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Corticotropin-releasing factor-binding protein precursor (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP) [CRFBP]


Aging-related changes in cutaneous corticotropin-releasing hormone system reflect a defective neuroendocrine-stress response in aging.

Skin, being a mirror of the body, is a major target for aging research. Aging is a complex process that involves the decline of function or dysfunction of many systems. The corticotropin-releasing hormone (CRH) system is involved in skin inflammation. In addition, CRH has a suggested role in age-associated conditions and in animal aging models. However, a consistent logic interaction between the different CRH system components and the aging process has, to our knowledge, never been examined before. The expression of CRH, CRH-binding protein ([[CRHBP]]), CRH receptor 1 (CRHR1), and CRH receptor 2 ([[CRHR2]]) in healthy skin samples of 42 patients of different ages (18-92 years) was evaluated by immunohistochemistry, and the age-related changes were assessed. Compared with young skin, the aged skin displayed an upregulation of CRH in sebaceous glands and CRHR1 in hair follicles and the epidermis. Moreover, age-associated downregulation of [[CRHBP]] in the sebaceous and sweat glands was detected, whereas the [[CRHR2]] showed no age-related changes. Our findings suggest that the age-associated changes in the expression of CRH system components reflect an exaggerated stress response reaction, putting the aged skin continuously in a stress-like situation.

MeSH Terms

  • Adult
  • Aged
  • Aging
  • Carrier Proteins
  • Corticotropin-Releasing Hormone
  • Female
  • Humans
  • Male
  • Middle Aged
  • Receptors, Corticotropin-Releasing Hormone
  • Sebaceous Glands
  • Skin
  • Stress, Physiological
  • Young Adult