain
  • astrocyte
  • neurofibrillary tangles

NDUFS8[править]

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.


MeSH Terms

  • Aging
  • Anesthetics, Inhalation
  • Animals
  • Animals, Genetically Modified
  • Drosophila
  • Electron Transport Complex I
  • Isoflurane
  • Male
  • Mitochondria
  • Mutation
  • Sevoflurane

NEDD8[править]

Targeting Protein Neddylation for Cancer Therapy.


MeSH Terms

  • Animals
  • Apoptosis
  • Autophagy
  • Cyclopentanes
  • Humans
  • NEDD8 Protein
  • Neoplasms
  • Pyrimidines
  • Ubiquitin-Protein Ligases
  • Ubiquitination

Keywords

  • Apoptosis
  • Autophagy
  • Cancer target
  • Inflammatory responses
  • Neddylation
  • Senescence


Effective targeting of the ubiquitin-like modifier NEDD8 for lung adenocarcinoma treatment.


Keywords

  • NEDD8
  • apoptosis
  • cullin-RING ligases
  • neddylation
  • senescence


Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence.


Keywords

  • DNA re-replication
  • MLN4924
  • NAE-inhibitor
  • canine
  • melanoma
  • senescence

NEO1[править]

Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells.


MeSH Terms

  • Aging
  • Animals
  • Female
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells
  • Homeodomain Proteins
  • Membrane Proteins
  • Mice
  • Mice, Transgenic

Keywords

  • Neogenin-1
  • aging
  • hematopoietic stem cell
  • myeloid bias
  • transplantation

NES[править]

Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models.


Keywords

  • Aging
  • Neuroendocrine system
  • Nonhuman primate

NFKB1[править]

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.


MeSH Terms

  • Adult
  • Allografts
  • Disease-Free Survival
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Middle Aged
  • NF-kappa B p50 Subunit
  • Pilot Projects
  • Polymorphism, Single Nucleotide
  • Survival Rate

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Cellular senescence
  • Graft-versus-host disease
  • NFKB1 gene
  • Senescence-associated secretory phenotype
  • Single-nucleotide polymorphism

NGF[править]

Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice.


Keywords

  • Aging
  • Anxiety-like behaviour
  • Cognitive decline
  • Hydrolysate
  • Low molecular weight peptides
  • Marine by-products
  • Memory
  • Navigation strategies
  • Neuroinflammation
  • Stress response
  • n-3 Long chain polyunsaturated fatty acids (n-3 LC-PUFAs)


Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.


Keywords

  • Aging female
  • MMP-7
  • MMP-9
  • Nerve growth factor
  • Overactive bladder
  • proNGF


Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice.


Keywords

  • aging
  • corneal epithelial cell proliferation
  • corneal sensitivity
  • corneal sensory nerves
  • mouse
  • parity
  • pregnancy


Cholinergic System and NGF Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i].


Keywords

  • NTRK1/NTRKA
  • aging
  • cholinergic system
  • fish
  • p75/NGFR


Retrograde axonal transport of BDNF and proNGF diminishes with age in basal forebrain cholinergic neurons.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Axonal Transport
  • Brain-Derived Neurotrophic Factor
  • Cholinergic Neurons
  • Humans
  • Nerve Growth Factor
  • Prosencephalon

Keywords

  • Alzheimer's disease
  • Axonal transport
  • Basal forebrain
  • Neurodegeneration
  • Neurotrophins
  • Trk receptors


C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene.


MeSH Terms

  • Aging
  • Animals
  • Blood Glucose
  • Class I Phosphatidylinositol 3-Kinases
  • Class Ia Phosphatidylinositol 3-Kinase
  • Female
  • Forkhead Transcription Factors
  • Insulin
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Growth Factor
  • Oxidative Stress
  • PC12 Cells
  • Platelet-Derived Growth Factor
  • Point Mutation
  • Proto-Oncogene Proteins c-akt
  • Rats
  • src Homology Domains

NHS[править]

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.


Keywords

  • acute coronary syndrome
  • coronary heart disease
  • immunosenescence
  • telomerase activator


Factors associated with COVID-19-related death using OpenSAFELY.


MeSH Terms

  • Adolescent
  • Adult
  • African Continental Ancestry Group
  • Age Distribution
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Asthma
  • Betacoronavirus
  • COVID-19
  • Cohort Studies
  • Coronavirus Infections
  • Diabetes Mellitus
  • Female
  • Humans
  • Hypertension
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral
  • Proportional Hazards Models
  • Risk Assessment
  • SARS-CoV-2
  • Sex Characteristics
  • Smoking
  • State Medicine
  • Young Adult


Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts.


Keywords

  • advanced practice
  • gerontology
  • older people
  • patient outcomes
  • patients
  • practice development
  • professional
  • professional issues
  • quality of life


Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling.


MeSH Terms

  • Cross-Sectional Studies
  • Gross Domestic Product
  • Health Care Rationing
  • Health Expenditures
  • Humans
  • Latent Class Analysis
  • Least-Squares Analysis
  • Life Expectancy
  • Patient Safety
  • Patient Satisfaction
  • Spain
  • State Medicine

Keywords

  • National Health Service
  • health policy
  • partial least squares structural equation modeling (PLS-SEM)
  • patient satisfaction
  • quality of healthcare


Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Comorbidity
  • Diabetes Mellitus
  • Echocardiography
  • Exercise Tolerance
  • Female
  • Heart Failure
  • Heart Ventricles
  • Humans
  • Hypertension
  • Male
  • Observational Studies as Topic
  • Prospective Studies
  • Pulse Wave Analysis
  • Research Design
  • Stroke Volume
  • Vascular Stiffness

Keywords

  • arterial stiffness
  • comorbidities
  • heart failure with preserved ejection fraction
  • pathophysiology


Challenges to concordance: theories that explain variations in patient responses.


MeSH Terms

  • Aging
  • Benchmarking
  • Communication Barriers
  • Community Health Nursing
  • Humans
  • Nurse-Patient Relations
  • State Medicine
  • United Kingdom

Keywords

  • Concordance
  • Decision making
  • Person-centred care
  • Psychological theories
  • Self-management


Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Health Behavior
  • Humans
  • Logistic Models
  • Longevity
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio

Keywords

  • aging
  • longevity
  • longitudinal study
  • optimism
  • psychological well-being

NKAP[править]

NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.


Keywords

  • NKAP
  • apoptosis
  • cyclin dependent kinase inhibitor
  • hematopoiesis
  • senescence

NKX6-1[править]

The dynamic methylome of islets in health and disease.


MeSH Terms

  • Animals
  • Cell Differentiation
  • DNA Methylation
  • Diabetes Mellitus, Type 2
  • Epigenome
  • Humans
  • Insulin-Secreting Cells

Keywords

  • Aging
  • Beta cells
  • DNA methylation
  • Endocrine pancreas
  • Epigenetics

NLRC4[править]

Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis Regulatory Proteins
  • Blotting, Western
  • Calcium-Binding Proteins
  • Cellular Senescence
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gingiva
  • Glucose
  • Hyperglycemia
  • Immunohistochemistry
  • Inflammation
  • Interferon Regulatory Factors
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RAW 264.7 Cells
  • Signal Transduction

Keywords

  • NLRC4
  • SASP
  • aging
  • cellular senescence
  • diabetes
  • gingiva
  • hyperglycemia
  • inflamm-aging
  • inflammasome
  • inflammation

NLRP12[править]

Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function.


Keywords

  • Aging
  • DNA repair
  • Hematology
  • Hematopoietic stem cells

NLRP3[править]

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.


Keywords

  • adaptive immunity
  • aging
  • innate immunity
  • longevity
  • resilience


TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.


Keywords

  • CHIP
  • IL-1β
  • TET2
  • adipose tissue
  • aging
  • clonal hematopoiesis
  • diabetes
  • insulin resistance
  • obesity
  • somatic mutations


Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome.


Keywords

  • Aging
  • Apoptosis
  • NOD-like receptor protein 3 inflammasome
  • Neuroinflammation
  • Postoperative cognitive dysfunction
  • Propofol


A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma.


Keywords

  • ASC and pannexin 1
  • MYC G4-quadruplex stabilizer
  • NLRP3
  • caspase 1
  • endoplasmic reticulum stress
  • gasdermin D
  • inflammasome
  • pyroptosis
  • senescence


Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress.


Keywords

  • Alzheimer's disease
  • amyloid β
  • astrocyte
  • interleukin-1β
  • neuroinflammation
  • senescence
  • tau


Mechanisms of NLRP3 priming in inflammaging and age related diseases.


Keywords

  • Aging
  • Inflammaging
  • Inflammasome
  • NLRP3
  • Priming
  • Senescence


Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities.


Keywords

  • NLRP3 inflammasome
  • age-related macular degeneration
  • lamivudine
  • retinal pigment epithelium
  • senescence


The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging.


Keywords

  • NLRP3 inflammasome
  • aging
  • inflammation
  • metabolism
  • mitochondria


Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated NLRP3 activation in macrophages.


Keywords

  • aging
  • and reperfusion injury
  • leucine-rich repeat containing protein 3
  • liver ischemia
  • macrophage immune response
  • nucleotide-binding domain
  • stimulator of interferon genes


Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss.


Keywords

  • aging
  • inflammasomes
  • inflammation
  • macrophages
  • osteoclasts
  • periodontitis


Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.


Keywords

  • Korean ginseng extract
  • NLRP3 inflammasome
  • aging
  • ovary
  • oxidative stress response
  • subfertility


Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression.


MeSH Terms

  • Aging
  • Animals
  • Benzylisoquinolines
  • Brain
  • Dexmedetomidine
  • Inflammasomes
  • Inflammation
  • Male
  • Mitochondria
  • Oxidative Stress
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species

Keywords

  • dementia
  • dexmedetomidine
  • inflammasomes
  • β-amyloid
  • cepharanthine


Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice.


Keywords

  • Ginsenoside Rg1
  • Kidney aging
  • NADPH oxidase 4 (NOX4)
  • NLRP3 inflammasome
  • Renal fibrosis


Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice.


Keywords

  • Aging
  • Autophagy
  • High-fat diet
  • Longevity
  • NLRP3 inflammasome
  • Obesity


Autophagy and NLRP3 inflammasome crosstalk in neuroinflammation in aged bovine brains.


Keywords

  • NLRP3 inflammasome
  • aging
  • autophagy
  • bovine
  • immunosenescence
  • neuroinflammation


NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity.


Keywords

  • Aging
  • Autophagy
  • MCC950
  • NLRP3 inflammasome
  • PPARα


NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice.


Keywords

  • NLRP3-inflammasome
  • autophagy
  • cardiac aging
  • longevity
  • morbidity
  • mortality


Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • Endothelial Progenitor Cells
  • Mice
  • NF-E2-Related Factor 2
  • NF-kappa B
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Neovascularization, Physiologic
  • Oxidative Stress

Keywords

  • NLRP3 inflammasome
  • NRF2
  • aging
  • endothelial progenitor cells
  • oxidative stress


Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Mice
  • Mice, Inbred C57BL
  • Taurine

Keywords

  • Age-related diseases
  • Glycine Transporter (GLYT)
  • NLRP3
  • Taurine Transporter (TauT)

NMI[править]

Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task.


Keywords

  • activity of daily living
  • aging
  • functional connectivity
  • motor variability
  • muscle fatigue

NMS[править]

Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences.


Keywords

  • Aging
  • Dynapenia
  • Glycated hemoglobin
  • Hyperglycemia
  • Neuromuscular strength

NMUR1[править]

[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules].


MeSH Terms

  • Aging
  • Chemistry, Pharmaceutical
  • Drug Discovery
  • Humans
  • Life Style
  • Molecular Targeted Therapy
  • Muscle Weakness
  • Muscular Atrophy
  • Myostatin
  • Neuropeptides
  • Obesity
  • Peptides
  • Receptors, Neurotransmitter
  • Structure-Activity Relationship

Keywords

  • myostatin inhibitor
  • neuromedin U receptor-selective agonist
  • peptide

NNT[править]

Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model.


Keywords

  • Outcomes
  • Physical activity
  • Successful aging
  • Systematic review


Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Databases, Factual
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Male
  • Myocardial Infarction
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Assessment
  • Secondary Prevention
  • Stroke

Keywords

  • geriatrics
  • myocardial infarction
  • secondary prevention
  • statin
  • time varying

NOP10[править]

Pseudouridylation defect due to [i]DKC1[/i] and [i]NOP10[/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis.


MeSH Terms

  • Animals
  • Cataract
  • Cell Cycle Proteins
  • Child
  • Enterocolitis
  • Female
  • Genetic Predisposition to Disease
  • Hearing Loss, Sensorineural
  • Humans
  • Longevity
  • Male
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Mutation
  • Nephrotic Syndrome
  • Nuclear Proteins
  • Pedigree
  • Protein Conformation
  • RNA, Ribosomal
  • Ribonucleoproteins, Small Nucleolar
  • Zebrafish

Keywords

  • H/ACA snoRNP
  • pediatrics
  • pseudouridylation
  • rRNA
  • telomere

NOS1[править]

Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats.


MeSH Terms

  • Aging
  • Animals
  • Chlorides
  • Endocrine Disruptors
  • Female
  • Gonadotropin-Releasing Hormone
  • Manganese Compounds
  • Neurons
  • Nitric Oxide
  • Ovary
  • Preoptic Area
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-A
  • Sexual Maturation
  • Signal Transduction
  • Uterus
  • Weaning

Keywords

  • GABA(A)R
  • GnRH
  • Manganese
  • Nitric oxide
  • Precocious puberty

NOS3[править]

Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation.


Keywords

  • endothelial cells
  • oxidative stress
  • senescence
  • tissue-engineered blood vessel
  • vascular smooth muscle cells

NOTCH1[править]

[How Does Aging Contribute to Cancer?]


MeSH Terms

  • Aged
  • Aging
  • Carcinogenesis
  • Esophageal Neoplasms
  • Humans
  • Mutation


H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice.


MeSH Terms

  • Aging
  • Animals
  • Aortic Valve
  • Aortic Valve Stenosis
  • Calcinosis
  • DNA Methylation
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA, Long Noncoding
  • Sex Factors
  • Up-Regulation

Keywords

H19

  • age
  • calcific aortic valve disease
  • epigenetics

NOTCH4[править]

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH.


Keywords

  • Aging
  • DLK
  • LC3
  • Notch signaling
  • autophagy
  • axon injury
  • axon regeneration

NOX4[править]

Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression.


Keywords

  • NOX4
  • Reactive oxygen species
  • Senescence
  • Sestrin2

NPM1[править]

Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Cell Separation
  • Culture Media
  • Flow Cytometry
  • Longevity
  • Macrophage Colony-Stimulating Factor
  • Macrophages
  • Mole Rats
  • Recombinant Proteins

NPR1[править]

The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana.


Keywords

  • Leaf senescence
  • NPR1
  • Probenazole
  • Salicylic acid
  • WRKY46
  • WRKY6


Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis.


Keywords

  • Early senescence
  • H(+)/Ca(2+)exchanger 1
  • Plant defense
  • Salicylic acid
  • Scopoletin

NPW[править]

Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study.


MeSH Terms

  • Aged
  • Aging
  • Cognition
  • Cognitive Aging
  • Cognitive Dysfunction
  • Employment
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Retirement
  • Time

NPY[править]

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.


Keywords

  • Autophagy
  • Caloric restriction mimetic
  • Cellular senescence
  • Human aging


Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice.


MeSH Terms

  • Animals
  • Caloric Restriction
  • Dietary Supplements
  • Drugs, Chinese Herbal
  • Female
  • Ghrelin
  • Longevity
  • Male
  • Mice
  • Mice, Knockout
  • Oxidative Stress

Keywords

  • calorie restriction
  • ghrelin
  • longevity
  • metabolism
  • oxidative stress

NRAS[править]

Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.


Keywords

  • biliary epithelial cell
  • cellular senescence
  • extracellular vesicles
  • primary sclerosing cholangitis
  • senescence-associated secretory phenotype


STAT3 Relays a Differential Response to Melanoma-Associated [i]NRAS[/i] Mutations.


Keywords

  • NRAS
  • STAT3
  • melanoma
  • mutation
  • oncogene-induced senescence


Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.


MeSH Terms

  • Animals
  • Apoptosis
  • Carcinogenesis
  • Cell Differentiation
  • DNA (Cytosine-5-)-Methyltransferases
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Gene Knock-In Techniques
  • Leukemia, Myeloid, Acute
  • Longevity
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Monomeric GTP-Binding Proteins
  • Mutation
  • Phenotype
  • Pilot Projects
  • Proto-Oncogene Proteins c-myc
  • RNA-Seq
  • Transcription, Genetic

Keywords

  • Acute myeloid leukemia
  • DNMT3A mutation
  • Myc activation
  • Nras G12D

NRL[править]

Development of a cyclophosphamide stress test to predict resilience to aging in mice.


Keywords

  • Aging mice
  • Cyclophosphamide
  • Neutrophil lymphocyte ratio
  • Resilience to aging
  • Stress test
  • WBC count

NRM[править]

Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Autografts
  • Female
  • Hematopoiesis
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Lymphoma, Non-Hodgkin
  • Male
  • Middle Aged
  • Multiple Myeloma
  • Retrospective Studies

Keywords

  • Autologous
  • Clonal hematopoiesis
  • Lymphoma
  • Multiple myeloma
  • Nonrelapse mortality
  • Survivors
  • Transplantation

NSF[править]

Effects of air pollution on children from a socioecological perspective.


MeSH Terms

  • Air Pollution
  • Child Mortality
  • Child, Preschool
  • Environment
  • Humans
  • Income
  • Infant
  • Life Expectancy
  • Retrospective Studies
  • Socioeconomic Factors
  • Sociological Factors

Keywords

  • Deaths of children under age 5
  • Electrification rates
  • Income
  • Inequality in life expectancy
  • Natural resource depletion
  • Non-solid fuel
  • Outdoor and indoor air pollution
  • Socioecological perspective

NT5E[править]

The NT5E gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef.


MeSH Terms

  • 5'-Nucleotidase
  • Animals
  • Cattle
  • Diaphragm
  • Food Handling
  • Inosine Monophosphate
  • Muscle, Skeletal
  • Polymorphism, Single Nucleotide
  • Postmortem Changes
  • Red Meat
  • Taste

Keywords

  • Inosine 5′-monophosphate
  • Japanese Black beef
  • Meat quality
  • NT5E
  • Postmortem aging

NTHL1[править]

Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals.


Keywords

  • AP endonuclease
  • Aging
  • DNA glycosylases
  • DNA repair
  • Mitochondria

NUCB2[править]

Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish.


Keywords

  • Nesf-1
  • Nothobranchius furzeri
  • aging
  • brain-gut axis
  • vertebrate

OGA[править]

NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • Female
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Motor Neurons
  • Muscle Denervation
  • Oxidative Stress
  • Paralysis
  • beta-N-Acetylhexosaminidases

Keywords

  • ALS
  • NPGPx
  • O-GlcNAcylation
  • OGA
  • aging
  • motor neuron
  • oxidative stress

OGG1[править]

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • DNA, Mitochondrial
  • Female
  • Homeostasis
  • Humans
  • Inflammation
  • Iron
  • Male
  • Mitochondria, Muscle
  • Quadriceps Muscle
  • Young Adult

Keywords

  • ZIP
  • ferritin
  • hepcidin
  • inflammation
  • iron overload
  • mitochondrial dysfunction
  • mtDNA
  • muscle aging
  • physical performance
  • transferrin

OGT[править]

ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan.


Keywords

  • Caenorhabditis elegans
  • GATA factor ELT-2
  • OGT-1
  • lifespan


Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain.


MeSH Terms

  • Acetylglucosamine
  • Acylation
  • Aging
  • Animals
  • Cognition
  • Male
  • Mice
  • Mice, Knockout
  • N-Acetylglucosaminyltransferases

Keywords

  • O-GlcNAcylation
  • OGT
  • aging
  • brain
  • cognition
  • hippocampus
  • rejuvenation
  • synaptic plasticity

OSM[править]

Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life.


Keywords

  • LGBT
  • Sexual minorities
  • cohort differences
  • discrimination
  • friendship aging
  • internalized homonegativity
  • minority stress
  • outness
  • social support

OTC[править]

Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates.


MeSH Terms

  • Aging
  • Animals
  • Bass
  • Ecosystem
  • Environmental Monitoring
  • Population Dynamics
  • Reproduction
  • Rivers

P2RY12[править]

Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.


Keywords

  • Aging
  • Brain infiltrating myeloid cells
  • CD45
  • Cerebral amyloid angiopathy
  • Microglia
  • Neuroinflammation
  • P2RY12
  • Stroke
  • Tmem119


Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model.


Keywords

  • Aging
  • CD68
  • Glaucoma
  • Iba-1
  • Inflammation
  • MHCII
  • Microglia
  • Mouse
  • Ocular hypertension
  • P2RY12
  • Retina


Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Humans
  • Immunohistochemistry
  • Inflammation
  • Macrophages
  • Microglia
  • Phenotype
  • Plaque, Amyloid
  • Receptors, Purinergic P2Y2

Keywords

  • Alzheimer’s disease
  • activation phenotypes
  • amyloid
  • immunohistochemistry
  • microglia
  • neuroinflammation
  • temporal cortex

P4HA2[править]

Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Asian Continental Ancestry Group
  • Axial Length, Eye
  • Child
  • Child, Preschool
  • China
  • Cross-Sectional Studies
  • DNA Mutational Analysis
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myopia, Degenerative
  • Phenotype
  • Retinal Diseases
  • Vision, Low
  • Young Adult

P4HA3[править]

Age-associated genes in human mammary gland drive human breast cancer progression.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Animals
  • Biomarkers, Tumor
  • Breast
  • Breast Neoplasms
  • Disease Progression
  • Dyneins
  • Female
  • Gene Expression Regulation, Neoplastic
  • Heterografts
  • Humans
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Middle Aged
  • Procollagen-Proline Dioxygenase
  • Prognosis
  • Survival Rate
  • Tumor Cells, Cultured

Keywords

  • ALX4
  • Aging
  • Breast cancer
  • DYNLT3
  • Gene expression
  • P4HA3
  • Relapse-free survival
  • Transcriptomics
  • Tumor progression

PAH[править]

Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber.


MeSH Terms

  • Aerosols
  • Biomass
  • Carbon
  • Ozone
  • Smog
  • Soot

Keywords

  • Absorption Ångström exponent
  • Brown carbon
  • Light absorption
  • Ozone aging
  • Soot particles


Factors associated with pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc).


MeSH Terms

  • Aging
  • Humans
  • Natriuretic Peptide, Brain
  • Pulmonary Arterial Hypertension
  • Risk Factors
  • Scleroderma, Systemic


Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia.


Keywords

  • Aging
  • Dementia
  • Long-Term Care

PAM[править]

Relationship between patient activation measurement and self-rated health in patients with chronic diseases.


Keywords

  • Aging population
  • Chronic diseases
  • Patient activation measurement
  • Primary health care
  • Self-rated health


Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation.


Keywords

  • GABA
  • aging
  • cognition
  • neurotrophic effect
  • positive allosteric modulator


The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan.


MeSH Terms

  • Aging
  • Aging, Premature
  • Animals
  • Behavior, Animal
  • Female
  • Housing, Animal
  • Longevity
  • Lymphocytes
  • Macrophages
  • Mice
  • Oxidative Stress
  • Social Environment

Keywords

  • Behavior
  • Immunity
  • Mean lifespan
  • Prematurely aging mice
  • Social environmental strategy

PAX8[править]

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.


MeSH Terms

  • Aging
  • Animals
  • Fatty Liver
  • Insulin Resistance
  • Liver
  • Liver Neoplasms
  • Male
  • Mice
  • Mice, Knockout
  • PAX8 Transcription Factor
  • Thyroid Hormones

Keywords

  • glucose metabolism
  • healthspan
  • hyperthyroidism
  • hypothyroidism
  • lifespan
  • thyroid hormones

PBX1[править]

Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.


Keywords

  • AKT
  • Hair follicle mesenchymal stem cells
  • PBX1
  • Protein purification
  • Senescence
  • TAT

PC[править]

Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial.


Keywords

  • Aging
  • Behaviour change
  • Physical functioning
  • Protein
  • Sarcopenia
  • e-Health


Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography.


Keywords

  • Aging
  • Diastolic function
  • Phase-contrast MRI
  • Right ventricle


Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study.


Keywords

  • Deep brain stimulation
  • Dystonia
  • Globus pallidus internus
  • Pulse generator longevity
  • Pulse width


Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer.


Keywords

  • Adverse events
  • Chemotherapy
  • Gemcitabine
  • Geriatrics
  • Nab-paclitaxel
  • Pancreatic cancer


Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes.


Keywords

  • 17-β-Oestradiol
  • aging
  • oxidative stress
  • phytoestrogen
  • surfactant
  • type ii pneumocytes


Pacing During 200-m Competitive Masters Swimming.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Athletes
  • Athletic Performance
  • Competitive Behavior
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Swimming


Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry.


Keywords

  • aging
  • behavioral risk factors
  • geriatric oncology
  • healthy aging
  • prostate cancer survivorship


Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Brain
  • Cerebral Ventricles
  • Cerebrospinal Fluid
  • Cerebrovascular Circulation
  • Cross-Sectional Studies
  • Female
  • Hemodynamics
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged

Keywords

  • Aging
  • Arterial cerebral blood flow
  • CSF flow
  • PC-MRI
  • Pulsatility
  • Venous cerebral blood flow


Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aging
  • Cancer Survivors
  • Case-Control Studies
  • Disease-Free Survival
  • Germany
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms
  • Quality of Life
  • Surveys and Questionnaires
  • Young Adult

Keywords

  • Health-related quality of life
  • Long-term survivor
  • Population-based
  • Prostate cancer


Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence.


MeSH Terms

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Cell Line, Tumor
  • Cellular Senescence
  • Docetaxel
  • Forkhead Box Protein O1
  • Humans
  • Male
  • Mice
  • Mice, Nude
  • Nanostructures
  • Polyphenols
  • Prostatic Neoplasms
  • Receptor, Transforming Growth Factor-beta Type I
  • Signal Transduction
  • Tannins
  • Transplantation, Heterologous

Keywords

  • DSAs
  • apoptosis
  • docetaxel
  • nanoassemblies
  • prostate cancer
  • senescence


An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study.


Keywords

  • cognition
  • dementia
  • healthy aging
  • memory
  • virtual reality

PCNA[править]

Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice.


Keywords

  • BER
  • Pol β
  • menopause
  • oocytes
  • ovarian aging


[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.]


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • HSP90 Heat-Shock Proteins
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Pregnancy
  • Young Adult

Keywords

  • HSP90
  • PCNA
  • aging
  • fibroblasts
  • skin


A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity.


Keywords

  • Argentatin A
  • PCNA
  • antiproliferative
  • antitumor
  • apoptosis
  • cell senescence
  • colon cancer
  • xenografts


[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • Humans
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Pregnancy
  • Protein-Serine-Threonine Kinases
  • Skin Aging
  • Trans-Activators
  • Young Adult

Keywords

  • CD31
  • PCNA
  • TAZ
  • aging
  • blood vessels
  • fibroblasts
  • skin


[Mechanosensitive Yes-associated protein in human skin during aging.]


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Dermis
  • Endothelial Cells
  • Female
  • Fibroblasts
  • Humans
  • Middle Aged
  • Pregnancy
  • Skin Aging
  • Transcription Factors

Keywords

  • CD31
  • PCNA
  • YAP
  • aging
  • blood vessels
  • fibroblasts
  • skin


[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.]


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Vessels
  • Child
  • Child, Preschool
  • Dermis
  • Female
  • Fibroblasts
  • Humans
  • Infant
  • Ion Channels
  • Male
  • Middle Aged
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Pregnancy
  • Proliferating Cell Nuclear Antigen
  • Skin Aging

Keywords

  • CD31
  • PCNA
  • Piezo1
  • aging
  • blood vessels
  • fibroblasts
  • skin

PCSK9[править]

Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoproteins B
  • Atherosclerosis
  • Cardiovascular Diseases
  • Cardiovascular System
  • Cholesterol
  • Humans
  • Lipid Metabolism
  • Lipoproteins
  • Lipoproteins, LDL
  • Risk Factors


The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process - is there a link?


Keywords

  • PCSK9
  • atherosclerosis
  • cholesterol
  • inflammation
  • vascular aging

PDCD4[править]

Petal abscission in roses is associated with the activation of a truncated version of the animal PDCD4 homologue, RbPCD1.


MeSH Terms

  • Amino Acid Sequence
  • Arabidopsis
  • Gene Expression Regulation, Plant
  • Plant Proteins
  • Plants, Genetically Modified
  • Programmed Cell Death 1 Receptor
  • Rosa
  • Sequence Alignment
  • Transcription Factors

Keywords

  • Ethylene
  • Heat shock
  • Inflorescence
  • MA3 domain
  • PDCD4
  • Repression
  • Senescence

PDE2A[править]

TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Cognition
  • Cognition Disorders
  • Cognitive Dysfunction
  • Cyclic AMP
  • Cyclic GMP
  • Cyclic Nucleotide Phosphodiesterases, Type 2
  • Male
  • Memory Disorders
  • Memory, Episodic
  • Phosphodiesterase Inhibitors
  • Pyrazines
  • Pyridines
  • Rats
  • Rats, Inbred F344
  • Rats, Long-Evans
  • Rats, Sprague-Dawley

Keywords

  • Aging
  • Cognition
  • PDE2A
  • TAK-915

PDE4D[править]

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau.


Keywords

  • Alzheimer’s disease
  • PDE4D
  • aging
  • tau
  • working memory

PDE5A[править]

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.


MeSH Terms

  • Aging
  • Animals
  • Bone Density
  • Bone and Bones
  • Brain
  • Cell Differentiation
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Drug Repositioning
  • Erectile Dysfunction
  • Humans
  • Male
  • Mice
  • Middle Aged
  • Models, Animal
  • Models, Molecular
  • Neurons
  • Osteoblasts
  • Osteoclasts
  • Osteogenesis
  • Osteoporosis
  • Osteoporotic Fractures
  • Phosphodiesterase 5 Inhibitors
  • Primary Cell Culture
  • Tadalafil
  • Vardenafil Dihydrochloride

Keywords

  • PDE5 inhibitor
  • computational modeling
  • cyclic GMP
  • osteoporosis
  • resorption

PDK1[править]

Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.


Keywords

  • PDK1
  • cellular senescence
  • network modeling
  • skin aging
  • systems biology


The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged PDK1 K465E Knock-In Mice.


Keywords

  • PI3K/Akt
  • RDoC
  • aging
  • animal model
  • anxiety
  • cognition
  • fine tuning
  • signaling pathway

PER1[править]

Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells.


MeSH Terms

  • ARNTL Transcription Factors
  • Age Factors
  • Aging
  • CLOCK Proteins
  • Caffeic Acids
  • Cell Line
  • Circadian Clocks
  • Circadian Rhythm
  • Fibroblasts
  • Humans
  • NF-E2-Related Factor 2
  • Polyphenols
  • Quercetin
  • Receptors, Glucocorticoid
  • Resveratrol
  • Sirtuin 1

Keywords

  • Caffeic acid
  • Circadian clock genes
  • NR1D1
  • NRF2
  • Quercetin
  • Resveratrol

PER2[править]

NAD Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging.


MeSH Terms

  • ARNTL Transcription Factors
  • Age Factors
  • Aging
  • Animals
  • CLOCK Proteins
  • Circadian Clocks
  • Circadian Rhythm
  • Cytokines
  • Female
  • HEK293 Cells
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NAD
  • Period Circadian Proteins
  • Sirtuin 1
  • Sirtuins

Keywords

  • NAD(+)
  • SIRT1
  • aging
  • circadian
  • clock
  • heat shock factor 1
  • liver
  • nicotinamide mononucleotide
  • nicotinamide riboside
  • transcriptomics

PEX19[править]

A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells.


MeSH Terms

  • Amino Acid Transport Systems, Basic
  • Cellular Senescence
  • DNA Replication
  • Flap Endonucleases
  • Gene Ontology
  • Genetic Techniques
  • Genomic Instability
  • Membrane Proteins
  • Mutagenesis
  • Mutation
  • Mutation Accumulation
  • Mutation Rate
  • Nuclear Pore Complex Proteins
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Single-Strand Specific DNA and RNA Endonucleases

Keywords

  • genome stability
  • high-throughput screen
  • mutagenesis
  • mutation rate
  • replicative aging
  • yeast

PEX5[править]

Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.


Keywords

  • Aging brain
  • PEX5
  • Peroxisomal protein

PFAS[править]

Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden.


Keywords

  • EPIC chip
  • Environmental pollutant
  • Epigenetic aging
  • Epigenetics
  • PFAS
  • Perfluoroalkyl substance


Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.


MeSH Terms

  • Alkanesulfonic Acids
  • Animals
  • Caprylates
  • Daphnia
  • Fatty Acids
  • Fluorocarbons
  • Humans
  • Lipid Metabolism
  • Longevity
  • Reproduction

Keywords

  • Fatty acid
  • Fecundity
  • Gene expression
  • PFAS toxicity
  • Perfluorooctane sulfonate (PFOS)
  • Perfluorooctanoic acid (PFOA)


The effect of weathering on per- and polyfluoroalkyl substances (PFASs) from durable water repellent (DWR) clothing.


MeSH Terms

  • Acrylates
  • Alcohols
  • Clothing
  • Environmental Monitoring
  • Fluorocarbon Polymers
  • Fluorocarbons
  • Humidity
  • Models, Chemical
  • Textiles
  • Water
  • Water Pollutants, Chemical
  • Weather

Keywords

  • Aging
  • Durable water repellency
  • Outdoor clothing
  • Per- and polyfluoroalkyl substances
  • Textile
  • Weathering

PGC[править]

The Aging Stress Response and Its Implication for AMD Pathogenesis.


Keywords

  • AMD
  • DNA damage response
  • PGC-1α
  • SIRT1
  • age-related macular degeneration
  • aging
  • autophagy
  • insulin/IGF-1
  • mitochondrial quality control
  • the aging stress response


Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis.


Keywords

  • Aging
  • Hippocampal neurogenesis
  • Immunohistochemistry
  • PGC-1α
  • Transgenic mice
  • Voluntary running


Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link.


Keywords

  • AMPK signaling pathway
  • PGC-1α signaling pathway
  • aging
  • autophagy
  • gut axis
  • inflammation
  • insulin resistance
  • sarcopenic obesity


Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats.


Keywords

  • aging
  • caloric restriction
  • ischemia/reperfusion
  • kidney injury
  • mitochondria


Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults.


Keywords

  • aging
  • mitochondrial dynamics
  • mitochondrial function


PGC-1α-mediated regulation of mitochondrial function and physiological implications.


Keywords

  • aging
  • exercise metabolism
  • insulin resistance
  • mitochondrial metabolism
  • muscle metabolism
  • muscle physiology
  • métabolisme mitochondrial
  • métabolisme musculaire
  • métabolisme à l’effort
  • physiologie musculaire
  • résistance à l’insuline
  • vieillissement


Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.


Keywords

  • Down syndrome
  • PGC-1α/PPARGC1A
  • aging
  • mTOR
  • mitochondrial dynamics
  • mitochondrial function
  • mitochondrial network


Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner.


Keywords

  • ADP sensitivity
  • ROS
  • aging
  • autophagy


A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway.


Keywords

  • alcalase
  • bioactive peptides
  • cardio-protection
  • hepato-protection
  • longevity


Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells.


Keywords

  • mitochondria
  • nucleoid remodeling
  • p16INK4a silence
  • p53-p21-PKCζ activation
  • senescence


[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction].


MeSH Terms

  • Adipose Tissue, White
  • Aging
  • Animals
  • Caloric Restriction
  • Gene Expression
  • Humans
  • Longevity
  • Mice
  • Organelle Biogenesis
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Sirtuin 3
  • Sterol Regulatory Element Binding Protein 1
  • Up-Regulation

Keywords

  • caloric restriction (CR)
  • fatty acid biosynthesis
  • mitochondria
  • white adipose tissue (WAT)


Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle.


Keywords

  • Aging
  • Kynurenine aminotransferases
  • Mitochondria
  • Muscle fiber-type
  • Skeletal muscle


Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs.


Keywords

  • mitochondria
  • oxidative stress
  • pig
  • postovulatory aging
  • ubiquinol-10


Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biopsy
  • Case-Control Studies
  • Energy Metabolism
  • Humans
  • Jamaica
  • Male
  • Middle Aged
  • Mitochondria
  • Muscle, Skeletal
  • NAD
  • Oxidation-Reduction
  • Oxidative Phosphorylation
  • Oxidative Stress
  • Proteostasis
  • Sarcopenia
  • Singapore
  • United Kingdom


MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities.


Keywords

  • diabetic retinopathy
  • miR-34a
  • mitochondrial dysfunction
  • vascular senescence


Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis.


MeSH Terms

  • Aging
  • Animals
  • Blood Proteins
  • Cytokines
  • Female
  • Hippocampus
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Muscle, Skeletal
  • Neurogenesis
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Reproducibility of Results

PGK2[править]

Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice.


MeSH Terms

  • Aging
  • Animals
  • Arsenic
  • Cell Cycle Proteins
  • DEAD-box RNA Helicases
  • Gene Expression Profiling
  • Male
  • Mice
  • RNA, Messenger
  • Spermatids
  • Spermatogenesis
  • Spermatozoa

Keywords

  • Arsenic
  • Elongation of spermatids
  • Male reproduction
  • Spermatogenesis

PGLS[править]

547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Carboxylic Ester Hydrolases
  • Macaca mulatta
  • Male
  • Mice
  • Transcriptome

Keywords

  • Brain aging
  • Multiple brain regions
  • PGLS
  • Rhesus macaques
  • Transcriptome

PIEZO1[править]

Niche stiffness underlies the ageing of central nervous system progenitor cells.


MeSH Terms

  • Adult Stem Cells
  • Aging
  • Animals
  • Animals, Newborn
  • Cell Count
  • Central Nervous System
  • Extracellular Matrix
  • Female
  • Humans
  • Membrane Proteins
  • Multipotent Stem Cells
  • Oligodendroglia
  • Rats
  • Stem Cell Niche

PINK1[править]

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].


Keywords

  • aging
  • caenorhabditis elegans
  • mitophagy
  • neurodegenerative diseases
  • spermidine


Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.


Keywords

  • Aging
  • Dopamine
  • Electrophysiology
  • Firing
  • Mouse
  • Substantia nigra


Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.


Keywords

Drosophila

  • MAPK-ERK-ETS signaling
  • Parkinson's disease
  • SMARCA4/Brahma
  • aging
  • neurodegeneration


SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via PINK1-dependent mitophagy.


Keywords

  • SIRT1
  • compression
  • mitophagy
  • nucleus pulposus
  • senescence


Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.


Keywords

  • Drosophila melanogaster
  • Levodopa induced dyskinesia
  • PINK1B9
  • Parkinsonism
  • Parkinson’s disease
  • aging
  • antioxidant activity
  • catalase
  • climbing index
  • lifespan
  • oxidative stress
  • propolis


Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the PINK1/PARKIN pathway.


Keywords

  • PARKIN pathway
  • PINK1
  • compression
  • intervertebral disc
  • mitophagy
  • senescence


Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.


MeSH Terms

  • Autophagy
  • Breast Neoplasms
  • Cell Culture Techniques
  • Cell Line, Tumor
  • Doxorubicin
  • Drugs, Chinese Herbal
  • Female
  • Ginsenosides
  • Humans
  • Mitochondria
  • Oxidative Stress

Keywords

  • ROS
  • cancer growth
  • cellular senescence
  • chemotherapy
  • ginsenoside Rh2
  • mitophagy


Mitochondrial DNA heteroplasmy rises in substantial nigra of aged PINK1 KO mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • DNA Copy Number Variations
  • DNA, Mitochondrial
  • Gene Frequency
  • Mice, Knockout
  • Mutation Rate
  • Protein Kinases
  • Substantia Nigra

Keywords

  • PINK1
  • Parkin
  • Parkinson’s disease
  • mtDNA heteroplasmy

PIP[править]

Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study.


MeSH Terms

  • Aged
  • Cross-Sectional Studies
  • Female
  • Geriatrics
  • Humans
  • Inappropriate Prescribing
  • Independent Living
  • Male
  • Multimorbidity
  • Polypharmacy
  • Potentially Inappropriate Medication List
  • Prevalence
  • Primary Health Care
  • Risk
  • Spain


Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ).


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Drug Prescriptions
  • Female
  • Follow-Up Studies
  • Forecasting
  • Hospitalization
  • Humans
  • Inappropriate Prescribing
  • Longitudinal Studies
  • Male
  • New Zealand
  • Patient Discharge
  • Potentially Inappropriate Medication List

Keywords

  • Appropriate prescribing
  • Ethnicity
  • Longitudinal study
  • Older people

PLIN2[править]

Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.


MeSH Terms

  • Animals
  • Atrial Fibrillation
  • Connexin 43
  • Gene Knock-In Techniques
  • Heart Atria
  • Isolated Heart Preparation
  • Lipid Droplets
  • Mice
  • Mice, Transgenic
  • Microscopy, Electron
  • Myocytes, Cardiac
  • Perilipin-2
  • Sterol Esterase
  • Triglycerides
  • Voltage-Sensitive Dye Imaging

Keywords

  • aging
  • cardiac steatosis
  • gap junction
  • lipid droplets
  • lipotoxic arrhythmia

PLK4[править]

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.


Keywords

  • Yes-associated protein
  • cellular senescence
  • hepatocellular carcinoma
  • polo-like kinase 4 associated lncRNA
  • talazoparib


Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells.


Keywords

  • AURKA
  • Osteosarcoma
  • PLK4
  • quiescence
  • senescence

PLN[править]

An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends.


Keywords

  • Polish health care system
  • ageing society
  • gerontology
  • healthcare
  • hospital costs
  • length and cost of hospitalization

PML[править]

Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients.


Keywords

  • Multiple sclerosis
  • PML
  • fumarate
  • immunosenescence
  • lymphopenia


PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.


Keywords

  • HGPS
  • PML2
  • senescence
  • thread-like PML NBs

PNN[править]

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.


Keywords

  • Brain aging
  • Chondroitin sulfate proteoglycan
  • Extracellular matrix
  • Hyaluronan
  • Perineuronal net

PNP[править]

Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction.


Keywords

  • TDMT
  • aging
  • kinesthesia
  • pointing task
  • position estimation
  • somatosensory temporal discrimination
  • temporal discrimination threshold

POLL[править]

Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Australia
  • Cancer Survivors
  • Cohort Studies
  • Female
  • Humans
  • Life Expectancy
  • Male
  • Middle Aged
  • Neoplasms

Keywords

  • Australia
  • Cancer
  • Life expectancy
  • Survival
  • Temporal

POLR3A[править]

Nucleolar disruption, activation of P53 and premature senescence in POLR3A-mutated Wiedemann-Rautenstrauch syndrome fibroblasts.


Keywords

  • Cell senescence
  • DNA damage
  • Nucleolus
  • Nucleus
  • RNA polymerase III subunit A (POLR3A)
  • Wiedemann-Rautenstrauch syndrome

POMC[править]

Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding.


MeSH Terms

  • Aging
  • Animals
  • Body Weight
  • Brain
  • Diet, High-Fat
  • Energy Metabolism
  • Female
  • Homeostasis
  • Insulin Resistance
  • Liver
  • Male
  • Mice
  • Mice, Knockout
  • Motor Activity
  • Nerve Tissue Proteins
  • Neurons
  • Pro-Opiomelanocortin
  • Receptors, G-Protein-Coupled
  • Sex Factors

POR[править]

The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans.


Keywords

  • Evans’ index
  • aging
  • brain
  • enlargement
  • hydrocephalus
  • normal pressure
  • ventricular system

POT1[править]

MiR-185 targets POT1 to induce telomere dysfunction and cellular senescence.


Keywords

  • aging
  • cellular senescence
  • miR-185
  • protection of telomere 1
  • telomere dysfunction


Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.


Keywords

  • Cancer genomics
  • Senescence

POU5F1[править]

Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells.


Keywords

  • ALDH family
  • Adipose stem cells
  • Aging
  • Shelterin complex
  • Spheroid
  • Telomere length

PPID[править]

Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population.


MeSH Terms

  • Aging
  • Animals
  • Body Composition
  • Cytokines
  • Female
  • Folic Acid
  • Horse Diseases
  • Horses
  • Inflammation
  • Male
  • Nutrients
  • Pituitary Diseases
  • Pituitary Gland, Intermediate

Keywords

  • Horse
  • Inflamm-aging
  • Muscle
  • Nutrition
  • Pituitary pars intermedia dysfunction
  • Senior

PRDM8[править]

PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation.


Keywords

  • Aging
  • Aplastic anemia
  • DNA methylation
  • Dyskeratosis congenita
  • Epigenetic clock
  • Hematopoietic differentiation
  • Neuronal differentiation
  • PRDM8
  • Telomere
  • iPSC

PRDX1[править]

Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway.


MeSH Terms

  • Animals
  • Apoptosis
  • Cellular Senescence
  • Diet, High-Fat
  • Dietary Supplements
  • Fas Ligand Protein
  • Hepatocytes
  • Metabolic Networks and Pathways
  • Mice, Knockout
  • Non-alcoholic Fatty Liver Disease
  • Oxidative Stress
  • Proteins
  • Steroid Hydroxylases
  • Tumor Suppressor Protein p53
  • Vitamin D
  • fas Receptor

Keywords

  • Active vitamin D
  • Apoptosis
  • Nonalcoholic fatty liver disease
  • Oxidative stress
  • Senescence
  • p53 pathway

PRDX3[править]

Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin.


Keywords

  • Ginsenoside Rg3(S)
  • Human dermal fibroblast
  • Label-free quantitative proteomics
  • Restoration
  • Senescence

PRDX6[править]

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task.


Keywords

  • PRDX6
  • aging
  • dentate gyrus
  • hippocampus
  • hole-board
  • peroxiredoxin
  • proteomics
  • spatial memory

PRKDC[править]

DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.


MeSH Terms

  • Animals
  • Cell Line
  • Cell Proliferation
  • Cellular Senescence
  • Chromones
  • DNA Damage
  • DNA Repair
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins
  • Female
  • Fibroblasts
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • Lung
  • Mesenchymal Stem Cells
  • Mice
  • Mice, SCID
  • Morpholines

Keywords

  • DNA-PKcs
  • IPF
  • Mesenchymal progenitor cells
  • Senescence

PRL[править]

Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.


MeSH Terms

  • Animals
  • Carcinogenesis
  • Female
  • HEK293 Cells
  • Humans
  • Immediate-Early Proteins
  • Longevity
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nedd4 Ubiquitin Protein Ligases
  • PTEN Phosphohydrolase
  • Protein Tyrosine Phosphatases
  • Proto-Oncogene Proteins c-akt
  • Ubiquitination

Keywords

  • NEDD4
  • PRL2
  • PTEN
  • protein tyrosine phosphatases
  • ubiquitination


Prolactin mitigates deficiencies of retinal function associated with aging.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Electroretinography
  • Mice, Inbred C57BL
  • Nerve Growth Factors
  • Neuroglia
  • Prolactin
  • Retina
  • Retinal Degeneration

Keywords

  • Aging
  • Apoptosis
  • Glia activation
  • Hormone
  • Mesotopic and photopic electroretinogram
  • Retina


A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Datasets as Topic
  • Estrogen Receptor alpha
  • Female
  • Gene Expression Profiling
  • Humans
  • Mammary Neoplasms, Experimental
  • Mice
  • Prolactin
  • Proto-Oncogene Proteins p21(ras)
  • Rats
  • Signal Transduction
  • Transgenes

Keywords

  • ER+ breast cancer
  • Ras mutations
  • breast cancer
  • genomic analyses
  • mouse models
  • prolactin

PRNP[править]

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.


MeSH Terms

  • Adult
  • Aging
  • Amyloid
  • Animals
  • Brain
  • Codon
  • Heterozygote
  • Homozygote
  • Humans
  • Mice, Transgenic
  • Middle Aged
  • Prions

PROC[править]

Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation.


Keywords

  • actigraphy
  • aging
  • sleep duration
  • sleep in women
  • sleep quality

PSD[править]

Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice.


Keywords

  • aging
  • brain
  • cortex
  • glutamate receptor
  • synapse
  • vesicle


Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats.


Keywords

  • DKK-1
  • Wnt
  • brain aging
  • exercise
  • β-catenin


Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity.


Keywords

  • Aging
  • Mitochondrial function
  • Neuroscience
  • Oxidative stress

PSEN2[править]

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2.


MeSH Terms

  • Aging
  • Alternative Splicing
  • Alzheimer Disease
  • Animals
  • Animals, Genetically Modified
  • Brain
  • Datasets as Topic
  • Disease Models, Animal
  • Down-Regulation
  • Female
  • Frameshift Mutation
  • Gene Editing
  • Gene Regulatory Networks
  • Heterozygote
  • Humans
  • Microglia
  • Presenilin-1
  • Presenilin-2
  • Protein Isoforms
  • Proteomics
  • RNA-Seq
  • Up-Regulation
  • Zebrafish
  • Zebrafish Proteins


Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition.


Keywords

  • Aging
  • Alzheimer's
  • Carbamazepine
  • Corneal kindling
  • Diazepam
  • Epilepsy
  • Lamotrigine
  • Levetiracetam
  • Presenilin
  • Seizures
  • Valproic acid

PSMD11[править]

The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.


Keywords

  • Age-related hearing loss
  • Aging
  • D-galactose
  • PSMD11
  • Proteasome

PSMD14[править]

Upregulation of deubiquitinase PSMD14 in lung adenocarcinoma (LUAD) and its prognostic significance.


Keywords

  • PMSD14
  • apoptosis
  • deubiquitinating enzyme
  • lung adenocarcinoma
  • prognosis
  • senescence

PTEN[править]

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.


Keywords

  • FGF1
  • GDF-15
  • MMPs
  • PTEN
  • TIMP1
  • docetaxel
  • prostate cancer metastasis
  • senescence
  • senescence-associated secretory phenotype (SASP)
  • senolytic therapy


Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients.


Keywords

  • Alzheimer's disease
  • DRP1
  • FIS1
  • aging
  • mitochondrial dynamics
  • mitophagy


Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells.


Keywords

  • Extracellular vesicle
  • bone loss
  • bone marrow MSCs
  • cellular senescence
  • embryonic stem cells


The precursor of PI(3,4,5)P alleviates aging by activating daf-18(Pten) and independent of daf-16.


MeSH Terms

  • Aging
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cell Line, Tumor
  • Female
  • Forkhead Transcription Factors
  • Inositol
  • Locomotion
  • Longevity
  • Metabolic Networks and Pathways
  • Metabolomics
  • Mice
  • Mitophagy
  • Models, Animal
  • PTEN Phosphohydrolase
  • Phosphatidylinositol Phosphates
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
  • RNA Interference
  • RNA-Seq


Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis.


MeSH Terms

  • Animals
  • Antioxidants
  • Cell Line
  • Cellular Senescence
  • Epithelium
  • Fibrosis
  • Flow Cytometry
  • Kidney
  • Kidney Tubules, Proximal
  • Mitophagy
  • Protein Kinases
  • Quercetin
  • Rats
  • Sirtuin 1

Keywords

  • Fibrosis
  • Mitochondria
  • Mitophagy
  • Quercetin
  • Senescence


Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy.


Keywords

  • PI3K/Akt/mTOR pathway
  • PTEN
  • autophagy
  • bleomycin
  • cancer cell
  • premature senescence


miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.


MeSH Terms

  • Adaptor Proteins, Signal Transducing
  • Aging
  • Animals
  • Cell Line
  • Cells, Cultured
  • Down-Regulation
  • Humans
  • Male
  • Mesenchymal Stem Cells
  • Mice, Inbred C57BL
  • MicroRNAs
  • Mitophagy
  • Protein Interaction Maps
  • Protein Kinases
  • Up-Regulation

Keywords

  • Aging
  • Bone marrow MSCs
  • Mitophagy
  • miR-155


Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence.


MeSH Terms

  • Airway Remodeling
  • Asthma
  • Autophagy
  • Cellular Senescence
  • Disease Susceptibility
  • Environmental Exposure
  • Humans
  • Mitophagy
  • Oxidative Stress
  • Respiratory Mucosa

Keywords

  • asthma
  • autophagy
  • mitophagy
  • oxidative stress
  • senescence


PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation.


MeSH Terms

  • Aging
  • Cellular Senescence
  • Epithelial Cells
  • Humans
  • Idiopathic Pulmonary Fibrosis
  • PTEN Phosphohydrolase
  • Proto-Oncogene Proteins c-akt
  • Pulmonary Alveoli
  • Respiratory Mucosa

Keywords

  • aging
  • cellular senescence
  • phosphatase and tension homolog deleted on chromosome ten
  • protein kinase B
  • pulmonary fibrosis

PTH[править]

Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox.


Keywords

  • aging
  • frailty
  • vitamin D
  • vitamin D receptor


Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age.


MeSH Terms

  • Aging
  • Animals
  • Calcium-Regulating Hormones and Agents
  • Cells, Cultured
  • Disease Models, Animal
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Osteoarthritis
  • Osteogenesis
  • Parathyroid Hormone
  • Temporomandibular Joint

Keywords

  • cellular senescence
  • cyclin-dependent kinase inhibitor P16INK4A
  • marrow mesenchymal stem cells
  • osteoarthritis
  • temporomandibular joint disorders

PTP4A3[править]

Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease.


Keywords

  • 3D microvascular network
  • blood-brain barrier
  • endothelium
  • human serum
  • vascular aging

PTPN11[править]

Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array.


Keywords 

         SowPro90
  • Bayes interval mapping
  • custom genotyping array
  • gilts
  • puberty
  • reproductive longevity

PTTG1[править]

[Down-regulated PTTG1 expression promotes the senescence of human prostate cancer LNCaP-AI].


MeSH Terms

  • Cell Line, Tumor
  • Cell Proliferation
  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant
  • RNA, Small Interfering
  • Securin
  • beta-Galactosidase

Keywords

  • LNCaP-AI cell


  • castration-resistant prostate cancer
  • cellular senescence
  • pituitary tumor-transforming gene-1
  • prostate cancer

PTX3[править]

Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects.


Keywords

  • aging
  • endurance training
  • exercise
  • inflammation
  • oxidative stress
  • pentraxin 3
  • toll-like receptor 4


Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study.


Keywords

  • Biomarkers
  • Cognitive aging
  • Inflammation
  • Sex differences

PUM1[править]

Identification of reference genes for RT-qPCR data normalisation in aging studies.


MeSH Terms

  • Aging
  • Algorithms
  • Gene Expression Profiling
  • Genes, Essential
  • Humans
  • Real-Time Polymerase Chain Reaction
  • Software

RACK1[править]

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Female
  • Gene Expression Regulation, Developmental
  • Male
  • Mice
  • Proteomics
  • Ribosomal Proteins

Keywords

  • aging
  • mass spectrometry
  • neuronal tissues
  • ribosome
  • translation

RAF1[править]

Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during RAF1 oncogene-induced senescence.


Keywords

  • INK4 locus
  • Non-coding RNAs
  • Polycomb proteins
  • circular RNAs
  • gene expression regulation
  • oncogene-induced senescence

RAG1[править]

T cell senescence accelerates Angiotensin II-induced target organ damage.


Keywords

  • T cell
  • angiotensin II
  • cardiorenal dysfunction
  • senescence

RAG2[править]

Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation.


Keywords

  • aging
  • glucose transporters
  • human
  • metabolism
  • mice
  • phosphate transporters
  • thymus

RAN[править]

Rapid automatized naming (RAN): effects of aging on a predictor of reading skill.


Keywords

  • Aging
  • RAN
  • individual differences
  • naming
  • reading

RELB[править]

New control of the senescence barrier in breast cancer.


Keywords

  • CEBPB
  • Cellular senescence
  • PAK4
  • RELB
  • p21-activated kinase

REST[править]

[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors].


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Brain
  • Gene Expression
  • Gene Expression Regulation, Developmental
  • Humans
  • Neurodegenerative Diseases
  • Protein Biosynthesis
  • Repressor Proteins
  • Ribosomes

Keywords

  • aging
  • brain
  • gene expression
  • neurodegeneration
  • ribosome
  • translational fidelity


Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism.


MeSH Terms

  • Aging
  • Animals
  • Behavior, Animal
  • Blood Glucose
  • Body Weight
  • Brain
  • Brain-Derived Neurotrophic Factor
  • Cognitive Dysfunction
  • Diabetes Mellitus, Experimental
  • Exploratory Behavior
  • Male
  • Memory Disorders
  • Mice
  • Palmitic Acid
  • Repressor Proteins
  • Social Behavior
  • Spatial Memory
  • Stearic Acids

Keywords

  • 9-PAHSA
  • BDNF
  • Diabetes mellitus
  • REST


Increased REST to Optimize Life Span?


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Homeostasis
  • Longevity
  • Repressor Proteins
  • Signal Transduction

Keywords

  • life span
  • neuronal activity
  • neurotoxicity

RET[править]

Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis.


Keywords

  • Aging
  • Antioxidants
  • Exercise
  • Oxidative stress
  • Resistance exercise training


Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial.


Keywords

  • Aging
  • Muscle echo intensity
  • Muscle quality
  • Physical function
  • Resistance training


Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults.


Keywords

  • aging
  • hypertrophy
  • myonuclear domain
  • skeletal muscle


Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.


MeSH Terms

  • Adaptation, Physiological
  • Aged
  • Capillaries
  • Citrate (si)-Synthase
  • Exercise
  • Female
  • Humans
  • Hypertrophy
  • Male
  • Muscle Fibers, Skeletal
  • Muscle Proteins
  • Muscle, Skeletal
  • Resistance Training
  • Sarcopenia
  • Ubiquitin-Protein Ligases

Keywords

  • Aging
  • Capillary
  • Fiber cross-sectional area
  • Muscle hypertrophy
  • Muscle protein synthesis

REV1[править]

REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.


Keywords

  • Rev1
  • cell death
  • chemotherapy
  • senescence
  • translesion synthesis

RHEB[править]

The Rheb-TORC1 signaling axis functions as a developmental checkpoint.


MeSH Terms

  • Animals
  • Animals, Genetically Modified
  • Autophagy
  • CRISPR-Cas Systems
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Life Cycle Stages
  • Longevity
  • Mechanistic Target of Rapamycin Complex 1
  • Phosphotransferases (Alcohol Group Acceptor)
  • RNA Interference
  • RNA, Small Interfering
  • Ras Homolog Enriched in Brain Protein
  • Signal Transduction

Keywords

  • MTOR
  • MTORC1
  • Ral
  • RalGAP
  • TSC
  • Tuberous sclerosis complex

RHO[править]

Conditional reprogramming: next generation cell culture.


Keywords

  • 3T3-J2 fibroblast
  • AACR, American Association for Cancer Research
  • ACC, adenoid cystic carcinoma
  • AR, androgen receptor
  • CFTR, cystic fibrosis transmembrane conductance regulators
  • CR, conditional reprogramming
  • CYPs, cytochrome P450 enzymes
  • Conditional reprogramming
  • DCIS, ductal carcinoma in situ
  • ECM, extracellular matrix
  • ESC, embryonic stem cell
  • HCMI, human cancer model initiatives
  • HGF, hepatocyte growth factor
  • HNE, human nasal epithelial
  • HPV, human papillomaviruses
  • ICD, intracellular domain
  • LECs, limbal epithelial cells
  • NCI, National Cancer Institute
  • NGFR, nerve growth factor receptor
  • NSCLC, non-small cell lung cancer
  • NSG, NOD/SCID/gamma
  • PDAC, pancreatic ductal adenocarcinoma
  • PDX, patient derived xenograft
  • PP2A, protein phosphatase 2A
  • RB, retinoblastoma-associated protein
  • ROCK
  • ROCK, Rho kinase
  • SV40, simian virus 40 large tumor antigen
  • Senescence
  • UVB, ultraviolet radiation b
  • Y-27632
  • dECM, decellularized extracellular matrix
  • hASC, human adipose stem cells
  • hTERT, human telomerase reverse transcriptase
  • iPSCs, induction of pluripotent stem cells
  • ΔNP63α, N-terminal truncated form of P63α


SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.


MeSH Terms

  • Adult
  • Aging
  • Angiotensin-Converting Enzyme 2
  • Bronchi
  • COVID-19
  • Cells, Cultured
  • Chronic Disease
  • Coronavirus Infections
  • Epithelial Cells
  • Female
  • Gene Expression
  • Gene Expression Profiling
  • Germany
  • Goblet Cells
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • Reference Standards
  • Sequence Analysis, RNA
  • Serine Endopeptidases
  • Sex Characteristics
  • Single-Cell Analysis
  • Smoking
  • Tissue Banks

Keywords

FURIN

  • COVID-19
  • Human Cell Atlas
  • epithelial differentiation
  • respiratory tract

RICTOR[править]

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase.


MeSH Terms

  • Cellular Senescence
  • Endothelial Cells
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • MicroRNAs
  • Nerve Tissue Proteins
  • Phosphorylation
  • Protein Binding
  • Rapamycin-Insensitive Companion of mTOR Protein
  • Ribonucleoproteins
  • Telomeric Repeat Binding Protein 2
  • Ubiquitin-Protein Ligases

Keywords

  • Inflammation
  • MKRN1
  • Senescence
  • Senescence-associated secretory phenotype (SASP)
  • Telomeric repeat binding factor 2-interacting protein (TERF2IP)
  • p90RSK

RIF1[править]

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.


MeSH Terms

  • Aging
  • Animals
  • BRCA1 Protein
  • DNA Breaks, Double-Stranded
  • DNA Damage
  • Genomic Instability
  • Homologous Recombination
  • Mice
  • Mutation
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Rad51 Recombinase
  • Tumor Suppressor p53-Binding Protein 1
  • Ubiquitin-Protein Ligases

Keywords

  • 53BP1
  • BRCA1
  • PARPi
  • aging
  • cancer
  • homologous recombination
  • resection
  • shieldin

RIPK1[править]

Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3.


Keywords

  • aging
  • cell biology
  • mouse
  • necroptosis
  • protein kinase
  • reproductivity
  • testis


Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.


Keywords

  • Aurintricarboxylic acid
  • Cartilage trauma
  • Hypertrophy
  • Regulated cell death
  • Senescence
  • Terminal complement complex

RIPK3[править]

Metformin mediates cardioprotection against aging-induced ischemic necroptosis.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • GTPase-Activating Proteins
  • Humans
  • Hypoglycemic Agents
  • Imidazoles
  • Indoles
  • Male
  • Metformin
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardium
  • Myocytes, Cardiac
  • Necroptosis
  • Protein Binding
  • RNA, Small Interfering
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Reperfusion Injury
  • Sequestosome-1 Protein

Keywords

  • aging
  • autophagy defect
  • cardioprotection
  • ischemia/reperfusion injury
  • metformin
  • myocardial necroptosis

RNF10[править]

Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.


Keywords

  • E3 ubiquitin ligase
  • RNF10
  • immunosenescence
  • inflammation
  • macrophages

RNF13[править]

The effects of environmental stressors on candidate aging associated genes.


Keywords

  • Aging
  • Candidate genes
  • Environmental factors
  • Epigenetic
  • Hypo/hyper methylated (methylation)

ROCK2[править]

Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats.


Keywords

  • Aging
  • Insulin resistance
  • Physical exercise
  • Rho-kinase (ROCK)

RPE[править]

Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.


Keywords

  • Aging
  • Human embryonic stem cell
  • Human pluripotent stem cell
  • Retinal pigment epithelium
  • Single-cell RNA sequencing


Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.


Keywords

  • aging
  • cardiorespiratory
  • maximum test
  • rate of perceived exertion
  • water aerobics
  • water-based exercises


Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging.


Keywords

  • Per2luc
  • aging
  • circadian
  • mice
  • photoreceptors
  • retinal pigment epithelium


An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy.


Keywords

  • AMD
  • RPE
  • aging
  • autofluorescence
  • autophagy
  • diet
  • lysosomes
  • oxidized POS
  • proteolysis
  • retina


Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.


Keywords

  • aging
  • exercise
  • hypertension


Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.


MeSH Terms

  • Aged
  • Aging
  • Brain
  • Female
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neurodegenerative Diseases
  • Organ Size
  • Retinal Photoreceptor Cell Outer Segment
  • Retinal Pigment Epithelium
  • Tomography, Optical Coherence


Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1.


Keywords

  • Aging
  • DJ-1
  • Oxidative stress
  • Retina
  • Retinal pigment epithelium
  • Sodium iodate


Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.


MeSH Terms

  • Aging
  • Animals
  • Electrophysiological Phenomena
  • Electroretinography
  • Light
  • Mice
  • Retinal Pigment Epithelium


High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.


Keywords

  • age-related macular degeneration
  • aging
  • apolipoprotein
  • complement
  • complement factor H
  • glycosaminoglycan
  • heparan sulfate
  • heparan sulfate proteoglycans
  • high-density lipoprotein (HDL)
  • lipoprotein
  • oligosaccharide
  • retinal degeneration
  • retinal pigmented epithelium


MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.


Keywords

  • AMD
  • Mtor
  • aging
  • lipid
  • metabolism


[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.


Keywords

  • cellular senescence
  • eye fatigue
  • inflammation
  • lactic acid bacteria
  • probiotics
  • retina


Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.


Keywords

  • Age-related macular degeneration
  • Aging
  • Differentiation
  • Innate immunity
  • RNA sequencing
  • Smoking


Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.


MeSH Terms

  • Adult
  • Aging
  • Cell Movement
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Ophthalmoscopy
  • Retinal Dystrophies
  • Retinal Pigment Epithelium
  • Retrospective Studies
  • Slit Lamp Microscopy
  • Tomography, Optical Coherence


Exosomal MiRNA Transfer between Retinal Microglia and RPE.


Keywords

  • RPE
  • aging
  • exosome
  • inflammation
  • microglia


Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.


Keywords

  • Age-related macular degeneration
  • Aging
  • Cones
  • Dark adaptation
  • Light sensitivity
  • Macula
  • Quantitative autofluorescence
  • Retina
  • Rods
  • Spectral domain optical coherence tomography


Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.


Keywords

  • Age-related macular degeneration
  • Aggregation
  • Aging
  • Autophagy
  • Clearance
  • Degeneration
  • Mitochondria
  • Mitophagy
  • Retina
  • Retinal pigment epithelium


CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.


Keywords

  • RPE disorganization
  • aging
  • choroid
  • choroidal macrophage
  • choroidal vasculature
  • immunology
  • inflammation
  • mouse
  • neuroscience


Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.


Keywords

  • Extracellular vesicles
  • Oxidative stress
  • Phagocytosis
  • RPE cell Dysfunction
  • RPE cell-Derived microparticles (RMPs)
  • Retinal pigment epithelial cell (RPE)
  • Senescence


Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).


Keywords

  • Aerobic capacity
  • Aerobic training
  • Aging
  • Aquatic exercise
  • Interval exercise
  • Muscle echo intensity
  • Muscle strength
  • Muscle thickness


Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.


Keywords

  • aging
  • recollection and familiarity
  • retrieval practice
  • temporal dynamics
  • testing effect


A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists


MeSH Terms

  • Adult
  • Aging
  • Bicycling
  • Heart Rate
  • High-Intensity Interval Training
  • Humans
  • Middle Aged
  • Perception
  • Physical Exertion

Keywords

  • age
  • endurance training
  • high-intensity interval training
  • older athlete


Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.


MeSH Terms

  • Animals
  • Circadian Rhythm
  • Epithelial Cells
  • Eye Proteins
  • Humans
  • Mice
  • Phagocytosis
  • Photoreceptor Cells, Vertebrate
  • RNA Splicing Factors
  • Retinal Pigment Epithelium
  • Retinitis Pigmentosa

Keywords

  • Aging
  • Cellular stress
  • Circadian rhythm
  • Metabolism
  • PRPF
  • Phagocytosis
  • Retinal pigment epithelium
  • Retinitis pigmentosa
  • Splicing factors


AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.


MeSH Terms

  • AMP-Activated Protein Kinases
  • Animals
  • DNA Damage
  • DNA, Mitochondrial
  • Disease Models, Animal
  • Gene Dosage
  • Metformin
  • Mice
  • Oxidative Stress
  • Retina
  • Retinal Degeneration
  • Retinitis Pigmentosa

Keywords

  • AMPK
  • Adenosine monophosphate-activated protein kinase
  • Aging
  • Glycolysis
  • Metabolism
  • Neuroprotection
  • Retina


Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.


Keywords

  • Bruch's membrane
  • age-related macular degeneration
  • aging
  • induced pluripotent stem cells
  • nonenzymatic nitration
  • retinal pigment epithelium


Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.


MeSH Terms

  • Amyloid beta-Peptides
  • Animals
  • Apoptosis
  • Autophagy
  • Cells, Cultured
  • Docosahexaenoic Acids
  • Extracellular Matrix
  • Fatty Acids, Omega-3
  • Gene Expression Regulation
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Photoreceptor Cells
  • Retina
  • Retinal Pigment Epithelium
  • Young Adult

Keywords

  • SASP
  • age-related macular degeneration
  • p16
  • retinal pigment epithelial cells
  • senescence gene program


Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.


MeSH Terms

  • Aging
  • Animals
  • Basement Membrane
  • Bruch Membrane
  • Exocytosis
  • Humans
  • Lysosomal-Associated Membrane Protein 2
  • Lysosomes
  • Macular Degeneration
  • Mice
  • Mice, Knockout
  • Phagocytosis
  • Retina
  • Retinal Pigment Epithelium

Keywords

  • LAMP2
  • aging
  • lysosome
  • retinal degeneration


Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.


MeSH Terms

  • Age Factors
  • Animals
  • Biomarkers
  • Choroid
  • Disease Models, Animal
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Lipofuscin
  • Macular Degeneration
  • Male
  • Melanins
  • Melanosomes
  • Mice
  • Mice, Knockout
  • Optical Imaging
  • Oxidation-Reduction
  • Oxidative Stress
  • Protein Transport
  • Retinal Pigment Epithelium
  • Tomography, Optical Coherence

Keywords

  • Aging
  • Lipofuscin
  • Melanin
  • Melanolipofuscin
  • Oxidative stress


Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.


Keywords

  • Aging
  • computational modeling
  • individual differences
  • reinforcement learning
  • working memory


Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.


MeSH Terms

  • Aging
  • Angiotensin II
  • Animals
  • Cells, Cultured
  • Electroretinography
  • Humans
  • Ligands
  • Lipopolysaccharides
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Oligopeptides
  • Rats
  • Reactive Oxygen Species
  • Receptors, G-Protein-Coupled
  • Retina

Keywords

  • Alamandine
  • Angiotensin-(1–7)
  • Mas-related G protein-coupled receptor D
  • Rennin-angiotensin system
  • Retina

RPIA[править]

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.


MeSH Terms

  • Aldose-Ketose Isomerases
  • Animals
  • Cell Line
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p16
  • Gene Knockdown Techniques
  • Humans
  • Male
  • Mechanistic Target of Rapamycin Complex 1
  • Mice, SCID
  • Nucleotides
  • Pentose Phosphate Pathway
  • Protein Biosynthesis

Keywords

  • BRAF
  • cancer metabolism
  • cell cycle
  • melanoma
  • nevi
  • pancreatic cancer
  • pentose phosphate pathway
  • ribonucleotide reductase M2
  • ribose-5-phosphate isomerase A
  • senescence

RPS19BP1[править]

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence.


Keywords

  • Oxidative stress
  • Pinellia ternata
  • SIRT1
  • Senescence

RTEL1[править]

Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Mendelian Randomization Analysis
  • Middle Aged
  • Risk Factors
  • Telomere Homeostasis

Keywords

  • TERT
  • UK Biobank
  • anti-aging
  • cellular senescence
  • centenarians
  • frailty
  • longevity
  • sarcopenia

RXFP3[править]

The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.


MeSH Terms

  • Camptothecin
  • Computational Biology
  • DNA Damage
  • Felodipine
  • GTPase-Activating Proteins
  • Gene Expression Regulation
  • Gene Regulatory Networks
  • HEK293 Cells
  • Humans
  • Oxidative Stress
  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • Topoisomerase I Inhibitors

Keywords

  • DNA damage
  • GPCR
  • aging
  • relaxin 3
  • relaxin family peptide 3 receptor

S100A4[править]

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice.


MeSH Terms

  • Alarmins
  • Animals
  • Cytokines
  • Exosomes
  • Lung
  • Mesenchymal Stem Cells
  • Mice
  • Mitochondria
  • Mitophagy
  • Oxidative Phosphorylation
  • Smoke
  • Tobacco

Keywords

  • COPD
  • Cellular Senescence
  • Exosomes
  • Mesenchymal stem cells
  • Mitochondria

S100A9[править]

Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease.


Keywords

  • Cigarette smoke
  • S100A9
  • aging
  • kinase
  • pulmonary function


Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Animals
  • Behavior, Animal
  • Brain
  • Disease Models, Animal
  • Enzyme Inhibitors
  • Epigenesis, Genetic
  • Female
  • Gene Expression
  • Hippocampus
  • Histone Demethylases
  • Humans
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Monoamine Oxidase Inhibitors
  • Oxadiazoles
  • Rats
  • Rats, Sprague-Dawley


Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Calgranulin B
  • Case-Control Studies
  • Cell Line
  • Cells, Cultured
  • Cellular Reprogramming
  • Cellular Senescence
  • Female
  • Humans
  • Inflammasomes
  • Interleukin-1beta
  • Male
  • Mesenchymal Stem Cells
  • Middle Aged
  • Myelodysplastic Syndromes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Reactive Oxygen Species
  • Signal Transduction
  • Stem Cell Niche
  • Toll-Like Receptor 4
  • Up-Regulation
  • Young Adult

Keywords

  • NLRP3
  • S100A9
  • cellular senescence
  • mesenchymal stromal cells
  • myelodysplastic syndromes


S100A9 extends lifespan in insulin deficiency.


MeSH Terms

  • Animals
  • Calgranulin B
  • Diabetes Mellitus, Experimental
  • Diphtheria Toxin
  • Fatty Acids
  • Humans
  • Hyperglycemia
  • Insulin
  • Leptin
  • Liver
  • Longevity
  • Male
  • Mice
  • Mice, Knockout
  • Oxidation-Reduction
  • Signal Transduction
  • Streptozocin
  • Toll-Like Receptor 4

S100B[править]

Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage.


Keywords

  • Aging
  • LDH
  • S100B
  • edema
  • oxygen-glucose deprivation

S1PR1[править]

Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair.


Keywords

  • aging
  • endothelial cell
  • fibrosis
  • kidney repair
  • lipoprotein
  • lung regeneration
  • sphingosine-1-phosphate receptor
  • vascular barrier
  • vascular niche

SAG[править]

WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana.


Keywords

WRKY42

  • Arabidopsis
  • leaf senescence
  • reactive oxygen species
  • salicylic acid


Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood.


MeSH Terms

  • Adult Stem Cells
  • Aging
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors
  • Cell Differentiation
  • Ear, Inner
  • Embryo, Nonmammalian
  • Ganglia, Sensory
  • Gene Expression Regulation, Developmental
  • Hair Cells, Auditory
  • Larva
  • Nerve Tissue Proteins
  • Nestin
  • Neural Stem Cells
  • Neurogenesis
  • Sensory Receptor Cells
  • Stem Cell Niche
  • Zebrafish

Keywords

  • Inner ear
  • Neuronal stem cells
  • PNS
  • Zebrafish

SAT1[править]

Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action.


Keywords

  • Acetylation
  • SAT1
  • aging
  • autophagy
  • copper
  • metabolomics
  • obesity
  • spermidine

SATB1[править]

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons.


MeSH Terms

  • Aging
  • Animals
  • Cells, Cultured
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • Dopaminergic Neurons
  • Epigenetic Repression
  • Gene Knockdown Techniques
  • Humans
  • Matrix Attachment Region Binding Proteins
  • Mice
  • Mice, Knockout
  • Mitosis
  • Parkinson Disease
  • Protein Binding

Keywords

  • Parkinson’s disease
  • SATB1
  • cellular senescence
  • dopamine
  • neurodegeneration
  • neuroinflammation
  • p21
  • senolytics
  • stem cells
  • transcriptomics

SCD[править]

Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial.


Keywords

  • Aging
  • Decision-making
  • Mild cognitive impairment
  • Subjective cognitive decline
  • Transcranial direct current stimulation
  • Transfer
  • Working memory


Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline.


Keywords

  • Alzheimer’s disease
  • aging
  • blood pressure
  • mild cognitive impairment
  • subjective cognitive decline


Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline.


Keywords

  • aging
  • cognitive impairment
  • neuropsychological assessment


Subjective cognitive decline as a predictor of future cognitive decline: a systematic review.


Keywords

  • Alzheimer disease.
  • aging
  • cognition
  • cognitive dysfunction
  • dementia


Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study.


Keywords

  • Aging
  • Functional assessment
  • Geriatric assessment
  • Geriatrics
  • Older adults
  • Sickle cell


Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany.


Keywords

  • Germany
  • cognitive aging
  • cognitive complaints
  • cohort study
  • prevalence
  • subjective cognitive decline


SC411 treatment can enhance survival in a mouse model of sickle cell disease.


Keywords

  • Aging
  • Cerebral blood flow
  • Docosahexaenoic acid
  • Neuroinflammation
  • Sickle cell disease
  • Working memory


DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response.


Keywords

  • DNA longevity
  • sperm DNA damage
  • sperm DNA dynamics
  • sperm DNA fragmentation
  • sperm chromatin dispersion test


Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • Brain aging
  • Cognitive decline
  • Cognitive testing
  • Longitudinal studies
  • Psychometric cognition


Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project.


Keywords

  • Aging
  • Biochemistry
  • Cognition
  • Dementia
  • Geriatric medicine


Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits.


Keywords

  • activity participation
  • aging
  • daily functioning
  • metamemory
  • subjective cognitive decline


Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score.


Keywords

  • Aging
  • Electrical risk score
  • Gender
  • Mortality
  • QTc
  • Repolarization phase
  • T peak-tend interval


Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017.


Keywords

  • Aging
  • Chronic disease
  • Cognitive dysfunction
  • Dementia


Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline.


Keywords

  • Alzheimer’s disease
  • aging
  • biomarkers
  • cerebrovascular health
  • signal variability
  • subjective cognitive decline
  • white matter


Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Anemia, Sickle Cell
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Forecasting
  • Humans
  • Income
  • Infant
  • Life Expectancy
  • Male
  • Middle Aged
  • Models, Statistical
  • Quality-Adjusted Life Years
  • United States
  • Young Adult


Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?


Keywords

  • Compostela aging study
  • cluster analysis
  • cognitive aging
  • dementia
  • mild cognitive impairment
  • screening and diagnosis
  • subjective cognitive complaints


Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline.


MeSH Terms

  • Aged
  • Aging
  • Brain Waves
  • Cerebral Cortex
  • Cognitive Dysfunction
  • Cortical Synchronization
  • Female
  • Humans
  • Magnetoencephalography
  • Male
  • Memory, Short-Term
  • Task Performance and Analysis

Keywords

  • Alzheimer’s disease (AD)
  • Induced oscillatory activity
  • magnetoencephalography (MEG)
  • mild cognitive impairment (MCI)
  • subjective cognitive decline (SCD)
  • working memory (WM)


Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Corpus Callosum
  • Diffusion Tensor Imaging
  • Female
  • Frontal Lobe
  • Functional Laterality
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory Disorders
  • Middle Aged
  • Nerve Fibers
  • Neuropsychological Tests
  • Retrospective Studies
  • Surveys and Questionnaires
  • Taiwan

Keywords

  • Aging
  • Alzheimer’s disease
  • Cognitive complaints
  • Diffusion tensor imaging
  • Lateralization
  • Prospective memory
  • Tract-based spatial statistics

SCN2A[править]

Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age.


MeSH Terms

  • Aging
  • Animals
  • Autism Spectrum Disorder
  • Gene Knockout Techniques
  • Haploinsufficiency
  • Memory
  • Mice
  • NAV1.2 Voltage-Gated Sodium Channel
  • Phenotype
  • Spatial Learning

SCN2B[править]

MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Transgenic
  • MicroRNAs
  • Voltage-Gated Sodium Channel beta-2 Subunit

SCO1[править]

Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans.


Keywords

  • Caenorhabditis elegans
  • Energy metabolism
  • Longevity
  • TaqMan real-time PCR
  • p53/CEP-1

SDC1[править]

Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/SDC1 axis.


Keywords

  • Atherosclerosis
  • MiR-665
  • SDC1
  • olmesartan
  • vascular smooth muscle cell senescence


Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis.


Keywords

  • FGFR1
  • SDC1
  • cellular senescence
  • endocytosis
  • heparan sulfation

SDHB[править]

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study.


Keywords

  • aging
  • biomarkers
  • exosomes
  • mitochondrial dynamics
  • mitochondrial quality control
  • mitochondrial-derived vesicles
  • mitochondrial-lysosomal axis
  • mitophagy

SDS[править]

Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.


Keywords

  • Aging skeletal muscle
  • Morphometric analysis
  • Myosin heavy chain
  • Semiautomatic muscle analysis
  • Skeletal muscle


Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri.


Keywords

  • Aging
  • Annual fish
  • Lifespan
  • Nothobranchius
  • Salidroside


Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow.


MeSH Terms

  • Aging
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Longevity
  • Protein Aggregates
  • Proteome
  • Proteomics
  • Workflow


Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect.


Keywords

  • aging
  • myofibrillar protein
  • proteomics
  • resistance training
  • sarcoplasmic protein


Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Catalase
  • Drugs, Chinese Herbal
  • Galactose
  • Humans
  • Kidney
  • Liver
  • Male
  • Malondialdehyde
  • Mice
  • Mice, Inbred ICR
  • Molecular Weight
  • Oxidative Stress
  • Plant Proteins
  • Plant Roots
  • Superoxide Dismutase

Keywords

  • Antioxidant activity
  • D-galactose
  • Oxidative damage
  • Protein composition
  • Radix isatidis protein


[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster].


MeSH Terms

  • Animals
  • Apoptosis
  • Drosophila melanogaster
  • Longevity
  • Metal Nanoparticles
  • Oregon
  • Silver

Keywords

  • Drosophila melanogaster
  • apoptosis
  • protein expression
  • silver nanoparticles


Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study.


MeSH Terms

  • Adolescent
  • Aging
  • Behavior Therapy
  • Cognitive Behavioral Therapy
  • Female
  • Humans
  • Male
  • Weight Loss
  • Weight Reduction Programs
  • Young Adult

Keywords

  • adolescents
  • behavioral weight loss
  • controlled trial
  • emerging adults
  • obesity
  • quality of life

SELENBP1[править]

A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Cytoplasm
  • Drug Resistance
  • Gene Expression Regulation
  • Humans
  • Longevity
  • Membrane Proteins
  • Oxidative Stress
  • Paraquat
  • Selenious Acid
  • Selenium-Binding Proteins
  • Structural Homology, Protein

Keywords

  • Caenorhabditis elegans
  • Lifespan
  • Selenium-binding protein
  • Stress signaling

SELENOK[править]

Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data.


Keywords

  • Female fertility
  • Ovarian aging
  • Selenium
  • Selenoprotein K
  • Selenoprotein M

SENP6[править]

Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.


Keywords

  • Pax6
  • SUMO1
  • SUMO2/3
  • aging
  • apoptosis
  • cataract
  • de-sumoylation enzymes (SENPs)
  • sumoylation ligases

SERPINE1[править]

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes.


Keywords

  • Endothelial aging
  • Endothelial cells
  • HtrA4
  • Preeclampsia
  • Senescence

SESN2[править]

Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i]SESN2[/i] Have a Role in Age-related Different Prognoses?


Keywords

  • Papillary thyroid cancer
  • SESN2
  • aCGH
  • deletion
  • senescence

SFN[править]

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis.


Keywords

  • Aging
  • Hormesis
  • Inflammation
  • Neuroprotection
  • Nrf2
  • Sulforaphane


Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice.


Keywords

  • aging
  • biomarkers
  • gut microbiome
  • metabolome
  • sulforaphane


Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis.


Keywords

  • Coculture system
  • Collagen homeostasis
  • Melanogenesis
  • Particulate matter 2.5
  • Premature skin aging
  • Sulforaphane


Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.


Keywords

  • ROS
  • autophagy
  • exosome
  • senescence
  • sulforaphane

SFPQ[править]

Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis.


Keywords

  • IL-8
  • NORAD
  • cell apoptosis
  • cell senescence
  • ox-LDL

SGK1[править]

Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells.


Keywords

  • AKT
  • EZH2
  • aging
  • mTOR
  • p53

SHBG[править]

Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study.


Keywords

  • aging
  • cardiovascular events
  • men
  • testosterone


Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.


Keywords

  • aging
  • atherosclerosis
  • carotid artery
  • hormones
  • women


Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years.


MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Aging
  • Androgens
  • Biomarkers
  • Bone Density
  • Bone Remodeling
  • Bone and Bones
  • Collagen Type I
  • Dehydroepiandrosterone Sulfate
  • Estradiol
  • Humans
  • Male
  • Middle Aged
  • Parathyroid Hormone
  • Peptide Fragments
  • Peptides
  • Procollagen
  • Sex Hormone-Binding Globulin
  • Testosterone

Keywords

  • aging men
  • biochemical bone markers
  • levels of androgens


Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Community-Based Participatory Research
  • Cross-Sectional Studies
  • Dehydroepiandrosterone
  • Estrone
  • Female
  • Follow-Up Studies
  • Humans
  • Obesity
  • Overweight
  • Prognosis
  • Testosterone

SHD[править]

Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation.


MeSH Terms

  • Activities of Daily Living
  • Aged
  • Aged, 80 and over
  • Cognition
  • Cognitive Dysfunction
  • Cohort Studies
  • Disabled Persons
  • Female
  • Health Status
  • Hearing Loss
  • Humans
  • Longevity
  • Longitudinal Studies
  • Male
  • Mental Status and Dementia Tests
  • Odds Ratio
  • Self Report
  • Social Isolation

Keywords

  • Cognitive impairment
  • Older people
  • Physical disability
  • Self-reported hearing difficulty
  • Social isolation

SHH[править]

Recent advances in SHH medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment.


MeSH Terms

  • Animals
  • Cerebellar Neoplasms
  • Cerebellum
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma
  • Mice
  • Tumor Microenvironment

Keywords

  • Medulloblastoma
  • Sonic hedgehog
  • cell senescence
  • tumor microenvironment
  • tumor progression

SI[править]

Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation.


Keywords

  • Aging
  • Biomarkers
  • Sex differences
  • Social isolation
  • Stroke
  • miRNAs


Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review.


MeSH Terms

  • Aging
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Female
  • Fingers
  • Heart Rate
  • Humans
  • Male
  • Microcirculation
  • Photoplethysmography
  • Vascular Stiffness

Keywords

  • cardiovascular disease
  • heart rate
  • photoplethysmography
  • reflection index
  • second derivative of photoplethysmography
  • stiffness index


Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study.


Keywords

  • elderly
  • geriatrics
  • palliative medicine


Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Depression
  • Diet, Mediterranean
  • Healthy Aging
  • Humans
  • Multimorbidity
  • Surveys and Questionnaires

Keywords

  • Aging
  • Depressive symptoms
  • Mediterranean diet
  • Mental health
  • Multimorbidity


Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults.


Keywords

  • accelerometry
  • aging
  • health
  • social well-being
  • volunteering


The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults.


Keywords

  • Chinese American
  • Social support
  • aging
  • negative social interaction
  • suicidal ideation


Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older.


MeSH Terms

  • Aged, 80 and over
  • Aging
  • Brain
  • Cellular Senescence
  • Cerebral Arteries
  • Cerebral Small Vessel Diseases
  • Female
  • Humans
  • Male
  • White Matter

Keywords

  • Brain aging
  • Cerebrovascular disease
  • Senescence
  • Small vessel disease

SIK3[править]

Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.


Keywords

  • Age-related phenotypes
  • Aging
  • Genome-wide association studies
  • Health span
  • Life span
  • Pleiotropy

SIRT1[править]

Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.


Keywords

  • NO
  • SIRT1
  • anthocyanins
  • eNOS deacetylation
  • senescence


Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.


Keywords

  • Aging
  • neurodegenerative diseases
  • neuroprotective
  • sirtuin
  • sirtuin activators
  • sirtuin inhibitors


Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.


Keywords

  • Cellular senescence
  • Diabetes
  • Diabetes complications
  • Endothelial cells
  • Garcinia mangostana
  • Hyperglycemia
  • Mangostin
  • Metabolic syndrome


SIRT1 Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.


Keywords

  • CRISPR/dCas9
  • SIRT1
  • corneal endothelial cells
  • senescence


Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases.


Keywords

  • SIRT1
  • SIRT1 activators
  • calorie restriction
  • senescence
  • vascular diseases
  • vascular smooth muscle cells


6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing SIRT1 and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.


Keywords

  • 6,4′-dihydroxy-7-methoxyflavanone
  • Akt
  • Oxidative stress
  • Premature senescence
  • SIRT1


Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through SIRT1 activation and AKT/mTOR pathway inhibition.


Keywords

  • AKT/mTOR signaling pathway
  • Antioxidant: SIRT1
  • Cellular senescence
  • Isoparvifuran


SIRT1 Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.


Keywords

  • 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside
  • SIRT1
  • human umbilical vein cells
  • hydrogen peroxide
  • senescence


The Role of Sirtuins in Kidney Diseases.


Keywords

  • acute kidney injury
  • aging kidney
  • chronic kidney disease
  • diabetic nephropathy
  • kidney
  • sirtuins


The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.


Keywords

  • Cellular senescence
  • Elderly
  • Resistance training


Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach.


Keywords

  • SIRT1
  • asthma
  • cellular senescence
  • exacerbations
  • virus infection


Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.


Keywords

  • Resveratrol
  • SIRT1
  • Senescence
  • Toxicity


Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/SIRT1-FOXA3-Beclin1 pathway.


Keywords

  • Beclin1
  • Endothelial cells
  • FOXA3
  • Glucose restriction
  • Proliferation
  • Senescence


Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.


Keywords

  • Sirtuin 1
  • alveolar epithelial cells
  • cellular senescence
  • chronic obstructive pulmonary disease
  • cigarette smoking


Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts.


Keywords

  • human dermal fibroblast
  • latifolin
  • mammalian target of rapamycin
  • oxidative stress
  • senescence
  • silent information regulator 1


SRT1720-induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.


Keywords

  • SIRT1
  • SRT1720
  • VSMC senescence
  • p-AMPK (Ser485)
  • telomere length


miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.


Keywords

  • PMOP
  • aging
  • inflammation
  • miR-128
  • osteoclastogenesis
  • ovariectomy


Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.


Keywords

  • CD28nullCD8+ T and NKT-like cells
  • COPD
  • IFNγ and TNFα
  • SIRT1
  • lymphocyte senescence


Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.


Keywords

  • Aging
  • Ashwagandha
  • Circadian clock
  • NRF2
  • SCN
  • SIRT1


The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Biomarkers
  • Blood Pressure
  • Cardiovascular Diseases
  • Case-Control Studies
  • Diabetes Complications
  • Echocardiography
  • Female
  • Glucuronidase
  • Heart Ventricles
  • Humans
  • Kidney
  • Kidney Failure, Chronic
  • Male
  • Middle Aged
  • Renal Dialysis
  • Sirtuin 1
  • Stroke Volume

Keywords

  • chronic kidney disease
  • hemodialysis
  • sirtuin1
  • αKlotho


Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.


Keywords

  • Cellular senescence
  • DNMT1
  • SIRT1
  • extracellular vesicles
  • microRNAs


Spatiotemporal gating of SIRT1 functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.


MeSH Terms

  • Acetylglucosamine
  • Aging
  • Animals
  • Fasting
  • Gluconeogenesis
  • Glycosylation
  • HEK293 Cells
  • Homeostasis
  • Humans
  • Hyperglycemia
  • Insulin Resistance
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Sirtuin 1
  • Spatio-Temporal Analysis

Keywords

  • PGC1α
  • fed–fast cycle
  • gluconeogenesis
  • insulin signaling
  • ubiquitinylation


Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of SIRT1.


Keywords

  • SIRT1
  • cell senescence
  • homocysteine
  • hydrogen sulfide


SIRT1 and aging related signaling pathways.


Keywords

  • Aging
  • Deacetylate
  • NAD(+)
  • SIRT1
  • Signaling pathways


Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of SIRT1 signaling.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Apoptosis
  • Brain
  • Drug Administration Schedule
  • Galactose
  • Gene Expression Regulation
  • Inflammation
  • Injections, Intraperitoneal
  • Injections, Subcutaneous
  • Interleukin-6
  • Male
  • Mice
  • Mitochondria
  • Neurons
  • Nitric Oxide
  • Oxidative Stress
  • Proto-Oncogene Proteins c-bcl-2
  • Reactive Oxygen Species
  • Serotonin 5-HT3 Receptor Antagonists
  • Sirtuin 1
  • Tropisetron
  • Tumor Necrosis Factor-alpha
  • bcl-2-Associated X Protein

Keywords

  • Aging
  • Brain
  • Neurotoxicity
  • Sirtuin 1
  • Tropisetron
  • d-galactose


Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.


Keywords

  • Aging
  • Geroscience
  • Mitochondria dysfunction
  • Transcriptomics
  • Vascular cognitive impairment


Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.


MeSH Terms

  • Acetylation
  • Animals
  • Benzamides
  • Carbazoles
  • Cellular Senescence
  • Collagen Type I
  • Down-Regulation
  • Embryo, Mammalian
  • Fibroblasts
  • HEK293 Cells
  • Heterocyclic Compounds, 4 or More Rings
  • Humans
  • Mice
  • Mutation
  • Naphthols
  • Primary Cell Culture
  • Promoter Regions, Genetic
  • RNA, Small Interfering
  • Resveratrol
  • Sirtuin 1
  • Trans-Activators

Keywords

  • Collagen type I
  • Fibroblast
  • Lysine deacetylation
  • Post-translational modification
  • Senescence
  • Transcriptional regulation


Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 Levels Improving Cognition in Aged Rats.


MeSH Terms

  • Age Factors
  • Animals
  • Behavior, Animal
  • Biogenic Monoamines
  • Catechin
  • Cognition
  • Cognitive Aging
  • Corpus Striatum
  • Hippocampus
  • Male
  • Memory, Episodic
  • Memory, Short-Term
  • Neuroprotective Agents
  • Rats, Sprague-Dawley
  • Sirtuin 1
  • Time Factors

Keywords

  • NF-κB
  • RBAP46/48
  • SIRT1
  • brain aging
  • brain monoamine synthesis
  • catechin
  • green tea
  • memory


Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating SIRT1.


Keywords

  • SIRT1
  • angiotensin II
  • duck oil
  • nanoemulsion
  • senescence


Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence.


Keywords

  • Sirtuins
  • drug discovery
  • epigenetic modulators
  • senescence
  • stress response


Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.


MeSH Terms

  • A549 Cells
  • Alveolar Epithelial Cells
  • Apoptosis
  • Cellular Senescence
  • Humans
  • Hydrogen Sulfide
  • Mitochondria
  • Oxidative Stress
  • Sirtuin 1
  • Smoke
  • Tobacco
  • Up-Regulation

Keywords

  • alveolar epithelial cell
  • cigarette smoke extract
  • hydrogen sulfide
  • mitochondria injury
  • senescence


The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.


MeSH Terms

  • Adipokines
  • Caveolin 1
  • Cell Line, Tumor
  • Cellular Senescence
  • Chondrocytes
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cytoprotection
  • G1 Phase Cell Cycle Checkpoints
  • Humans
  • Interleukin-1beta
  • Plasminogen Activator Inhibitor 1
  • Sirtuin 1
  • Transcriptional Activation

Keywords

  • IL-1β
  • Omentin-1
  • SIRT-1
  • chondrocyte senescence


The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Caloric Restriction
  • Cell Line
  • Humans
  • NAD
  • Niacin
  • Sirtuins
  • beta-Galactosidase

Keywords

  • C. elegans
  • Hs68 cells
  • NAD+
  • calorie restriction mimetic
  • lifespan
  • nicotinic acid


Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.


Keywords

  • Alpha-mangostin
  • Diabetes
  • HUVEC
  • High glucose
  • SIRT1
  • Senescence


Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.


Keywords

  • Fear conditioning
  • SIRT1
  • aging
  • classically conditioned memory
  • hippocampus


Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aging
  • Aging, Premature
  • Educational Status
  • Epigenesis, Genetic
  • Female
  • Gene Expression Regulation, Enzymologic
  • Histones
  • Humans
  • Learning
  • Male
  • Middle Aged
  • Sirtuins
  • Young Adult


CO ameliorates endothelial senescence induced by 5-fluorouracil through SIRT1 activation.


MeSH Terms

  • Antioxidants
  • Carbon Monoxide
  • Cellular Senescence
  • Down-Regulation
  • Fluorouracil
  • Heme Oxygenase-1
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Nitric Oxide Synthase Type III
  • Reactive Oxygen Species
  • Sirtuin 1

Keywords

  • 5-Fluorouracil
  • Carbon monoxide
  • Endothelial senescence
  • Reactive oxygen species
  • SIRT1


Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression.


MeSH Terms

  • Aging
  • Animals
  • Argonaute Proteins
  • Cell Proliferation
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Fibrosis
  • Gene Deletion
  • Gene Expression Regulation
  • Glucose
  • Male
  • Mesangial Cells
  • Mice
  • MicroRNAs
  • RAW 264.7 Cells
  • RNA, Long Noncoding
  • Rats
  • Rats, Sprague-Dawley
  • Sirtuin 1

Keywords

  • diabetic nephropathy
  • fibrosis
  • lncRNA GAS5
  • proliferation


The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.


Keywords

  • PVAT
  • SIRT1
  • eNOS
  • vascular aging
  • vascular remodeling


Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.


Keywords

  • Abrus agglutinin
  • LAMP1
  • SIRT1
  • free fatty acid
  • lipophagy
  • reactive oxygen species
  • senescence


Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.


Keywords

  • CPAP
  • OSA
  • aging
  • cardiovascular
  • endothelium
  • exosomes
  • extracellular vesicles
  • intermittent hypoxia
  • oxidative stress
  • senescence


Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of SIRT1.


Keywords

  • SIRT1
  • autophagic flux
  • high glucose
  • hydrogen sulfide
  • neuronal senescence


Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Coumarins
  • Galactose
  • Male
  • Mice
  • Mice, Inbred ICR
  • MicroRNAs
  • PC12 Cells
  • Random Allocation
  • Rats
  • Signal Transduction
  • Sirtuin 1
  • TOR Serine-Threonine Kinases

Keywords

  • D-Gal
  • SIRT1/mTOR signal pathway
  • Urolithin A
  • aging
  • autophagy
  • miR-34a

SIRT2[править]

Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway.


Keywords

  • aging
  • histone acetylation
  • meiosis
  • melatonin
  • oocyte quality

SIRT3[править]

SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway.


Keywords

  • Endothelial senescence
  • High glucose
  • SIRT3
  • p53


Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.


Keywords

  • aging
  • arterial hypertension
  • buccal epithelium
  • melatonin
  • sirtuins


[i]SIRT3[/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair.


Keywords

  • O-hMSC transplantation
  • SIRT3
  • aging
  • gene modification
  • myocardial infarction
  • myocardial repair


17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.


Keywords

  • 17β-estradiol
  • Autophagy
  • SIRT3
  • Senescence


CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells.


Keywords

  • Antioxidant system
  • Mitochondria
  • Oxidative stress
  • Senescence
  • Vascular endothelial cell


Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime.


Keywords

  • aging
  • mitochondria
  • postmitotic cells
  • skeletal muscle
  • telomeres


Context-Dependent Roles for SIRT2 and SIRT3 in Tumor Development Upon Calorie Restriction or High Fat Diet.


Keywords

  • SIRT2
  • SIRT3
  • aging
  • calorie restriction
  • cancer
  • high fat diet


The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders.


MeSH Terms

  • Aging
  • Animals
  • Cardiovascular Diseases
  • Humans
  • Metabolic Diseases
  • Mitochondria
  • Neurodegenerative Diseases
  • Protein Isoforms
  • Sirtuin 3

Keywords

  • Age-related diseases
  • Deacetylation
  • Genetic manipulations
  • Mitochondria
  • Pharmacological modulators
  • Sirtuins

SIRT5[править]

Lysine malonylation and propionylation are prevalent in human lens proteins.


MeSH Terms

  • Aging
  • Animals
  • Blotting, Western
  • Chromatography, Liquid
  • Crystallins
  • Cytoskeletal Proteins
  • Cytosol
  • Epithelial Cells
  • Humans
  • Immunohistochemistry
  • Lens, Crystalline
  • Lysine
  • Malonates
  • Membrane Proteins
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Mitochondrial Proteins
  • Organ Culture Techniques
  • Paraffin Embedding
  • Propionates
  • Sirtuin 3
  • Sirtuins
  • Tandem Mass Spectrometry

Keywords

  • Lens proteins
  • Malonylation
  • Mass spectrometry
  • Propionylation
  • Sirtuins

SIRT6[править]

Association between SIRT6 Methylation and Human Longevity in a Chinese Population.


Keywords

  • DNA Methylation
  • Longevity
  • Messenger RNA
  • SIRT6


The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells.


Keywords

  • DNA repair
  • MDL-800
  • SIRT6
  • aging
  • genome integrity
  • pluripotency


Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva.


Keywords

  • Alzheimer’s disease
  • aging
  • intravital diagnosis
  • saliva
  • sirtuins


Age-related epigenetic drift deregulates [i]SIRT6[/i] expression and affects its downstream genes in human peripheral blood mononuclear cells.


Keywords

  • SIRT6
  • aging
  • interaction network
  • longevity
  • methylation
  • miRNA
  • peripheral blood mononuclear cells (PBMCs)


Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators.


Keywords

  • SIRT6
  • activator
  • aging
  • cancer
  • cell metabolism
  • chromatin
  • gene expression
  • histone deacetylase (HDAC)
  • longevity
  • metabolic disorder
  • sirtuin
  • small molecule


Age-dependent role of SIRT6 in jawbone via regulating senescence and autophagy of bone marrow stromal cells.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Bone Marrow Cells
  • Humans
  • Jaw
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Knockout
  • Middle Aged
  • Osteogenesis
  • Sirtuins

Keywords

  • Autophagy
  • Bone marrow stromal cells
  • Jawbone
  • Osteoporosis
  • SIRT6
  • Senescence


Mechanism of activation for the sirtuin 6 protein deacylase.


MeSH Terms

  • Allosteric Regulation
  • Biocatalysis
  • Fatty Acids
  • HEK293 Cells
  • Histones
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Kinetics
  • Lipids
  • Mutagenesis
  • Mutation
  • NAD
  • Peptides
  • Protein Binding
  • Protein Conformation
  • Sirtuins
  • Small Molecule Libraries

Keywords

  • SIRT6
  • activator
  • cancer
  • chromatin
  • deacetylation
  • epigenetics
  • histone
  • histone deacetylase (HDAC)
  • lifespan
  • long chain acyl substrate
  • longevity
  • sirtuin


Proteomics of Long-Lived Mammals.


Keywords

  • SIRT6
  • aging
  • long-lived mammals
  • naked mole rats
  • proteomics


Sirtuins and SIRT6 in Carcinogenesis and in Diet.


MeSH Terms

  • Aging
  • Animals
  • Carcinogenesis
  • Diet
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Nanomedicine
  • Organ Specificity
  • Sirtuins

Keywords

  • SIRT6
  • cancer
  • chemotherapy
  • diet
  • modulator
  • sirtuins


SIRT6-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition.


MeSH Terms

  • Aging
  • Animals
  • Cells, Cultured
  • Disease Models, Animal
  • Endothelium, Vascular
  • Epithelial-Mesenchymal Transition
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • RNA, Long Noncoding
  • Signal Transduction
  • Sirtuins
  • Vascular Diseases

SIRT7[править]

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.


Keywords

  • LINE1
  • SIRT7
  • STING
  • aging
  • cGAS
  • stem cell

SLA[править]

Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity.


Keywords

  • Adjuvant
  • Aging
  • Influenza
  • Mouse
  • Nucleoprotein
  • Vaccination


Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography (SLA) Using Statistical Analysis.


Keywords

  • Taguchi methods
  • additive manufacturing
  • aging effect
  • analysis of variance
  • anisotropy
  • design of experiments
  • stereolithography
  • surface roughness
  • tensile testing


The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study.


Keywords 

           aged implant
         
       

           biological aging
         
       

           implant survival
         
       

           marginal bone resorption
         
       

           titanium dental implant

SLC16A7[править]

Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach.


Keywords

  • GWAS
  • KIAA0930
  • MC1R
  • SLCA45A2
  • SNP
  • Telangiectasia
  • candidate gene approach
  • epidemiology
  • genetics
  • pigmentation genes
  • red veins
  • skin aging

SLC26A2[править]

Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis.


MeSH Terms

  • Aging
  • Animals
  • Lumbar Vertebrae
  • Male
  • Mice
  • Osteogenesis
  • Phenotype
  • Spondylolysis
  • Sulfate Transporters

Keywords

  • SLC26A2
  • bone loss
  • isthmic defect
  • spondylolysis
  • vertebral development

SLC6A4[править]

The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging.


MeSH Terms

  • Aging
  • Aging, Premature
  • Animals
  • Anxiety
  • Brain-Derived Neurotrophic Factor
  • Consciousness
  • DNA Methylation
  • Depression
  • Disease Models, Animal
  • Endocrine System
  • Humans
  • Models, Genetic
  • Models, Psychological
  • Neurotransmitter Agents
  • Oxidative Stress
  • Personality
  • Psilocybin
  • Psychotropic Drugs
  • Research Design
  • Serotonin Plasma Membrane Transport Proteins
  • Stress, Psychological
  • Telomere Shortening

Keywords

  • Cellular senescence
  • Depression
  • Epigenetic clock
  • Genetic aging
  • Life extension
  • Neurophenomenology
  • Psilocybin
  • Rejuvenation
  • Rumination
  • Senotherapy
  • Telomeres

SMAD1[править]

TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Brain
  • Data Mining
  • Databases, Genetic
  • Disease Progression
  • Female
  • Gene Expression Profiling
  • Gliosis
  • Homeodomain Proteins
  • Humans
  • Ligands
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Proteomics
  • Receptors, Androgen
  • Sequence Analysis, RNA
  • Signal Transduction
  • Smad1 Protein
  • Spinal Cord
  • Transforming Growth Factor beta1
  • Up-Regulation

Keywords

  • androgen receptor
  • astrocytes
  • homeobox A5
  • multiple sclerosis
  • spinal cord
  • transforming growth factor beta 1

SMAD2[править]

Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.


MeSH Terms

  • Aging
  • Animals
  • Class I Phosphatidylinositol 3-Kinases
  • Collagen
  • Disease Models, Animal
  • Disease Progression
  • Epithelium
  • Male
  • Mice, Mutant Strains
  • Phosphorylation
  • Prostate
  • Prostatic Hyperplasia
  • Prostatic Intraepithelial Neoplasia
  • Prostatic Neoplasms
  • Signal Transduction
  • Smad2 Protein
  • Stromal Cells
  • Transforming Growth Factor beta

Keywords

  • PIK3CA
  • cancer
  • collagen
  • fibrosis
  • mouse model
  • prostate
  • stroma

SMAD3[править]

Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice.


MeSH Terms

  • Aging
  • Animals
  • Fibroblasts
  • Fibrosis
  • Gene Deletion
  • Male
  • Mice
  • Myocardium
  • Myofibroblasts
  • Signal Transduction
  • Sirtuins
  • Smad3 Protein
  • Transcriptional Activation
  • Transforming Growth Factor beta

Keywords

  • SIRT6 deacetylase
  • SMAD transcription factor
  • SMAD3
  • TGF-beta signaling
  • aging
  • aging-associated fibrosis
  • caloric restriction
  • cardiac disease
  • extracellular matrix (ECM)
  • fibrosis
  • sirtuin
  • transforming growth factor beta (TGF-beta)

SMN2[править]

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment.


MeSH Terms

  • Aging
  • Autopsy
  • Cell Survival
  • Female
  • Humans
  • Male
  • Motor Neurons
  • Muscular Atrophy, Spinal
  • Oligodeoxyribonucleotides, Antisense
  • Spinal Cord
  • Survival of Motor Neuron 2 Protein

Keywords

  • Development
  • Neurodegeneration
  • Neurodevelopment
  • Neuromuscular disease
  • Neuroscience

SMS[править]

Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly?


Keywords

  • Aging
  • Alzheimer’s disease
  • cognitive impairment
  • dementia
  • motor activity
  • music therapy
  • social interaction


Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods.


Keywords

  • Aging
  • Digital health
  • Latino
  • Physical activity
  • Text-messaging
  • mHealth

SNAP25[править]

The Biological Foundations of Sarcopenia: Established and Promising Markers.


Keywords

  • SNAP25
  • aging
  • biomarkers
  • neuromuscular junction
  • sarcopenia

SNCA[править]

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease.


MeSH Terms

  • Aging
  • Alanine
  • Amino Acid Substitution
  • Animals
  • Behavior, Animal
  • Disease Models, Animal
  • Dopaminergic Neurons
  • Humans
  • Locomotion
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mutation, Missense
  • Parkinson Disease
  • Proline
  • Threonine
  • alpha-Synuclein

SND1[править]

[Downregulation of SND1 Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP].


MeSH Terms

  • Cellular Senescence
  • Diploidy
  • Down-Regulation
  • Endonucleases
  • Fibroblasts
  • Humans
  • Nuclear Proteins

Keywords

  • Aging
  • Cellular senescent
  • SND1
  • Senescence-associated-secretory-phenotype

SOD1[править]

SOD1, more than just an antioxidant.


Keywords

  • Aging
  • Cancer
  • Neurodegenerative diseases
  • Post-translational modifications
  • Superoxide dismutase 1


The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice.


Keywords

  • 4-hydroxynonenal
  • 8-hydroxyguanosine
  • aging
  • epididymis
  • oxidative stress
  • reactive oxygen species
  • spermatozoa
  • superoxide dismutase


Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis.


MeSH Terms

  • Aging
  • Amyotrophic Lateral Sclerosis
  • Animals
  • Cardiolipins
  • Cholesterol Esters
  • Disease Models, Animal
  • Disease Progression
  • Fatty Acids, Unsaturated
  • Female
  • Humans
  • Lipid Droplets
  • Lipid Metabolism
  • Lipidomics
  • Male
  • Mass Spectrometry
  • Motor Cortex
  • Motor Neurons
  • Mutation
  • Oxidative Stress
  • Rats
  • Rats, Transgenic
  • Spinal Cord
  • Superoxide Dismutase-1

SOD2[править]

Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of SOD2 Based on a Transcriptomic Approach.


Keywords

  • aortic calcification
  • astaxanthin
  • chronic kidney disease
  • chronic kidney disease-mineral bone disorder
  • oxidative stress
  • reactive oxygen species
  • senescence
  • vascular calcification
  • vascular smooth muscle cells


Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System.


Keywords

  • Cataract
  • D-galactose
  • aging
  • alginate oligosaccharide
  • oxidative stress


Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells.


MeSH Terms

  • Antineoplastic Agents, Phytogenic
  • Autophagy
  • Biomarkers
  • Cell Cycle
  • Cell Line, Tumor
  • Cellular Senescence
  • Cyclohexanones
  • Flavones
  • Humans
  • Melanoma
  • Reactive Oxygen Species
  • Superoxide Dismutase
  • beta-Galactosidase

Keywords

  • Alkyl protoflavone
  • Flavonoid
  • Melanoma
  • Protoapigenone
  • Semi-synthesis
  • Senescence


Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-SOD2 signaling pathways in a γ-ray irradiation-induced aging mice model.


Keywords

  • SIRT1
  • SIRT3
  • aging
  • ginsenoside Rg1
  • hematopoietic progenitor cells
  • hematopoietic stem cells
  • senescence
  • γ-ray irradiation


Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast.


Keywords

  • 8-Oxo-guanine
  • aging
  • almond
  • chlorogenic acid
  • lipid peroxidation
  • mitochondria
  • oxidative stress
  • protein carbonylation
  • sirtuin
  • superoxide dismutase
  • yeast


Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish.


Keywords

  • AKT
  • aging
  • apoptosis
  • cell biology
  • p53
  • regenerative medicine
  • senescence
  • stem cells
  • telomeres
  • zebrafish


Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster.


MeSH Terms

  • Aging
  • Animal Scales
  • Animals
  • Catalase
  • Diet, High-Fat
  • Disease Models, Animal
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Fish Proteins
  • Fishes
  • Humans
  • Longevity
  • Male
  • Malondialdehyde
  • Oxidative Stress
  • Peptides
  • Superoxide Dismutase


Ellagic acid prolongs the lifespan of Drosophila melanogaster.


Keywords

  • Drosophila melanogaster
  • Ellagic acid
  • Gene expression
  • Longevity
  • Stress


Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.


MeSH Terms

  • Antioxidants
  • Catalase
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cellular Senescence
  • Chlorella vulgaris
  • DNA Damage
  • Diploidy
  • Fibroblasts
  • Gene Expression
  • Genes, p53
  • Humans
  • Male
  • Mitogen-Activated Protein Kinase 14
  • Molecular Chaperones
  • Primary Cell Culture
  • Signal Transduction
  • Superoxide Dismutase
  • Superoxide Dismutase-1

Keywords

  • Chlorella vulgaris
  • Fibroblasts
  • Replicative senescence
  • Senescence-associated genes


Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Glutathione Peroxidase
  • Male
  • Myocardium
  • Oxidation-Reduction
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase


Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.


Keywords

  • Aging
  • Curcumin
  • Hypertrophy
  • Oxidative stress
  • Yeast

SOX13[править]

In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.


MeSH Terms

  • Aging
  • Computer Simulation
  • Epistasis, Genetic
  • Humans
  • Promoter Regions, Genetic
  • Renin

Keywords

  • Aging
  • Diseases of aging
  • Gene expression
  • Gene–gene interaction
  • Genomics
  • Longevity
  • Renin-angiotensin system
  • Topologically associated domains

SOX2[править]

Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture.


Keywords

  • cell physical stimulus
  • differentiation
  • mesenchymal stem cells
  • multipotency
  • nanosecond pulsed electric fields
  • senescence


Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.


Keywords

  • Aging
  • Mesenchymal Stromal Cell (MSC) Subpopulations
  • Miniature Pig
  • Octamerbinding Transcription Factor 4 (OCT4)
  • Sex Determining Region Y-box 2 (SOX2)


Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.


MeSH Terms

  • Aging
  • Animals
  • Cell Count
  • Cell Differentiation
  • Cell Lineage
  • Hair Cells, Vestibular
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • SOXB1 Transcription Factors
  • Saccule and Utricle

Keywords

  • SOX2
  • balance disorder
  • hair cell
  • utricle
  • vestibule

SOX4[править]

Age-induced accumulation of methylmalonic acid promotes tumour progression.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Cell Line, Tumor
  • Disease Progression
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Methylmalonic Acid
  • Mice
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasms
  • SOXC Transcription Factors
  • Signal Transduction
  • Transcriptome
  • Transforming Growth Factor beta

SOX9[править]

Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice.


MeSH Terms

  • Adolescent
  • Aged
  • Aging
  • Animals
  • Arthroplasty, Replacement, Knee
  • Bone Morphogenetic Proteins
  • Cartilage, Articular
  • Cell Proliferation
  • Chondrocytes
  • Collagen Type II
  • Collagen Type X
  • Core Binding Factor Alpha 1 Subunit
  • Extracellular Matrix
  • Female
  • Growth Differentiation Factors
  • Humans
  • In Vitro Techniques
  • Knee Joint
  • Male
  • Matrix Metalloproteinase 13
  • Mice
  • Osteoarthritis, Knee
  • Parabiosis
  • Phosphorylation
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • SOX9 Transcription Factor
  • Smad2 Protein
  • Smad3 Protein
  • Stifle
  • Young Adult

SPARC[править]

SPARC Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study.


Keywords

  • aging
  • falls
  • functional mobility
  • movement smoothness
  • oldest-old


Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine (SPARC)-null mice.


MeSH Terms

  • Aging
  • Animals
  • Fibrillar Collagens
  • Gene Expression
  • Male
  • Mice
  • Mice, Knockout
  • Muscle, Skeletal
  • Myofibrils
  • Osteonectin

Keywords

  • Secreted protein acidic and rich in cysteine
  • collagen
  • fibrosis
  • myofiber
  • skeletal muscle

SPR[править]

Regulation of lifespan by neural excitation and REST.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • DNA-Binding Proteins
  • Forkhead Transcription Factors
  • Humans
  • Longevity
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Neurons
  • RNA Interference
  • RNA-Binding Proteins
  • Repressor Proteins
  • Transcription Factors

SPRTN[править]

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.


MeSH Terms

  • Acetylation
  • Aging
  • Animals
  • Cell Line
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins
  • Deubiquitinating Enzymes
  • Endopeptidases
  • Female
  • Genomic Instability
  • HEK293 Cells
  • Humans
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phosphorylation
  • Protein Domains
  • Protein Processing, Post-Translational
  • Ubiquitination

Keywords

  • DNA repair
  • DNA-protein crosslink
  • SPRTN
  • Top1cc
  • VCPIP1/VCIP135
  • acetylation
  • aging
  • genomic instability
  • metalloprotease
  • ubiquitination

SPRY1[править]

Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells.


Keywords

  • Adipogenesis
  • Adipose stem cell
  • Obesity
  • Senescence
  • Sprouty1


Mechanism of SPRY1 methylation regulating natural aging of skin epidermal cells.


Keywords

  • SPRY1
  • methylation
  • natural aging
  • skin epidermal aging

SQSTM1[править]

The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.


Keywords

  • Aging
  • C. elegans
  • Drosophila
  • SQST-1
  • SQSTM1
  • aggrephagy
  • heat shock
  • mitophagy
  • p62
  • proteostasis
  • ref(2)P
  • selective autophagy

SRC[править]

Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • CD8-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Female
  • Humans
  • Immunologic Memory
  • Influenza A virus
  • Influenza, Human
  • Male
  • Mice
  • Microscopy, Electron, Transmission
  • Mitochondria
  • T-Lymphocyte Subsets
  • Young Adult

SRD5A2[править]

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II.


Keywords

P zeylanica

  • 5α-reductase
  • dermal papilla
  • hair
  • plumbagin
  • senescence

SRF[править]

Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.


MeSH Terms

  • Aging
  • Animals
  • Diabetes Mellitus, Experimental
  • Diabetic Nephropathies
  • Gene Expression Regulation
  • Kidney
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Snail Family Transcription Factors
  • Transcription Factors

Keywords

  • Diabetic nephropathy
  • Renal fibrosis
  • SRF
  • Snail


Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.


MeSH Terms

  • Actins
  • Adaptor Proteins, Signal Transducing
  • Aging
  • Biomechanical Phenomena
  • Cells, Cultured
  • Cytoskeleton
  • Gene Expression Regulation
  • Humans
  • Hydrogels
  • Intervertebral Disc Degeneration
  • Nucleus Pulposus
  • RNA Interference
  • Trans-Activators
  • Transcription Factors
  • rho-Associated Kinases

Keywords

  • F-actin
  • SRF
  • TEAD
  • intervertebral disc
  • mechanotransduction

SRL[править]

Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Female
  • Humans
  • Income
  • Indians, South American
  • Longevity
  • Male
  • Middle Aged
  • North Carolina
  • Social Class
  • Surveys and Questionnaires
  • Survival Analysis

SRM[править]

[Geriatric specificities of localized renal cell carcinoma].


MeSH Terms

  • Age Factors
  • Aged
  • Carcinoma, Renal Cell
  • Geriatric Assessment
  • Humans
  • Kidney Neoplasms

Keywords

  • Cancer du rein
  • Diagnosis
  • Diagnostic
  • Elderly
  • Geriatrics
  • Gériatrie
  • Personne âgée
  • Petite masse rénale
  • Renal cell carcinoma
  • Small renal mass
  • Traitement
  • Treatment

SSB[править]

Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study.


MeSH Terms

  • Adolescent
  • Adolescent Nutritional Physiological Phenomena
  • Aging
  • Humans
  • Models, Biological
  • Obesity
  • Odds Ratio
  • Risk Factors
  • Sugar-Sweetened Beverages
  • Young Adult

Keywords

  • obesity
  • substitution modelling
  • sugar-sweetened beverages
  • waist circumference

SST[править]

The distance to death perceptions of older adults explain why they age in place: A theoretical examination.


Keywords

  • Agency- or belonging-related
  • Distance to death, aging in place
  • Emotions
  • Residential mobility
  • Socioemotional selectivity theory


Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool.


Keywords

  • aging
  • health services research
  • psychometrics


Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory.


Keywords

  • Aging
  • Emotion regulation
  • Future time perspective
  • Socioemotional selectivity theory
  • Time left in life

STAT1[править]

STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model.


Keywords

  • Adriamycin
  • STAT1
  • chronic nephrosis (CN)
  • mitogen-activated protein kinase
  • senescence


Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation.


MeSH Terms

  • Adipose Tissue
  • Aging
  • Animals
  • Carotid Arteries
  • Carotid Artery Diseases
  • Carotid Artery Injuries
  • Humans
  • Mice
  • Mice, Mutant Strains
  • Neointima
  • Paracrine Communication
  • STAT1 Transcription Factor

Keywords

  • aging
  • atherosclerosis
  • neointima formation
  • perivascular adipose tissue


Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation.


MeSH Terms

  • Animals
  • Bone Marrow Transplantation
  • Breast Neoplasms
  • Cell Cycle Proteins
  • Cell Line, Tumor
  • Cellular Senescence
  • Disease Models, Animal
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Integrin alphaVbeta3
  • Interleukin-1beta
  • Janus Kinase 1
  • Macrophage Activation
  • Macrophages
  • Mice
  • Mice, Knockout
  • STAT1 Transcription Factor
  • Signal Transduction

Keywords

  • Cellular senescence
  • Legumain
  • M1 polarization
  • Tumor-associated macrophage

STAT3[править]

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice.


Keywords

  • Cyclin D1
  • NF-κB
  • STAT3
  • Senescence
  • p62/SQSTM1


Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice.


Keywords

  • Aging
  • Appetite
  • Glucocorticoid
  • Leptin
  • Obesity
  • Osteoblast
  • Osteocyte


AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/STAT3 axis-mediated positive feedback loop.


Keywords

  • AMPK
  • NF-κB/STAT3 signalling
  • Oxidative stress
  • SASP
  • Senescence


Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Computational Biology
  • Gene Expression Regulation
  • Glucosamine
  • Hippocampus
  • Mice
  • Neural Stem Cells
  • Neurogenesis
  • Neuroglia
  • STAT3 Transcription Factor
  • Sequence Analysis, RNA

Keywords

  • O-GlcNAcylation
  • aging
  • gliogenesis
  • neural stem cells
  • neurogenesis


Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells.


Keywords

  • Apoptosis
  • JAK/STAT
  • caspase
  • colon cancer
  • gallotannin
  • senescence


The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.


Keywords

  • Aging
  • For review: bacterial lipolisacharide (LPS)
  • Heart
  • Inflammation
  • Interleukin-6
  • Signal transduction


Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients.


Keywords

  • IL-6
  • JAK
  • coronavirus
  • cytokine storm
  • remdesivir
  • senescence
  • stat3


Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study.


MeSH Terms

  • Aging
  • Animals
  • Caspase 3
  • Cerebellum
  • Glial Fibrillary Acidic Protein
  • Glutathione
  • Immunohistochemistry
  • Janus Kinase 1
  • Male
  • Malondialdehyde
  • Microscopy, Electron
  • Rats
  • Rats, Wistar
  • STAT3 Transcription Factor
  • Signal Transduction
  • Suppressor of Cytokine Signaling 3 Protein
  • Tumor Necrosis Factor-alpha


Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway.


Keywords

  • Cancer therapy
  • Senescence


Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells.


Keywords

  • aging biomarkers
  • cancer biology
  • cellular senescence
  • epithelial ovarian cancer
  • oxidative stress


Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice.


MeSH Terms

  • Aging
  • Animals
  • Mice
  • Mice, Inbred C57BL
  • Retina
  • Retinal Degeneration
  • STAT3 Transcription Factor
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Uveitis

Keywords

  • EAU
  • Experimental autoimmune uveitis
  • Retinal dystrophies
  • SOCS3
  • STAT3
  • Transgenic mouse
  • Uveitis


Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis.


Keywords

  • Hepatic stellate cells
  • Interleukin-10
  • Liver fibrosis
  • Senescence
  • Signal pathway

STC2[править]

Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Animals
  • Body Composition
  • Body Weight
  • Calcium-Binding Proteins
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Genome-Wide Association Study
  • Glycoproteins
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Mice
  • Middle Aged
  • Muscle Development
  • Muscle, Skeletal
  • Quantitative Trait Loci
  • Thinness

Keywords

  • UK Biobank
  • human and mouse GWAS
  • sarcopenia
  • skeletal muscle

STIM1[править]

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.


MeSH Terms

  • Animals
  • Calcium
  • Calnexin
  • Cell Nucleus
  • Disease Models, Animal
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress
  • Lamin Type A
  • Mice
  • Mice, Knockout
  • Microscopy, Electron, Transmission
  • Muscle Proteins
  • Muscle, Skeletal
  • Muscular Dystrophies
  • Mutation
  • Myoblasts
  • ORAI1 Protein
  • Progeria
  • Proteolipids
  • Stromal Interaction Molecule 1
  • Thermogenesis
  • Up-Regulation

Keywords

  • aging
  • calcium homeostasis
  • lamin A
  • muscular dystrophy
  • progeria

STS[править]

Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People.


Keywords

  • aging
  • balance
  • falls
  • fatigue
  • functional performance
  • muscle damage
  • walking


Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells.


Keywords

  • autophagy
  • caspase
  • cell death
  • remodeling
  • senescence


The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape.


Keywords

  • Chinese wild grape (Vitis quinquangularis)
  • WRKY transcription factor
  • disease resistance
  • leaf senescence
  • stilbene
  • transcriptional regulation


On the role of ageing and musculoskeletal pain on dynamic balance in manual workers.


MeSH Terms

  • Aged
  • Aging
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal
  • Musculoskeletal Pain
  • Occupational Diseases
  • Postural Balance

Keywords

  • Discomfort
  • Lower extremity function
  • Posturography
  • Sit-to-stand

SUCNR1[править]

[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging].


MeSH Terms

  • Age Factors
  • Aging
  • Animals
  • Male
  • Mitochondria
  • Neurodegenerative Diseases
  • Picolines
  • Rats
  • Receptors, G-Protein-Coupled
  • Transcription Factors

Keywords

  • Western blot analysis
  • aging
  • cerebral mitochondriogenesis
  • mexidol
  • mitochondrial dysfunction
  • rats
  • respiratory enzyme subunits
  • succinate receptor
  • transcriptional coactivator PGC-1α

SUGCT[править]

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype.


MeSH Terms

  • Aging
  • Animals
  • Anti-Bacterial Agents
  • Bacteria
  • Carnitine
  • Coenzyme A-Transferases
  • Dietary Supplements
  • Feces
  • Gastrointestinal Microbiome
  • Humans
  • Kidney
  • Lipid Metabolism
  • Liver
  • Lysine
  • Metabolic Syndrome
  • Metabolome
  • Mice
  • Mice, Knockout
  • Obesity
  • Tryptophan

Keywords

  • C7orf10
  • Glutaric aciduria type 3 (GA3)
  • Gut microflora
  • Lipids
  • Metabolomics
  • Obesity
  • Sugct

SUV39H1[править]

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice.


Keywords

  • Aging
  • H3K9me3
  • Hippocampus
  • IEGs
  • Memory
  • SUV39H1

SYK[править]

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation.


Keywords

  • TULA-2
  • aging
  • angiogenesis
  • endothelial cell
  • miR-25-3p


Identification of SYK inhibitor, R406 as a novel senolytic agent.


Keywords

  • FAK
  • apoptosis
  • cellular senescence
  • p38
  • senolytics

SYNE1[править]

Nesprin-1 impact on tumorigenic cell phenotypes.


MeSH Terms

  • Actins
  • Carcinogenesis
  • Cell Line, Tumor
  • Cell Nucleus
  • Cytoskeletal Proteins
  • Gene Expression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Microfilament Proteins
  • Nerve Tissue Proteins
  • Nuclear Envelope
  • Phenotype

Keywords

  • Cancer
  • Cellular senescence
  • Genome stability
  • Nesprin-1
  • Nuclear envelope

TAAR1[править]

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice.


MeSH Terms

  • Age Factors
  • Animals
  • Anxiety
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Mice, 129 Strain
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, G-Protein-Coupled
  • Sodium Chloride

Keywords

  • Aging
  • Anxiety
  • Hematology
  • Leukocytes
  • Neutrophils
  • TAAR1
  • Thyroid
  • Trace amines

TAS2R16[править]

Taste receptor polymorphisms and longevity: a systematic review and meta-analysis.


Keywords

  • Immune-inflammatory responses
  • Longevity
  • Meta-analysis
  • Taste receptors

TAS2R38[править]

TAS2R38 bitter taste receptor and attainment of exceptional longevity.


MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Food Preferences
  • Gene Frequency
  • Genetic Variation
  • Haplotypes
  • Humans
  • Longevity
  • Male
  • Middle Aged
  • Receptors, G-Protein-Coupled
  • Taste
  • Taste Perception
  • Young Adult

TAZ[править]

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.


Keywords

  • TAZ
  • cellular senescence
  • oncogene
  • p300
  • p53

TBC1D5[править]

TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.


Keywords

  • HPV
  • Rab7B
  • TBC1D5
  • functional genetics screen
  • proximity ligation assay
  • retrograde
  • retromer
  • senescence
  • traptamer


Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins
  • Longevity
  • Mechanistic Target of Rapamycin Complex 1
  • Membrane Microdomains
  • Signal Transduction
  • rab GTP-Binding Proteins

TBK1[править]

Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy.


Keywords

  • Aging
  • K63-linked polyubiquitination
  • Mitophagy
  • Parkin
  • TBK1

TCF7L2[править]

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.


MeSH Terms

  • Aging
  • Animals
  • Autism Spectrum Disorder
  • Cell Count
  • DNA Fingerprinting
  • Facies
  • Gene Expression Regulation
  • Humans
  • Hyperventilation
  • Intellectual Disability
  • Methyl-CpG-Binding Protein 2
  • Mice
  • Mice, Knockout
  • Myelin Sheath
  • Oligodendroglia
  • PTEN Phosphohydrolase
  • Primary Cell Culture
  • Signal Transduction
  • Transcription Factor 4
  • Transcriptome

TEC[править]

Vestibular function and cortical and sub-cortical alterations in an aging population.


Keywords

  • Aging
  • Cognition
  • Diffeomorphometry
  • Epidemiology
  • Eye-ear-nose-throat
  • MRI
  • Medical imaging
  • Shape
  • Vestibular
  • Volume


Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration.


Keywords

  • cell death
  • innate immunity
  • kidney transplantation
  • mitochondria
  • senescence
  • tubular repair


Postnatal Involution and Counter-Involution of the Thymus.


Keywords

  • Myc
  • aging
  • cyclin D1
  • growth
  • involution
  • thymus


Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.


Keywords

  • aging
  • chemotherapy
  • gender
  • luteinizing hormone-releasing hormone
  • regeneration
  • sex hormone deprivation
  • thymic epithelial cell
  • thymus


Clonogenic Culture of Mouse Thymic Epithelial Cells.


MeSH Terms

  • Aging
  • Animals
  • Cell Differentiation
  • Cell Line
  • Coculture Techniques
  • Colony-Forming Units Assay
  • DNA-Binding Proteins
  • Epithelial Cells
  • Flow Cytometry
  • Fluorescent Antibody Technique, Direct
  • Fluorescent Dyes
  • Immunomagnetic Separation
  • Mice
  • Mice, Knockout
  • Primary Cell Culture
  • Rhodamines
  • Self Tolerance
  • Staining and Labeling
  • Stem Cells
  • Thymus Gland

Keywords

  • Clonogenic assay
  • Thymic epithelial cells
  • Thymic epithelial stem cells
  • Thymus

TEF[править]

Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response.


Keywords

  • Aging
  • Cancer
  • HSP27
  • Hormesis
  • Neurodegeneratve diseases
  • Proteasome

TERT[править]

Telomeres and telomerase in risk assessment of cardiovascular diseases.


Keywords

  • Cardiovascular diseases
  • Senescence
  • Telomerase
  • Telomeres


A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit.


Keywords

  • RNA
  • RNP
  • TERT
  • TLC1
  • senescence
  • telomerase
  • telomerase RNA
  • telomere
  • two-hybrid screening
  • yeast


Angiotensin inhibition and cellular senescence in the developing rat kidney.


Keywords

  • Apoptosis
  • Cellular senescence
  • Fetal development
  • Kidney
  • Renin-angiotensin system


Decreased expression of TERT and telomeric proteins as human ovaries age may cause telomere shortening.


Keywords

  • Ovarian aging
  • TERT
  • Telomere
  • Telomere-binding proteins


The secrets of telomerase: Retrospective analysis and future prospects.


MeSH Terms

  • Aging
  • Animals
  • Diabetes Mellitus
  • Humans
  • Neoplasms
  • Telomerase
  • Telomere Shortening

Keywords

  • Cancers
  • G-quadruplex formation
  • Metabolic disorders
  • TERT gene
  • Telomere-telomerase system


Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides.


Keywords

  • Cell aging
  • Genes
  • Human mesenchymal stem cells
  • Short peptides


Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules.


Keywords

  • cellular mechanisms
  • gene expression
  • nutraceuticals
  • oxidative stress
  • senescence
  • stem cells


Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder.


MeSH Terms

  • Adult
  • Aging
  • Antimanic Agents
  • Bipolar Disorder
  • Cellular Senescence
  • Female
  • Humans
  • Lithium
  • Lithium Compounds
  • Male
  • Middle Aged
  • Mitochondria
  • Oxidative Stress
  • Polymorphism, Single Nucleotide
  • Real-Time Polymerase Chain Reaction
  • Telomerase
  • Telomere
  • Telomere Homeostasis
  • Telomere Shortening

Keywords

  • Affective disorder
  • Aging
  • Mitochondria
  • Oxidative stress
  • TERT
  • Telomere


FAM96B inhibits the senescence of dental pulp stem cells.


Keywords

  • FAM96B
  • aging
  • dental pulp stem cells (DPSCs)
  • proteomic analysis


Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges.


Keywords

  • Aging
  • Long non-coding RNA
  • Osteopontin
  • Telomeres
  • miRNA


Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells.


Keywords

  • Adipogenesis
  • Antioxidant
  • Bone marrow adiposity
  • Bone marrow skeletal stromal cells
  • Cellular senescence
  • Osteogenesis


Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines.


MeSH Terms

  • Adolescent
  • Aged
  • Anterior Cruciate Ligament
  • Cell Differentiation
  • Cell Separation
  • Cells, Cultured
  • Humans
  • Mesenchymal Stem Cells
  • Telomerase

Keywords

  • Anterior cruciate ligament
  • Immortalization
  • Mesenchymal stem cells
  • Multilineage differentiation
  • Senescence


Mitochondria, Telomeres and Telomerase Subunits.


Keywords

  • TERC
  • TERT
  • aging
  • mitochondria
  • telomerase
  • telomere


Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption.


MeSH Terms

  • Animals
  • Antioxidants
  • Behavior, Animal
  • Brain Chemistry
  • Euterpe
  • Fruit and Vegetable Juices
  • Lipid Peroxidation
  • Male
  • Mercury
  • Mice
  • Motor Skills
  • Neurotoxins
  • Plant Extracts
  • Telomere

Keywords

  • Euterpe
  • acai
  • aging
  • antioxidant
  • açaí
  • extract
  • intoxication
  • methylmercury
  • telomere


Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing.


MeSH Terms

  • Aging
  • Animals
  • Cellular Senescence
  • DNA Damage
  • DNA Replication
  • DNA, Mitochondrial
  • Epigenesis, Genetic
  • Humans
  • Mitochondria
  • Oxidative Stress
  • Stress, Physiological
  • Telomere
  • Telomere Homeostasis
  • Telomere Shortening

Keywords

  • G-quadruplex
  • R-loop
  • ageing
  • helicase
  • mitochondria
  • replication stress
  • senescence
  • telomere


Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics.


Keywords

  • Aging
  • TERT
  • associates
  • cancer
  • cell cycle
  • diseases
  • oncogenes
  • viral infection.


Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts.


MeSH Terms

  • Animals
  • Cell Cycle
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Cellular Senescence
  • Fibroblasts
  • Gene Expression
  • Gene Expression Regulation
  • Gene Knockdown Techniques
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phenotype
  • Telomerase
  • Telomere

Keywords

  • ATM
  • senescence
  • telomerase
  • tumorigenesis

TET2[править]

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease
  • Animals
  • Cognition
  • DNA-Binding Proteins
  • Female
  • Frontotemporal Dementia
  • Humans
  • Loss of Function Mutation
  • Male
  • Mice
  • Neurodegenerative Diseases
  • Proto-Oncogene Proteins

Keywords

  • AD
  • ALS
  • Alzheimer
  • FTD
  • TET2
  • aging
  • amyotrophic lateral sclerosis
  • frontotemporal dementia
  • genome sequencing
  • non-coding


60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations.


MeSH Terms

  • Adult
  • Aging
  • Biomedical Research
  • Chromosomes, Human, X
  • DNA-Binding Proteins
  • Female
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Male
  • Mutation
  • Proto-Oncogene Proteins
  • Receptors, Androgen
  • Repressor Proteins
  • X Chromosome Inactivation


DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways.


MeSH Terms

  • Animals
  • Caco-2 Cells
  • Cell Line, Tumor
  • Colonic Neoplasms
  • DNA Methylation
  • DNA-Binding Proteins
  • Down-Regulation
  • Epigenesis, Genetic
  • Female
  • Gene Regulatory Networks
  • HT29 Cells
  • Humans
  • Male
  • Mice
  • Mixed Function Oxygenases
  • Mutation
  • Neoplasms, Experimental
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins B-raf

Keywords

  • Aging
  • BRAF V600E
  • CIMP
  • Colon cancer
  • DNA methylation
  • TET


Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease.


MeSH Terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Cardiovascular Diseases
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA-Binding Proteins
  • Genetic Predisposition to Disease
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Humans
  • Inflammation
  • Middle Aged
  • Mutation
  • Phenotype
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Risk Assessment
  • Risk Factors

TF[править]

A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness.


Keywords

  • Aging
  • Beef
  • Collagen
  • Tenderness
  • Trained panel


The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize.


Keywords

  • ZmNAC
  • chlorophyll catabolic genes
  • ethylene
  • leaf senescence
  • maize


Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1).


MeSH Terms

  • Aging
  • Gene Expression Profiling
  • Gene Expression Regulation, Plant
  • Genome, Plant
  • Photosynthesis
  • Plant Leaves
  • Populus
  • Seasons
  • Transcription Factors
  • Transcriptome


Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage.


Keywords

  • Japanese quail
  • albumin
  • sperm longevity
  • sperm storage tubules
  • transferrin


OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway.


MeSH Terms

  • Abscisic Acid
  • Chlorophyll
  • Gene Expression Regulation, Plant
  • Gene Knockdown Techniques
  • Oryza
  • Plant Leaves
  • Plant Proteins
  • Transcription Factors

Keywords

  • NAC
  • OsWRKY
  • abscisic acid (ABA)
  • leaf senescence
  • rice


BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i].


MeSH Terms

  • Amino Acid Sequence
  • Brassica
  • Cellular Senescence
  • Cyclopentanes
  • Gene Expression Regulation, Plant
  • Oxylipins
  • Phenotype
  • Phylogeny
  • Plant Growth Regulators
  • Plant Leaves
  • Plant Proteins
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors

Keywords

  • Chinese flowering cabbage
  • JA
  • leaf senescence
  • transcriptional activation


Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage.


MeSH Terms

  • Aging
  • Base Sequence
  • Brassica
  • Food Preservation
  • Gene Expression Regulation, Plant
  • Gibberellins
  • Phenotype
  • Phylogeny
  • Plant Leaves
  • Plant Proteins
  • Promoter Regions, Genetic
  • Protein Binding
  • Transcription Factors

Keywords

  • Chinese flowering cabbage
  • GA
  • leaf senescence
  • transcriptional activation

TFEB[править]

A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer.


Keywords

  • Senescence
  • autophagy
  • glycolysis
  • hypoxia
  • lipofuscin
  • lung cancer


ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia.


Keywords

  • embryonic stem cells derived small extracellular vesicles (ESC‐sEVs)
  • hippocampal neural stem cells (HNSCs)
  • lysosomes
  • senescence
  • vascular dementia


Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Cells, Cultured
  • Homocysteine
  • Humans
  • Hyperhomocysteinemia
  • Kidney
  • Kidney Diseases
  • Male
  • Metalloporphyrins
  • Peroxynitrous Acid
  • Rats
  • Rats, Sprague-Dawley


Polyamines reverse immune senescence via the translational control of autophagy.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Humans
  • Lysosomes
  • Polyamines
  • Protein Processing, Post-Translational
  • Spermidine

Keywords

  • Aging
  • B cells
  • EIF5A
  • TFEB
  • autophagy
  • hypusine
  • spermidine
  • translation


Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.


MeSH Terms

  • Adaptive Immunity
  • Age Factors
  • Aging
  • Animals
  • Autophagy
  • B-Lymphocytes
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Cellular Senescence
  • HEK293 Cells
  • Humans
  • Immunologic Memory
  • Immunosenescence
  • Jurkat Cells
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • NIH 3T3 Cells
  • Peptide Initiation Factors
  • Protein Processing, Post-Translational
  • RNA-Binding Proteins
  • Signal Transduction
  • Spermidine

Keywords

  • B cell
  • TFEB
  • aging
  • autophagy
  • eIF5A
  • spermidine

TFPI[править]

Identification of cardiovascular health gene variants related to longevity in a Chinese population.


Keywords

  • Chinese
  • factor related to cardiovascular health (FCH)
  • genetic variation
  • lipid metabolism
  • longevity

TG[править]

Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae.


Keywords

  • Budding yeast
  • Rad52
  • Replicative senescence
  • Subtelomeric Y’ elements
  • Telomerase-independent telomere maintenance
  • Telomere recombination


E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease.


Keywords

  • Aging
  • CKD
  • Diabetes
  • Diet
  • E4orf1
  • FA synthesis
  • Hyperinsulinemia
  • Insulin
  • Lipid metabolism
  • Obesity


Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.


Keywords

  • Aging
  • Cardiometabolic
  • Lipemia
  • Metabolism
  • Nutrition


Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation.


Keywords

  • PPARα
  • RAGE
  • aging
  • hepatic steatosis
  • mitochondria


Fenofibrate impairs liver function and structure more pronounced in old than young rats.


Keywords

  • Aging
  • Fenofibrate
  • Lipids
  • Liver function and morphology
  • Rat
  • serum


Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study.


MeSH Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Blood Glucose
  • Blood Pressure
  • Cardiovascular Diseases
  • Cholesterol
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • Humans
  • Hypercholesterolemia
  • Hypertension
  • Hypertriglyceridemia
  • Italy
  • Male
  • Middle Aged
  • Risk Assessment
  • Risk Factors
  • Triglycerides
  • Vascular Stiffness
  • Young Adult

Keywords

  • Arterial aging
  • Awareness
  • Epidemiology
  • Pulse wave velocity
  • Risk factors


Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.


MeSH Terms

  • Aging
  • Animals
  • Daphnia
  • Diglycerides
  • Female
  • Lipid Metabolism
  • Longevity
  • Male
  • Phosphatidylcholines
  • Sphingomyelins
  • Triglycerides


Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products.


MeSH Terms

  • Benzopyrans
  • Charcoal
  • Humic Substances
  • Microbiota
  • Soil Microbiology
  • Solubility
  • Triticum
  • Water

Keywords

  • Biochar
  • Biotic incubation aging
  • Dissolved organic matter (DOM)
  • Excitation-emission matrix
  • Humification


Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants.


MeSH Terms

  • Animals
  • Caenorhabditis elegans
  • Hazardous Substances
  • Humans
  • Longevity
  • Reproduction
  • Toxicity Tests

TH[править]

Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study.


Keywords

  • Aging
  • Muscle mass
  • Muscle strength
  • Oldest-old
  • Physical performance
  • Rehabilitation
  • Thyroid hormone signaling


Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.


Keywords

  • Behavioral responses
  • Immunosenescence
  • Oxidative-inflammatory stress
  • Social environmental strategy
  • Tyrosine hydroxylase haploinsufficient mice


Mechanism of thyroid hormone signaling in skeletal muscle of aging mice.


Keywords

  • Aging
  • Mice
  • Skeletal muscle
  • Thyroid hormone signaling


Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study.


MeSH Terms

  • Absorptiometry, Photon
  • Adult
  • Bone Density
  • Cancellous Bone
  • Cohort Studies
  • Female
  • Humans
  • Lumbar Vertebrae
  • Male
  • Prospective Studies
  • Republic of Korea

Keywords

  • Aging
  • Bone mineral density
  • Natural history
  • Osteoporosis


Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease.


Keywords

  • RRID:AB_11145309
  • RRID:AB_2109791
  • RRID:AB_228307
  • RRID:AB_228341
  • RRID:AB_2336820
  • RRID:AB_2631098
  • RRID:AB_390204
  • RRID:MGI:5651135
  • RRID:SCR_001881
  • RRID:SCR_002798
  • RRID:SCR_003070
  • RRID:SCR_004946
  • RRID:SCR_005223
  • aging
  • dopaminergic neuron
  • glial fibrillary acidic protein
  • proteome
  • proteomics
  • substantia nigra


Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Corpus Striatum
  • Dopaminergic Neurons
  • Male
  • Motor Activity
  • Neuroprotective Agents
  • Rats
  • Rats, Wistar
  • Substantia Nigra
  • Tyrosine 3-Monooxygenase
  • Withanolides

Keywords

  • Ageing
  • Dopamine
  • Striatum
  • Substantia nigra
  • Withaferin-A


Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011.


MeSH Terms

  • Absorptiometry, Photon
  • Aged
  • Bone Density
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Femur Neck
  • Humans
  • Lumbar Vertebrae
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Osteoporosis
  • Republic of Korea
  • Surveys and Questionnaires

Keywords

  • Aging
  • Bone mineral density
  • Exercise
  • Gender
  • Osteoporosis
  • Physical activity


Age-Related Resistance to Thyroid Hormone Action.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Animals
  • Humans
  • Hyperthyroidism
  • Hypothyroidism
  • Iodide Peroxidase
  • Male
  • Receptors, Thyroid Hormone
  • Thyroid Hormones
  • Thyroxine
  • Triiodothyronine


Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish.


MeSH Terms

  • Aging
  • Animals
  • Animals, Genetically Modified
  • Glucose
  • Glucose Transport Proteins, Facilitative
  • Homeostasis
  • Hyperglycemia
  • Iodide Peroxidase
  • Islets of Langerhans
  • Male
  • Proglucagon
  • Proinsulin
  • Receptor, Insulin
  • Receptors, Glucagon
  • Zebrafish


Age effect on thyroid hormone brain response in male mice.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Gene Expression
  • Hyperthyroidism
  • Hypothyroidism
  • Male
  • Maze Learning
  • Mice, Inbred C57BL
  • Monocarboxylic Acid Transporters
  • Organic Cation Transport Proteins
  • Rotarod Performance Test
  • Symporters
  • Thyroid Hormones
  • Thyrotropin
  • Thyrotropin-Releasing Hormone

Keywords

  • Ageing
  • Hyperthyroidism
  • Hypothyroidism
  • Male mice
  • Thyroid hormones


Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine.


MeSH Terms

  • Aging
  • Animals
  • DNA-Binding Proteins
  • Hypothalamo-Hypophyseal System
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Myocardium
  • Pituitary Gland
  • Thyroid Gland
  • Thyroid Hormones
  • Thyrotropin
  • Thyroxine
  • Transcription Factors

Keywords

  • HPT-axis
  • aging
  • mice
  • thyroid gland
  • thyroid hormones

TLR1[править]

Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.


Keywords

  • TLR
  • aging
  • innate immunity
  • lifelong exercise
  • skeletal muscle


Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.


MeSH Terms

  • Age Factors
  • Animals
  • Breeding
  • Cattle
  • Czech Republic
  • Female
  • Genotype
  • Longevity
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Reproduction
  • Toll-Like Receptor 1
  • Toll-Like Receptor 2
  • Toll-Like Receptor 6
  • Toll-Like Receptors

Keywords

  • Cattle
  • Diversity
  • Effect prediction
  • Health traits
  • Toll-like receptors

TLR2[править]

Changes in salivary microbial sensing proteins CD14 and TLR2 with aging.


MeSH Terms

  • Adolescent
  • Adult
  • Aging
  • Biomarkers
  • Child
  • Child, Preschool
  • Humans
  • Lipopolysaccharide Receptors
  • Middle Aged
  • Saliva
  • Salivary Proteins and Peptides
  • Toll-Like Receptor 2
  • Young Adult

Keywords

  • Age changes
  • CD14
  • Saliva
  • Toll-like receptor-2


Culture Model for Non-human Primate Choroid Plexus.


Keywords

  • aging
  • cell culture
  • choroid plexus
  • epithelial cell
  • infectious disease
  • rhesus macaque

TLR4[править]

Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.


Keywords

  • adipokines
  • aging
  • batokines
  • biglycan
  • cytokines
  • fat explant cultures
  • high mobility group box-1 protein
  • lipopolysaccharide


Role of Toll Like Receptor 4 in Alzheimer's Disease.


Keywords

  • Alzheimer’s disease
  • TLR4
  • aging
  • amyloid beta oligomers
  • calcium
  • hippocampal neurons


Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.


Keywords

  • aging
  • dissertations
  • theses


Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.


Keywords

  • aging
  • desialylation
  • galectin-3
  • microglia
  • neurodegeneration
  • phagocytosis
  • sialic acid


Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway.


Keywords

  • chemerin
  • inflammation
  • intervertebral disc
  • nucleus pulposus
  • senescence


Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.


Keywords

  • TLR4
  • adult hippocampal neurogenesis
  • aging
  • proliferation
  • sex differences


Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.


MeSH Terms

  • Animals
  • B-Lymphocytes
  • Cells, Cultured
  • Immunity, Cellular
  • Immunosenescence
  • Male
  • Malondialdehyde
  • Oxidative Stress
  • Rats
  • Rats, Wistar
  • Spleen
  • Superoxide Dismutase
  • T-Lymphocytes

Keywords

  • Aging
  • Immunohistochemistry
  • Immunosenescence
  • Oxidative stress
  • Spleen


Leptin induces immunosenescence in human B cells.


MeSH Terms

  • Adult
  • Aged
  • B-Lymphocytes
  • Humans
  • Immunoglobulin Class Switching
  • Immunosenescence
  • Leptin
  • Middle Aged
  • Obesity

Keywords

  • B cells
  • Immunosenescence
  • Leptin
  • Obesity


Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.


Keywords

  • DTaP
  • IgG subclass
  • antibody longevity
  • antibody magnitude
  • genetics
  • vaccine


Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway.


MeSH Terms

  • Aging
  • Animals
  • Autophagic Cell Death
  • Cognitive Dysfunction
  • Male
  • Myeloid Differentiation Factor 88
  • NF-kappa B
  • Rats
  • Rats, Sprague-Dawley
  • Sevoflurane
  • Signal Transduction
  • Sirolimus
  • Toll-Like Receptor 4

TLR9[править]

Age-Associated B Cells.


Keywords

  • B lymphocytes
  • aging
  • autoimmunity
  • memory B cells

TMEM106B[править]

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Apolipoproteins E
  • Brain
  • Cohort Studies
  • DNA-Binding Proteins
  • Female
  • Gene Expression Regulation
  • Haplotypes
  • Humans
  • Lysosomes
  • Male
  • Membrane Proteins
  • Myelin Sheath
  • Nerve Tissue Proteins
  • Progranulins
  • Quantitative Trait Loci
  • RNA Splicing Factors
  • TDP-43 Proteinopathies

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • GRN
  • RBFOX1
  • TDP-43
  • TMEM106B
  • co-expression module
  • cognitive resilience
  • eQTL
  • expression quantitative trait loci
  • sQTL
  • splicing quantitative trait loci

TMPRSS2[править]

Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.


Keywords

  • SARS-CoV-2
  • dysfunction
  • exposome
  • immunosenescence
  • metabolomics
  • mitochondria
  • pollutant
  • socioeconomic
  • stress


Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.


MeSH Terms

  • Age Factors
  • Angiotensin-Converting Enzyme 2
  • Animals
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections
  • Gene Expression
  • Gene Expression Profiling
  • Immunohistochemistry
  • In Situ Hybridization
  • Mice
  • Olfaction Disorders
  • Olfactory Mucosa
  • Olfactory Receptor Neurons
  • Pandemics
  • Peptidyl-Dipeptidase A
  • Pneumonia, Viral
  • RNA-Seq
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2
  • Serine Endopeptidases
  • Virus Internalization

Keywords

  • ACE2 expression
  • COVID-19
  • SARS-CoV-2
  • aging
  • anosmia
  • olfactory epithelium

TNC[править]

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging.


Keywords

  • TGF-β
  • aging
  • collagen
  • extracellular matrix
  • fibroblast
  • skin
  • tenascin C


Tenascin-C expression controls the maturation of articular cartilage in mice.


MeSH Terms

  • Aging
  • Animals
  • Cartilage, Articular
  • Cell Count
  • Genotype
  • Mice
  • Tenascin

Keywords

  • Adhesion
  • Articular cartilage
  • Cartilage defect
  • Cell density
  • Knock-out mouse
  • Load
  • Tenascin C


Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers.


Keywords

  • Aging
  • Mechanical properties
  • Nano-zirconia
  • Phase transformation
  • Resin nano-ceramic
  • Resin-based composite

TNF[править]

Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.


Keywords

  • AML-12 cells
  • Aging
  • ApoE(−/−) mice
  • Naringenin
  • Nonalcoholic steatohepatitis
  • SIRT1


Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.


Keywords

  • Aging
  • Ferroptosis
  • Heme oxygenase-1
  • Iron metabolism
  • Microglia
  • Neuroinflammation


Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.


Keywords

  • Autophagy
  • D-galacose
  • Ionizing radiation
  • Senescence
  • β-hydroxybutyric acid


Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and TNF-α in regulating cancer pathogenesis.


Keywords

  • Apoptosis
  • Autophagy
  • EMT
  • Fibrogenesis
  • Senescence
  • TGF-β and TNF-α


Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.


Keywords

  • Cellular senescence
  • Oxidative stress
  • SASP
  • SNHG29
  • Spontaneous preterm birth
  • p53/p21


Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.


Keywords

  • chemokines
  • cognition
  • cytokines
  • healthy aging
  • immune molecules


Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.


Keywords

  • Ribes meyeri anthocyanin
  • aging
  • cognition
  • naringenin
  • senescence


Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.


Keywords

  • Aging
  • Inflammation
  • Physical exercise


Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.


Keywords

  • Aging
  • Bone loss
  • Osteoclastogenesis
  • Periodontitis
  • Porphyromonas gingivalis lipopolysaccharide


New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.


Keywords

  • 3′
  • 5′-cyclic diguanylic acid (cyclic di-GMP)
  • aging
  • monocyte-derived dendritic cells (moDCs)
  • tumor necrosis factor (TNF)
  • vaccine


Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.


Keywords

  • Aging
  • Biologics
  • Cognition
  • Rheumatic diseases


Cotinine ameliorates memory and learning impairment in senescent mice.


Keywords

  • Aging
  • Cognitive impairment
  • Cotinine
  • Improvement
  • α(7)nAChRs


Kynurenines link chronic inflammation to functional decline and physical frailty.


Keywords

  • Aging
  • Cytokines
  • Inflammation
  • Neurodegeneration


Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Heart
  • In Situ Nick-End Labeling
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart
  • Muscle, Skeletal
  • Physical Conditioning, Animal
  • Running
  • Sedentary Behavior

Keywords

  • Caspase-independent
  • Cell death
  • Fas dependent
  • IGF-related
  • Mitochondrial


Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.


Keywords

  • aging
  • bioactive
  • functional ingredient
  • immobilization
  • inflammation
  • muscle atrophy
  • peptide
  • protein synthesis
  • skeletal muscle


Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.


Keywords

  • adverse late effects
  • childhood
  • immune recovery
  • immunosenescence
  • neuroblastoma


FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.


Keywords

  • Endothelial cells
  • Fk506
  • Hyaluronan
  • LYVE-1
  • Lung lymphatic
  • Senescence
  • TERT


Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.


Keywords

  • aging
  • androgen
  • heart failure
  • myocardial infarction
  • testosterone
  • thromboembolism


Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.


Keywords

  • Aging
  • Alzheimer's disease
  • Inflammation
  • Microglia
  • Proteomics
  • Senescence


Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.


Keywords

  • Aging
  • Alternate day fasting (ADF)
  • Intermittent fasting (IF)
  • Oxidative stress
  • Time-Restricted feeding (TRF)


Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.


Keywords

  • HIV
  • aging
  • anti-retroviral therapy
  • inflammation
  • morbidity


Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.


Keywords

  • Aging
  • chrysin
  • inflammation
  • liver
  • oxidative stress
  • rat.


Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.


Keywords

  • Aging
  • Ghrelin
  • Immunosuppression
  • Sepsis
  • Vagus nerve


Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.


Keywords

  • Aging
  • Delirium
  • Genome-wide DNA methylation
  • Immune response
  • Inflammatory response


[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.


Keywords

  • Andrographis paniculata
  • andrographolide
  • inflammation
  • keratinocytes
  • oxidative stress
  • skin aging


Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.


Keywords

  • Aging
  • Etanercept
  • Inflammation
  • Learning
  • Memory
  • TNFα
  • Vascular dementia


Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.


Keywords

  • NAFLD
  • aging
  • bacterial translocation
  • cytokines
  • insulin resistance


Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.


Keywords

  • BMSCs
  • P21/PCNA
  • aging
  • immune system
  • oxidative stress


Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants.


Keywords

  • cosmetics
  • glycolic acid
  • keratolytic agents
  • rejuvenation
  • skin aging


A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.


Keywords

  • A20
  • Nuclear factor-kappa B
  • Nucleus pulposus
  • Senescence
  • Tumour necrosis factor alpha


Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.


MeSH Terms

  • Adult
  • Aging
  • Estradiol
  • Female
  • Humans
  • Hydrocortisone
  • Immunity, Cellular
  • Intracellular Fluid
  • Male
  • Middle Aged
  • Signal Transduction
  • Testosterone
  • Young Adult

Keywords

  • 17β-estradiol
  • Cortisol
  • Cytokines
  • Testosterone
  • Tyrosine hydroxylase


Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.


Keywords

  • Aging
  • Complement system
  • Elderly
  • Immune
  • Inflammation
  • Lectin


Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.


Keywords

  • Aging
  • FoxO1
  • Male osteoporosois
  • OPG
  • RANKL
  • Resveratrol
  • SIRT1
  • Type II osteoporosis


The senescence-associated secretome as an indicator of age and medical risk.


Keywords

  • Aging
  • Cellular senescence


Exercise Partially Rejuvenates Muscle Stem Cells.


Keywords

  • TGF-beta
  • aging
  • cyclin D1
  • longevity
  • regeneration
  • stem cells


Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.


MeSH Terms

  • Age Factors
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Cyclooxygenase 2
  • Diet, High-Fat
  • Dose-Response Relationship, Drug
  • Fruit
  • Interleukin-1beta
  • Interleukin-6
  • Lipid Peroxidation
  • Male
  • Mice
  • Myrtaceae
  • Oxidative Stress
  • Plant Extracts
  • Prostatitis
  • T-Lymphocytes

Keywords

  • aging
  • bioactive compounds
  • obesity
  • overweight
  • polyphenols


Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.


Keywords

  • Aging
  • Diabetes mellitus
  • Endothelial cells
  • Hypertension
  • Mesenchymal stem cells


[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].


MeSH Terms

  • Aging
  • Animals
  • Cognition
  • Cognition Disorders
  • Fear
  • Hippocampus
  • Mice
  • Mice, Inbred ICR

Keywords

  • Central nervous system
  • Cognition disorders
  • Inflammation
  • Postoperative period
  • Sleep deprivation


Can blocking inflammation enhance immunity during aging?


Keywords

  • Inflammaging
  • p38-MAP Kinase
  • senescence
  • senolytics


[FAS- and TNF-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Female
  • Hypothalamus
  • Mice
  • Mice, Transgenic
  • Signal Transduction
  • Tumor Necrosis Factor-alpha
  • fas Receptor

Keywords

  • FAS-, TNF-dependent pathways
  • aging
  • apoptosis
  • hypothalamus
  • neurons


Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Analgesia, Patient-Controlled
  • Delirium
  • Esophagectomy
  • Female
  • Geriatrics
  • Humans
  • Male
  • Middle Aged
  • Nerve Block
  • Postoperative Complications
  • Prospective Studies
  • Ultrasonography


17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.


MeSH Terms

  • Aging
  • Animals
  • Anti-Inflammatory Agents
  • Blood Glucose
  • Cytokines
  • Estradiol
  • Female
  • Heart
  • Insulin
  • Insulin Resistance
  • Lipid Metabolism
  • Menopause
  • Ovariectomy
  • Rats
  • Rats, Wistar
  • Signal Transduction

Keywords

  • 17β-estradiol
  • Aging
  • Cytokines
  • Heart
  • Insulin signalling


Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.


MeSH Terms

  • Adenocarcinoma
  • Aging
  • Animals
  • Cell Line, Tumor
  • Glycols
  • Humans
  • Mice
  • Nanoparticles
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Selenium Compounds


Pinitol suppresses TNF-α-induced chondrocyte senescence.


Keywords

  • Cellular senescence
  • Nrf2
  • Osteoarthritis
  • Pinitol
  • TNF-α


[Aging of skin fibroblasts: genetic and epigenetic factors.]


MeSH Terms

  • Cells, Cultured
  • Epigenesis, Genetic
  • Fibroblasts
  • Humans
  • Skin Aging

Keywords

  • aging
  • melatonin
  • signal molecules
  • skin fibroblasts


Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.


Keywords

  • Aging
  • Cytokines.
  • Dynapenia
  • Inflamm-aging


Associations of TNF-α -308 G>A and TNF-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Humans
  • Longevity
  • Male
  • Natriuretic Peptide, Brain
  • Tumor Necrosis Factor-alpha

Keywords

  • Physical function
  • TNF-α -308 G>A polymorphism
  • TNF-β 252 A>G polymorphism
  • plasma BNP
  • population study.


3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.


Keywords

  • 3D TECA
  • Cellular senescence
  • Fibroblast migration
  • SA-β-gal
  • TNF-α


Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.


MeSH Terms

  • Animals
  • Antioxidants
  • Apoptosis
  • Cytokines
  • Immunologic Factors
  • Immunosenescence
  • Male
  • Medicine, Chinese Traditional
  • Mice
  • Models, Animal
  • NF-E2-Related Factor 2
  • Oxidative Stress
  • Phytochemicals
  • Schisandra
  • Spleen

Keywords

  • Anwulignan
  • anti-apoptosis
  • antioxidation
  • immunosenescence


Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.


Keywords

  • Aging
  • Immunosuppression
  • Side Effect
  • Thiopurine


The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.


MeSH Terms

  • Aging
  • Animals
  • Antioxidants
  • Cell Line
  • Cellular Senescence
  • Citrus
  • Cytoprotection
  • Disease Models, Animal
  • Flavanones
  • Humans
  • Interleukin-6
  • Mice
  • Myocardium
  • Protein Binding
  • Rats
  • Reactive Oxygen Species
  • Sirtuin 1
  • Tumor Necrosis Factor-alpha


In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.


Keywords

  • IL-12
  • IL-18
  • TCR bypass stimulation
  • senescence
  • γδ T cells


Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.


Keywords

  • Aging
  • Cytokines
  • ERα
  • Estrogen
  • Leptin sensitivity


Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Cytokines
  • Humans
  • Inflammation Mediators
  • Mitochondria
  • Neurofibrillary Tangles
  • Neurons
  • Neuroprotective Agents
  • Thioctic Acid


Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.


MeSH Terms

  • Aging
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Astrocytes
  • Carbamates
  • Cell Line, Tumor
  • Cell Survival
  • Diosgenin
  • Dose-Response Relationship, Drug
  • Drug Design
  • Galactose
  • Humans
  • Inflammation
  • Male
  • Mice
  • Mice, Inbred ICR
  • Molecular Structure
  • Neuroprotective Agents
  • Oxidative Stress
  • Protein Aggregates
  • Structure-Activity Relationship

Keywords

  • Alzheimer’s disease
  • Anti-Aβ activity
  • Anti-inflammatory
  • Antioxidant
  • Diosgenin
  • Multi-target-directed ligands


Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.


MeSH Terms

  • Aging
  • Animal Feed
  • Animals
  • Brain-Derived Neurotrophic Factor
  • Cognitive Dysfunction
  • Diet
  • Gastrointestinal Microbiome
  • Gene Expression Regulation
  • Hippocampus
  • Male
  • Mice
  • Soybeans
  • Tumor Necrosis Factor-alpha

Keywords

  • BDNF
  • SAMP8
  • cognitive impairment
  • neuroprotection
  • okara


Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.


MeSH Terms

  • Aging
  • Anesthesia, General
  • Animals
  • Behavior, Animal
  • Hippocampus
  • Inflammation
  • Male
  • Maze Learning
  • NF-kappa B
  • Postoperative Cognitive Complications
  • Rats
  • Rats, Sprague-Dawley
  • Splenectomy
  • Tumor Necrosis Factor-alpha
  • Vagus Nerve Stimulation

Keywords

  • Cognitive dysfunction
  • General anesthesia
  • Inflammation
  • Vagus nerve stimulation


Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.


MeSH Terms

  • Animals
  • Annulus Fibrosus
  • Anti-Inflammatory Agents
  • Cellular Senescence
  • HMGB1 Protein
  • Inflammation
  • Intervertebral Disc Degeneration
  • Lipopolysaccharides
  • Metformin
  • Rabbits
  • Stem Cells

Keywords

  • HMGB1
  • annulus fibrosis stem cells
  • cell senescence
  • intervertebral disc degeneration
  • metformin


The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Blueberry Plants
  • Double-Blind Method
  • Female
  • Fragaria
  • Fruit
  • Humans
  • Male
  • Microglia
  • Middle Aged
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Oxidative Stress
  • Postprandial Period
  • Rats
  • Tumor Necrosis Factor-alpha


Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.


Keywords

  • Aging
  • Arsenic
  • Articular cartilage
  • Human chondrocyte
  • Senescence
  • Senescence-associated secretory phenotype


Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.


MeSH Terms

  • Age Factors
  • Animals
  • Bone Density
  • Bone Density Conservation Agents
  • Bone Marrow Cells
  • Bone Remodeling
  • Bone and Bones
  • Cells, Cultured
  • Cytokines
  • Dietary Supplements
  • Disease Models, Animal
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
  • Female
  • JNK Mitogen-Activated Protein Kinases
  • Mice, Inbred C57BL
  • Osteoporosis
  • Signal Transduction
  • p38 Mitogen-Activated Protein Kinases

Keywords

  • aging
  • bone mineral density
  • bone resorption
  • concentrated fish oil
  • cytokines
  • inflammation
  • omega-3 fatty acids


Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.


MeSH Terms

  • Aging
  • Animals
  • Chronic Disease
  • Cytokines
  • Disease Models, Animal
  • Epithelium
  • Flow Cytometry
  • Immunity, Innate
  • Inflammation
  • Macaca mulatta
  • NK Cell Lectin-Like Receptor Subfamily B
  • Phenotype
  • Th17 Cells

Keywords

  • CD161+ cells
  • I-FABP
  • Inflammaging
  • LBP
  • Leaky gut
  • sCD14


Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.


MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Case-Control Studies
  • Cell Differentiation
  • Cells, Cultured
  • Clonal Evolution
  • Gene Expression Profiling
  • Humans
  • Interferon-gamma
  • Leukocytes, Mononuclear
  • Middle Aged
  • Single-Cell Analysis
  • Tumor Necrosis Factor-alpha

Keywords

  • CD4 CTL
  • aging
  • centenarian
  • single-cell transcriptome


Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.


MeSH Terms

  • Aging
  • Animals
  • Bacteria
  • Biomarkers
  • Drugs, Chinese Herbal
  • Gastrointestinal Microbiome
  • Hyperlipidemias
  • Lipid Metabolism
  • Male
  • Metabolome
  • Metabolomics
  • Mice
  • Mice, Inbred C57BL

Keywords

  • Aging
  • FTZ
  • Gut microbiota
  • Metabolomics


Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.


MeSH Terms

  • Aging
  • Animals
  • Apoptosis
  • Cytokines
  • Estrogens
  • Female
  • Humans
  • Inflammation
  • Intervertebral Disc
  • Intervertebral Disc Degeneration
  • Intervertebral Disc Displacement
  • Male
  • Phosphatidylinositol 3-Kinases
  • Signal Transduction

Keywords

  • Ageing
  • Apoptosis
  • Intervertebral disc degeneration
  • Oestrogen
  • Spine


MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.


MeSH Terms

  • Aging
  • Animals
  • Caloric Restriction
  • Cytokines
  • Diet Therapy
  • Inflammation
  • Interleukin-1beta
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • MicroRNAs
  • Models, Animal
  • RAW 264.7 Cells
  • Transcriptional Activation
  • Tumor Necrosis Factor-alpha
  • Up-Regulation

Keywords

  • Caloric restriction
  • Cellular immunology
  • Cytokines
  • Macrophages
  • microRNA


Aerobic exercise modulates cytokine profile and sleep quality in elderly.


MeSH Terms

  • Aged
  • Cytokines
  • Exercise
  • Female
  • Humans
  • Male
  • Middle Aged
  • Sedentary Behavior
  • Sleep Wake Disorders

Keywords

  • Sleep quality
  • aerobic exercise
  • aging
  • inflammatory cytokines


Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.


MeSH Terms

  • Aging
  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Galactose
  • Male
  • Memory Disorders
  • Mice
  • Mice, Inbred ICR
  • NF-E2-Related Factor 2
  • Signal Transduction
  • Trehalose

Keywords

  • Antioxidant stress
  • Cognitive impairment
  • Inflammation
  • Nrf2
  • Trehalose
  • d-galactose


Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].


MeSH Terms

  • Aging
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Biological Products
  • Chlorella
  • Cytokines
  • Disease Models, Animal
  • Galactose
  • Inflammation
  • Interleukin-6
  • Lipopolysaccharides
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B
  • Nitric Oxide
  • Oxidative Stress
  • RAW 264.7 Cells
  • Superoxide Dismutase
  • Tumor Necrosis Factor-alpha

Keywords

  • Chlorella pyrenoidosa
  • NF-κB
  • PPARs
  • anti-aging
  • anti-inflammation
  • pigment–protein complex


Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.


Keywords

  • Aging
  • BACE
  • Cytokines
  • Disability
  • Fall risk
  • Low back pain


Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.


Keywords

  • Acetylcholinesterase inhibitor
  • Aging
  • CHRFAM7A
  • CHRNA7
  • Cholinergic anti-inflammatory pathway
  • Neuroinflammation


Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.


Keywords

  • Fufang Zhenzhu Tiaozhi
  • liver aging
  • mass spectrometry
  • metabolomics
  • ultra-performance liquid chromatography


Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.


Keywords

  • Brain aging
  • Cognition
  • Gray matter volume
  • Inflammation
  • Neuroimaging


Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.


MeSH Terms

  • Adipose Tissue
  • Adult
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Cellular Senescence
  • Dasatinib
  • Female
  • Humans
  • Mesenchymal Stem Cells
  • Pre-Eclampsia
  • Pregnancy
  • Protein Kinase Inhibitors

Keywords

  • Angiogenesis, Senolytics, Dasatinib
  • Mesenchymal stem cells
  • Preeclampsia
  • Senescence


Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.


MeSH Terms

  • Aging
  • Animals
  • Bifidobacterium longum
  • Cognitive Dysfunction
  • Dysbiosis
  • Feces
  • Gastrointestinal Microbiome
  • Humans
  • Lipopolysaccharides
  • Mice
  • Mice, Transgenic
  • Probiotics


Moderate hyperoxia induces senescence in developing human lung fibroblasts.


MeSH Terms

  • Autophagy
  • CCAAT-Enhancer-Binding Protein-beta
  • Cell Proliferation
  • Cellular Senescence
  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Damage
  • Endoplasmic Reticulum Stress
  • Etoposide
  • Extracellular Matrix
  • Fetus
  • Fibroblasts
  • G2 Phase Cell Cycle Checkpoints
  • Gene Expression Regulation
  • Humans
  • Hyperoxia
  • Interleukin-1
  • Interleukin-8
  • Lung
  • Matrix Metalloproteinase 3
  • Oxygen
  • Plasminogen Activator Inhibitor 1
  • Primary Cell Culture
  • Tumor Necrosis Factor-alpha
  • Tumor Suppressor Protein p53

Keywords

  • autophagy
  • endoplasmic reticulum stress
  • lung development
  • oxygen
  • senescence


Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.


MeSH Terms

  • Aged
  • Aging
  • Animals
  • Antigens, CD
  • Cell Adhesion Molecules
  • Cells, Cultured
  • Endothelium, Vascular
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Middle Aged
  • Signal Transduction

Keywords

  • aging
  • anti-aging
  • cytokines
  • inflammation
  • mouse
  • reactive oxygen species


Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice.


Keywords

  • aging
  • cerebral amyloidosis
  • insulin-like growth factor
  • neurogenesis
  • neuroinflammation
  • tumor necrosis factor


Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.


MeSH Terms

  • Aging
  • Animals
  • Chlorpyrifos
  • Diet, High-Fat
  • Gastrointestinal Microbiome
  • Hypothalamo-Hypophyseal System
  • Inflammation
  • Male
  • Pituitary-Adrenal System
  • RNA, Ribosomal, 16S
  • Rats

Keywords

  • 16S rRNA gene sequencing
  • Gut endocrine
  • Gut-brain axis
  • Hormone
  • Hypothalamic-pituitary-adrenal axis
  • Inflammation

TOMM20[править]

Effect of aging on mitochondria and metabolism of bovine granulosa cells.


Keywords

  • Aging
  • Cow
  • Granulosa cells
  • Mitochondria

TP53[править]

p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.


Keywords

  • Cellular senescence
  • Dental follicle cells
  • E2F-1
  • Osteogenic differentiation
  • p53


Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.


MeSH Terms

  • Age Factors
  • Aged
  • Aging
  • Anemia
  • Female
  • Hematopoiesis
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Mutation
  • Prospective Studies


TP53/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.


Keywords

  • Aging
  • PDAC
  • SERPINE1
  • TP53
  • cancer
  • miR-34a


Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.


Keywords

  • CDK4
  • MDM2
  • TP53
  • nodular fasciitis
  • p16
  • senescence

TPH1[править]

[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways.


Keywords

  • Lactobacillus spp.
  • aging
  • brain

TPO[править]

Megakaryocytes promote osteoclastogenesis in aging.


Keywords

  • aging
  • bone marrow macrophage
  • megakaryocyte
  • osteoclast
  • thrombopoietin

TPP1[править]

FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.


Keywords

  • DNA damage response
  • FBXW7
  • TPP1
  • cellular senescence
  • chronic stress
  • idiopathic pulmonary fibrosis
  • premature aging
  • proteostasis
  • stem cells
  • telomere
  • telomere uncapping

TPR[править]

Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR.


Keywords

  • Cu loading
  • Cu/MCM-22
  • NH3-SCR
  • hydrothermal aging


Do traits of plant species predict the efficacy of species distribution models for finding new occurrences?


Keywords

  • dispersal
  • generalist
  • lifespan
  • niche models
  • range size
  • specialist


In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation.


Keywords

  • Aging resistance
  • Amorphization
  • Surface modification
  • Symmetrical structure

TRAF3[править]

TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.


Keywords

  • TRAF3
  • adipogenic differentiation
  • bone marrow-derived mesenchymal stem cells
  • miR-363-3p
  • osteogenic differentiation
  • senescence

TREM2[править]

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.


Keywords

  • TREM2
  • aging
  • dendritic spine density
  • learning and memory
  • long-term potentiation
  • synaptic plasticity


Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.


Keywords

  • NKG2D ligands
  • aging
  • inflammation
  • interferon type I response
  • microglia
  • neurodegeneration
  • senescence


Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice.


Keywords

  • Aging
  • Long-term potentiation
  • TREM2
  • astrocytes
  • learning and memory

TRIM21[править]

TRIM21 overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma.


Keywords

  • Glioma
  • TRIM21
  • cell senescence
  • drug resistance
  • p53-p21 pathway
  • prognosis

TRIM27[править]

TRIM27 Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination.


Keywords

  • EP300
  • TRIM27
  • breast cancer
  • cell apoptosis
  • cell senescence
  • chemoresistance
  • p21
  • prognosis
  • transcription
  • ubiquitination

TRIP13[править]

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome.


MeSH Terms

  • Aging
  • Alleles
  • Animals
  • Cell Cycle Proteins
  • Chromosome Disorders
  • Lung Neoplasms
  • Mice
  • Mice, Inbred C57BL
  • Mitosis
  • Mosaicism
  • Mutation
  • Phenotype
  • Progeria
  • Protein-Serine-Threonine Kinases

Keywords

  • Aging
  • Cancer
  • Cellular senescence
  • Genetic diseases
  • Oncology

TRPC6[править]

Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.


Keywords

  • SASP
  • Senescence
  • TRPC6
  • calcium
  • hydrogen peroxide
  • mTOR

TRPC7[править]

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B.


Keywords

  • TRPC7
  • aging
  • p53
  • tumor initiator gene
  • tumorigenesis
  • ultraviolet pathology

TRPV4[править]

TRPV4 receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications.


MeSH Terms

  • Animals
  • Calcium
  • Guinea Pigs
  • Humans
  • Muscle Contraction
  • Muscle, Smooth
  • TRPV Cation Channels
  • Urinary Bladder
  • Urothelium

Keywords

  • ATP release
  • TRPV4 receptor
  • aging
  • overactive bladders
  • urothelium


Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the TRPV4-K 2.3 signaling complex.


MeSH Terms

  • Animals
  • Biological Factors
  • Cardiovascular Diseases
  • Endothelial Cells
  • Endothelium, Vascular
  • Male
  • Potassium Channels, Calcium-Activated
  • Rats
  • Rats, Sprague-Dawley
  • TRPV Cation Channels
  • Vasodilation

Keywords

  • EDHF
  • KCa2.3
  • TRPV4
  • aging
  • endothelium
  • exercise

TSPO[править]

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge.


Keywords

  • 18 kDa translocator protein
  • aging
  • astrocytes
  • microglia
  • neuroinflammation
  • triggering receptor expressed on myeloid cells 2


Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.


MeSH Terms

  • Aging
  • Animals
  • Brain
  • Inflammation
  • Mice
  • Microglia
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Receptor, Cannabinoid, CB2
  • Receptors, GABA
  • Up-Regulation

Keywords

  • Cannabinoid receptor type 2
  • Immunostaining
  • Microglial activation
  • Positron emission tomography
  • Senescence-accelerated prone mouse
  • Translocator protein

TST[править]

H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and TST Expression.


Keywords

  • aging
  • donor
  • fructose
  • gastric mucosa
  • hydrogen sulfide
  • oxidative stress


Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.


Keywords

  • Aging
  • Concurrent training
  • Explosive force
  • Functional capacity
  • HIIT


Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging.


MeSH Terms

  • Adult
  • Aged
  • Aging
  • Body Mass Index
  • Cardiovascular Diseases
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Self Report
  • Sleep
  • Telomere
  • Waist Circumference
  • Wearable Electronic Devices
  • Young Adult

Keywords

  • Data integration
  • Predictive markers
  • Risk factors
  • Senescence


Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing.


MeSH Terms

  • Accelerometry
  • Aged
  • Aging
  • Cross-Sectional Studies
  • Exercise
  • Female
  • Health Status
  • Humans
  • Independent Living
  • Ireland
  • Longitudinal Studies
  • Male
  • Polysomnography
  • Self Report
  • Sleep
  • Time Factors

Keywords

  • GENEActiv
  • accelerometer
  • actigraphy
  • older population
  • sleep duration

TTL[править]

Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Biomarkers
  • Body Mass Index
  • Cohort Studies
  • Female
  • Germany
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Oxidative Stress
  • Waist Circumference
  • Waist-Hip Ratio

Keywords

  • Body mass index
  • Free radicals
  • Oxidative stress
  • Reactive oxygen metabolites
  • Total thiol levels
  • Waist circumference
  • Waist-to-hip ratio

TTN[править]

LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.


MeSH Terms

  • Aging
  • Apoptosis
  • Brain Neoplasms
  • Cell Line, Tumor
  • Cell Proliferation
  • Chromosomal Proteins, Non-Histone
  • Computational Biology
  • Drug Resistance
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs
  • Osteosarcoma
  • RNA, Long Noncoding

Keywords

  • aging and age-related diseases
  • lncRNA TTN-AS1
  • malignant brain tumour domain containing protein 1
  • miR-134-5p
  • osteosarcoma
  • resistance

TTR[править]

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.


MeSH Terms

  • Amyloid Neuropathies, Familial
  • Animals
  • Cell Death
  • Cell Line, Tumor
  • Disease Models, Animal
  • Drosophila
  • HEK293 Cells
  • Humans
  • Locomotion
  • Longevity
  • Mutant Proteins
  • Mutation
  • Nerve Degeneration
  • Prealbumin

Keywords

  • Amyloidosis
  • Drosophila melanogaster
  • ERQC
  • Endoplasmic reticulum quality control
  • Proteostasis
  • TTR
  • Transthyretin

TXNIP[править]

Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats.


Keywords

  • Aging
  • Microglia
  • NLRP3 inflammasome
  • Saponins from Panax notoginseng.
  • TXNIP
  • neuroinflammation


Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP).


Keywords

  • Aging
  • Beta-cells
  • Cell cycle
  • Metabolic stress
  • Redox homeostasis
  • Thioredoxin-interacting protein


[Effect of diabetic induced thioredoxin interacting protein (TXNIP) on islet cell senescence].


MeSH Terms

  • Animals
  • Carrier Proteins
  • Cellular Senescence
  • Diabetes Mellitus, Experimental
  • Islets of Langerhans
  • Mice
  • Thioredoxins

Keywords

  • INS-1 cell
  • cell senescence
  • diabetes
  • thioredoxin interacting protein


PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis.


Keywords

  • PRMT5
  • TRIM21
  • TXNIP
  • p21
  • senescence

TXNRD2[править]

Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression.


Keywords

  • Breast cancer
  • Immune surveillance
  • ROS
  • Senescence
  • TXNRD2
  • Wogonin

U2AF1[править]

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.


Keywords

  • Aging
  • DEPs
  • HSPC
  • iTRAQ
  • mRNA splicing

UACA[править]

Knockdown of [i]UACA[/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells.


Keywords

  • HIF1α
  • UACA
  • hepatocellular carcinoma
  • invasion
  • knockdown
  • proliferation
  • senescence

UCHL1[править]

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.


Keywords

  • Aging
  • Axonal injury
  • Neurodegeneration
  • Traumatic brain injury
  • Ubiquitin carboxy terminal hydrolase L1
  • Ubiquitin proteasome pathway

UCP1[править]

Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.


Keywords

  • adipose tissue
  • aging
  • growth hormone
  • inflammation
  • uncoupling protein 1 (UCP1)


Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.


Keywords

  • Apoe knockout mice
  • Beige fat
  • Gene expression
  • Hyperlipidemia
  • Longevity
  • Uncoupling protein 1


Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice.


MeSH Terms

  • Adipocytes, Beige
  • Adipocytes, White
  • Adipose Tissue
  • Aging
  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Leptin
  • Male
  • Mice
  • Mice, Obese
  • Sympathetic Nervous System
  • Tyrosine 3-Monooxygenase
  • Uncoupling Protein 1

Keywords

  • beige adipocytes
  • leptin
  • sympathetic nerve system


Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.


MeSH Terms

  • Adipose Tissue, Brown
  • Aging
  • Animals
  • Brain
  • Female
  • Male
  • Mice, Inbred C57BL
  • Mitochondrial Proteins
  • Muscle, Skeletal
  • Sex Characteristics
  • Spleen


An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.


MeSH Terms

  • Adipocytes
  • Aging
  • Animals
  • Humans
  • Inflammation
  • Intra-Abdominal Fat
  • Macrophages
  • Mice
  • Obesity
  • Phenotype
  • Physical Conditioning, Animal
  • Resistance Training

UGT2B28[править]

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation.


MeSH Terms

  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Carcinoma, Hepatocellular
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Glucuronosyltransferase
  • Humans
  • Life Expectancy
  • Liver Neoplasms
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Survival Analysis
  • Young Adult

Keywords

  • Alcoholism
  • Xenobiotic metabolizing enzymes
  • Young hepatocellular carcinoma; age of death

USP7[править]

Deubiquitinase USP7 regulates [i]Drosophila[/i] aging through ubiquitination and autophagy.


Keywords

  • DMC
  • Drosophila
  • USP7
  • aging
  • autophagy

VCAM1[править]

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence.


Keywords

  • Cell senescence
  • Metastasis
  • Metastatic breast cancer (MBC)
  • Receptor tyrosine kinase (RTK)
  • Sunitinib

VDAC1[править]

Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity.


Keywords

  • Complex I
  • Droplet digital PCR
  • Longevity
  • Mammals
  • Mitochondria
  • NDUFS4 subunit
  • NDUFV2 subunit
  • VDAC
  • Western blot


Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa.


Keywords

  • Aging
  • Colonic crypt
  • Expression
  • Intestine
  • Mitochondria
  • OXPHOS

VDR[править]

25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice.


Keywords

  • 25-Hydroxyvitamin D(3)
  • Diabetic periodontitis
  • Inflammaging
  • SOCS3
  • Senescence
  • Senescence-associated secretory phenotypes


1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.


MeSH Terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
  • Aging
  • Animals
  • Bone and Bones
  • Cells, Cultured
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinase Inhibitor p19
  • DNA Damage
  • Enhancer of Zeste Homolog 2 Protein
  • Female
  • Histones
  • Male
  • Mesenchymal Stem Cells
  • Mice
  • Mice, Knockout
  • Osteocytes
  • Osteogenesis
  • Osteoporosis
  • Oxidative Stress
  • Receptors, Calcitriol
  • Vitamin D

Keywords

  • Ezh2
  • Vitamin D
  • cellular senescence
  • osteogenesis
  • osteoporosis
  • p16


Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model.


Keywords

  • Active vitamin D
  • Cell senescence
  • Non-alcoholic fatty liver disease
  • Oxidative stress
  • P53-p21 signaling pathway
  • Vitamin D receptor

VEGFA[править]

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.


MeSH Terms

  • Aged
  • Aged, 80 and over
  • Aging
  • Apolipoprotein E4
  • Cognitive Aging
  • Cognitive Dysfunction
  • Female
  • Gene Expression
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Neovascularization, Physiologic
  • Neuropilin-1
  • Vascular Endothelial Growth Factor A

Keywords

  • APOE-ε4
  • Aging
  • Cognition
  • Gene expression
  • Vascular endothelial growth factor (VEGF)

VGLL4[править]

The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells.


Keywords

  • LncRNA MEG3
  • breast cancer
  • cell senescence
  • etoposide
  • lung adenocarcinoma

VHL[править]

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.


Keywords

  • Aging
  • C. elegans
  • EGL-9/PHD
  • HIF-1 signaling
  • Hypoxic response
  • Lifespan
  • RHY-1

VIM[править]

Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi).


MeSH Terms

  • Aging
  • Animals
  • Cell Culture Techniques
  • Cell Line
  • Cell Proliferation
  • Cell Shape
  • Chromosomes, Mammalian
  • Fibroblasts
  • Male
  • Muntjacs
  • Postmortem Changes
  • Skin

Keywords

  • Characteristics
  • Chinese muntjac
  • Fibroblast cell line
  • Postmortem skin

VIP[править]

Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging.


Keywords

  • VIP
  • action potential
  • aging
  • calretinin
  • circuit disinhibition
  • hippocampus
  • synapse


Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials.


Keywords

  • Aging
  • Cognitive impairment
  • Exercise
  • Meta-analysis
  • Nutrition

VSIG4[править]

Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.


Keywords

  • VSIG4
  • adipose tissue
  • aging
  • frailty index
  • immune checkpoint
  • inflammation
  • macrophage
  • mouse

WASL[править]

Loss of Wasl improves pancreatic cancer outcome.


Keywords

  • Cancer
  • Cellular senescence
  • Mouse models
  • Oncology

WDR5[править]

Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 .


MeSH Terms

  • Acute Kidney Injury
  • Animals
  • Biphenyl Compounds
  • Cell Line
  • Cyclin-Dependent Kinase Inhibitor p16
  • Dihydropyridines
  • Drug Evaluation, Preclinical
  • Fibroblasts
  • Histone-Lysine N-Methyltransferase
  • Histones
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Mice, Inbred C57BL
  • Myeloid-Lymphoid Leukemia Protein
  • Rats
  • Renal Insufficiency
  • Reperfusion Injury

Keywords

  • H3K4me3
  • MLL1
  • WDR5
  • acute kidney injury
  • p16(INK4a)
  • senescence

WFDC2[править]

Differences in biomarkers and molecular pathways according to age for patients with HFrEF.


Keywords

  • aging
  • biological age
  • biomarkers
  • chronological age
  • heart failure with reduced ejection fraction

WIPI2[править]

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2.


MeSH Terms

  • Aging
  • Animals
  • Autophagy
  • Autophagy-Related Proteins
  • Mice, Transgenic
  • Models, Biological
  • Neurons
  • Phagosomes
  • Phosphate-Binding Proteins
  • RNA, Messenger

Keywords

  • Aging
  • WIPI2
  • autophagosome biogenesis
  • autophagy
  • macroautophagy
  • neurodegeneration
  • neuronal autophagy

WNT1[править]

Plasma proteomic profile of age, health span, and all-cause mortality in older adults.


Keywords

  • SomaScan® assay
  • aging
  • proteomics
  • weighted gene co-expression network analysis

WNT10A[править]

Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development.


Keywords

  • Wnt signaling pathway
  • cell senescence
  • differentiation
  • osteoarthritis
  • synovial mesenchymal stem cells (SMSCs)

WNT3A[править]

Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells.


Keywords

  • ATII cells
  • Aging
  • Cellular senescence
  • IPF
  • WNT signaling

WNT7A[править]

Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.


Keywords

  • WNT signaling
  • WNT7A
  • cell cycle
  • chemotherapeutic agents
  • leukemias
  • senescence

WRN[править]

The Impact of Vitamin C on Different System Models of Werner Syndrome.


Keywords

  • Werner syndrome
  • aging
  • mouse
  • stem cells
  • vitamin C
  • worm


WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells.


Keywords

  • Cancer
  • NXF1 export receptor
  • Senescence
  • Translation
  • Werner syndrome protein
  • mRNA export


MIB1-mediated degradation of WRN promotes cellular senescence in response to camptothecin treatment.


Keywords

  • CPT
  • Mind bomb 1
  • Werner syndrome protein
  • aging
  • protein stability


A Case Report of Werner's Syndrome With a Novel Mutation From India.


Keywords

  • aging
  • novel mutation
  • progeria
  • werner syndrome
  • wrn gene


Evidence for premature aging in a Drosophila model of Werner syndrome.


MeSH Terms

  • Aging, Premature
  • Animals
  • Behavior, Animal
  • Body Composition
  • Body Weight
  • DNA Repair
  • Drosophila
  • Drosophila Proteins
  • Exonucleases
  • Female
  • Gastrointestinal Neoplasms
  • Male
  • Motor Activity
  • Muscle Weakness
  • Mutation
  • Phenotype
  • Werner Syndrome

Keywords

  • Aging
  • DNA repair
  • Locomotor function
  • Tumor
  • Werner syndrome

WT1[править]

Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts.


Keywords

  • Backfat
  • Gilts
  • Leptin
  • Litter performance
  • Longevity
  • Mating

WWP1[править]

The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart.


MeSH Terms

  • Age Factors
  • Animals
  • Cells, Cultured
  • Diastole
  • Disease Models, Animal
  • Extracellular Matrix
  • Female
  • Fibroblasts
  • Heart Failure
  • Hypertrophy, Left Ventricular
  • Male
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Myocardium
  • Phenotype
  • Proteolysis
  • Stroke Volume
  • Ubiquitin-Protein Ligases
  • Ventricular Dysfunction, Left
  • Ventricular Function, Left
  • Ventricular Remodeling

Keywords

  • aging
  • cardiac hypertrophy
  • diastolic dysfunction
  • heart failure
  • ventricular remodeling

XBP1[править]

Age-dependent impairment of adipose-derived stem cells isolated from horses.


Keywords

  • Aging
  • Endoplasmic reticulum stress
  • Equine adipose-derived mesenchymal stem cells
  • Insulin resistance
  • Pro-inflammatory cytokines

XDH[править]

Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield.


Keywords

  • Allantoin
  • Reactive oxygen species
  • Rice (Oryza sativa L.)
  • Senescence
  • Xanthine dehydrogenase
  • Yield

ZC3H12A[править]

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation.


MeSH Terms

  • Aging
  • Animals
  • Calgranulin A
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cornified Envelope Proline-Rich Proteins
  • Epidermis
  • Gene Expression Regulation
  • Gene Ontology
  • Inflammation
  • Interleukin-1
  • Keratinocytes
  • Keratins
  • Lymph Nodes
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Proliferating Cell Nuclear Antigen
  • Ribonucleases
  • Skin
  • Spleen
  • Transcriptome

Keywords

  • MCPIP1
  • Regnase-1
  • Skin inflammation
  • ZC3H12A

ZEB2[править]

miR-200b regulates cellular senescence and inflammatory responses by targeting ZEB2 in pulmonary emphysema.


MeSH Terms

  • Animals
  • Cell Line
  • Cellular Senescence
  • Disease Models, Animal
  • Gene Expression
  • Gene Expression Regulation
  • Inflammation
  • Lung
  • Mice
  • MicroRNAs
  • Pulmonary Emphysema
  • Zinc Finger E-box Binding Homeobox 2

Keywords

  • ZEB2
  • cellular senescence
  • inflammation
  • miR-200b
  • pulmonary emphysema

ZMPSTE24[править]

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells.


MeSH Terms

  • Bone Marrow Cells
  • Cell Cycle
  • Cell Proliferation
  • Cell Survival
  • Cells, Cultured
  • Cellular Senescence
  • Coculture Techniques
  • Collagen Type II
  • Female
  • Humans
  • Intervertebral Disc Degeneration
  • Male
  • Matrix Metalloproteinase 9
  • Membrane Proteins
  • Mesenchymal Stem Cells
  • Metalloendopeptidases
  • Middle Aged
  • Nucleus Pulposus
  • Signal Transduction
  • Transcription Factor RelA
  • Up-Regulation
  • beta-Galactosidase

Keywords

  • 3D co-culture
  • ZMPSTE24
  • bone marrow-derived mesenchymal stem cells
  • nucleus pulposus
  • senescence
Источник — https://transhumanist.ru/index.php?title=Публикации_о_генах_и_старении_(titles)&oldid=2650