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...sibility of broadening human potential by overcoming [[Senescence|aging]], cognitive shortcomings, [[abolitionism|involuntary suffering]], and our [[space explo ...]; [[cryonics]] procedures; and many other possible human modification and enhancement technologies. ...

...ciated with a loss of motor functions and a general progressive decline in cognitive functions. Physical exercise is one of the ways in which inflammatory level ...APα, [[[[CDKN2A]]]] p14 , and TAU3 transcript expression and contribute to cognitive decline. ...

|title=I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. * Cognitive Dysfunction ...

...pted. Cancer, malaria, dementia, aging, starvation, unnecessary suffering, cognitive shortcomings are all among the presents that we wisely refuse. Our own spec ...were miserly in the extent to which you gave us awareness of our somatic, cognitive, and emotional processes. You held out on us by giving the sharpest senses ...

...Older adults exhibit the oblique effect and it is associated with specific cognitive processes and regional brain networks that may facilitate future investigat ...es increases with age; 2) the age-related prolongation of APD is due to an enhancement of basal late Na current (I ); 3) inhibition of I may protect aging heart ...

...of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women. ...domains and suggests that further examination of the role of this gene in cognitive function is warranted. ...

...arts and plasmid transfection/RNA interference of H9C2 cells revealed that enhancement of [[HSF1]] expression promotes Omi/HtrA2 expression by inducing the promot ...Future studies shall include testing potential benefits of pharmacological enhancement of the deacetylation activity of SIRT1 after the onset of the symptom. ...

|title=Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. |title=Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism. ...

...he permeability of the BBB was successfully increased in all animals (mean enhancement: 19±11% relative to untreated hemisphere). There was a single adverse even ...

|title=The Relationship between Cardiorespiratory Fitness and Montreal Cognitive Assessment Scores in Older Adults. ...n those with a moderate to high level of CRF, and thereby help to maintain cognitive function in healthy older adults. ...

...-dependent manner. The mechanism of this effect may be associated with the enhancement of the intracellular anti-oxidant capacity. These findings provide a theore ...expression was the same as that for the proteins, which confirmed that the enhancement occurred at the gene level. As such, [[EPO]] can significantly resist or de ...

|title=The behavioral deficits and cognitive impairment are correlated with decreased IGF-II and ERK in depressed mice i |title=The neural mechanisms underlying the aging-related enhancement of positive affects: electrophysiological evidences. ...

'''Transhumanism''' is the belief or movement in favour of human enhancement, especially beyond current human limitations and with advanced technology s ...nvision the possibility of broadening human potential by overcoming aging, cognitive shortcomings, involuntary suffering, and our confinement to planet Earth. ...

...vered. Given the age-related decline of the dopamine (DA) system in normal cognitive aging, DA neuromodulation is one plausible mechanism. Hence, agents that bo ...cts of amphetamine. However, they were more vulnerable to exposure-induced cognitive impairments. For example, adolescent-exposed rats displayed delay-dependent ...

|title=Staging of amyloid β, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses. |title=The prevalence and progression of mild cognitive impairment among clinic and community populations: a systematic review and ...

...to be an important component of functional failure underlying age-related cognitive decline. Practical and sensitive measurement is necessary, therefore, to su ...tor within CBF aides in greater sensitization of task fMRI signals. From a cognitive standpoint, compared to young adults, the older participants showed a delay ...

...aging and represent a potential strategy for the prevention of age-related cognitive decline. * Cognitive decline ...

...R-34a-overexpressing cells. Analysis of miR-34a-induced secretome revealed enhancement of several pro-inflammatory cytokines and chemokines, including [[IL6]], pr |title=Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. ...

...lifestyle, autonomy, comorbidities, risk of pressure sore, nutritional and cognitive status) was used to calculate the [[MPI]] score and to categorize patients ...[[MPI]]-SVaMA, a validated prognostic tool based on age, sex, comorbidity, cognitive status, mobility and functional disability, pressure sore risk, and social ...

|title=Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and [[NLRP3]] infla |title=Cognitive impairment in elderly patients with rheumatic disease and the effect of dis ...